Humalyzer Primus Service Manual

HumaLyzer Primus
| Service Manual
|
Cat.No. 18200/200
REVISION HISTORY
No. Rev. / Date. Revision Description
1 01/2010-07 First edition
SYSTEM VERSION
HumaLyzer Primus with software version 2.5e
COPYRIGHT
Copyright 2010, Human GmbH, Wiesbaden, Germany. All rights reserved.
No part of this documentation may be reproduced in any form, nor processed,
copied or distributed by means of electronic systems, without prior permission
of Human GmbH in writing. Since all precautionary measures were taken into
account in producing these operating instructions, the manufacturer accepts no
responsibility for any errors or omissions. This includes any liability for damage
that could arise from possible incorrect operation based on this information.
Subject to changes without notice as result of technical development.
SERVICE UND SUPPORT

Contents
1 Safety Instructions 5
1.1 User Warranty 5
1.2 Intended Use of the Instrument 5
1.3 General Safety Warnings 6
1.4 Disposal Management Concept 6
1.5 Biohazard Warning 7
1.6 Instrument Disinfection 7
1.7 Notice 8
2 System Description 10
2.1 Unpacking 10
2.2 Product Features 10
2.3 Product Structure and Composition 10
2.4 Installation 11
2.4.1 Selecting a proper location for the instrument 11
2.4.2 Power supply requirement 11
2.4.3 Connecting the instrument to power supply 12
2.4.4 Installing the flow cell 13
2.5 Main Structure 14
2.5.1 Front view 14
2.5.2 Keypad 15
2.5.3 Back view 16
2.5.4 Internal Printer 16
2.5.5 Flow Cell and Cuvette 17
2.5.6 Lamp and peristaltic pump 19
2.5.7 Schematic System Diagram (for reference only) 20
2.6 Specifications 21
2
3 Functions 22
3.1 Function block diagram 22
3.2 Functional description of the power supply 22
3.3 Rear board functions 23
3.3.1 Functional description of the rear board 23
3.3.2 Function block diagram of the back board 23
3.3.3 Principle description of the rear board 24
3.4 Front board functions 25
3.4.1 Description of front board functions 25
3.4.2 Principle block diagram of front board 25
3.4.3 Controlling of choosing spectral filter 26
3.4.4 Control over liquid-intake
intake of the peristaltic pump 26
3.4.5 Detection and controlling of temperature 26
3.4.6 Sampling and transformation of light energy 26
3.4.7 Control of the tungsten halogen lamp 26
3.5 Functional description of the pipeline 27
3.5.1 Functional Specifications 27
3.5.2 Structure of the pipeline 27
3.6 Functional description of the optical path 27
3.6.1 Functional Specifications 27
3.6.2 Structure of optical path 29
4 Replacement of modules 31
4.1 Disassembling of the analyzer 31
4.2 Replacement of lamp 34
4.3 Replacement of switch 35
4.4 Replacement of spectral filter 37
4.5 Replacement of signal receiving board 41
4.6 Replacement of pipelines 42
5 Regular maintenance 44
5.1 Summary 44
5.2 Cleaning the analyzer 44
5.2.1 Cleaning the surface of the analyzer 44
5.2.2 Cleaning the cell 44
HumaLyzer Primus | Service manual

3
5.2.3 Cleaning
eaning the outside of the cell. 44
5.2.4 Cleaning the inside of the cell 44
6 Problem-solving
solving guide line 46
6.1 Fix pump tube 46
6.2 Change the chip 47
6.3 Optical setting instructions 48
6.4 Change the input voltage between 110V and 220V 49
4

5
1 SAFETY INSTRUCTIONS
This manual is considered part of the instrument and must be available to the
operator and the maintenance personnel.
personnel For accurate installation, use and
maintenance, please read the following instructions carefully. In order to avoid
damage to the instrument or personal injury,
injury carefully read the ”GENERAL
SAFETY WARNINGS” describing the appropriate operating procedures. Please
contact the local Technical Service in the event of instrument failure or other
difficulties with the instrument.
1.1 User Warranty

HUMAN warrants that instruments sold by one of its authorised representatives
shall be free of any defect in material or workmanship, provided that this
warranty shall apply only to defects which become apparent within one year
from the date of delivery of the new instrument to the purchaser.
The HUMAN representative shall replace or repair any defective item at no
charge, except for transportation expenses to the point of repair.
This warranty excludes the HUMAN representative from liability to replace any
item considered as expendable in the course of normal usage, e.g.: lamps, valves,
syringes, glassware, fuses, diskettes,
diskettes tubing etc.
The HUMAN representative shall be relieved of any liability under this warranty
if the product is not used in accordance with the manufacturer's instructions,
altered in any way not specified by HUMAN, not regularly maintained, used with
equipment
pment not approved by HUMAN or used for purposes for which it was not
designed.
HUMAN shall be relieved of any obligation under this warranty, unless a
completed installation / warranty registration form is received by HUMAN
within 15 days of installation of this product.
This warranty does not apply to damages incurred in shipment of goods. Any
damage so incurred shall be reported to the freight carrier for settlement or
claim.
1.2 Intended Use of the Instrument

