Acinetobacter baumanni – Resistance Islands

1. AbaR1 Type (AYE) – 86.19kb [Chromosome]

Sl No. Gene/Element Co-ordinates Definition

1 5' partial ATPase 5843..6526
2 Transposase 7362..9272
3 Transposition Helper 9277..10197
4 trkA 12887..14008 putative monooxygenase
5 trxB 14056..15009 thioredoxin reductase
6 arsH 15027..15731 arsenic resistance protein
7 arsB 15737..16780 transmembrane protein of
arsenate pump
8 arsC 16788..17261 arsenate reductase
9 arsR 17268..17600 arsenite inducible
repressor
10 arsR 17646..18146 arsenate reductase
11 uspA 18283..18810 Universal stress protein
12 pbrR 18903..19325 transcription regulator
13 Heavy metal detoxification 19406..20302
protein
14 lspA 20306..20818 lipoprotein signal
peptidase
15 Transposase 20840..22129

16 strA 22279..23115 Streptomycin

phosphotransferase A
17 strB 23106..23951 Streptomycin
phosphotransferase B
18 tnpM 23923..24273 Transposase

19 intI 24212..25225 Integrase

20 dfrI 25382..25855 dihydrofolate reductase

type I
21 qacEdelta1 26559..26906 Quaternary ammonium
compound-resistance protein
22 sulI 26813..27796 sul1delta fusion protein

23 cmlA 28013..29227 chloramphenicol and

florfenicol resistance
protein
24 tetR 29434..30060 Tetracycline repressor
protein
25 tetA 30164..31339 Tetracycline resistance
protein
26 lysR 31360..32085 Transcriptional regulator

27 Transposase-like protein 32177..33709

28 GroEL-integrase fusion 33936..34589

protein

29 aac6 34767..35363 Aminoglycoside 6-

 acetyltransferase
30 recG 35315..37165 ATP-dependent DNA helicase

31 Transposase 37290..38834

32 intI 38973..39626 Integrase

33 IS1999 39751..41001 Insertion sequence

34 bla VEB-1 41135..42034 Betalactamase

35 aadB 42179..42712 Aminoglycoside

adenylyltransferase
36 arr-2 42758..43249 Rifampin ADP-ribosylating
transferase
37 cmlA5 43516..44829 Chloramphenicol resistance
protein
38 bla OXA-10 45094..45894 Oxacillinase

39 aadA1 45872..46702 Aminoglycoside

adenylyltransferase
40 qacEdelta1 46866..47213 Quaternary ammonium
compound-resistance protein
41 sulI 47120..48046 sul1delta fusion protein

42 Transposase ORF513 48451..49992

43 qacEdelta1 50974..51321 Quaternary ammonium

compound-resistance protein
44 sulI 51228..52154 sul1delta fusion protein

45 orf5 52282..52782

46 IS6100 53214..54035 Insertion sequence

47 tnpA 53253..54053 Transposase

48 urf2y 54291..54503

49 merE 54569..54805

50 merD 54802..55200 Mercury operon coregulator

protein
51 merA 55185..56930 Mercuric ion reductase

52 merC 56909..57334 Putative Mercury transport

protein
53 merP 57362..57637 Periplasmic mercuric ion
binding protein
54 merT 57653..58018 Mercuric ion transport
protein
55 merR 58090..58545 Mercury resistance operon
regulatory protein
56 tetR 58957..59634 Tetracycline repressor
protein
57 tetA 59638..60912 Tetracycline resistance
protein
58 pecM 60944..61828 Regulatory protein

59 tnpA 62293..64113 Transposase

60 ybjA 64177..64557
 61 cat 64758..65417 Chloramphenicol
acetyltransferase
62 InsA (Tn1) 65696..65971 Transposase

63 InsB (Tn1) 65890..66408 Transposase

64 IS15 66405..68954 Insertion sequence

65 IS26 69205..69927 Insertion sequence

66 Transposase 69382..72822

67 Resolvase 72933..73592

68 IS15 73481..74131 Insertion sequence

69 IS26 73592..74308 Insertion sequence

70 aphA1 74908..75723 Aminoglycoside

phosphotransferase
71 IS26 75970..76557 Insertion sequence

72 tnpM 76705..77319 Transposase

73 intI 77258..78271 Integrase

74 aac3 78373..78906 Aminoglycoside 3-

acetyltransferase
75 orfX 78878..79537

76 orfX 79410..80075

77 orfX 80091..80396

78 aadDA1 80488..81279 Aminoglycoside 3-

adenylyltransferase
79 qacEdelta1 81443..81790 Quaternary ammonium
compound-resistance protein
80 sulI 81697..82623 sul1delta fusion protein

