Quarter 4 Honors Project Check In 1-This should be the first page of your group folder!

Parents: Liam and Brooke

Genetic Counselor: Hailey

Couple Letter: D

1. Baby info:
a. Child’s Gender: ​Female
b. Child’s Name: ​Lizzy Windsor Smith
c. Child’s parents: ​Brooke and Liam
2. What chromosomal abnormality is indicated on your ​karyotype​?
a. Describe how it appears on the karyotype. ​Three chromosomes (trisomy) on the
eighteenth chromosome pair​.
b. What disorder does it indicate? ​Edwards Syndrome
c. What are the symptoms of the disorder? ​Symptoms of this disorder are being fragile,
weak, and underweight. They have smaller heads and an upper lip cleft (Edward’s)
d. What is the prognosis for your baby with this disorder? ​Many children do not live past
birth or their first month of life. The small amount of children who do live, have
intellectual problems (Trisomy).
e. What treatments and/or assistance would be necessary? ​There is currently no cure, but
doctors can use surgery to treat some of the issues. Most treatments consist of using
medicines such as pain killers that don’t actually deal with the condition (Disabled).
3. What allelic disorder is indicated by your family history? Attach the pedigree that you created
based on your family history. Don’t forget that if there are carriers, you should shade them!
a. Based on your pedigree draw Punnett squares to predict the probability that your child
will also have the allelic disorder. ​Make sure that you state the probability after
completing the Punnett Squares! ​There is a 0% chance of their child having the allelic
disorder.
b. What are the signs and symptoms of this disorder? ​People that are infected with Marfan
syndrome are born with it, but they may not see the signs until later in life. Some of the
signs include long arms, legs, and fingers, tall and thin body type, curved spine, chest
sinks in or sticks out, flexible joints, flat feet, crowded teeth, stretch marks on the skin
that are not related to weight gain or loss (signs).
c. What treatments and/or assistance would be necessary for a child with this disorder?​ If
a child had this disorder, treatments needed are taking medication and having a more
relaxed- less active lifestyle. The child also needs to have regular doctor appointments
(Marfan Treatment).
4. Write out all possible Punnett Square(s) to predict your baby’s blood type. Explain why multiple
squares were or were not necessary.
PARENT BLOOD TYPES: Mother Type AB, Father Type A
 Multiple punnett squares were needed because the mother’s type A blood type was not
given as homozygous or heterozygous, causing us to have to consider all possibilities.

Punnett Square #1: I A I B x I A i

IA i Phenotype Possibilities (if mother is heterozygous):

IA I AI A I Ai 50% Type A 25% Type B

IB I AI B IBi 25% Type AB 0% Type O

Punnett Square #2: I A I B x I A I A

IA IA Phenotype Possibilities (if mother is homozygous):

IA I AI A I AI A 50% Type A 0% Type B

IB I AI B I AI B 50% Type AB 0% Type O

Total Blood Type Possibilities:

50% Type A - 12.5% Type B - 37.5% Type AB - 0% Type O

5. From the baby lab (Note: Do NOT attach your lab data to this. Instead, explain the information
as requested)
a. Choose 4 traits that are inherited by basic autosomal dominance or recessiveness.
1. Face Shape
2. Widow’s Peak
3. Eye Shape
4. Forehead Freckles
ii. For each trait, give the genotype and state whether it is homozygous dominant,
heterozygous, or homozygous recessive
1. ​Face Shape - AA genotype, homozygous dominant
2.​ Widow’s Peak - oo genotype, homozygous recessive
3.​ Eye Shape - tt genotype, homozygous recessive
4. ​Forehead Freckles - MM genotype, homozygous dominant
iii. State the baby’s phenotype
1. ​Face Shape - Round
2. ​Widow’s Peak - Absent
3. ​Eye Shape - Round
4.​ Forehead Freckles - Present
b. Choose 1 trait that is inherited by incomplete dominance.
1. Nose size
ii. Explain why this is considered to be incomplete dominance.
 This is incomplete dominance because a heterogeneous mix of E gives a
medium result.
iii. State the baby’s genotype and phenotype in your explanation
1. The babies genotype is E​1​, E​2​. The babies phenotype is medium sized nose.
c. Choose 1 trait that in polygenic.
Hair Color
i. Explain what polygenic means: ​Polygenic is when the trait is determined then
more than one gene.
ii. Explain how polygenic inheritance worked to give your baby his/her phenotype:
Polygenic inheritance gave the baby her phenotype in hair color. There were
many genes contributed from the mother as well as the father that, when the
dominants were counted, contributed to the overall hair color of the offspring.
iii. Be sure to include your baby’s genotype in your explanation
The baby’s genotype was HHIIJjKk (six dominants), giving it a dark brown hair
color (phenotype)
 Works Cited
“Treatment.” ​The Marfan Foundation​, 21 Sept. 2018, www.marfan.org/expectations/treatment.

“Trisomy 18 - Genetics Home Reference - NIH.” ​U.S. National Library of Medicine​, National

Institutes of Health, ghr.nlm.nih.gov/condition/trisomy-18.

Weiss, Thomas C. “Edward's Syndrome: Causes, Symptoms & Treatment.” ​Disabled

World​, Disabled World, 23 Mar. 2015,

www.disabled-world.com/disability/types/edwards-syndrome.php.

“What Are the Signs?” ​The Marfan Foundation​, 21 Sept. 2018, www.marfan.org/about/signs.