Bacteria : Acid Fast Bacilli

Nama karakteristik Manifestasi klinis Struktur antigen + enzim + toxin Diagnosis terapi
Mycobacterium Ziehl neelsen  M.Tuberculosis – Primary Mycobacterium tuberculosis tend to be Specimen First line :
red tuberculosis : more resistant to chemical agent (contaminated : HRZES (
Gram  purple  Inhaled  alveoli  peripheral because of the hydrophobic nature of sputum, urine, Izoniasid,
colored Lung tissue (tubercles, necrosis, the cell surface. caseous mass) Rifampisin,
Non motile Caseation)  break (blood flow Lipid Fraction: (sterile : pleural Pyrazinamide,
Capsule (-) and spleen)   Wax A fluid, peritoneal Etambutol,
Spora (-) miliaryTuberculosis  Wax B fluid, LCS) Streptomisin)
Aerobic obligat  Ingestion  mouth & tonsil   Wax C (Serpentine cord  microscope (Ziehl
Intracellular enlarged cervical adenitis virulence) Neelsen) Other /
obligat (M. scrofula  intestine (adenitis  Wax D (Delayed type Culture  LJ second line :
Leprae) esenterium)  peritonitis hypersensitivity) (Lowenstein PAS,
 Direct contact  skin ulcer Jensen media), etionamid,
adenitis of regional lymph node Middlebrook liquid sikloserin,
obligat aerob floroquinolon,
Reactivation tuberculosis : kanamycin
Spreading focus, necrosis caseation Tuberculin test 
from primary infection  lungs : + in healthy human Long time – 6-
Chronic tissue lession with immunity, 9 months
Formation of tubercles sick human minimal
Caseation Combination
Fibrosis Serology : by  to avoid
ELISA, resistance
immunoperoxidase
test

Direct contact to skin, mucosa  Specimen  Dapsone,

multiply in fagosit peripheral microscope (ZN) Rifampisin,
nerve, muscle, bone. Culture  mice Clofazimin
foot palm,
 Bacteria : Acid Fast Bacilli
 LL (Lepromatous Leprosy) armadillo,
(ferocious, low host immunity, fibroblast
lepromin -, facies leonina,
mutilation) Lepromin test
 Borderline (immunologic test)
o BL (Borderline Leprosy)
o BT (Borderline Tuberculoid)
 TT (Tuberculoid Type) (good host
immunity, lepromin +, good
prognosis)