Technical Information Vitamin A Palmitate

September 2007
Supersedes issue dated August 2006 Vitamin A Acetate
MEMC 050203e-05/Page 1 of 6

® = Registered trademark Active ingredient for the cosmetics industry.

of BASF Aktiengesellschaft
MEMC 050203e-05 September 2007 Page  of 6 Vitamin A Palmitate, Vitamin A Acetate

Structural formula

Product range Retinyl Palmitate 1.7 Mio IU/g 10013349

Retinyl Palmitate 1.7 Mio IU/g stab. with Tocopherol 10065085
Retinyl Palmitate 1.7 Mio IU/g stab. with BHT 10068345
Retinyl Palmitate 1.0 Mio IU/g stab. with BHT 10078915
Retinyl Palmitate 1.0 Mio IU/g stab with Tocopherol 10015772
Retinyl Acetate 1.5 Mio IU/g stab. with BHT 10013120

Retinyl Palmitate 1.0 Mio IU/g and Retinyl

Acetate 1.5 Mio IU/g are diluted in Sunflower Seed Oil

Synonyms Retinyl palmitate, all-trans-retinol palmitic acid ester

Retinyl acetate, all-trans-retinol acetate

INCI name Retinyl Palmitate 1.7 Mio IU/g: Retinyl Palmitate

Retinyl Palmitate 1.0 Mio IU/g: Retinyl Palmitate (and) Helianthus Annuus
(Sunflower) Seed Oil
Retinyl Acetate 1.5 Mio IU/g: Retinyl Acetate (and) Helianthus Annuus
(Sunflower) Seed Oil

Molecular formula Retinyl Palmitate: C36H60O2

Retinyl Acetate: C22H32O2

Molar Mass Retinyl Palmitate 524.9 g/mol

Retinyl Acetate 328.5 g/mol

CAS-No. 79-81-2 (Retinyl Palmitate)

127-47-9 (Retinyl Acetate)
8001-21-6 (Sunflower seed oil)

PRD-No. Reninyl Palmitate 1.7 Mio 30041032

Retinyl Palmitate 1.7 Mio stab. With Tocopherol 30041031
Retinyl Palmitate 1.7 Mio stab. With BHT 30041041
Retinyl Palmitate 1.0 Mio stab. With Tocoopherol 30041043
Retinyl Palmitate 1.0 Mio stab. With BHT 30041040
Retinyl Acetate 1.5 Mio stab. With BHT 30041021

Description At room temperature, the product is a viscous, yellow oil that may contain some
crystals. Mild odor. The assay of Vitamin A Palmitate 1.0 Mio IU/g and Vitamin
A Acetate 1.5 Mio IU/g is adjusted by adding pharmaceutical-grade sunflower
seed oil.

Solubility Miscible with hydrocarbons, ethers, fats and oils. The solvent should contain
no peroxides. Insoluble in water. It is necessary to use a solubilizer in aqueous-
alcoholic preparations.
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Specification See separate document: “Standard Specification (not for regulatory purposes)“
available via BASF’s WorldAccount:
https://worldaccount.basf.com (registered access).

Monographs The product complies with the current Ph. Eur., USP and FCC monographs.

Applications Vitamin A Esters are active ingredients for cosmetic skin-care products. They
release Vitamin A on contact with enzymes in the skin. Vitamin A stimulates
cell growth, increases enzyme activity and normalizes cell division. They are
therefore able to counteract the skin-aging process and improve the appearance
of UV-damaged skin.

1 International unit (IU) can be converted into weight with the following equations
1 IU = 0.3 µg Vitamin A alcohol (Retinol)
0.344 µg Vitamin A Acetate
0.55 µg Vitamin A Palmitate

Stability and storage Vitamin A Palmitate 1.7 Mio IU/G is available stabilized and unstabilized. All
grades are available stabilized with approx. 10 mg of DL-alpha-Tocopherol
per Mio IU or with approx. 10 mg of BHT per Mio IU.
Vitamin A Esters are sensitive to air, light, moisture and heat.
The product has a shelf life of 12 months if stored in the original sealed
containers at max. 25°C, and 24 months at 5°C.
Opened original containers should be flushed with an inert gas and used
up quickly.
Prior to use, the product must be heated to 40°C in the unopened container and
homogenized.

Occasionally difficult to dissolve crystals can be found in the product. In such

cases placing the canister in a water bath at 60°C and letting it gently warm up,
with homogenisation, will enable complete dissolution of the crystals.

