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1) Haploids are more suitable for mutation studies than the diploids. This is because?
अगुिणत िगुिणत की तुलना म उपिरवतन अययन के िलए अिधक उपयुत ह, योंिक
a) All mutations, whether dominant or recessive are b) Haploids are reproductively more stable than
expressed in haploids. diploids
c) Mutagens penetrate in haploids more effectively d) Haploids are more abundant in nature than
than diploids diploids
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िबंद ु उपिरवतन म शािमल है
a) Deletion b) Insertion
c) Change in single base pair d) Duplication
a) Characterized by elongated sickle like RBCs with a b) An autosomal linked dominant trait
nucleus
c) Caused by substitution of valine by glutamic acid in d) Caused by a change in a single base pair of
the beta globin chain of defected haemoglobin DNA
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सबसे लोकिपय लड गु िपंग पणाली ABO गु िपंग है। इसे ABO नाम िदया गया है न िक ABC, योंिक O इसम इसका उलेख करता है
5) Which one of the following cannot be explained on the basis of Mendel’s law of dominance?
िननिलिखत म से िकसे मडल के पभु व के िनयम के आधार पर नही ं समझाया जा सकता है
a) Alleles do not show any blending and both the b) Factors occur in pairs
characters recover as such in F2 generation
c) The discrete unit controlling a particular character d) Out of one pair of factors on is dominant, and
is called a factor the other recessive
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उपिरवतन इसके साथ पेिरत िकया जा सकता है
7) If both parents are carriers for thalassemia, which is an autosomal recessive disorder, what are
the chances of pregnancy resulting in an affected child?
े ीिमया के वाहक ह, जो एक ऑटोसोमल िरसेिसव िडसऑडर है, तो गभधारण म पभािवत बचे की संभावना या है
यिद माता-िपता दोनों थैलस
a) No chance b) 50%
c) 25% d) 1
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वैश म फलों का रंग इसका एक उदाहरण है
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एक िलंकेज समूह से दूसरे म जीन की गित को कहा जाता है
a) Inversion b) Duplication
c) Translocation d) Translation
11) Which is the most common mechanism of genetic variation in the population of a sexually
reproducing organism?
लिगक प से पजनन वाले जीवों की जनसंया म आनुवंिशक िभनता का सबसे सामाय तं कौन सा है
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एलेस ह
13) A man with blood group A marries a woman with blood group B. What are the possible blood
groups of their offspring?
लड गु प वाला आदमी A, लड गु प B वाली मिहला से शादी करता है। उनकी संतानों के संभािवत लड गु प या हो सकता ह
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कॉलम II म उनके िववरण के साथ कॉलम I की शत का िमलान कर और सही िवकप चुने
15) In a test cross involving F1dihybrid flies, more parental type offspring were produced than the
recombinant type offspring. This indicates?
F1 िसंकर मिखयो को शािमल करने वाले एक परीण ॉस म, पुनःसंयोजक पकार के संतानों की तुलना म अिधक माता - िपता पकार की
संतानों का उपादन िकया गया था। यह इंिगत करता है, इसको
a) The two genes are located on two different b) Chromosomes failed to separate during meiosis
chromosomes
c) The two genes are linked and present on the same d) Both of the characters are controlled by more
chromosome than one gene
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िसकल सेल एनीिमया और हंिटं गटन कोिरया दोनों ह
17) Lack of independent assortment of two genes A and B in fruit fly drosophila is due to?
a) Repulsion b) Recombination
c) Linkage d) Crossing over
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ि-डू -चैट िसंोम गुणसू संरचना म इस पिरवतन के कारण होता है
a) Deletion b) Duplication
c) Inversion d) Translocation
19) Which one of the following is the most suitable medium for culture of drosophila melanogaster?
िननिलिखत म से कौन सा ोसोिफला मेलानोगाटर के संवधन के िलए सबसे उपयुत मायम है
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एक जीन जो दूसरे जीन की अिभयित को िछपाता है, वह कहा जाता है
a) Dominant b) Recessive
c) Epistatic d) Assorted
21) Which one of the following abnormalities results from an unnatural presence of a Barr body that
it would normally not have?
