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IDENTIFICATION DATA
Name: Aziah bt Nordin
I/C no: 520220-08-6256
R/N: 479266
Age: 55 years old
Gender: Female
Ethnicity: Malay
Religion: Islam
Address: Tok Sira, Telok Cempedak
Occupation: Not worked
Marital status: Single
Date of admission: 1 January 2007
Date of clerking: 5 January 2007
CHIEF COMPLAINT
Right breast lesion for more than 2 month
She also noticed of right upper limb swelling since she realized the breast lump. It occurred after
she ate prawn. The swelling was progressively increased. It was not red, no pain, tender or
itchiness, no numbness and not affect her movement or sensation. She claimed to be able to do
house chores such as wash cloth and dishes. She never seeks treatment for the swelling.
On further questioning, she claimed that she had on and off low grade fever for more than 6
month ago. It was sudden in onset with no specific pattern or spiking in nature. The fever
resolved after she took anti-pyretic. It was not associated with chills, rigor, night sweating, cough,
runny nose, vomiting, diarrhea, abdominal pain, increase in urinary frequency, pain during
micturation, headache or alteration in behaviour. She also had no easily bruising, gum or teeth
bleeding, joint pain, muscle pain or easily lethargy. She had no contact with Tuberculosis patient.
She also had loss of appetite since the recurrent fever but did not notice any loss of weight.
Two days prior to admission, she had moderate to high grade fever which associated with chills
and rigor. The fever was sudden in onset and was constant. The fever was not spiking and not
associated with night sweat. The fever was not relief by anti-pyretic. She also experienced about
5 times vomiting since the fever. The vomiting occurred after meals and contains food particles
and fluid. The vomiting was non-projectile and had no blood, bile or fecal odour. The amount of
each vomiting is about 1 tea cup. Besides, a day before admission, she also had 2 episodes of
diarrhea which she passed out loose stool. There was no bleed or mucous noted. However, there
were no changes in odour, colour or amount of the stool. There was no complained of abdominal
pain. There was no history of eating outside or change in dietary habit. She also complained of
mild giddiness since the onset of diarrhea. However, there was no fainting attack.
The family members then brought her to Hospital Tengku Ampuan Afzan as they just also knew
about the breast lesion.
REVIEW OF SYSTEMS
Gastrointestinal system: there is no history of abdominal pain, dysphagia, regurgitation, rectal
bleeding, heartburn, flatulence, abdominal distention, incontinence, vomiting of blood, tenesmus,
constipation.
Cardiovascular system: there is no history of retrosternal pain, orthopnea, ankle oedema,
paroxysmal nocturnal dyspnoea, cyanosis or claudication.
Respiratory system: no history of chest pain, cough, haemoptysis, wheezing or stridor.
Central nervous system: no history of head injury, syncope, loss of consciousness, dizziness,
muscle weakness, fit or blurring of vision.
Genitourinary system: no history of dysuria, nocturia, haematuria, frequency, urgency,
hesitancy, urinary incontinence, vaginal or urethral discharge.
Musculoskeletal system: no history of joint or back pain, joint swelling, stiffness or deformity,
muscle pain or locking of joints.
Dermatological system: no history of rashes, pruritus.
Haematological system: no history of pallor.
SOCIAL HISTORY
She is a single and nulliparous lady. She didn’t work and lives with her sister. She is
taking care of her sister’s children. She is a non-smoker, never consume alcohol, and not drug
abuser or sexual promiscuity. She had normal adult diet. She denied any exposure to radiation.
PHYSICAL EXAMINATION
GENERAL INSPECTION
On inspection, she was lying supine comfortably, alert, concious and cooperative. She was not in
pain and not dyspnoeic or tachypnoeic. She looked pink and no signs of cyanosis. Her nutritional
status and hydrational status were fair without any evidence of coated tongue. There was gross
oedema at the right upper arm. There was branula attach to the dorsum of left hand.
GENERAL EXAMINATION
Vital Signs:
Blood pressure: 109/63 mmHg
Pulse rate: 88 beat per min
Respiratory rate: 18 breath per min
Body temperature: 37.5 °C
Head : tongue was not coated and not dry, no central cyanosis
oral hygiene was fair
pharynx and tonsil were not inflammed
no discharge from ears
no lymphadenopathy
Breast Examination:
Inspection -in semi recumbent (450) position:
• Arms by the sides: Normal size, well developed, symmetry, and normal contour, no overlying
skin changes (no puckering, oedema, nodularity, discoloration or ulceration) on the left
breast. The right breast looked dark, ulcerating, oedematous, satellite nodule and the lesion
was ill-defined measured around 10 x 8 cm, at the lower outer and lower inner quadrant.
