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HACCP is a management system in which food safety is addressed through the analysis and control of
biological, chemical, and physical hazards from raw material production, procurement and handling, to
manufacturing, distribution and consumption of the finished product. For successful implementation of a
HACCP plan, management must be strongly committed to the HACCP concept. A firm commitment to HACCP
by top management provides company employees with a sense of the importance of producing safe food.
HACCP is designed for use in all segments of the food industry from growing, harvesting, processing,
manufacturing, distributing, and merchandising to preparing food for consumption. Prerequisite programs
such as current Good Manufacturing Practices (cGMPs) are an essential foundation for the development and
implementation of successful HACCP plans. Food safety systems based on the HACCP principles have been
successfully applied in food processing plants, retail food stores, and food service operations. The seven
principles of HACCP have been universally accepted by government agencies, trade associations and the food
industry around the world.
HACCP Summary: Created on November 3rd, 2007. Last Modified on November 3rd, 2007
Why Human is a Living Organism?
(1) All living organisms are made of cells, which are the units of life. A cell comprises a plasma
membrane consisting of a phospholipid bilayer (see Chapter 2, Fig. 2-4). There are various kinds of
cells, from liver cells, which are several dozen micrometers in diameter, to nerve cells, which are
several meters long.
The smallest size visible through the naked eye is generally about 0.1 mm (100 µm) and through a
light microscope is about 0.2 µm (200 nm); anything less than 1 µm cannot be seen clearly without an
electron microscope. However, living organisms cannot be observed using an electron microscope.
(2) Another obvious major characteristic of living organisms is that they produce offspring that are the
same as themselves. Unicellular organisms under normal nutrition conditions produce offspring
by asexual reproduction, such as by dividing(protozoa, etc.) or budding (baker's yeast). In
a sexual reproduction, the cells of the offspring have the same traits as the cells of their parents
(the characteristics that surface) as long as their DNA does not mutate. Multicellular organisms,
however, undergo sexual reproduction and produce offspring that inherits half of each parent's genes.
The genetic material (DNA) of both humans and bacteria is similar in that it consists of four bases—
adenine, guanine, cytosine, and thymine—which are the characters in the DNA code, but differences
between the DNA of these organisms are produced by the differences in the ratios of these bases.
The fact that these organisms share the same genetic material is evidence for the assertion that all
organisms on the earth evolved from a single organism.
However, if a mutation occurs in DNA during self-replication, it is sometimes expressed in the traits of
the offspring. The bases of DNA change randomly at a constant rate, and the resulting evolution can
also be considered a characteristic of living organisms (see Column at the bottom).
(3) The third characteristic of living organisms is their response to stimuli. The plasma membrane
contains proteins called "receptors," which receive stimuli from the outside environment
When outside stimuli such as chemical substances or heat reach the receptors, a series of various
chemical reactions occurs in the cytoplasm. Finally, DNA is transcribed and new proteins are
synthesized. This system of chain reactions is called "signal transduction" (see Chapter 7). Genes for
various receptors are present in the genes of all living organisms, from Escherichia coli bacteria to
humans. These organisms have many receptors in common, such as potassium channels through
which potassium ions travel. The abundance of common receptors also suggests that all living
organisms on the earth evolved from a single primitive organism.
(4) The final characteristic of living organisms is that they carry out metabolism (synthesis and
degradation of substances) in their cells (see Chapter 8). Metabolism is a process in which
organisms synthesize ATP to store energy, and then release that energy by hydrolysis, obtaining
heat in the process.