Department of Pharmaceutics, IT-BHU.

M PHARM (2 Yrs) Course Structure

(Applicable to those who admitted from 2007-08 Session)

First Semester
S.No. Subjects Contact Credits
hours/week
1. Departmental Core Subjects (Compulsory for all Streams) [Two
subjects]
PH-5101: Advanced Instrumental Analysis 4 4
PH-5102: Biostatistics & Spectroscopy 3 3
2. Departmental Elective Subjects [Two subjects]
[PH-5103/PH-5111/PH-5112/PH-5121/PH-5122/ 3 3
PH-5131 / PH-5132 / PH-5141 / PH-5142] 3 3
3. Practical
PH-5301: Advanced Instrumental Analysis 6 4
Total of First Semester 19 17

Second Semester
S.No. Subjects Contact Credits
hours/week
1. Open Elective* (From other Departments/Schools) 3 3
2. Departmental Elective Subjects [Four subjects] 3 3
[PH-5201/PH-5202/PH-5211 /PH-5212 / PH-5221 / PH-5222/PH- 3 3
5231/ PH-5232 / PH-5241 / PH-5242] 3 3
3 3
3. Practical / Project
[ PH-5401 / PH-5403 / PH-5405 / PH-5407 ] 6 4
4. Seminar [PH-5402 / PH-5404 / PH-5406 / PH-5408] 2 1
Total of Second Semester 23 20

Third Semester
S.No. Subjects Contact Credits
hours/week
1. Seminar on Dissertation -- 5
[ PH-6301 / PH-6303 / PH-6305 / PH-6307 ]
2. Dissertation – Interim Evaluation -- 5
[ PH-6302 / PH-6304 / PH-6306 / PH-6308 ]
Total of Third Semester -- 10

Fourth Semester
S.No. Subjects Contact Credits
hours/week
1. Dissertation - Open Defense -- 5
[ PH-6401 / PH-6403 / PH-6405 / PH-6407 ]
2. Dissertation – Evaluation -- 10
[ PH-6402 / PH-6404 / PH-6406 / PH-6408 ]
Total of Fourth Semester -- 15

Grand Total of M.Pharm. Course 62

*Open Electives offered by the Departments/Schools:
1. School of Biochemical Engineering, I.T.
2. School of Biomedical Engineering, I.T.
NOTE: Elective subjects offered by the Department of Pharmaceutics, I.T.:
1. PH-5201: Advanced Pharmaceutical Analysis
2. PH-5213: Industrial Pharmacy
3. PH-5223: Drug Design
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 Department of Pharmaceutics, IT-BHU.
M.PHARM. SPECIALIZATION: PHARMACEUTICS

First Semester
S.No. Subjects Contact Credits
hours/week
1. Departmental Core Subjects (Compulsory for all Streams) [Two subjects]
PH-5101: Advanced Instrumental Analysis 4 4
PH-5102: Biostatistics & Spectroscopy 3 3
2. Departmental Elective Subjects [Any Two Subjects]
PH-5103: Computer Application 3 3
PH-5111: Pharmaceutics – I (Advanced Biopharmaceutics) 3 3
PH-5112: Pharmaceutics - II (Pharmacokinetics) 3 3
3. Practical
PH-5301: Advanced Instrumental Analysis 6 4
Total of First Semester 19 17

Second Semester
S.No. Subjects Contact Credits
hours/week
1. Open Elective* (From other Departments/Schools) 3 3
2. Departmental Elective Subjects [Any Four subjects]
PH-5201: Advanced Pharmaceutical Analysis 3 3
PH-5202: Drug Regulatory Affairs 3 3
PH-5211: Pharmaceutics – III (Industrial Pharmacy) 3 3
PH-5212: Pharmaceutics–IV (Advanced Drug Delivery Systems) 3 3
PH-5231: Pharmacology – III (Recent Advances in Pharmacology) 3 3
3. Practical / Project
PH-5401: Pharmaceutics 6 4
4. PH-5402: Seminar 2 1
Total of Second Semester 23 20

Third Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6301: Seminar on Dissertation -- 5
2. PH-6302: Dissertation – Interim Evaluation -- 5
Total of Third Semester -- 10

