IL6 Interleukin 6 Gene in Humans

27/4/2019 IL6 interleukin 6 [Homo sapiens (human)] - Gene - NCBI
IL6 interleukin 6 [ Homo sapiens (human) ]

Gene ID: 3569, updated on 23-Apr-2019 Hide sidebar >>
Summary
enome Browsers
enome Data Viewer
Official Symbol IL6 provided by HGNC
ariation Viewer (GRCh37.p13)
Official Full Name interleukin 6 provided by HGNC
Primary
ariation Viewer source HGNC:HGNC:6018
(GRCh38)
See related Ensembl:ENSG00000136244 MIM:147620
000 Genomes Browser
Gene (GRCh37.p13)
type protein coding
nsembl RefSeq status REVIEWED
Organism Homo sapiens
CSC Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria;
Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In
addition, the encoded protein has been shown to be an endogenous pyrogen capable of
inducing fever in people with autoimmune diseases or infections. The protein is primarily
produced at sites of acute and chronic inflammation, where it is secreted into the serum and
induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The
functioning of this gene is implicated in a wide variety of inflammation-associated disease
states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression Broad expression in urinary bladder (RPKM 9.7), gall bladder (RPKM 7.1) and 14 other
tissues See more
Orthologs mouse all
Genomic context
See IL6 in Genome Data Viewer

Location: 7p15.3
Exon count: 6
Annotation
Status Assembly Chr Location
release
109 current GRCh38.p12 7 NC_000007.14

(GCF_000001405.38) (22725889..22732002)
105 previous GRCh37.p13 7 NC_000007.13
assembly (GCF_000001405.25) (22766766..22771621)
Chromosome 7 - NC_000007.14
Genomic regions, transcripts, and products
Go to reference sequence details
Genomic Sequence: NC_000007.14 Chromosome 7 Reference GRCh38.p12 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank
https://www.ncbi.nlm.nih.gov/gene/3569 1/13
NC_000007.14 Find:
Genes, NCBI Homo sapiens Annotation Release 109, 2018-03-27
Biological regions, aggregate, NCBI NCBI Homo sapiens Annotat…

Warning: No track data found in this range
Genes, Ensembl release 96
Clinical, dbSNP b152 v2

Warning: No track data found in this range
Cited Variations, dbSNP b152 v2
Live RefSNPs, dbSNP b152 v2
RNA-seq exon coverage, aggregate (filtered), NCBI Homo sapiens Annotation Release 109 - log base
RNA-seq intron-spanning reads, aggregate (filtered), NCBI Homo sapiens Annotation Release 109 - l
RNA-seq intron features, aggregate (filtered), NCBI Homo sapi…
NC_000007.14: 23M..23M (7.9Kbp)
Expression
See details
HPA RNA-seq normal tissues
Project title: HPA RNA-seq normal tissues

Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different
tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018
20.0
17.5
15.0
12.5
RPKM
10.0
7.5
Bibliography
5.0
2.5
Related articles in PubMed
1. [The significance of interleukin-6 and polymorphism of its gene (C174G) under viral, alcoholic and mixed cirrhosis
0.0
of liver].
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Bulatova IA, et al. Klin Lab Diagn, 2017 Feb. PMID 30615393
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2. IL-6 in Osteoarthritis: Effects of Pine Stilbenoids.
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Laavola M, et al. Molecules, 2018 Dec 29. PMID 30597965, Free PMC Article
3. Single-Nucleotide Polymorphisms in Interleukin 6 (IL-6) Gene Are Associated with Suicide Behavior in an Iranian
Samples
Population.
Eftekharian MM, et al. J Mol Neurosci, 2018 Nov. PMID 30269203
4. Interleukin-6 Gene Polymorphism and the Risk of Systemic Inflammatory Response Syndrome Caused by Wasp
Sting Injury.
Sun Y, et al. DNA Cell Biol, 2018 Dec. PMID 30265566
5. Clinical significance of interleukin-6 in diagnosis of lung, oral, esophageal, and gall bladder carcinomas.
Vinocha A, et al. J Cancer Res Ther, 2018 Sep. PMID 30249899
See all (4322) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions What's a GeneRIF?
1. Levels of serum IL-6, peripheral blood mononuclear cells IL-6 mRNA transcription and IL-6 protein expression
were higher in the viral infection group than in the bacterial infection group.
2. The IL6 -174 G/C polymorphism may be negatively associated with risk of periodontitis (meta-analysis).
3. Simultaneous positivity of serum IL-6 either with synovial IL-6 or synovial CRP almost excludes false negative
detection of prosthetic joint infection at the site of interest.
4. study reveals that miR-204-5p inhibits the inflammation and chemokine generation in renal tubular epithelial cells
by modulating the IL6/IL6R axis.
5. Results show that enhanced interleukin 6 (IL-6)/phosphorylated STAT3 transcription factor (pSTAT3) signaling
may contribute to promotion of follicular helper T (Tfh) cells Tfh cells, consequently skewing the ratio of Tfh to
follicular regulatory T (Tfr) cells, which may be crucial for disease progression in rheumatoid arthritis (RA).
6. IL-6 confers a growth advantage in glioblastoma (GBM) cells but does not have the same effect on normal neural
progenitor cells. IL-6 can promote radioresistance in GBM cells when exposed to ionising radiation. Ablation of
ATM that is recruited and activated by DNA double-strand breaks reverses the effect of radioresistance and re-
sensitised GBM to DNA damage thus leading to increase cell death.
7. The increase in BAFF, IL-6, and IL-8 in induced sputum suggests a specific ongoing inflammatory disease
process in the airways in primary Sjogren's syndrome patients.
8. The polymorphism status of the ASIC1 and IL-6 genes.
9. Meta analysis shows significant association between IL6-174 polymirphism and recurrent aphthous stomatitis
risk.
10. Concentrations of CC-16 and IL-6 were higher in grain dust exposed workers
Submit: New GeneRIF Correction See all GeneRIFs (3479)
Phenotypes
Find tests for this gene in the NIH Genetic Testing Registry (GTR)
Review eQTL and phenotype association data in this region using PheGenI
Associated conditions
Description Tests
Cerebral arteriovenous malformation
Compare labs
MedGen: C0917804, OMIM: 108010, GeneReviews: Not available
Diabetes mellitus type 1

Compare labs
Inflammatory bowel disease 1

Compare labs
Kaposi's sarcoma
Compare labs
Rheumatoid arthritis, systemic juvenile

Compare labs
NHGRI GWAS Catalog
Description
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
NHGRI GWA Catalog
NHGRI GWA Catalog, PubMed
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
NHGRI GWA Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-
associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular
disease.
NHGRI GWA Catalog
Variation
See variants in ClinVar

See studies and variants in dbVar
See Variation Viewer (GRCh37.p13)
See Variation Viewer (GRCh38)
Genotypes
See SNP Geneview Report
See 1000 Genomes Browser (GRCh37.p13)
HIV-1 interactions
Replication interactions
Interaction Pubs
HIV-1 infection increases basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA,
PubMed
and CEBPG in monocyte derived macrophages
HIV-1 ADA infection decreases production of CXCL8 (IL8), CCL2 (MCP-1), and
IL6 at a basal level or after Fc receptor, complement receptor 3, or bacterial PubMed
stimulation in primary human macrophages
Protein interactions
Items 1 - 20 of 87 << First < Prev Page 1 of 5 Next > Last >>
Protein Gene Interaction Pubs
Envelope HIV-1 CN54, JRFL, and Ada Env (gp120) upregulates IL-6, CCL2, CCL4, CXCL8,
surface and IL-1b through TLR4 and CCR5 induction in monocyte derived macrophages
env PubMed
glycoprotein and hepatic stellate cells because treatment with an anti-TLR4 antibody mitigated
gp120 the response
HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2
env (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 PubMed
(I309) in stimulated monocyte derived macrophages
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood
env mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, PubMed
tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
Curcumin, a potent and safe anti-inflammatory compound, inhibits HIV-1 gp120-
env mediated upregulation of the proinflammatory cytokines TNF-alpha and IL-6, and PubMed
the chemokines IL-8, RANTES, and IP-10 in primary human genital epithelial cells
HIV-1 gp120-induced release of IL-6 activates STAT3 in primary human
env PubMed
monocyte-derived dendritic cells
HIV-1 gp120-induced release of IL-6 is regulated by p38 MAPK, IkappaBalpha,
env PubMed
and p65 NF-kappaB activation in primary human monocyte-derived dendritic cells
Interaction of HIV-1 gp120 with CCR5 upregulates IL-6 expression in primary
env PubMed
human monocyte-derived dendritic cells
HIV-1 gp120-induced release of IL-6 and MCP-1 is partially responsible for the
env PubMed
impairment of barrier function in human retinal pigment epithelial cells
HIV-1 gp120 stimulates monocytes to release TNF-alpha, IL-1 beta, IL-6, and
env PubMed
granulocyte-macrophage-CSF, and this effect can be blocked with soluble CD4
HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling
env PubMed
pathway and the PI3K/Akt signaling pathway in astrocytes
Protein Gene Interaction Pubs

