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Motivation and Changes in Depression

Article  in  Cognitive Therapy and Research · April 2012


DOI: 10.1007/s10608-012-9458-3

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Cogn Ther Res
DOI 10.1007/s10608-012-9458-3

ORIGINAL ARTICLE

Motivation and Changes in Depression


David Burns • Henny Westra • Mickey Trockel •

Aaron Fisher

Ó Springer Science+Business Media, LLC 2012

Abstract This study evaluated the capacity of the Will- Keywords Motivation  Willingness  Depression 
ingness Scale (WS) to predict changes in depression over Inpatients  Structural equation modeling
the course of a brief inpatient admission. Two cohorts
(N = 160) of adult inpatients completed the Willingness
Scale along with a measure of depression following Introduction
admission. Depression severity was assessed approxi-
mately 4 days later, prior to discharge. Data were evaluated Despite high levels of disability associated with mental
using structural equation modeling. Higher WS scores health problems such as depression (Judd et al. 2000), non-
predicted greater reductions in depression in both cohorts, adherence with recommended treatment procedures is a
and the magnitude of this effect was large. The fits of the formidable problem in multiple settings and populations. For
models were outstanding, with no significant differences in example, in their analysis of over 740,000 new prescriptions
any parameter estimates across the two cohorts. The WS for Selective Serotonin Reuptake Inhibitors (SSRIs), Eaddy
predicts changes in depression, even within a brief inpa- and Regan (as cited in Keene 2005) reported that nearly 50 %
tient admission where the treatment is predominantly bio- of patients failed to adhere for a minimum of 60 days and a
logical. These results replicate results of previous studies in mere 28 % were compliant at 6 months. In fact, poor
outpatient populations where CBT was the primary treat- adherence with treatment regimens is the primary cause for
ment and suggest motivational factors may play an readmission and relapse in a number of psychological dis-
important role in causation and recovery from depression. orders, including bipolar mood disorder (Svarstad et al.
2001) and schizophrenia (Weiden et al. 2004).
Psychotherapy homework (HW) assignments are fre-
quently recommended across various types of psychotherapy
(Kazantzis and Ronan 2006) and are widely hypothesized
D. Burns  M. Trockel (&)
to be essential to the efficacy of empirically supported
Department of Psychiatry and Behavior Sciences, Stanford
University, 401 Quarry Road, Stanford, CA 94305, USA treatments such as Cognitive Behavioral Therapy (CBT;
e-mail: trockel@stanford.edu Kazantzis et al. 2005). Nonetheless, HW non-adherence is a
D. Burns commonly acknowledged problem limiting the efficacy of
e-mail: david@feelinggood.com treatment (for a review see Kazantzis et al. 2000). For
example, Helbig and Fehm (2004) surveyed practicing CBT
H. Westra
therapists regarding their clients’ HW adherence. Therapists
Department of Psychology, York University, Toronto,
ON, Canada reported that 74.5 % of clients expressed doubts about their
e-mail: hwestra@yorku.ca ability to complete HW tasks and only 38.9 % of clients were
identified as totally compliant. Resistance in therapy is
A. Fisher
consistently associated with poorer outcomes (for a review
Department of Psychology, The Pennsylvania State University,
University Park, PA, USA see Beutler et al. 2001), whereas HW adherence in CBT
e-mail: aaron@psu.edu is associated with more positive outcomes (Burns and

