Appendix 1

Table 3. Hematological reference ranges for healthy Malaysian population.

Variable

Male

Female

6-12 yrs*

2-6 yrs*

2-6 mth*

1 mth*

neonate*

3.8 9.7

3.4 10.1

5 - 13

5 - 15

6 - 18

5 - 19

7 - 23

12

4.2 6.1

3.52 5.16

4.0 - 5.2

4 - 5.3

3 - 4.6

3 - 5.4

4.0 - 6.6

HGB(g/dl)

12.0 16.5

9.81 13.85

12 - 16

11 - 14

10 - 14

11 - 17

15 - 23

HCT (%)

37.5 49.8

31.8 42.4

35 - 45

34 - 40

28 - 42

31 - 55

45 - 67

MCV (fl)

78.9 95.7

77.5 94.5

78 - 94

75 - 87

83 - 108

85 - 123

95 - 121

MCH (pg)

25.4 31.1

24.8 31.2

24 - 33

24 - 30

25 - 35

28 - 40

31 - 37

30.6 34.9

29.4 34.4

31 - 37

31 - 37

30 - 36

29 - 37

29 - 37

167 376

158 410

1.58 5.94

1.55 6.07

28

1.5 8

1.5 9

39

35

1.14 3.22

1.05 3.29

15

69

4 10

3 16

28

0.15 0.67

0.1 0.74

0.1 1

0.1 1

0.1 1

0.3 1

0.5 1

0.08 0.28

0.03 0.28

0.1 1

0.2 1

0.2 1

0.2 1

0.1 0.5

0.01 0.05

0.01 0.05

Reticulocytes (x10 /l)

0.46 1.34

0.48 1.48

0.2 - 2

0.2 2

0.4 1

0.3 1

1 4.5

Reticulocytes (%)

0.92 1.05

0.96 1.03

1 - 15

1 - 20

WBC (x10 /l)

RBC(x10 /l)

MCHC (g/dl)
9

Platelets (x10 /l)

9

Neutrophils (x10 /)
9

Lymphocytes (x10 /l)

9

Monocytes (x10 /l)

9

Eosinophils (x10 /l)

9

Basophils (x10 /l)

9

ESR (mm/h)

1 10 (children)

Source: T.M. Roshanet al., (2008) Hematology Reference Ranges in Malaysian Population. Int. Jnl. Lab. Hem.
th
*Source: J.V. Dacie, S. M. Lewis, (1995) Practical Haematology (8 Edition), page 17.

Appendix 1
Table 4. Coagulation reference ranges for healthy Malaysian population.
Variable
PT (sec)

Normal Range
12.6 15.7

INR

0.86 1.14

APTT (sec)

30.0 45.8

APTT (sec)

< 5 sec

Interpretation based on correction value calculated from

standard formulae (50:50 mix/control)
Clauss Method

Fibrinogen Level (g/l)

2.32 4.44

D-dimer (g/ml)

< 500

50.0 190

57.0 156.0

Factor VIII Assay (%)

Factor IX Assay (%)

Note

Source: Coagulation normal pool studies on STA Compact (Mei, 2008)

Variable
Thrombin Time (sec)

Normal Range
14.37-18.23

Reptilase Time (sec)

< 20

Factor II Assay (%)

48.0 155.0

Factor V Assay (%)

67.0 -134.0

Factor VII Assay (%)

70.0 160.0

Factor X Assay (%)

67.0 123.0

Factor XI Assay (%)

63.0 145.0

Factor XII Assay (%)

40.0 130.0

Factor XIII Assay (%)

40.0 130.0

Inhibitor Screening

No Inhibitor

Inhibitor Assay (Bethesda Assay)(BU/mL)

Note

< 0.6

Protein C Activity (%)

69.0 132.0

Protein S Activity

77.0 136.0

Free Protein S Antigen Activity (%)

67.0 155.0

Antithrombin (ATIII) (%)

80.0 160.0

>2.05

2.09 3.21

APCR-V (ratio) cut of value

APCR-APTT (ratio)
Anti Xa Activity (/ml)

0.5 1.0

Therapeutic range

Source: All reference ranges and value obtained from Coagulation normal pool studies, December 2008.