DATE: June 8 1988 U.S. ARMY CHEMICAL Emergency Telephone #5: RESEARCH, DEVELOPMENT CRDEC Safety Office AND ENGINEERING CENTER 301-671-4411 0800-1600 EST After normal duty hours: 301-278-5201 Ask for CRDEC Staff Duty Officer MATERIAL SAFETY DATA SHEET SECTION I - GENERAL INFORMATION MANUFACTURER'S NAME: Department of the Army MANUFACTURER'S ADDRESS: U.S. ARMY ARMAMENT, MUNITIONS AND CHEMICAL COMMAND CHEMICAL RESEARCH DEVELOPMENT AND ENGINEERING CENTER ATTN: SMCCR-SFS ABERDEEN PROVING GROUND, MD 21010-5423 CAS REGISTRY NUMBER: unknown CHEMICAL NAME: 1-methy1-4~piperidyl isopropylphenylglycolate TRADE NAME AND SYNONYMS: EA 38348 N-Methy | -p T pee ayl mec : Glycolié,Fster i oopvee yl pl cay felyes FORMULA/CHEMICAL STRUCTURE: C17 H25 N 03 hess CHEMICAL FAMIL| NFPA 704 SIGNAL: Health ~ 4 NN Flammability - 1 an Reactivity - 0 NN 4 INGREDIENTS FORMULA, PERCENTAGE TLV NAME BY WEIGHT EA 3834B C17 H26 N 03 100 * * None established/availableBOILING POINT DEG F (DEG ¢): 231 DEG C (extrapolated) VAPOR PRESSURE (mm Hg): 1.5 ¥ 10-5 at 25 DEG C VAPOR DENSITY (AIR=1, SOLUBILITY (g/100g solvent): a. Water (distilled): <0.002 @ 25 DEG C b. Best Solvent: n-hexane 74.9 diethyl ether 84.8 SPECIFIC GRAVITY (H20=1): 1.08 : FREEZING (MELTING) POINT: 48.8 DEG C AUTOIGNITION TEMPERATURE DEG F (DEG C): Not Available VISCOSITY (CENTISTOKES): 13525 @ 25 DEG C (supercooled liquid) SOLID DENSITY: Not Available APPEARANCE AND ODOR: White crystal solid (pure) to brown oil (impure) SECTION IV - FIRE AND EXPLOSION DATA FLASHPOINT (METHOD USED): 203 DEG C (Open cup) FLAMMABILITY LIMITS (% by volume): Not available SPECIAL FIRE FIGHTING PROCEDURES: Use NIOSH approved pr for fire-fighting. UNUSUAL FIRE AND EXPLOSION HAZARDS: Not available. SECTION V - HEALTH HAZARD DATA PERMISSIBLE EXPOSURE LIMIT: Data is not available to support @ propo ed, permissible exposure limit. EFFECTS OF OVEREXPOSURE: EA 3834B is a parasympathetic depressant affecting the central nervous system as well as the organs of circulation, digestion, salivation, sweating and vision. Its pharmacological action blocks ac etylcholine centrally and peripherally like atropine, with psychotomimetic Sctivity, EA 3834B has more central potency than atropine. Median Lethal Dosage, Animals: LpS0 (intravenous, mouse) = 43.1 mg/kg 24=hr [ps0 (intravenous, rabbit) = 30.1 mg/kg 24-hr Lp50 (intravenous, cat) = 1.0 mg/kg 24-hr 1050 (intramuscular, mouse) = 0.64 mg/kg 24-hr Minimum Effective Dosage, Man:MEDSO (intravenous, man) = 0.00174 ng/kg (calculated) ACUTE PHYSIOLOGICAL EFFECTS (initial symptoms) include increased heart rate, ‘Tightly elevated blood pressure, moderately dilated pupils, slightly blurred Seaeey Sleepiness, slight dryness of mouth, dullness in mental processes, vision, o1eeP contact with reality. Moderate symptoms include rapid heart Pete, dry lips, mouth, and skin; elevated temperature, sedation, fleeting Tiicbions or hallucianations, brief lapses in concentration, transient ainfGsion, dizziness, vomiting. Signs of severe symptoms are | Very rapid conee et eate, high blood pressure, dry lips, mouth, and skin; disturbances in performance, memory, and attention, incoherent speech, delirium, vomiting, peter, dizziness, staggering, prostration, sedation, stupor, and coma. qThe incapacitated person mumbles to himself, picks at specks on, the floor, es fails to comprehend or respond to simple questions or instructions. He eta Sicigce couch gand: (unevare™. = LatermNelieremnesic| toy moet of his ex- perience. The most noticeable peripheral autonomic effects are dry mouth pei mydriasis, which may persist after the delirium has cleared. CHRONIC PHYSIOLOGICAL EFFECTS (monkeys). Intravenous daily doses of EA Se34B given 20 times in 4 weeks to groups of male and female monkeys pro- duced the following effects: 0.010, 0.2, and 1.0 mg/kg Decreased locomotor activity and ataxia. 0.1 and 2.0 mg/kg Increased or decreased respiratory depth, increased respiratory, rate mydriasis, and deoret aggres~ siveness. 1.0 mg/kg Anorexia EMERGENCY AND FIRST AID PROCEDURES: INHALATION: Immediately. remove from exposure. Seek medical attention immediately. If breathing is irregular or has stopped, start resuscitation and administer oxygen. EYE CONTACT: Flush out eyes with saline solution to prevent absorption’ through mucous surfaces (15 minutes). Do not rub eyes. Beek medical attention immediately. SKIN CONTACT: Wash skin with soap and water to prevent absorption through abrasions and skin, or orally by ingestion. | If wa hing is imposs- ible, absorbent powder in the skin decontamination pad of the M13 kit may be beneficial. If a large quantity is on skin, add solution by waghing with 1 N. hydrochioric acid and then with water. Seek medical attention immediate ly. INGESTION: Cleansing the mouth with an astringent swab may be comfort ing and will reduce the foul breath associated with parching of the mem- ednes. “Fluids should be given sparingly because of the danger of vomiting ved also because of the likelihood of temporary urinary retention. Turn patient on their stomach with head to side to avoid aspiration in case of periting. DO NOT induce voniting. Seek medical attention immediately. CAUTION: If body temperature is elevated above 102 DEG F and mucous