Documente Academic
Documente Profesional
Documente Cultură
Syrup oral
GENERIC NAME
160mg/5mL
PARACETAMOL PEDIATRIC
Tablet
BRAND NAME
325mg
TYLENOL® [Johnson & Johnson] 500mg
Dosage and Fequency Caplet
325mg
ADULT 500mg
Tablet 650mg
325mg Capsule
500mg 325mg
Caplet 500mg
325mg Caplet, extended-release
500mg 650mg
650mg Tablet, oral-disintegrating
Capsule 80mg
325mg 160mg
500mg Tablet chewable
Caplet, extended- 80mg
release Solution or suspension, oral
650mg 160mg/5mL
Tablet, oral- Liquid oral
disintegrating 160mg/5mL
80mg
500mg/5mL
160mg
Tablet chewable Syrup oral
80mg 160mg5mL
Solution or suspension, oral NEONATE
160mg/5mL
Liquid oral Solution/suspension [OTC]
160mg/5mL 10–15 mg/kg/dose PO/PR Q6–8 hr
20–25 mg/kg/dose for PO dosing or 30 mg/kg/dose for paracetamol may be due to inhibition of COX-2-dependent
PR dosing pathways that are proceeding at low rates. This hypothesis is
consistent with the similar pharmacological effects of paracetamol
MECHANISM OF ACTION
and the selective COX-2 inhibitors. COX-3, a splice variant of
Paracetamol is a weak inhibitor of PG synthesis of COX-1
COX-1, has been suggested to be the site of action of paracetamol,
and COX-2 in broken cell systems, but, by contrast, therapeutic
but genomic and kinetic analysis indicates that this selective
concentrations of paracetamol inhibit PG synthesis in intact cells in
interaction is unlikely to be clinically relevant. There is considerable
vitro when the levels of the substrate arachidonic acid are low (less
evidence that the analgesic effect of paracetamol is central and is
than about 5 mumol/L). Paracetamol (acetaminophen) is generally
due to activation of descending serotonergic pathways, but its
considered to be a weak inhibitor of the synthesis of prostaglandins
primary site of action may still be inhibition of PG synthesis. The
(PGs). However, the in vivo effects of paracetamol are similar to
action of paracetamol at a molecular level is unclear but could be
those of the selective cyclooxygenase-2 (COX-2) inhibitors.
related to the production of reactive metabolites by the peroxidase
Paracetamol also decreases PG concentrations in vivo, but, unlike
function of COX-2, which could deplete glutathione, a cofactor of
the selective COX-2 inhibitors, paracetamol does not suppress the
enzymes such as PGE synthase.
inflammation of rheumatoid arthritis. It does, however, decrease
swelling after oral surgery in humans and suppresses inflammation INDICATION
in rats and mice. Paracetamol is a weak inhibitor of PG synthesis of
Like other OTC pain relievers, acetaminophen temporarily
COX-1 and COX-2 in broken cell systems, but, by contrast,
relieves minor aches and pains due to headache, backache, the
therapeutic concentrations of paracetamol inhibit PG synthesis in
common cold, minor pain of arthritis, toothache, premenstrual and
intact cells in vitro when the levels of the substrate arachidonic acid
menstrual cramps, and muscular aches, and temporarily reduces
are low (less than about 5 μmol/L). When the levels of arachidonic
fever
acid are low, PGs are synthesized largely by COX-2 in cells that
contain both COX-1 and COX-2. Thus, the apparent selectivity of CONTRAINDICATIONS
Contraindications to the use of acetaminophen include days. Instructed not to use for marked fever (higher than 103.1 F),
hypersensitivity to acetaminophen, severe hepatic impairment, or fever persisting longer than 3 days, or recurrent fever unless it is
severe active hepatic disease. directed by prescriber. Warned that high doses or unsupervised
SIDE EFFECTS long-term use can cause hepatic damage. Excessive ingestion of
Angioedema, Disorientation, Dizziness, Pruritic alcohol may increase the risk of hepatotoxicity.
maculopapular rash, Rash, Hyperammonemia, Stevens-Johnson
syndrome, Toxic epidermal necrolysis, Urticaria, Gastrointestinal
haemorrhage, Laryngeal edema, Agranulocytosis, Leukopenia,
Neutropenia, Pancytopenia, Thrombocytopenia, Thrombocytopenic
purpura, Hepatotoxicity, Liver failure, Nephrotoxicitym,
Pneumonitis, Anaphylactoid
NURSING RESPONSIBILITIES
Safe administration, monitoring for efficacy, and identifying
any possible adverse reactions are, of course, vital nursing
responsibilities for IV use of acetaminophen (or any other
medication). Patient education is also an important nursing function
with all medications.
