Litt's Drug Eruption & Reaction Manual 24E

24th
EDITION
Jerome Z. Litt
Neil H. Shear
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CONTENTS
Introduction v
Drug profiles: generic names A–Z 1
Descriptions of important reactions 305
Drugs that cause important reactions 311
Main classes of drugs 345
Classes of drugs that can cause important interactions 351
Class reactions 353
ACE inhibitors 353
Antiarrhythmics 355
Antibiotics, macrolide 357
Anticonvulsants 358
Antidepressants, tricyclic 361
Antihistamines (H1) 362
Antimalarials 363
Antipsychotics 365
Benzodiazepines 367
Beta blockers 368
Biologics 369
Bisphosphonates 374
Calcium channel blockers 375
Cephalosporins 377
Disease-modifying antirheumatic drugs (DMARDS) 378
DPP-4 inhibitors 383
Epidermal growth factor receptor (EGFR) inhibitors 384
Fluoroquinolones 387
Non-steroidal anti-inflammatory drugs (NSAIDS) 389
Proton pump inhibitors (PPI) 392
Statins 394
TNF inhibitors 395
Tyrosine-kinase inhibitors 398
Concordance of synonyms and trade names with
generic names 403
iii
To Vel – my Muse
JZL
Editors’ introductory notes
Any drug has the potential to cause an adverse reaction. An adverse drug reaction (ADR) is an unwanted, unpleasant, noxious,
or harmful consequence associated with the use of a medication that has been administered in a standard dose by the proper
route, for the purpose of prophylaxis, diagnosis, or treatment. Death is the ultimate adverse drug event.
ADRs are a major problem in drug therapy. They are the most common of all iatrogenic illnesses that complicate up to 15%
of therapeutic drug courses, and are a leading cause of morbidity and mortality in healthcare. ADRs should therefore be con-
sidered in the differential diagnosis of a wide variety of medical disorders. Many more people – particularly the elderly – are
taking more and more prescription and over-the-counter medications. In addition, new drugs are appearing in the medical
marketplace on an almost daily basis. It is unsurprising, then, that more and more drug reactions and cutaneous eruptions are
emerging.
Prevention, diagnosis and treatment of adverse drug events are becoming increasingly complex, and it is to be expected that
physicians in all specialties are often perplexed by the nature of ADRs. To this end, I now offer a new and improved edition
that has evolved from the treasured Drug Eruption Reference Manual of previous editions. I hope that you will find this new
edition informative and valuable.
Enjoy!
Jerome Z. Litt, M.D.
“Is it safe?”
I am frequently asked that big question from a patient: "Is it safe?" This text is meant to help all prescribers, dispensers and
patients understand what the risk of harm might be; whether it is from a drug reaction or interaction, Litt's is the go-to infor-
mation source. How does this information help answer the unanswerable? Simply put, safety is a process, not a question. With
the right information at hand a safe environment can thrive; the most up-to-date relevant data help peel away background
noise from a seemingly infinite number of sources. This new edition adds additional support to a risk management environ-
ment, and we will continue to provide the most up-to-date and relevant information. I look forward to feedback and sugges-
tions. I thank Jerry Litt for this great opportunity and the awesome work of the team at T&F to keep on top of all new
medications that are making the landscape even more complex.
Neil H. Shear, M.D., F.R.C.P.C., F.A.C.P.
Litt’s Drug Eruption & Reaction Manual – at a glance

This 24th edition has been revised and updated throughout to present a quick clinical reference guide to adverse drug
reactions (ADRs), side effects, drug interactions and other safety information for prescription and over-the-counter medica-
tions. There is also material on reactions caused by classes of drugs, enabling you to see at a glance whether a reaction is
common to all the drugs in that particular class, or to a majority of them, or only to a significant few.
The aims of this edition remain:
1. To help medical practitioners make informed and safe decisions when diagnosing and prescribing, and also when
generally seeking information.
2. To help healthcare professionals remain pharmacovigilant.
3. To provide all physicians, lecturers, educators and pharmacists with an easy-to-use and reliable quick reference tool.
The full and comprehensive picture for all drugs – from which our information derives – can be found at our website database
(www.drugeruptiondata.com), which is updated continually. Space in the manual is, unfortunately, constrained, so full profiles
for various generic drugs have been eliminated from this print manual because either they have been withdrawn from the
marketplace or they are rarely, if ever, prescribed today; new to this edition are links to their basic profiles in the website
database. Important new drugs added to this edition of the manual are noted with an asterisk.
v
A note on ADRs
The incidence and severity of ADRs are influenced by a number of factors:
1. Patient-related factors:
• Age – geriatric, pediatric, adolescent . . . older patients are taking more medications—hence more of a possibility of
developing reactions; pediatric patients have more delicate skins; hormonal changes occur in adolescents . . . All these
factors play roles in the development of possible adverse reactions.
• Gender – male or female – and if the latter, then pregnant/breast-feeding/menopausal . . .
• Disease – not only the disease being treated, but also other pre-existing health conditions and comorbid diseases. For
example, atopic patients are at increased risk for serious allergic reactions. Also, there would be an increased risk for
hypersensitivity drug reactions if the patient has asthma or lupus erythematosus.
• Genetics – a patient could have abnormal drug metabolism by cytochrome P450 due to inheriting abnormal alleles.
• Geography – patients living in sunny climes could develop photoxicities from photosensitizing drugs more readily than
those who inhabit cooler, less sunny climates.
2. Drug-related factors:
• Type/class of drug – for example, there is a heightened risk of hypersensitivity with the use of beta-blockers (see further the
tables on class reactions).
• Duration of therapy – the longer a patient maintains the therapy, the greater the possibility that he/she could develop a
reaction.
• Dosage – the greater the dosage, the more likely an adverse side effect.
• Bioavailability – the extent to and rate at which the drug enters systemic circulation, thereby accessing the site of action.
• Interactions with other drugs – for example, synergistic QT prolongation can occur when two QT prolonging agents, such
as erythromycin + ritonavir, are used together.
• Route of administration – intramuscular, intravenous, subcutaneous, and topical administrations are more likely to cause
hypersensitivity reactions; oral medications are less likely to result in drug hypersensitivity.
The terms “drug allergy,” “drug hypersensitivity,” and “drug reaction” are often used interchangeably. Drug allergy specific-
ally refers to a reaction mediated by IgE; drug hypersensitivity is an immune-mediated response to a drug agent in a sensitized
patient; and drug reactions comprise all adverse events related to drug administration, regardless of etiology.
Vigilance at point of care:

While the possibilities for adverse drug reactions seem endless, we must be on the lookout for any new medication(s) the
patient might be taking. A thorough, detailed history of all medications must be made in order to elicit any remote possibility
that the drug in question might be the culprit for the side effect. People do not often realize that the common over-the-
counter analgesics – aspirin, Tylenol, Advil, Motrin, Naprosyn, and others – are actually medications. Herbals and supple-
ments such as St. John’s wort, ginkgo biloba, and echinacea can be responsible for various hypersensitivity reactions. For
example, St. John’s wort, in particular, interacts adversely with SSRIs and tricyclic antidepressants.
Contents of the book, and how to use them

1. The A–Z
The major portion of the manual lists in alphabetical order the 900+ generic drugs, biologics, and supplements, and
the adverse reactions that can arise from their use. An asterisk against the entry title indicates this drug is new to this
edition. If you do not find a drug in the main A–Z listing under the name you know it by, you can turn to the concord-
ance of synonyms and trade names to find the generic name it will be listed under. Occasionally a drug has been
omitted from the listing but a cross-reference will link to the profile found in our website database
(www.drugeruptiondata.com).
vi
Trade (Brand) name(s) are then listed alphabetically. When there are many trade names, the ten (or so) most
commonly recognized ones are listed.
Following the trade names is – in parentheses – the latest name of the pharmaceutical company that markets the drug.
Many of the names of the companies have changed from earlier editions of this manual because of acquisitions,
mergers, and other factors in the pharmaceutical industry.
Next appear the Indication(s), the Class in which the drug belongs, and the Half-life of each drug, where known.
Drug interactions: many severe, hazardous drug–drug interactions are recorded. Only clinically significant drug inter-
actions that have been reported to trigger potential harm and that could be life threatening have been included here in
the profile. These interactions are predictable and well documented in controlled studies; they should be avoided.
Pregnancy category: for new drugs approved on or after 30 June, 2015 this field gives (where available) a brief sum-
mary of the full statement reflecting the risk for pregnant women as given in the prescribing guidelines; health care
providers are advised to check the individual label where necessary.
An explanation of the categories for older drugs (A, B, C, D and X) can be found on our website
www.drugeruptiondata.com.
Adverse Drug Reactions: under each drug profile is a list of related ADRs. These adverse events have been classified
under the following categories: Skin, Hair, Nails, Mucosal, Cardiovascular, Central Nervous System,
Neuromuscular/Skeletal, Gastrointestinal/Hepatic, Respiratory, Endocrine/Metabolic, Genitourinary,
Renal, Hematologic, Otic, Ocular, Local, Other.
Within each category, the reactions are listed alphabetically. Thus, the order of listing does not reflect severity or
frequency in any way.
The terminology used to list reaction patterns has been simplified as far as possible by eliminating, for the most part,
tags such as “like” (as in “-Psoriasis-like”), “-reactivation,” “-syndrome,” “-dissemination,” “-iform,” etc.
The number of reports is given for each reaction in square brackets. The incidence of the most important reactions is
given in parentheses where indicated (usually from the full prescribing information for the relevant drug). For
example, the profile for Amoxicillin begins:
Skin
AGEP [28]
Anaphylactoid reactions/Anaphylaxis [15]
Angioedema (<10%) [5]
This means that we have 28 journal articles referring to occurrence of AGEP (acute generalized exanthematous
pustulosis ); 15 articles mentioning the occurrence of anaphylaxis; and 5 articles discussing angioedema, as reactions to
Amoxicillin within the Skin category. All these articles appear on the website www.drugeruptiondata.com together
with links to the article abstracts on PubMed®. Additionally, the incidence of angioedema as a reaction has been
reported as up to 10%.
On some occasions, there are very few adverse reactions to a specific drug. These drugs are still included in the
manual as there is a positive significance in negative findings.
2. Important eruptions / reactions

i) This section of the manual includes a listing of descriptions of important eruption and reaction patterns. Over 40
eruptions/reactions are described here in alphabetical order, from Acanthosis nigricans to Xerostomia.
ii) Following this section are lists of all drugs that have been found to cause these important eruptions/reactions. This
section is a quick look-up tool for drugs that cause important reaction patterns.
(Descriptions of several other reactions, and lists of drugs associated with these reactions, can be found on our
website – www.drugeruptiondata.com.)
iii) We then have a list of the main classes of drugs, from 5-HT1 agonists to Xanthine alkaloids, as a quick reference guide.
iv) There follow lists of the classes of drugs most likely to cause important interactions with other drugs, with the drugs in
those classes.
v) We then have an enlarged section of tables of class reactions, enabling you to see at a glance whether a reaction is
common to all the drugs in that particular class, or to a majority of them, or only to a significant few.
vii
3. The Concordance
The final part of the manual is a concordance to match synonyms (noted in italic) and trade names with the generic
drug name. If you know only the synonym or trade name, you can use this list to find the corresponding generic name
to look up in the main A–Z listing section of the book.
viii
Hypertriglyceridemia (2–6%)
ABACAVIR Renal
ABATACEPT
Trade names: Epzicom (ViiV), Triumeq (ViiV), Fanconi syndrome [2] Trade name: Orencia (Bristol-Myers Squibb)
Trizivir (ViiV), Ziagen (ViiV) Hematologic Indications: Rheumatoid arthritis, juvenile
Indications: HIV infections in combination with Agranulocytosis [3] idiopathic arthritis in pediatric patients 6 years of
other antiretrovirals Neutropenia (2–5%) age and older
Class: Nucleoside analog reverse transcriptase Other Class: Disease-modifying antirheumatic drug
inhibitor Adverse effects [4] (DMARD), T-cell co-stimulation modulator
Half-life: 1.5 hours Infection (5%) Half-life: 1223 days
Clinically important, potentially hazardous Clinically important, potentially hazardous
interactions with: alcohol, arbutamine, interactions with: adalimumab, anakinra,
argatroban, arsenic, darunavir, ganciclovir, certolizumab, denosumab, echinacea, etanercept,
lopinavir, methadone, phenobarbital, phenytoin, ABALOPARATIDE * golimumab, infliximab, lenalidomide, live vaccines,
protease inhibitors, ribavirin, rifampin, tipranavir, natalizumab, pimecrolimus, sipuleucel-T,
valganciclovir Trade name: Tymlos (Radius Health) tacrolimus, TNF antagonists, trastuzumab
Pregnancy category: C Indications: Osteoporosis in postmenopausal Pregnancy category: C
Important contra-indications noted in the women Important contra-indications noted in the
prescribing guidelines for: nursing mothers Class: Parathyroid hormone analog prescribing guidelines for: nursing mothers;
Note: Epzicom is abacavir and lamivudine; Half-life: <2 hours pediatric patients
Triumeq is abacavir, dolutegravir and lamivudine; Clinically important, potentially hazardous
Trizivir is abacavir, lamivudine and zidovudine. interactions with: none known
Pregnancy category: N/A (Not indicated for Skin
Warning: HYPERSENSITIVITY REACTIONS, Basal cell carcinoma [3]
LACTIC ACIDOSIS and SEVERE use in females of reproductive potential)
Important contra-indications noted in the Eczema [2]
HEPATOMEGALY, and EXACERBATIONS OF Herpes simplex (<5%) [3]
HEPATITIS B prescribing guidelines for: pediatric patients
Warning: RISK OF OSTEOSARCOMA Herpes zoster [3]
Hypersensitivity [2]
Skin Malignancies [10]
Anaphylactoid reactions/Anaphylaxis (3%) Cardiovascular Psoriasis [13]
[3] Orthostatic hypotension (<4%) Rash (4%) [6]
Exanthems [2] Palpitation (5%) Sjögren’s syndrome [4]
Hypersensitivity (8–9%) [69] Tachycardia (2%) Squamous cell carcinoma [5]
Lipoatrophy [2] Central Nervous System Vasculitis [2]
Rash (5–7%) [17] Headache (8%) Mucosal
Stevens-Johnson syndrome [2] Vertigo (dizziness) (2–10%) Stomatitis [3]
Toxic epidermal necrolysis [2] Neuromuscular/Skeletal Cardiovascular
Cardiovascular Asthenia (fatigue) (3%) Hypertension (7%) [4]
Myocardial infarction [9] Gastrointestinal/Hepatic Hypotension [2]
Central Nervous System Abdominal pain (3%) Central Nervous System
Abnormal dreams (10%) [2] Nausea (8%) Fever (5%) [2]
Anxiety (5%) Endocrine/Metabolic Headache (5–18%) [6]
Chills (6%) Hypercalcemia (3%) [2] Vertigo (dizziness) (9%) [3]
Depression (6%) Hyperuricemia (25%)
Fever (6%) [2] Neuromuscular/Skeletal
Headache (7–13%) [4] Genitourinary Asthenia (fatigue) [2]
Insomnia [2] Hypercalciuria (11%) Back pain (7%) [2]
Migraine (7%) Urolithiasis (2%) Pain in extremities (3%)
Neuropsychiatric disturbances [3] Local Gastrointestinal/Hepatic
Sleep related disorder (10%) Injection-site edema (10%) Abdominal pain (5%)
Vertigo (dizziness) (6%) [3] Injection-site erythema (58%) Diarrhea (5%) [3]
Neuromuscular/Skeletal Injection-site pain (9%) Dyspepsia (6%)
Asthenia (fatigue) (7–12%) [2] Gastroenteritis [5]
Bone or joint pain (5–6%) Nausea (5%) [2]
Myalgia/Myopathy (5–6%) [2] ABARELIX Vomiting [2]
Gastrointestinal/Hepatic Respiratory
Abdominal pain (6%) See: www.drugeruptiondata.com/drug/id/1011 Bronchitis (<13%) [4]
Diarrhea (7%) [2] Cough (5–8%)
Gastritis (6%) Influenza (5–13%) [2]
Hepatotoxicity [4] Nasopharyngitis (12%) [6]
Nausea (7–19%) [5] Pharyngitis [3]
Vomiting (2–10%) Pneumonia (<5%) [7]
Pulmonary toxicity [2]
Respiratory Rhinitis (<5%) [2]
Bronchitis (4%) Sinusitis (5–13%) [3]
Cough [2] Tuberculosis [2]
Pneumonia (4%) Upper respiratory tract infection (>10%)
Endocrine/Metabolic [9]
ALT increased (6%) Genitourinary
AST increased (6%) Urinary tract infection (5–13%) [10]
Hyperamylasemia (2–4%)
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Local Hematologic Genitourinary

