Drug

Protocol: Misoprostol

Drug: Misoprostol (Cytotec)
Indication for Use: Prophylaxis or treatment of postpartum hemorrhage.
Mechanism of Action: Synthetic prostaglandin E analogue parent drug that is rapidly deesterified to misoprostol acid
(active metabolite) and replaces protective prostaglandins consumed with therapies that inhibit prostaglandin synthesis;
inhibits gastric acid secretion and protects gastric mucosa. Significantly reduces degree of fat malabsorption in patients
with >10% fat malabsorption, possibly by stimulating duodenal bicarbonate production.

Form Dose Route of Administration instructions Treatment notes

Administration

Capsule 600mcg PO Wash/dry hands. Prophylaxis; give 600mcg, PO,

within one minute of delivery
Explain treatment to client.
Don gloves
Administer capsule, PO to client within
one minute of delivery.
Document medication given, dose, site,
time, and effect

Capsule 800mcg PO Wash/dry hands. Treatment; 800mcg PO once; use

caution if prophylactic dose
Explain treatment to client.
already given and adverse effects
Don gloves present or observed.
Administer capsule, PO to client within
one minute of delivery.
Document medication given, dose, site,
time, and effect

Contraindications: In pregnancy when used to reduce risk of NSAID-induced ulcers. Hypersensitivity to misoprostol,
prostaglandins, or prostaglandin analogues.

Storage: Store at or below 25ºC in a dry area.