There was no blood. There was also pus discharge at the lesion, some necrotic changes and
granulation tissues. The floor consists of solid yellowish-brown or grey dead tissue. There
was nipple retraction on the right breast. There was also foul in smelling. The nipple at the
left breast was normal. There was no visible enlargement of the axillary or supraclavicular
lymph node or distended veins.
• When the patient raised her arms above her head: there was no changes in the appearance of
the breast. Lower surfaces of the breasts were normal. No visible axillary swelling,
discoloration, puckering or ulceration.
• Hands pressed against her hips: No visible lump or skin changes were seen.
• Patient bend forward: both breasts fall freely off the chest wall.
• There was pitting oedema on the right arm, erythematous, not warm, the capillary refill time
is less than 2 second and the pulse was good.
• No venous, artery or neurological abnormalities.
Cardiovascular system:
On inspection, the chest was normal without any deformity. The pulse was normal in rate
(88/min), volume, and rhythm and bilaterally equal in the radial, carotid and femoral arteries. The
artery was normal in character – there was no thickening or hardening.
There was no visible Jugular Venous Pressure.
The apex beat is ffelt in the 5th intercostal space, medial to the mid-clavicular line, on the right
side.
On auscultation, the first and second hearts sounds were audible i.e. dual rhythm was normal.
There were no murmurs, no thrills.
Respiratory system:
On inspection, there was no chest deformity, the anteroposterior diameter was not increased, no
barrel chest. The respiratory rate was 18/min, she was not tachypnoeic and there was no
wheezing. There was no flaring of alae nasai. There was no usage of accessory muscles, no
subcostal, intercostal or suprasternal recession.
On palpation, there was no tracheal deviation, the chest expansion was symmetrical, and the
vocal fremitus was equal on both sides.
On percussion, the chest was normal resonance.
On auscultation, the air entry was equal and bilateral with presence of ronchi. There was no
crepitation. Vocal resonance was normal and equal.
Abdomen Examination:
On inspection, the abdomen was not distended and normal in shape. It moved with respiration.
No evidence of surgical scar, dilated veins or abnormal peristaltic movement. The umbilicus was
inverted and centrally located.
On superficial palpation, the abdomen was soft and no masses detected. There was no guarding
or tenderness. On deep palpation, the liver and spleen are no palpable. The kidneys are not
ballotable. No herniation noted.
On percussion, shifting dullness was negative and no signs of fluid thrill. On auscultation, bowel
sound was present and there was no bruit.
Per rectal examination was not done.
Musculoskeletal System:
The tone, power and reflex were normal. There was no proximal muscle weakness or
hyperreflexia.
Grossly intact.
CASE SUMMARY
Aziah bt. Nordin, a 55 years old, nulliparous, Malay lady from Tok Sira presented to
Hospital Tengku Ampuan Afzan with a right breast lesion for more than 2 month duration prior
to admission. There was pus discharged, ulcer and skin darkening. There was also lump sized of
20 cent present which was hard and immobile. There was also right arm swelling for 1 month.
She also complains of on and off low grade fever for the past 6 month without any symptoms of
upper respiratory tract infection, urinary tract infection, gastrointestinal tract infection or
meningitis. She also experienced loss of appetite.
On physical examination, there was dark, ulcerating, oedematous, satellite nodule and the
lesion was ill-defined measured around 10 x 8 cm, at the lower outer and lower inner quadrant.
There was also pus discharge at the lesion, some necrotic changes and granulation tissues. The
floor consists of solid yellowish-brown or grey dead tissue.There was nipple retraction on the
right breast. There was also foul in smelling. There was a lump in the upper-outer quadrant of the
right breast. It was non-tender, normal temperature, 5x3 cm size, regular surface, well-defined
margin, hard, immobile, fixed to the skin and there was lesion at the surrounding area. There
were three palpable lymph nodes in the right axilla. They were in the central, medial and lateral
aspect, non-tender, normal temperature, 1x1 cm in size, hard and fixed. There was pitting oedema
on the right arm, erythematous, not warm, the capillary refill time is less than 2 second and the
pulse was good.
