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DOI: 10.1159/000314319
GCs
IRS-1
GLUT4
GCs
PI3K
GCs
GCs
GSK-3 PKB/Akt
Fig. 2. Effects of GCs on the insulin recep- GCs
tor signaling pathways. GC indicates the
processes inhibited by GC excess. IRS-1 =
Insulin receptor substrate-1; PI3K = phos- Glycogen
GS
phatidylinositol-3-kinase; PKB = protein synthesis
kinase B; GSK-3 = glycogen synthase ki-
nase-3.
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