The instrument must be used for its intended purpose (see paragraph 2). It must
be operated in perfect technical conditions by qualified personnel in such
working conditions and maintained as described in this manual in the GENERAL
SAFETY WARNINGS. This manual contains instructions for qualified professional
operators.
6
1.3 General Safety Warnings

Use only chemical reagents and accessories specified and supplied by HUMAN
and/or mentioned in this manual.
Place the product so that it has proper ventilation.
The instrument should be installed on a flat,
f stationary working surface that is
free of vibrations.
Do not operate in area with excessive dust.
Operate at temperature and at a humidity level in accordance with the
specifications listed in this manual (chapter 7.1).
Do not operate this instrument with covers and panels removed.
Use only the power cord specified for this product, with the grounding conductor
of the power cord connected to earth ground.
Use only the fuse type and rating specified by the manufacturer for this
instrument The use of fuses
instrument. uses with improper ratings may pose electrical and fire
hazards.
To avoid fire or shock hazard, observe all ratings and markings on the
instrument.
Do not power the instrument in environments that are potentially explosive or
at risk of fire.
Prior to cleaning
clea and/or performing maintenance on the instrument, switch off
the instrument and remove the power cord.
Only
nly cleaning materials described in this manual may be used, as other
materials may damage parts.
It is recommended to always wear protective apparell and eye protection while
using this instrument.
All warning
arning symbols that appear in this manual must be carefully observed.
1.4 Disposal Management Concept

The applicable local regulations governing disposal must be observed. It is the
user’s responsibility to arrange for the proper disposal of the individual
components.
All parts which may contain potentially infectious materials must be disinfected
by suitable,
suitable validated procedures (autoclaving, chemical treatment) prior to
disposal. Applicable local regulations
regulat for disposal must be carefully observed.
The instruments and electronic accessories (without batteries, power packs etc.)
must be disposed of according to the regulations for the disposal of electronic
components.
Batteries, power packs and similar power po sources must be removed from
electric/electronic parts and disposed of in accordance with applicable local
regulations.

7
1.5 Biohazard Warning

Analytical instruments for in vitro diagnostic application involve the handling of
human samples and controls whichwhic should be considered at least potentially
infectious. Therefore every part and accessory of the respective instrument
which may have come into contact with such samples must equally be
considered as potentially infectious.
1.5 Biohazard
1.5-1:
The „BIOHAZARD“ warning label must be affixed to instrument prior to first use
with biological material !
1.6 Instrument Disinfection

Instruments or parts which may come in contact with biological samples
(patient
patient specimens, controls etc.) should be considered at least potentially
infectious.
Before performing any service work on the instrument, it is very important to
thoroughly disinfect all possibly contaminated parts. Before the instrument is
removed from m the laboratory for disposal or servicing, it must be
decontaminated / disinfected. Decontamination/disinfection must be
performed by authorised, well trained personnel and in observance of all
necessary safety precautions. Instruments to be returned must be accompanied
by a disinfection certificate completed by the responsible laboratory manager. If
a disinfection certificate is not supplied, the returning laboratory will be
responsible for charges resulting from non-acceptance
non of the instrument by the
servicing centre or from intervention by governmental authorities.
8
1.7 Notice
Every effort has been made to avoid errors in text and diagrams
diagrams. HUMAN,
however, assumes no responsibility for any errors which may appear in this
publication. It is the policy of HUMAN to improve products as new techniques
and components become available. HUMAN therefore reserve reserves the right to
change specifications if necessary in the course of such improvements.
Warning: Warning indications must be obeyed in order to ensure the

normal operation of instruments and correct and accurate test
results. Boldface is used to indicate warnings.
Warning and Safety Indications

This instrument is only used for in vitro diagnosis. Please carefully read the
following warnings before usage and strictly obey them.
Warning: Please carefully read the following instructions before using this
instrument.
Immediately turn off the power supply and pull the power plug from the outlet
if there is an abnormal smell or smoke. You must then immediately consult the
distributor for recommendations about appropriate tests tests. The instrument may
cause fire, electric shock or personal injury if it is used continuously in such a
condition.
Neither blood, reagent nor metal pieces from staples or pins may be dropped
into the instrument, as this may cause a short circuit, smoke or fire. In the event
of abnormal malfunction, immediately turn off the power supply and pull the
power
ower plug from the outlet. You must then immediately consult the distributor
for recommendations about appropriate tests.
Operators may not touch the electric circuit inside the instrument, especially
with wet hands (due to the increased risk of electric shock).
Rubber gloves must be worn while performing maintenance and inspecting the
instrument. The proper tools and spare parts must be used. After finishing the
maintenance or inspection, please wash your hands using disinfectant liquid
soap. Otherwise, skin
skin which has come into contact with blood may be exposed
to infection, electrical injury and burns.