Fourth Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6401: Dissertation - Open Defense -- 5
2. PH-6402: Dissertation – Evaluation -- 10
Total of Fourth Semester -- 15

Grand Total of Course 62

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 Department of Pharmaceutics, IT-BHU.
M.PHARM. SPECIALIZATION: PHARMACEUTICAL CHEMISTRY

First Semester
S.No. Subjects Contact Credits
hours/week
1. Departmental Core Subjects (Compulsory for all Streams) [Two subjects]
PH-5101: Advanced Instrumental Analysis 4 4
PH-5102: Biostatistics & Spectroscopy 3 3

2. Departmental Elective Subjects [Any Two Subjects]

PH-5103: Computer Application 3 3
PH-5121: Pharmaceutical Chemistry–I(Chemistry of Natural Products) 3 3
PH-5122: Pharmaceutical Chemistry–II(Chemistry of Synthetic Drugs) 3 3
3. Practical
PH-5301: Advanced Instrumental Analysis 6 4
Total of First Semester 19 17

Second Semester
S.No. Subjects Contact Credits
hours/week
1. Open Elective* (From other Departments/Schools) 3 3
2. Departmental Elective Subjects [Any Four subjects]
PH-5201: Advanced Pharmaceutical Analysis 3 3
PH-5202: Drug Regulatory Affairs 3 3
PH-5221: Pharmaceutical Chemistry – III (Medicinal Chemistry) 3 3
PH-5222: Pharmaceutical Chemistry – IV (Drug Design) 3 3
PH-5231: Pharmacology – III (Recent Advances in Pharmacology) 3 3
3. Practical / Project
PH-5403: Pharmaceutical Chemistry 6 4
4. PH-5404: Seminar 2 1
Total of Second Semester 23 20

Third Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6303: Seminar on Dissertation -- 5
2. PH-6304: Dissertation – Interim Evaluation -- 5
Total of Third Semester -- 10

Fourth Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6403: Dissertation - Open Defense -- 5
2. PH-6404: Dissertation – Evaluation -- 10
Total of Fourth Semester -- 15

Grand Total of Course 62

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 Department of Pharmaceutics, IT-BHU.
M.PHARM. SPECIALIZATION: PHARMACOLOGY

First Semester
S.No. Subjects Contact Credits
hours/week
1. Departmental Core Subjects (Compulsory for all Streams) [Two subjects]
PH-5101: Advanced Instrumental Analysis 4 4
PH-5102: Biostatistics & Spectroscopy 3 3
2. Departmental Elective Subjects [Any Two Subjects]
PH-5103: Computer Application 3 3
PH-5131: Pharmacology - I (General Pharmacology) 3 3
PH-5132: Pharmacology - II (Molecular and Clinical Pharmacology) 3 3
3. Practical
PH-5301: Advanced Instrumental Analysis 6 4
Total of First Semester 19 17

Second Semester
S.No. Subjects Contact Credits
hours/week
1. Open Elective* (From other Departments/Schools) 3 3
2. Departmental Elective Subjects [Any Four subjects]
PH-5201: Advanced Pharmaceutical Analysis 3 3
PH-5202: Drug Regulatory Affairs 3 3
PH-5212: Pharmaceutics–IV (Advanced Drug Delivery Systems) 3 3
PH-5231: Pharmacology – III (Recent Advances in Pharmacology) 3 3
PH-5232: Pharmacology – IV (Evaluation of Drug Activities & 3 3
Pharmacometrics)

3. Practical / Project
PH-5405: Pharmacology 6 4
4. PH-5406: Seminar 2 1
Total of Second Semester 23 20

Third Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6305: Seminar on Dissertation -- 5
2. PH-6306: Dissertation – Interim Evaluation -- 5
Total of Third Semester -- 10

Fourth Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6405: Dissertation - Open Defense -- 5
2. PH-6406: Dissertation – Evaluation -- 10
Total of Fourth Semester -- 15

Grand Total of Course 62

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 Department of Pharmaceutics, IT-BHU.
M.PHARM. SPECIALIZATION: PHARMACOGNOSY

