BURN WOUND HEALING ACTIVITY OF METHANOLIC

STEM EXTRACT OF Musa Paradisiaca Linn (BANANA)

IN WISTAR ALBINO RATS

CONCLUSION Arranged By:

The burn wound healing activity showed
Group 2
significant wound healing activity in Wistar Kartika Mutiara N.
albino rats; it may be due to the presence Linytha Silton Mutia Quratu A.
of its active principles, which accelerate Dalfa Indriani
the healing process and confer tensile strength Ajeng Septhiani
to the healed wound. Ghina Kholidaturizqi Siti Nurmanah
Wistar albino rat
Class 3A
BURN WOUND IS...
defined as coagulative destruction of the surface layers of the body.
PHARMACY MAJOR The priorities of specialized facilities focus on stabilizing the patient,
POLYTECHNIC OF HEALTH BANDUNG preventing infection, and optimizing functional recovery.
Banana stem 2016
 Musa Paradisiaca Linn Material and Method
Theoritical Background
1. Wistar albino rats weighing 120–150 g were used
have pharmacological activities, for burn wound healing model experiments; they
acute were physically active and were consuming food
that is... and water in a regular manner.
Can be acquired as a result of
-Antioxidant
Classification of wounds traumatic loss of tissue or
a surgical procedure. -Antibacterial
2. The Wistar albino rats were divided into two groups.
The depleted burn wound of 8mm diameter were created
chronic -Ulcer protective on the hind limb region of the rat by using red hot steel
-Wound healing rod under ether anaesthesia. The wound was left undressed
Are those that fail to progress through to the open environment and the animals were kept
the normal stages of healing and -Mutagenic effect individually in separate cages
they cannot be repaire.d in an orderly 3. After day 15, the experiment was
and timely manner terminated and the wound area
was removed from the surviving
animals for histological examination.

Chemical Constituent Result and Discussion

Wound healing process
The whole plant as well as spesific parts of plant extract and
its active contituents have been used for the treatment of 1. Wound healing activity
1. Coagulation and Haemostatis large number of human ailments.

2. Inflammatory Phase Flower

consists of tannins, saponins, reducing and non
3. Proliferative Phase
reducing sugars, sterols and triterpenes.
Banana bracts
4. Remodelling were investigated as a potential source of natural colourant.
Rats showed a time-dependent
Skin of the friut increase in percentage wound
Cellulose (10%), hemicelluloses (7%). contraction and closure rate.
Zone of Burn Wound Stem
rich of glucosides, tannis and alkaloids, saponins, flavonoids and
phenol.
Fruit
Carbohydrates, amino acids, sugar and starch.

Wound Healing
Significant increase in percentage of closure
Mechanism of Banana
by enhanced epithelisation. Tissue regeneration
- enhanced epitalization, was much quicker in the treated group compared
- reduce lipid peroxidation, the control group. It may be due to the effect of
- antimicrobial effect, methanolic stem extract of Musa paradisiaca linn.
- and increases the viability of collagen fibrils.