1. Biopharmaceutics: The study of factors that influence the process of drug absorption, distribution, metabolism and elimination in the body. 2. Absorption: The process of movement of unchanged drug from the site of administration to the site of measurement. i.e. plasma. 3. Distribution: The reversible transfer of drug between the body compartments. 4. Metabolism: The chemical conversion of drug from one form to another which may be active or inactive, in the body. 5. Elimination: The irreversible loss of drug from the body is called Elimination. It consists of two processes, Metabolism (Biotransformation) and Excretion. 6. Excretion: The process where drugs and their metabolites are irreversibly transferred from internal to external environment. 7. Bioavailability: The rate and extent of absorption of drug in the body. 8. Half life: The time required for the concentration of drug to decrease by 50% of the initial value. 9. Elimination rate constant: It is the value which shows the elimination of drug per unit time. 10. Volume of distribution: The ratio of amount of drug in the body to the plasma drug concentration. 11. Clearance: The theoretical volume of body fluid containing drug from which the drug is completely removed in a given period of time. 12. Therapeutic index: The ratio of maximum safe concentration to the minimum effective concentration. 13. Peak plasma concentration: The point of maximum concentration of drug in plasma is called the peak and the concentration of drug at peak is called Peak plasma concentration. 14. Time of peak concentration: The time for drug to reach the peak concentration(after extravascular administration) in plasma. 15. Area under the curve (AUC): It represent the total integrated area under the plasma level- time profile and expresses the total amount of drug that comes in to the systemic circulation after its administration. 16. Maximum safe concentration (MSC): The concentration of drug in plasma above which unwanted/toxic effects occur. 17. Minimum effective concentration (MEC): The minimum concentration of drug in the plasma required to produce the therapeutic effect. 18. Therapeutic range: The drug concentration between MEC and MSC. 19. Onset of action: The beginning of pharmacological action. 20. Onset time: The time required for the drug to start producing the pharmacological effect. 21. Dosage regimen: The frequency of administration of drug in a particular dose. 22. Bioequivalence: A relative term that denotes that the drug substance in two or more identical dosage forms, reaches the systemic circulation at the same relative rate and to the same relative extent.
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