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TON DUC THANG UNIVERSITY

FACULTY OF APPLIED SCIENCES


Department of Biotechnology

Chapter 2:
Production of bioactive secondary
metabolites
Course number: 601093

Lecturer: Dieu-Hien Truong

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Chapter 2. Production of bioactive secondary
metabolites

2.1. Isolation of bioactive secondary metabolites


2.2. Purification of bioactive secondary metabolites
2.3. Detection of bioactive secondary metabolites
2.4. Production of bioactive compound using bioreactor
technology
2.5. Production of bioactive compounds using in vitro cultures
2.6. Application of bioactive secondary metabolites
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 Bioactive secondary metabolites

Bioactive secondary metabolites are produced by microorganisms.


Netzker et al., 2015
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 Bioactive secondary metabolites

Bioactive secondary metabolites are produced by plants.


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 Bioactive secondary metabolites

- Chemical warfare to protect plants


from the attacks.
- Attract pollinators or seed dispersal
agents.
- Important for abiotic/biotic stresses.
- Medicine.
- Industrial additives.

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2.1. Isolation of bioactive secondary metabolites

Madhusudhan et al., 2015


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2.2. Purification of bioactive secondary metabolites

Sigamani et al., 2016


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2.3. Detection of bioactive secondary metabolites

Bringmann et al., 2003


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2.4. Production of bioactive compound using
bioreactor technology

Shim et al., 2015


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 Bioreactor techniques

601093 – Chapter 1. An introduction to biotechnology


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 Bioreactor techniques

601093 – Chapter 1. An introduction to biotechnology


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2.4. Production of bioactive compound using
bioreactor technology

Shim et al., 2015


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2.5. Production of bioactive compounds using
in vitro cultures

Mohammed et al., 2015


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 In vitro production of bioactive compounds

Phitsuwan et al., 2012


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 In vitro production of bioactive compounds

Xia et al., 2013


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2.6. Application of bioactive secondary metabolites

Zhang lab.
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2.6. Application of bioactive secondary metabolites

Weissman et al., 2010


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2.6. Application of bioactive secondary metabolites

Zhang lab.
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