HIV-1 gp120-induced expansion of myeloid derived suppressor cells is dependent
env PubMed
on the upregulation of IL-6 by gp120
HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and
env PubMed
IL-6 dependent STAT3 in immature dentritic cells
HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to
env PubMed
suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells
HIV-1 gp120 downregulates HIV-1 Nef dependent IL-6 release, which requires the
env PubMed
interaction of gp120 with DC-SIGN
HIV-1 gp120 induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL-
env PubMed
10, and TNF-alpha in immature dentritic cells
HIV-1 gp120 inhibits CpG-A-induced secretion of TNF-alpha, IL-6, and IP-10
env PubMed
proteins in plasmacytoid dendritic cells and PBMCs
HIV-1 gp120 induces a time-dependent IL-6 upregulation by translocating NF-
env PubMed
kappaB1 from cytoplasm to nucleus in human astrocyte cells
HIV-1 gp120 inhibits TLR9-mediated upregulation of CD83 and the secretion of
env inflammatory cytokines TNF-alpha and IL-6, and chemokine IP10 in plasmacytoid PubMed
dendritic cells (pDC)
Treatment of human hepatic stellate cells with gp120 significantly increases
env secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. PubMed
Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK)
HIV-1 gp120 activates human brain micro vascular endothelial cells (HBMEC) via
env CD4 in upregulating ICAM-1 and VCAM-1 expression, IL-6 secretion and PubMed
increased monocyte transmigration across monolayers
Go to the HIV-1, Human Interaction Database
Pathways from BioSystems
AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)

AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
Adipogenesis, organism-specific biosystem (from WikiPathways)
African trypanosomiasis, organism-specific biosystem (from KEGG)
African trypanosomiasis, conserved biosystem (from KEGG)
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, conserved biosystem (from KEGG)
Antifolate resistance, organism-specific biosystem (from KEGG)
Antifolate resistance, conserved biosystem (from KEGG)
Cellular Senescence, organism-specific biosystem (from REACTOME)
Cellular responses to stress, organism-specific biosystem (from REACTOME)
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)

Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
Development and heterogeneity of the ILC family, organism-specific biosystem (from WikiPathways)
Differentiation Pathway, organism-specific biosystem (from WikiPathways)
EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
Folate Metabolism, organism-specific biosystem (from WikiPathways)
FoxO signaling pathway, organism-specific biosystem (from KEGG)
Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
Graft-versus-host disease, organism-specific biosystem (from KEGG)
Graft-versus-host disease, conserved biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, conserved biosystem (from KEGG)
Hematopoietic Stem Cell Differentiation, organism-specific biosystem (from WikiPathways)
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystem (from WikiPathways)
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, conserved biosystem (from KEGG)
Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
IL-17 signaling pathway, organism-specific biosystem (from KEGG)
IL-17 signaling pathway, conserved biosystem (from KEGG)
IL-6 signaling pathway, organism-specific biosystem (from WikiPathways)
IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Immune System, organism-specific biosystem (from REACTOME)
Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, conserved biosystem (from KEGG)
Insulin resistance, organism-specific biosystem (from KEGG)
Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
Interleukin-6 family signaling, organism-specific biosystem (from REACTOME)
Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
Intestinal immune network for IgA production, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
Legionellosis, organism-specific biosystem (from KEGG)

Legionellosis, conserved biosystem (from KEGG)
Lung fibrosis, organism-specific biosystem (from WikiPathways)
MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
MAPK1 (ERK2) activation, organism-specific biosystem (from REACTOME)
MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
MAPK3 (ERK1) activation, organism-specific biosystem (from REACTOME)
Malaria, organism-specific biosystem (from KEGG)
Malaria, conserved biosystem (from KEGG)
Measles, organism-specific biosystem (from KEGG)
Measles, conserved biosystem (from KEGG)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
Overview of nanoparticle effects, organism-specific biosystem (from WikiPathways)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, conserved biosystem (from KEGG)
Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystem (from WikiPathways)
Photodynamic therapy-induced NF-kB survival signaling, organism-specific biosystem (from WikiPathways)
Prion diseases, organism-specific biosystem (from KEGG)
Prion diseases, conserved biosystem (from KEGG)
RAF-independent MAPK1/3 activation, organism-specific biosystem (from REACTOME)
Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystem (from KEGG)
Salmonella infection, organism-specific biosystem (from KEGG)
Salmonella infection, conserved biosystem (from KEGG)
Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
TLR4 Signaling and Tolerance, organism-specific biosystem (from WikiPathways)
TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF signaling pathway, organism-specific biosystem (from KEGG)
TNF signaling pathway, conserved biosystem (from KEGG)
Th17 cell differentiation, organism-specific biosystem (from KEGG)

