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D
ysfunctional can indicating be accompanied endothelial intraocular by significant keratoplasty. lenses (IOL) corneal
or Secondary aphakia edema
IOL implantation combined with Descemet-stripping endothelial keratoplasty (DSEK) is an option for patients and
surgeons electing to address the problems simulta- neously.1 Various IOL implantation techniques in this setting
have been described. YamaneA described secondary IOL implantation using intrascleral fixation of a sulcus- based
3-piece IOL with haptics modified using high- temperature cautery to create bulbous flanged tips, which was an
update to his previously described technique.2 This method is performed without scleral flaps or sutures, instead
using tunnels created with a thin-walled 30-gauge or standard 27-gauge needle. The benefits of this derive from the
relatively minimal invasiveness. A conjunctival peritomy is not necessary, and the technique can therefore be
performed in eyes in which disturbing the conjunctiva could be detrimental. Because most 3-piece IOL models can
be used in this technique, a standard clear corneal incision (CCI) can be used to accommodate a folding IOL,
minimizing surgically induced astigmatism and corneal denervation.
As originally described, disposable high-temperature cautery is used to melt the haptic tips to create a flange.
This article describes the use of bipolar cautery to create the flanged haptics and shows the stability of the fixated
IOL in the context of a combined procedure with DSEK by delaying the haptic tuck until complete air fill of the
anterior chamber. These modifications are applicable to all variations of the double-needle flanged-haptic and DSEK
techniques.
SURGICAL TECHNIQUE Prior to the procedure, it is recommended that the sur- geon verify that (1) the IOL
haptic can fit snugly into the lumen of a specially made thin-walled 30-gauge or a standard 27-gauge needle, and (2)
if using bipolar cautery, the tip of the planned IOL haptic can be adequately melted to create the flange using a test
IOL (Figure 1). The needles are bent in line with the bevel to a length that is approximately the distance from the
sulcus to the pupil center. Ensuring IOL centration with haptic place- ment exactly 180 degrees apart is
accomplished by marking the geographic center of the cornea and using an axis marker centered on this point to
mark the needle entry points. Corneal markings for DSEK centration are placed as necessary. Two paracenteses are
oriented 90 de- grees from the anticipated main incision site as access for intraocular forceps. Another paracentesis
is made for an
593
Submitted: November 12, 2016 | Final revision submitted: January 3, 2017 | Accepted: January 10, 2017
From OptiCare PC, Waterbury, Connecticut, USA. Corresponding author: Lorenzo J. Cervantes, MD, OptiCare PC, 87
Grandview Avenue, Waterbury, Connecticut 06708, USA. E-mail: lorenzo.cervantes.md@gmail.com.
Q 2017 ASCRS and ESCRS Published by Elsevier Inc.
0886-3350/$ - see frontmatter http://dx.doi.org/10.1016/j.jcrs.2017.04.025
anterior chamber maintainer (ACM). A CCI is made of adequate size to accommodate the IOL and the DSEK graft.
At this time, if needed, an anterior or pars plana vit- rectomy can be performed.
The 3-piece IOL is inserted into the anterior chamber with the trailing haptic external to the incision. The first
needle insertion site is 1.5 to 2.0 mm posterior to the limbus at the left corneal axis marking and passes through
conjunctiva and sclera, creating a beveled intra- scleral tunnel 1.5 to 2.0 mm posterior and parallel to the limbus
tangent. When it enters the sulcus, the needle is directed toward the lead haptic, which is guided into the needle
using an intraocular forceps. With the haptic secure, the needle can be left in the tunnel and a similar procedure can
be performed on the trailing haptic. After the haptics are docked, both needles can be removed and the haptics
externalized. Bipolar forceps cautery powered by a phacoemulsification system is set to its highest power. With the
pedal completely depressed, the closed cautery tips are brought close to the haptic tip, without actual contact, to
create a bulbous flange.
Acetylcholine chloride (Miochol) is used to induce miosis, protecting against posterior migration of the DSEK
graft or air. The haptic tips remain external to the conjunctiva as the DSEK graft is prepared, inserted, and unfolded
using the surgeon’s preferred methods. Af- ter the main incision has been sutured securely, the ACM removed, and
the graft in position, a complete air fill of the anterior chamber is slowly achieved to a high pressure while the
position of the haptic flanges are watched. With a secure IOL, there would be no movement of the haptic tips despite
significant anterior chamber pressure from the gas fill or from massaging any interface fluid (Figure 2). After the
graft has re- mained adherent under air for an appropriate time and the eye has been brought back to physiologic
pressure, the flanged haptics can be tucked into the scleral tunnels. No additional change in the DSEK postoperative
course is necessary.
