Iron Deficiency

Pernicious Anemia Sideroblastic Anemia Aplastic Anemia Hemolytic Anemia Thalasemia

Anemia

Stomach Surgery, Lead Poisoning, Toxin, drugs, Inadequate Inherited disease; Genetic (autosomal
Infection, chronic alcoholism, radiation, virus intake of Fe, G6P [Glucose-6- recessive), decrease
Insufficiency intake drugs (progesterone, (EBV, Hepatitis) decrease Fe Phosphatase] synthesis (alpha globin
antibiotic), zinc absorption, Deficiency (use to chain)
Etiology
overdose, Hemorrhage protect RBC from its
hypothermia, destruction; cell’s
congenital energy);
Hemoglobinopathy
Tingling, Neuropathy Failure to growth, Anemia in general, Koilonichia Jaundice, Anemia in general,
(nerve symptoms) for diarrhea, Low Leuko & (spoon nail), hepatosplenomegaly, slow growth, jaundice
Symptoms vit B12 [folate doesn’t incoordination, Platelet anemia in general gallstone, bone (major thalassemia)
have nerve polyuria, blindness, deformity
symptoms] deafness
Decrease B12 Misplacement of Fe in Forming disorder Insufficiency of Increase destruction Impaired Hemoglobin
absorption because of Hemoglobin; of RBCs Fe intake of RBCs before it life formation, leading to
autoimmune attack Protoporphyrin IX end. abnormal morphology
Pathophysiology the Intrinsic factor defect Normal of RBCs
(parietal cell of the Equation: 120 days/4months
gaster) Protoporphyrin IX +
Fe2+  Heme
Megaloblastic RBCs in (Increased) Serum Bone Marrow (Decreased) Jaundice appearance; Microcytic
microscopic exam; Iron; (Decreased) Aspiration shows Serum Iron; Hepatosplenomegaly; hypochromic; Sickle
Schilling test; Serum Total Iron Binding Bone marrow cells (Increased) Gallstone; Bone cell; Target Cell
vit B12 and Folic Acid Capacity*TIBC*; Iron filled with Serum TIBC; Deformity
Ring appearance in Fat/lipid; Microcytic /
Diagnosis
smear Reticulocyte count normocytic
<2 ; Serum iron, (early)
b12, folate (normal
or slightly
increased)
Vit B12 Intramuscular Iron chelation (Fe Bone Marrow Fe supplement Blood transfusion Blood transfusion
Treatment
(cyanocobalamin) release) transplant
USMLE , anemia by cell’s morphology