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Cogn Ther Res

Nolen-Hoeksema 1991; Burns and Spangler 2000; Kazantzis studies, only the motivational scale predicted subsequent
et al. 2000). More broadly, the quality of the client’s engage- changes in depression (Burns and Nolen-Hoeksema 1991;
ment with treatment is critical to treatment outcomes Burns and Spangler 2000; Neimeyer et al. 2008). Although
(Orlinsky et al. 1994). these results were promising and robust across three stud-
Resistance and non-adherence may be secondary to, or ies, the length of the SHI reduced its usefulness in clinical
reflective of, low motivation or ambivalence about change settings, since 135 ratings of coping strategies are required.
(Burns 2005a; Engle and Arkowitz 2006). Most existing The goal of the present study was to examine the
measures of motivation reliably predict treatment dropout capacity of the brief Willingness Scale (WS) to predict
(Brogan et al. 1999; Dozois et al. 2004; Keijsers et al. changes in depression in psychiatric inpatients over short
2001; Soler et al. 2008) but not outcome. Some investi- time periods. Existing research has focused on outpatients
gators have reported significant relationships between during the first 12 weeks of treatment. In addition, we
measures of motivation and outcome (e.g., de Haan et al. wished to examine the value of the scale in a naturalistic
1997; Keijsers et al. 1994a, b) but others have not (e.g., treatment setting, where patients are struggling with a wide
Dozois et al. 2004; Kampman et al. 2008; Vogel et al. variety of disorders, since the findings might be more likely
2006). Consequently, despite the widespread recognition of to generalize to other clinical settings. Based on previous
the importance of motivation and resistance in common studies with the SHI, we expected that patients’ willingness
disorders such as anxiety and depression, adequate self- to engage in recommended coping strategies would predict
report measures of motivation are lacking. subsequent changes in depression.
Most studies of motivation have been conducted with
anxiety disorders, with surprisingly few investigators
examining motivation as a predictor of dropout or outcome Methods
in depression. Zuroff et al. (2007) reported that high scores
on a measure of autonomous motivation were associated Patients
with increased rates of improvement in three different
types of psychotherapy for depression. In three studies of The study included two cohorts of admitted patients to the
depressed outpatients receiving CBT, willingness to try psychiatric unit of Stanford University Hospital. The first
various coping activities predicted subsequent changes in cohort consisted of 69 patients who were recruited between
depression (Burns and Nolen-Hoeksema 1991; Burns and 2004 and 2006. The second cohort consisted of 91 patients
Spangler 2000; Neimeyer et al. 2008). In addition, patients’ who were recruited between 2006 and 2008. The study was
subsequent adherence with HW assignments mediated the approved for ethical conduct in research by both Stanford
effects of willingness on clinical improvement (Burns and University and the Pacific Graduate School of Psychology.
Nolen-Hoeksema 1991; Burns and Spangler 2000). Such Patients who were incapable of giving informed consent,
findings are also consistent other models of adherence and younger than 18 years of age, illiterate, unable to speak
illness coping behavior such as Leventhal et al.’s self- English, intoxicated, or delirious were excluded from the
regulatory model (1992), which has been applied to study. In addition, the inpatient team considered individu-
depression (Brown et al. 2007) and specifies a key role for als who were currently in seclusion or restraints, those with
perceived controllability in initiating coping behaviors. significant dementia, and those who were too symptomatic
The Self-Help Inventory (SHI) used in the Burns (Burns to complete questionnaires to be inappropriate to include in
and Nolen-Hoeksema 1991; Burns and Spangler 2000) and the study.
the Neimeyer et al. (2008) studies required patients to rate
45 coping strategies in three dimensions: 1. How often do Measures
you use this coping strategy when you’re feeling depres-
sed? 2. How helpful do you think this coping strategy Motivation
would be? 3. How willing would be to use this coping
strategy if suggested by a therapist or trusted friend? Thus, Motivation was assessed with the Willingness Scale (WS),
the SHI included a behavioral scale, a cognitive scale, and which was adapted from the willingness subscale of the
a motivational scale. In a cross sectional pilot study of SHI (Burns et al. 1987). The internal reliability of the
depressed women, all three subscales were correlated with original subscale was 0.95 (Burns and Nolen-Hoeksema
initial depression severity (Burns et al. 1987). Women who 1991; Burns and Spangler 2000), and previous research
were more severely depressed engaged in fewer coping with depressed outpatients supported its construct and
strategies, were less optimistic that coping strategies would predictive validity (Burns et al. 1987; Burns and Nolen-
be helpful, and were less willing to try coping strategies Hoeksema 1991; Burns and Spangler 2000; Neimeyer et al.
when depressed. However, in three subsequent longitudinal 2008). For this analysis, the author of the original WS