Infusion-related reactions [4] Anemia (25%) [3] Nocturia (6%)
Infusion-site reactions (9%) [5] Leukopenia (17%) [4] Urinary frequency (7%)
Injection-site erythema [3] Neutropenia (37%) [5] Urinary tract infection (12%) [2]
Injection-site hematoma [2] Thrombocytopenia (20%) [3] Hematologic
Injection-site pain [3] Other Anemia [5]
Injection-site pruritus [2] Infection (31%) Thrombocytopenia [2]
Injection-site reactions (3%) [8]
Other
Other Adverse effects [7]
Adverse effects [24]
Death [2]
ABIRATERONE
Infection (36–54%) [25] Trade name: Zytiga (Janssen Biotech)
Indications: Metastatic castration-resistant
ACAMPROSATE
prostate cancer (in combination with prednisone) See: www.drugeruptiondata.com/drug/id/1047
ABCIXIMAB Class: CYP17 inhibitor, Enzyme inhibitor
Half-life: 12 hours
See: www.drugeruptiondata.com/drug/id/2 Clinically important, potentially hazardous
interactions with: atazanavir, carbamazepine, ACARBOSE
clarithromycin, CYP3A4 inhibitors or inducers,
Trade names: Glucobay (Bayer), Precose
ABEMACICLIB * indinavir, itraconazole, ketoconazole, nefazodone,
nelfinavir, phenobarbital, phenytoin, rifabutin, (Bayer)
rifampin, rifapentine, ritonavir, saquinavir, Indications: Non-insulin dependent diabetes
Trade name: Verzenio (Lilly) Type II
Indications: Hormone receptor-positive, human telithromycin, thioridazine, voriconazole
Pregnancy category: X Class: Alpha-glucosidase inhibitor, Antidiabetic
epidermal growth factor 2-negative advanced or Half-life: 2 hours
metastatic breast cancer, either as monotherapy Important contra-indications noted in the
prescribing guidelines for: nursing mothers; Clinically important, potentially hazardous
or in combination with fulvestrant interactions with: alcohol, anabolic steroids,
Class: Kinase inhibitor pediatric patients
Note: Contra-indicated in women who are or beta blockers, cholestyramine, corticosteroids,
Half-life: 18 hours diazoxide, digoxin, diuretics, estrogens,
Clinically important, potentially hazardous may become pregnant.
hypoglycemic agents, MAO inhibitors, neomycin,
interactions with: grapefruit juice, orlistat, pancreatin, pegvisomant, pramlintide,
ketoconazole, strong CYP3A4 inducers and Skin progestogens, somatropin, testosterone
inhibitors Edema (27%) [19] Pregnancy category: B
Pregnancy category: N/A (Can cause fetal Hot flashes (19%) [3] Important contra-indications noted in the
harm) Cardiovascular prescribing guidelines for: nursing mothers;
Important contra-indications noted in the Arrhythmias (7%) pediatric patients
prescribing guidelines for: nursing mothers; Atrial fibrillation [3] Note: Contra-indicated in patients with diabetic
pediatric patients Cardiac failure (2%) ketoacidosis or cirrhosis; also in patients with
Cardiotoxicity [4] inflammatory bowel disease, colonic ulceration,
Hair Chest pain (4%) partial intestinal obstruction or in patients
Alopecia (12%) Hypertension (9%) [23] predisposed to intestinal obstruction.
Mucosal Tachycardia [3]
Stomatitis (14%) Central Nervous System Skin
Xerostomia (17%) Headache [2] AGEP [2]
Central Nervous System Neuromuscular/Skeletal Gastrointestinal/Hepatic
Anorexia [3] Arthralgia [5] Abdominal distension [2]
Dysgeusia (taste perversion) (12%) Asthenia (fatigue) [11] Abdominal pain (19%)
Fever (11%) Back pain [4] Diarrhea (31%)
Headache (20%) Bone or joint pain (30%) [8] Flatulence (74%) [3]
Vertigo (dizziness) (11%) Myalgia/Myopathy (26%) Hepatitis [2]
Neuromuscular/Skeletal Pain in extremities [2] Hepatotoxicity [3]
Arthralgia (15%) Rhabdomyolysis [2] Pneumatosis intestinalis [8]
Asthenia (fatigue) (65%) [7] Gastrointestinal/Hepatic Other
Gastrointestinal/Hepatic Constipation [7] Adverse effects [5]
Abdominal pain (39%) [2] Diarrhea (18%) [5]
Constipation (17%) Dyspepsia (6%)
Diarrhea (90%) [7] Hepatotoxicity (2%) [12]
Nausea [8]
ACEBUTOLOL
Nausea (64%) [7]
Vomiting (35%) [4] Respiratory See: www.drugeruptiondata.com/drug/id/4
Respiratory Cough (11%)
Cough (19%) Dyspnea [2]
Endocrine/Metabolic
Upper respiratory tract infection (5%) [2] ACECLOFENAC
ALT increased (31%) Endocrine/Metabolic
Appetite decreased (45%) [2] ALT increased (11%) [5] See: www.drugeruptiondata.com/drug/id/1261
AST increased (30%) AST increased (31%) [3]
Dehydration (10%) Hypercholesterolemia [2]
Serum creatinine increased (13%) [3] Hypertriglyceridemia (63%)
Weight loss (14%) [2] Hypokalemia [21]
2 Litt’s Drug Eruption & Reaction Manual B 2018 by Taylor & Francis Group, LLC
Litt’s Drug Eruption & Reaction Manual ACIPIMOX
Headache [IV] (10%) [5] Vomiting [2]

ACEMETACIN Insomnia [IV] (7%) Endocrine/Metabolic
Somnolence (drowsiness) [8] Acidosis [3]
See: www.drugeruptiondata.com/drug/id/1691 Vertigo (dizziness) [15] Libido decreased [2]
Neuromuscular/Skeletal Weight loss [2]
Rhabdomyolysis [4] Renal
ACENOCOUMAROL Gastrointestinal/Hepatic Nephrolithiasis [3]
See: www.drugeruptiondata.com/drug/id/1276 Abdominal distension [2] Ocular
Abdominal pain [IV] [3] Choroidal detachment [2]
Constipation [IV] (>5%) [7] Corneal edema [2]
Diarrhea [IV] [2] Glaucoma [3]
ACETAMINOPHEN Hepatotoxicity [70] Myopia [2]
Nausea [IV] (34%) [18]
Synonyms: APAP; paracetamol Pancreatitis [6]
Trade names: Anacin-3 (Wyeth), Darvocet-N Vomiting (15%) [16]
(aaiPharma), Excedrin (Bristol-Myers Squibb),
Respiratory
ACETOHEXAMIDE
Lorcet (Forest), Panadol (GSK), Percocet (Endo),
Tylenol (Ortho-McNeil), Vicodin (AbbVie) Asthma [3] See: www.drugeruptiondata.com/drug/id/7
Indications: Pain, fever Pulmonary toxicity [IV] (>5%)
Class: Analgesic, non-narcotic Endocrine/Metabolic
Half-life: <3 hours
Clinically important, potentially hazardous
Acidosis [3] ACETYLCHOLINE
Renal
interactions with: alcohol, anticonvulsants, Nephrotoxicity [9] See: www.drugeruptiondata.com/drug/id/2445
barbiturates, busulfan, carbamazepine, Renal failure [3]
cholestyramine, conivaptan, coumarins,
didanosine, dong quai, exenatide, imatinib, Hematologic
isoniazid, liraglutide, melatonin, metoclopramide, Thrombocytopenia [2] ACETYLCYSTEINE
metyrapone, PEG-interferon, pramlintide, Other
probenecid, St John’s wort Adverse effects [16] Synonyms: N-acetylcysteine; L-Cysteine; NAC
Pregnancy category: C Death [6] Indications: Emphysema, bronchitis,
Important contra-indications noted in the tuberculosis, bronchiectasis, tracheostomy care,
prescribing guidelines for: nursing mothers antidote for acetaminophen toxicity
Note: Acetaminophen is the active metabolite of Class: Antidote, Antioxidant
phenacetin. [IV] = intravenous. As a general point
ACETAZOLAMIDE Half-life: N/A
most reactions listed are those that have Clinically important, potentially hazardous
Trade name: Diamox (Duramed) interactions with: carbamazepine, nitroglycerin
developed following the normal prescribing doses Indications: Epilepsy, glaucoma
for acetaminophen and the overdosing, poisoning, Pregnancy category: B
Class: Carbonic anhydrase inhibitor, Diuretic Note: As an antidote, it is difficult to differentiate
and other toxicities that have been reported have Half-life: 26 hours
been excluded. side effects due to the drug from those due to the
Clinically important, potentially hazardous effects of the poison.
interactions with: arsenic, aspirin, ephedra,
Skin indacaterol, lisdexamfetamine, lithium,
AGEP [10] metformin, mivacurium, triamcinolone Skin
Anaphylactoid reactions/Anaphylaxis [19] Pregnancy category: C Anaphylactoid reactions/Anaphylaxis (8–
Angioedema [8] Important contra-indications noted in the 18%) [13]
Dermatitis [3] prescribing guidelines for: the elderly; nursing Angioedema [6]
Erythema [3] mothers; pediatric patients Pruritus (<4%) [3]
Erythema multiforme [3] Note: Acetazolamide is a sulfonamide and can be Rash (2–4%) [4]
Exanthems [7] absorbed systemically. Sulfonamides can produce Urticaria (6–8%)
Exfoliative dermatitis [2] severe, possibly fatal, reactions such as toxic Cardiovascular
Fixed eruption [41] epidermal necrolysis and Stevens-Johnson Flushing (<8%) [2]
Hyperhidrosis [2] syndrome. Tachycardia (<4%)
Hypersensitivity [12] Central Nervous System
Neutrophilic eccrine hidradenitis [2] Skin Seizures [2]
Pemphigus [2] AGEP [2]
Pruritus [5] Gastrointestinal/Hepatic
Anaphylactoid reactions/Anaphylaxis [3] Diarrhea [2]
Purpura [6] Exanthems [2]
Rash [IV] [2] Nausea (<6%) [3]
Pemphigus [2] Vomiting (2–10%) [2]
Stevens-Johnson syndrome [10] Stevens-Johnson syndrome [6]
Toxic epidermal necrolysis [13] Toxic epidermal necrolysis [2] Other
Urticaria [17] Adverse effects [2]
Vasculitis [4] Central Nervous System Death [2]
Depression [2]
Mucosal Dysgeusia (taste perversion) (>10%) [8]
Xerostomia [3] Paresthesias [6]
Cardiovascular Neuromuscular/Skeletal
ACIPIMOX
Hypertension [IV] [3] Asthenia (fatigue) [4]
Hypotension [2] See: www.drugeruptiondata.com/drug/id/1343
Gastrointestinal/Hepatic
Central Nervous System Diarrhea [2]
Agitation [IV] (>5%) Dyspepsia [2]
Fever [IV] (5%) Nausea [2]
ACITRETIN Over 100 updates per week on www.drugeruptiondata.com
Gingivitis (<10%) Other

ACITRETIN Mucocutaneous reactions [3] Adverse effects [9]
Sialorrhea (<10%) Dipsia (thirst) (<10%)
Trade names: Neotigason (Actavis), Soriatane Stomatitis (<10%) [2] Infection [2]
(Stiefel) Tongue disorder (<10%) Side effects [4]
Indications: Psoriasis Ulcerative stomatitis (<10%) Teratogenicity [7]
Class: Retinoid Xerostomia (1060%) [7]
Half-life: 49 hours
Clinically important, potentially hazardous Cardiovascular
interactions with: alcohol, bexarotene, Capillary leak syndrome [2] ACLIDINIUM
chloroquine, cholestyramine, corticosteroids, Central Nervous System
coumarins, danazol, demeclocycline, doxycycline, Anorexia (<10%) See: www.drugeruptiondata.com/drug/id/3007
ethanolamine, isotretinoin, lithium, lymecycline, Depression (<10%) [4]
medroxyprogesterone, methotrexate, Dysgeusia (taste perversion) (<10%)
minocycline, oxytetracycline, phenytoin, Headache (<10%) [2] ACYCLOVIR
progestins, St John’s wort, tetracycline, Hyperesthesia (1025%)
tigecycline, vitamin A Insomnia (<10%) Synonyms: aciclovir; ACV; acycloguanosine
Pregnancy category: X Neurotoxicity [3] Trade names: Sitavig (Cipher), Zovirax (GSK)
Important contra-indications noted in the Pain (<10%) Indications: Herpes simplex, herpes zoster
prescribing guidelines for: nursing mothers; Paralysis (facial) (<10%) Class: Antiviral, Antiviral, topical, Guanine
pediatric patients Paresthesias (1025%) [2] nucleoside analog
Note: Oral retinoids can cause birth defects, and Pseudotumor cerebri [5] Half-life: 3 hours (adults)
women should avoid acitretin when pregnant or Rigors (10–25%) [2] Clinically important, potentially hazardous
trying to conceive. Somnolence (drowsiness) (<10%) interactions with: cobicistat/elvitegravir/
Warning: PREGNANCY Stroke [2] emtricitabine/tenofovir alafenamide, cobicistat/
Suicidal ideation [2] elvitegravir/emtricitabine/tenofovir disoproxil,
Skin Neuromuscular/Skeletal meperidine, tenofovir disoproxil
Angioedema [2] Arthralgia (10–25%) [2] Pregnancy category: B
Atrophy (1025%) Asthenia (fatigue) (<10%) [3] Important contra-indications noted in the
Bromhidrosis (<10%) Back pain (<10%) prescribing guidelines for: nursing mothers
Bullous dermatitis (<10%) Bone or joint pain [2]
Clammy skin (<10%) Hyperostosis [10] Skin
Dermatitis (<10%) Myalgia/Myopathy [4] Acneform eruption (<3%)
Diaphoresis (<10%) [2] Osteoporosis [2] Dermatitis [12]
Edema (<10%) Gastrointestinal/Hepatic Exanthems (<5%) [5]
Erythema (18%) Abdominal pain (<10%) Facial edema (3–5%)
Erythroderma [3] Diarrhea (<10%) [2] Peripheral edema [2]
Exanthems (10–25%) [2] Hepatitis [5] Pruritus (<10%)
Exfoliative dermatitis (2550%) [3] Hepatotoxicity [8] Radiation recall dermatitis [2]
Fissures (<10%) Nausea (<10%) [2] Rash (<3%) [3]
Hot flashes (<10%) Pancreatitis [3] Urticaria (<5%) [4]
Hyperhidrosis (<10%) [2] Vomiting [2] Hair
Palmar–plantar desquamation (2080%) [7] Alopecia (<3%)
Photosensitivity [3] Respiratory
Pigmentation [3] Laryngitis [2] Central Nervous System
Pruritus (1050%) [10] Rhinitis (25–50%) [2] Headache (2%) [4]
Psoriasis (aggravated) (<10%) Sinusitis (<10%) Neurotoxicity [8]
Purpura (<10%) Endocrine/Metabolic Neuromuscular/Skeletal
Rash (>10%) GGT increased [2] Asthenia (fatigue) (12%)
Seborrhea (<10%) Hyperbilirubinemia [2] Gastrointestinal/Hepatic
Stickiness (350%) [7] Hypercholesterolemia (25–50%) [3] Diarrhea (2–3%)
Sunburn (<10%) Hyperlipidemia [5] Nausea (2–5%) [3]
Toxicity [3] Hypertriglyceridemia (50–75%) [4] Vomiting (3%)
Ulcerations (<10%) Genitourinary
Xerosis (2550%) [14] Renal
Vulvovaginal candidiasis [2] Nephrotoxicity [12]
Hair Otic Renal failure [4]
Alopecia (1075%) [21] Ear pain (<10%)
Curly hair [3] Ocular
Tinnitus (<10%) Hallucinations, visual [2]
Hair changes (<10%)
Hair pigmentation [2] Ocular Periorbital edema (3–5%)
Blepharitis (<10%) Local
Nails Cataract (<10%)
Brittle nails [3] Injection-site inflammation (>10%)
Conjunctivitis (<10%) [2] Injection-site thrombophlebitis (9%)
Nail changes (2550%) Diplopia (<10%)
Paronychia (1025%) [6] Night blindness (<10%) [2] Other
Pyogenic granuloma (<10%) [4] Ocular adverse effects [2] Adverse effects [2]
Mucosal Ocular itching [2]
Cheilitis (>75%) [14] Ocular pain (<10%)
Dry mucous membranes [4] Photophobia (<10%) [2]
Epistaxis (nosebleed) (10–25%) [2] Vision blurred (<10%)
Gingival bleeding (<10%) Xerophthalmia (10–25%) [3]
Litt’s Drug Eruption & Reaction Manual ADEFOVIR
Chest pain (<5%) Sepsis [2]

