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This document contains forward-looking statements, which can be identified by terminology such as ‘expect’,
‘would’, ‘will’, ‘potential’, ‘plans’, ‘prospects’, ‘estimated’, ‘aiming’, ‘on track’ and similar expressions. Such
statements may be subject to risks and uncertainties that could cause the actual results to differ materially from
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update forward-looking statements to reflect actual results, changed assumptions or other factors. This document
does not constitute, or form part of, any offer or invitation to sell or issue, or any solicitation of any offer, to
purchase or subscribe for any ordinary shares in Syngenta AG, or Syngenta ADSs, nor shall it form the basis of, or
be relied on in connection with, any contract there for.
Our claims today

Continued grower demand for innovation: long term

scope for value creation through technology

Syngenta R&D is the most innovative and

productive in the industry

Rate of innovation accelerating and

productivity improving

R&D as percent of sales expected ~9%

Leverage opportunity at three levels: platforms,

technologies, crops

3
Continuing grower demand
for innovation

Current needs Future needs

Yield
~$300bn
Biotic stress
– Weeds, insects, disease
~$600bn
– Resistance management
– Regulatory changes

Abiotic stress
– Climate change
– Constrained natural resources
– Change in input factors
Major pest shifts

~$900bn
Estimated total
economic value
Source: Syngenta estimates

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Biotic stress and resistance
management
2014 estimated area Glyphosate resistance Global lepidoptera Insect resistance
affected by glyphosate increasing (chewing pest) market in Brazil
resistance
Up 20% year on year
to ~1/3 of total US 21 >$2bn – Bt resistance results in
tripling of lep control market
crop area resistant weeds market value – Viptera the only trait to
globally control Fall armyworm

Mha $m

58%
40
35
78
30
25 US farmers Sucking
20
15
affected in 2014 88
Chewing
122
10
5 33
0 Pluesia Helicoverpa
2013 2014
Brazil Argentina USA Spodoptera Other

Source: Company information, Phillips McDougall

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Regulatory change: Syngenta capability
creates competitive advantage
Time and cost of innovation increasing Some key products no longer available to growers
– Additional study requirements Example: neonicotinoid seed treatment
– Protracted regulatory approval timelines
– Application of cut-off criteria

4:1
EU product withdrawals
outpacing new product
introductions
Cabbage stem flea beetle damage in oilseed rape in UK and Germany due to
suspension of neonicotinoid seed treatments

6
Yield improvement remains
an imperative

Rolling 10 World Agricultural “Up to 25 percent of the world’s food

year average population land use production may be lost by 2050 due to
climate change, land degradation,
growth in cropland losses, water scarcity and
crop yields Billions of people Billion hectares
infestations.”
Achim Steiner
UN Under-Secretary General and UNEP Executive
4.9 3.3 Director at the GFFA
4.0% 8

3.0% 6
3.0
Potential area
Total planted area for agricultural
2.0% 4 ~1.6 billion ha expansion

0.3 0.14
1.0% 2
1.2
0.3
0.0% 0
1970 1980 1990 2000 2010 Agricultural Permanent Permanent Major 0.3
Undefined
land meadows crops crops

Source: USDA (corn, soybean, rice, wheat), FAO Sources: FAO, World Bank, WWF
Syngenta analysis

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Innovation lifecycle

Chemistry Revenue
Breeding GM Traits
Time
Cost

• 20 leads in early Research 8 major crops • 12 leads with late Research

• 5 leads in late Research potential*
• 4 leads in Development >500 launches per year • 10 leads in late Research
• We maintain and register • We maintain and register
60 AIs¹ 8 traits
Varieties replaced every
• ~ 600 projects currently 3.5 years³ • Introgressed into 3 crops
in PLCM²
• ~ 80 years of experience • ~ 20 years of experience

¹Active ingredient ²Product Life Cycle Management ³Average time in market is 3.5 years. * In next 12 months
50% don’t make it past 2 years – those
8 that do succeed last for many years.
Evolution of R&D spend by capability

– Sustained investment in chemistry R&D investment $m

– Registration of full GM trait portfolio
– Global development platform in Seeds 1600
New Technology
– Investment in new capabilities 1400

1200

1000
CAGR 2001-2014
800
R&D Breeding
600
+5% +7%
400
GM Traits Chemistry
200
+8% +3% 0
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
% of sales 11.4% 11.2% 11.1% 11.1% 10.1% 10.5% 9.6% 8.9% 9.3% 9.4% 9.0% 8.9% 9.4% 9.4%

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Syngenta R&D is the most
productive in the industry
Cumulated Cumulated R&D Sales/R&D
Sales $bn expenses $bn
2005-2014 2005–2014