िननिलिखत म से कौन सी असामायताएं शरीर म अपाकृितक प से बॉर काय की उपिथित के पिरणामवप होती ह जो िक सामाय प से
नही ं पायी जाती ह
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बॉर काय इसम मौजूद है
a) Sperm b) Ovum
c) Somatic cell of female d) Somatic cell of male
23) Mendel’s principle of segregation means that the germ cell always receive?
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नेफै िटस (Alport syndrome) इसका एक उदाहरण है
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resemble either parent?
गेहूं म अनाज का रंग तीन जोड़ी पॉलीजीन ारा िनधािरत िकया जाता है। AABBCC (डाक कलर) x aabbcc (लाइट कलर) को ॉस
करने पर, F2 जनरेशन म संतान िकस अनुपात के अपने िकसी भी पालक के समान है
a) 1 / 16 b) 1 / 32
c) 1 / 8 d) 1 / 4
a) Glucokinase b) Hexosaminidase A
c) Pyruvate kinase d) ATPase
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हॉलिक जीन इस पर िथत ह
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एचेिरिचया कोलाई म मौजूद िलंकेज गु प की संया है
a) One b) Two
c) Four d) Seven
31) The one aspect which is not a salient feature of genetic code, is its being?
a) Specific b) Degenerate
c) Ambiguous d) Universal
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सैटेलाइट डीएनए इसम उपयोगी होता है
33) PCR and restriction fragment length polymorphism are the methods for?
पीसीआर और रेिशन फे गमट लथ पॉलीमॉरिफम इसके िलए उपयोग िकये जाने वाले तरीके ह
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िननिलिखत म से कौन डीएनए म एक पितलेखन इकाई का िहसा नही ं है
a) Codes for enzymes needed for DNA replication b) Codes for proteins needed in cell cycle
c) Shows high degree of polymorphism in population d) Does not code for proteins and is same in all
and also the some degree of polymorphism in an members of the population
individual, which is heritable from parents to children
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आनुवंिशक सामगी के संगठन के सही म को सबसे बड़े से सबसे छोटे तक पहचाने
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आरएनए के एकल ड से जुड़े कई राइबोसोम का एक जिटल जाना जाता है
a) Polysome b) Polymer
c) Polupeptide d) Okazaki fragment
39) Which of the following statements is not true for cancer cells in relation to mutations?
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एक पोषक प से जंगली पकार का जीव, िजसे विृ के िलए िकसी भी अितिरत पूरक पदाथ की आवयकता नही ं होती है, वह जाना जाता है
a) Phenotype b) Holotype
c) Auxotroph d) Prototroph
a) Denaturation of DNA on the gel for hybridization b) Production of a group of genetically identical cells
with specific probe
c) Digestion of DNA by restriction enzyme d) Denaturation of DNA from a nucleated cell such as
the one from the scene of crime
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शारीिरक आनुवंिशकी के जनक या जैव रासायिनक आनुवंिशकी के िपता के प म िकसे जाना जाता है
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ोमोसोम का सॅटॅलाइट भाग है
a) Rich in RNA and deficient in DNA b) Rich in DNA and deficient in RNA
c) Rich in protein d) Lacks DNA
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लेक ऑपेरॉन मॉडल म, लैटोज अणु इसके प म काय करते ह
a) Inducers, which bind with the operator gene b) Repressors, which bind with the operator gene
c) Inducers, which bind with the repressor protein d) Corepressors, which bind with repressors protein
47) What is incorrect about the following figure representing DNA replication?
डीएनए पितकृित का पितिनिधव करने वाली िनन आकृित के बारे म या गलत है
a) The direction of DNA replication in strand (i) b) The direction of DNA replication in strand (ii).
c) Discontinuous replication of strand (i) d) Discontinuous replication of strand (ii).
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tRNA की मशः mRNA और अमीनो एिसड के साथ बायकारी साइट है
a) mRNA with DHU loop and amino acid with CCA b) mRNA with CCA end and amino acid with
end. anticodon loop.
c) mRNA with anticodon loop and amino acid with d) mRNA with anticodon loop and amino acid with
DHU loop. CCA end.