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selected eight items from the WS that were relevant to strong internal reliability, convergent validity, sensitivity
behavioral and interpersonal coping strategies. The abbre- and specificity, with a kappa value of 0.91 for the Mood
viated WS asks respondents whether they’d be willing to Disorder diagnostic variable when compared with the
try each of eight coping activities such as, ‘‘Try new ways diagnoses based on the SCID.
of relating to other people,’’ ‘‘Get started on a task I’ve
been putting off,’’ and ‘‘(F2) Face a problem I’ve been
avoiding.’’ The expanded response options range from Procedures
‘‘Definitely not’’ (0) to ‘‘Extremely willing’’ (4).
All patients referred to the study by the inpatient treat-
Depression ment team were contacted by a student researcher who
explained the purpose of the study and obtained consent.
Symptoms of self-reported depression were assessed with In the first cohort, diagnoses were determined using the
the Burns Depression Checklist (BDC; Burns 1997, 2006). EASY Diagnostic Survey (Burns 2005b; Burnett 2008)
The BDC was selected because it is has excellent internal followed by a systematic diagnostic interview. A subset
consistency and is brief and user-friendly, and focuses on the of 29 patients in that cohort also received a structured
specific symptoms of depression, rather than the more non- clinical interview for Axis I and II DSM-IV disorders
specific symptoms such as insomnia or changes in appetite. (SCID-I and SCID-II; First et al. 1997, 2002) in order to
The BDC asks participants to rate the intensity of five car- validate the EASY diagnoses. The SCID and EASY
dinal symptoms of depression: (1) sad or down in the dumps, interviews were conducted independently by different
(2) discouraged or hopeless, (3) low self-esteem, worth- student researchers who were unaware of the diagnoses
lessness, or inferiority, (4) a loss of motivation, and (5) a loss assigned by the other interviewer.
of pleasure or satisfaction in life. Response options for each In the second cohort, patients completed a revised and
item range from ‘‘Not at all true’’ (0) to ‘‘Completely true’’ condensed version of the EASY Diagnostic Survey (Burns
(4). The BDC correlates highly with other commonly used 2007). Research students reviewed the results of the
depression self-report scales including the Beck Depression survey and briefly interviewed each patient to ensure that
Inventory (r = 0.85 to r = 0.92), the Zung depression test the data were complete and reported accurately. Diagno-
(r = 0.87) and the SCL-90 Depression Scale (r = 0.89) ses were assigned according to the responses on the
(Hargrave and Sells 1997; Sekirnjak and Beal 1999; Marr EASY Diagnostic Survey and were summarized for the
2000). BDC scores are significantly correlated with mea- inpatient treatment team who were encouraged to finalize
sures of dysfunctional attitudes and hopelessness and are the diagnoses based on their clinical knowledge of each
sensitive indicators of change in depression during treatment patient as well as the DSM-IV diagnostic criteria.
with CBT (Westra et al. 2002). Patients in both cohorts completed the EASY Diag-
For this study, the motivation item was eliminated from nostic Survey along with the BDC and WS shortly after
the BDC to prevent any possible item overlap with the admission. Patients were encouraged to complete the
WS.1 The internal consistency (reliability) of the 4-item BDC again prior to discharge. Fifty-one percent of the
BDC scale was estimated in Structural equation modeling patients in both cohorts completed the brief follow-up
(SEM) using confirmatory factor analysis. The values were surveys. In most cases, failure to complete the follow-up
0.96 at both time points in cohort 1 and 0.94 at both times surveys was not due to a lack of cooperation but rather
in cohort 2. Total scores on the BDC were normalized to the abrupt nature of discharge from the inpatient unit and
range from 0 to 100 % to facilitate interpretation.2 the fact that student researchers were only available on
the unit to administer the surveys several times per week.
Diagnoses The times from initial to follow-up assessments in the
first and second cohorts were 3.88 days (SE = 0.52) and
The EASY Diagnostic Survey (Burns 2005b; Burnett 2008) 4.45 days (SE = 0.49), respectively.
consists of self-assessment tests for numerous Axis I and
Axis II disorders. Burnett (2008) has reported that the
EASY subscales for depression and mania demonstrate Treatment
1
All the analyses reported in this paper were repeated using the full The psychiatric inpatient unit at the Stanford Hospital
BDC, and the results were virtually identical to those reported here.
2
includes a voluntary and an involuntary unit. In both
In addition, this scoring system facilitates a rough comparison with
cohorts, 20 % of the patients were hospitalized involun-
other comparable tests. For example, the 21-item beck depression
inventory (BDI) ranges from 0 to 63. A score of 70 % on the BDC tarily. Length of stay is brief with the major focus on
would correspond approximately to a score of 43 on the BDI. biological interventions, such as medications. In addition,

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6.2 % of patients in the first cohort, and 7.8 % in the evaluate the stability of SEM estimates of the relationship
second cohort, were receiving electroconvulsive therapy. between willingness and changes in depression.
All patients were also encouraged to participate in daily
cognitive therapy groups as well as occupational therapy
and other activities.3 Results

