SHOCK, Vol. 27, No. 1, pp.
108Y109, 2007
Book Reviews
David J. Dries, Book Review Editor
PHARMACOGENOMICS AND PROTEOMICS:
ENABLING THE PRACTICE OF PERSONALIZED
MEDICINE AMERICAN
Editors: Steven H.Y. Wong, PhD, Mark W. Linder, PhD;
Roland Valdes Jr., PhD
Bibliographic Data: Association for Clinical Chemistry, Inc.,
2006. ISBN: 1-59425-046-4, 409 pages, soft cover, $135.00.
Reviewer’s Expert Opinion:
Description: This is a current snapshot of the rapidly
evolving field and clinical applications of pharmacogenom-
ics and proteomics. Purpose: The purpose of this book is to
provide a compendium of current information about the
applications of pharmacogenetics and proteomics and their
role in personalized medicine. This is a worthy objective,
given the rapid evolution of this field and need for a reference
compilation of this information. The authors have successfully
achieved their purpose. Audience: This book is written at a
fairly high level and will appeal most to those actually
working in the areas of genomics, pharmacogenetics, or
proteomicsVpracticing clinical laboratory scientists, patholo-
gists, pathology and laboratory medicine residents, fellows,
pharmacists, research laboratories, manufacturers developing
or marketing assays, and regulators involved in reviewing such
assays for approval. The authors are credible authorities in their
fields. Features: This full-sized paperback book contains a
wealth of information about the rapidly evolving fields of
pharmacogenomics and proteomics. The book is written at a
fairly sophisticated level, most appropriate for those working
directly in this area (beginners will undoubtedly find it
interesting but will have considerable genomics jargon to
master). The book is divided into four major sections: an
introductory and background section, methodologies and
techniques, selected clinical applications, and emerging
biotechnologies. I am not current in this area and find this
book absolutely fascinating and the right one to bring me
up to speed. Although I fully expect pharmacogenomics
to revolutionize how we choose which drug to prescribe
to which patient, I have never thought that pharmacoge-
nomics can also help solve unexplained deaths (i.e., forensic
pharmacogenomics)Ywow! There were many more applica-
tions than those with which I was familiar, so this book was
a real eye opener. The major missing piece was discussion
about standardization of this testing across multiple labo-
ratories and manufacturer platforms. How can the consumer
be assured that a result from one laboratory will be reliably
obtained by another? This is a topic of significant con-
troversy today among the international community, and it
will be interesting to have a discussion of these issues.
108
Copyright @ 2006 by the Shock Society. Unauthorized reproduction of this article is prohibited.
Assessment: This is a great book that presents, in a single
place, a nice assortment of articles and topics representative of
the rapidly evolving field of pharmacogenomics and proteo-
mics. This is a great book if you want to update your
knowledge in this area.
Reviewer: Valerie L. Ng, PhD, MD (Alameda County
Medical Center/Highland Hospital)
PEDIATRIC CRITICAL CARE MEDICINE
Editors: Anthony D. Slonim, MD, DrPH, FCCM, Murray M.
Pollack, MD, MBA, FCCM
Bibliographic Data: Lippincott Williams & Wilkins, 2006.
ISBN: 0-7817-9469-2, 936 pages, hard cover, $159.00.
Reviewer’s Expert Opinion:
Description: This is a multiauthored, comprehensive textbook
of pediatric critical care. Purpose: Provided is a background of
physiology followed by clinical application in critical care
management of the child. Audience: Trainees and senior
practitioners in pediatric critical care medicine will find this
book useful. Although many of the senior contributors are from
the Children’s National Medical Center in Washington, DC,
contributors represent major pediatric centers in North America
and Europe. Features: This attractive book is divided into two
broad sections. The first section reviews pathophysiology
beginning with cellular biology, immunology, and inflamma-
tion, with applications in infectious disease, pediatric cardiol-
ogy, and respiratory support. The final 400 pages comprise
approximately 55 chapters organized by organ system. Equal
weight is given to sections on cardiac, respiratory, endocrine,
immunologic, neurologic, renal, and gastrointestinal disorders.
Chapters are clearly written, and tables and black-and-white
line drawings are reproduced with excellent quality. Repro-
duction of radiographs is less consistent, and all photographs
are black and white, which compromises the presentation of
infectious syndromes. Each chapter contains a reference list
with most citations coming from primary work in the adult and
pediatric literature. However, some chapters give great empha-
sis to textbooks and include few journal citations. The table of
contents divides chapters by content type and provides author-
ship, whereas the extensive subject index includes separate
citations for figures. An appendix includes several pages of
conversions, formulas for calculations, and tables of critical
drug doses. Assessment: This is a superb reference for the
reader needing a review of basic pathophysiology and clinical
SHOCK JANUARY 2007
applications in the management of the child in the intensive
care unit. A particular strength is the review of pathophysiology
and general treatment principles in the early chapters. Coverage
of injury in children, a significant health care concern, is
inconsistent at best.