PATIENT-FAMILY TEACHING
Tylenol is only for short-term use. Consult prescriber if it is
given to children for longer than 5 days or adults for longer than 10
GENERIC NAME BRAND NAME MECHANISM OF ACTION
TRAMADOL HCl TRAMAL [Zuellig] Tramadol acts by binding to μ-opioid receptors on neurons.
Dosage and Frequency It is also a serotonin–norepinephrine reuptake inhibitor (SNRI). It is
ADULT converted in the liver to O-desmethyltramadol, an opioid with
>12 yrs. 50-100 mg 4-6 hrly. Max: 400 mg. Retard tab stronger binding to the μ-opioid receptor.
>12 yrs. Initially, 50-100 mg bid (morning & evening). May be INDICATIONS
titrated ti 150-200 mg bid if pain relief is insufficient. Treatment of moderate to severe pain.
>12 yrs. 50-100 mg 4-6 hrly. Max: 400 mg CONTRAINDICATIONS
PEDIATRIC
Tramadol hydrochloride is contraindicated in any situation
>1 yr. 1-2 mg/kg as a single dose. Max: 8 mg/kg or 400 mg, where opioids are contraindicated, including acute intoxication with
whichever is lower. any of the following: alcohol, hypnotics, and narcotics, centrally
acting analgesics, opioids or psychotropic drugs.
SIDE EFFECTS
Dizziness, headache, drowsiness, nausea and vomiting,
constipation, lack of energy, sweating, and dry mouth
NURSING RESPONSIBILITIES
PATIENT-FAMILY TEACHING’ Dilute required dose to 10ml with normal saline. Inject slowly
onset of pain relief usually occurs within about an hour serious side Compatible with the following IV fluids:
effects may include seizures, increased risk of serotonin syndrome, Normal saline, 5% glucose and sodium chloride
decreased alertness, and drug addiction. A change in dosage may be May be given into the side arm when the above IV fluids are
recommended in those with kidney or liver problems. Its not being infused. Store at room temperature. Protect from light.
Per-orem
Buscopan 10mg (white)
Gastro-Soothe 10mg
(white)
MECHANISM OF ACTION Constipation, dry mouth, trouble urinating, or nausea could
Hyoscine-N-butylbromide (HNBB) acts by interfering with occur. If these continue or are bothersome, notify your doctor
the transmission of nerve impulses by acetylcholine in the promptly. Very unlikely but report: rash, itching, swelling of the
parasympathetic nervous system. hands or feet, trouble breathing, increased pulse, dizziness, diarrhea,
Buscopan exerts a spasmolytic action on the smooth muscle of the vision problems, eye pain.
Do not stop taking this medicine until relief is sought or skin BIOGESIC® [Unilab]
Do not exceed recommended dose. Keep out of reach of children. In strengths. Take care you are giving your child the
centre immediately. Prompt medical attention is critical for adults as Do not exceed the maximum dose recommended
well as for children even if signs or symptoms are not noticed. (four doses in 24 hours)
SIDE EFFECTS Food: can be taken on an empty stomach
low fever with nausea, stomach pain, and loss of appetite; Alcohol: do not drink excessive quantities of
Dark urine, clay-colored stools; alcohol while taking paracetamol
Keep all paracetamol well out of reach of GENERIC NAME
children MULTIVITAMINS + PARACETAMOL
Contact your doctor or seek urgent help if
BRAND NAME
overdose occurs
Paracetamol is an ingredient in a number of
POLYNERV FORTE [Hizon]
medicines for pain, or colds and flu. If taking
paracetamol in one medicine, make sure you Doses and Frequencies
don't take other medicines also containing
paracetamol. ADULT
PO & Rectal: single - 1 g, daily - 4 g.
PEDIATRIC
PO
aged 6-12 years - 250-500 mg
1-5 years - 120-250 mg
RECTAL
6-12 years - 250-500 mg, 1-5
years - 125-250 mg.
MECHANISM OF ACTION ADVERSE EFFECTS
Polynerv Forte is an analgesic-antipyretic. It has Thromboembolism, erythremia, erythrocytosis, increased
analgesic, antipyretic and weak anti-inflammatory action. sensitivity to cyanocobalamin.