Approach to Data Analyses Demographic and Diagnostic Profiles

SEM with the Analysis of Moment Structures (AMOS; As shown in Table 1, the mean age of the patients in both
Arbuckle 1994), Version 19.0, was used because of its cohorts was around 40. Approximately 70 % were female
ability to compare competing models using nested tests, and 41 % were married. Most patients were of modest
incorporate confirmatory factor structures, compare income with some post-secondary education. There were
parameter estimates across groups, and estimate missing no statistically significant differences between the two
data models using Full-Information Maximum Likelihood cohorts on any demographic variables. Ethnic composi-
(direct FIML; Arbuckle 1996; Burns and Spangler 2001; tions in the first and second cohorts were: Caucasian: 68.9
Wothke 2000).4 Only the v2 statistic was used to evaluate and 77.8 %; African-American: 9.8 and 3.3 %; Hispanic:
model fit, as suggested by Barrett (2007). Changes in v2 8.2 and 4.4 %; Asian: 9.7 and 7.8 %; and other ethnicities:
values relative to changes in degrees of freedom (v2 dif- 8.1 and 6.6 %. Table 1 also indicates that there was sub-
ference tests) were used to compare nested models.5 The stantial diagnostic co-morbidity in both samples. The
significance of model parameters was determined by majority of the patients had mood and/or anxiety disorders
examining the critical ratios (cr). LISREL 8.80 (Jöreskog and the diagnostic profiles in the two cohorts were similar.
and Sörbom 2006) was used for confirmatory factors The diagnostic profiles of the two cohorts can be seen in
analysis, to allow for analyses involving polychoric Table 2. There were no significant differences in the means
correlations. (point prevalence rates) of the EASY versus SCID diag-
Because causal models are not yet very highly refined in noses in cohort 1, where both instruments were adminis-
the behavioral sciences, some investigators have recom- tered. The kappa values for most of the SCID versus EASY
mended sensitivity testing in model evaluation (Burns and diagnoses indicated adequate therapeutic convergence
Spangler 2000; Leamer 1985). Sensitivity testing involves (Landis and Koch 1977). However, kappa values for GAD
introducing theoretically relevant variables into a model to and Drug Abuse or Dependence were low, due to the
assess changes in parameter estimates. The rationale is to higher values when diagnosed with the EASY system.
determine whether the inclusion or exclusion of these other Cronbach’s coefficient alpha for the EASY screening tests
variables will influence the parameter estimates. varied from a low of 0.89 and 0.87 for Bulimia Nervosa in
That’s because willingness could be a proxy for some cohorts 1 and 2, respectively, to a high of 0.98 and 0.97 for
other variable with strong causal effects on recovery from panic disorder in the two cohorts, indicating good internal
depression. To test this, a wide variety of demographic and consistencies.
diagnostic variables were included in the final model to
Mood and Motivation Variables

Since four of the WS items reflected interpersonal coping


3
strategies and four reflected behavioral coping strategies,
We do not have any empirical data on the extent of participation in
we hypothesized a two-factor structure. We tested this
the CBT groups.
4 model with a confirmatory factor analysis, stipulating two
This method provides efficient and consistent estimates for missing
data, even when the data are not missing completely at random. Three correlated factors and no correlations among the error
alternative methods of estimating models with missing data include terms for the observed variables. The model fit was not
mean substitution, listwise deletion, and pairwise deletion. These satisfactory, v2 (19, N = 160) = 54.03, p \ .001. There-
methods provide efficient and consistent estimates only under the
fore, we removed one item with the lowest loading from
stronger assumption that the data are missing completely at random.
5 each factor. This resulted in a significantly improved fit, v2
A nested test is a powerful and flexible method for comparing any
group of parameter estimates within groups or across groups. For (8, N = 160) = 15.87, p = .04. However, the modification
example, an investigator might wish to compare factor structures in indices suggested that one behavioral item (‘‘Get started on
two independent samples by declaring the parameter estimates to be a task I have been avoiding or putting off’’) shared a sig-
identical. A statistically significant increase in the Chi-square for the
nificant cross-loading with the interpersonal factor. This
nested model indicates that the hypothesis can be rejected, and that
the factor structures are not the same. In contrast, a negligible increase modification resulted in an excellent fit v2 (7, N = 160) =
in the Chi-square indicates the hypothesis can be accepted. 6.86, p = .44.

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Table 1 Patient characteristics in the two cohorts


Cohort 1 (N = 69) Cohort 2 (N = 91)
Mean SE Mean SE

Age (years) 42.49 1.97 39.84 1.68


Female (%) 69 6 71 5
Married or cohabitating (%) 41 6 41 5
Involuntary admission (%) 20 5 20 4
Education 3.75 0.16 3.79 0.14
Family’s annual income 4.68 0.50 5.01 0.41
Admission BDC 0.65 0.04 0.73 0.03
Discharge BDC 0.36 0.05 0.43 0.03
Willing Scale 1 0.73 0.03 0.73 0.02
Willing Scale 2 0.71 0.03 0.74 0.02
There were no statistically significant differences in any of the means of the demographic variables in the two cohorts
Education was assessed with the following categories: 0 = no formal education; 1 = grammar school; 2 = high school; 3 = some college or
technical training; 4 = college degree; 5 = some graduate school; and 6 = graduate degree
Income was assessed with the following categories: 0 = \$10,000; 1 = 10,001–20,000; 2 = 10,001–20,000; 3 = 20,001–30,000;
4 = 30,001–40,000; 5 = 40,001–50,000; 6 = 60,001–70,000; 6 = 70,001–80,000; 7 = 80,001–100,000; 7 = 100,001–150,000;
7 = 150,001–200,000; and 8 = [200,000
* p \ .001

Table 2 Diagnostic profiles in


Cohort 1 Cohort 2
the two cohorts
EASY SCID Kappa EASY
% (SE) % (SE) % (SE)