594
TECHNIQUE: COMBINED DOUBLE-NEEDLE INTRASCLERAL IOL FIXATION AND DSEK
Figure 1. Prior to surgery, verify that (A) the haptic fits securely in the needle and (B) the cautery creates adequate heat to create
the flange. The flange made in this case (C) is funnel-shaped and roughly the diameter of a 27-gauge needle.
Volume 43 Issue 5 May 2017
Video 1 (available at http://jcrsjournal.org) shows the technique used and the modifications described.
DISCUSSION Pseudophakic and aphakic bullous keratopathy are frequent causes of secondary endothelial cell
dysfunc- tion and indications for endothelial keratoplasty. Pa- tients with these conditions often require an IOL
exchange or secondary IOL implantation, performed in stages or simultaneously with DSEK. Combining the
procedures does not appear to have a detrimental effect on the graft or visual outcomes,3 although in 1 study,4 the
rates of cystoid macular edema were higher than when the procedures were performed alone. Without adequate
anterior chamber depth or capsule support for appropriate IOLs, artificial support is neces- sary and has been
accomplished in combination with endothelial keratoplasty in a variety of ways, including iris-sutured, iris-claw,
scleral-sutured, and intrascleral- fixated methods.5–10 The technique presented by Yama- neA allows intrascleral
haptic fixation without the need for conjunctival peritomy, scleral flaps, or an assistant. The technique described in
this report shows that the flange tips can be made with bipolar cautery and that the IOL is stable despite high
intraoperative anterior chamber pressure, allowing the procedure to be com- bined with DSEK.
The minimalistic approach of the double-needle flanged-haptic technique enables scleral fixation of an IOL with
tools that are readily and inexpensively available in many operating room settings. Most 3-piece IOLs can be used
with slight variations in the shape of the resulting flange. The surgeon should test the haptic fit in the needle and the
ability to create the flange on a test IOL prior to surgery. The original technique used a thin-walled 30- gauge needle
and disposable cautery. However, capture of the haptic can be accomplished with a 27-gauge needle and bipolar
cautery can produce enough heat to melt the haptic tip. It should be noted that a thin-tipped jeweler- type forceps
cautery (product number K8-7010, Katena
595 TECHNIQUE: COMBINED DOUBLE-NEEDLE INTRASCLERAL IOL FIXATION AND DSEK
Figure 2. A 27-gauge needle is bent (A) and inserted tangentially (B) approximately 2.0 mm posterior and parallel to the limbus
tangent. Using an intraocular forceps (C), the lead haptic (thin arrow) is engaged by the needle (thick arrow) and a similar
procedure is performed with the trailing haptic. The haptics (asterisks) are externalized (D) where the haptic tips are melted to
create the flanges (E and F). Despite significant anterior chamber pressurization (G) during the air fill and the interface fluid
massage (H), the externalized IOL haptics remain visible and stable. After the allotted time has elapsed and physiologic pressure
achieved, the flanges can be tucked into the sclera (I).
Products, Inc.) was unable to create the flange when it was
carefully watching the position of the externalized
haptics. tested. Thicker-tipped McPherson-type forceps cautery
Scleral tunnels of adequate length prevent rotation
and (product number K8-7020 or K8-7021, Katena Products,
posterior IOL displacement. Inc.) easily melted the
haptics. The actual temperature
In conclusion, the technique in this report shows
that in- of different tips was not recorded, but it was presumed
trascleral fixation of an IOL using the flanged-haptic
dou- that the thinner caliber tipped forceps could not conduct
ble-needle technique can be accomplished with
bipolar enough current to produce adequate heat to melt the
cautery and that the IOL is stable despite high
intraopera- haptic. Intraoperatively, after the DSEK graft has been
tive anterior chamber pressures, allowing the
procedure placed, the anterior chamber air fill should be done slowly,
to be combined with DSEK.