81 orf5 82751..83251

82 Resolvase N-term 83918..84403

83 Resolvase C-term 84157..84546

84 trbI 85049..85312 Transcriptional regulator

85 pbrR 85434..85856 Transcriptional regulator

86 Heavy metal detoxification 85937..86833

protein
87 lspA 86837..87349 Lipoprotein signal
poeptidase
88 Transposase 87371..88660

89 sulI 89061..90548 sulfate permease

90 3' partial ATPase 92722..93579

2. AbaR2 Type (ACICU) – 16 kb [Chromosome]

Sl No. Gene/Element Co-ordinates Definition

1 aphA1 74908..75723 Aminoglycoside
 phosphotransferase
2 IS26 75970..76557 Insertion Sequence
3 tnpM 76705..77319 Transposase
4 int1 77258..78271 Integrase
5 aacA4 78373..78906 Aminoglycoside 3-
acetyltransferase
6 orfX 78878..79537
7 orfX 79410..80075
8 orfX 80091..80396
9 aadA1 80488..81279 Aminoglycoside 3-
adenyltransferase
10 qacEdelta1 81443-81790 Quarternary ammonium
compound – resistance
protein
11 sul1 81697..82623 Sul1delta fusio protein
12 orf5 82752..83251
13 Resolvase N-term 83918..84403
14 Resolvase C-term 84157..84546
15 trb1 85049..85312
16 pbrR 85434..85856 Transcriptional Regulator
17 Heavy metal 85937..86833
detoxification protein
18 lspA 86837..87349 Lipoprotein signal
peptidase
19 tnpA 87371-88660 Transposase
20 sul1 89061..90548 Sulfate premise
21 Partial ATPase 92722..93579

3. AbaR3 Type (AB0057) – 62kb [Chromosome]

Sl No. Gene/Element Co-ordinates Definition

1 tniC 263613..264323 transposition protein

2 tniA 264324..266234 transposition protein

3 tniB 266239..267159 transposition protein

4 tniD 267189..268304 transposition protein

5 tniE 268297..269745 transposition protein

6 trkA 269849..270916 transposase

7 trxB 271018..271971 transposase

8 arsH 271989..272693 arsenical resistance

protein
9 arsB 272699..273742 Arsenite efflux pump ArsB

10 arsC1 273750..274223 arsenate reductase

11 arsR 274230..274550

12 arsC2 274608..275042 arsenate reductase

13 uspA 275245..275776

14 cadR 275865..276272

15 cadA 276368..276892

16 lspA 277270..277782

17 tnpA 277804..279093 transposase of ISL3 family

18 AB57_04990 279156..279830 AB0057 specific sequence

19 AB57_06250 (topA) 279901..281919 DNA topoisomerase I

20 AB57_04950 (SSB) 281946..282299 single-stranded DNA-

binding protein
21 AB57_06255 283114..283533

22 sul1 283631..284470 Sulfonamide-resistant

dihydropteroate synthase
23 AB57_0267 (orf5) 284598..285098

24 AB57_06265 (transposase) 285605..286369 transposase of IS6100

25 AB57_04990 (Urf2Y) 286607..286819

26 merE 286885..287121

27 merD 287118..287483

28 merA 287501..289186 mercuric ion reductase

29 merC 289225..289650 Mercuric resistance

protein MerC
30 merP 289678..289953 MerP periplasmic mercuric
ion binding protein
31 merT 289969..290334

32 merR 290406..290861

33 tetR(A) 291273..291950 Tetracycline repressor

protein
34 tetA(A) 291954..293228 Tetracycline resistance
protein
35 pecM 293260..294144

36 catA1 294678..296181 Chloramphenicol

acetyltransferase
37 insA 298206..298724 IS1 transposase

38 tnpA 298721..301726 transposase

39 tnpR 301889..302446

40 blaTEM 302629..303489 beta-lactamase

41 tnp26 303560..304276 Tnp26 transposase

42 tnpA 304334..307177

43 tnpR 307288..307947 TnpR resolvase

44 tnp26 307959..308663 transposase of IS26

45 aphA1b 309263..310078 aminoglycoside (3')

phosphotransferase AphA1b
46 tnp26 310208..310912 transposase of IS26
 47 intI1 311484..312518 IntI1 integrase

48 aacC1 312688..313152 aminoglycoside-(3)-

acetyltransferase AacC-A1
or AacC1
49 orfP 313271..313783

50 orfQ 313799..314104

51 aadA1 314196..314987 AadA1 aminoglycoside (3')