First Semester
S.No. Subjects Contact Credits
hours/week
1. Departmental Core Subjects (Compulsory for all Streams) [Two subjects]
PH-5101: Advanced Instrumental Analysis 4 4
PH-5102: Biostatistics & Spectroscopy 3 3
2. Departmental Elective Subjects [Any Two Subjects]
PH-5103: Computer Application 3 3
PH-5141: Pharmacognosy - I (Evaluation of Drugs) 3 3
PH-5142: Pharmacognosy - II (General Pharmacognosy) 3 3
3. Practical
PH-5301: Advanced Instrumental Analysis 6 4
Total of First Semester 19 17

Second Semester
S.No. Subjects Contact Credits
hours/week
1. Open Elective* (From other Departments/Schools) 3 3
2. Departmental Elective Subjects [Any Four subjects]
PH-5201: Advanced Pharmaceutical Analysis 3 3
PH-5202: Drug Regulatory Affairs 3 3
PH-5231: Pharmacology – III (Recent Advances in Pharmacology) 3 3
PH-5241: Pharmacognosy – III (Natural Products) 3 3
PH-5242: Pharmacognosy – IV (Advances in Pharmacognosy) 3 3
3. Practical / Project
PH-5407: Pharmacognosy 6 4
4. PH-5408: Seminar 2 1
Total of Second Semester 23 20

Third Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6307: Seminar on Dissertation -- 5
2. PH-6308: Dissertation – Interim Evaluation -- 5
Total of Third Semester -- 10

Fourth Semester
S.No. Subjects Contact Credits
hours/week
1. PH-6407: Dissertation - Open Defense -- 5
2. PH-6408: Dissertation – Evaluation -- 10
Total of Fourth Semester -- 15

Grand Total of Course 62

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 Department of Pharmaceutics, IT-BHU.
DETAILED SYLLABI

First Semester

Theory
PH-5101: Advanced Instrumental Analysis [Credit: 4]
1. Applications of optical and electrical instruments used in pharmaceutical analysis.
2. Applications of polarography in pharmaceutical analysis.
3. Theory, methods and application of absorption partition, paper, gas chromatography, TLC, PLC, HPLC,
paper electrophoresis and counter current extraction.
4. A comparative study of the advanced physicochemical and chemical methods in analysis of drugs and
pharmaceutical preparations as exemplified by vitamins, antibiotics, glycosides, alkaloids,
sulphonamides, analgesics, antihistamines.

PH-5102: Biostatistics and Spectroscopy [Credits: 3]

1. Biostatistics: Student “t” test, chi Square test, correlation, profit analysis, ANOVA.
2. Spectroscopy: N.M.R., M.S., Optical rotatory dispersion, X-ray diffraction analysis.

PH-5103: Computer Application [Credits: 3]

1. Computer Software: Operating Systems, MS-WINDOWS, General application software. Word
Processors, DBMS, spread sheets, graphics, hardware diagnostics, expert systems, High and low level
programming languages, assemblers, compilers, interpreters.
2. Computer networking. STAR, RING and completely connected networks. LAN and WAN. Internet and
its applications including literature search, E-mail, telemedicine, etc.
3. Structure of a FORTRAN program source code. Brief Introduction of FORTRAN 77. Elementary idea of
program writing in FORTRAN.
4. Subprograms: Subroutines and functions. CALL statements.
5. Exercises illustrating application of various FORTRAN statements to numeric and statistical analysis
mostly related to pharmaceutical sciences.
6. General: management, office automation, statistics and design of experiments (DOE).
7. Pharmaceutical: Pharmacokinetics, stability, bioequivalence, statistical quality control (SQC),
production planning and inventory control (PPIC), validation, QSAR and drug design, drug information
services (DIS), medical diagnosis, design and development of pharmaceutics products through
optimization.

PH-5111: Pharmaceutics – I (Advanced Biopharmaceutics) [Credits: 3]

1. Various aspects of pharmaceutical formulation of different dosage forms.
2. Pre-formulation studies; considerations of powder and liquid, drug materials, their characteristics;
production considerations vis-a-vis the biopharmaceutical aspects of formulations.
3. Biopharmaceutical evaluation of tablets, capsules, liquid orals, parenterals, dermatological.
4. Bioavailability in drug development including bioequivalence studies.
5. Assessment methods of pharmaceutical and therapeutic equivalence; possible reasons for non-
equivalence.
6. Drug interactions.

