The chemistry and biological study of heterocyclic compounds has been an

interesting field for a long time in medicinal chemistry. A number of heterocyclic

derivatives containing nitrogen and sulphur atom serve as a unique and versatile
scaffolds for experimental drug design 1.

Benzothiazole is one of the most important heterocycle that has received

overwhelming response owing to its diversified molecular design and remarkable
optical, liquid and electronic properties 2.
In 1950s, a number of 2-aminobenzothiazoles were intensively studied as central
muscle relaxants. Since then, biologist’s attention was drawn to this series when
pharmacological profile of Riluzole (6-trifluoormethoxy-2-benzothiazolamines,
Rilutek), as a Glutamate neurotransmission inhibitor was discovered 3-7.

Heterocyclic chemistry is one of the foremost advanced and fascinating branches

of chemistry. Over the past four decades heterocyclic compounds were reported to
have wide-range of biological applications and are still of great scientific interest
till today. Heterocyclic structural units are broadly disseminated in nature and
played a vital role as nucleic acids, plant alkaloids, anthocyanins, vitamins,
proteins, hormones, flavones, haemoglobin, chlorophyll etc. Heterocyclic
compounds were frequently observed as a key auxiliary unit in artificial . and
agrochemicals. Most of the drugs such as antimicrobial, antitumor, antiviral,
anticancer, antibiotic, antiinflammatory, antidepressant, anthelmintic,
antituberculosis, anti-HIV, antidiabetic, antimalarial, anticonvulsant etc; are
heteorcyclic compounds. The drug atorvastatin1 which is blood cholesterol reducer
used for the treatment of dyslipidemia and also for the prevention of cardiovascular
illnesses also belongs to heterocyclic family and is one of the important industrial
products till now. Apart from in drugs, heterocyclics as a key structural unit play
prominent role as herbicidal, insecticidal and fungicidal agents. 1

Problem of multi-drug resistant microorganisms has reached an alarming

level around the world and the synthesis of new efficient anti-infective compounds
has become an urgent need for the treatment of microbial infections.1
Benzothiazole is a heterocyclic compound, weak base, having varied biological
activities and still of great scientific interest now a days. They are widely found in
bioorganic and medicinal chemistry with application in drug discovery.
Benzothiazole moites are part of compounds showing numerous biological
activities such as antimicrobial [1-5] anticancer [6-8], anthelmintic [9], and anti-
diabetic [10] activities

Triazoles constitute an important class of pharmaceutically and

medicinally compounds which are widely used as antioxidant [1],
anti-inflammatory [2], antimicrobial [3] and anticancer [4]. They
are also used for the preparation of carbonyl compounds, in enzymatic
reaction as intermediates and as protecting groups [5]. Many
triazole based Schiff bases have also been reported to possess more
increased bioactivities due to azomethine linkage [6,7].
]. In the current study, we selected 4,4’-diaminodiphenylmethane as heterocyclic
framework due to its various biological response profile and diversity in the
reactions.10-15 Such as, metal chelating properties of these heterocycles that
coordinates with different metal ion and antioxidant ability of these derivatives.16-
17 The purpose of this study is to report the synthesis, and anti-
acetylcholinesterase inhibition, of synthesized compounds by complexation with
different metals which can enhance hydrophobic nature in the compound.18.