(9) adenylyltransferase
52 qacEdelta1 315151..315498

53 sul1 315492..316331 sulfonamide-resistant

dihydropteroate synthase
54 acetyltransferase related 316459..316959
to puromycin
acetyltransferases
55 (AB57_05095) 317267..317611

56 resX 317662..318111 resolvase/invertase

57 trbI 318757..319020 TrbI family protein

58 cadR 319142..319549

59 cadA 319645..320541

60 lspA 320545..321057 lipoprotein signal

peptidase
61 tnpA 321079..322368 transposase of ISL3 family

62 sup 322769..324256 sulphate permease

63 orf4 324551..326347

64 ATPase 326430..327287

4. AbaR4 Type (Ab0057) – 16 kb [Chromosome]

Sl No. Gene/Element Co-ordinates Definition

1 transposon 582113..598924

3 Tn2006 584349..589153 transposon

4 tnpAba1 584367..584801 transposase of ISAba1

5 tnpAba1 584888..585457 transposase of ISAba1

6 bla-OXA-23 585563..586384 class D beta-lactamase

9 ISAba1 587974..589153 insertion sequence

10 tnpAba1 588045..588614 transposase of ISAba1

11 tnpAba1 588701..589135 transposase of ISAba1

12 sup 589139..590605

13 Tn6022 589154..598924 transposon

14 uspA 590618..591469 Universal stress protein

family protein
17 tniE 592655..594085 transposition protein

18 tniD 594078..595193 transposition protein

 19 tniB 595223..596143 TniB transposase

20 tniA 596148..598058 TniA transposase

21 tniC 598059..598769 transposition protein

5. AbaR4 Type (D36) -16 kb [Chromosome]

Sl No. Gene/Element Co-ordinates Definition

1 transposon 41312..58123

2 Tn6022 41312..51082,55897 transposon

..58123
3 Inverted repeats 41312..41337

4 tniC 41419..42177 transposition protein

5 tniA 42178..44088 TniA transposase

6 tniB 44093..45013 TniB transposition protein

7 tniD 45016..46158 transposition protein

8 tniE 46136..47581 transposition protein

9 ORF 47956..48327

10 uspA 48767..49618 universal stress protein A

11 sup 49631..51097

12 Tn2006 51083..55887 transposon

13 ISAba1 51083..52262 insertion sequence

19 Bla OXA-23 class D beta-lactamase

OXA-23
20 ISAba1 53852..54673 insertion sequence

21 transposition protein 55423..55869

22 ORF4 56227..58023

23 IRr of AbaR4 58098..58123

6. AbaR4 Type (A85) – 16 kb [Plasmid]

Sl No. Gene/Element Co-ordinates Definition

1 IRl of AbaR4 39243..39268

2 tniC 39398..40108 transposition protein

3 tniA 40109..42019 TniA transposase

4 tniB 42024..42944 TniB transposase

5 tniD 42947..44089 transposition protein

6 tniE 44067..45512 transposition protein

7 uspA 46698..47543 universal stress protein A

8 sup 47556..49022 sulphate permease

9 Tn2006 49008..53812 transposon

 10 ISAba1 49008..50187 insertion sequence

11 bla OXA-23 51777..52598 class D beta-lactamase

OXA-23
12 ISAba1 52633..53812 insertion sequence

15 transposition protein 53348..53794

16 orf4 54152..55948

17 IRr of AbaR4 56023..56048

7. Abar4a Type (LT-3) – 18 kb [Chromosome]

Sl No. Gene/Element Co-ordinates Definition

1 orf1 418..1128

2 tniA 1129..3039 transposase

3 tniB 3044..>3544

4 orf3 <3545..3682

5 uspA 4868..5719 universal stress protein

6 sup 5732..7219 sulfate permease

7 orf4 7514..9310

8 tetA(B) 9393..10658 tetracycline resistance

protein
9 tetR 10689..11315 repression protein

10 transcription regulator 11293..11697

Ars-R family
11 ISCR2 11700..13547 insertion sequence

12 tnpA of ISCR2 11935..13428 transposase

13 strB 13983..14828 streptomycin resistance

protein
14 strA 14819..15622 streptomycin resistance
protein
15 orf5 16005..17792