ADALIMUMAB Congestive heart failure (<5%) Ocular
Hypertension (<5%) Cataract (<5%)
Trade names: Amjevita (Amgen), Humira Myocardial infarction (<5%)
(AbbVie) Optic neuritis [5]
Palpitation [2] Uveitis [4]
Indications: Rheumatoid arthritis, polyarticular Pericarditis (<5%)
juvenile idiopathic arthritis, psoriatic arthritis, Tachycardia (<5%) Local
ankylosing spondylitis, Crohn’s disease, ulcerative Thromboembolism [2] Injection-site edema (15%) [2]
colitis, psoriasis Injection-site erythema (15%) [3]
Class: Cytokine inhibitor, Disease-modifying Central Nervous System Injection-site pain (12%)
antirheumatic drug (DMARD), Monoclonal Aseptic meningitis [2] Injection-site reactions [26]
antibody, TNF inhibitor Confusion (<5%)
Encephalitis [2] Other
Half-life: 1020 days Adverse effects [45]
Clinically important, potentially hazardous Fever (<5%) [3]
Guillain–Barré syndrome [5] Death [8]
interactions with: abatacept, anakinra, live Infection (5%) [70]
vaccines Headache (12%) [6]
Leukoencephalopathy [3] Side effects [2]
Pregnancy category: B
Important contra-indications noted in the Multiple sclerosis (<5%) [3]
prescribing guidelines for: nursing mothers Neurotoxicity [3]
Note: TNF inhibitors should be used in patients Paresthesias (<5%) [2] ADAPALENE
with heart failure only after consideration of other Syncope (<5%)
treatment options. TNF inhibitors are contra- Tremor (<5%) Trade names: Differin (Galderma), Epiduo
indicated in patients with a personal or family Vertigo (dizziness) [2] (Galderma)
history of multiple sclerosis or demyelinating Neuromuscular/Skeletal Indications: Acne vulgaris
disease. TNF inhibitors should not be Arthralgia (<5%) [6] Class: Retinoid
administered to patients with moderate to severe Asthenia (fatigue) [2] Half-life: N/A
heart failure (New York Heart Association Back pain (6%) [3] Clinically important, potentially hazardous
Functional Class III/IV). Tuberculous arthritis [2] interactions with: resorcinol, salicylates
Warning: SERIOUS INFECTIONS AND Pregnancy category: C
Gastrointestinal/Hepatic Important contra-indications noted in the
MALIGNANCY Abdominal pain (7%) [2] prescribing guidelines for: nursing mothers;
Cholecystitis (<5%) pediatric patients
Skin Colitis [2] Note: Epiduo is adapalene and benzoyl peroxide.
Acneform eruption [3] Esophagitis (<5%)
Angioedema [3] Gastroenteritis (<5%)
Carcinoma [2] Hepatitis [7] Skin
Cellulitis (<5%) [2] Hepatotoxicity [10] Burning (38%) [7]
Dermatomyositis [5] Nausea (9%) [2] Erythema (38%) [9]
Eczema [2] Vomiting (<5%) Pruritus (>10%) [11]
Erysipelas (<5%) Scaling (44%) [6]
Respiratory Stinging (38%) [3]
Granulomatous reaction [5] Asthma (<5%)
Henoch–Schönlein purpura [2] Xerosis (45%) [10]
Bronchitis [2]
Herpes zoster [10] Bronchospasm (<5%) Other
Hidradenitis [2] Dyspnea (<5%) Adverse effects [3]
Hypersensitivity [3] Flu-like syndrome (7%)
Lesions [2] Nasopharyngitis [4]
Lichenoid eruption [5] Pleural effusion (<5%) ADEFOVIR
Lupus erythematosus [16] Pneumonia (<5%) [6]
Lupus syndrome [3] Pneumonitis [3] Trade name: Hepsera (Gilead)
Lymphoma [8] Pulmonary fibrosis [3] Indications: HIV infection, hepatitis B infection
Malignancies [4] Pulmonary toxicity [7] Class: Antiretroviral, Nucleotide analog reverse
Melanoma [6] Sinusitis (11%) [2] transcriptase inhibitor
Neoplasms [2] Tuberculosis [9] Half-life: 1618 hours
Palmoplantar pustulosis [3] Upper respiratory tract infection (17%) [8] Clinically important, potentially hazardous
Peripheral edema (<5%) interactions with: amikacin, amphotericin B,
Pruritus [6] Endocrine/Metabolic
Creatine phosphokinase increased (<5%) cobicistat/elvitegravir/emtricitabine/tenofovir
Psoriasis [39] disoproxil, delavirdine, drugs causing kidney
Rash (12%) [4] Hypercholesterolemia (6%)
toxicity, foscarnet, gentamicin, hydroxyurea,
Sarcoidosis [8] Genitourinary pentamidine, tenofovir disoproxil, tobramycin
Squamous cell carcinoma [5] Cystitis (<5%) Pregnancy category: C
Stevens-Johnson syndrome [2] Hematuria (5%) Important contra-indications noted in the
Urticaria [3] Pelvic pain (<5%) prescribing guidelines for: the elderly; nursing
Vasculitis [9] Urinary tract infection (8%) mothers; pediatric patients
Vitiligo [2] Renal Warning: SEVERE ACUTE EXACERBATIONS
Hair Nephrotoxicity [2] OF HEPATITIS, NEPHROTOXICITY, HIV
Alopecia [5] Hematologic RESISTANCE, LACTIC ACIDOSIS AND SEVERE
Alopecia areata [7] Agranulocytosis (<5%) HEPATOMEGALY WITH STEATOSIS
Alopecia universalis [2] Eosinophilia [3]
Cardiovascular Hemolytic anemia [2] Skin
Arrhythmias (<5%) Leukopenia (<5%) Pruritus (<10%)
Cardiac arrest (<5%) Pancytopenia [2] Rash (<10%)
ADEFOVIR See all our books at www.crcpress.com
Central Nervous System Other Hypokalemia (10%) [3]

Headache (9%) [2] Adverse effects [2] Genitourinary
Pain [2] Urinary tract infection (9%)
Neuromuscular/Skeletal Hematologic
Asthenia (fatigue) (13%) [3] ADO-TRASTUZUMAB Anemia (14%) [6]
Back pain (<10%) Febrile neutropenia [3]
Osteomalacia [6] EMTANSINE Hemorrhage (32%) [2]
Gastrointestinal/Hepatic Neutropenia (7%) [4]
Synonym: T-DM1
Abdominal pain (9%) Thrombocytopenia (31%) [23]
Trade name: Kadcyla (Genentech)
Diarrhea (3%) Indications: HER2-positive, metastatic breast Ocular
Dyspepsia (3%) cancer in patients who previously received Conjunctivitis (4%)
Flatulence (4%) trastuzumab and a taxane, separately or in Lacrimation (3%)
Hepatotoxicity (<25%) combination Vision blurred (5%)
Nausea (5%) Class: Antibody drug conjugate (ADC), HER2- Xerophthalmia (4%)
Vomiting (<10%) targeted antibody-drug conjugate Other
Respiratory Half-life: 4 days Adverse effects [5]
Cough (6–8%) Clinically important, potentially hazardous Death [3]
Rhinitis (<5%) interactions with: none known
Endocrine/Metabolic Pregnancy category: D
Important contra-indications noted in the
Hypophosphatemia [5]
prescribing guidelines for: nursing mothers; AFAMELANOTIDE
Genitourinary pediatric patients
Hematuria (11%) See: www.drugeruptiondata.com/drug/id/1315
Warning: HEPATOTOXICITY, CARDIAC
Renal TOXICITY, EMBRYO-FETAL TOXICITY
Fanconi syndrome [11]
Nephrotoxicity [14] Skin AFATINIB
Hypersensitivity (2%)
Trade name: Gilotrif (Boehringer Ingelheim)
Peripheral edema (7%)
Indications: Metastatic non-small cell lung cancer
ADENOSINE Pruritus (6%)
in patients whose tumors have epidermal growth
Rash (12%)
factor receptor exon 19 deletions or exon 21
Synonym: ATP Telangiectasia [2]
(L858R) substitution mutations, metastatic
Trade names: Adenocard (Astellas), Adenocur Mucosal squamous non-small cell lung cancer progressing
(Sanofi-Aventis) Epistaxis (nosebleed) (23%) following platinium-based chemotherapy
Indications: Paroxysmal supraventricular Stomatitis (14%) Class: Tyrosine kinase inhibitor
tachycardia, varicose vein complications with Xerostomia (17%) Half-life: 37 hours
stasis dermatitis
Cardiovascular Clinically important, potentially hazardous
Class: Antiarrhythmic class IV, Neurotransmitter
Cardiotoxicity [2] interactions with: amiodarone, carbamazepine,
Half-life: <10 seconds
Hypertension (5%) cyclosporine, erythromycin, itraconazole,
ketoconazole, nelfinavir, P-glycoprotein inhibitors,
interactions with: aminophylline, Central Nervous System
phenobarbital, phenytoin, quinidine, rifampin,
antiarrhythmics, beta blockers, bupivacaine, Chills (8%)
ritonavir, saquinavir, St John’s wort, tacrolimus,
carbamazepine, dipyridamole, levobupivacaine, Dysgeusia (taste perversion) (8%)
verapamil
nicotine, prilocaine, QT prolonging agents, Fever (19%) [2]
Pregnancy category: D
ropivacaine Headache (28%) [4]
Pregnancy category: C Insomnia (12%)
prescribing guidelines for: nursing mothers;
Important contra-indications noted in the Peripheral neuropathy (21%)
pediatric patients
prescribing guidelines for: pediatric patients Vertigo (dizziness) (10%)
Neuromuscular/Skeletal
Cardiovascular Skin
Arthralgia (19%) [3]
Arrhythmias [2] Acneform eruption [25]
Asthenia (fatigue) (18–36%) [12]
Atrial fibrillation [6] Fissures [2]
Bone or joint pain (36%)
Chest pain [5] Hand–foot syndrome [2]
Myalgia/Myopathy (14%)
Coronary vasospasm [2] Pruritus [2]
Gastrointestinal/Hepatic Rash [49]
Flushing (18–44%) Abdominal pain (19%)
Torsades de pointes [2] Toxicity [3]
Constipation (27%) [3] Xerosis [6]
Central Nervous System Diarrhea (24%) [5]
Headache (2–18%) [2]
Nails
Dyspepsia (9%)
Vertigo (dizziness) (2–12%) Nail changes [2]
Hepatotoxicity [14]
Paronychia (58%) [10]
Neuromuscular/Skeletal Nausea (40%) [9]
Jaw pain (<15%) Vomiting (19%) Mucosal
Epistaxis (nosebleed) [3]
Mucosal inflammation [7]
Abdominal pain (13%) Cough (18%)
Mucositis [10]
Dyspnea (12%)
Respiratory Rhinorrhea (11%)
Pneumonia [3]
Cough (6–8%) Stomatitis (71%) [19]
Dyspnea [3] Endocrine/Metabolic
Central Nervous System
Respiratory distress (11%) ALP increased (5%)
Anorexia [3]
ALT increased (82%) [3]
Fever (12%)
AST increased (98%) [6]
Litt’s Drug Eruption & Reaction Manual ALBIGLUTIDE
Neuromuscular/Skeletal Gastrointestinal perforation [4] Gastrointestinal/Hepatic

Asthenia (fatigue) [17] Respiratory Abdominal pain (<7%) [7]
Gastrointestinal/Hepatic Dysphonia [5] Hepatitis [4]
Diarrhea (96%) [65] Dyspnea [2] Nausea (4–6%) [3]
Dysphagia [2] Pulmonary embolism [2] Vomiting (4–6%) [2]
Hepatotoxicity (10%) [5] Endocrine/Metabolic Other
Nausea [15] Weight loss [2] Adverse effects [5]
Vomiting [10]
Renal
Respiratory Proteinuria [8]
Dyspnea [3]
Hematologic
ALBIGLUTIDE
Pneumonitis [2]
Pulmonary toxicity [5] Hemorrhage [3] Trade name: Tanzeum (GSK)
Neutropenia [10] Indications: To improve glycemic control in
Endocrine/Metabolic
ALT increased [2] Ocular adults with Type II diabetes mellitus
Appetite decreased (29%) [5] Cataract (7%) [2] Class: Glucagon-like peptide-1 (GLP-1) receptor
Dehydration [3] Conjunctival hemorrhage (25%) [2] agonist
Hypokalemia [2] Conjunctival hyperemia (4%) Half-life: 5 days
Corneal erosion (4%) Clinically important, potentially hazardous
Hematologic Intraocular pressure increased (5%) [2] interactions with: none known
Anemia [3] Lacrimation (3%) Pregnancy category: C
Febrile neutropenia [2] Ocular adverse effects [3] Important contra-indications noted in the
Leukopenia [2] Ocular pain (3–9%) prescribing guidelines for: nursing mothers;
Neutropenia [6] Vision blurred (2%) pediatric patients
Thrombocytopenia [2] Vitreous detachment (6%) Note: Contra-indicated in patients with a
Other Vitreous floaters (6%) personal or family history of medullary thyroid
Adverse effects [7] Local carcinoma or in patients with multiple endocrine
Death [4] Injection-site pain (3%) neoplasia syndrome Type 2.
Warning: RISK OF THYROID C-CELL TUMORS
Other
Adverse effects [2]
AFLIBERCEPT Death [2] Central Nervous System
Infection [2] Headache [4]
Synonym: ziv-aflibercept Vertigo (dizziness) [2]
Trade names: Eylea (Regeneron), Zaltrap Neuromuscular/Skeletal
(Sanofi-Aventis) Arthralgia (7%)
Indications: Neovascular (wet) age-related AGALSIDASE Back pain (7%) [2]
macular degeneration (Eylea), metastatic
colorectal cancer (Zaltrap) in combination with See: www.drugeruptiondata.com/drug/id/993 Gastrointestinal/Hepatic
FOLFIRI (fluorouracil, leucovorin and irinotecan) Constipation [2]
Class: Fusion protein Diarrhea (13%) [15]
Half-life: terminal 5–6 days ALBENDAZOLE Dyspepsia (3%)
Gastroesophageal reflux (4%)
interactions with: none known Trade name: Albenza (GSK) Nausea (11%) [20]
Pregnancy category: C Indications: Nematode infections, hydatid cyst Pancreatitis [4]
Important contra-indications noted in the disease Vomiting (4%) [15]
prescribing guidelines for: nursing mothers; Class: Anthelmintic Respiratory
pediatric patients Half-life: 812 hours Cough (7%)
Note: Eylea: Contra-indicated in patients with Clinically important, potentially hazardous Influenza (5%)
ocular or periocular infection or active intraocular interactions with: antimalarials, conivaptan, Nasopharyngitis [3]
inflammation. dexamethasone, high fat foods Pneumonia (2%)
Warning: Zaltrap: HEMORRHAGE, Pregnancy category: C Sinusitis (6%)
GASTROINTESTINAL PERFORATION, Important contra-indications noted in the Upper respiratory tract infection (14%) [4]
COMPROMISED WOUND HEALING prescribing guidelines for: nursing mothers Endocrine/Metabolic
GGT increased (2%)
Mucosal Skin Hypoglycemia (2%) [5]
Epistaxis (nosebleed) [3] Fixed eruption [2] Local
Stomatitis [6] Pruritus [4] Injection-site hematoma (2%)
Cardiovascular Urticaria [2] Injection-site reactions (11%) [15]
Hypertension [12] Hair Other
Myocardial infarction (<2%) Alopecia (reversible) (<2%) [4] Adverse effects [4]
Venous thromboembolism [2] Central Nervous System
Central Nervous System Fever (<2%)
Anorexia [2] Headache (<11%) [5]
Headache [2] Intracranial pressure increased (<2%)
Stroke (<2%) Psychosis [2]
Neuromuscular/Skeletal Vertigo (dizziness) (<2%) [2]
Asthenia (fatigue) [6] Neuromuscular/Skeletal
Gastrointestinal/Hepatic Dystonia [3]
Diarrhea [5]
ALBUTEROL Over 100 updates per week on www.drugeruptiondata.com
busulfan, captopril, carboplatin, carmustine, Depression [3]

ALBUTEROL chlorambucil, ciclesonide, cilazapril, cisplatin, Dysgeusia (taste perversion) (7%)
corticosteroids, cyclophosphamide, cytarabine, Fever (29%) [8]
Synonym: salbutamol dacarbazine, dactinomycin, daunorubicin, Neurotoxicity [3]
Trade names: AccuNeb (Mylan Specialty), docetaxel, doxorubicin, enalapril, estramustine, Pain (12%)
Combivent (Boehringer Ingelheim), Duoneb etoposide, fludarabine, fluorouracil, fosinopril, Rigors [3]
(Mylan Specialty), Proventil (Schering), Ventolin gemcitabine, gentamicin, hydroxyurea, idarubicin, Somnolence (drowsiness) (22%)
(GSK), Volmax (Muro) ifosfamide, indomethacin, interferon alfa, Vertigo (dizziness) (11%)
Indications: Bronchospasm associated with irbesartan, kanamycin, levamisole, lisinopril,
asthma Neuromuscular/Skeletal
lomustine, mechlorethamine, melphalan, Asthenia (fatigue) (23–27%)
Class: Beta-2 adrenergic agonist, Bronchodilator, mercaptopurine, methotrexate, mitomycin,
Tocolytic Myalgia/Myopathy (6%)
mitotane, mitoxantrone, neomycin, olmesartan, Myasthenia gravis [2]
Half-life: 36 hours PEG-interferon, pentostatin, plicamycin,
Clinically important, potentially hazardous procarbazine, quinapril, ramipril, streptomycin, Gastrointestinal/Hepatic
interactions with: atomoxetine, epinephrine, streptozocin, thioguanine, thiotepa, tobramycin, Abdominal pain (11%)
insulin degludec, insulin detemir, insulin glargine, trandolapril, tretinoin, triamcinolone, uracil, Diarrhea (67%) [3]
insulin glulisine vinblastine, vincristine, vinorelbine Hepatotoxicity [2]
Pregnancy category: C Pregnancy category: C Nausea (35%) [9]
Important contra-indications noted in the Important contra-indications noted in the Vomiting (50%) [6]
prescribing guidelines for: nursing mothers prescribing guidelines for: nursing mothers; Respiratory
Note: Combivent is albuterol and ipratropium. pediatric patients Cough (11%)
Note: Contra-indicated in patients with Dyspnea (43%)
Skin significant cardiac, pulmonary, renal, hepatic, or Pulmonary toxicity (11–24%) [2]
Dermatitis [2] CNS impairment. Rhinitis (10%)
Diaphoresis (<10%) Warning: CAPILLARY LEAK SYNDROME Endocrine/Metabolic
Erythema (palmar) (with infusion) [2] Acidosis (12%)
Mucosal Skin ALP increased (10%)
Xerostomia (<10%) Angioedema [2] AST increased (23%)
Cardiovascular Dermatitis [2] Creatine phosphokinase increased (33%) [2]
Flushing (<10%) Edema (47%) [3] Hypocalcemia (11%)
Hypertension [2] Erythema (41%) [5] Hypomagnesemia [2]
Myocardial infarction [2] Erythema nodosum [3] Hypophosphatemia [2]
Palpitation [2] Erythroderma [4] Weight gain (16%)
Tachyarrhythmia [2] Exanthems [5] Weight loss [2]
Tachycardia [2] Exfoliative dermatitis (18%) Genitourinary
Linear IgA bullous dermatosis [4] Oliguria (63%)
Central Nervous System Necrosis [2]
Dysgeusia (taste perversion) (<10%) Pemphigus [2] Renal
Tremor [2] Peripheral edema (28%) Nephrotoxicity [4]
Respiratory Petechiae (4%) Hematologic
Dyspnea [2] Pruritus (24%) [7] Anemia (29%)
Psoriasis [4] Leukopenia (16%) [2]
Endocrine/Metabolic
Purpura (4%) Sepsis [3]
Acidosis [3]
Rash (42%) [2] Thrombocytopenia (37%) [2]
Other Scleroderma [2]
Adverse effects [2] Local
Toxic epidermal necrolysis [2]
Injection-site inflammation [2]
Toxicity [6]
Injection-site nodules [2]
Urticaria (2%) [3]
ALCAFTADINE Vitiligo [3]
Other
Xerosis (15%)
See: www.drugeruptiondata.com/drug/id/1851 Adverse effects [3]
Hair Death [5]
Alopecia [2]
Infection (13%) [2]
Mucosal
ALCLOMETASONE Oral mucosal eruption [2]
Stomatitis (22%)
See: www.drugeruptiondata.com/drug/id/1082 ALECTINIB
Cardiovascular
Arrhythmias (10%) Trade name: Alecensa (Genentech)
Capillary leak syndrome [12] Indications: Anaplastic lymphoma kinase-
ALDESLEUKIN Cardiotoxicity (11%) [2] positive, metastatic non-small cell lung cancer in
Hypotension (71%) [6] patients who have progressed on, or are
Synonyms: IL-2; interleukin-2 Supraventricular tachycardia (12%) intolerant to, crizotinib
Trade name: Proleukin (Chiron) Tachycardia (23%) Class: Kinase inhibitor
Indications: Metastatic renal cell carcinoma and Vascular leak syndrome [6] Half-life: 33 hours
metastatic melanoma Vasodilation (13%) Clinically important, potentially hazardous
Class: Biologic, Immunomodulator, Interleukin-2 interactions with: none known
Half-life: 685 minutes
Anorexia (20%)
Anxiety (12%)
interactions with: acebutolol, alfuzosin,
altretamine, amikacin, aminoglycosides,
Chills (52%)
antineoplastics, betamethasone, bleomycin,
Confusion (34%)
Litt’s Drug Eruption & Reaction Manual ALENDRONATE
Pregnancy category: N/A (Can cause fetal Pneumonia (16%) [3]