Mood disorders
Unipolar mood disordera 52 (6) 53 (8) .70 81 (4)***
b
Bipolar mood disorder 32 (6) 40 (8) .70 11 (3)**
Anxiety disorders
Generalized anxiety disorder 41 (6) 22 (8) .43 75 (5)***
Panic disorder w or w/o agoraphobia 30 (6) 43 (8) .69 39 (5)
Agoraphobia w or w/o panic disorder 24 (5) 26 (7) .73 26 (5)
There were no significant Simple phobia 29 (6) 14 (6) .54 34 (5)
differences in the means of the Social phobia 41 (6) 29 (8) .70 46 (5)
EASY versus SCID diagnoses Obsessive-compulsive disorder 22 (5) 15 (6) .62 30 (5)
in cohort 1. The EASY means in
cohort 2 were compared with Substance abuse
the EASY means in cohort 1 Alcohol abuse or dependence 29 (6) 29 (7) .57 18 (4)
a Drug abuse or dependence 38 (6) 26 (7) .47 24 (5)
Major depressive disorder or
dysthymic disorder Eating disorders
b
Bipolar I or II disorder Anorexia nervosa 9 (4) 14 (7) 1.00 9 (3)
c
No patients were diagnosed Bulimia nervosa 8 (3) 5 (4) .64 10 (3)
with schizophrenia using the
Binge eating disorder 12 (4) 5 (7) .61 16 (4)
SCID, so the inpatient treatment
team’s schizophrenia diagnoses Psychotic disorders
were used for comparison with Schizophrenia 8 (3) 4 (2)c .73 6 (2)
the EASY Personality disorders
* p \ .05; ** p \ .01; Borderline personality disorder 18 (5) 11 (5) – 35 (5)*
*** p \ .001

Given that the response options for these items consisted nature. Therefore, we re-ran the model using a polychoric
of five-point Likert scales, it could be argued that the covariance matrix, which assumes bivariate normal distri-
response data are ordinal—as opposed to continuous—in butions for each pair of observed variables. This model also

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Table 3 Correlations among the depression and motivation scales in the two cohorts
Cohort 1 Cohort 2
Initial Final Willing Willing Initial Final Willing Willing
BDC BDC Scale 1 Scale 2 BDC BDC Scale 1 Scale 2

Initial BDC 1.00 1.00


Final BDC .55*** 1.00 .61*** 1.00
Willing Scale 1 -.15 -.40** 1.00 .06 -.22 1.00
Willing Scale 2 -.15 -.46*** .57*** 1.00 -.09 -.27* .72*** 1.00
* p \ .05; ** p \ .01; *** p \ .001

provided an adequate fit to the data, v2 (7, N = 160) = The unstandardized factor loadings for the error terms were
11.29, p = .13. also set to 1.0 in both groups.
Based on this analysis, two Willingness Scales, called The fit of the measurement model was excellent in both
Willing Scale 1 and Willing Scale 2, were created, with cohorts, v2 (4, N = 160) = 4.56, p = .47.6 In a nested test,
total scores normalized to range from 0 to 100 %. There the four intercepts were set to be the same in the two
were no statistically significant differences in the means or groups, along with the three factor variances and covari-
variances of the two motivation scales at the initial eval- ances. In addition, the error variances for the two indicators
uation in the two cohorts, v2 (4, N = 160) = 3.03, for the Willing Factor were set to be the same within each
p = .55. In addition, there were no significant differences group to determine whether this factor had a parallel
in the means or variances of the 4-item BDC at the initial structure in each group.7 The increase in Chi-square was
evaluation or at discharge in the two cohorts, v2 (4, not significant, v2 (12 N = 160) = 8.53, p = .74, indi-
N = 160) = 4.05, p = .40. However, the mean depression cating that these additional restrictions were acceptable.
score at discharge (40.7, SE = 2.7, p \ .0001) in both The fit of the final measurement model was excellent, v2
cohorts was significantly lower than the mean depression (16, N = 160) = 12.30, p = .72.
score at the initial evaluation (70.0, SE = 2.4, p \ .0001), These results indicated that the Willing Factor was
v2 (1, N = 160) = 76.62, p \ .0001, with an average parallel in both groups. The Willing Factor was not sig-
reduction of depression severity of 42 %. The correlations nificantly correlated with depression at admission in either
among the depression and motivation scales in the two group but was negatively correlated with depression at
groups did not differ as a function of cohort v2 (6, discharge in both groups, r(160) = -0.44, p \ .0001. This
N = 160) = 8.11, p = .23 (see Table 3). meant that patients with higher WS scores at the initial
evaluation had significantly lower depression scores at the
Measurement Model second evaluation. In addition, the initial and final BDC
scores were positively correlated, as expected and
In a measurement model, the relationships among the r(160) = 0.65, p \ .0001, indicating that patients with
variables of theoretical interest are represented by corre- higher initial depression scores were more likely to have
lations. If the measurement model is successful, a variety higher final depression scores.
of causal models can be evaluated in order to test the The R-square values for Willing Scales were 0.59 in
hypotheses about the variables of interest. The measure- cohort 1 and 0.70 in cohort 2. The Willing Factor repre-
ment model in Fig. 1 was estimated in both cohorts sents the variance shared by two Willingness Scales in each
simultaneously. Circles represent unobserved variables group, and the two error terms represent errors of mea-
(factors and error terms) and rectangles represent observed surement as well as systematic variance that is not shared
variables (scale scores). One-headed arrows represent by the other Willing Scale. The outstanding model fit
causal effects, and two-headed arrows represent indicated that only the variance by the two Willing Scales
correlations.
The two willingness scales load on the Willing Factor,
6
and e1–e4 are the error terms for the observed measures. These values represent the sum of the Chi-squares values and
The Willing Factor was identified by setting one regression degrees of freedom in both groups, which were estimated
simultaneously.
coefficient to 1.0. The Initial and Final Depression Factors 7
A tau-equivalent factor has identical unstandardized factor load-
were identified by specifying their error variances so that
ings. A parallel factor also has identical error terms for all the
their R-square values would be identical to their estimated indicators. In a super parallel factor, all the indicators also have
reliabilities (0.96 and 0.94 in cohorts 1 and 2, respectively). identical intercept terms.

