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TEST REPORT
PARAMETER RESULT SPECIFICATION
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Disclaimer: If one or more Infectious disease tests are positive (except CMV IgG) or Test not performed, your baby's cord blood unit is suitable for Autologous
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Transplantation only and may not be suitable for Allogenic Transplantation purposes.
* Parameter Not under NABL Scope DR. CHIRAYU PADHIAR, M.B.B.S..: DCP (G25442)
This is electronically generated report.
Senior Medical Director
Frequently Asked Questions - Maternal Blood
A transfusion transmissible infection (TTI) is any infection that is transmissible from person to person through parenteral administration of blood or
blood products. These viruses or bacteria may also be transmitted during organ transplantation, sexual contact, from mother to baby via
placenta (before delivery) or trans-vaginal (at time of delivery) or via breast milk (after delivery). Apart from blood transmission, some infections like
malaria are spread by mosquito bites, specifically Anopheles mosquito.
HIV (HIV I & II antibodies & HIV-I p24antigen), Hepatitis B (HBsAg & Anti HBc), Hepatitis C (Anti HCV), Syphilis, Malaria, Cytomegalovirus (CMV IgG & IgM),
HTLV I & II, NAT
Test methodology:
Initial screening tests involve detection of antigen and/or antibody to a particular virus or bacteria using ELISA/CMIA technology. If the screening tests
are non- reactive, the test result is considered ’negative’ and cord blood unit is considered safe for transplantation. If initial screening test is positive
(except CMV-IgG) the test is repeated in duplicate with a different kit/ platform. If both repeat results are non-‘reactive’, the final interpretation is non-
reactive or negative. If one or both repeat tests are ‘reactive’, further confirmatory testing is performed. For HIV confirmation is done using Western
Blotting. For HCV, confirmation is performed by HCV-NAT technology. If confirmatory test results are positive and the corresponding blood unit is not
permitted for allogeneic transfusion. All infectious disease testing are undertaken in accordance with current regulatory and accreditation
guidelines.
Screening assays are not 100 % accurate. Sometimes test results can be falsely positive or negative. These are not necessarily testing errors but occur due to
inherent limitations in the particular test methodology. Repeat testing at a later date is recommended.
Almost all false-positive test results occur due to cross reactions with other viral or bacterial particles; or in association with medical conditions
such as pregnancy, recent acute illnesses and allergies.
False negative results may be due to antibody levels below the limit of detection of the assay (window period) or lack of antibody reactivity to the
antigens used in this assay.
NAT is a highly sensitive test which detects a particular virus or bacteria even at very low viral/bacterial load for HCV and HIV. As against 11 days of
window period by traditional 4th generation ELISA kits for HIV, window period for NAT is as low as 3 days. False negative results can come even with NAT
testing (if patient has come in the window period of 3 days).
General precautions you need to take in case of positive test result if you test positive for a virus or bacteria:
DO see a doctor for medical evaluation, even if you do not feel sick.
DO consult a doctor about the transmission of infection to your baby through breast milk, as not all infections are transfered through
placenta.
DO use condoms when you have sex and inform your sexual partner.
DO tell anyone with whom you have had sex or shared needles or syringes that you are (and they may be) infected.
DO maximize your chances of remaining in good health by eating a healthful diet, exercising regularly, avoiding stress and getting
adequate rest.
DO NOT DONATE BLOOD, PLASMA, BONE MARROW, ORGANS, SEMEN/SPERM OR BREAST MILK FOR OTHERS.
DO NOT share needles or syringes with anyone.
Cord blood units collected from mothers who test positive for an infectious disease agent (except CMV-IgG) are considered potentially infectious and
quarantined. Such cord blood units can be released only for autologous transplantation and they ar e not released for allogeneic transplantation
i.e. for any other person except the child or mother; unless indicated by ‘Emergency Medical Needs’.
Disclaimer: This fact sheet is for information only and is not meant to be used for self-diagnosis or as a substitute for consultation with a health care
provider. Detailed factsheets can be found on our website. Pls. visit www.lifecell.in. For more information, kindly contact your health care provider.