HASHIMOTO’S THYROIDITIS

AUTOANTIBODIES ATTACK

Breakdown in SELF-TOLERANCE
Triggers: & induction of AUTOIMMUNITY
Infection
Environment
Diet
Genetic/Family History
Generation of a large number of:
ü auto-reactive T-helper (Th) cells
ü auto-antibody-producing B cells
ü cytotoxic T (Tc) lymphocytes
tissue
Increase TSH but low compensation;
T3T4 due to tissue decrease TSH
destruction and due to enough
inflammation; T4;
symptoms worsen hypothyroid
symptoms
lessen

T-cell mediated cytotoxicity Thyrocyte injury Ab-dependent cell-mediated cytotoxicity

goiter

ü Cell death of thyrocytes

weight
ü Destruction of parenchyma: Fibrosis
fatigue gain
& muscle ü Lymphocytic infiltration
aches

Lypho
dry skin
brittle nails
HYPOTHYROIDISM:
­ TSH
cold LOW metabolic rate
¯ T3, T4
intolerance Clinical Diagnosis
+ Anti-thyroid peroxidase
manifestations
+ Anti-thyroglobulin

depression Levothyroxine
(Synthetic thyroxine)
poor memory
headaches
Treatment

© Bienn Paulo A. Laforteza || MMSU MD 2021 || Family Medicine