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Gene*cs
Professor
Rosie
Redfield
The
University
of
Bri*sh
Columbia
2
??
Module
2
Overview
How
DNA
molecules
change
Informa*onal
aspects
Errors
Reading
Copying
Information
Mistake
Correction
Coding Differences
Proofreading
Oops! Recognition
3
??
Module
2
Overview
How
DNA
molecules
change
Muta*on
Rates
2A.
Errors
in
DNA
replica1on
2B.
Why
muta1on
rates
are
so
low
Muta*on
Consequences
2C.
Why
most
muta1ons
are
harmless
2D.
Neutral
muta1ons
in
coding
sequences
2E.
Non-‐neutral
muta1ons
in
coding
sequences
2F.
Muta1ons
in
other
func1onal
sequences
2G.
Other
causes
of
muta1ons
Soma*c
Muta*ons
2H.
Germline
and
soma1c
muta1ons
2I.
Soma1c
muta1ons
??
Module
2
Overview
How
DNA
molecules
change
Avoiding
Muta*ons
2J.
Mutagens
2K.
What
should
we
worry
about?
Evolu*onary
Context
2L.
Muta1ons
and
natural
selec1on
2M.
Gene
evolu1on:
origins
2N.
Gene
evolu1on:
outcomes
2O.
How
DNA
sequences
accumulate
over
1me
2P.
Inferring
evolu1onary
history
from
DNA
differences
?
Coming
up....
Lecture
2A
Muta*on
basics
6