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वैािनक ओकाज़ाकी को इसम उनके योगदान के िलए जाना जाता है
a) Transcription b) Translation
c) DNA replication d) Mutation
a) A radioactively labeled double stranded RNA b) A radioactively labeled double stranded DNA
molecule molecule
c) A radioactively labelled single stranded DNA d) A radioactively labelled single stranded RNA
molecule molecule
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िलिसंग के दौरान, एसॉन आपस म जुड़ जाते ह और एंजाइम जो इस पितिया को उपेिरत करता है, वह है
53) Who suggested that an intermediate RNA molecule would be needed to read the codons on
mRNA?
िकसने सुझाव िदया िक mRNA पर कोडों को पढ़ने के िलए एक मयवत RNA अणु की आवयकता होगी
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िसमा कारक इसका एक घटक है
55) In Hershey and chase experiments, radioactive Phosphorus was used to culture bacteriophages.
It resulted in radioactive?
हश और चेस पयोगों म, रेिडयोएिटव फॉफोरस कचर म विधत बैटीिरयोफेज का उपयोग िकया जाता है। इसके पिरणाम वप यह
रेिडयोसीय हो जाएगा
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snRNAs इसकी मदद से अनुलिे खत होते है
a) Tailing b) Splicing
c) Capping d) None of the above
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इस के िलए UUU कोड होता है
a) Leucine b) Methionline
c) Phenylalanine d) Glycine
59) Many non - humans model organisms have also been sequenced along with the humans genome,
these are?
कई गैर-मानव मॉडल जीवों को भी मानव जीनोम के साथ अययन िकया गया है, ये ह
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वचािलत डीएनए िसव िसंग इनके ारा िवकिसत िकया गया है
Answers
1) A. Haploids have only one set of chromosome hence only one gene will be present dominants or
recessive.
3) D. Sickle cell anemia is an autosomal recessive disorder that is inherited. The RBC s of a person
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with sickle – cell anemia contains HbS, an abnormal kind of haemoglobin. When HbS, gives up
oxygen to the interstitial fluid, it forms long, stiff, rod like structures that bend the erythrocyte into a
sickle shape. The sixth position in the normal beta chain has glutamic acid, while sickle beta chain
has valine. Sickle - cell anemia is caused by a point mutation in the β - globin chain of hemoglobin,
causing the hydrophilic amino acid glutamic acid to be replaced with the hydrophobic amino acid
valine at the sixth position. The β-globin gene is found on the short arm of chromosome 11.
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5) A. Mendel’s law of dominance states that on doing a cross between parents of pure line with
contrasting traits the progeny obtained will exhibit character of only one type of trait which is
dominant. It does not explain segregation in F2 generation.
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7) C. Thalassemia is an autosomal - linked recessive disorder. Suppose, AA is the genotype of a
normal person, Aa is the genotype if a carrier and aa is the genotype of an affected person, then the
cross between two carriers is showns - 1AA : 2Aa : 1aa
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colour. The outcome of a cross between plants heterozygous for both of the fruit colour determining
genes results in phenotype ratio 12 (white); 3 (yellow) : 1 (green). Therefore we can see that allele W
in one gene is dominant over all the alleles (Y and y) of the other gene, and thus epistatic over the
other gene. This is a case of dominant epistasis.
9) C. Multiple alleles are present at the same locus of chromosome, population of organism typically
includes multiple alleles at each locus among various individuals. Allelic variation at a locus is
measurable as the number of alleles (polymorphism) present, or the proportion of heterozygotes in
the population.
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establishment.
11) D. Recombination is the most common way if producing genetic variation in sexually
reproducing organisms. During meiosis in eukaryotes, genetic recombination involves the pairing of
homologous chromosomes. This may be followed by exchange between the chromosomes which lead
to the formation of new traits in off springs.
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parent.
13) C. All the four types of blood group are possible as person with blood group A i.e IA may be AA
or AO similarly person with blood group B i.e IB may be BB or BO, so there is possibility of all the
blood group in the off springs.
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14) B. (i) Dominance - A relationship between two alleles of one gene, in which one allele is
expressed even in heterozygous condition. (ii) Codominance -When two equally dominant factors
coexist, neither allele is dominant, or even partially dominant, over the other. (iii) Pleiotropy - When
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a single gene controls multiple phenotypes that are mostly unrelated. Polygenic inheriatnce - A
genetic inheritance by which a trait is determined by combined effect loci of the chromosome.
