UNIVERSITI TUNKU ABDUL RAHMAN

CENTRE FOR FOUNDATION STUDIES

FOUNDATION IN SCIENCE

PREVIOUS USED AS:

TUTORIAL 12 OF BIOLOGY I JAN 2017

NOW USED AS:

TUTORIAL 2 OF BIOLOGY II JAN 2018
REVISION OF TEST 1

MENDELIAN GENETICS II

Student’s Guide:
At university level, the tutor facilitates student learning without spoon-feeding. Therefore,
you are expected to:
1. Read your textbook, attempt the questions before the tutorial
2. You may enter the class and sign your attendance after showing your tutor that all
tutorial questions have been completed
3. Write answers on board if you wish to receive tutor feedback (no answer, no
feedback)
4. Be independent: consult textbooks or dictionaries on your own first before asking the
tutor
All questions are compulsory. 1 mark reflects 1 answer point. (No half mark is awarded
in the exam).

(Source: Final Examination, Apr 2012)

Q1. (a) Figure 1.1 is a pedigree showing the inheritance of sickle-cell disease. Sickle-
cell disease is an autosomal disorder characterized by the presence of sickle-
shaped red blood cells. Let the dominant allele be represented by N and
recessive allele be represented by n.

Figure 1.1

(i) State the possible genotype(s) of individuals 4, 8 and 14. (3 marks)

 (ii) Individual 6 was married to individual 11. Using a Punnett square,
explain all the possible genetic combinations in their children.
(3 marks)

(iii) State the probability that the next TWO children of couple 3 and 4 will
be affected. Show your calculation. (1 mark)

(Source: Final Examination, Dec 2016, truncated)

Q2. Figure 2 shows the inheritance of thalassemia in a family. Squares represent males
and circles represent females. Shading indicates thalassemic individuals. Let T
represents the dominant allele and t represents the recessive allele.

Figure 2

(a) State all the possible genotype(s) for individuals 2, 6 and 10. (3 marks)

(b) State the mode of inheritance for thalassemia. Justify your answer. (3 marks)
 (c) Using a Punnette square, list all the possible genotypes of their children if
individual 9 marries a thalassemia carrier. (2 marks)

(Source: Final Examination, Dec 2013, truncated)

Q3. Pedigree in Figure 3.1 shows the presence of individuals bearing extra fingers and
toes exhibiting "polydactyl". The affected individuals are shown shaded. Let the
dominant allele is represented by P and the recessive allele is represented by p. None
of the marriage partners from outside these two families are heterozygous for the trait.

Figure 3.1
(i) Based on Figure 3.1, state the type of genetic inheritance of this trait.
(1 mark)

(ii) State the genotypes for individual no. 8, 9 and 10. (3 marks)

(iii) If individual no. 10 is mated with a person who is heterozygous for this
trait, what is the probability of them producing an affected offspring?
(1 mark)
(Source: Final Examination, Apr 2014)
Q4. The Human ABO blood group phenotypes involve three alleles for a single gene.
Figure 4.1 shows a pedigree of ABO inheritance.

Couple I Couple II

Individual I O
Couple III
Individual II

Individual III
Figure 4.1

(a) Based on the pedigree in Figure 4.1, find the genotype(s) of the following
individuals:

(i) Individual I (1 mark)

(ii) Individual II (2 marks)

(iii) Individual III (2 marks)

(b) State the couple(s) in Figure 4.1 who are able to produce off-springs with all
possible blood groups. Support your answer by illustrating the cross using a
Punnett square. (7 marks)