9
Reagent application
 If the reagent contacts your eyes, flush your eyes immediately using large
quantities of water and get medical help.
 If the reagent is accidently consumed (drunk), get medical help immediately
and drink large quantities of water to induce vomiting.
 If your hand or skin is stained by the reagent, flush immediately with water.
 Tubes and other instruments must be properly disposed of as medical
med waste
or infectious waste after use. Contact with blood presents a risk of infection
by pathogens.
Electrical voltage, connection and earthing
 Ensure that the plug is not inserted into an AC electrical outlet with voltage
greater than 110/220 VAC AC ± 10%.
10 Otherwise, it may cause fire or electrical
shock.
 The machine must be installed using the included three-pin
three power cable.
Ensure that it is well earthed. Otherwise, it may cause fire or electrical shock.
 Be sure not to damage the protective insulation on the power cable. Do not
pull strongly on the power cable or hang heavy items off it. Otherwise, it may
cause a broken circuit or a short circuit, which may cause electrical shock or
fire.
 The power supply must be disconnected when connecting peripheral
equipment. Otherwise, it may cause electrical shock or malfunctions.
malfunctions
Note: To change the internal power supply of the instrument to be

used with 110V AC power supply, please revert to the
corresponding information in this Service Manual.
This change shall only be performed by a HUMAN GmbH trained service

engineer.
10
2 SYSTEM DESCRIPTION
The product is intended for the in vitro diagnostic [IVD] clinical testing of serum,
plasma, urine and CSF samples.
The HumaLyzer
H Primus is a semi-automated Chemistry Analyzer
Analyzer.
2.1 Unpacking
Remove all the parts from their package.
When unpacking the instrument, please make sure that the following items are
contained in the packing. In case of damage or missing item, please cont
contact the
supplier immediately.
HumaLyzer Primus 1 [REF]:18200
Flow Cell 1 [REF]:18200/15
User Manual 1 [REF]:18200/100
Power Cord 1 [REF]:18200/75
Spare Fuse 2 [REF]:18200/41
Aspiration Tube 1 [REF]:18200/18
Pump Tube 1 [REF]:18200/19
Lamp 1 [REF]:18200/13
Dust Cover 1 [REF]:18200/80
Waste Bottle 1 [REF]:18200/81
2.2 Product Features

 Monochrome LCD, English menu (Spanish and Russian on request).
 Two test modes for single wavelength and double wavelength.
 The following test methods are available:
End
End-point
Fixed
Fixed-time
Kinetic
Bichromatic
Absorbance
Multi
Multi-point calibration
 It can perform sample analysis of serum, plasma, whole blood and urine.
 Compatible with reagents without any specific restrictions.
 Internal printer can print reports and programming
programming parameters, etc.
2.3 Product Structure and Composition

The product is composed of an optical system, a sipper system, a computer
control system and software.
software

11
2.4 Installation
2.4.1 SELECTING A PROPER LOCATION FOR FO THE INSTRUMENT

Find a place that is not exposed to direct sunshine. The surface of the selected
installation location should be flat and provide sufficient space to accommodate
the HumaLyzer Primus. The front edge of the instrument should be near the
edge of the working table. Avoid significant vibrations on the working table (for
example, do not place a centrifuge on the working table).
Note: The temperature of the instrument’s operating environment

must be between 10…30°C with a relative humidity below 70%.
In order to ensure proper functioning of the instrument, it may not be placed in

the following areas:
 Areas subject to extreme temperature changes
 Very hot or cold areas
 Very dusty areas
 Areas near electromagnetic devices that produce a magnetic field
 Areas exposed d to direct sunshine
2.4.2 POWER SUPPLY REQUIREMENT

MENT
 110/220Vac ±10%
 50/60±1 Hz
 80VA
12
2.4.3 CONNECTING THE INSTRUMENTUMENT TO POWER SUPPLSUPPLY

1. Insert one end of the power cable into the instrument’s power plug.
2. Insert the other end of the power cable into the power supply’s out
outlet.
Warning:
AC power must be well earthed (near-ground voltage <5V).
The AC power supply must be stable. High-power

power equipment may not be used
on the same power supply. A voltage-regulated
regulated power supply is preferable.
In areas with unstable voltage, please use a UPS power supply to ensure proper
functioning of the instrument.
When removing the power cable, pull on the plug instead

stead of on the power
cable.
In the event that smoke, abnormal smell or unusual sound emanate from the
instrument, immediately switch
witch off the power and contact the distributor.

13
2.4.4 INSTALLING THE FLOW CELL

Open the cover of the light source as shown in the following figure 2.4.4-1.
2.4.4-1: Opening the lamp cover
1. Remove the adhesive tape used to secure the flow cell.

2. Remove the wrapping materials.
3. Place the flow cell into thermostatic bath.
4. Carefully insert the flow cell. Run the aspiration tube through the fixing hole
on the machine;; allow it to extend a few centimetres.
5. Close the lamp cover.
Warning:
Do not touch the surface of the light inlet window on the flow cell by hand to
avoid transferring grease from your hands onto the window, which will affect
transmittance.
Ensure that the aspiration tube is in the socket. Otherwise,

Other it will cause
pressure build-up
up and bend, which will affect the test results. This can easily
cause significant bubble formation and increase the water blank.
14
2.5 Main Structure

This part presents the structure of all major components of the HumaLyzer
Primus
rimus.
2.5.1 FRONT VIEW
2.5.1--1: Front view
1. Printer cover 5. Keypad

2. Lamp cover 6. Power supply indicator light
3. Aspiration tube 7. LCD
4. Aspiration key

15
2.5.2 KEYPAD
2.5.2-1: Keypad
Direction keys: Move the cursor in four directions on the

screen: up, down, left and right.
Paper feed key: Manually feed paper; is also the shortcut key
for parameter printing.
Rinse key: Clean the pipeline.
Exit key: Exit the menu and cancel the operation.
Enter key: Confirm the input and save.