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Fig. 1 In this measurement


model, observed variables (e.g.
scale scores) are rectangles, and
unobserved variables are ovals
or circles. Two-headed arrows
represent correlations and one-
headed arrows represent causal
effects, and e1–e4 are error
terms. Standardized output
values are shown. The values
above the four observed
variables are R-square values.
The parameter estimates in the
second cohort were similar. The
correlation between the willing
and initial depression factors
was not significant in either
group. All other values were
significant at p \ .0001 in both
groups

(e.g. the Willing Factor) was correlated with Final Fig. 2 was estimated. In this model, the correlations linking
Depression Factor in each group. the Willing Factor with the initial and final depression
factors were replaced with two causal arrows in both
Causal Model cohorts. In addition, the correlation between the Willing
Factor and the initial depression factor was set to zero in
In order to learn more about the causal structure that might both cohorts. This model allowed estimation of the effect
account for the relationships among the Willing Factor and of the Willing Factor on changes in depression, by con-
the two depression scales, the structural equation model in trolling for the effect of initial depression on final

Fig. 2 In this causal model, the


correlation between the
willingness and initial
depression factor has been set to
zero in both groups. The values
above each observed variable
are the means of the scales. The
means of the unobserved
variables have been set to 0.
Path (regression) coefficients
are unstandardized estimates.
The value above the final dep
factor is the R-square. The
parameter estimates in the
second cohort were similar. All
parameter estimates were
significant at p \ .0001 in both
groups