PH-5112: Pharmaceutics – II (Pharmacokinetics) [Credits: 3]

1. GI absorption of drugs, rate processes and estimation.
2. Volume of distribution, significance and kinetics.
3. Renal and non-renal excretion, clearance kinetics.
4. Compartment modeling.
5. Non-linear kinetics-circadian rhythm and chronopharmacokinetics, other reasons for non-linearity.
6. Ocular kinetics.
7. Physiological determinants of drug clearance.
8. Multiple dosing, doses-loading and maintenance, calculations.
9. Dose adjustment in renal failure, hepatic dysfunction, geriatric and pediatric patients.
10. Therapeutic drug monitoring.
11. Pharmacodynamics, importance and utility in drug therapy.
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 Department of Pharmaceutics, IT-BHU.

PH-5121: Pharmaceutical Chemistry - I (Chemistry of Natural Products) [Credits: 3]

Structure, Stereo-chemistry, Molecular modification and biological activity of natural drug
molecules, belonging to the following classes:
1. Alkaloids: Morphine, Emetine, Reserpine, Ergot.
2. Naturally occurring Anticancer agents.
3. Carotenoids: Carotenes, Xanthophylls.
4. Glycosides and Saponins.
5. Steroids: Male and Female sex hormones (Testosterone, Estradiol). Progesterone, Adrenocorticoids
(Cortisone). Contraceptive agents.
6. Antibiotics: ß-lactam (Cephalosporins), Chemistry of Macrolides (Erythromycin).
7. Chemistry and Biochemical functions of Vitamins A (Retinoids), B6 and B12, C and E. Hormones
(Insulin, Thyroid, Oxytocin).

PH-5122: Pharmaceutical Chemistry - II (Chemistry of Synthetic Drugs) [Credits: 3]

Systematic study, SAR, Mechanism of action and synthesis of the following classes of drugs
included in I.P. and B.P. and U.S.P.), with emphasis on recently introduced drugs.
1. Psychoactive drugs: Major tranquilizers (Phenothiazines, Tricyclic analogs). Antianxiety Agents
(Benzodiazepines).
2. Anticonvulsants: GABA analogs.
3. Anti-histamines: H1 and H2 receptor antagonists.
4. Analgesics: Synthetic and semi-synthetic.
5. Anti-inflammatory: Non-steroidal.
6. Adrenergic and Cholinergic Agents: Cardiovascular and Antihypertensive Agents (Calcium channel
Blockers, ACE inhibitors).
7. Anti-neoplastic agents: Alkyloting agents, Synthesis and mode of action of antimetatolites.
8. Antiviral agents: Anti-HIV agents.

PH-5131: Pharmacology – I (General Pharmacology) [Credits: 3]

1. ADME: Pharmacokinetics, Drug-drug and drug-food interactions.
2. Drug dependence, tolerance, abuse.
3. Drug toxicity.
4. Pharmacogenetics and drug idiosyncrasy.
5. Drug allergy.
6. Drug resistance.

PH-5132: Pharmacology - II (Molecular and Clinical Pharmacology) [Credits: 3]

1. Receptor theories, receptor isolation, radioligand binding studies.
2. Modern concepts of biogenic amine receptors : Catecholamine, Serotonergic, Hisitaminergic and
Dopaminergic & Polypeptics
3. Lipids: Prostaglandines, Prostacycline, Thromboxanes and Leukotrines.
4. Immunopharmacology.
5. Pharmacology of Pain.

PH-5141: Pharmacognosy - I (Evaluation of Drugs) [Credits: 3]

1. Evaluation of drugs: Concepts, considerations, parameters and methods. Quantitative microscopy
and Lycopodium spore analysis (detailed study).
2. Microchemical tests as applied to crude drugs and their chemical constituents, its qualitative and
quantitative aspects.
3. Fluorescence analysis: Qualitative and quantitative aspects, its scope and limitations.
4. Herbal formulations, their standardization and associated complexities (Student will be given a herbal
market preparation with a definite composition and asked to suggest a suitable method of its
standardization/analysis which will be submitted in writing to the concerned teacher).
5. Rational of Selection of Procedure for biological testing of vegetable drugs, activity guided
fractionation.
6. Use of computers in pharmacognosy.