8. AbaR4b Type (LT-11) – 21 kb [Chromosome]

*partial

Sl No. Gene/Element Co-ordinates Definition

1 Tn2006 29..4833 transposon

2 ISAba1 29..1208 insertion sequence

3 tnpB 47..493 transposase subunit

 4 tnpA 568..1137 transposase 1

5 DNA methylase 1179..1571

6 helicase 1579..2133

7 ATPase superfamily <2031..2693

8 bla(Oxa-23) 2798..3631 carbapenemase

9 ISAba1 3654..4833 insertion sequence

10 tnpA 3725..4294 transposase 1

11 tnpB 4369..4815 transposase subunit

12 sup <4834..>4878 sulfate permease

13 orf4 5173..6969

9. AbaR4c Type (LT-V1) – 23 kb [Chromosome]

*Partial

Sl No. Gene/Element Co-ordinates Definition

1 tniA <1..113 transposase

2 tniB 118..1038 transposase

3 orf2 1041..2183

4 orf3 2692..3606

10. AbaR5 Type (3208) – 56 kb [Chromosome]

Sl No. Gene/Element Co-ordinates Definition

1 IR of AbaR5 27587..27611

2 TniC/ formerly orf1 27694..28452

3 tniA 28453..30363 TniA transposase

4 tniB 30368..31288

5 tniD 31291..32433 transposition protein

6 tniE 32411..33874 transposition protein

7 trkA 33978..35102

8 trxB 35147..36100

9 arsH 36118..36822 arsenical resistance

protein
10 arsB 36828..37871 arsenical resistance
protein

11 arsC 37879..38352 arsenate reductase

12 arsR 38359..38691 arsenical resistance

operon repressor
13 arsC 38737..39237 arsenate reductase

14 uspA 39374..39897, *interrupted by the

79877..80204 insertion of MARR
15 Tn6018-L 39906..43278 transposon
16 IRl of Tn6018-L 39906..39929 inverted repeats

17 cadR 39994..40401 MerR family

transcriptional regulator
18 cadA 40497..41393 Co/Zn/Cd efflux system
component
19 lspA 41397..41909 lipoprotein signal
peptidase
20 tnpA 41931..43220 transposase of ISL3 family

21 IRr of Tn6018-L 43255..43278

22 top 44029..46047 DNA topoisomerase I

23 sul1 47759..48598 sulfonamide-resistant

dihydropteroate synthase
24 orf5 48726..49226

25 IRt 49549..49573 Inverted repeats

26 IS6100 49672..50551 insertion sequence

27 tnpA6100 49733..50497 transposase

28 IRr of IS6100 50538..50551 Inverted repaeats

29 IRt 50552..50703 similar to IRt end of

Tn402 tni module
30 IRt 50552..50703 right hand inverted repeat
of class 1 integron
31 urf2Y 50735..50947

32 merE 51013..51249

33 merD 51246..51611

34 merA 51629..53314 MerA Hg(II) mercuric ion

reductase
35 merC 53353..53778 MerC transmembrane protein

36 merP 53806..54081 MerP periplasmic mercuric

ion binding protein
37 merT 54097..54462 MerT mercuric ion
transport protein
38 merR 54534..54989 MerR activator/repressor
of mer operon
39 IRmer 54985..55021 Inverted repeats

40 IRRI 55066..55102 Inverted repeats

41 tetR(A) 55401..56078 repressor protein

42 tetA(A) 56082..57356 confers resistance to

tetracycline
43 pecM 57388..58272

44 IS26 60311..61130 insertion sequence

45 IRr of IS26 60311..60324 Inverted repeats

46 tnpA26 60363..61079 transposase of IS26

47 IRl of IS26 61117..61130 Inverted repeats

48 tnpA 61137..63980 transposase

49 IR 63979..64013 Inverted repeats

50 tnpR 64091..64750 TnpR resolvase

51 Tn6020 64699..67767 transposon

52 IS26 64699..65518 insertion sequence

53 tnpA26 64762..65466 transposase of IS26

54 IRr of IS26 65505..65518 Inverted repeats

55 IS26 <65519..65641 insertion sequence

56 IRr of IS26 delta 65680..65693 Inverted repeats

57 aphA1b 66066..66881 aminoglycoside (3')

phosphotransferase AphA1
58 IS26 66948..67767 insertion sequence

59 IRl of IS26 66948..66961 Inverted repeats

60 tnpA26 67011..67715 transposase of IS26

61 IRr of IS26 67754..67767 Inverted repeats

62 class 1 integron 68214..74479

63 IRi 68214..68238 left hand inverted repeat

64 intI1 68416..69429 IntI1 integrase

65 aacC1/aacCA1 69531..70064 aminoglycoside-(3)-

acetyltransferase AacC-A1
or AacC1
66 aacC1/aacCA1 69600..70064 aminoglycoside-(3)-
acetyltransferase AacC1 or
AacC-A1 or AAC-(3)-Ia
67 orfP 70183..70695

68 orfP 70721..71233

69 orfQ 71249..71554

70 aadA1 71646..72437 AadA1 aminoglycoside (3')

(9)
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