MEDICATION CLASSIFICATION ACTION INDICATION CONTRAINDICATION ADVERSE EFFECT DRUG-TO-DRUG NURSING

(GENERIC & INTERACTION CONSIDERATIONS

BRAND)

Tramadol Therapeutic: Binds to mu- Moderate to Contraindicated in: CNS: Seizures, Drug-to-drug: Assess type,
Analgesics opioid moderately Hypersensitivity, dizziness, anxiety, Increase risk of location, intensity
-Conzip (centrally acting) receptors. severe pain. cross-sensitivity with CNS stimulation, CNS depression of pain before and
-Ultram Inhibits opioids may occur: confusion, when used 2-3 hrs (peak) after
reuptake of Patients who are coordination concurrently with administration.
serotonin and acutely intoxicated other CNS
norepinephrin with alcohol, EENT: visual depressant, Assess BP and
e in the CNS. sedatives/hypnotics, disturbances including alcohol, respiratory rate
centrally acting antihistamines, before and
analgesics, opioid CV: Vasodilation sedative/hypnotic periodically during
analgesics or s administration.
psychotropic agents. GI: Constipation,
abdominal pain, Increase risk of Assess bowel
nausea, anorexia seizures with high function routinely.
doses of
GU: Menopausal penicillin,
symptoms, urinary cephalosporin,
retention/frequenc phenothiazine
y
 MEDICATION CLASSIFICATION ACTION INDICATION CONTRAINDICATION ADVERSE EFFECT DRUG-TO-DRUG NURSING
(GENERIC & INTERACTION CONSIDERATIONS
BRAND)

Cefuroxime Therapeutic: anti- Binds to Treatment of: Contraindicated in: CNS: Seizures (high Probenecid Assess for infection
infective bacterial cell Respiratory Hypersensitivity to dose) decreases excretion (vital signs:
-Ceftin wall membrane, tract infection, cephalosporin, serious and increases blood appearance of
- Zinacef Pharmacologic: causing cell skin and skin hypersensitivity in GI: levels. wound, sputum,
Second-generation death. structure penicillin. Pseudomembranous Aminoglycosides urine, and stool;
cephalosporin. infections, colitis, diarrhea, and loop diuretics WBC) at beginning of
bone and joint nausea, vomiting, may increase the and throughout
infection (IV), muscle cramps. risk of therapy.
urinary tract nephrotoxicity.
infection, DERM: rashes, Observe patient for
gynecological urticaria. signs and symptoms
infection, of anaphylaxis (rash,
septicemia LOCAL: pain at IM pruritus, wheezing).
(IV), site, phlebitis at IV Discontinue the drug
Meningitis, site. and notify health
perioperative care professional
prophylaxis. immediately if these
symptoms occur.

IV: Changes site

every 48-72 hr to
prevent phlebitis.

DIRECT IV:
Reconstitute vial
with sterile water for
injection.
 MEDICATION CLASSIFICATION ACTION INDICATION CONTRAINDICATION ADVERSE EFFECT DRUG-TO-DRUG NURSING
(GENERIC & INTERACTION CONSIDERATIONS
BRAND)

Ketorolac Therapeutic: Inhibits Short-term Contraindicate in: CNS: stroke, Increase level and Assess for rash
nonsteroidal anti- prostaglandin management hypersensitivity, Cross- euphoria, headache. the risk of adverse periodically during
- Sprix inflammatory synthesis, of pain. sensitivity with other reaction: therapy.
- Toradol agent, nonopioid producing NSAIDs may exist EENS: increase concurrent use in
analgesic peripherally lacrimation, nasal contraindicated. Pain: Assess pain
rd
mediated OB: Chronic use in 3 discomfort (note type, location,
analgesia. Also trimester may cause Increase risk of and intensity) prior
has antipyretic constriction of ductus RESP: asthma, bleeding when to 1-2 hrs following
and anti- arteriosus, may inhibit dyspnea used in administration.
inflammatory labor and increase phentoxifylline;
properties. maternal bleeding at CV: Myocardial concurrent use in Direct IV: Administer
delivery. infarction, edema, contraindicated. undiluted.
pallor Concentration: 15-30
PEDI: Safety not mg/ml. Rate:
establish in neonates. GU: Oliguria, Renal administer over at
toxicity, urinary least 15 sec.
frequency
Advice patient to
HEMAT: Prolonged consult health care
bleeding time. professional if rash,
itching, visual
disturbances, and
tinnitus occurs.
 MEDICATION CLASSIFICATION ACTION INDICATION CONTRAINDICATION ADVERSE EFFECT DRUG-TO-DRUG NURSING
(GENERIC & INTERACTION CONSIDERATIONS
BRAND)

Methylergonovin Therapeutic: Directly Prevention OB: Should not be used CNS: stroke, Excessive Monitor BP, heart
e Oxytocic stimulates and treatment to induce labor; dizziness, headache. vasoconstriction rate, and uterine
uterine and of postpartum may result when response frequently
-Mehergine Pharmacologic: vascular smooth or post LACTATION: Do not EENT: tinnitus. used with heavy during medication
Ergot alkaloids muscle. abortion breastfeed during cigarette smoking, administration.
hemorrhage treatment and for 12 hrs RESP: Dyspnea. other vasopressors, Notify health care
caused by after the last dose. such as dopamine, professional
uterine atony CV: hypertension, or beta-blockers. promptly if uterine
or USE CAUTIOUSLY IN: arrhythmia, AV relaxation becomes
subinvolution. Hypertensive or Block, chest pain, prolonged or if
eclamptic patient; palpitations. character of vaginal
history of or risk factors bleeding changes.
for coronary artery GI: nausea, vomiting.
disease. Assess for signs of
GU: crams. ergotism
EXERCISE EXTREME
CAUTION IN:OB: Third DERM: diaphoresis. Advise patient that
stage of labor medication may
MISC: allergic cause menstrual-like-
reaction. cramps.

Caution patient to
avoid smoking,
because nicotine
constrict blood
vessels.
 MEDICATION CLASSIFICATION ACTION INDICATION CONTRAINDICATION ADVERSE EFFECT DRUG-TO-DRUG NURSING
(GENERIC & INTERACTION CONSIDERATIONS
BRAND)

Ranitidine Therapeutic: Inhibits the Short-term Hypersensitivity; syrup CNS: Confusion, May increase the Assess patient for
Antiulcer agents action of treatment of contains alcohol and dizziness, effects of epigastric or
-Zantac histamine at active should be avoided in drowsiness, warfarin. May abdominal pain and
Pharmacologic: the h2- duodenal patients with known hallucinations, decrease frank or occult
Histamine h2 receptor site ulcers and intolerance. headache. absorption of blood in the stool,
antagonist. located benign ketoconazole, emesis, or gastric
primarily in gastric USE CAUTIOUSLY IN: CV: arrhythmias. geftinib. aspirate.
gastric parietal ulcers. OB: pregnancy
cells, resulting Maintenance LACTATION: Passes GI: Constipation, Advise patient to
in inhibition of therapy for into breast milk and diarrhea, nausea. report onset of
gastric acid duodenal can cause decrease black, tarry stools:
secretion. and gastric stomach acid in the GU: decrease fever, sore throat;
ulcers after infant. sperm count, diarrhea to health
healing of erectile care professional
active ulcer. dysfunction. promptly.

IV: ENDO:
prevention gynecomastia.
and
treatment of
stress-
induced
upper GI
bleeding in
critically ill
patient.