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Cogn Ther Res

depression. Finally, all the parameter values were set to be depression were very similar to or even larger than the
identical in the two groups. results reported above.
The fit of this model was very good, v2 (17,
N = 160) = 13.98, p = .67. Together, the Willing Factor Missing Data Testing
and initial depression factor accounted for 55 % of the
variance in the final depression factor in both cohorts, SEM can produce consistent parameter estimates even
indicating good predictive validity. when missing data are not missing completely at random.
As expected, patients who were more depressed initially For example, if the patients with missing data were sig-
were more likely to be depressed at discharge, b nificantly more or less depressed or motivated at intake, the
(N = 160) = 0.58 (SE = 0.08), p \ .0001. The effect of the estimates for the means and variances of the final BDC in
Willing Factor on changes in depression was also large b both cohorts, as well as the causal effects of the Willing
(N = 160) = -0.55, SE = 0.15, p \ .0001. The negative Factor on changes in depression, would still be unbiased. In
value of the regression coefficient meant that patients with fact, the means and variances of the depression scale and
higher scores on the Willing Factor improved substantially the two willing scales at the initial evaluation were not
more than individuals with lower scores. Surprisingly, the size significantly different in the patients with and without
of the effect of the Willing Factor on changes in depression follow-up data in either cohort, and there were no signifi-
was similar to the size of the effect of initial depression on the cant differences in demographic variables such as age,
final depression when controlling for willingness. gender, marital status, income, education or voluntary
To confirm these results, the effect of the Willing Factor versus involuntary status in patients with and without fol-
on changes in Depression was set to zero in both groups. low-up data in either cohort. Nevertheless, the causal
The large increase in the Chi-square value indicated that model in Fig. 2 was estimated using only patients with data
this model could be rejected, v2 (1, N = 160) = 14.80, at both time points. The fit of the model was superb (v2 (17,
p = .0001. Then the effect of Initial Depression on Final N = 81) = 11.25, p = .85) and all of the parameter esti-
Depression was set to zero. The large increase in the Chi- mates were similar to those reported above using the
square value indicated that this model could also be complete data set. The result of this analysis is consistent
rejected, v2 (1, N = 160) = 39.62, p \ .0001. with missing data that are missing completely at random.
These findings indicated that the Willing Factor and the
Initial Depression Factors made strong additive and inde- Subgroup Analysis
pendent contributions to the prediction of the final depres-
sion scale. To illustrate the magnitude of the effect of the We included the entire sample in this analysis because we
Willing Factor on changes in depression, consider two wanted the greatest possible range on the Willingness and
individuals who are admitted to the inpatient unit with scores Depression scales so as to avoid range restriction problems.
of 70 on the depression scale, which was the mean for the Furthermore, our theory suggests that the relative presence or
patients in both cohorts. This score indicates moderate to absence of willingness predicts changes in depression
severe depression. However, their scores on the Willing symptoms in all patients, whether or not they have a diag-
Factor differ by 50 (90 and 40, respectively). This means that nosable mood disorder. However, we also did a subgroup
one patient is willing to try a variety of coping activities, but analysis with only those patients with a with a Mood Dis-
the second patient is reluctant. Their predicted discharge order diagnosis such as Major Depressive Disorder, Dys-
BDC scores can be calculated by this equation: thymic Disorder, Bipolar Disorder in the depressed phase,
and so forth. The model fit [v2 (17, N = 117) = 18.00,
Final BDC ¼ 41  ð0:55ÞðWilling Scale ScoreÞ p = .39] was excellent and the parameter estimates were
þ ð0:58ÞðAdmission BDCÞ similar to the values for the full sample. For example, the
unstandardized parameter estimate for the effect of the
The patient with the high initial willingness score will be Willing Factor on subsequent changes in depression was b
only minimally depressed at the second evaluation, with a (N = 117) = -0.67, SE = 0.21, p = .001, in both groups.
predicted depression score of 30, while the patient with the
low willingness score will have a predicted depression
score of 57, indicating very little improvement. Discussion
For the sensitivity analyses, a wide variety of demo-
graphic and diagnostic variables were introduced into the The current study indicated that the revised WS had
model as correlates of willingness and depression variables excellent predictive validity and suggests that patients’
at the initial evaluation. In all of these tests, the parameter willingness to engage in specific coping strategies may
estimates for the effects of the Willing Factor on changes in have strong effects on changes in depression, even over a

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brief course of inpatient treatment. High scores on the WS there was nothing unique about either willingness sub-scale
predicted greater improvement in depression, as predicted. (i.e., willingness to address relationship vs. personal
The measurement and causal models produced excellent problems) that predicted changes in depression—rather,
fits to the data in both cohorts, with no significant differ- what was important was the shared variance. Indeed, both
ences in the parameter estimates in either cohort, sug- willingness scales predicted change in depression equally
gesting that the findings were robust. Since there are very well when they were included separately in the model in
few variables in the world literature which have consis- place of the Willing Factor. This means that the specific
tently predicted changes in depression in inpatient and types of coping strategies on the WS may not be important
outpatient settings, these findings could have significant for symptom change. Instead, it may be that the willingness
implications for our understanding and treatment of this to engage in any potentially meaningful coping strategy
disorder. triggers improvement.
The WS was designed to capture a type of resistance Future studies should investigate how willingness
that Burns (2005a) has called Process Resistance. This influences outcome. While much of the improvement in
means that the patient may desire to recover but is reluctant depression could have resulted from a number of non-
to engage in the process that will be required for successful specific factors such as regression to the mean or respite
treatment. Process Resistance appears to be common from stressful circumstances, the scores on the WS still
among depressed individuals. For example, most CBT differentiated those who improved the most from those
therapists regard psychotherapy HW as an essential part of who remained the most symptomatic. Higher willingness
the treatment of depression, and research suggests that appears to be associated with higher HW adherence in
completion of psychotherapy HW assignments greatly outpatient settings (Burns and Spangler 2000) and may be
facilitates recovery (Burns and Nolen-Hoeksema 1991; associated with a more collaborative therapeutic alliance.
Burns and Spangler 2000). In spite of this, depressed Simply committing oneself to change may trigger some
patients are often reluctant to complete HW assignments degree of clinical improvement, perhaps through promot-
(Helbig and Fehm 2004; Kazantzis et al. 2000). As noted ing positive expectations or hope for change (Frank and
previously, studies with outpatients have indicated that the Frank 1991).
effects of the WS on changes in depression are, in fact, In addition, further research may elucidate variables that
mediated by HW adherence (Burns and Nolen-Hoeksema are associated with increased willingness which may be
1991; Burns and Spangler 2000). important in understanding how to help patients increase
However, it is unclear why willingness would be asso- their willingness to take active steps toward recovery from
ciated with rapid changes in depressive symptoms over the depression. It is possible that other variables not included
course of a brief inpatient admission, given the biological in this study, such as perceived controllability (Leventhal
orientation of the inpatient unit, and the sensitivity testing et al. 1992) or self-efficacy (Bandura 1997), may be
did not provide any hints that would help to answer this associated with willingness. Also, given that sudden gains
question. It is possible that depressed patients with high in the treatment of depression are often preceded by sub-
scores on the WS were more likely to attend the daily CBT stantial cognitive changes and are associated with superior
groups, which were voluntary, and that the CBT triggered recovery (Tang et al. 2005), studying such changes in the
the improvement. Since the data on group participation was context of motivational variables would be of interest.
not available to the investigators, this would be an Given its brevity and capacity to predict symptom
important area for future research. However, it is also change in depression, the revised WS could be used early
possible that the WS captures something that is crucial and in treatment to assess client motivation and identify indi-
basic to recovery, regardless of the setting or treatment viduals who may benefit from motivational interventions at
methods. One additional implication of the current findings the onset of treatment. In addition, the development of
is that the rather dramatic and rapid improvement in clinical methods to boost willingness during the initial
depressed patients with high WS scores was probably not phases of treatment for depression could be extremely
the result of the biological treatments the patients received, useful, as described by Burns (2005a). In addition, while
which presumably require several weeks to become Motivational Interviewing (MI: Miller and Rollnick 2002)
effective, but rather powerful and unrecognized psycho- has not yet been examined in the treatment of depression, it
social factors which may be captured, in part, by the WS. It has garnered empirical support in the treatment of sub-
was of interest in this regard that the ECT that 8 % of the stance abuse and health behavior change (for a review see
patients received was not associated with more rapid Hettema et al. 2005). MI is also being investigated in a
improvement. wide range of mental health problems beyond addictions
In the current study, willingness was represented by a (Arkowitz et al. 2008), including anxiety (Westra et al.
single factor. The excellent fit of the model indicated that 2009; Westra and Dozois 2006).