Reviewer: David J. Dries, MD (University of Minnesota
Medical School)
ATLAS OF HUMAN ANATOMY, 4TH EDITION
Author: Frank H. Netter, MD
Bibliographic Data: Elsevier, 2006. Imprint: Saunders.
ISBN: 1-4160-3699-7,596 pages, hard cover, $125.00.
Reviewer’s Expert Opinion:
Description: This is one of the best human anatomy atlases I
have used. It is accurate and uses high-quality drawings in its
extensive coverage of human anatomy. I have been using the
previous edition (3rd edition, 2003) in my teaching of a
medical human anatomy class. Purpose: The purpose is to
provide a learning resource to students, residents, and faculty
in the health sciences and related professions. With such
superb quality, the book has certainly met the objective.
Audience: According to the author, the book is written for
students, residents, faculty, and practitioners in medicine and
surgery. The book is particularly useful for medical students
in their human anatomy class. The book is also very useful for
anatomy instructors as a teaching aid or a reference. Dr.
Netter and his successors are well known in the field of
human anatomy illustration. Features: Several unique features
distinguish this edition. New clinically related images in
drawings, computed tomography, x-ray, and magnetic reso-
nance images make it easier to connect anatomy to clinical
application. The trunk region cross sections have moved from
the back of the book to the appropriate chapters, making it
easier to connect anatomy dissection with magnetic resonance
imaging. The labeling on figures is very detailed, making it
valuable not only for students learning anatomy, but also for
professionals as a reference. The CD-ROM is extremely
useful for instructors. Assessment: This is one of the best
anatomy atlases. It is very useful for medical school teaching.
The superb drawings are simple but accurate, clear but detailed.
The addition of clinical content makes this new edition
valuable.
Reviewer: Ming Xiaoming Zhang, PhD (University of Kansas
Medical Center, Kansas City)
Copyright @ 2006 by the Shock Society. Unauthorized reproduction of this article is prohibited.
109
DIAGNOSTIC AND SURGICAL IMAGING ANATOMY:
BRAIN, HEAD, NECK, AND SPINE
Authors: H. Ric Harnsberger, MD Anne G. Osborn, MD,
FACR Andre J. Macdonald, MBChB, Jeffrey S. Ross, MD,
Kevin R. Moore, MD Karen L. Salzman, MD
Bibliographic Data: Lippincott Williams & Wilkins, 2006.
ISBN: 1-931884-29-3, 800 pages, hard cover, $249.00.
Reviewer’s Expert Opinion:
Description: This is an all encompassing neuroimaging atlas.
With great detail and precision, it explores the complex anatomy
of the brain, spine, head, and neck. Purpose: According to the
author, the purpose is to provide physicians with a neuro-
anatomy atlas that will improve both the accuracy and
efficiency of image interpretation. Given the complexity of
this subject, the objectives are worthy, and the book is much
needed. The authors meet their goals and in many ways exceed
them. This book makes all of my other neuroanatomy atlases
useless. Audience: The book is written for both radiologists and
surgeons looking to improve their knowledge of neuroimaging
anatomy. This book is perfect not only for people at the
attending level, but also for residents or anyone trying to
navigate through the complexities of neuroanatomy. The
authors are some of the top neuroradiologists in the country
and their publication demonstrates their expertise. Features:
Via both beautifully colored illustrations and detailed neuro-
imaging slides, the book covers all neuroanatomy including the
spine, head, and neck. The book is amazing in its detail, and the
quality of the images is unsurpassed. All structures are depicted
using multiple modalities (primarily computed tomography and
magnetic resonance imaging) in all three planes. The beauti-
fully colored art enhances the appearance and usefulness of the
book. If you are not familiar with the Diagnostic Imaging
series, you might have difficulty navigating the book at first
because its setup is unique. There are no real shortcomings to
the book, although there are one or two typographical errors.
Assessment: This is, by far, the best neuroimaging atlas. I have
many atlases, including Imaging Atlas of Human Anatomy, 3rd
edition, by Weir and Abrahams (Elsevier, 2003), Cross-
sectional Human Anatomy, by Dean and Herbener (Lippincott
Williams & Wilkins, 2000), Atlas of Human Anatomy, 4th
edition, by Netter (Elsevier, 2006), and Atlas of the Visible
Human Male, by Spitzer and Whitlock (Jones and Bartlett,
1997). For neuroanatomy, I can honestly say that my use of
these other sources will decrease dramatically, if not entirely.
Reviewer: Seth Jay Kligerman, MD, MS (University of
Colorado School of Medicine)