16
2.5.3 BACK VIEW
2.5.3--1: Back view
1) Parallel port for printer (not used) 6) Fuse
2) RS-232 serial port 7) AC input
3) RS-232 serial port 8) Fan
4) Drain port 9) Backplate label
5) Power switch 10) Peristaltic pump
2.5.4 INTERNAL PRINTER

HumaLyzer Primus has a built-in thermal printer.

17
2.5.5 FLOW CELL AND CUVETTE

1. Open the lamp cover as shown in the following figure 2.5.5-1.
2.5.5-1: Opening the lamp cover
Note: To open the light source cover, first press the knobs on both
sides of the cover firmly inward and ensure that they recess,
then open the cover in the direction shown in the figure above.
18
2. Internal components of the colorimetric system
2.5.5--2: Internal components of the colorimetric system
 Thermostatic bath
 Flow cell
3. Using the cuvette system

 Remove flow cell from thermostatic bath.
 Place the cuvette with samples into the thermostatic bath.
 All test methods are the same as those in a test using the flow cell system.

19
2.5.6 LAMP AND PERISTALTIC PUMP

1. Open the lamp cover.
2. When changing the lamp, remove the connecting line for the lamp bracket
and power supply, unscrew the fixing screws on the lamp bracket, remove
the lamp bracket, replace the old lamp with a new one and place it in the
same position, then tightly screw in the tightening screws on the lamp
bracket. Reconnect the connecting line for the light bracket and the power
supply firmly.
3. Lamp and peristaltic pump as shown in the following figure:
2.5.6-1: Light source system

20
2.5.6--2: Peristaltic pump system
2.5.7 SCHEMATIC SYSTEM DIAGRAM (FOR REFERENCE ONLY)
2.5.7--1: Schematic system diagram

21
2.6 Specifications
Linear range: 0.000-2.500A
0.000
Resolution: 0.001Abs (Display), 0.0001 Abs (Internal
calculation)
Light source: Tungsten halogen lamp, 6V/10W, the life-span
life is
2000 hours
Wavelength: 340nm, 405nm, 500nm, 546nm, 620nm, two
other wavelength can be added.
Drift: 0.005A/1h
Temperature control: Room temperature, 25, 30, 37°C (Peltier
component), precision is ±0.1°C
Cell: Meta flow cell
Quantity of fed sample: 200-2000
2000μ l
Colorimetric cup: 12.5mm×12.5mm square test tube
Cross contamination: 1.5% (300μl)
≤1.5% (300
Storage: 60 test items, 2000 test results
Interface: RS-232
232 bidirectional communication interface
Display: Large screen, highly bright and clear
monochromatic LCD Display resolution: 240*64
pixels
Printer: Built--in or external serial printer
Computer MCS--51 series 8 digit single-chip computer
Operating environment: 15°C-- 32°C; Maximum humidity: 85% R.H. (below
30°C)
Storing environment: -20°C
20°C-50°C; Maximum humidity: 85% R.H. (below
30°C)
Weight: 7kg
Dimensions: 360mm(L)×318mm(W)×160mm(H)
Fuse: 250V, 3.15A
Power supply: 110VAC or 230VAC±10%,50/60±1Hz
22
3 FUNCTIONS
3.1 Function block diagram
3.1-1 Function block diagram
3.2 Functional description of the power supply

Powered by the switching power supply module and adopting high high-frequency
PWM conversion technology, the power supply is small in size, light in weight,
high in efficiency dependability. Its load and power adjusting ranges are wide.
This power supply outputs
outputs two DC electrical sources, each electrical source is
described as follows:
CH1: +12V/4A It is used for the motors of filter and peristaltic pump,
heating/cooling of Peltier and the motor of the fan as
well.
CH2: +5V/8A It is used for the logical control
ontrol of the rear board and
the front
ont board, Tungsten Halogen Lamp, built built-in
printer and heating/cooling of Peltier

23
3.3 Rear board functions
3.3.1 FUNCTIONAL DESCRIPTION ON OF THE REAR BOARD

As the system platform, it provides hardware environment for the operation of
system software.
It provides an interface connected to the font system, control of the font system
and processing of data collected by the font system.
It provides I/O interfacess of the system, I/O interfaces supported by it comprises
three RS232 interfaces which are respectively used for built-in
built serial printer,
exterior RS232 interface 1 and exterior RS232 interface 2, one parallel printer
interface (Not used), one keyboard panel
pan interface, one interface for LCD with
resolution of 240*64 pixels and the front ISA bus interface.
3.3.2 FUNCTION BLOCK DIAGRAM

