Pathology MCQs

1. In hypoxic cell injury, cell swelling occurs because of increased intracellular:

Answer A lipid

AnswerB protein

Answer C glycogen

AnswerD lipofuscin

Answer E water

2. Which of the following is a feature of apoptosis?

Answer A Karyolysis

AnswerB Cellular swelling

Answer C Involvement of a large number of cells

AnswerD Chromatin condensation

Answer E Associated inflammatory changes

3. Which of the following is NOT a feature of reversible cell injury?

Answer A Cellular swelling

AnswerB Reduction of ATP synthesis

Answer C Reduced cellular pH

Ans)verD Clumping of nuclear chromatin

Answer E Defects in cell membrane

4. Fatty change:

Answer A Is irreversible

AnswerB Does not impair cellular function

Answer C Is most commonly due to diabetes

AnswerD Is caused by alcohol by an increase in intracellular alpha

glycero phosphate

Answer E Only occurs in the liver

5. Metastatic calcification:

Answer A Is encountered in areas of necrosis.

AnswerB Commonly develops in aging or damaged heart valves.

Answer C Can occur with normal serum levels of calcium.

AnswerD Can be associated with metastatic malignancy.

Answer E Is commonly associated with hypoparathyroidism.

6. Regarding apoptosis, which of the following is FALS E?

Answer A It is the responsible for programmed destruction of cells during

embryogenesis.

AnswerB Occurs in pathologic atrophy in parenchymal organs after duct

destruction.

Answer C Cell death by cytotoxic T cells.

AnswerD Associated with inflammation

Answer E Chromatin condensation and fragmentation are features.

7. With regard to mechanisms of cellular adaptation, which of the following
statements is TRU E?

Answer A Hyperplasia refers to an increase in cell size.

AnswerB TNF always acts as an inhibitor of hyperplasia.

Answer C The myocardium adapts to increased workload by

hypertrophy and hyperplasia.

AnswerD Metaplasia is irreversible.

Answer E Barrett's metaplasia is squamous to columnar epithelium in the

distal oesophagus

8. With regard to acute inflammation which of the following is FALS E?

Answer A P avementing of leukocytes must occur.

Answer B The loss of protein from plasma reduces intravascular osmotic

pressure.

Answer C Transmigration of leukocytes occurs as a result of pseudopod

formation.

AnswerD P -selectin is found in Weibel-palade bodies.

AnswerE Leukocyte diapedesis occurs predominantly in the venules.

9. Which of the following statements about angiogenesis is FALS E?

Answer A PDGF selectively induces hyperplasia of lymphatic tissue

Answer B New vessels bud from pre-existing vessels.

Answer C There is proteolytic degradation of the parent vessel basement

membrane.

AnswerD New vessels are leaky due to incompletely formed

inter-endothelial junctions.

AnswerE VEGF receptors are largely restricted to endothelial cells.

10. In the mononuclear phagocyte system:

Answer A Aggregations of macrophages in the kidney are known as

Kupffer cells.

AnswerB The life span of tissue macrophages is about three days.

Answer C The half-life of blood monocytes is about one month.

Answer D Chemotactic stimuli for monocytes include C5a and certain

growth factors.

AnswerE Monocytes transform into smaller macrophages when they

reach extravascular tissue.

11. In primary wound healing:

Answer A Macrophage infiltration occurs at 24hrs

AnswerB Wound strength is 25% of normal at the end of first week

Answer C Type I collagen is replaced by type III collagen

Answer D Neovascularisation is maximal at day five

AnswerE All of the above

Answers Pathology

1. E

2. D

3. E

4. D

5. D

6. D

7. E

8. A

9. A

10. D

11. D