harm) ALEMTUZUMAB Pneumonitis [2]
Important contra-indications noted in the Respiratory tract infection [2]
prescribing guidelines for: nursing mothers; Trade names: Campath (Bayer), MabCampath Tuberculosis [2]
pediatric patients (Schering)
Indications: B-cell chronic lymphcyotic Endocrine/Metabolic
leukemia, non-Hodgkin’s lymphoma Hyperthyroidism [2]
Skin Class: Biologic, Immunosuppressant, Monoclonal Hypothyroidism [2]
Edema (30%) antibody Thyroid dysfunction [14]
Peripheral edema [5] Half-life: 12 days Renal
Photosensitivity (10%) [2] Clinically important, potentially hazardous Nephrotoxicity [2]
Rash (18%) [2] interactions with: none known Hematologic
Hair Pregnancy category: C Anemia (76%) [4]
Alopecia [2] Note: Prophylactic therapy against PCP Cytopenia [2]
Central Nervous System pneumonia and herpes viral infections is Hemolytic anemia [2]
Dysgeusia (taste perversion) [2] recommended upon initiation of therapy and for Hemotoxicity [4]
Headache (17%) [2] at least 2 months following last dose. Leukopenia [4]
Warning: CYTOPENIAS, INFUSION Lymphopenia (97%) [2]
Neuromuscular/Skeletal REACTIONS, and INFECTIONS
Asthenia (fatigue) (41%) [5] Neutropenia (77%) [7]
Back pain (12%) Sepsis [2]
Myalgia/Myopathy (29%) [6] Skin Thrombocytopenia (71%) [10]
Carcinoma [2] Local
Gastrointestinal/Hepatic Erythema (4%)
Constipation (34%) [7] Application-site reactions [2]
Herpes [2] Infusion-related reactions [10]
Diarrhea (16%) [2] Herpes simplex [2]
Nausea (18%) [3] Infusion-site reactions [6]
Herpes zoster [3] Injection-site pruritus (3040%)
Vomiting (12%) [2] Lymphoma [2] Injection-site reactions (90%) [5]
Respiratory Lymphoproliferative disease (6470%)
Cough (19%) Peripheral edema (13%) Other
Dyspnea (16%) Pruritus (14–24%) Adverse effects [6]
Pulmonary toxicity [3] Purpura (8%) Death [13]
Rash (13–40%) [5] Infection (43–74%) [51]
Endocrine/Metabolic
ALP increased (47%) [3] Thrombocytopenic purpura [10]
ALT increased (34%) [5] Urticaria (16–30%) [2]
AST increased (51%) [6] Mucosal ALENDRONATE
Creatine phosphokinase increased (43%) [6] Stomatitis (14%)
GGT increased [2] Trade names: Binosto (Mission), Fosamax
Cardiovascular (Merck)
Hyperbilirubinemia (39%) [5] Flushing [2]
Hyperglycemia (36%) Indications: Osteoporosis in postmenopausal
Hypertension (11–15%) women, Paget’s disease
Hypocalcemia (32%) Hypotension (15–32%) [2]
Hypokalemia (29%) Class: Bisphosphonate
Tachycardia (10%) Half-life: >10 years
Hyponatremia (20%)
Hypophosphatemia (21%) Central Nervous System Clinically important, potentially hazardous
Serum creatinine increased (28%) Anorexia (20%) interactions with: none known
Weight gain (11%) Anxiety (8%) Pregnancy category: C
Chills (53%) Important contra-indications noted in the
Hematologic Depression (7%) prescribing guidelines for: nursing mothers;
Anemia (56%) [2] Dysesthesia (15%) pediatric patients
Lymphopenia (22%) Fever (69–85%) [6]
Neutropenia [5] Guillain–Barré syndrome [2] Skin
Ocular Headache (13–24%) [3] Angioedema [2]
Visual disturbances (10%) Insomnia (10%) Erythema multiforme [2]
Other Intracranial hemorrhage [2] Hypersensitivity [3]
Adverse effects [2] Leukoencephalopathy [5] Rash [5]
Rigors (87%)
Tremor (3%) Mucosal
Vertigo (dizziness) (12%) Oral ulceration [9]
ALEFACEPT Neuromuscular/Skeletal Central Nervous System
Asthenia (fatigue) (22–34%) Headache [2]
See: www.drugeruptiondata.com/drug/id/939
Bone or joint pain (24%) Neuromuscular/Skeletal
Myalgia/Myopathy (11%) Arthralgia [6]
Gastrointestinal/Hepatic Bone or joint pain (<6%) [5]
Abdominal pain (11%) Fractures [20]
Diarrhea (10–22%) [2] Osteonecrosis [12]
Nausea (47–54%) [4] Gastrointestinal/Hepatic
Vomiting (33–41%) [2] Abdominal pain (<7%) [8]
Respiratory Dyspepsia [8]
Dyspnea (14–26%) Dysphagia [4]
Flu-like syndrome [2] Esophageal perforation [2]
Pharyngitis (12%) Esophagitis [12]
ALENDRONATE See all our books at www.crcpress.com
Hepatotoxicity [7] Gastrointestinal/Hepatic Nausea [2]

Nausea [7] Abdominal pain (<2%) Respiratory
Vomiting [4] Hepatotoxicity [2] Bronchitis (4%)
Endocrine/Metabolic Respiratory Cough (3%)
Hypocalcemia (18%) [5] Bronchitis (<2%) Influenza (6%) [4]
Renal Pharyngitis (<2%) Nasopharyngitis (11%) [8]
Nephrotoxicity [2] Sinusitis (<2%) Sinusitis (3%) [2]
Renal failure [2] Upper respiratory tract infection (3%) Upper respiratory tract infection [7]
Ocular Genitourinary Endocrine/Metabolic
Conjunctivitis [2] Ejaculatory dysfunction [3] ALT increased [3]
Ocular adverse effects [2] Erectile dysfunction [2] Creatine phosphokinase increased [3]
Ocular inflammation [2] Ocular Genitourinary
Scleritis [3] Floppy iris syndrome [4] Urinary tract infection (5%)
Uveitis [6] Other Ocular
Other Adverse effects [2] Ocular adverse effects [2]
Adverse effects [5] Local
Injection-site pain [2]
ALGLUCERASE Injection-site reactions (7%) [16]
ALFENTANIL Other
See: www.drugeruptiondata.com/drug/id/15 Allergic reactions (9%)
Death [2]
ALGLUCOSIDASE ALFA
ALFUZOSIN
Trade names: Uroxatral (Concordia), Xatral
See: www.drugeruptiondata.com/drug/id/1164 ALISKIREN
(Sanofi-Aventis) See: www.drugeruptiondata.com/drug/id/1225
Indications: Benign prostatic hyperplasia
Class: Adrenergic alpha-receptor antagonist
ALIROCUMAB
Half-life: 10 hours
Trade name: Praluent (Regeneron)
Indications: Adjunct to diet and statin therapy in
ALITRETINOIN
interactions with: ACE inhibitors, adrenergic hypercholesterolemia or clinical atherosclerotic
neurone blockers, alcohol, aldesleukin, Trade name: Panretin (Ligand)
cardiovascular disease where additional lowering Indications: Kaposi’s sarcoma cutaneous lesions
alprostadil, amitriptyline, angiotensin II receptor of low density lipoprotein cholesterol is required
antagonists, antipsychotics, anxiolytics and Class: Retinoid
Class: Monoclonal antibody, Proprotein Half-life: N/A
hypnotics, arsenic, atazanavir, atenolol, baclofen, convertase subtilisin kexin type 9 (PCSK9)
beta blockers, boceprevir, calcium channel Clinically important, potentially hazardous
inhibitor interactions with: ketoconazole, simvastatin,
blockers, cimetidine, citalopram, clonidine, Half-life: 17–20 days
conivaptan, corticosteroids, CYP3A4 inhibitors or vitamin A
Clinically important, potentially hazardous Pregnancy category: D
inducers, darunavir, dasabuvir/ombitasvir/ interactions with: none known
paritaprevir/ritonavir, dasatinib, deferasirox, Important contra-indications noted in the
Pregnancy category: N/A (No data available but prescribing guidelines for: the elderly; pediatric
degarelix, delavirdine, diazoxide, diltiazem, likely to cross the placenta in second and third
diuretics, estrogens, food, general anesthetics, patients
trimester) Note: Oral alitretinoin (Toctino) is not available in
hydralazine, indinavir, itraconazole, ketoconazole, Important contra-indications noted in the
lapatinib, levodopa, levofloxacin, lopinavir, MAO the USA.
prescribing guidelines for: pediatric patients
inhibitors, methyldopa, minoxidil, moxifloxacin,
moxisylyte, moxonidine, nelfinavir, nitrates, Skin
nitroprusside, NSAIDs, pazopanib, Skin Edema (38%)
phosphodiesterase 5 inhibitors, protease Hematoma (2%) Erythema [2]
inhibitors, QT prolonging agents, ritonavir, Cardiovascular Exfoliative dermatitis (39%)
sildenafil, St John’s wort, tadalafil, telaprevir, Cardiotoxicity [3] Pigmentation (3%)
telavancin, telithromycin, tipranavir, tizanidine, Myocardial infarction [3] Pruritus (811%)
vardenafil, voriconazole, vorinostat, ziprasidone Rash (2577%)
Pregnancy category: B Ulcerations (2%)
Cognitive impairment [2]
Important contra-indications noted in the Xerosis (10%)
Headache [4]
prescribing guidelines for: pediatric patients Hair
Neurotoxicity [4]
Stroke [2] Curly hair [2]
Cardiovascular Vertigo (dizziness) [6] Mucosal
Hypotension [2] Neuromuscular/Skeletal Mucocutaneous reactions [2]
Orthostatic hypotension [3]
Arthralgia [6] Cardiovascular
QT prolongation [2]
Asthenia (fatigue) [2] Flushing [2]
Central Nervous System Back pain [5]
Headache (3%) Bone or joint pain (2%) [2] Central Nervous System
Pain (<2%) Muscle spasm (3%) Depression [2]
Vertigo (dizziness) (6%) [19] Myalgia/Myopathy (4%) [7] Headache [7]
Paresthesias (322%)
Neuromuscular/Skeletal Gastrointestinal/Hepatic
Asthenia (fatigue) (3%) Diarrhea (5%) [3] Gastrointestinal/Hepatic
Hepatotoxicity (3%) Nausea [2]
Litt’s Drug Eruption & Reaction Manual ALPRAZOLAM
Endocrine/Metabolic Gastrointestinal/Hepatic
Creatine phosphokinase increased [2] Diarrhea [5] ALOGLIPTIN
Hypertriglyceridemia [2] Hepatotoxicity [7]
Nausea [3] Trade name: Nesina (Takeda)
Indications: Type II diabetes mellitus
Respiratory Class: Antidiabetic, Dipeptidyl peptidase-4 (DPP-
ALLOPURINOL Nasopharyngitis [2] 4) inhibitor
Upper respiratory tract infection [4] Half-life: 21 hours
Trade names: Duzallo (AstraZeneca), Zyloprim Endocrine/Metabolic Clinically important, potentially hazardous
(Prometheus) ALT increased [2] interactions with: none known
Indications: Gouty arthritis AST increased [3] Pregnancy category: B
Class: Purine analog, Xanthine oxidase inhibitor Important contra-indications noted in the
Half-life: <3 hours Renal
Nephrotoxicity [3] prescribing guidelines for: nursing mothers;
Clinically important, potentially hazardous pediatric patients
interactions with: acenocoumarol, amoxicillin, Other
ampicillin, ampicillin/sulbactam, azathioprine, Adverse effects [13]
benazepril, capecitabine, captopril, cilazapril, Allergic reactions (severe) [2] Skin
cyclopenthiazide, dicumarol, enalapril, fosinopril, Death [9] Hypersensitivity [2]
imidapril, lisinopril, mercaptopurine, Pruritus [2]
pantoprazole, quinapril, ramipril, trandolapril, Central Nervous System
uracil/tegafur, vidarabine, zofenopril Headache (4%) [8]
Pregnancy category: C
ALMOTRIPTAN Vertigo (dizziness) [3]
Note: HLA-B*5801 confers a risk of allopurinol- Trade names: Almogran (Almirall), Axert Neuromuscular/Skeletal
induced serious skin reactions like SJS/TEN and (Ortho-McNeil) Arthralgia [2]
DRESS. Indications: Migraine headaches
Duzallo is allopurinol and lesinurad (see separate Gastrointestinal/Hepatic
Class: 5-HT1 agonist, Serotonin receptor agonist, Constipation [2]
entry). Triptan Diarrhea [2]
Half-life: 34 hours Pancreatitis [3]
Skin Clinically important, potentially hazardous
AGEP [6] interactions with: conivaptan, darunavir, Respiratory
DRESS syndrome [45] delavirdine, dihydroergotamine, ergotamine, Nasopharyngitis (4%) [8]
Eosinophilic pustular folliculitis [2] indinavir, ketoconazole, methysergide, SNRIs, Upper respiratory tract infection (4%) [6]
Erythema multiforme [7] SSRIs, telithromycin, triptans, voriconazole Endocrine/Metabolic
Exanthems (<5%) [20] Pregnancy category: C Hypoglycemia [14]
Exfoliative dermatitis (>10%) [15] Important contra-indications noted in the Other
Fixed eruption [11] prescribing guidelines for: pediatric patients Adverse effects [6]
Granuloma annulare (disseminated) [2] Note: Contra-indicated in patients with history, Infection [3]
Hypersensitivity [49] symptoms, or signs of ischemic cardiac,
Lupus erythematosus [3] cerebrovascular, or peripheral vascular
Pityriasis rosea [2] syndromes, or with uncontrolled hypertension.
Pruritus [7] ALOSETRON
Purpura (>10%) [2] Cardiovascular
Rash (>10%) [11] See: www.drugeruptiondata.com/drug/id/18
Chest pain [3]
Stevens-Johnson syndrome (>10%) [53]
Toxic epidermal necrolysis [72] Central Nervous System
Toxic pustuloderma [3] Headache [2] ALPHA-LIPOIC ACID
Toxicity [2] Neurotoxicity [2]
Urticaria (>10%) [6] Paresthesias [4] See: www.drugeruptiondata.com/drug/id/1224
Vasculitis [7] Somnolence (drowsiness) [5]
Vertigo (dizziness) [6]
Hair
Alopecia (<10%) [2] Neuromuscular/Skeletal ALPRAZOLAM
Asthenia (fatigue) [4]
Mucosal
Oral ulceration [3] Gastrointestinal/Hepatic Trade name: Xanax (Pfizer)
Stomatitis [2] Nausea [6] Indications: Anxiety, depression, panic attacks
Vomiting [3] Class: Benzodiazepine
Cardiovascular Half-life: 1116 hours
Polyarteritis nodosa [3] Respiratory
Flu-like syndrome (12%) Clinically important, potentially hazardous
Central Nervous System Upper respiratory tract infection (20%) interactions with: alcohol, amprenavir,
Chills (<10%) aprepitant, boceprevir, clarithromycin, CNS
Fever [2] Other depressants, darunavir, delavirdine, digoxin,
Headache [3] Adverse effects [10] efavirenz, fluconazole, fluoxetine, fluvoxamine,
Vertigo (dizziness) [3] grapefruit juice, indinavir, itraconazole,
Neuromuscular/Skeletal ivermectin, kava, ketoconazole, posaconazole,
Arthralgia [3] propoxyphene, ritonavir, saquinavir, St John’s
Asthenia (fatigue) [2] wort, telaprevir, tipranavir
Back pain [2] Pregnancy category: D
Bone or joint pain [2] Important contra-indications noted in the
Joint disorder [2] prescribing guidelines for: the elderly; nursing
Myalgia/Myopathy [3] mothers; pediatric patients
ALPRAZOLAM Over 100 updates per week on www.drugeruptiondata.com
Skin Central Nervous System