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 Department of Pharmaceutics, IT-BHU.
PH-5142: Pharmacognosy - II (General Pharmacognosy) [Credits: 3]
1. Immunity, Immunomodulation and immunomodulatory drugs of plant origin.
2. Ethanopharmacognosy/Ethanomedicine, its conception, scope and importance.
3. Aromatic plant resources in India; utilization of lignocellulosic waste of essential oil industry; Vanillin
from Sawdust.
4. Comparative phytochemistry, its history, concepts, applications and methods, plant serology and DNA
hybridization.
5. Chemical screening procedures of vegetable drugs of medicinal importance.
6. Microscopy of some important vegetable drugs having anomalous and secretory structures.
7. Principles and procedures of microtome sectioning, staining procedures.
8. Microbial transformation; Aberrant Synthesis.

Practical:

PH-5301: Advanced Instrumental Analysis [Credits: 4]

Second Semester

Theory
Open Elective (From other Departments/Schools): [Credits: 3]

Departmental Elective Subjects:

PH-5201: Advanced Pharmaceutical Analysis [Credits: 3]
QSAR of Anti-tubercular, Anticonvulsant, Anti-inflammatory, Diuretic drugs and Anti-arrythmic drugs.
1. Pharmacological Screening.
2. Methods in quantitative microscopical analysis.
3. Dissolution, Bioavailability evaluation of drugs and formulations, Regulator requirements.

PH-5202: Drug Regulatory Affairs [Credits: 3]

1. Manufacturing: Introduction, regulatory requirements as per Indian and other regulatory authorities
for manufacturing information, formula, process, validation of manufacturing process, equipment,
documentation, inspection requirement, regulatory guidelines for active ingredients and
formulations. Regulatory guidelines for packaging materials, test and evaluation of packaging
materials, biological test, microbiological test and evaluation of closures.
2. Stability testing: Introduction, scientific and technical background to the design of stability testing
regulatory requirements as per Indian and other regulatory authorities for testing of new active
substances, bulk active drug substances, dosage form in their final packaging.
3. Preclinical aspects of biopharmaceutics, clinical bioavailability, study design, presentation
documentation, statistical analysis, current guidelines and developments as per regulatory
requirements of Indian and other regulatory authorities.
4. Clinical pharmacology and Pharmacodynamic: Clinical study design, documentation, presentation and
interpretation. Clinical trials: definition, Phase I, Phase II, Phase III and Phase IV studies, design
documentation, presentation and interpretation, statistical analysis of clinical data, factorial design,
guidelines as per Indian and other regulatory authorities.
5. Intellectual property rights: Introduction, purpose, guidelines as per Indian and other regulatory
authorities.

PH-5211: Pharmaceutics - III (Industrial Pharmacy) [Credits: 3]

1. Principles of improved tablet production system design: Raw materials, Cost efficiency.
2. Tablet Pilot Plant: Designs, Stability features.
3. Large volume Parenterals: Analysis of costs; Operations efficiency management.
4. Production planning and scheduling.
5. Materials handling, operation sequencing.
6. Master Production Records: Format, Flow sheets.
7. Process validation strategies.
8. Raw materials: Establishment of specifications, test procedures, sampling procedures, Assay
validation during product development phase.

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 Department of Pharmaceutics, IT-BHU.
9. Application of ISO criteria to the production of different types of pharmaceutical products.
10. Product validation: Principles; Parameters; Product Fault Detection mechanisms.
11. Special problems of pharmaceutical packaging.

