Neuroinflammation and Alzheimer’s disease

Get to the root cause of neurodegeneration with these tools

Amyloid beta
Aβ peptide Quickly induce neurotoxicity and neurodegeneration
ab120301
(1-42) with this high purity Aβ fragment.
Aβ clearance Active Release of proinflammatory mediators
Image Aβ in real time with this non-toxic, cell-permeable
microglia IL-1β, IL-6, TNFα, IFNγ, MIP-1α, MIP-1β, RANTES, MCP1, M-CSF CRANAD-58
probe suitable for in vitro and in vivo imaging.
ab146926

To find out more about amyloid beta probes, visit www.abcam.com/amyloid-probes

TREM2
Tau
Migrating
Anti-Tau
microglia Quickly detect phospho S396 tau with this versatile
Aβ plaque Synapse (phospho S396)
antibody
antibody. Available in 10 μl trial format.
ab109390

Reactive loss Target tau tangles and facilitate aggregate clearance

astrocytes LMTX
Neuronal with this tau aggregation inhibitor.
ab223882

GFAP damage To learn about other products to study tau, visit www.abcam.com/tau

and death Clq C3 Glia

Distinguish microglia from macrophages and other
Anti-TMEM119
immune cells with this stable and specific microglial ab209064
antibody
marker.
Tau neurofibrillary
tangles (NFTs) CR3 Anti-GFAP Effortlessly label astrocytes with this highly-cited astrocyte
ab7260
MCP-1 antibody marker.

gradient For more help choosing neural markers, visit www.abcam.com/glia

Amyloidogenic
Proinflammatory mediators
APP processing Caspase 3
Aβ GSK3β Mouse TNF Detect proinflammatory mediators, such as TNF-alpha, in
ab208348
alpha ELISA Kit just 90 minutes with a SimpleStep ELISA® kit.
Caspase 7
To discover the range of SimpleStep ELISA kits, visit www.abcam.com/simplestep-elisa

β-secretase Microglial Mouse and

human key
Profile multiple cytokines at once with a multiplex panel ab213392
or design your own. ab213397
complement cytokine panels
γ-secretase Tau paired helical
P
filaments (PHFs) activation To learn more about Fireplex immunoassays, visit www.abcam.com/fireplex-immunoassays
Cdk5 Cdk5

p35 p25

Calpain
AICD Ca2+
Ca2+ Ca2+
Blood brain C99 Ca2+
P P Oligomeric Ca2+ Axon terminal
barrier APP Tau Ca2+
Proteosomal P P
degradation P P P P P Glutamate
P Soluble Aβ
P
P P P P NMDA oligomer
Ubiquitin P P
P receptor
P P P P P P P
P AMPA
CCR2 P P P
P P P receptor
gradient P P P
Ca2+
Autophagy P P P P
P Ca2+ Membrane
Tau mislocalization P damage
Ca2+
to dendritic spine FYN
PSD95
Ca2+
Infiltration of monocytes Tau Ca2+
and macrophages hyperphosphorylation Ca2+
ROS

Tau on FYN P
Ca2+ Apoptosis
microtubules P P
FYN
P
Tau P P
P P
Ca2+ overload
P

Dendritic spine
Axon

To find out more, please visit www.abcam.com/neuroinflammation

Copyright © 2017 Abcam, All rights reserved. Poster compiled with help from Dr John-Ioannis Sotiropoulos, ICVS.