Dermatitis (4%) [5] Fever (>10%) ALVIMOPAN
Diaphoresis (16%) Headache (>10%)
Edema (5%) Pain (>10%) See: www.drugeruptiondata.com/drug/id/1292
Photosensitivity [4] Vertigo (dizziness) (>10%)
Pruritus (<10%) [2] Neuromuscular/Skeletal
Rash (11%) [4] Back pain (<10%) AMANTADINE
Mucosal Gastrointestinal/Hepatic
Sialopenia (33%) See: www.drugeruptiondata.com/drug/id/23
Diarrhea (<10%)
Sialorrhea (4%)
Xerostomia (15%) [6] Respiratory
Cardiovascular
Apnea (>10%)
Cough (<10%)
AMBRISENTAN
Hypotension (<10%) Flu-like syndrome (<10%) Trade names: Letairis (Gilead), Volibris (GSK)
Central Nervous System Sinusitis (<10%) Indications: Pulmonary arterial hypertension
Cognitive impairment (>10%) Genitourinary Class: Antihypertensive, Endothelin receptor
Coma [2] Erectile dysfunction (prolonged erection / (ETR) antagonist, Vasodilator
Depression (>10%) >4 hours) (4%) Half-life: 9 hours
Dysarthria (>10%) Penile pain (>10%) Clinically important, potentially hazardous
Incoordination (<10%) Priapism (4%) [8] interactions with: conivaptan, cyclosporine,
Memory loss [2] Urethral burning (>10%) [2] CYP2C19 inhibitors and inducers, CYP3A4
Neurotoxicity [2] inhibitors and inducers, dasatinib, deferasirox,
Paresthesias (2%) Local
Application-site burning [3] grapefruit juice, St John’s wort
Restlessness [2] Pregnancy category: X
Sedation [2] Application-site erythema [3]
Seizures (<10%) [2] Application-site pain [2]
Somnolence (drowsiness) (>10%) Application-site pruritus [2]
Injection-site ecchymoses (<10%) pediatric patients
Neuromuscular/Skeletal Injection-site hematoma (3%) Note: Also contra-indicated in patients with
Asthenia (fatigue) (>10%) [2] Injection-site pain (2%) idiopathic pulmonary fibrosis.
Endocrine/Metabolic Warning: CONTRA-INDICATED IN
Galactorrhea [2] PREGNANCY
Genitourinary ALTEPLASE Skin

Micturition difficulty (>10%)
Synonym: tPA Edema [3]
Trade name: Activase (Genentech) Peripheral edema (17%) [8]
ALPROSTADIL Indications: Acute myocardial infarction, acute Mucosal

pulmonary embolism Nasal congestion (6%) [2]
Synonyms: PGE; prostaglandin E1 Class: Fibrinolytic, Plasminogen activator Cardiovascular
Trade names: Caverject (Pfizer), Edex Half-life: 3045 minutes Flushing (4%)
(Schwarz), Muse (Vivus), Prostin VR (Pfizer) Clinically important, potentially hazardous Palpitation (5%)
Indications: Impotence, to maintain patent interactions with: defibrotide, nitroglycerin,
ticlopidine Central Nervous System
ductus arteriosus Headache (15%) [3]
Class: Prostaglandin Pregnancy category: C
Half-life: 510 minutes Important contra-indications noted in the Gastrointestinal/Hepatic
Clinically important, potentially hazardous prescribing guidelines for: the elderly; nursing Abdominal pain (3%)
interactions with: acebutolol, alfuzosin, mothers Constipation (4%)
captopril, cilazapril, enalapril, fosinopril, Hepatotoxicity [3]
irbesartan, lisinopril, olmesartan, quinapril, Skin Respiratory
ramipril Anaphylactoid reactions/Anaphylaxis [5] Dyspnea (4%)
Pregnancy category: D (not indicated for use in Angioedema [12] Nasopharyngitis (3%)
women) Ecchymoses (<10%) Sinusitis (3%)
Important contra-indications noted in the Purpura (<10%) Hematologic
prescribing guidelines for: pediatric patients Central Nervous System Anemia [4]
Warning: APNEA (in neonates with congenital Fever (<10%)
heart defects) Intracranial hemorrhage [8]
Skin
Gastrointestinal/Hepatic AMCINONIDE
Hemorrhagic colitis (5%)
Edema (<10%) See: www.drugeruptiondata.com/drug/id/1096
Penile rash (<10%) Hematologic
Bleeding [2]
Mucosal Hemorrhage (4%)
Nasal congestion (<10%)
Other AMIFOSTINE
Cardiovascular Death [4]
Bradycardia (<10%) See: www.drugeruptiondata.com/drug/id/24
Flushing (>10%)
Hypertension (<10%)
Hypotension (<10%) ALTRETAMINE
Tachycardia (<10%)
Litt’s Drug Eruption & Reaction Manual AMINOSALICYLATE SODIUM
Respiratory
AMIKACIN Cough (<10%) AMINOPHYLLINE
Dyspnea (<10%)
Trade name: Amikacin sulfate (Bedford) Synonym: theophylline ethylenediamine
Indications: Short-term treatment of serious Endocrine/Metabolic Trade names: Elixophyllin (Forest), Phyllocontin
infections due to gram-negative bacteria Gynecomastia (<10%) (Napp), Quibron (Monarch)
Class: Antibiotic, aminoglycoside Hyperkalemia [2] Indications: Prevention or treatment of
Half-life: 1.52.5 hours (adults) Genitourinary reversible bronchospasm
Clinically important, potentially hazardous Impotence (<10%) Class: Xanthine alkaloid
interactions with: adefovir, aldesleukin, Half-life: 315 hours (in adult nonsmokers)
aminoglycosides, atracurium, bumetanide, Clinically important, potentially hazardous
cephalexin, doxacurium, ethacrynic acid,
furosemide, succinylcholine, teicoplanin,
AMINOCAPROIC ACID interactions with: adenosine, anagrelide,
arformoterol, azithromycin, BCG vaccine,
torsemide See: www.drugeruptiondata.com/drug/id/27 caffeine, capsicum, carbimazole, cimetidine,
Pregnancy category: D ciprofloxacin, clorazepate, cocoa, erythromycin,
Important contra-indications noted in the eucalyptus, febuxostat, fluvoxamine, halothane,
prescribing guidelines for: nursing mothers; indacaterol, influenza vaccine, levofloxacin,
pediatric patients AMINO- mebendazole, methylprednisolone, moxifloxacin,
Note: Aminoglycosides may cause neurotoxicity nilutamide, norfloxacin, obeticholic acid,
and/or nephrotoxicity.
GLUTETHIMIDE ofloxacin, oral contraceptives, prednisolone,
prednisone, propranolol, rasagiline, raspberry
Skin leaf, roflumilast, ropivacaine, roxithromycin, St
Dermatitis [2] John’s wort, torasemide, torsemide,
Exanthems [2] triamcinolone, zafirlukast
AMINOLEVULINIC Pregnancy category: C
Central Nervous System Important contra-indications noted in the
Neurotoxicity (<10%) ACID prescribing guidelines for: the elderly; nursing
Renal mothers
Trade names: Ameluz (Biofrontera), Levulan
Nephrotoxicity (<10%) [11]
Kerastick (Dusa)
Otic Indications: Non-hyperkeratotic actinic Skin
Hearing loss [5] keratoses of face and scalp Dermatitis [7]
Ototoxicity (<10%) [8] Class: Photosensitizer, Protoporphyrin IX (PpIX) Exanthems [5]
Tinnitus [3] (wakefulness promoting agent) Exfoliative dermatitis [6]
Ocular Half-life: 20–40 hours Hypersensitivity [6]
Macular infarction [3] Clinically important, potentially hazardous Pruritus [3]
interactions with: none known Stevens-Johnson syndrome [3]
Pregnancy category: C Urticaria [6]
Important contra-indications noted in the Cardiovascular
AMILORIDE prescribing guidelines for: nursing mothers; Arrhythmias [2]
pediatric patients Palpitation [3]
Trade names: Midamor (Merck), Moduretic
Note: In photodynamic therapy: to be used in Tachycardia [2]
(Merck)
conjunction with the relevant illuminator as
Indications: Prevention of hypokalemia Central Nervous System
approved by the manufacturer.
associated with kaliuretic diuretics, management Insomnia [2]
of edema in hypertension Seizures [11]
Class: Diuretic, potassium-sparing Skin Tremor [2]
Half-life: 69 hours Burning (>50%) [6] Neuromuscular/Skeletal
Clinically important, potentially hazardous Crusting (6471%) [2] Rhabdomyolysis [5]
interactions with: ACE inhibitors, benazepril, Dermatitis [2]
captopril, cyclosporine, enalapril, fosinopril, Desquamation [2] Gastrointestinal/Hepatic
lisinopril, magnesium, metformin, moexipril, Edema (35%) [9] Abdominal pain [2]
potassium salts, quinapril, quinidine, ramipril, Erosions (14%) [2] Nausea [5]
spironolactone, trandolapril, zofenopril Erythema (99%) [13] Vomiting [2]
Pregnancy category: B Exfoliative dermatitis (from topical Endocrine/Metabolic
Note: Moduretic is amiloride and treatment) [3] SIADH [2]
hydrochlorothiazide. Hydrochlorothiazide is a Hypomelanosis (22%)
Other
sulfonamide and can be absorbed systemically. Photosensitivity [3]
Adverse effects [3]
Sulfonamides can produce severe, possibly fatal, Pigmentation (from topical treatment) (22%)
Allergic reactions [5]
reactions such as toxic epidermal necrolysis and [7]
Death [2]
Stevens-Johnson syndrome. Pruritus (25%) [2]
Pustules (<4%)
Scaling (6471%)
Skin AMINOSALICYLATE
Stinging (>50%) [2]
Photosensitivity [4]
Ulcerations (4%)
Central Nervous System Vesiculation (4%) [2] SODIUM
Headache (<10%)
Central Nervous System See: www.drugeruptiondata.com/drug/id/30
Vertigo (dizziness) (<10%)
Dysesthesia (2%)
Neuromuscular/Skeletal Pain [12]
Asthenia (fatigue) (<10%)
Myalgia/Myopathy (<10%)
AMIODARONE See all our books at www.crcpress.com
Hair Other
AMIODARONE Alopecia [5] Adverse effects [5]
Mucosal Death [8]
Trade names: Cordarone (Wyeth), Pacerone Side effects (12%) [4]
(Upsher-Smith) Sialorrhea (<10%)
Indications: Ventricular fibrillation, ventricular Cardiovascular
tachycardia Arrhythmias (<3%) [3]
Class: Antiarrhythmic, Antiarrhythmic class III, Atrial fibrillation (paroxysmal) [3] AMISULPRIDE
CYP1A2 inhibitor, CYP3A4 inhibitor Atrioventricular block [3]
Half-life: 26107 days Bradycardia [18] See: www.drugeruptiondata.com/drug/id/1281
Clinically important, potentially hazardous Cardiotoxicity [3]
interactions with: abarelix, acebutolol, Flushing (<10%)
acenocoumarol, afatinib, amisulpride, Hypotension (16%) [4] AMITRIPTYLINE
amitriptyline, amprenavir, anisindione, QT prolongation [24]
anticoagulants, arsenic, artemether/lumefantrine, Tachycardia [2] Trade names: Elavil (AstraZeneca), Limbitrol
asenapine, astemizole, atazanavir, atorvastatin, Thrombophlebitis [2] (Valeant)
azoles, betrixaban, boceprevir, bosentan, Torsades de pointes [35] Indications: Depression
carbimazole, celiprolol, cholestyramine, Ventricular arrhythmia [2] Class: Antidepressant, tricyclic, Muscarinic
cimetidine, ciprofloxacin, clopidogrel, cobicistat/ Central Nervous System antagonist
elvitegravir/emtricitabine/tenofovir alafenamide, Anorexia (10–33%) Half-life: 1025 hours
cobicistat/elvitegravir/emtricitabine/tenofovir Coma [2] Clinically important, potentially hazardous
disoproxil, colchicine, cyclosporine, dabigatran, Dysgeusia (taste perversion) (<10%) interactions with: adrenergic neurone blockers,
daclatasvir, darunavir, degarelix, delavirdine, Headache (3–40%) alcohol, alfuzosin, altretamine, amiodarone,
dextromethorphan, dicumarol, digoxin, diltiazem, Insomnia (3–40%) amphetamines, amprenavir, anticholinergics,
disopyramide, dronedarone, droperidol, Neurotoxicity [5] antiepileptics, antihistamines, antimuscarinics,
echinacea, enoxacin, fentanyl, flecainide, Paresthesias (49%) antipsychotics, apraclonidine, arsenic,
fosamprenavir, gatifloxacin, grapefruit juice, Parkinsonism [4] artemether/lumefantrine, aspirin, atomoxetine,
indinavir, ledipasvir & sofosbuvir, lesinurad, Parosmia (<10%) baclofen, barbiturates, brimonidine, bupropion,
levofloxacin, levomepromazine, lidocaine, Peripheral neuropathy [4] cannabis extract, carbamazepine, cimetidine,
lomefloxacin, lopinavir, loratadine, macrolide Syncope [2] cinacalcet, ciprofloxacin, cisapride, clonidine,
antibiotics, methotrexate, moxifloxacin, Tremor (3–40%) [4] clozapine, cobicistat/elvitegravir/emtricitabine/
naldemedine, nelfinavir, nevirapine, nilotinib, Vertigo (dizziness) (3–40%) tenofovir alafenamide, cobicistat/elvitegravir/
norfloxacin, ofloxacin, orlistat, oxprenolol, emtricitabine/tenofovir disoproxil, conivaptan,
pentamidine, phenytoin, pimavanserin, Neuromuscular/Skeletal coumarins, CYP2D6 inhibitors, desmopressin,
procainamide, propranolol, quinidine, quinine, Ataxia [4] dexmethylphenidate, diltiazem, disopyramide,
quinolones, ribociclib, rifabutin, rifampin, Myoclonus [2] disulfiram, diuretics, dronedarone, droperidol,
rifapentine, ritonavir, ropivacaine, rosuvastatin, Rhabdomyolysis [7] duloxetine, entacapone, ephedra, epinephrine,
simvastatin, sofosbuvir & velpatasvir, sofosbuvir/ Gastrointestinal/Hepatic estrogens, eucalyptus, flecainide, gadobutrol,
velpatasvir/voxilaprevir, sotalol, sparfloxacin, St Abdominal pain (<10%) general anesthetics, gotu kola, grapefruit juice,
John’s wort, sulpiride, tacrolimus, telaprevir, Constipation (10–33%) guanethidine, histamine, interferon alfa,
tetrabenazine, thalidomide, tipranavir, trazodone, Hepatic failure [2] iobenguane, isocarboxazid, isoproterenol, kava,
vandetanib, venetoclax, verapamil, warfarin, Hepatic steatosis [2] linezolid, lithium, MAO inhibitors,
zuclopenthixol Hepatitis (<3%) [3] methylphenidate, metoclopramide,
Pregnancy category: D Hepatotoxicity [27] moclobemide, moxifloxacin, moxonidine,
Important contra-indications noted in the Nausea (10–33%) nefopam, nicorandil, nilotinib, nitrates, NSAIDs,
prescribing guidelines for: the elderly; nursing Pancreatitis [4] opioid analgesics, paroxetine hydrochloride,
mothers; pediatric patients Vomiting (10–33%) pentamidine, phenelzine, phenothiazines,
Warning: PULMONARY TOXICITY phenytoin, pimozide, pramlintide, primidone,
Respiratory
propafenone, propoxyphene, protease inhibitors,
Cough [2]
Skin QT interval prolonging agents, quinidine, quinine,
Eosinophilic pneumonia [2]
Anaphylactoid reactions/Anaphylaxis [2] quinolones, rasagiline, ritonavir, saquinavir,
Pneumonia [4]
Angioedema [2] selegiline, sibutramine, sodium oxybate, sotalol,
Pneumonitis [5]
Diaphoresis [2] sparfloxacin, SSRIs, St John’s wort, sulfonylureas,
Edema (<10%) terbinafine, tetrabenazine, thioridazine, thyroid
Endocrine/Metabolic hormones, tramadol, tranylcypromine, valerian,
Erythema nodosum [2] Hyperthyroidism (<3%) [10]
Exanthems [5] valproic acid, verapamil, vitamin K antagonists,
Hyponatremia [2] yohimbine, ziprasidone
Facial erythema (3%) [2] Hypothyroidism (<3%) [18]
Iododerma [2] Pregnancy category: C
SIADH [10] Important contra-indications noted in the
Linear IgA bullous dermatosis [6] Thyroid dysfunction [25]
Lupus erythematosus [5] prescribing guidelines for: the elderly; nursing
Thyrotoxicosis [19] mothers; pediatric patients
Myxedema [3]
Photosensitivity (10–75%) [41] Genitourinary Note: Limbitrol is amitriptyline and
Phototoxicity [3] Epididymitis [2] chlordiazepoxide.
Pigmentation (blue) (<10%) [68] Warning: SUICIDALITY AND
Ocular
Pruritus (<5%) [2] ANTIDEPRESSANT DRUGS
Corneal deposits (>90%) [2]
Psoriasis [2] Keratopathy [6]
Purpura (2%) Ocular adverse effects [4] Skin
Toxic epidermal necrolysis [2] Ocular toxicity [2] Diaphoresis (<10%)
Toxicity [5] Optic neuropathy [7] DRESS syndrome [2]
Vasculitis [6] Visual disturbances (2–9%) Photosensitivity [3]
Pigmentation [4]
Litt’s Drug Eruption & Reaction Manual AMOXAPINE
Pruritus [3] Pregnancy category: C Pregnancy category: N/A