PROVISIONAL DIAGNOSIS
Advanced Breast Cancer
DIFFERENTIAL DIAGNOSIS
- Breast abscess
- Fibroadenoma
- Phylloides tumor
Breast abscess
Points for:
- There is pus discharge
- Enlarged axillary lymph nodes
Points against:
- More common in child bearing age
- Grow progressively within one week (acute onset)
- No history of trauma to the nipple
- Non tender
Fibroadenoma
Points for:
- Non tender
- Not noticed any changed in size
- Well defined margin
- Smooth surface
Points against:
- Usually in age <35 years old
- Immobile
- High risk factor for carcinoma
- Loss of appetite
- Palpable axillary lymh node
Phylloides tumor
Points for:
- Normal overlying skin
- Age 50 years old
- Enlarged axillary lymph node due to metastasis.
- Slow growing
Points against:
- No previous excision at the site of lump
- Moderate size lump
- No enlargement of the whole breast
INVESTIGATION
Result:
WBC 12.1 x 103 / µl ↑
RBC 5.01 x 106 / µl
HGB 9.3 g/dl
HCT 29.7%
MCV 59.3 fl ↓
MCH 18.6 pg ↓
MCHC 31.3 g/dl
Plt 190 x 103 / µl
Lymphocyte 12.1 %
1.5 x 103 / µl
RDW-CV 15.7%
PDW 12.1 fl
MPV 80 fl
Comments:
There is hypochromic microcytic anaemia. The white blood cell count is high may be due to
infection. The platlet count is normal.
Result:
10.8 mmols/L (N=3.9-6.1)
Comments:
High. The test should be repeated
Renal Profile
Purpose: To know the urea and other electrolyte status and detecting any imbalance
Results:
Urea 4.2 mmol/L
Sodium 141 mmol/L
Potassium 4.1 mmol/L
Chloride 102 mmol/L
Creatinine 69 µmol/L
Uric Acid 244 µmol/L
Comments: Normal
Results:
Total Bilirubin 15.3 µmol/L
Direct Bilirubin 2.7 µmol/L
Indirect Bilirubin 12.6 µmol/L
Total Protein 63.8 g/L
Albumin 28.7 g/L ↓
Globulin 35.1 g/L ↑
AG Ratio 0.8 ↓
Alkaline Phosphatase 118 U/L ↑
ALT 44 U/L ↑
AST 41 U/L ↑
Comments:
Albumin is reduced, globulin raised and A/G ratio is reduced. This may indicate that most
albumin bound to calcium. The liver enzymes are all increased could be evidence of
metastasized. This should be confirmed by other investigations such as abdominal ultrasound or
CT scan.
Result:
Organism isolated – Proteus Mirabilis
Ampicillin – sensitive
Ampicilin-Sulbactam – sensitive
Cefuroxime – sensitive
Cefoperazone – sensitive
Ceftriaxone – sensitive
Cephalexin – sensitive
Gentamicin – sensitive
Trimethoprim-Sulfamethaxazole – sensitive
Chest X-ray
Purpose: To asses the lung condition or any metastasis
Result:
No nodules noted. Normal lung tissues. Lytic lesion and bubbles appearance at the left clavicle.
Comments:
No lungs metastasize. ? bone metastasize of left clavicle
Coagulation Test
Purpose: To detect hematological disorders or metastasis (assess liver ability to produce factor II,
VII, IX, X)
Biopsy
Purpose: To do histopathological examination for malignancy
Result: Pending
Serum calcium
Purpose: To assess bone metastasis
A female breast overlies the 2nd to the 6th ribs. Two-thirds of it rests on pectoralis major,
one-third on the serratus anterior, while its lower medial edge just overlaps the upper part of
rectus sheath.
Breast is made up of 15-20 lobules of glandular tissue embedded in fat. This fats account
for its smooth contour and most of its bulk. These lobules are separated by fibrous septa running
from the subcutaneous tissues to the fascia of the chest wall (the ligament of copper).
Each lobule drains by its lactiferous duct on the nipple, which is surrounded by the
pigmented areola.
Blood supply:
1. lateral thoracic artery ( from axillary artery)
2. perforating branches of internal mammary artery.
3. lateral perforating branches of intercostals arteries.
Lymph drainage:
1. along tributaries of the axillary vessels to axillary lynph node.
5 group of axillary lymph nodes
• apical
• anterior
• posterior
• lateral
• central
2. along the tributaries of the internal thoracic vessels.
Rotters node is found between 2 pectoral muscles.
These lymphatic drainage is very important for the spread of growth of breast carcinoma.
PATHOLOGY
The female breast is a specialized gland that develops after puberty. The breast tissue
often responds to menstrual cycle of estrogen and progesterone. Hypertrophy and hyperplasia of
breast during pregnancy is a normal physiology.
Breast cancer is the commonest cause of cancer in developed country; however it is still
not uncommon in developing countries.