AM OF THE BACK BOARD
3.3-1 Function block diagram of the rear board

24
3.3.3 PRINCIPLE DESCRIPTION OF THE REAR BOARD

As the above figure indicates, the rear board mainly consists of the following
parts:
1. MCU, SRAM and the embedded FLASH memory in MCU constitute the basic
platform for the operation of the system; the system software is embedd
embedded
in the Flash Memory which is in MCU. As the hardware structure of MCS MCS-51
one chip computer is based on Harvard principle, namely the addressing of
one-chip
program space and the addressing of data space are independent of each
other. Address space of 64K Flash Memory
Memory is allocated in the 64K program
space of the system, 60K SRAM address space and 4K system I/O address
space are allocated in the 64K data space of the system. The CPU external
frequency is 22.1184MHz. When the system is started, program runs in the
Flash
lash Memory directly.
2. Serial communication port
There are three serial communication ports on the rear board, namely: RS232
port, which is composed of serial port 0 of MCU and is connected to PC, for
upgrading of external programs; additionally provided two serial ports and
one parallel port for the system through TL16C552 chip extension. Therein,
one of the two serial ports is used for the built-in
built in printer, and the other is
used for transmitting the test result.
3. PLC
PLC provides the logic control over all
all parts of the system. Through extension,
the PLC provides a port for controlling eight LED indicators, and provides
control over transformation of interrupt signal and local bus which is
connected to the font, and allocates decoded address of the system.
4. Scanning the keyboard
Keyboard scanning logic of 5×5 array is formed by the lower 5 digits of PA
and the lower 5 digits of PB of 8255 chip; 8255 chip sends out keyboard
scanning signal from PA port periodically and detects any press onto the key
through PB port.
5. Power transformation circuit
System power supply provides +5V power for the rear board, the rear board
needs +5V power and +3.3V power. Therefore, +5V power must be
transformed to +3.3V power to meet the need of the rear board.

25
3.4 Front board functions
3.4.1 DESCRIPTION OF FRONT

ONT BOARD FUNCTIONS
The front board, under the control of the rear board, provides the following
functions:
 Choosing spectral filter
 Peristaltic pump rotates and draws in a certain amount of liquid
 Control of tungsten halogen lamp
amp (on / off)
 Transformation, amplification and sampling of photoelectric signal.
 Detection and controlling of temperature
3.4.2 PRINCIPLE BLOCK DIAGRAM RAM OF FRONT BOARD

Principle block diagram of front board is shown as followings:
Measurement
position
Logic Spectral Spectral filter

filter circuit
control stepping
Driving
motor
L Motor of the Stepping

Logic motor of the
o peristaltic pump
control peristaltic
g Driving circuit
i pump
c
Temperature
control of Peltier Peltier
c
o
n Temperature detection
t
r
Logic control for
o Tungsten
tungsten
l halogen lamp
halogen lamp
A/D Circuit for photo

conversion electric receiving
and conversion
3.4-1 Function block diagram of the front board

26
3.4.3 CONTROLLING OF CHOOSING SPECTRAL FILTER

There are five different spectral filters available with the wavelength of 340nm,
405nm, 500nm, 546nm and 620nm. Spectral filter varies with different testing
method. Install
Install all the spectral filters evenly on the round plate with 8 holes,
contained angle of any two adjoining holes is 360/8 =45°. One surplus hole is
spared for further installation of spectral filter for special wavelength. The
stepping motor drives the plate
plate rotating. Spectral filter the system chooses
varies with rotating angle of the stepping motor.. The motor is equipped with a
reducing gear box to increase its rotational torque.
3.4.4 CONTROL OVER LIQUID-INTAKE OF THE PERISTALTICALTIC PUMP

The analyzer can automatically
aut aspirate certain amount of reagent according to
the preset amount in the test. The amount of reagent the instrument intake
varies with the rotation angle of the stepping motor. Eight different rotational
speeds are available according to different
nt concentration of sample to be tested
and different intake speed provided to users.
3.4.5 DETECTION AND CONTROLLING

LLING OF TEMPERATURE
Temperature control consists of temperature detection and control over
heating/cooling.
3.4.6 SAMPLING AND TRANSFORMATION OF LIGHT ENERGY ERGY

The
he detection of light energy is performed by a Silicon photocell and builtbuilt-in
operational amplifier. The silicon photocell transforms photocurrent into faint
voltage signal and the built-in
built in operational amplifier amplifies the faint voltage
signal to meet the measurement requirement in voltage. The so transformed
digital signal is processed in the CPU, The scope of the voltage input A/D is
0-10V.
10V.
3.4.7 CONTROL OF THE TUNGSTEN HALOGEN LAMP

To prolong service life of the 6V/10W tungsten halogen lamp
lamp, the instrument is
turning off the light source automatically if the instrument is not in service for
some time.