Pseudolymphoma [2] Important contra-indications noted in the Important contra-indications noted in the
Purpura [2] prescribing guidelines for: the elderly; nursing prescribing guidelines for: pediatric patients
Mucosal mothers; pediatric patients
Xerostomia (>10%) [16] Note: Caduet is amlodipine and atorvastatin; Skin
Exforge is amlodipine and valsartan; Lotrel is Pruritus [3]
Cardiovascular amlodipine and benazepril; Prestalia is amlodipine
Brugada syndrome [4] and perindopril; Tekamlo is amlodipine and Central Nervous System
Myocardial infarction [2] aliskiren. Extrapyramidal symptoms [3]
Postural hypotension [2] Neuromuscular/Skeletal
QT prolongation [2] Asthenia (fatigue) [4]
Skin
Central Nervous System Angioedema [6] Gastrointestinal/Hepatic
Delirium [2] Dermatitis (<10%) Abdominal pain [3]
Depression [2] Edema (514%) [20] Diarrhea [3]
Dysgeusia (taste perversion) (>10%) [2] Erythema multiforme [2] Vomiting [7]
Hallucinations [3] Exanthems (24%) [2]
Headache [2] Hematologic
Peripheral edema (>10%) [44] Neutropenia [2]
Restless legs syndrome [2] Pigmentation [2]
Sedation [3] Pruritus (24%) [3] Other
Seizures [7] Rash (<10%) Adverse effects [2]
Serotonin syndrome [4] Telangiectasia (facial) [5] Death [2]
Somnolence (drowsiness) [6] Toxic epidermal necrolysis [2]
Vertigo (dizziness) [6] Toxicity [2]
Neuromuscular/Skeletal Vasculitis [2] AMOXAPINE
Asthenia (fatigue) [3] Mucosal
Rhabdomyolysis [2] Gingival hyperplasia/hypertrophy [29] Trade name: Amoxapine (Watson)
Gastrointestinal/Hepatic Indications: Depression
Cardiovascular Class: Antidepressant, tricyclic, Muscarinic
Cholestasis [2] Flushing (<10%) [5]
Constipation [4] antagonist
Hypotension [7] Half-life: 1130 hours
Nausea [2]
Central Nervous System Clinically important, potentially hazardous
Endocrine/Metabolic Headache [12] interactions with: amprenavir, artemether/
SIADH [5] Parkinsonism [2] lumefantrine, clonidine, dronedarone,
Weight gain [7] Syncope [2] epinephrine, fluoxetine, guanethidine,
Otic Vertigo (dizziness) [13] iobenguane, isocarboxazid, linezolid, MAO
Tinnitus [3] Neuromuscular/Skeletal inhibitors, nilotinib, phenelzine, pimozide,
Ocular Asthenia (fatigue) [5] quetiapine, quinine, quinolones, sparfloxacin,
Hallucinations, visual [2] Rhabdomyolysis [2] tetrabenazine, thioridazine, toremifene,
Vision blurred [2] tranylcypromine, vandetanib, vemurafenib,
Gastrointestinal/Hepatic ziprasidone
Other Diarrhea [3] Pregnancy category: C
Adverse effects [5] Gastritis [2] Important contra-indications noted in the
Death [3] Hepatotoxicity [3] prescribing guidelines for: the elderly; nursing
Nausea [5] mothers; pediatric patients
Vomiting [2] Warning: SUICIDALITY AND
AMLEXANOX Respiratory ANTIDEPRESSANT DRUGS
Bronchitis [2]
See: www.drugeruptiondata.com/drug/id/1200 Cough [2] Skin
Upper respiratory tract infection [4] AGEP [3]
Other Diaphoresis (<10%)
AMLODIPINE Adverse effects [8] Edema (<10%)
Exanthems [2]
Trade names: Caduet (Pfizer), Exforge Rash (<10%)
(Novartis), Istin (Pfizer), Lotrel (Novartis), AMOBARBITAL Toxic epidermal necrolysis [2]
Norvasc (Pfizer), Prestalia (Symplmed), Tekamlo Mucosal
(Novartis) See: www.drugeruptiondata.com/drug/id/34 Xerostomia (14%)
Indications: Hypertension, angina
Class: Antiarrhythmic class IV, Calcium channel Central Nervous System
blocker Dysgeusia (taste perversion) (>10%)
Half-life: 3050 hours AMODIAQUINE Headache (<10%)
Clinically important, potentially hazardous Insomnia (<10%)
interactions with: amprenavir, carbamazepine, Trade names: Camoquin (Pfizer), Flavoquin Neuroleptic malignant syndrome [2]
cobicistat/elvitegravir/emtricitabine/tenofovir (Sanofi-Aventis) Somnolence (drowsiness) (14%)
alafenamide, cobicistat/elvitegravir/emtricitabine/ Indications: Malaria Vertigo (dizziness) (<10%)
tenofovir disoproxil, conivaptan, delavirdine, Class: Anti-inflammatory, Antimalarial Neuromuscular/Skeletal
epirubicin, imatinib, phenytoin, primidone, Half-life: 15.7–19.5 hours Asthenia (fatigue) (<10%)
sildenafil, simvastatin, St John’s wort, tadalafil, Clinically important, potentially hazardous
interactions with: none known Gastrointestinal/Hepatic
telaprevir Constipation (12%)
Nausea (<10%)
AMOXAPINE Over 100 updates per week on www.drugeruptiondata.com
Endocrine/Metabolic Hepatotoxicity [36] Neuromuscular/Skeletal

Galactorrhea [2] Nausea [13] Asthenia (fatigue) (13%)
Ocular Vomiting [9] Back pain (12%)
Vision blurred (7%) Genitourinary Gastrointestinal/Hepatic
Other Vaginitis [3] Abdominal pain (20%)
Side effects (5%) Renal Diarrhea (30%)
Nephrotoxicity [2] Gastrointestinal bleeding (10%)
Hepatotoxicity [5]
Other Nausea (40%)
AMOXICILLIN Adverse effects [20] Vomiting (32%)
Kounis syndrome [6]
Synonym: amoxycillin Side effects [4] Respiratory
Trade names: Amoxil (GSK), Augmentin (GSK), Tooth fluorosis [2] Bronchospasm [2]
Prevpac (TAP), Trimox (Bristol-Myers Squibb) Cough (18%)
Indications: Infections of the respiratory tract, Dyspnea (23%)
Hypoxia (8%)
skin and urinary tract
Class: Antibiotic, penicillin
AMPHOTERICIN B Pleural effusion (13%)
Half-life: 0.71.4 hours Pulmonary toxicity (18%)
Trade names: Abelcet (Sigma-Tau), AmBisome Rhinitis (11%)
Clinically important, potentially hazardous (Astellas), Amphocin (Pfizer), Amphotec
interactions with: allopurinol, bromelain, Tachypnea (>10%)
(Alkopharma)
chloramphenicol, demeclocycline, doxycycline, Indications: Potentially life-threatening fungal Endocrine/Metabolic
erythromycin, imipenem/cilastatin, methotrexate, infections ALP increased (22%)
minocycline, omeprazole, oxytetracycline, Class: Antifungal ALT increased (15%)
sulfonamides, tetracycline Half-life: initial: 1548 hours; terminal: 15 days AST increased (13%)
Pregnancy category: B Clinically important, potentially hazardous Creatine phosphokinase increased (22%)
Note: Augmentin is amoxicillin and clavulanic interactions with: adefovir, aminoglycosides, Hyperglycemia (23%)
acid. arsenic, astemizole, betamethasone, cephalothin, Hypernatremia (4%)
cidofovir, cyclosporine, digoxin, ethoxzolamide, Hypervolemia (12%)
Skin fluconazole, flucytosine, ganciclovir, griseofulvin, Hypocalcemia (18%)
AGEP [28] hydrocortisone, itraconazole, ketoconazole, Hypokalemia [2]
Anaphylactoid reactions/Anaphylaxis [15] micafungin, pentamidine, probenecid, sulpiride, Hypomagnesemia (20%)
Angioedema (<10%) [5] terbinafine, triamcinolone, voriconazole Genitourinary
Baboon syndrome (SDRIFE) [11] Pregnancy category: B Hematuria (14%)
Bullous pemphigoid [2] Important contra-indications noted in the Urinary retention (<10%)
Dermatitis [4] prescribing guidelines for: nursing mothers
Renal
DRESS syndrome [6] Nephrotoxicity [50]
Edema [2] Skin
Erythema multiforme [18] Hematologic
Anaphylactoid reactions/Anaphylaxis [4] Anemia (>10%) [4]
Exanthems (>5%) [33] Diaphoresis (7%)
Fixed eruption [10] Leukocytosis (<10%)
Exanthems [4] Sepsis (14%)
Hypersensitivity [5] Peripheral edema (15%)
Jarisch–Herxheimer reaction [2] Pruritus (11%) [2] Local
Linear IgA bullous dermatosis [3] Purpura [3] Infusion-related reactions [5]
Pemphigus [4] Rash (25%) Injection-site pain (>10%)
Pruritus [7] Toxicity [2] Injection-site reactions [5]
Pustules [8] Urticaria [2] Other
Rash (<10%) [14] Adverse effects [5]
Serum sickness-like reaction (<10%) [6] Mucosal
Epistaxis (nosebleed) (15%) Death [4]
Stevens-Johnson syndrome [11] Infection (11%)
Toxic epidermal necrolysis [13] Cardiovascular
Toxic pustuloderma [2] Chest pain (12%)
Urticaria (<5%) [16] Flushing (<10%) [2]
Mucosal Hypertension (8%) [4] AMPICILLIN
Stomatitis [2] Hypotension (14%)
Tachycardia (13%) Trade name: Totacillin (GSK)
Central Nervous System Thrombophlebitis (<10%) Indications: Susceptible strains of gram-negative
Anorexia [2] and gram-positive bacterial infections
Dysgeusia (taste perversion) [6] Central Nervous System Class: Antibiotic, penicillin
Hallucinations [3] Anorexia (>10%) Half-life: 11.5 hours
Headache [5] Anxiety (14%) Clinically important, potentially hazardous
Somnolence (drowsiness) [3] Chills (48%) [5] interactions with: allopurinol, anticoagulants,
Vertigo (dizziness) [5] Confusion (11%) chloramphenicol, cyclosporine, demeclocycline,
Delirium (>10%) doxycycline, erythromycin, levodopa,
Neuromuscular/Skeletal Fever (>10%) [5]
Asthenia (fatigue) [3] methotrexate, minocycline, oxytetracycline,
Headache (20%) sulfonamides, tetracycline
Rhabdomyolysis [2] Insomnia (17%) Pregnancy category: B
Gastrointestinal/Hepatic Leukoencephalopathy [4] Important contra-indications noted in the
Abdominal distension [2] Pain (14%) prescribing guidelines for: nursing mothers
Abdominal pain [7] Paresthesias (<10%) Note: Five to 10% of people taking ampicillin
Diarrhea [18] Parkinsonism [2] develop eruptions between the 5th and 14th day
Dyspepsia [2] following initiation of therapy. Also, there is a
Litt’s Drug Eruption & Reaction Manual ANDROSTENEDIONE
95% incidence of exanthematous eruptions in Pregnancy category: N/A (Contra-indicated in

patients who are treated for infectious AMPRENAVIR women of premenopausal endocrine status,
mononucleosis with ampicillin. The allergenicity including pregnant women)
of ampicillin appears to be enhanced by See: www.drugeruptiondata.com/drug/id/39 Important contra-indications noted in the
allopurinol or by hyperuricemia. Ampicillin is prescribing guidelines for: nursing mothers
clearly the more allergenic of the two drugs when Note: The efficacy of anastrozole in the
given alone. AMYL NITRITE treatment of pubertal gynecomastia in adolescent
boys and in the treatment of precocious puberty
Skin See: www.drugeruptiondata.com/drug/id/40 in girls with McCune-Albright syndrome has not
AGEP [9] been demonstrated.
Angioedema [2] ANAGRELIDE Skin
Baboon syndrome (SDRIFE) [3] Hot flashes (12–36%) [12]
Dermatitis [8] See: www.drugeruptiondata.com/drug/id/896 Lupus erythematosus [3]
Erythema multiforme [11] Peripheral edema (10%)
Exanthems (>10%) [84] Pruritus (25%)
Exfoliative dermatitis [3] ANAKINRA Rash (6–11%) [2]
Fixed eruption [10] Hair
Hypersensitivity [5] Trade name: Kineret (Amgen) Alopecia (25%)
Linear IgA bullous dermatosis [4] Indications: Rheumatoid arthritis, neonatal-
Pemphigus [6] Cardiovascular
onset multisystem inflammatory disease Angina (2%)
Pruritus (<5%) [5] Class: Disease-modulating antirheumatoid drug,
Psoriasis [5] Flushing (>5%)
Interleukin-1 receptor antagonist (IL-IRa) Hypertension (2–13%)
Purpura [6] Half-life: 46 hours
Pustules [4] Thrombophlebitis (25%)
Rash (<10%) interactions with: abatacept, adalimumab, Central Nervous System
Stevens-Johnson syndrome [10] certolizumab, etanercept, golimumab, infliximab, Carpal tunnel syndrome [2]
Toxic epidermal necrolysis [15] lenalidomide, live vaccines Depression (5–13%)
Urticaria [16] Pregnancy category: B Headache (9–13%) [2]
Vasculitis [4] Important contra-indications noted in the Pain (14%)
Hematologic prescribing guidelines for: nursing mothers Tumor pain (>5%)
Thrombocytopenia [2] Neuromuscular/Skeletal
Local Central Nervous System Arthralgia (25%) [8]
Injection-site pain (>10%) Fever (12%) Asthenia (fatigue) (19%) [7]
Headache (12–14%) [2] Back pain (12%) [2]
Other Bone or joint pain (6–11%) [2]
Allergic reactions (<10%) [3] Neuromuscular/Skeletal Joint disorder [3]
Arthralgia (6–12%) Myalgia/Myopathy (25%) [2]
Gastrointestinal/Hepatic Osteoporosis (11%)
AMPICILLIN/ Abdominal pain (5%) Gastrointestinal/Hepatic
Diarrhea (8%) Diarrhea [2]
SULBACTAM Nausea (8%) Hepatitis [2]
Vomiting (14%) Hepatotoxicity [5]
Trade name: Unasyn (Pfizer)
Indications: Various infections caused by Respiratory Nausea (11–19%)
susceptible organisms Flu-like syndrome (6%) Vomiting (8–13%)
Class: Antibiotic, beta-lactam, Antibiotic, Nasopharyngitis (12%) Respiratory
penicillin Sinusitis (7%) Cough (11%)
Half-life: 1 hour Upper respiratory tract infection (4%) [2] Flu-like syndrome (7%)
Clinically important, potentially hazardous Local Pharyngitis (6–14%)
interactions with: allopurinol, probenecid Injection-site edema [2] Endocrine/Metabolic
Pregnancy category: B Injection-site erythema [3] Mastodynia (25%)
Important contra-indications noted in the Injection-site inflammation [2]
prescribing guidelines for: nursing mothers Injection-site pain [4] Genitourinary
Note: Serious and occasionally fatal Injection-site reactions (71%) [31] Vaginal dryness (2%) [2]
hypersensitivity (anaphylactic) reactions have Other Other
been reported in patients on penicillin therapy. Adverse effects [5] Infection (25%)
Contra-indicated in patients with a history of Infection (40%) [11]
hypersensitivity reactions to any of the penicillins.
ANDROSTENEDIONE
Skin ANASTROZOLE
Anaphylactoid reactions/Anaphylaxis [2] See: www.drugeruptiondata.com/drug/id/801
Linear IgA bullous dermatosis [3] Trade name: Arimidex (AstraZeneca)
Rash (<10%) Indications: Breast carcinoma (localized –
Gastrointestinal/Hepatic advanced or metastatic)
Diarrhea (<10%) Class: Antineoplastic, Aromatase inhibitor
Local Half-life: 50 hours
Injection-site pain (16%) Clinically important, potentially hazardous
interactions with: estradiol, estrogens,
tamoxifen
ANIDULAFUNGIN See all our books at www.crcpress.com
Hypoglycemia (7%) Central Nervous System