The mechanism of action is associated with inhibition of NURSING RESPONSIBILITIES
prostaglandin synthesis, the predominant influence on the BEFORE:
thermoregulation center in the hypothalamus, enhances heat Obtain a sensitivity test before administration
transfer. Avoid I.V administration because of faster systemic
INDICATIONS elimination will reduce effectiveness of vitamin.
Polynerv Forte is used with caution in patients with DURING
disorders of the liver and kidneys, with benign Do not give large doses of vitamin B12 routinely;
hyperbilirubinemia, as well as in elderly patients. drug is lost through excretion.
With prolonged use of Polynerv Forte (Acetaminophen) is Do not mix parenteral preparation in same syringe
necessary to monitor patterns of peripheral blood and with other drugs.
functional state of the liver. AFTER
Used for treatment of premenstrual tension syndrome in Protect vitamin B12from light. Do not refrigerate or
combination with pamabrom (diuretic, a derivative of freeze
xanthine) and mepyramine (Histamine H1-receptors Monitor patient for hypokalemia for first 48 hours,
blocker). as anemia correct itself. Give potassium
CONTRAINDICATIONS supplements, as per needed.
Chronic active alcoholism, increased sensitivity to Polynerv PATIENT-FAMILY TEACHING
Forte, marked disturbances of liver function and / or kidney If you are taking this product under your doctor's direction,
disease, anemia, pregnancy (I term your doctor or pharmacist may already be aware of any possible
drug interactions and may be monitoring you for them. Do not stop, GENERIC
start, or change the dosage of any medicine before checking with
1. IBUPOFEN 200MG, PARACETAMOL 325MG
them first. Before using this product, tell your doctor or pharmacist
of all prescription and nonprescription/herbal products you may use, BRAND
especially of: altretamine, cisplatin, certain antibiotics (e.g., ALAXAN United Lab [Therapharma]
chloramphenicol), certain anti-seizure drugs (e.g., phenytoin),
Dosage and Frequency
levodopa, other vitamin/nutritional supplements.
ADULTS
PEDIATRIC
PO: 1-5 years old: 120mg-250mg every four hours - but no more
than 4 doses per day (24 hours).
Alaxan FR contains the synergistic combination of Diarrhea, nausea, vomiting and pain in the stomach or
ibuprofen and paracetamol in capsule. The inflammatory activity of intestines.
ibuprofen and paracetamol combination is greater compared to the
NURSING RESPONSIBILITIES
individual ingredients. Because pain is usually accompanied by
inflammation, pain relief is more evident when inflammation is Advice the patient to always eat before taking the medication
and always inform themabout the possible side effects.
controlled by ibuprofen. This capsule format allows complete
dissolution of the drugs in at least 10 min, which leads to faster PATIENT FAMILY TEACHING
absorption. Faster absorption. Faster absorption usually leads to
Follow the instructions on the label of the medicine or as
earlier onset of pain relief.
directed by your doctor
INDICATION
Paracetamol for children comes in different strengths. Take
Faster relief of mild to moderately severe pain of care you are giving your child the correct dose
musculoskeletal origin eg muscle pain, arthritis, rheumatism, sprain,
Do not exceed the maximum dose recommended (four doses
strain, bursitis, tendonitis, backache, stiff neck, tension headache,
in 24 hours)
dysmenorrhea, toothache, pain after tooth extraction and minor
surgical operations. Reduction of fever. Food: can be taken on an empty stomach
Naproxen works by reversibly inhibiting both the COX-1 headache, dizziness, drowsiness;
and COX-2 enzymes as a non-selective coxib. This results in the bruising, itching, rash;
inhibition of prostaglandin synthesis. Prostaglandins act as signaling swelling; or.
molecules in the body, inducing inflammation. Thus, by inhibiting ringing in your ears.
COX-1/2, naproxen induces an anti-inflammatory effect.
NURSING RESPONSIBILITIES
INDICATIONS
Advice the patient to always eat before taking the
Naproxen is used to relieve pain from various conditions medication and always inform them about the possible side effects,
such as headache, muscle aches, tendonitis, dental pain, and give them the things to do when they face the side effects.
menstrual cramps. It also reduces pain, swelling, and joint stiffness
caused by arthritis, bursitis, and gout attacks. This medication is
known as a nonsteroidal anti-inflammatory drug (NSAID).