117 11.0 10.7

– Period of investment in
51 4.8 10.5 Seeds platform

95 9.7 9.8 – Early investment in new

technologies

113 11.8 9.6

– Sustained returns on Crop
Protection R&D
80 8.3 9.6

54 7.0 7.7

Source: Phillips McDougall, Syngenta estimates

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New launches and lifecycle
management bring share gain
2008–2014 Crop Protection market share 2005 2014

Average 1 new AI per year

18% 20%
Focus on blockbuster opportunities

18% 18%

Formulation 13% 13%

and lifecycle
management
excellence 9% 10%

9% 9%

~600 7% 7%

New product launches per year*

Others 26% 23%

* Launch defined as new Syngenta products (incl. formulations) marketed in specific countries Source: Phillips McDougall. Excluding professional products
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Seeds: leading innovator
in trait technology
Corn trait revenue and royalty
income – cash basis
$m Traits Complete independent corn
1'000
2.5X trait platform
900
800
700 Comprehensive insect control
600 including Refuge In a Bag
500
400
MIR604: Pioneer enabled for
300 Access to market dual CRW control in USA
200
100 Access independent seed
- companies MIR162 licensed to Monsanto,
2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
DuPont Pioneer, Dow: most
SYT Brands GLG licensees Direct licensees
Direct licensing to efficacious broad lep trait,
other majors
leading in Fall armyworm
Revenue stream to double in next 5 years following control in Brazil
China approval of MIR162 Branded business enablement

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Crop Protection:
R&D productivity increasing

Post merger Building SYT pipeline Globalization of R&D

Period 2000–2004 2005–2009 2010–2014

Total # of launches 4 3 4 Productivity

Annual peak sales $bn 1.0 1.6 2.0

Average sales per launch $bn 0.2 0.5 0.5 Effectiveness

Higher sales per launch than competitors

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Rate of innovation accelerating

Enhancing R&D Productivity

Period 2015-2020 2021–2022

Total # of launches 4 6 Productivity

Annual peak sales $bn 1.8 2.5

Average sales per launch $bn 0.5 0.4 Effectiveness

Innovation across all product lines

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Innovation overview

Fungicides
Seguris Elatus Orondis Lead 3
Adepidyn

Insecticides
Lead 4 Lead 1

>$500m
Herbicides
Lead 2
Acuron
>$200m

Seedcare
Lead 5 Lead 7 >$100m
Vibrance Fortenza Clariva Lead 6

Peak sales
Year of launch 2012 2017 2022
potential

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ADEPIDYNTM:
the next SDHI blockbuster
1. Sales by Region 2. Sales by Crop at peak – Time to peak sales often
Peak sales 3-5 years
$m
>$750 m – Chemistry design ensures
750 Vegetables Cereals
full registrability across
500 regions
Specialty >$750m
Corn
250 – Focus on Fusarium: broad
DFC crop applicability
-0 Soybean
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025
– Low cost to manufacture
North America Latin America EAME APAC
with COGS optimization
5 years from launch
3. Economies of scale in COGS 4. Free cash flow contribution – Free cash flow break even
AI Volume AI COGS $m 3 years from registration
‘000 kg $/kg 300

200
2'000 NPV @ 8%
100
~$1.2 bn
1'000
0

0 -100
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025

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Track record of delivering GM traits

Post merger Building SYT pipeline Globalization of R&D

Period 2000–2004 2005–2009 2010–2014

Total # of launches 1 3 5 Productivity

Annual peak sales $bn 0.1 0.4 0.9

Average sales per launch $bn 0.1 0.1 0.2 Effectiveness

– Rich early GM pipeline – Enhanced trait development – Leadership in above and below
with no route to market capabilities: successful launches ground insect control
of proprietary traits – Multiple modes of action to
manage insect resistance

Industry faces lower rate of innovation over the next decade

Focus on upgrades, stacks

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Rich early pipeline and strong
biotechnology platform
Next CRW (corn rootworm)
– Attractive market driven by
resistance to existing MoAs

Relative probability
Next CRW
Next broad lep Replacement Traits
– Driven by resistance (Brazil, Southern US) for Insect Control

New HT (herbicide tolerance) New HT Abiotic Traits

Next broad lep
– New resistance-breaking herbicides
– Value in combined trait and chemistry sales
Soybean rust Corn drought
Carb yield
– Convenience and resistance management
Sucking insect New Traits Soybean Sucking
rust
insects
– No trait yet for this type of pest
Drought or yield
– Abiotic traits: new area of opportunity 10 15 20
Years