Th17 cell differentiation, conserved biosystem (from KEGG)
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem (from WikiPathways)
Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Transcription factor regulation in adipogenesis, organism-specific biosystem (from WikiPathways)
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, conserved biosystem (from KEGG)
Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway
Interaction Database)
Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
Interactions
Other
Products Interactant Complex Source Pubs Description
Gene
IL6 interacts with IL6R (IL-6R-

NP_000591.1 NP_000556.1 IL6R BIND PubMed
alpha)
P05231 P08887 IL6R HPRD PubMed
P05231 P40189 IL6ST HPRD PubMed
P05231 P12272 PTHLH HPRD PubMed
P05231 Q99962 SH3GL2 HPRD PubMed
P05231 Q05516 ZBTB16 HPRD PubMed
BioGRID:109783 BioGRID:109505 HRH1 BioGRID PubMed Co-localization
Affinity Capture-Western;
BioGRID:109783 BioGRID:109784 IL6R BioGRID PubMed
Reconstituted Complex
BioGRID:109783 BioGRID:112353 SH3GL2 BioGRID PubMed Two-hybrid
BioGRID:109783 BioGRID:113498 ZBTB16 BioGRID PubMed Co-localization
General gene information
Markers
Homology
Homologs of the IL6 gene: The IL6 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, and chicken.
Orthologs from Annotation Pipeline: 216 organisms have orthologs with human gene IL6
Orthologs
Gene Ontology Provided by GOA
Evidence
Function Pubs
Code
cytokine activity IDA PubMed
cytokine activity ISS
Evidence
Function Pubs
Code
cytokine activity NAS PubMed

growth factor activity IDA PubMed
interleukin-6 receptor binding IPI PubMed
contributes_to interleukin-6 receptor binding IPI PubMed
interleukin-6 receptor binding NAS PubMed
protein binding IPI PubMed
Evidence
Process Pubs
Code
T-helper 17 cell lineage commitment ISS
acute-phase response TAS PubMed
cellular protein metabolic process TAS
cellular response to hydrogen peroxide IDA PubMed
cellular response to lipopolysaccharide IMP PubMed
cytokine-mediated signaling pathway IDA PubMed
cytokine-mediated signaling pathway TAS
defense response to Gram-negative bacterium TAS PubMed
defense response to Gram-positive bacterium TAS PubMed
defense response to virus IDA PubMed
endocrine pancreas development ISS
glucagon secretion ISS
hepatic immune response IDA PubMed
hepatic immune response TAS PubMed
humoral immune response IC PubMed
inflammatory response IDA PubMed
interleukin-6-mediated signaling pathway IDA PubMed
interleukin-6-mediated signaling pathway TAS
monocyte chemotaxis IC PubMed
negative regulation of apoptotic process IDA PubMed
negative regulation of bone resorption ISS
negative regulation of cell proliferation TAS PubMed
negative regulation of chemokine biosynthetic process ISS
negative regulation of collagen biosynthetic process IDA PubMed
negative regulation of fat cell differentiation NAS PubMed
Evidence
Component Pubs
Code
endoplasmic reticulum lumen TAS
Evidence
Component Pubs
Code
extracellular region TAS
extracellular space IDA PubMed
interleukin-6 receptor complex IDA PubMed
General protein information
Preferred Names
interleukin-6
Names
B-cell differentiation factor
B-cell stimulatory factor 2
CTL differentiation factor
hybridoma growth factor
interferon beta-2
interleukin BSF-2
NCBI Reference Sequences (RefSeq)
RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
Genomic
1. NG_011640.1 RefSeqGene
Range 4996..9856
Download GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
1. NM_000600.5 → NP_000591.1 interleukin-6 isoform 1 precursor

