Biomedical Research 2017; 28 (2): 539-548 ISSN 0970-938X

www.biomedres.info

Localization of neurodegenerative brain MRI image for gene expression

evaluation.
Babu Gopal*, Sivakumar Rajagopal
R.M.K. Engineering College, Kavaraipettai-601206, Tamil Nadu, India

Abstract
The soft computing techniques solve the major localization problems in optimization of biomedical
images. We have developed an automatic method aimed first at segmentation of MRI brain images by
denoising with Discrete Curvelet Transform. Then clustering of denoised images using Fuzzy C-means
clustering localized the abnormality by simulating the anatomical structure. The statistical analysis
confirmed the validity of the algorithm. The abnormality in localization compared with microarray gene
expression evaluation also showed variations which will be helpful for the development of gene module
based neuroimaging advancements.

Keywords: Neuro degeneration, Discrete curvelet decomposition, Spatial fuzzy clustering, Brain MRI image, Gene
expression evaluation.
Accepted on May 11, 2016

Introduction
Magnetic Resonance Imaging (MRI) is routinely used in the
diagnosis, characterization and clinical management of
neurodegenerative disorders of brain [1,2]. It is a dynamic non-
invasive diagnostic imaging tool that allows global assessment
of brain images and their interaction with their local
environment [3]. Noise is an ingrained phenomenon in the
medical images which may increase the root mean square error
and reduce the peak signal to noise ratio [4-7].
Curvelet based approach is used for the denoising of Magnetic
Resonance (MR) and Computer Tomography (CT) images [6].
Image fusion of MRI and CT images is also possible by this
analysis for better interpretation [7]. Curvelet transform is a
new multiscale representation suited for objects which are
smooth away from discontinuities across curves, which was
developed by Candies and Donoho [8] and this digital
transforms is applied for the denoising of some standard MR
and CT images embedded in random noise [9,10]. The
Curvelet reconstructions exhibit higher perceptual quality than
wavelet based reconstructions, offering visually sharper images
and, in particular, higher quality recovery of edges and of faint
linear and curvilinear features. Curvelets will be superior over
wavelets in the following cases [11]
• Optimal sparse representation in object with edges
• Optimal image reconstruction of severely ill-posed
problems
• Optimal sparse representation in wave propagators
Figure 1. Flow chart of discrete curvelet transform with spatial fuzzy
Since the brain images have several objects and curved shapes, clustering.
it is expected that Curvelet transform would be better in their
denoising [12].

Biomed Res- India 2017 Volume 28 Issue 2 539