1.

In page 2, paragraf 2 line 4 “ disruption of ECM integrity and pathological matrix

remodelling are critically associated with both the development IA an dbone fragility,
could you explain more about this statement
2. In page 2 paragraf 2 line 9 “ both IA and osteoporosis show female predominance
and this predominant may be atributed to sex hormone” could you explain more
why sex hormone can lead IA
3. Page 7 “both osteoporosis and intracranial aneurisma (IA) are female dominant
disease, could you explain more about this statement
4. In page 7 paragraf 2 line 3 women are more likely to have mutiple aneurysma. Please
more explain
5. In page 6 in discussion right colum paragraf 2 line 5 “ local haemodinamic stress and
a mounting inflamatory response on the vessel wall as well as pathologic ECM
remodeling contributed to the development of IA, could you explain about that
6. Inpage 6 pararagraf 2 line 14 studies have shown that copper deficiency is assosiated
with skeletal integrity, could you please explain about that