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The current study had several important strengths and Sample size is another potential limitation. While it would
limitations. In terms of strengths, all available newly- be desirable to replicate these findings with a larger sam-
admitted psychiatric inpatients were studied, not only those ple, it is encouraging that that identical results were
with a mood disorder diagnosis. Depression was also observed in two independent samples and that the findings
measured as a dimensional construct, using a reliable self- have been replicated in five inpatient and outpatient sam-
assessment instrument, rather than as a categorical con- ples with a combined N of greater than 650 patients (Burns
struct. The inclusion of continuous measures of depression et al. 1987; Burns and Nolen-Hoeksema 1991; Burns and
is important because it resembles how these constructs are Spangler 2000; Neimeyer et al. 2008.) In one previous
assessed in clinical settings. Moreover, the diversity of study of the effects of a brief mailed intervention on 177
patients and the high level of comorbidity of the sample, as mildly depressed college students, a modified Willingness
well as the naturalistic setting, suggest that these findings Scale was not correlated with subsequent changes in
will probably generalize to real world populations, depression (Geisner et al. 2006). However, these students
including severely distressed patients. were not seeking clinical care and the changes in depres-
Nevertheless, patients who were incapable of giving sion appeared to be extremely small, so it is difficult to
informed consent, younger than 18, illiterate, unable to interpret the results of that study.
speak English, intoxicated, delirious, or whom the inpatient Taken together, these results suggest that the WS pre-
team deemed inappropriate for participation in the studies dicts response to treatment in inpatient and outpatient
were excluded from this study. Additional research would settings. Since the revised, 6-item WS scale can easily be
be needed to test the assumption that willingness predicts completed and scored in less than 1 min, it may prove
change in depression among in these and other subgroups useful in identifying patients who may benefit from specific
not represented in the present or study. In addition, methods to reduce resistance and enhance motivation prior
although we found no evidence of systematically missing to engaging with more action-oriented methods such as
data at either time point, it is possible that those who did CBT. Further studies will be needed to determine whether
not complete the final assessment were different from those this new treatment strategy will substantially enhance the
who did. speed of recovery from clinical depression.
The information available from the current study is also
limited to the very short inpatient time frame. Although we Acknowledgments This authors wish to thank the following indi-
viduals who provided help or collaboration in the EASY Diagnostic
observe a trend in decreasing depression predicted by Research Study: Britney Blair, Debra Burnett, Psy.D., Kim Chu,
baseline willingness scores on average 4 days earlier, the Jennifer Coughlin, Katherine Claypool, Leigh Harrington, M.D.,
present data do not provide any information on long term Chris Hayward, M.D., Neda Kharrazi, Anthony Mascola, M.D.,
change in depression severity. However, numerous previ- Wendy O’Connor, Psy.D., Jonah Paquette, Psy.D., Lindsay Paquette,
Psy.D, and Debra Safer, M.D.
ous outpatient studies over 12 week periods of time have
produced nearly identical results. Further long term
research on the effects of willingness on changes in
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