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Materi 12
Pengantar Mikrobiologi
Bioprocess is a specific process that uses complete
living cells or their components (e.g. bacteria,
enzymes, chloroplasts) to obtain desired products
What is a Bioprocess engineering is the alteration or significance
of renewable thing to create value-added products
Bioprocess A specialization of Biological Engineering,
Engineering Biotechnology, Chemical Engineering or of Agricultural
Engineering
? It deals with the shape or style and development of
equipment and processes for the creation of products
such as pharmaceuticals, food, feed, chemicals, and
many polymers and paper from biological materials
It also deals with studying different biotechnological
processes used in bio industries for large scale
manufacturing of biological product for optimization of
yield and quality in the end product
Bioprocess Engineers work at the frontiers of biological and
What is a engineering sciences to “Bring Engineering to Life” through
the conversion of biological materials into other forms
Bioprocess needed by mankind
Engineering
In other words:
? Usage of engineering principles or terms to analysis of and
development and design of methods using biological
catalysts such as enzymes, living cells and genetically
engineered cells
Bread and beer have been
produced since 2400 BC in Egypt
Did you
know?
In ancient Egypt,
workers recieve beer
as part of their salary
The journey
The journey
• Therapeutic proteins, antibiotics, antibodies,
Biopharmaceuticals polysaccharides, hormones, vaccines and
diagnostic agents
• Alcohols, organic acids, fuels, several chemicals
and fibers from renewable resource
Industrial chemicals • It is an essential component for rapid transition of
& Energy byproducts from the lab to a manufacturing scale
at a reasonable cost
Current • Alcoholic beverages and dairy products, several
novel foods (soya sauce) and musrooms (starch
Bioprocess Food industries and vitamins) and food additives (anti-oxidants)
and value-added products
Technology • Single cell protein, veterinary vaccine and
& Products Agriculture antibiotics, use of nitrogen fixing bacteria, to
produce a transgenic plants and genetic
modifications of foods
The Steps
Scaling up of the process
Down stream
(Separation/Isolation/Purification and incerase of products stability)
Biomass
Enzyme Organisms
feedstock
Example of
food
bioprocessing Pre-treatment Hydrolysis Fermentation Separation Products
Wastewater
Examples
Some applications of submerged bioreactors
Examples
Stirred tank bioreactors
Stirred Tank 15 L
Bioreactors
(STR)
150 L bioreactor
1500 L bioreactor
Bubble column bioreactors
Bubble column
reactor for
algal culture
Airlift Reactors
Airlift
reactors for
plant and
animal cell
culture
Cost values
Plant
factory