The cause of breast cancer is not known, some believe that dietary factors have a role in
its etiology, breast cancer is a predominantly a disease of females, however it can –rarely- still
occur in males where genetic factors play a big role. Early menarche and late menopause increase
risk of developing breast carcinoma. The usage of Oral Contraceptive Pills and Hormone
Replacement Therapy also increases risk. Another risk factor for breast carcinoma is age, as the
risk increases with age reaching the peak between 50-60 years. The Family history in breast
cancer is important as the susceptibility to it is inherited as an autosomal dominant trait, however
this patient possess no family history of the disease. Breast epithelial hyperplasia in the absence
of pregnancy is a risk factor for carcinoma. Factors associated with an increased risk factor
represent key step toward breast neoplasia. Early stage of disordered growth through loss of cell
cycle control can result in benign proliferative changes. BRCA1 & BRCA 2 are the 2 common
gene related in breast carcinoma. (BRCA1 is also associated with ovarian cancer, BRCA2
associated with breast cancer in male). HER2 over expression often leads to higher growth rate,
with more aggressive clinical behavior. Loss of expression of nm23, which encodes for a
nucleoside kinase, has been linked to an increased potential of lymphatic involvement as well as
lower survival rate.
The cancer once it invades the underlying skin or muscle, it will be fixed and difficult to
move. Metastasize occur through blood or lymphatics. When it involves the lymphatics along the
fibrous septa, blockage occurs leading to oedema of overlying skin between the many small pits
which mark the opening of hair follicle and sweat gland. Extensive involvement of the axillary
nodes may cause lymphoedema of the arm or venous thrombosis of superficial vein
(mondors disease). The lymph nodes on the other breast also can be enlarged. On the other hand
if it metastases via blood, then most likely it will spread to bone (giving rise to sciatica like
problem, bowel and urine disturbance), lung, liver and brain. The staging of cancer is done via
Manchester staging or TNM classification.
TNM CLASSIFICATION
T = TUMOR
TX = UNNOWN
TIS = TUMOR IN SITU
T1 = 2cm diameter. No fixation
T2 = 2-5cm diameter with tethering or nipple retraction
T3 = 5-10cm diameter + infiltration, ulceration, peau d’ orange or deep fixation
T4 = any tumor with infiltrating or ulceration wider than its diameter. > 10cm
T4a = Extension to chest wall
T4b = Edema, ulceration of the skin of the breast (including peau d’orange) or satellite skin
nodules confined to the same breast
T4c = Both (T4a and T4b)
T4d = Inflammatory carcinoma
N = NODES
NX = Node not assessable
N0 = no palpable axillary nodes
N1 = mobile palpable nodes
N2 = fixed axillary nodes
N3 = palpable supraclavicular nodes. Oedema of the arms.
M = METASTASES
MX = Metastasis not assessable
M0 = no evidence of distant metastases
M1 = distant metastases.
Stage and prognosis according to TNM classification – UICC (International Union against
Cancer)
My patient, Aziah Nordin, a 55 years old, nulliparous, Malay lady from Tok Sira
presented to Hospital Tengku Ampuan Afzan with a right breast lesion for more than 2 month
duration prior to admission. The lesion was increase in severity. It was also associated with hard,
immobile and painless lump which is typical characteristic in breast malignancy. She also had
symptoms of loss of appetite and recurrent fever for the last 6 month which may suggestive of
malignancy condition. Besides, she also had lympoedema at the right upper arm which suggestive
of lymphatic obstruction by tumor metastasis.
Initially, she was refused to seek medical treatment as the patient was in denial state. She
did not tell the family and only seek traditional treatment. However because of the worsen
condition such as high grade fever and vomiting, then the family found out that she had breast
lesion.
This patient had several risk factors for developing breast cancer. She is at the age of 55
years old, nulliparous woman and menopause quite late at the age of 52 years old. Hence, she had
prolonged hormonal factor. She also most probably had family history of breast cancer because
her mother had undergone mastectomy.
Upon physical examination, the breast lesion and lump suggestive of breast cancer.
Clinically, the staging was T4b N3 M1. Based on her condition, she is in metastatic category of
prognosis which 5 year chance survival is only 18%.
On investigations, she had hypochromic microcytic anaemia which may due to chronic
disease such as malignancy. Several investigations should be done to determine the definite site
of metastasis and hence treatment should be started once the patient is stable. In ward, she was
treated conservatively to reduce the arm swelling by elevation of the arm parallel to the waist and
went for physiotherapy. She also was encouraged ambulation to prevent thromboplebitis.
Cooperation should be achieved from the family members to make sure she’ll going to the
next appointment hence to proceed for further investigation and management.