THE EXCRETION SYSTEM  Two kidneys in the body

DRUGS DEVELOPMENT SINCE 2000  Three sections :

- Renal cortex
1. Renagel (sevelamer hydrochloride); GelTex Pharmaceuticals; - Renal medulla Hydrochlorothiazide
For the reduction of serum phosphorus in patients with end-
stage renal disease (ESRD), Approved July 2000 - Renal pelvis
2000

2. Renagel (sevelamer hydrochloride); Genzyme; For the control

of serum phosphorus in patients with chronic kidney disease
on dialysis, Approved July of 2000 The blood arrives at the kidney via
the renal artery.
 PhosLo; Braintree Laboratories; Oral capsules and Furosemide
gelcaps for the control of hyperphosphatemia in end
2001

stage renal failure, Approved April 2001

 Invanz; Merck; Once-daily injectable treatment for
bacterial infections, Approved November 2001
Arterioles (split from renal artery)
1. Mesnex; Bristol-Myers Squibb, Baxter
Healthcare; Oral tablet to inhibit the
go to the Bowman's Capsules of
nephrons, where the wastes are
2002

hemorrhagic cystitis induced by Ifex

(ifosfamide), Approved March 2002 Spironolactone
taken out of the blood by pressure
1. Oxytrol (oxybutynin transdermal system); Watson filtration.
2003

Pharmaceuticals; For treatment of overactive bladder with

symptoms of urge urinary incontinence, urgency, and
frequency., Approved March 2003
Peritubular capillaries also
1. Cabometyx (cabozantinib); Exelixis; For the surround the nephron so
2016

treatment of advanced renal cell carcinoma,

substances can be taken in and out Acetazolamide
2016

Approved April 2016

2. Lenvima (lenvatinib); Eisai; For the treatment of
advanced renal cell carcinoma, Approved May 2016
of the blood.

1. Jynarque (tolvaptan); Otsuka America; For

The renal pelvis takes urine away
2018

the treatment of autosomal dominant

polycystic kidney disease, Approved April
2018
from the kidney via the ureter.

Both of the ureters lead the urine Mannitol

into urinary bladder, which

expands and sends nerve impulses
when full.

Urine is expelled through the SIDE EFFECTS

urethra and out of the body.  Dry mouth  Muscle pains / cramps
 Thirst  Confusion
 Weakness  Seizures
 Lethargy  Drowsiness
 Restlessness