List of helpful supplements for starting a detox (in rough order of application)

1. Probiotics (Good to rotate every few days / week, can be phased out when desired, good to take
in conjunction with digestion enzymes)

"Complete Probiotic Formula", from Biotherapy Clinic (San Francisco) – Probably the best base
starting point that I know of, it is wide spectrun with 12 strains and I personally noticed a huge change
in the amount of energy I received from my food when I began rotating this in.
https://www.biotherapystore.com/product.php?productid=114&cat=11&page=1

Ultra Flora Spectrum, from Red Mountain Clinic – A very good overall probiotic worth rotating in.
It is important because it contains saccharomyces boulardii, which is somewhjat unusual but very
important for taking a stand against opportunistic fungus (and maybe other types of microbe?), like
Candida. Red Mountain ships these encased in styrofoam with cool packs.
https://redmountain.metagenics.com/ultraflora-spectrum

Trenev Trio, from Bitherapy Clinic – A high survivability probiotic that contains high concentrations
of only 3 strains. https://www.biotherapystore.com/product.php?productid=56&cat=5&page=2

Note: It's fun to look up bacterial strains and which ones, but it's easy to hit a wall. I'm always looking
for suggestions here; I am certain there are good things out there that I haven't found. As far as I know,
the more varied (so long as they are quality cultures and strains), the better.

1.5.

Intestinal Repair, Barlean's – This is great stuff. Nothing heals the gut lining better than glutamine
except for fasting. The gut lining is replenished in a few days, if no food is taken in. If you feel better
when fasting, you might have leaky gut. It should take a week to replenish itself under more normal
circumstances, without eating carbs or sugars, and with this powder. This also can provide the requisite
glutamine for transitioning into the 'Glutathione phase' later. Can be found at Drug Emporium, or
https://www.barleans.com/products/6.35oz-intestinal-repair-mixed-berry-powder?
sma=sm.00000g5h13m3welg11qysvk4l6dax

2. Digestive Enzymes (I would pretty much always want to take these, personally. Usually these
come from porcine Pancreatin extract [try to find undiluted Pancreatin] or Bromelain [these
seem to often be 'spiked' with things as well, like calcium, so lookout!])

Nutrient Digestion and Absorption, from Vitamin Shoppe – This initiated my weight loss, and I
took them for years. When I began rebuilding my gut flora, I noticed that these had a less-marked
effect. I assume this is because the flora does a lot of this work on a more permanent basis, and when
one takes enzymes they just pass through as a 'single use' scenario. I don't know how good these are
overall and in comparison to others, but an enzyme is an enzyme and I think they are less quality-
dependent than the bacteria. https://www.vitaminshoppe.com/p/digestive-enzymes-90-veggie-caps/vs-
2587

DAO Enzyme – I want to take this and haven't been able to get ahold of it yet. I believe it is very
important for myself, but it specifically adds the DAO enzyme to your gut for the period that it takes to
digest the meal that is eaten immediately following when one swallows the pill. It targets histamine and
ensures that almost NONE of the extra histamine makes it from your food into your body. This can be
very important for some individuals with inflammation or who have mutations in their DAO enzyme
codons. Tell-tale signs of histamine sensitivity include food sensitivities, allergies, chronic respiratory
issues. Histamines are one byproduct of the bacteria that comes in food we get, cooked or otherwise,
particularly meats and cheeses. Also, the longer leftovers are stored, the more histamine one's food
contains. I assume this is especially true with free-range meat that is not treated with antibiotics.
Ingesting this enzme is reportedly VERY effective at eliminating histamine intake from food.

My research about brands of enzymes is not very extensive, but I would take them every day and not
cycle them out like the probiotics if I had access to them.

3. Liver, Kidney and Gall Bladder Support (Can be combined with SNP-specific supplements). It
is important to initialize organ support at this stage of treatment, otherwise one winds up with
circulating toxins.

A1298C mutation support, from HolisticHeal (Amy Yasko, Maine) – I believe this is crucial for
anyone with this mutation, and even without it, the herbs in it are fantastic for liver support for anyone.
I don't believe that this contains and of her RNA formulas, but I could be wrong.
https://www.holisticheal.com/mthfr-a1298c-liver.html

BitterX (Quicksilver Labs, headed by Dr. Shade, probably the leading mind on the body's detox
process) – Bitters is for gall bladder. It works in close connection with the liver and 'blockage' can
happen at a few points there. Refer to Dr. Shade's lectures about this (he began by studying mercury in
wildlife as a molecular biologist). Be aware that if you take this in conjunction with the A1298C
support, you are doubling up on your dandelion root, but I can't imagine that causing any problems.
The Acacia gum in these actually has some startlingly good properties. Xanthan gum is no good btw, as
it reportedly makes sugars and carbs linger in the GI tract for more time than it normally would be
there. https://www.quicksilverscientific.com/bitterx

Choline (as phosphatidylcholine) – Very important to keep things moving in the gall bladder. Eggs
and almonds are good sources, and one can rely on food for this after a month or so. Most people suffer
from degrees of choleostasis, which is a really bad side-symptom of gut and bowel issues.