27
3.5 Functional description of the pipeline
3.5.1 FUNCTIONAL SPECIFICATIONS

TIONS
When the aspiration key is pressed during the measurement process, the system
makes the motor of the peristaltic pump rotate and the wheel of the peristaltic
pump presses against the pipeline tightly to make the liquid flow to the outlet
and thus the liquid is intaken into the cell.
c Once aspirating the correct amount
preset in the test item, the system will stop the motor of the peristaltic pump.
The liquid will stay in the cell for measurement. After the measurement, the
system urges the motor of the peristaltic pump rotate and drains the liquid in
the cell to reduce cross contamination and waits for the next measurement.
3.5.2 STRUCTURE OF THE PIPELINE

ELINE
3.5-1 Structure figure of the pipeline
3.6 Functional description of the optical path

pa
3.6.1 FUNCTIONAL SPECIFICATIONSTIONS

Optical structure is given as follows. It is the back-dividing-light
back structure of the
interference spectral filter. Radiation the tungsten halogen lamp giving off goes
through the convex lens and is turned into parallel rays. TheT protective glass is
used to protect the convex lens. The parallel light casts into the cell which is
loaded with liquid to be tested, part of the light energy is absorbed by the liquid
and the light out becomes monochromatic light after goes through the
monochromatic spectral filter. Then the monochromatic light casts onto the
photoelectric receiver and is converted into electronic signal thereafter and
28
input into the front board for processing. Color of the spectral filter and that of
the solution to be tested should be complementary colors.

29
3.6.2 STRUCTURE OF OPTICAL PATH
3.6-1 Diagram of optical path
1) 6V/10W tungsten halogen lamp

2) Protective glass
3) Convex lens
4) Flow cell
5) Filter
6) Photoelectric sensor
30

31
4 REPLACEMENT OF MODULES
4.1 Disassembling of the analyzer

1. Drain residual solution in the pipeline thoroughly and fix the flow cell..
2. Power off the analyzer and disconnect the power cable.
3. Place a piece of soft silk on a clean and even worktable and then place the
analyzer on the silk upside down so as to prevent the surface of the plastic
upper lid from being damaged .
4. Loose the two tapping screws which are used to fasten the plastic upper lid
onto the metal base with a screwdriver.
4.1-1ST3 tapping
Position screwof screws on the upper and lower
diagram ST3lids
tapping screw
And then loose the two screws at the back of the instrument. See the diagram
below.
32
M4 screw M4 screw
4.1-2 Position diagram of the rear screws
5. Place the whole instrument on the worktable carefully and open the lid for
the light source and take out the aspiration tube from the hole in the plastic
upper lid.
6. Hold the front side of the plastic upper lid with your hands and raise it
carefully, notice that there are several cables connecting the upper lid and
the lower lid, exert decent force so as not to damage
damage the cable plugs /sockets.
Unplug the connecting cable when detach the upper lid and the lower lid.
The diagram below shows the view of the upper lid and the lower lid after
they are detached.

33
Peristaltic pump Power supply
Rear board
Optical path
Front board
20Pin flat
5Pin
2Pin
Printer
LCD display
Filmed keyboard
Light source cover
cable
cable
Fig 3-3
3 View of the upper lid and the lower lid after they are detached:
34
4.2 Replacement of lamp

Structure of the light source is shown as the diagram:
1
2
3
4
3 Is the fastening screw. It is used to fasten the light

light source onto the lamp
holder.
2 And 4.are
.are adjusting screws. Finely adjust position of the light source so as to
adjust the light intensity
1 Is the power cable of the light source.. Power for the light source can be
available once the power cable is connected to the main board.
1. Shut down the instrument and open the cover of the apron of the light
source, remove the power cable of the light source and loose the screw 3 to
remove the light source.
Place the new light source in the holder and fasten the screw 3 and connect the
powe cable to power supply.
power

35
2. Mount the screw 2 and screw 4. Do not screw them excessively.

3. Start the machine, enter main menu, choose " whether 3 system set up "
select, " 4 only better to test " after entering " first, set up wavelength as
340nm, suck according
ording to " RINSE " distilled water wash pipeline about half
minute, press, suck distilled water test 340 AD value and then first.
4. Slide the light source back and forth to maximize the tested AD value (value
in the round brackets).
5. Adjust screw 2 and screw 4. Note that direction of movement for 2 and 4 are
opposite. Unscrew screw 4 and tighten screw 2 simultaneously to make the
AD value stay at 3000 or around (Any value between 2500 and 3800 is
acceptable) and then fasten screw 3.
6. Fasten screw 3 and return the apron of the light source.
4.3 Replacement of switch

1. Shut down the instrument and unscrew the screw on the base and remove
the upper lid of the instrument.
2. Unplug the (1), (2), (3) connectors (Fig. 4.3-1).
36
3. Clamp the spring pieces (4) on each side of the switch base. Push the switch
base outwards and then remove it (Fig. 4.3-1).
4. Pull out the power cable (5) and (6) from the connector on the switch and
clamp the spring pieces on each side of the switch and pu push out the switch
(Fig. 4.3-1).
5. Pick a good switch and turn the “I”
“ ” mark toward the socket direction and plug
it into the switch base.
6. Connect the power cable (5) and (6) to the connector of the switch (Fig.
4.3
4.3-1).
7. Press the switch base into the instrument
instrume base (Fig 4.3 3-2) and make sure the
plug of the power cable toward the fan direction (Fig 4.3
4.3-2).
8. Connect the (1), (2), (3) power cables (Fig. 4.3-1).
9. Return the upper lid and fasten the screw on it and then start the instrument
(Avoid the cables on the upper lid being pressed by the screw head lest the
cab be damaged).
cables
3 5 1 2
6 4

37
Cable socket Fan
4.4 Replacement of spectral filter

1. Open the upper lid of analyzer HumaLyzer Primus and handle the connecting
cables between the upper lid and the main board carefully.
2. Loosen the screws on the Cassette of the spectral filter.
Cassette of filter
38
3. Pull out the mask and loosen the 3 screws on the spectral filter wheel at the
same time as the figure indicates.
Mask piece
Screws
4. Unscrew the fastening screws and unload stepping motor.
5. Pull out the stepping motor first and then take out the spectral filter plate as
the figure indicates.
Screw on the spectral

filter wheel which
has been loosened

39
6. The spectral filter plate which has been taken out
670nm
546nm
340nm
Fastening
copper ring
Notch
7. Each spectral filter for specific wavelength is shown as the figure.