Volume 43 Issue 5 May 2017
596
TECHNIQUE: COMBINED DOUBLE-NEEDLE INTRASCLERAL IOL FIXATION AND DSEK
Volume 43 Issue 5 May 2017
6. V ́elez FM, Mannis MJ, Izquierdo L Jr, S ́anchez JG,
Vel ́asquez LF, Rojas S. WHAT WAS KNOWN Combined IOL fixation and DSEK is an option for patients
Simultaneous surgery for corneal edema and aphakia: DSEK and place- ment of a retropupillary iris claw lens. Cornea 2014;
33:197–200 7. Narang P, Agarwal A, Dua HS, Kumar DA, Jacob S, Agarwal A. Glued intra- with poor capsule support and
endothelial dysfunction.
scleral fixation of intraocular lens with pupilloplasty and
pre-Descemet The double-needle flanged-haptic technique of intrascleral
endothelial keratoplasty: a triple procedure. Cornea 2015;
34:1627–1631 fixation of an IOL described by Yamane can be performed without conjunctival peritomy, scleral flaps, or an
assistant.
8. Sinha R, Shekhar H, Sharma N, Tandon R, Titiyal JS, Vajpayee RB. Intra- scleral fibrin glue intraocular lens fixation
combined with Descemet- stripping automated endothelial keratoplasty or penetrating keratoplasty. WHAT THIS PAPER ADDS
J Cataract Refract Surg 2012; 38:1240–1245 9. Prakash G, Agarwal A, Jacob S, Kumar DA, Chaudhary P, Agarwal A. The
double-needle flanged-haptic technique is an option
Femtosecond-assisted Descemet stripping automated
endothelial kerato- that can be combined with DSEK.
plasty with fibrin glue-assisted sutureless posterior
chamber lens implanta- Haptic flanges can be made using bipolar cautery. The IOL position can be verified during the anterior
chamber air fill by delaying scleral tuck of the haptics until the graft has been secured.
tion. Cornea 2010; 29:1315–1319 10. Karimian F, Sadoughi M-M. Air-assisted Descemet stripping automated endothelial
keratoplasty with posterior chamber fixation of an aphakic iris- claw lens. J Ophthalmic Vis Res 2010; 5:205–210. Available at:
https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC3379922/pdf/jovr-5-3-218-779- 1-pb.pdf. Accessed March 10, 2017
OTHER CITED MATERIAL A. Yamane S, “Transconjunctival Intrascleral IOL Fixation With Double-Needle REFERENCES
1. Wylęgała E, Tarnawska D. Management of pseudophakic bullous ker- atopathy by combined Descemet-stripping endothelial
keratoplasty and intraocular lens exchange. J Cataract Refract Surg 2008; 34:1708–1714 2. Yamane S, Inoue M, Arakawa A,
Kadonosono K. Sutureless 27-gauge nee-
Technique,” film presented at the ASCRS Symposium on Cataract, IOL and Refractive Surgery, New Orleans, Louisiana, USA,
May 2016, and the 29th annual meeting of the Asia-Pacific Association of Cataract & Refrac- tive Surgeons, Bali, Indonesia,
July 2016. Available at: http://ascrs2016. conferencefilms.com/atables.wcs?entryidZ0082&bpZ1. Accessed March 10, 2017
dle–guided intrascleral intraocular lens implantation with lamellar scleral dissection. Ophthalmology 2014; 121:61–66. Available
at: http://www. aaojournal.org/article/S0161-6420(13)00803-8/pdf. Accessed March 10, 2017
Disclosure:
The author has no financial or proprietary interest in any material or method mentioned. 3. Shah AK, Terry MA,
Shamie N, Chen ES, Phillips PM, Hoar KL, Friend DJ, Davis-Boozer D. Complications and clinical outcomes of Descemet strip-
ping automated endothelial keratoplasty with intraocular lens exchange. Am J Ophthalmol 2010; 149:390–397 4. Yazu H,
Yamaguchi T, Dogru M, Ishii N, Satake Y, Shimazaki J. Descemet- stripping automated endothelial keratoplasty in eyes with
transscleral- sutured intraocular lenses. J Cataract Refract Surg 2016; 42:846–854 5. Cagini C, Fiore T, Leontiadis A, Biondi L,
Leaci R, Delfini E, Macaluso C. Simultaneous Descemet stripping automated endothelial keratoplasty and aphakic iris-fixated
intraocular lens implantation: a case series. Cornea 2011; 30:1167–1169
First author: Lorenzo J. Cervantes, MD
OptiCare PC, Waterbury, Connecticut, USA