15) C. Complete linkage is defined as the state in which genes closely located in the chromosome are
so close together they are virtually never separated by crossing over and are always transmitted
together, thus the proportion of parental gene combinations are much higher than the non – parental
or recombinant type.
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17) C. W. Bateson explained the lack of independent assortment in sweet pea and T.H Morgan in
Drosophila is due to linkage. When genes closely present adhere or link together in a group and
transmitted as single unit, the phenomenon is called linkage.
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19) C. Drosophila melanogaster is used in genetic and development biology researches. The ripe
banana is the most suitable medium for the culture of this fly.
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21) C. In the case of klinefelter’s syndrome, the male possess a Barr-body, while in the case of
Turner’s syndrome, the Barr body is absent.
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23) C. Mendel’s principle of segregation states that during the formation of gametes by meiosis the
paired contrasting factors (alleles) separate or segregate so that each gamete receives only one of
these factors in equal proportions.
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25) D. Myelogenous leukemia is caused by reciprocal translocation between a part of long arm of
chromosomes 22 to chromosome 9 it brings about change in the conformation of C-Abl protein.
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27) B. Tay – sach’s disease is caused by a mutant HEXA gene (which encodes the enzyme
hexosaminidase A) inherited to homozygous individuals.
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28) B. Holandric genes are located only on Y - chromosome. Therefore, the only carrier is males. It is
a Y-linked gene which is transmitted from father to son.
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29) C. Sickle cell anemia is an autosomal recessive disorder that is inherited. People with two sickle
–cell genes have severe anemia those with only one defective gene has the sickle cell trait.
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31) C. Codons are non-ambiguous except GUG.
33) B. PCR and RFLP are used to produce DNA fingerprints during genetic fingerprinting.
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34) C. A transcription unit has three components, a promoter, the structural gene and a terminator.
35) C. The satellite DNAs in eukaryotes has long repetitive sequences. They do not code for any
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proteins but exhibit polymorphism on which DNA fingerprinting is based.
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37) A. Chargaff rules are applicable only on double stranded DNA.
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39) D. Mutations in the genes that regulate cell growth and cell division can result in cancer. This
difference in growth potential is often attributed to the presence of telomerase (enzyme that
maintains the telomeres at the ends of the chromosomes) in cancer cells and its absence in normal
cells. Cancerous cells have high telomerase activity. Telomerase inhibitors are used in cancer
treatment.
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41) C. The steps to carry out the southern blot technique are :
I. Digestion of DNA by restriction enzyme to prepare restriction fragment
II. Separation of these fragments by gel electrophoresis
III. Denaturation of DNA on the gel for hybridization with specific probe
IV. Single stranded DNA obtained is transferred on nylon membrane
V. Use of radioactive probe
VI. Autoradiography
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43) B. According to Chargaff’s rule the concentration of thymine is equal to adenine concentration
and cytosine concentration is equal to guanine concentration (T = A and C = G). this data indicated
that the total amount of purines (adenine and guanine) is equal to the total amount of pyrimidines
(thymine and uracil). Hence (A+G = C +T).
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45) D. Translocation is the final step in the chain elongation during protein synthesis. Translocation
of the ribosome along the mRNA from codon to codon is bought about by elongation factor G also
known as Translocase. This helps to position the next codon in the A site.
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47) C. DNA polymerase can polymerize nucleotides only in 5’3’ direction on 3’ 5’ strand because it
adds them at the 3’ end. Since the two templates provide different ends for replication. Replication
over the two templates thus proceeds in opposite directions. One stand with polarity 3’5’ forms its
complementary strand continuously because 3’ end of the latter is open for elongation. It is called
leading strand. Replication is discontinuous on the other template with polarity 5’3’ because only a
short segment of DNA strand can be built in 5’3’ direction due to exposure of a small stretch of
template at one time. Short segments of replicated DNA are called Okazaki fragments.
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52) A. RNA ligase
53) C. F. Crick
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54) C. RNA polymerase
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56) D. RNA polymerase III
57) C. Capping
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58) C. Phenylalanine
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60) D. Frederick sanger
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