Wavelength the notch corresponding is 340nm. All wavelengths from 340nm
to 670nm are sequentially arranged clockwise.
8. Take out the fastening copper ring carefully, and then take
ta out the old
spectral filter.
Filter and ring
9. Mount a new spectral filter for corresponding wavelength and return the
fastening copper ring thus the replacement of the spectral filter is
completed.
10. To install the spectral filter into the cassette, follow the above mentioned
disassembling procedures in a contrary order.
40

41
4.5 Replacement of signal receiving board

Signal receiving board is used to convert the ever changing optical signal into
electronic signal for further calculation. It is the most important component in
the optical system. To replace it, see the procedures as follows.
1. Unscrew the screws and remove the Cassette then you can see the signal
receiving board.
Signal receiving board
2. Unscrew the 3 screws with red spacers and pull out the receiving board then
you can have a full look at the board.
Signal
receiving
module
Power cable
3. Replace a new signal receiving module and insert the power cables
sequentially then screw the screws and mount the spacers.
4. Insert the other end of the power cable into the 6pin plug P on the front
board firmly, then the signal receiving module can operate normally.
42
Front board
Note: For the new signal receiving board, there are two corresponding plugs,
4pin and 2pin respectively, on the front board.
4.6 Replacement of pipelines

Note: Perform the following procedures with care and don’t drop any water
onto the circuit board.
Replacement of pump tube
The overall view of peristaltic pump:

Snap
Adjusting screw Stop bar
Pump tube
Pump body
Motor
Copper
column
The copper column is used to fix the pump body onto HumaLyzer Primus base.

43
1. Loose the adjusting screw, open the stop bar.
Stop bar
2. Open the snap, the pump tube can be seen.
Snap
Pump tube
3. Remove the pump tube, shear off the bandage, you can separate the pump
tube from the white cuff.
Bandage
White cuff
4. Replace the pump tube with a new one, bandage, and do the operation
procedures above reversely, and adjust tightness through adjusting screw
finally.
44
5 REGULAR MAINTENANCE
5.1 Summary
HumaLyzer Primus is a precision clinical analyzer. For ensuring its good
conditions, daily maintenance should be done. Maintenance is very simple, but it
should be carried out carefully.
5.2 Cleaning the analyzer
5.2.1 CLEANING THE SURFACE OF THE ANALYZER

● Keep the operating environment of the analyzer clean.
● Neutral detergent and wet cloth can be used for cleaning the surface of
analyzer.
● Please use a soft cloth to clean the LCD.
Warnings: Caution: Do not let the analyzer be exposed to any solvent, oil, and
other corrosive substances.
5.2.2 CLEANING THE CELL

The cell should be kept clean for ensuring the accuracy of the measured result.
5.2.3 CLEANING THE OUTSIDE OF THE CELL.

a. The cell should be installed according to the requirements (refer to 1.1.5).
b. If the outside of the cell is dirty, a piece of soft cloth with absolute alcohol
can be used for cleaning.
5.2.4 CLEANING THE INSIDE OF THE CELL

a. Put a container full of distilled water under the aspiration tube tube, press RINSE
key to start continuous rinsing function.
functi Then pres RINSE key again to stop
rinsing. Normally it takes half a minute for continuous rinsing.
b. Detergent for glass container, dilute hydrochloric acid (0.1N), and Tween20
diluent (2-3
(2 drops/L) can be used for cleaning the flow cell cell. Press RINSE key to
suck the detergent, press RINSE key again to stop the running of the
peristaltic pump to let the detergent remain in the cell for 5min., and rinse
the cell with distilled water for 1 min. finally. If it isn't clean enough, rinse the
cell with detergent again.

45
The cell should be cleaned under the following conditions:

 Water blank difference is too large at the starting moment
 Change the testing item
 Before shut-down
Warnings: Do not leave the reaction liquid or other

oth pollutants in the cell for a
long time.
46
6 PROBLEM-SOLVING
PROBLEM GUIDE LINE
6.1 Fix pump tube

Before running the instrument, please tight the screw to fix the pump tube.
Please tight the

he screws to fix the
pump tube. Ensure
nsure approximate
distance of the gap
gap.