ANIDULAFUNGIN Hypokalemia (5–15%) Chills [2]
Hypomagnesemia (12%) Fever [3]
Trade names: Ecalta (Pfizer), Eraxis (Pfizer) Guillain–Barré syndrome [2]
Indications: Candidemia, candidal esophagitis Genitourinary
Urinary tract infection (15%) Headache (4–64%) [2]
Class: Antimycobacterial, echinocandin
Half-life: 4050 hours Hematologic Neuromuscular/Skeletal
Clinically important, potentially hazardous Anemia (8–9%) Arthralgia [3]
interactions with: none known Coagulopathy (<2%) Asthenia (fatigue) (5–62%)
Pregnancy category: C Leukocytosis (5%) Myalgia/Myopathy (2–72%) [3]
Important contra-indications noted in the Sepsis (7%) Gastrointestinal/Hepatic
prescribing guidelines for: nursing mothers; Thrombocythemia (6%) Diarrhea (6–8%)
pediatric patients Thrombocytopenia (<2%) Nausea (6%)
Ocular Respiratory
Skin Ocular pain (<2%) Flu-like syndrome [3]
Angioedema (<2%) Vision blurred (<2%) Nasopharyngitis (12–15%)
Erythema (<2%) Visual disturbances (<2%) Genitourinary
Hot flashes (<2%) Local Dysmenorrhea (7%)
Hyperhidrosis (<2%) Infusion-related reactions [2]
Peripheral edema (11%) Local
Pruritus (<2%) Other Injection-site edema [4]
Ulcerations (5%) Adverse effects [3] Injection-site nodules [2]
Urticaria (<2%) Infection (63%) Injection-site pain [4]
Injection-site pruritus [2]
Mucosal Injection-site reactions [6]
Oral candidiasis (5%)
Cardiovascular
ANISINDIONE Other
Atrial fibrillation (<2%) See: www.drugeruptiondata.com/drug/id/898
Bundle branch block (<2%)
Chest pain (5%)
Flushing (<2%) [2] ANTI-THYMOCYTE
Hypertension (12%) ANISTREPLASE
Hypotension (15%) GLOBULIN (EQUINE)
Phlebitis [2] See: www.drugeruptiondata.com/drug/id/41
Thrombophlebitis (<2%)
Venous thromboembolism (10%)
Central Nervous System ANTHRAX VACCINE
Confusion (8%)
ANTI-THYMOCYTE
Trade name: BioThrax (Emergent BioSolutions)
Depression (6%)
Fever (9–18%) [3] Indications: Anthrax prophylaxis IMMUNOGLOBULIN
Class: Vaccine
Headache (8%) [5]
Half-life: Requires 1 month to achieve immunity
(RABBIT)
Insomnia (15%)
Rigors (<2%) (92.5% efficient)
Seizures (<2%) Clinically important, potentially hazardous
Vertigo (dizziness) (<2%) interactions with: corticosteroids,
immunosuppressive therapies, other vaccines
Neuromuscular/Skeletal Pregnancy category: D ANTIHEMOPHILIC
Back pain (5%) Important contra-indications noted in the
Gastrointestinal/Hepatic prescribing guidelines for: the elderly; nursing FACTOR
Abdominal pain (6%) mothers; pediatric patients
Synonym: rFV111Fc
Cholestasis (<2%) Note: Dr. Sue Bailey, Assistant Secretary for
Trade names: Afstyla (CSL Behring), Eloctate
Constipation (8%) Health Affairs, released a statement on June 29,
(Biogen Idec), Kovaltry (Bayer)
Diarrhea (9–18%) 1999 that ‘almost one million shots given, the
Indications: Control and prevention of bleeding
Dyspepsia (aggravated) (7%) anthrax immunization is proving to be one of the
episodes in Hemophilia A
Hepatotoxicity [4] safest vaccination programs on record.’ The
Class: Antihemorrhagic, Recombinant fusion
Nausea (7–24%) [4] ADRs reported occurred for ‘50 service
protein
Vomiting (7–18%) [4] members at one installation alone.’ Note that no
Half-life: 20 hours (adults)
Respiratory number of military personnel was mentioned at
this installation, nor did it give any percentages for
Cough (7%) interactions with: none known
the reactions reported.
Dyspnea (12%)
Pleural effusion (10%)
Pneumonia (6%) Skin
Respiratory distress (6%) Diaphoresis [2]
Endocrine/Metabolic Edema (3%) [2]
ALP increased (12%) Hypersensitivity [5]
ALT increased (2%) Lupus erythematosus [2]
Creatine phosphokinase increased (5%) Pruritus (<10%) [2]
Dehydration (6%) Rash [2]
Hyperglycemia (6%) Stevens-Johnson syndrome [2]
Hyperkalemia (6%) Urticaria [2]
Litt’s Drug Eruption & Reaction Manual APREPITANT
Pregnancy category: C Other telithromycin, terfenadine, tolbutamide,

Important contra-indications noted in the Allergic reactions [5] tolvaptan, trabectedin, triamcinolone,
prescribing guidelines for: nursing mothers troleandomycin, vinblastine, vincristine,
voriconazole, warfarin
Pregnancy category: N/A (Insufficient evidence
APREMILAST
APIXABAN to inform drug-associated risk)
Trade name: Otezla (Celgene)
Trade name: Eliquis (Bristol-Myers Squibb) Indications: Psoriatic arthritis, plaque psoriasis prescribing guidelines for: nursing mothers;
Indications: Reduce the risk of stroke and Class: Phosphodiesterase inhibitor, pediatric patients
systemic embolism in patients with nonvalvular Phosphodiesterase type 4 (PDE4) inhibitor Note: Fosaprepitant is a prodrug of aprepitant
atrial fibrillation Half-life: 6–9 hours for injection. Aprepitant treatment is given along
Class: Anticoagulant, Direct factor Xa inhibitor Clinically important, potentially hazardous with a 5-HT3-receptor antagonist and
Half-life: 5–12 hours interactions with: carbamazepine, dexamethasone.
Clinically important, potentially hazardous phenobarbital, phenytoin, rifampin
interactions with: carbamazepine, darunavir, Pregnancy category: C Skin
phenytoin, rifampin, St John’s wort, tipranavir, Important contra-indications noted in the Pruritus (8%)
voriconazole prescribing guidelines for: nursing mothers; Hair
Pregnancy category: B pediatric patients Alopecia (12%)
prescribing guidelines for: nursing mothers; Mucosal
Central Nervous System Mucocutaneous reactions (3%)
pediatric patients Depression [3]
Note: Contra-indicated in patients with active Stomatitis (3%)
pathological bleeding. Cardiovascular
Warning: DISCONTINUING ELIQUIS IN Neuromuscular/Skeletal Hypertension (2%)
PATIENTS WITHOUT ADEQUATE Arthralgia [2] Hypotension (6%)
CONTINUOUS ANTICOAGULATION Asthenia (fatigue) [5]
INCREASES RISK OF STROKE Gastrointestinal/Hepatic Anorexia (6–10%) [2]
Abdominal pain (<2%) [3] Encephalopathy [2]
Gastrointestinal/Hepatic Diarrhea (8–9%) [28] Fever (3–6%)
Hepatotoxicity [2] Dyspepsia [2] Headache (5–9%) [5]
Nausea (7–9%) [29] Insomnia (2–3%)
Hematologic Vomiting (<3%) [8]
Hemorrhage [15] Somnolence (drowsiness) [2]
Respiratory Vertigo (dizziness) (3–7%) [2]
Other Nasopharyngitis (<3%) [17]
Adverse effects [4] Neuromuscular/Skeletal
Upper respiratory tract infection (<4%) Asthenia (fatigue) (5–18%) [8]
[14]
Endocrine/Metabolic
APOMORPHINE ALT increased [2]
Abdominal pain (5%) [3]
Constipation (9–10%) [8]
Weight loss (10–12%) [5] Diarrhea (<10%) [2]
Other Dyspepsia (5–6%)
Adverse effects [4] Flatulence (4%)
Infection [2] Gastritis (4%)
APRACLONIDINE Nausea (6–13%)
Vomiting (3–8%)
Trade name: Iopidine (Alcon)
Indications: Post-surgical intraocular pressure APREPITANT Endocrine/Metabolic
elevation ALT increased (6%)
Class: Adrenergic alpha2-receptor agonist Trade name: Emend (Merck) AST increased (3%)
Half-life: 8 hours Indications: Prevention of postoperative and Creatine phosphokinase increased (4%)
Clinically important, potentially hazardous chemotherapy induced nausea and vomiting Dehydration (6%)
interactions with: amitriptyline Class: Antiemetic, CYP3A4 inhibitor, Neurokinin Genitourinary
Pregnancy category: C 1 receptor antagonist Urinary tract infection (2%)
Important contra-indications noted in the Half-life: 913 hours
Clinically important, potentially hazardous Renal
interactions with: alprazolam, antifungal agents, Proteinuria (7%)
pediatric patients
astemizole, avanafil, betamethasone, Hematologic
carbamazepine, cisapride, clarithromycin, Anemia (3%)
Skin colchicine, conivaptan, corticosteroids, CYP2C9 Febrile neutropenia [2]
Dermatitis [3] substrates, CYP3A4 inhibitors or inducers, Neutropenia (3–6%) [2]
Pruritus (10%) dasatinib, deferasirox, dexamethasone, diltiazem, Otic
Mucosal docetaxel, eplerenone, estrogens, everolimus, Tinnitus (4%)
Xerostomia (<10%) fentanyl, grapefruit juice, halofantrine, ifosfamide,
imatinib, irinotecan, itraconazole, ketoconazole, Local
Central Nervous System Infusion-site pain [2]
Dysgeusia (taste perversion) (3%) methylprednisolone, midazolam, mifepristone,
naldemedine, nefazodone, neratinib, olaparib, Other
Ocular oral contraceptives, paroxetine hydrochloride, Hiccups (11%) [8]
Conjunctivitis (<5%) phenobarbital, phenytoin, pimecrolimus, Infection [3]
Eyelid edema (<3%) pimozide, progestins, ranolazine, rifampin,
Ocular pruritus (5–15%) rifamycin derivatives, rifapentine, ritonavir,
Xerophthalmia (<5%) salmeterol, saxagliptin, St John’s wort,
APROBARBITAL Over 100 updates per week on www.drugeruptiondata.com
Neuromuscular/Skeletal Central Nervous System

APROBARBITAL Arthralgia (<2%) Agitation (19%) [4]
Back pain (6%) Akathisia (8–13%) [31]
See: www.drugeruptiondata.com/drug/id/44 Leg cramps (4%) Anxiety (17%) [11]
Neck rigidity (<2%) Compulsions [2]
Gastrointestinal/Hepatic Dyskinesia [3]
APROTININ Nausea [2] Extrapyramidal symptoms [9]
Fever (2%)
See: www.drugeruptiondata.com/drug/id/45 Respiratory Headache (27%) [12]
Bronchitis [3] Hypersexuality [2]
COPD (exacerbation) [3] Impulse control disorder [4]
Dysphonia (<2%)
ARBUTAMINE Dyspnea (4%)
Insomnia (18%) [16]
Irritability [4]
Flu-like syndrome (3%) Mania [2]
See: www.drugeruptiondata.com/drug/id/873 Nasopharyngitis [3] Neuroleptic malignant syndrome [14]
Sinusitis (4%) [2] Neurotoxicity [2]
Genitourinary Parkinsonism [11]
ARFORMOTEROL Cystitis (<2%) Psychosis [2]
Nocturia (<2%) Restlessness [8]
Trade name: Brovana (Sunovion) Schizophrenia (exacerbation) [2]
Indications: Chronic obstructive pulmonary Ocular
Glaucoma (<2%) Sedation [10]
disease including chronic bronchitis and Somnolence (drowsiness) (5–11%) [11]
emphysema Visual disturbances (<2%)
Stroke [2]
Class: Beta-2 adrenergic agonist, Bronchodilator Local Suicidal ideation [6]
Half-life: 26 hours Injection-site pain (<2%) Tardive dyskinesia [8]
Clinically important, potentially hazardous Tic disorder [2]
Other
interactions with: aminophylline, beta blockers, Tremor (3%) [9]
Adverse effects [2]
MAO inhibitors, tricyclic antidepressants Vertigo (dizziness) [5]
Allergic reactions (<2%)
Important contra-indications noted in the Neuromuscular/Skeletal
prescribing guidelines for: nursing mothers; Asthenia (fatigue) [5]
pediatric patients ARGATROBAN Ataxia [4]
Note: Studies in asthma patients showed that Dystonia [13]
long-acting beta2-adrenergic agonists may See: www.drugeruptiondata.com/drug/id/811 Pisa syndrome [2]
increase the risk of asthma-related death. Gastrointestinal/Hepatic
Contra-indicated in patients with asthma without Constipation (11%) [3]
use of a long-term asthma control medication. ARIPIPRAZOLE Dyspepsia (9%)
Warning: ASTHMA-RELATED DEATH Nausea (15%) [10]
Trade names: Abilify (Bristol-Myers Squibb), Vomiting (11%) [5]
Skin Aristada (Alkermes) Respiratory
Abscess (<2%) Indications: Schizophrenia, bipolar I disorder, Cough (3%)
Edema (<2%) major depressive disorder, irritability associated Upper respiratory tract infection [3]
Herpes simplex (<2%) with autistic disorder
Class: Antipsychotic, Mood stabilizer Endocrine/Metabolic
Herpes zoster (<2%) Appetite increased [5]
Neoplasms (<2%) Half-life: 7594 hours
Clinically important, potentially hazardous Diabetes mellitus [2]
Peripheral edema (3%) Galactorrhea [2]
Pigmentation (<2%) interactions with: alcohol, atazanavir,
carbamazepine, CYP3A4 inhibitors, efavirenz, Hyperprolactinemia [2]
Rash (4%) SIADH [2]
Xerosis (<2%) itraconazole, ketoconazole, lopinavir, nelfinavir,
paroxetine hydrochloride, quinidine Weight gain (2–30%) [26]
Mucosal Pregnancy category: C Genitourinary
Oral candidiasis (<2%) Important contra-indications noted in the Priapism [3]
Cardiovascular prescribing guidelines for: the elderly; pediatric Vaginitis [2]
Arteriosclerosis (<2%) patients Hematologic
Atrioventricular block (<2%) Warning: INCREASED MORTALITY IN Neutropenia [2]
Chest pain (7%) [2] ELDERLY PATIENTS WITH DEMENTIA-
Digitalis intoxication (<2%) RELATED PSYCHOSIS Ocular
QT prolongation (<2%) SUICIDALITY AND ANTIDEPRESSANT DRUGS
Vision blurred (3–8%)
Supraventricular tachycardia (<2%) Local
Central Nervous System Injection-site pain [5]
Skin
Agitation (<2%) Rash (6%) [2] Other
Fever (<2%) Adverse effects [4]
Headache [2]
Mucosal
Death [3]
Hypokinesia (<2%) Sialorrhea (4–9%) [5]
Hiccups [3]
Insomnia [2] Xerostomia (5%) [7]
Toothache [2]
Nervousness [3] Cardiovascular
Pain (8%) Arrhythmias [2]
Paresthesias (<2%) Hypertension [3]
Somnolence (drowsiness) (<2%) QT prolongation [2]
Tremor (<2%) [3]
Litt’s Drug Eruption & Reaction Manual ASCORBIC ACID
Skin Hearing impairment [2]