4. Raw fermented cod liver oil (for long-chain omegas and other things, very complex food, good
to take with enzymes and when the gut flora is being worked on so that full benefit can be
absorbed) – I think Blue Ice is hands-down the best. Their reputation is justified, by my personal
experience, and these initiated a huge change in my body, particularly in circulation, muscle swelling /
tension, and suppleness of muscl tissue. Can be a dramatic feeling but once one adjusts it is very nice.
Adjustment took me about a month, but some major changes started happening on days 1 and 2 of
starting this. I was taking the probiotic from BioTherapy and the enzymes from Vitamin Shoppe at the
time I did this. They undoubtedly 'charged' my absorption. I take this less frequently now (every 2-3
days) but I have no intention of cycling it out. I no longer notice anything dramatic when I take it.

4.5 Start bathing with 4-6 cups of magnesium Chloride in the bath at this stage. I like to spike it
with Magnesium Brine spray oil, it seems to enhance absorption. I will avoid a segue into
electrolyte foundations at this point, but both the magnesium and chloride are vvery important
components. You can get the chloride from salt too, and you can test yourself a bit by drinking salt
water and noting whether the urge to urinate arises quickly. This likely means you needed either the
sodium or the chloride, I think. There is a good book titled 'Transdermal Magnesium' that you could
read if you want to be filled in about this thoroughly. Magnesium is best absorbed through the skin,
though it comes in many forms and each does something kinda different. There's a chart around the
internet somewhere... Avoid Epsom Salts; there is more sulfur than magnesium in them! Best to buy
Mg Chloride flakes, from NOW foods or somewhere else, doesn't really matter.

5. Make your own Glutathione! - There's talk about this liposomal glutathione being really good,
especially from Dr. Shade, but I think that's probably a really rough ride for anyone just beginning their
detox and I wouldn't recommend it right away, if at all (could create a huge load for the liver). Instead,
once your body's 'elimination organs' are sufficiently supported, one can begin trying to boost their
Glutathione levels. Here's how I did that:

Glutathione is built from Glycine, Cysteine, and Glutamine.

Glycine is the one we are generally not getting in the modern diet, as it comes from parts of animals we
don't eat much anymore. The fundament of Glutathione is its sulfur molecule. Refer to the
transsulfuration cycle, and check your GST / GTX SNPs. Also read that 'Dirty Genes' chapter about it.
The body has to be properly cycling its cystiene (to and from homocystiene) in order to not run into a
bottleneck when going to make your own glutathione. This is part of why getting homocystiene levels
checked is important. Muscle knots that just don't want to let go are a decently reliable indicator of
extra unresolved homocystiene.

Complex Cysteines can be derived from food (provided they are absorbed by the gut), however if the
body isn't recycling their end product (homocystiene), then eating lots of sulfur will build up your
homocystiene levels. Making Glutathione is a great way to dispose of excess sulfur, but this requires a
few important co-factors, which I will talk about later.

Glutamine is in plently of foods, and also is in the Barlean's Intestinal Repair. Glutamine and GABA
have an inverse correlation, Glutamine being excitatory and GABA being...relaxatory? A great way to
lower anxiety and panic issues is therefore to use up your body's Glutamine in the production of
Glutathione. Be aware of anxiety / excitement levels when supplementing in glutamine. It can make
one feels wonderfully alert, but can also go 'over the top' into panic. This is why MSG can make
anxiety worse.

Glycine + Collagen, same time (from what I understand, Glycine is absorbed FAR better when
taken with collagen. I experienced this. Can't really explain it.) - I took any old off-the-shelf
Glycine, and I started with this collagen: https://www.vitacost.com/neocell-super-collagen-c which I
got at Wal-Mart. I'm sure there are better out there (let me know!), but avoid Type 2 collagen. Also,
avoid collagen supplements that contain calcium.

Homocysteine-smashing co-factors: Particularly pyridoxal-5-Phosphate (B6) folate (B9) and cobalamin

(B12). Also important to supprt are Riboflavin (B2), Niancin (B3 as Inositol Hexaniacinate –
Important!!), Pantethenic Acid or Pantethene (B5 – Avoid Calcium pantothenate!) More about this and
a higher level diagram here: https://www.foodforthebrain.org/alzheimers-prevention/methylation-and-
homocysteine.aspx

A lesser-known and studied co-factor (for homocysteine) that I think is very important is Serine (best
taken as phosphatidylserine, PS-100 is one of the only usable brands I've found). It works in tandem
with one of the B vitamins (I can't remember, I think B6) as a part of the transsulfuration cycle that
deals with NADP.
Molybdenum is amazing, and helps to clear out many other toxins as well. It is at this stage that you
would want to begin (lightly!) supplementing with Molybdenum, which can be phased out after a
month or two. Molybdenum effective takes homocystiene and 'bounces it' into regular cystiene.
Homocystiene likes to build up in muscle cells, and Molybdenum grabs it and mobilizes it, from what I
understand.