See identical proteins and their annotated locations for NP_000591.1
Status: REVIEWED
Description Transcript Variant: This variant (1) represents the longer transcript and encodes the
longer isoform (1).
Source sequence(s) AK301141, BC015511
Consensus CDS CCDS5375.1
UniProtKB/Swiss-Prot P05231
UniProtKB/TrEMBL B4DVM1, Q75MH2
Related ENSP00000258743.5, ENST00000258743.10
Conserved Domains (1) summary
pfam00489 IL6; Interleukin-6/G-CSF/MGF family
Location:33 → 211
2. NM_001318095.1 → NP_001305024.1 interleukin-6 isoform 2
Status: REVIEWED
Description Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream
in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-
terminus than isoform 1.
Source sequence(s) CD013918, HY076725
Consensus CDS CCDS83166.1
UniProtKB/TrEMBL B5MC21
cl02473 IL6; Interleukin-6/G-CSF/MGF family
Location:1 → 135
RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109
The following sections contain reference sequences that belong to a specific genome build. Explain
Reference GRCh38.p12 Primary Assembly
Genomic
1. NC_000007.14 Reference GRCh38.p12 Primary Assembly
Range 22725889..22732002
Download GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
1. XM_011515390.2 → XP_011513692.1 interleukin-6 isoform X2

See identical proteins and their annotated locations for XP_011513692.1
UniProtKB/Swiss-Prot P05231
UniProtKB/TrEMBL Q75MH2
pfam00489 IL6; Interleukin-6/G-CSF/MGF family
Location:33 → 211
2. XM_005249745.5 → XP_005249802.1 interleukin-6 isoform X1

See identical proteins and their annotated locations for XP_005249802.1
UniProtKB/TrEMBL B4DNQ5
cl02473 IL6; Interleukin-6/G-CSF/MGF family
Location:87 → 212
Related sequences
Items 1 - 25 of 44 < Prev Page 1 of 2 Next >
Nucleotide
Protein
Heading Accession and Version
genomic AC073072.11 AAS07539.1

genomic AF005485.1 None
Nucleotide
Protein
Heading Accession and Version
genomic AF048692.1 AAC05673.1
genomic AF372214.2 AAK48987.1
genomic AY170325.1 AAN75009.1
genomic CH236948.1 EAL24265.1
genomic CH471073.1 EAW93756.1
EAW93757.1
EAW93758.1
genomic CS352987.1 CAL23031.1
genomic JA104583.1 CCA63961.1
genomic JQ250825.1 AFF18412.1
genomic KX430120.1 AOP17752.1
genomic X04402.1 CAA27990.1
genomic Y00081.1 CAA68278.1
Items 1 - 25 of 44 < Prev Page 1 of 2 Next >
Links
Protein Accession
GenPept Link UniProtKB Link
P05231.1 GenPept UniProtKB/Swiss-Prot:P05231
Additional links
Locus-specific Databases
IL6 database
Gene LinkOut

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27/4/2019 IL6 interleukin 6 [Homo sapiens (human)] - Gene - NCBI

IL6 interleukin 6 [ Homo sapiens (human) ]

See IL6 in Genome Data Viewer

109 current GRCh38.p12 7 NC_000007.14

Genomic regions, transcripts, and products

Go to reference sequence details

Genomic Sequence: NC_000007.14 Chromosome 7 Reference GRCh38.p12 Primary Assembly

Genes, NCBI Homo sapiens Annotation Release 109, 2018-03-27

Biological regions, aggregate, NCBI NCBI Homo sapiens Annotat…

Clinical, dbSNP b152 v2

Live RefSNPs, dbSNP b152 v2

RNA-seq intron features, aggregate (filtered), NCBI Homo sapi…

NC_000007.14: 23M..23M (7.9Kbp)

Project title: HPA RNA-seq normal tissues

See all (4322) citations in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction See all GeneRIFs (3479)

Diabetes mellitus type 1

Inflammatory bowel disease 1

Rheumatoid arthritis, systemic juvenile

NHGRI GWAS Catalog

See variants in ClinVar

Protein Gene Interaction Pubs

Protein Gene Interaction Pubs

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)

Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)

Legionellosis, organism-specific biosystem (from KEGG)

Th17 cell differentiation, organism-specific biosystem (from KEGG)

IL6 interacts with IL6R (IL-6R-

General gene information

Gene Ontology Provided by GOA

cytokine activity NAS PubMed

endoplasmic reticulum lumen TAS

General protein information

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

1. NM_000600.5 → NP_000591.1 interleukin-6 isoform 1 precursor

2. NM_001318095.1 → NP_001305024.1 interleukin-6 isoform 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

Reference GRCh38.p12 Primary Assembly

1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

mRNA and Protein(s)

1. XM_011515390.2 → XP_011513692.1 interleukin-6 isoform X2

2. XM_005249745.5 → XP_005249802.1 interleukin-6 isoform X1

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genomic AC073072.11 AAS07539.1

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P05231.1 GenPept UniProtKB/Swiss-Prot:P05231

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