PATIENT FAMILY TEACHING GENERIC NAME
9-10yr -12.5ml
6-8yr 1-0ml
4-5yr -7.5ml
Mechanism. Ibuprofen is a non-selective inhibitor of an upset stomach, mild heartburn, nausea, vomiting;
enzyme called cyclooxygenase (COX), which is required for the
bloating, gas, diarrhea, constipation;
synthesis of prostaglandins via the arachidonic acid pathway. COX
is needed to convert arachidonic acid to prostaglandin H2 (PGH2) dizziness, headache, nervousness;
in the body. This PGH2 is then converted to prostaglandins. mild itching or rash; or.
Advil is used to reduce fever and treat pain or inflammation NURSING RESPONSIBILITIES
caused by many conditions such as headache, toothache,
Assess patient for signs of megaloblastic anemia
back pain, arthritis, menstrual cramps, or minor injury. Advil is used
(fatigue, weakness, dyspnea) prior to and
in adults and children who are at least 6 months old.
periodically throughout therapy.
CONTRAINDICATIONS
PATIENT FAMILY TEACHING
Advil can increase your risk of fatal heart attack or stroke,
Encourage patient to comply with diet recommendations of
especially if you use it long term or take high doses, or if you have
physician or other health care provider. Explain the best
heart disease. Do not use this medicine just before or after heart
source of vitamins is a well-balanced diet with foods from
bypass surgery (coronary artery bypass graft, or CABG). Advil may
the four basic food groups. If physician is trying to diagnose
also cause stomach or intestinal bleeding, which can be fatal. These
folic acid deficiency without concealing pernicious anemia,
conditions can occur without warning while you are using
a diet low in vitamin b12 and folate will be ordered.
ibuprofen, especially in older adults.
Foods high in folic acid include vegetables, fruits and organ
meats; heat destroys folic acid in foods.
Patients self-medicating with vitamin supplements should be GENERIC NAME
cautioned not to exceed RDA. The effectiveness of mega
Diclofenac Na
doses for treatment of various medical conditions is
unproven and may cause side effects. BRAND NAME
Explain the folic acid may make urine more intensely BOIE DICLOFENAC SODIUM
yellow.
Dosage and Frequency
Adult
other NSAIDs, is not completely understood but involves inhibition swelling or pain in your arms or legs.
Diclofenac is used to treat mild to moderate pain, or signs PATIENT FAMILY TEACHING
and symptoms of osteoarthritis or rheumatoid arthritis. Voltaren is
Inform patient that cutaneous flushing and a
also indicated for the treatment of ankylosing spondylitis. The
sensation of warmth, especially in the face, neck and
Cataflam brand of this medicine is also used to treat
ears, itching or tingling and headache may occur
CONTRAINDICATIONS within the first 2hr after taking the drug. These
Patients w/ meningitis not du to an infection and systemic effects are usually transient and subside with
mastocytosis should be extra careful when taking this medicine continued therapy.
bacause the side effects are something really serious and can disrupt Emphasize the importance of follow-up
the patient. examinations to evaluate progress.
Advice patient to make position changes slowly to
SIDE EFFECTS
minimize orthostatic hypotension.
indigestion, gas, stomach pain, nausea, vomiting;
diarrhea, constipation;
headache, dizziness, drowsiness;
GENERIC NAME NEONATE
BRAND NAME <3 mth 10 mg/kg body wt. All doses to be taken tid-qid.
CHILDREN INDICATION
PO: 6-12 yr ½-1 tab. . Fever, headache, muscular aches & pain, toothache, colds,
ear ache, fever due to tonsillectomy, inoculations & vaccinations.
6-12 yr 2-4 tsp,
CONTRAINDICATIONS
1-5 yr 1-2 tsp, 3 mth-1 yr ½-1 tsp.
hypersensitivity to acetaminophen (paracetamol). Patients
Forte syr Childn ≥13 yr 2-3 tsp, with anemia, cardiac, pulmonary, renal and/or liver diseases must
6-12 yr 1-2 tsp, consult first with their physician before taking this drug. These
patients must also avoid prolonged use of acetaminophen
1-5 yr ½-1 tsp.
(paracetamol).
SIDE EFFECTS Alcohol: do not drink excessive quantities of alcohol while
taking paracetamol
Skin rashes and other allergic reactions occur occasionally.
NURSING RESPONSIBILITIES
PATIENT FAMILY TEACHING pain, or colds and flu. If taking paracetamol in one medicine,
make sure you don't take other medicines also containing
Follow the instructions on the label of the medicine or as
paracetamol.
directed by your doctor