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Extrinsic and intrinsic apoptosis pathwaysApoptosis induction via the death receptor can result
in activation of the extrinsic and intrinsic apoptosis pathways. The role of radiotherapy or
chemotherapy-induced DNA damage on the apoptosis cascade is shown. Interactions of non-
steroidal anti-inflammatory drugs (NSAIDs) with the apoptosis pathways and the effect of
proteasome inhibitors on E6 and E7-mediated degradation of P53 and PRB are shown with
dotted lines. FADD=FAS-associated death domain.