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*** Acetylation, glutathione conjugation, glycine 15. The maximum effect achieved by a drug is measure
conjugation, sulfation, methylation of?
6. Which of the following factors determines how long it Ans. Efficacy / another name nya yan! Hahahaha
will take for the drug to reach a steady-state 16. Which of the following is the characteristic of a highly
concentration (CSS) in the blood? protein bound drug?
Ans. Half-life Ans. Rapid renal excretion
7. We administer a highly lipid-soluble drug and monitor 17. Pharmacodynamics involved the study of which of the
its elimination the data indicate that it is transformed to a following?
variety of more polar metabolites by a group of heme
proteins that activate molecular oxygen to a form that is Ans. Physiological effects and mechanism of action of
capable of interacting with organic substrates. Which of drugs ( about drugs to body!)
the following is the most likely enzyme or enzyme system 18. Synthetic metabolism of a drug include the following
involved in the initial metabolism of our test drug? except:
Ans. Cytochrome P450s Ans. Hydrolysis (***kasi ang synthetic phase II)
8. All of the following are general mechanism of drug 19. Biotransformation the drugs is to render them?
permeation.
Ans. More lipid soluble (gagawing lipid soluble for
Ans. Aqueous diffusion, lipid diffusion, endocytosis better absorption)
and special carrier transport
20. In the presence of competitive antagonist is:
Ans. Maximum response can be achieved by 25. Therapeutically undesired but unavoidable
increasing the concentration of agonist. pharmacodynamic effect of a drug in therapuetic dose is
called:
21. What is tachyphylaxis?
Ans. Side effects
Ans. Rapidly developing tolerance to a drug
26. Which of the followingg antihypertensive drugs is
22. The passage of drugs into the petus from the placenta
most likely to increase serum uric acid levels and can
is by?
precipitate attach of gout?
Ans. Active transport
Ans. Hydrochlothiazide
23. Which of the following does not lead to termination of
27. Your patient is a 53 year old man with well controlled
drug actions:
type 2 diabetes and normal renal function. Which drug
Ans. Passive reabsorption from renal tubular would be the most rational first choice for starting his
epithelium. (NOT SURE) antihypertensive therapy?
Ans. Unpredictable, inherent, qualitatively abnormal 28. A hypertensive tachycardic female pt. Has a chronic
reaction of a drug open angle glaucoma which of the following drugs would
be the most rational choice for this patient?
Ans. Timolol