WHO CLINICAL STAGING

WHO Clinical Stage I WHO Clinical Stage III WHO Clinical Stage IV1
FOR CHILDREN FOR CHILDREN FOR CHILDREN

 Asymptomatic  Moderate unexplained malnutrition not
 Persistent Generalised lymphadenopathy responding to standard therapy
 Unexplained persistent diarrhea for longer than
14 days
WHO Clinical Stage II  Unexplained persistent fever above 37.5
(intermittent or constant for more than one
FOR CHILDREN month)
 Persistent oral candida (outside the first 6-8
 Unexplained persistent hepatomegaly and weeks of life)
splenomegaly  Oral hairy leukoplakia
 Papular itchy skin eruptions  Acute necrotizing ulcerative gingivitis or
 Extensive skin warts periodontitis
 Extensive molluscum contagiosum  TB lymphadenopathy
 Recurrent oral ulcerations  Pulmonary tuberculosis
 Unexplained persistent parotid gland  Severe recurrent presumed bacterial pneumonia
enlargement (2 or more episodes in a 6mo period)
 Linear gingival erythema  Symptomatic lymphoid interstitial pneumonitis
 Herpes zoster (LIP)
 Recurrent or chronic respiratory tract infections  Chronic HIV-associated lung disease, including
(sinusitis, otorrhoea, tonsillitis, otitis media) bronchiectasis
 Fungal nail infections  Unexplained anaemia (<8g/dl), neutropaenia
(<500/mm3) or thrombocytopenia
(<50,000/mm3)
 Unexplained severe wasting, stunting, or severe
malnutrition not responding to treatment
 Pneumocystis carinii (jeroveci) pneumonia
 Recurrent severe presumed bacterial infections
(eg. Empyema, pyomyositis, bone or joint
infections, meningitis, sepsis, but excluding
pneumonia)
 Toxoplasmosis of the brain
 Cryptosporidiosis with diarrhea>1 month
 Isosporiasis with diarrhea > 1 month
 Cryptococcosis, extrapulmonary
 Cytomegalovirus of an organ other than liver,
spleen or lymph node
 Chronic herpes simplex infection (orolabial or
cutaneious for > 1 month)
 Progressive multifocal leukoencephalopathy
 Any disseminated endemic mycosis
 Candidiasis of oesophagus, trachea and bronchus
 Atypical mycobacteriosis, disseminated or lungs
 Extrapulmonary tuberculosis excluding TB
lymphadenopathy
 Lymphoma (cerebral or B cell non-Hodgkin)
 Kaposi’s sarcoma
 HIV encephalopathy
 HIV-associated cardiomyopathy or HIV-associated
nephropathy

1
Some additional specific conditions can also be included in regional classifications (such as reactivation of American trypanosomiasis [meningoencephalitis and/or
myocarditis] in the WHO Region of the Americas, disseminated penicilliosis in Asia and HIV-associated rectovaginal fistula in Africa).