PH-5212: Pharmaceutics - IV (Advanced Drug Delivery Systems) [Credits: 3]

1. Sustained and controlled release principles, dose considerations, physico-chemical and biological
properties of drugs relevant to SR formulations; Regulatory affairs concerned with SR products. Assay
and bio-pharmaceutical evaluation protocols.
2. Effect of system parameters on controlled release drug delivery. Polymers and controlled drug
delivery system development.
3. Oral CDDS: Osmotic, membrane-permeation; pH-control; ion-exchange controlled, controlled gel
diffusion; hydrodynamic pressure controlled systems, matrix systems, floating systems, multi-
laminated systems.
4. Mucosal DDS: Buccal, Nasal, Pulmonary, Rectal and Vaginal DDS, Peptide-based devices.
5. Ocular and Periodontal Systems.
6. Transdermal drug delivery systems.
7. Implants (subdermal).
8. Parental Depot.
9. Disperse systems – Multiple emulsions.
10. Intrauterine Drug Delivery Systems.
11. Targeting of drugs through nanoparticles, liposomes, resealed erythrocytes, monoclonal antibodies,
magnetic microspheres, microspheres, prodrugs, colon targeting.

PH-5221: Pharmaceutical Chemistry - III (Medicinal Chemistry) [Credits: 3]

1. Various Synthetic approaches to modern drugs.
- retro synthetic analysis;
- stereoselective and chemoselective synthesis;
- pericyclic reactions.
2. Mechanism of organic reactions: Carbonium, carbanion, carbene and nitrene.
3. Protaglandin, Thromboxanes and Leukotrienes.
4. Interferons and Gene Therapy.
5. Current topics/Seminars.

PH-5222: Pharmaceutical Chemistry - IV (Drug Design) [Credits: 3]

1. Drug Design: Principles and applications of SAR and PAR (QSAR).
2. Chemical Parameters in Drug Design:
Stereochemistry, Biological isosterism, pro-drugs and analogous.
3. Analog Design.
4. Physicochemical parameters in Drug Design.
5. Study of Artificial Enzymes.
6. Computer-Aided Drug Design (CADD) and Molecular modeling.

PH-5231: Pharmacology - III (Recent advances in Pharmacology) [Credits: 3]

1. Psychopharmacology.
2. Peptides and neurotransmitters.
3. Pharmacology of cyclic nucleotides.
4. Pharmacology of ion channel blockers.
5. Seminars on the topics of current interest.
6. Discussion on current literature.

PH-5232: Pharmacology - IV (Evaluation of drug activities & Pharmacometrics) [Credits: 3]

1. Drug development and evaluation.
2. Screening methods in Pharmacology
3. Recent Experimental methods in Neuropsychopharmacology.
4. Biological standardization.

PH-5241: Pharmacognosy - III (Natural products) [Credits: 3]

1. Methods of investigation of biosynthetic pathway, tracer techniques and autoradiography.

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 Department of Pharmaceutics, IT-BHU.
2. Drug constituents and their biosynthesis:
Alkaloids: Ephedrine, colchicine, hyoscyamine, scopolamine, cocain, nicotine, Quinine,
morphine, codeine, thebain, emetine, strychnine, ergot alkaloids, reserpine,
conissine solasodine, solanidine, aconitine, vincristine and vinblastine.
Glycosides: Digitoxin, Scillaren, Sennosides, barbaloin, prunasin, glycerihizin.
Steroids: Cholesterol, sitosterols, sex-hormones, corticosteroids, hecogenin and
diosgenin.
Coumarin: Umbelliferone, Murrangatin.
Flavones: Rutin, hesperidin, myricetin and morin.
Antibiotics: Penicillin, tetracyclin, cephalosporin, chloramphenicol and griseofulvin.
Vitamin: Vitamin A, D, B1, B2, Nicotinic acid, B12, C and folic acid.
3. Distribution, isolation, purification and detection of the chemical constituents of the following:
Alkaloids: Opium, ergot, cinchona, Raulfia, nux-vomica, vinca, tea, berberis, colchicum,
veratrum.
Glycosides: Digitalis, Senna, Scilla, glycerrhiza.
Carbohydrates: Dextrose, liquid glucose, lactose, mannitol, dextran, methyl cellulose and
pectin.
Oils and fats: Theobrama oil, Lard, lanolin, spermaceti.
Volatile oils: Lemongrass oil, camphor and thyme.
Antibiotics: Penicillin, streptomycin, tetracycline, and erythromycin.
Vitamins: Cynocobalamine.
4. Venom and antivenins, antihaemophilics, fibrinogen and thrombin.