Note: AVOID MSM, unless you are sure. Can be dangerous but that danger isn't well documented.
Also, NAC can be a rough ride, so probably want to avoid this, especially in the beginning. If NAC
turns out to be a good idea (the acetylene part of it can be good)

Sources: Glycine, Glutamine, and phosphatidylcholine can be bought from Thorne labs. I get my
Molybdenum from Thorne as well now, but you may want to start with the Douglas Labs version as it
is a lower dose and easier to break up (pill instead of capsule). This is what I did.

Phosphatidylserine is best bought from Jarrow Formulas (They call it PS-100). It's also Ben Lynch's
recommend and I heartily agree.

The most well-rounded methylated B complex I know of is B-Complex #12 from Thorne, and from
what I understand the Methyguard Plus is a badass version of that, though I am hesitant to try the
stronger ones. Thorne's regular Methylguard is missing some co-factors and is therefore outdated.

Unsweetened Coconut Milk from So Delicious (Oregon): This is surprisingly supportive at this stage,
and the only thing I could use when my detox hit hard. Can be found at most decent stores, I get mine
at natural grocers.

Final Note: Once you have your Glutathione co-factors in, it takes B12 and methyl groups to basically
'kick off' the detoxification effect. It's like the toll that must be paid to use it, once glutathione is getting
effectively 'locked and loaded'.

6. Ultra Binder, from Quicksilver Labs (Catch the toxins and get them out). This was an
annoyingly tricky bit for me before I knew about the Ultra Binder, and one that gave me some real
trouble. I bought everything from activated charcoal to bentonite clay (yea I ate clay, w/e) to get things
moved out. Microsilica turns out to be the best thing for it, and Dr. Shade's formula is so, so good and
by far the most multi-use toxin binder I have seen. If you have high levels of aluminum, use Volvic
water (gotta import it). For most everything else, Ultra Binder is your friend.

Using lots of binder can constipate, so drink lots of water, use George's Aloe Vera (Natural Grocers
carries it, can buy online) to soothe the gut (although the binder actually has aloe in it), and to my
knowledge there doesn't seem to be anything wrong with using Miralax (Polyethylene Glycol) to keep
things going. Avoiding constipation at this stage is quite crucial.

Binder (Occasionally on backorder): https://www.quicksilverscientific.com/ultra-binder

George's Aloe: https://www.warrenlabsaloe.com/liquids.html

7. Introduce thyroid support. This can be done in stages throughout, but the key points here are:

Thyroid hormone is built on Tyrosine. T3 is Tyrosine attached to 3 iodine molecules and T4 is Tyrosine
attached to 4 of them. The thyroid makes T4, and your body 'activates' T4 by removing an iodine
molecule 'on location' in different tissues of the body. This doesn't happen in the thyroid itself so much.
The most crucial enzyme for this is selenomethionine. You must clean up methylation and
transsulfuration for your body to be making adequate methionine on its own (again this is built on a
sulfur molecule), but you can supplement selenomethionine at first (Thorne) and then move to just the
occasional Selenium supplement later. Eggs are good for Selenium. It takes riboflavin to attach the
methionine to the selenum, and intake of iodine uses your available selenium and riboflavin in this way.
Thus, supplementing iodine or eating high iodine foods without getting the necessary selenium with
give you the symptoms of hypothyroidism (and is usually the actual CAUSE of hypothyroid...) by
depleting your selenium. The only place your body metabolizes iodine is in the thyroid, located in the
neck. So, you can expect iodine to have a pretty much immediate effect, if you are deficient, as it goes
right into your thyroid when you swallow. Niacin is also used somewhere in this process, I think. Start
with 100 mcg or less of iodine. It is safe and people are taking megadoses of it right now (like orders of
magnitude more), primarily to literally CREATE more iodine receptors in the thyroid and thus increase
its size / productivity of T4, AND to detox from Bromine (a chemical found on most cardborads),
which has quite a long half life and must be 'dislodged' from the thyroid's iodine receptors by basically
bombarding it with iodine. It's bigger than iodine and is thus invasive to iodine receptors. Anyway, this
is less important but at this stage you'll probably want to be looking at the thyroid a little bit.

That's all I can think of for now... :)