47
6.2 Change the chip
Please ensure the flat end on the right position. Please use the tool or forceps to
take the chip out then install the new forceps carefully.
48
6.3 Optical setting instructions

In system setting menu, click the number’4’ key , Instrument will display the
menu as Figure 2-7
2 (a),
Figure 2-7
2 AD real-time value
Wavelength. 2：340
Save?
AD
AD：3266
(a) AD value display interface (b) Filters position

position（face to rear of the
filter wheel）
wheel
(1) Save every filters’ zero-blanking value
Press RINSE key to aspirate distilled water（make
water make sure pipeline full
full），press Left
and Right button （）change the wavelength。when when the AD value keep
stable press ENTER button to save the current filters AD value ，if the value
stable，press
has been saved,
saved, the word “Save?” will disappear .AD value is used for program
testing calculation please save properly.
(2) User
User-defined filters
1. User can change or add filters to the instrument according to requirement
requirement，
but filters must be installed as Figure 2-7(b)
2 7(b) describ
described .（the wavelength
displayed on Figure 2-7
2 7 (a) is correspond to the filter position on 2
2-7 (b) ）
Face to rear of filter wheel(installation face) ,take the trough as a reference

point, just like 2-7(b)
2 7(b) described, The filters in position 2 2、3、4、5、7 were
installed
stalled in factory as standard collocation, no filters in position 1
1、6、8 。
Note : Don’t install filter to the position 1,because this position rest on light path
when instrument not testing.
2. After filter has been installed properly, turn on instrument anand enter the AD
value display interface, as 2-7(a).
2 Press RINSE key to aspirate distilled water
(make sure pipeline
pipel fully flooded), then
hen press Left or Right button
button（） to

49
find the position installed new filter, and then press .(dot)168, the
wavelength value “None” will be lighted, at this moment, you can input the
new filter’s wavelength value, when the AD value keep stable，press
stable ENTER
key to save the current filter’s wavelength value and corresponding AD value.
6.4 Change
e the input voltage between 110V and 220V
220
1. Please turn off the instrument. Take off main cover and disconnect inside
cables carefully. You should see the power supply like on the figure 1.
Figure 1
2. You could take tweezer to change the input voltage by adjusting the red
button as Figure 1. Or, remove the power supply‘s cover, it should be more
convenient to adjust the button.
When
hen the button been set on “115V”
“115V as below figure, the input voltage should
between AC 110V±10%
50
When
hen the button been set on “230V”
“230V” as below figure, the input voltage should
between: AC 220V±10%
220

HUMAN
Gesellschaft für Biochemica und Diagnostica mbH
| Max-Planck-Ring 21 · 65205 Wiesbaden · Germany
| Tel.: +49 61 22/99 88-0 · Fax: +49 61 22/99 88-100
| e-Mail: human@human.de · www.human.de

Humalyzer Primus Service Manual

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HumaLyzer Primus

SERVICE UND SUPPORT

HumaLyzer Primus | Service manual

HumaLyzer Primus | Service manual

1.1 User Warranty

1.2 Intended Use of the Instrument

1.3 General Safety Warnings

1.4 Disposal Management Concept

HumaLyzer Primus | Service manual

1.5 Biohazard Warning

1.6 Instrument Disinfection

Warning: Warning indications must be obeyed in order to ensure the

Warning and Safety Indications

HumaLyzer Primus | Service manual

Note: To change the internal power supply of the instrument to be

This change shall only be performed by a HUMAN GmbH trained service

HumaLyzer Primus 1 [REF]:18200

Flow Cell 1 [REF]:18200/15

User Manual 1 [REF]:18200/100

Power Cord 1 [REF]:18200/75

Spare Fuse 2 [REF]:18200/41

Aspiration Tube 1 [REF]:18200/18

Pump Tube 1 [REF]:18200/19

Dust Cover 1 [REF]:18200/80

Waste Bottle 1 [REF]:18200/81

2.2 Product Features

2.3 Product Structure and Composition

HumaLyzer Primus | Service manual

2.4.1 SELECTING A PROPER LOCATION FOR FO THE INSTRUMENT

Note: The temperature of the instrument’s operating environment

In order to ensure proper functioning of the instrument, it may not be placed in

2.4.2 POWER SUPPLY REQUIREMENT

2.4.3 CONNECTING THE INSTRUMENTUMENT TO POWER SUPPLSUPPLY

AC power must be well earthed (near-ground voltage <5V).

The AC power supply must be stable. High-power

When removing the power cable, pull on the plug instead

HumaLyzer Primus | Service manual

2.4.4 INSTALLING THE FLOW CELL

2.4.4-1: Opening the lamp cover

1. Remove the adhesive tape used to secure the flow cell.

Ensure that the aspiration tube is in the socket. Otherwise,

2.5 Main Structure

2.5.1 FRONT VIEW

2.5.1--1: Front view

1. Printer cover 5. Keypad

HumaLyzer Primus | Service manual

Direction keys: Move the cursor in four directions on the

Rinse key: Clean the pipeline.

Exit key: Exit the menu and cancel the operation.

Enter key: Confirm the input and save.

2.5.3 BACK VIEW

2.5.3--1: Back view

1) Parallel port for printer (not used) 6) Fuse

2) RS-232 serial port 7) AC input

3) RS-232 serial port 8) Fan

4) Drain port 9) Backplate label

5) Power switch 10) Peristaltic pump

2.5.4 INTERNAL PRINTER

HumaLyzer Primus | Service manual

2.5.5 FLOW CELL AND CUVETTE

2.5.5-1: Opening the lamp cover

2. Internal components of the colorimetric system

2.5.5--2: Internal components of the colorimetric system