Assembly and disassembly

instructions for GeneXpert IV R2

Delivering a Better Way V15 – 1/31/11

GeneXpert IV R2

2 © 2010 Cepheid
GeneXpert IV – Summary of steps

• Unplug system and remove all cartridges

• Remove the back cover and pull out the device

• Remove the cover on top of the device

• Remove motherboard

• Remove the I-CORE module

• Reassemble

• Questions or issues
3 © 2010 Cepheid
GeneXpert IV – Points to consider

• Separate screws at each step to ensure they return

to the appropriate place upon reassembly
• Take care of trapping cables at each step
• Do not use an electric screwdriver or over tighten
the small screws as they damage easily
• Do not over tighten the feet as this will cause the
doors to become difficult to open and close
• Be sure to reconnect to computer following
reassembly to test connections
4 © 2010 Cepheid
 Unplug system and remove all cartridges
1.1 1.2

1.1 : Make sure the device is switched off and unplugged

1.2 : Make sure all cartridges are removed from the GeneXpert IV
Note: if cartridges spill inside the instrument the module will need to be replaced

Required tools: a b c d
a) Electrostatic
Discharge
(ESD) wrist
strap
b) Screwdriver
c) Wrench or
spanner
d) Pliers
5 © 2010 Cepheid
Remove the back cover and pull out the device

2.1 2.2 2.3a 2.3b

2.1 : Remove all 3 screws from each foot underneath the GeneXpert. This can be done by carefully
placing the instrument upside down

Note: ensure that there are no cartridges in the instrument. If cartridges spill inside the instrument
the module will need to be replaced

2.2 : Return the instrument to the right way up then remove all four screws from the back cover. If
necessary, pliers can be used to remove back cover by gripping the area indicated above. Avoid using the
fan vent below as this can cause damage to the fan

2.3 : Carefully pull the device out of the outer casing while pushing on the doors of the device

See warning on following slide

6 © 2010 Cepheid
Caution: Sharp edges!

CAUTION: The corners indicated below are

sharp and can cause injury if care is not taken

7 © 2010 Cepheid
 Remove the cover on top of the device
3.1a 3.1b

3.3

Disconnect
these 3
3.2a 3.2b cables

3.1 : Remove the cover on top of the device by removing all 8 screws (4 on each side)

3.2 : Remove the 5 screws from each side and the 3 from the base at the rear. Note that the screws are very small
and fragile. Please handle with care and be sure to use a manual screwdriver only

3.3 : After removing all screws please pull the cover back taking care not to damage the cables inside. Disconnect
the three cables to completely remove the back
8 © 2010 Cepheid
Remove motherboard

4.1 4.2
4.1 : Unscrew both
screws on each side to
remove the motherboard

4.2 : Remove all cables

that are connected to
the motherboard

4.3 4.4
4.3 : Carefully pull the
motherboard out of the
device

4.4 : Remove black and

red cable

9 © 2010 Cepheid
Remove the I-CORE module

5.1 5.2a 5.2b

5.1 : Unscrew both screws on top of the I-CORE module you want to remove until they are held in place
only by the spring. To avoid damage do not fully remove the screws

5.2 : Remove the nut that holds the module in place. Note that the nut can be removed by hand in most
cases but if it is tight it is advised to use a wrench (nut size is 3/8”)

10 © 2010 Cepheid
Remove the I-CORE module

6.1a 6.1b 6.1c

6.1 : To remove the module, push in the door while tilting the module back

6.2 : Take care not to put your finger inside the opening at the top of the module as this can cause
serious damage

6.2a 6.2b

X X
11 © 2010 Cepheid
I-CORE module

- This is how the I-CORE module looks after it has been removed from the GeneXpert
- Note the new I-CORE modules for the GeneXpert R2 lack of the support frame that
was present on the GeneXpert R1 modules

R2 module R1 module

12 © 2010 Cepheid
Reassembly – Replacing I-CORE module

- In order to reassemble the GeneXpert, simply reverse the steps taken during disassembly
- However, please take note of the following steps and tips to ensure the instrument is correctly
reassembled
- Once again, take care of not crushing cables at each step and avoid over tightening the
screws

- When reinserting the module it is necessary to again tilt the module and ensure that the door
goes over the metal tab and that the black plastic base of the module comes through the hole

Door
Metal tab
Plastic base and hole

13 © 2010 Cepheid
Reassembly – Replace outer case

- When reinserting the instrument into the outer

casing it is easier to place the instrument carefully
on its back, then lower the casing over it

- Due to ridges on the inside of the outer casing it

may be necessary to gently pull out the sides of
the casing as it is lowered over the instrument

14 © 2010 Cepheid
Reassembly – Check doors

- Following reassembly, if the doors become difficult to open or close (there will be a clicking
noise and feel) then this indicates that the front feet have been replaced too tightly

- To solve the problem simply slightly loosen the screws on the front feet of the instrument until
the door operates freely

15 © 2010 Cepheid
Reassembly – Check connection

- When reassembly is completed it is necessary to reconnect the instrument to the computer

and test that all modules are working and recognised by the computer

- The software will display each module as Available if all connections are good

- If the software cannot detect one or more modules then this indicates that there is a problem
with one or more of the connections

16 © 2010 Cepheid
Questions or Issues

- If you experience any issues or problems when

dealing with the new GeneXpert R2, please don’t
hesitate to contact Cepheid Technical Support

- Email : support@cepheideurope.com

- Phone : +33 563 825 319

17 © 2010 Cepheid