PH-5242: Pharmacognosy - IV (Advances in Pharmacognosy) [Credits: 3]

1. Biotechnology, Mutation, Polyploidy, and hybridization in relation to improvement of vegetable drugs
and their constituents; Chemical races.
2. Plant growth regulators and their use in pharmacognosy, scope and limitations.
3. Anticancer and anti-tumour agents of plant origin.
4. Biologic allergens, hallucinogens, Poisonous plants; plants/plant products used against pest, weed
and rhodent control; plant bitters and sweeteners.
5. Application of Chromatographic techniques in separation and identification of natural products with
special references to alkaloids, steroids, sugars, glycosides, terpenoids, lipids.
6. Tissue culture: History, media, requirements for growth of culture, isolation of organ, tissue
and cells; transfer and maintenance of culture, growth measurement and application of tissue culture
with reference to medicinal plants, its scope and limitations.
7. Antibacterial, antiviral, hepatoprotective and hypoglycemic drugs from Natural origin.
8. Marine products.
9. Recent developments in the field of pharmacognosy, data collected for the preceding five years and
presented as a Seminar.

Practical/Project:
PH-5401: Pharmaceutics / Ph-5403: Pharmaceutical Chemistry/ [Credits: 4]
PH-5405: Pharmacology / Ph-5407: Pharmacognosy

PH-5402 / PH-5404 / PH-5406 / PH-5408: Seminar [Credit: 1]

Third Semester
PH-6301 / PH-6303 / PH-6305 / PH-6307: Seminar on Dissertation [Credits: 5]

PH-6302 / PH-6304 / PH-6306 / PH-6308: Dissertation – Interim Evaluation [Credits: 5]

Fourth Semester
PH-6401 / PH-6403 / PH-6405 / PH-6407: Dissertation – Open Defense [Credits: 5]

PH-6402 / PH-6404 / PH-6406 / PH-6408: Dissertation – Evaluation [Credits: 10]

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 Department of Pharmaceutics, IT-BHU.

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 Department of Pharmaceutics, IT-BHU.
Elective subjects offered by the Department of Pharmaceutics

PH-5201: Advanced Pharmaceutical Analysis [Credits: 3]

QSAR of Anti-tubercular, Anticonvulsant, Anti-inflammatory, Diuretic drugs and Anti-arrythmic drugs.

1. Pharmacological Screening.
2. Methods in quantitative microscopical analysis.
3. Dissolution, Bioavailability evaluation of drugs and formulations, Regulator requirements.

PH-5213: Industrial Pharmacy [Credits: 3]

1. Principles of improved tablet production system design: Raw materials, Cost efficiency.
2. Tablet Pilot Plant: Designs, Stability features.
3. Large volume Parenterals: Analysis of costs; Operations efficiency management.
4. Production planning and scheduling.
5. Materials handling, operation sequencing.
6. Master Production Records: Format, Flow sheets.
7. Process validation strategies.
8. Raw materials: Establishment of specifications, test procedures, sampling procedures, Assay
validation during product development phase.
9. Application of ISO criteria to the production of different types of pharmaceutical products.
10. Product validation: Principles; Parameters; Product Fault Detection mechanisms.
11. Special problems of pharmaceutical packaging.

PH-5223: Drug Design [Credits: 3]

1. Drug Design: Principles and applications of SAR and PAR (QSAR).

2. Development of New Drugs:
The search of lead compounds;
Molecular modification of lead compounds.
3. Chemical Parameters in Drug Design:
Stereochemistry, Biological isosterism, pro-drugs and soft-drugs
4. Analog Design.
5. Physicochemical parameters in Drug Design: Hansch π, Hammett’, σ, Es, MR.
6. Topliss – Decision Tree Approach, Free Wilson, Connectivity and other parameters.
7. Study of Artificial Enzymes.
8. Structure – Based Drug Design.
9. Computer-Aided Drug Design (CADD) and Molecular modeling.

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