Ln C con

2.3287843306
1.5708860664
Via
2.1164745489
1.9131722729 3

1.3520792807 2.5
2.8176924462

Ln C Concentracion
2
2.6372374929 f(x) = - 0.0013515138x +
1.1319884498 1.5 R² = 0.0074708808
Err:509
1
1.9955657395
1.2108581368 0.5
2.1759906231
0
Err:502 0 20 40
0.6803382223

Ke=-m ke=0.0135 min-1

cpo=8.3095mg/ml
vd=2406.88ml
ClT=32.49 ml min
ABC=615.51 mg min/ml
t1/2=51.34 min
 Via Intravascular
3

2.5
Ln C Concentracion

2
f(x) = - 0.0013515138x + 1.9804161207
1.5 R² = 0.0074708808

0.5

0
0 20 40 60 80 100 120 140
Tiempo (min)
Via Extravascular
Tiempo (min) Concentracion (mg/ml) Tiempo (min)
Control Ln c Concentracion Control
0 1.191163846 3.2909090909 0
5 Err:502 -4.8181818182 5
10 -0.0755075525 0.9272727273 10
15 1.1225655297 3.0727272727 15
20 2.2012568409 9.0363636364 20
25 Err:502 -0.6 25
30 2.4272133336 11.3272727273 30
35 2.471176457 11.8363636364 35
40 2.4803508333 11.9454545455 40
45 1.1574527887 3.1818181818 45
60 1.7129785914 5.5454545455 60
75 1.4939250253 4.4545454545 75
90 Err:502 -4.1636363636 90
120 Err:502 -4.7818181818 120

Ke=-m Ke=0.0047 min-1 2.9779096151

Cp0=e cp=3.8444mg/ml Err:502
vd=d/cp vd=5202.37ml -0.1887688813
F=7.4948 2.8064138242
Vd=512101.42 5.5031421022
Cp max=0.02726 Err:502
tmax=277.15 6.0680333339
t1/2=147.4781 6.1779411424
Clt=24.4511 6.2008770831
8.6808959152
12.8473394353
11.2044376898
Err:502
Area bajo la curva 62.27822126
Ln c Concentracion Absorbancia
0
1.191163846 0.318
Err:502 0.095
-0.0755075525 0.253
1.1225655297 0.312
2.2012568409 0.476
Err:502 0.211
2.4272133336 0.539
Via Extravascular
2.471176457 0.553
2.4803508333 0.556 3

1.1574527887 0.315 2.5

f(x) = 0.010709693x + 1.2648376987
1.7129785914 0.38 R² = 0.0919690382

Ln c Concentración
2
1.4939250253 0.35
Err:502 0.113 1.5

Err:502 0.096 1

0.5

0
0 20 40 60 80 100 120
-0.5
Tiempo (min)

149896 0.828614

-0.3951
xtravascular

48376987

60 80 100 120 140

Tiempo (min)
Via extra

Ln C extrapolada C extrapolada
1.3467 3.8447
1.3232 3.7554
1.2997 3.6681
1.2762 3.5829
1.2527 3.4997
1.2292 3.4184
1.2057 3.339
1.1822 3.26185

Ka=0.0027 min -1
Ln C=1.3467-0.0047 t

Cp (Cextra-cp) Tiempo min

3.2909 0.5538 0
0 3.7554 5
0.9272 2.7409 10
3.0727 0.5102 15
9.0363 -5.5366 20
0 3.4184 25
11.3272 -7.9882 30
11.8363 -8.57445 35

ln(Cextra-Cp) VS Tiempo
1.5

f(x) = 0.032620594x + 0.1005233865

1 R² = 0.0978077709

0.5
Ln c

0
0 5 10 15 20 25 30 35 40

-0.5

-1
Tiempo (min)
ln(Cextra-Cp)
-0.5909516682
1.3231948042
1.0082863336
-0.6729524733
Err:502
1.2291726053
Err:502
Err:502
Via Intravascular
Tiempo (min) concentracion Absorbancia
Control 0
0 10.2654545455 0.508 0
5 4.8109090909 0.358 5
10 8.3018181818 0.454 10
15 6.7745454545 0.412 15
20 3.8654545455 0.332 20
25 16.7381818182 0.686 25
30 13.9745454545 0.61 30
35 3.1018181818 0.311 35
45 7.3563636364 0.428 45
60 3.3563636364 0.318 60
75 8.8109090909 0.468 75
120 1.9745454545 0.28 120
Ln C Chart Title
18
2.3287843306 16
1.5708860664
14
2.1164745489
12
1.9131722729
1.3520792807 10
2.8176924462 8
2.6372374929 6
1.1319884498 4
1.9955657395
2
1.2108581368
0
2.1759906231 0 20 40 60 80 100
0.6803382223
Via Intravascular
3

2.5

2 f(x) = - 0.0094425049x + 2.1738141467

R² = 0.2523094363
1.5
Ln C

0.5

0
0 20 40 60 80 100 120 140
Tiempo min
 Chart Title

40 60 80 100 120 140

100 120 140

 0 3.29090909 0.318 1.191163846
10 0.92727273 0.253 0 -0.0755075525 Char
15 3.07272727 0.312 15 1.1225655297
3
20 9.03636364 0.476 20 2.2012568409
30 11.3272727 0.539 30 2.4272133336 2.5
35 11.8363636 0.553 35 2.471176457
2 f(x) = 0.0126155653x + 1.2171589944
40 11.9454545 0.556 40 2.4803508333 R² = 0.1159375319
45 3.18181818 0.315 45 1.1574527887 1.5
60 5.54545455 0.38 60 1.7129785914
75 4.45454545 0.35 75 1.4939250253 1

0.5

0
0 10 20 30
-0.5

Chart Title
14

12

10
Concentracion

8
f(x) = 0.0302702703x + 5.4628992629
6 R² = 0.0280622921
4

0
0 10 20 30 40 50 60 70 80
Axis Title
 Chart Title

= 0.0126155653x + 1.2171589944
0.1159375319

10 20 30 40 50 60 70 80
 0 1.19
15 1.12
20 2.2
30 2.42
35 2.47
40 2.48
45 1.15
60 1.71
75 1.49 Via Extravascula
3

2.5

2
f(x) = 0.0019144737x + 1.7352631579
1.5 R² = 0.0054939396

Ln C
1

0.5

0
0 10 20 30 40
Tiempo (min)
 Via Extravascular

= 0.0019144737x + 1.7352631579
0.0054939396

10 20 30 40 50 60 70 80
Tiempo (min)