Replacement Traits New Traits

Bubbles represent relative sales potential
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More than 20 Corn trait leads in research:
10 already in late research
Target
Insect control (Lepidoptera)
Insect control (Corn rootworm)
Water optimization
Yield
* In next 12 months
19
Research leads
3x in late research
3x with late research potential*
2x in late research
1x with late research potential*
5x in late research
6x with late research potential*
2x with late research potential*
High level description
– Current research leads cover wide spectrum of economically
important Lepidopteran pests
– Potential new modes of action based on activity against Cry1F
resistant fall armyworm biotypes
– Non-Bt protein and RNAi insect control leads
– Potential new modes of action based on activity against Cry3
resistant western corn rootworm colonies
– Several leads for manipulation of ABA pathway
– Multiple drought tolerance genes
– Members of gene families associated with increases in seed
number and grain weight
Hybrid wheat: game-changing non-GM technology
with peak sales potential >$3bn

Wheat area opportunity (in Mha) Hybrid wheat launch plan Strongest germplasm in
$bn the industry, leading
expertise
3
US
France,
US
India Canada
UK, Poland,
Germany Germany
CIS Technical proof of
concept achieved in 2014
2

Yield performance of
1 hybrids

0 2019 2020 2021 2022 2023 2024 2025 Robustness of sterility

2020 2022 2024 2026 2028 2030 2032
system

Total area for Addressable area Syngenta hybrid

hybrid wheat = for Syngenta sales Seed production
220Mha hybrids
capability

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Leverage in R&D: platforms enable flexible
use of expertise and resources

1. 2. 3.
Portfolio Product safety & Biological
platforms regulatory assessment
Combine CP and Seeds Early decision making Site consolidation:
Biological assessment sites
portfolio teams to reduce late development ~$40m cost saving 100%
20% reduction in employees attrition
Genotyping: 90%

Outsourcing cost per data point reduced 80%

70%
>50% of re-registration by one third Multi-crop
60%
activities sites
Winter nurseries 50% Single crop
Product safety cost moved to low cost locations 40% sites

33% below industry average 30%

20%
10%
0%
2012 2017

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Leveraging technology in genetics,
chemistry and computational science
Using our deep understanding of mode Existing chemistry New design
of action to drive innovation
Genetics + +
– We actively monitor for the first Fails in the resistant weed Activity against target restored
signs of evolution of herbicide
resistance in weeds
– We understand in detail how the
shape of the target has
changed in the resistant plant

Chemistry
– Making the herbicide fit again
– Resistance breaking chemistry
by design

Computational science

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Leveraging our breadth and global
crop presence

Crops Rice Corn Capabilities

Global breeding managed as Barley – Technical platforms
a function with methodology Wheat leveraged to other crops:
and technology approaches genomics, molecular marker
(e.g. native trait) developed analysis, precision trialing
principally for corn and Hybrid seed
applied in broader production – Yield heterosis: genotype x
geographies and crops Seeds Product genotype interaction
Development Vegetables Grain quality – Germplasm adaptation to
Fruit quality and environment for yield stability
uniformity – Discovery and development
Sunflower Yield heterosis
of native genetics for pest &
WOSR
pathogen resistance
Pest and
pathogen Soybean Yield stability:
resistance abiotic stress
Yield potential tolerance

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Our claims today

Continued grower demand for innovation: long term

scope for value creation through technology

Syngenta R&D is the most innovative and

productive in the industry

Rate of innovation accelerating and

productivity improving

R&D as percent of sales expected ~9%

Leverage opportunity at three levels: platforms,

technologies, crops

24
New crop protection pipeline
Peak sales >$3.6bn
New blockbusters in large markets
Product Indication Crops Status Launch year Peak sales
ADEPIDYN™/pydiflumetofen Fungicide Cereals, corn, soybean, specialty vegetables Stage 3 2016 >$750m

Lead 1 Insecticide Multiple crops Stage 2 2021 >$550m

Lead 2 Herbicide Corn Stage 1 (late) 2022 >$600m

Lead 3 Fungicide Cereals, soybean Stage 1 (late) 2022 >$600m

Large products in smaller segments

Product Indication Crops Status Launch year Peak sales
Fungicide Vegetables, specialty Stage 3 2016 >$150m

Lead 4 Insecticide Vegetables, specialty Stage 3 2020 >$250m

Lead 5 Seedcare Cereals, corn, soybean Stage 1 (late) 2021 >$400m

Lead 6 Seedcare Multiple crops Stage 1 (late) 2022 >$200m

Lead 7 Seedcare Multiple crops Stage 1 (late) 2022 >$100m

Stage 1 = invention, optimization Stage 2 = evaluation Stage 3 = development and launch

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Four waves of innovation
in seeds and traits

New phase of GM trait

innovation
New phase of GM trait
Scaling seed innovation – Abiotic stress
Corn trait revenue and production capability – Replacement traits – Carb yield
royalty income Hybrid wheat launches for insect control
Further HYVIDO in 3 regions – New insect traits
expansion – Disease control
Native traits
development

2015-2020 2020-2025 2025-2030 2030-2035

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