Typical formulations Antiaging cream No. 62/00035

% Ingredients Supplier INCI name
A 2.00 Cremophor A 25 ®
(1) Ceteareth-25
2.00 Cremophor A 6 ®
(1) Ceteareth-6, Stearyl Alcohol
5.00 Lanette O (27) Cetearyl Alcohol
5.00 Sunflower Seed Oil Sunflower (Helianthus Anuus)
Seed Oil
10.00 Luvitol® EHO (1) Cetearyl Ethylhexanoate
10.00 Paraffin Oil Mineral Oil
B 0.05 Edeta® BD (1) Disodium EDTA
3.00 1,2-Propylene Glycol (1) Propylene Glycol
Care
2.00 D-Panthenol 50 P (1) Panthenol, Propylene Glycol
q.s. Preservative
60.35 Water dem. Aqua
C 0.50 Vitamin A Palmitate (1) Retinyl Palmitate
1.7 Mio. I.E./g
0.10 DL-alpha-Tocopherol (1) Tocopherol
q.s. Perfume

Production: Heat phases A and B separately to about 80°C.

Stir phase B into phase A and homogenize.
Cool to about 40°C, add phase C and homogenize
again.
Properties: Viscosity: 5000 mPa·s Haake Viscotester VT-02
pH value: 7.0
MEMC 050203e-05 September 2007 Page  of 6 Vitamin A Palmitate, Vitamin A Acetate

Vitamin lotion No. 62/00042

% Ingredients Supplier INCI name
A 6.00 Cremophor WO 7 ®
(1) PEG-7 Hydrogenated Castor Oil
2.00 TeCero Wax 1030 K (73) Microcrystalline Wax
0.20 Bisabolol nat. (1) Bisabolol
1.00 Bees Wax 3044 PH (73) Bees Wax
0.50 Cetiol SB 45 (27) Butyrospermum Parkii (Shea
Butter)
1.00 Jojoba Oil Jojoba (Buxus Chinensis) Oil
7.00 Luvitol® EHO (1) Cetearyl Octanoate
7.00 Paraffin Oil Mineral Oil
0.10 Ascorbyl Palmitate Ascorbyl Palmitate
B 5.00 1,2-Propylene Glycol (1) Propylene Glycol
Care
0.10 Edeta® BD (1) Disodium EDTA
q.s. Preservative
0.70 Magnesium Sulfate- (20) Magnesium Sulfate
7-hydrate
63.20 Water dem. Aqua
C 1.00 Vitamin E Acetate (1) Tocopheryl Acetate
0.50 DL-alpha-Tocopherol (1) Tocopherol
0.20 Vitamin A Palmitate (1) Retinyl Palmitate
1.0 Mio. I.E./g
1.00 Vitamin F Glyceryl (58) Glyceryl Linoleate, Glyceryl Lino-
Ester lenate, Glyceryl Arachidonate
q.s. Perfume
D 2.50 Kollatherm (23) Soluble Collagen, Glycerol
1.00 Alpha-Elastin (23) Hydrolyzed Elastin

Production: Heat phases A and B separately to about 85°C.

Stir phase B into phase A and homogenize.
Cool to about 40°C, add phases C and D and
homogenize again.
Properties: Viscosity: 6000 mPa·s Haake Viscotester VT-02
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Suppliers 1. BASF Aktiengesellschaft

67056 Ludwigshafen, Germany
Tel.: (0621) 60-0
Fax: (0621) 60-42525

20. Merck KGaA

Frankfurter Straße 250,
64293 Darmstadt, Germany
Tel.: (06151) 727869
Fax: (06151) 728333

23. GFN Herstellung von Naturextrakten GmbH,

Straßburg 16, D-69483 Wald-Michelbach, Germany
Tel.: (06207) 7007
Fax: (06207) 1276

27. Cognis Deutschland GmbH -

Care Chemicals
Henkelstr. 67
40191 Düsseldorf, Germany
Tel.: (0211) 7940-2289
Fax: (0211) 798-2016

58. Chemisches Laboratorium Dr. Kurt Richter GmbH (CLR)

Bennigsenstraße 25, 12159 Berlin, Germany
Tel.: 030/852-7075
Fax: 030/851-1822

73. Tromm GmbH, Wachs- und Ceresin-Fabriken

Feuerstraße 7 - 17
50735 Köln (Weidenpesch)
Tel. 49 221 974552-0
Fax: 49 221 974552-30

Note „While the descriptions, designs, data and information contained herein are
presented in good faith and believed to be accurate, it is provided for your
guidance only. Because many factors may affect processing or application/use,
we recommend that you make tests to determine the suitability of a product
for your particular purpose prior to use.
NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING
WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS,
OR THAT DATA OR INFORMATION MAY BE USED WITHOUT INFRINGING
THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL
THE DESCRIPTIONS, INFORMATION, DATA OR DESIGNS PROVIDED BE
CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE.
Further, you expressly understand and agree that the descriptions, design, data
and information furnished by BASF hereunder are given gratis and BASF assumes
no obligation or liability for the description, designs, data and information
given or results obtained, all such being given and accepted at your risk.“

September 2006
MEMC 050203e-05 September 2007 Page  of 6 Vitamin A Palmitate, Vitamin A Acetate

BASF Corporation
Fine Chemicals Division - Cosmetic Solutions - 07932 Florham Park - USA, Region N.J.- www.cosmetics.basf.com