Bleeding Disorders

Definition Methods Normal Value

Bleeding Time Bleeding time is a Duke’s method, Duke method:
laboratory test to assess Ivy’s method and 1-5 min
platelet function and the template method Ivy method: 5-
body’s ability to form a clot 11 min
Template
method: 2-9 min
Capillary Fragility Test This test measures the Hess 0-5 petechiae
ability of the capillaries to Test/Tourniquet
withstand increased stress test
Platelet aggregation test This test measures the - -
ability of platelets to
aggregate in response to
agonist like thrombin
Platelet adhesiveness test This test measures the - The normal
ability of platelets to range is 75% to
adhere to glass surface 95% of platelet
retention
Clotting Time It measures the time taken Lee-white method 4-11 min
for the fresh blood to clot
Prothrombin time Prothrombin time (PT) is Quick’s one stage 11-16 seconds
the time taken for citrated prothrombin time
plasma to clot after the
addition of tissue
thromboplastin and
calcium
Prothrombin This test is performed to - -
Consumption test determine the quantity of
prothrombin remaining in
the serum after clot is
formed
Partial thromboplastin It is a measure of intrinsic - 60-80 seconds
time and common coagulation
pathways
 Activated Partial APTT is the time taken for - 30-40 seconds
thromboplastin time citrated plasma to clot in
the presence of a surface
activator (Kaolin),
phospholipid and calcium
Thrombin Time Thrombin time detects the - 15 to 20 seconds
effectiveness of the final
stage of coagulation in
which fibrinogen is
converted to fibrin
Plasma recalcification A measure of the time - Platelet rich
time taken for clot formation in plasma:100 to
recalcified blood 150 seconds
Platelet poor
plasma:135 to
240 seconds
Clot retraction time It assess the clot stability - Normal clot
and platelet functions retraction
shows more
than 50% of
serum at end of
24 hrs