ARMODAFINIL Abscess (<3%) Tinnitus (<3%)
Impetigo (<3%) Ocular
Trade name: Nuvigil (Cephalon) Inflammation [3]
Indications: Narcolepsy, obstructive sleep Conjunctivitis (<3%)
Pruritus (4%) [2] Nystagmus (<3%)
apnea, shift work sleep disorder Rash (3%) [6]
Class: Eugeroic Urticaria (<3%) [2] Other
Half-life: 12–15 hours Adverse effects [3]
Clinically important, potentially hazardous Cardiovascular Infection (<3%)
interactions with: cyclosporine Palpitation (18%) [2]
Pregnancy category: C Central Nervous System
prescribing guidelines for: the elderly; nursing
Agitation (<3%)
Anorexia (40%) [6]
ARTESUNATE
mothers; pediatric patients Chills (23%) Trade name: Rtsun (Wiscon)
Fever (25–29%) [6] Indications: Plasmodium falciparum malaria
Central Nervous System Gait instability (<3%) Class: Antimalarial
Anxiety [2] Headache (56%) [8] Half-life: 0.5 hours
Headache (14–23%) [10] Hypoesthesia (<3%) Clinically important, potentially hazardous
Insomnia (4–6%) [3] Insomnia (5%) [2] interactions with: efavirenz
Vertigo (dizziness) (5%) [2] Mood changes (<3%) Pregnancy category: N/A (Use carefully in first
Seizures [2] three trimesters of pregnancy)
Gastrointestinal/Hepatic Sleep disturbances (22%)
Diarrhea [3] Note: Artesunate therapy should be combined
Sleep related disorder [2] with other antimalarials (e.g. mefloquine) if given
Nausea [2] Tremor (<3%) for less than 5 days.
Other Vertigo (dizziness) (39%) [8]
Adverse effects [2] Neuromuscular/Skeletal Skin
Arthralgia (34%) Pruritus [3]
Asthenia (fatigue) (38%) [8]
ARSENIC Ataxia (<3%) Cardiovascular
Back pain (<3%) QT prolongation [2]
See: www.drugeruptiondata.com/drug/id/46 Myalgia/Myopathy (32%) Central Nervous System
Gastrointestinal/Hepatic Anorexia [3]
Abdominal pain (17%) [11] Extrapyramidal symptoms [3]
ARTEMETHER/ Constipation (<3%) Fever [2]
Diarrhea (8%) [11] Headache [8]
LUMEFANTRINE Dyspepsia (<3%) Insomnia [2]
Dysphagia (<3%) Vertigo (dizziness) [12]
Trade name: Coartem (Novartis) Gastroenteritis (<3%) Neuromuscular/Skeletal
Indications: Acute, uncomplicated malaria Hepatomegaly (6–9%) Asthenia (fatigue) [5]
infections due to Plasmodium falciparum in Nausea [8] Myalgia/Myopathy [2]
patients of 5kg bodyweight and above Peptic ulceration (<3%)
Class: Antimalarial
Vomiting [16] Abdominal pain [4]
Half-life: ~2 hours (artemether); 3–6 days
(lumefantrine)
Respiratory Diarrhea [5]
Asthma (<3%) Nausea [6]
Bronchitis (<3%) Vomiting [13]
interactions with: amiodarone, amitriptyline,
amoxapine, antimalarials, antiretrovirals, arsenic,
Cough (6–23%) [2] Respiratory
astemizole, atazanavir, atovaquone/proguanil,
Influenza (<3%) Cough [3]
azithromycin, carbamazepine, ciprofloxacin,
Nasopharyngitis (4%)
Pharyngolaryngeal pain (<3%) Hematologic
citalopram, clomipramine, conivaptan, CYP2D6 Anemia [4]
substrates, CYP3A4 inhibitors, substrates or
Pneumonia (<3%)
Rhinitis (4%) Hemolysis [3]
inducers, darunavir, dasatinib, degarelix, Hemolytic anemia [2]
delavirdine, disopyramide, dolasetron, duloxetine,
Upper respiratory tract infection (<3%)
Neutropenia [2]
flecainide, halofantrine, hormonal contraceptives, Endocrine/Metabolic
imipramine, indinavir, itraconazole, lapatinib, ALT increased (<3%) Other
levofloxacin, levomepromazine, lopinavir, AST increased (<3%) Adverse effects [2]
mefloquine, moxifloxacin, nelfinavir, norfloxacin, Hypokalemia (<3%)
ofloxacin, paroxetine hydrochloride, pazopanib, Genitourinary
phenytoin, pimozide, procainamide, quinidine, Hematuria (<3%) ARTICAINE
quinine, rifampin, risperidone, sotalol, St John’s Urinary tract infection (<3%)
wort, telavancin, telithromycin, terfenadine, See: www.drugeruptiondata.com/drug/id/2435
tipranavir, venlafaxine, voriconazole, vorinostat, Renal
ziprasidone, zuclopenthixol Proteinuria (<3%)
Pregnancy category: C Hematologic ASCORBIC ACID
Important contra-indications noted in the Anemia (4–9%) [4]
prescribing guidelines for: nursing mothers; Eosinophilia (<3%) See: www.drugeruptiondata.com/drug/id/47
pediatric patients Neutropenia [2]
Note: Artemether/Lumefantrine tablets should Platelets decreased (<3%)
not be used to treat severe malaria or to prevent Otic
malaria. Ear infection (<3%)
ASENAPINE See all our books at www.crcpress.com
Skin
ASENAPINE ASFOTASE ALFA Anaphylactoid reactions/Anaphylaxis (340%)
[4]
Trade name: Saphris (Merck) Trade name: Strensiq (Alexion) Angioedema [3]
Indications: Schizophrenia, bipolar disorder Indications: Perinatal/infantile-and juvenile-onset Hypersensitivity (640%) [14]
Class: Antipsychotic hypophosphatasia Toxic epidermal necrolysis [2]
Half-life: 24 hours Class: Enzyme replacement Toxicity [2]
Clinically important, potentially hazardous Half-life: 5 days Urticaria (<15%) [5]
interactions with: alcohol, amiodarone, Clinically important, potentially hazardous
chlorpromazine, CYP2D6 substrates and interactions with: none known Mucosal
inhibitors, fluvoxamine, gatifloxacin, moxifloxacin, Pregnancy category: N/A (No available data) Aphthous stomatitis (<10%)
paroxetine hydrochloride, procainamide, QT Important contra-indications noted in the Oral lesions (26%)
prolonging drugs, quinidine, sotalol, thioridazine, prescribing guidelines for: the elderly; nursing Stomatitis (<10%)
ziprasidone mothers Central Nervous System
Pregnancy category: C Chills (>10%)
Important contra-indications noted in the Skin Coma (25%)
prescribing guidelines for: the elderly; nursing Anaphylactoid reactions/Anaphylaxis Depression (>10%)
mothers; pediatric patients (<10%) Encephalopathy [2]
Warning: INCREASED MORTALITY IN Calcification (4%) Fever (>10%)
ELDERLY PATIENTS WITH DEMENTIA- Erythema (<10%) Leukoencephalopathy [3]
RELATED PSYCHOSIS Neurotoxicity [4]
Cardiovascular Seizures (10–60%) [2]
Flushing (<10%) Somnolence (drowsiness) (>10%)
Skin
Peripheral edema (3%) Central Nervous System Stroke [2]
Chills (<10%) Gastrointestinal/Hepatic
Mucosal Fever (<10%)
Oral numbness [4] Abdominal pain (70%)
Headache (<10%) Hepatotoxicity [3]
Salivary hypersecretion (2%) Hypoesthesia (oral) (<10%)
Xerostomia (2–3%) Pancreatitis (15%) [22]
Irritability (<10%) Vomiting (50–60%)
Cardiovascular Pain (<10%)
Hypertension (2–3%) [2] Rigors (<10%) Endocrine/Metabolic
Hyperglycemia [2]
Central Nervous System Gastrointestinal/Hepatic Hyperlipidemia [2]
Akathisia (4–6%) [10] Nausea (<10%) Hypertriglyceridemia [4]
Anxiety (4%) Vomiting (5%)
Depression (2%) [3] Genitourinary
Local Azotemia (66%)
Dysgeusia (taste perversion) (3%) [4] Injection-site bruising (8%)
Extrapyramidal symptoms (6–10%) [11] Injection-site edema (13%) Hematologic
Headache (12%) [3] Injection-site erythema (41%) Sepsis [2]
Hypersomnia [2] Injection-site hemorrhage (<17%) Thrombosis [9]
Hypoesthesia (4–5%) [7] Injection-site induration (13%) Other
Insomnia (6–15%) [3] Injection-site lipoatrophy/lipohypertrophy Adverse effects [2]
Irritability (2%) (5–8%) Allergic reactions (15–35%) [2]
Sedation [9] Injection-site pain (14%)
Somnolence (drowsiness) (13–24%) [15] Injection-site papules and nodules (3%)
Tardive dyskinesia [2] Injection-site pigmentation (15%)
Vertigo (dizziness) (4–11%) [5] Injection-site pruritus (13%)
ASPARAGINASE
Neuromuscular/Skeletal Injection-site reactions (9%) ERWINIA
Arthralgia (3%) Other
Asthenia (fatigue) (3–4%) Adverse effects [2] CHRYSANTHEMI
Pain in extremities (2%)
Gastrointestinal/Hepatic See: www.drugeruptiondata.com/drug/id/2697
Abdominal pain [2]
Constipation (5%)
ASPARAGINASE
Dyspepsia (3–4%) Synonym: L-asparaginase ASPARTAME
Vomiting (5%) Trade names: Elspar (Merck), Kidrolase (EUSA
Endocrine/Metabolic Pharma) See: www.drugeruptiondata.com/drug/id/49
Appetite increased (2–4%) Indications: Acute lymphoblastic leukemia,
Weight gain (3–5%) [12] lymphoma
Other Class: Antineoplastic, Enzyme
Adverse effects [4] Half-life: 830 hours (intravenous); 3449 hours
(intramuscular)
interactions with: none known
prescribing guidelines for: nursing mothers
Litt’s Drug Eruption & Reaction Manual ATAZANAVIR
Nasal polyp [4] romidepsin, rosuvastatin, salmeterol, saquinavir,

ASPIRIN Oral mucosal eruption [3] sildenafil, simeprevir, simvastatin, sirolimus,
Oral ulceration [4] sofosbuvir/velpatasvir/voxilaprevir, solifenacin,
Synonyms: acetylsalicylic acid; ASA sonidegib, St John’s wort, sunitinib, tacrolimus,
Trade names: Aggrenox (Boehringer Ingelheim), Central Nervous System
Stroke [2] tadalafil, telaprevir, telithromycin, temsirolimus,
Anacin (Wyeth), Ascriptin (Novartis) (Wallace), tenofovir disoproxil, ticagrelor, tipranavir,
Darvon Compound (aaiPharma), Durlaza (New Gastrointestinal/Hepatic trazodone, triazolam, tricyclic antidepressants,
Haven), Ecotrin (GSK), Equagesic (Women First), Black stools [3] vardenafil, vemurafenib, verapamil, voriconazole,
Excedrin (Bristol-Myers Squibb), Fiorinal Gastritis [2] warfarin
(Watson), Norgesic (3M), Soma Compound Gastrointestinal bleeding [8] Pregnancy category: B
(MedPointe), Talwin Compound (Sanofi-Aventis), Gastrointestinal ulceration [7] Important contra-indications noted in the
Yosprala (Aralez) Hepatotoxicity [4] prescribing guidelines for: the elderly; nursing
Indications: Pain, fever, inflammation Pancreatitis [2] mothers; pediatric patients
Class: Antiplatelet, Non-steroidal anti- Respiratory Note: Evotaz is atazanavir and cobicistat.
inflammatory (NSAID), Salicylate Asthma [10]
Half-life: 1520 minutes Pulmonary toxicity [2]
Clinically important, potentially hazardous Skin
Rhinitis [3] Jaundice (5–7%) [11]
interactions with: acemetacin, acenocoumarol, Sinusitis [2]
amitriptyline, anagrelide, anticoagulants, azficel-t, Rash (3–20%) [7]
bismuth, calcium hydroxylapatite, capsicum, Renal Cardiovascular
celecoxib, cholestyramine, cilazapril, citalopram, Fanconi syndrome [2] QT prolongation [2]
desvenlafaxine, devil’s claw, dexamethasone, Hematologic Torsades de pointes [2]
dexibuprofen, dichlorphenamide, diclofenac, Bleeding [12] Central Nervous System
dicumarol, duloxetine, enoxaparin, etodolac, Otic Depression (2%)
evening primrose, flunisolide, flurbiprofen, ginkgo Tinnitus [17] Fever (2%)
biloba, ginseng, heparin, ibuprofen, iloprost, Headache (<6%) [3]
indomethacin, ketoprofen, ketorolac, Ocular
Periorbital edema [3] Insomnia (3%)
lumiracoxib, meloxicam, methotrexate, methyl Neurotoxicity [2]
salicylate, methylprednisolone, milnacipran, Other Pain (3%)
nilutamide, NSAIDs, paroxetine hydrochloride, Adverse effects [9] Vertigo (dizziness) (3%)
phellodendron, piroxicam, prednisone, Allergic reactions [2]
resveratrol, reteplase, rivaroxaban, sermorelin, Neuromuscular/Skeletal
sulfites, tinzaparin, tirofiban, tolmetin, Asthenia (fatigue) (2%)
triamcinolone, urokinase, valdecoxib, valproic Back pain (2%)
acid, venlafaxine, verapamil, vilazodone, warfarin,
ASTEMIZOLE Myalgia/Myopathy (4%)
zafirlukast See: www.drugeruptiondata.com/drug/id/1308 Gastrointestinal/Hepatic
Pregnancy category: D Abdominal pain (4%)
Important contra-indications noted in the Cholelithiasis (gallstones) [4]
prescribing guidelines for: nursing mothers; Diarrhea (2%) [3]
pediatric patients ATAZANAVIR Hepatotoxicity [3]
Note: NSAIDs may cause an increased risk of Nausea (6–14%) [4]
serious cardiovascular and gastrointestinal Trade names: Evotaz (Bristol-Myers Squibb), Vomiting (3–4%)
adverse events, which can be fatal. This risk may Reyataz (Bristol-Myers Squibb)
Indications: HIV infection Respiratory
increase with duration of use. Upper respiratory tract infection [2]
Aggrenox is aspirin and dipyridamole; Yosprala is Class: Antiretroviral, HIV-1 protease inhibitor
aspirin and omeprazole. Half-life: 7 hours Endocrine/Metabolic
Clinically important, potentially hazardous ALT increased (3%)
interactions with: abiraterone, alfuzosin, AST increased (3%)
Skin amiodarone, antacids, aripiprazole, artemether/ Creatine phosphokinase increased (8%)
Anaphylactoid reactions/Anaphylaxis lumefantrine, atorvastatin, avanafil, bepridil, Hyperbilirubinemia [6]
(<10%) [8] bosentan, buprenorphine, cabazitaxel,
Angioedema (<5%) [32] Genitourinary
cabozantinib, calcifediol, cisapride, Urolithiasis [4]
Bullous dermatitis [4] clarithromycin, colchicine, crizotinib,
Erythema multiforme [9] cyclosporine, darifenacin, dasatinib, Renal
Erythema nodosum [9] dexlansoprazole, diltiazem, dofetilide, efavirenz, Nephrolithiasis [5]
Erythroderma [2] elbasvir & grazoprevir, eluxadoline, ergot Nephrotoxicity [6]
Exanthems [11] derivatives, erlotinib, estrogens, etravirine, Hematologic
Fixed eruption [22] everolimus, famotidine, felodipine, fentanyl, Neutropenia (5%)
Hypersensitivity [5] fesoterodine, flibanserin, fluticasone propionate,
Lichenoid eruption [2] Other
garlic, glecaprevir & pibrentasvir, indinavir, Adverse effects [5]
Pityriasis rosea [3] irinotecan, itraconazole, ixabepilone,
Pruritus [6] Infection (~50%)
ketoconazole, lapatinib, lidocaine, lopinavir,
Psoriasis [3] lovastatin, maraviroc, marihuana, midazolam,
Purpura [8] mifepristone, naldemedine, nevirapine,
Rash (<10%) nicardipine, nifedipine, olaparib, ombitasvir/
Stevens-Johnson syndrome [6] paritaprevir/ritonavir, omeprazole, oral
Toxic epidermal necrolysis [9] contraceptives, paclitaxel, pantoprazole,
Urticaria (<10%) [72] pazopanib, pimozide, posaconazole, proton-
Vasculitis [2] pump inhibitors, quetiapine, quinidine, quinine,
Mucosal rabeprazole, raltegravir, ranolazine, rifabutin,
Aphthous stomatitis [3] rifampin, rilpivirine, ritonavir, rivaroxaban,
ATENOLOL Over 100 updates per week on www.drugeruptiondata.com
Local
ATENOLOL ATEZOLIZUMAB Infusion-related reactions (3%)
Trade names: Beta-Adalat (Bayer), Kalten (BPC), Trade name: Tecentriq (Genentech) Other
Tenif (AstraZeneca), Tenoret 50 (AstraZeneca), Indications: Locally advanced or metastatic Adverse effects [3]
Tenoretic (AstraZeneca), Tenormin urothelial carcinoma in patients having disease Infection (38%)
(AstraZeneca) progression following platinum-containing
Indications: Angina, hypertension, acute chemotherapy
myocardial infarction Class: Monoclonal antibody, Programmed death- ATOMOXETINE
Class: Antiarrhythmic class II, Beta adrenergic ligand (PD-L1) inhibitor
blocker, Beta blocker Half-life: 27 days Trade name: Strattera (Lilly)
Half-life: 67 hours (adults) Clinically important, potentially hazardous Indications: Attention deficit hyperactivity
Clinically important, potentially hazardous interactions with: none known disorder
interactions with: alfuzosin, calcium channel Pregnancy category: N/A (Can cause fetal Class: Norepinephrine reuptake inhibitor
blockers, cisplatin, clonidine, digitalis glycosides, harm) Half-life: 5 hours
diltiazem, disopyramide, epinephrine, Important contra-indications noted in the Clinically important, potentially hazardous
indomethacin, reserpine, verapamil prescribing guidelines for: nursing mothers; interactions with: albuterol, amitriptyline,
Pregnancy category: D pediatric patients cinacalcet, citalopram, delavirdine, droperidol,
Important contra-indications noted in the duloxetine, levalbuterol, levomepromazine,
prescribing guidelines for: the elderly; nursing Skin linezolid, lisdexamfetamine, MAO inhibitors,
mothers; pediatric patients Peripheral edema (18%) moxifloxacin, paroxetine hydrochloride, sotalol,
Note: Contra-indicated in patients with sinus Pruritus (13%) [2] terbinafine, terbutaline, tipranavir, venlafaxine,
bradycardia, heart block greater than first degree, Rash (15%) [3] zuclopenthixol
cardiogenic shock, or overt cardiac failure. Beta- Pregnancy category: C
Adalat and Tenif are atenolol and nifedipine. Cardiovascular Important contra-indications noted in the
Kalten, Tenoret 50 and Tenoretic are atenolol and Venous thromboembolism (>2%) prescribing guidelines for: nursing mothers;
chlorthalidone. Chlorthalidone is a sulfonamide Central Nervous System pediatric patients
and can be absorbed systemically. Sulfonamides Fever (21%) Warning: SUICIDAL IDEATION IN CHILDREN
can produce severe, possibly fatal, reactions such Neuromuscular/Skeletal AND ADOLESCENTS
as toxic epidermal necrolysis and Stevens-Johnson Arthralgia (14%)
syndrome. Asthenia (fatigue) (52%) [3] Skin
Warning: CESSATION OF THERAPY Back pain (15%) Pruritus (>2%)
Neck pain (15%) Mucosal
Skin Gastrointestinal/Hepatic Xerostomia (>5%) [9]
Anaphylactoid reactions/Anaphylaxis [2] Abdominal pain (17%)
Lupus erythematosus [2] Cardiovascular
Colitis [2] Cardiotoxicity [2]
Necrosis [3] Constipation (21%)
Pruritus (<5%) Tachycardia [2]
Diarrhea (18%)
Psoriasis [7] Gastric obstruction (>2%) Central Nervous System
Raynaud’s phenomenon [2] Nausea (25%) Aggression [3]
Urticaria [2] Vomiting (17%) Anorexia [5]
Cardiovascular Depression (>2%) [3]
Respiratory Headache [9]
Atrial fibrillation (5%) [2] Cough (14%)
Atrial flutter (2%) Hypomania [2]
Dyspnea (16%) Insomnia [7]
Bradycardia (3–18%) [8] Pneumonia (>2%)
Cardiac arrest (2%) Irritability [8]
Pneumonitis (3%) Mania [2]
Cardiac failure (19%)
Heart block (5%) Endocrine/Metabolic Mood changes [5]
Hypotension (25%) [2] ALP increased (4%) Nervousness [3]
Postural hypotension (12%) ALT increased (2%) [2] Somnolence (drowsiness) [11]
Supraventricular tachycardia (12%) Appetite decreased (26%) Suicidal ideation [6]
Ventricular tachycardia (16%) AST increased (2%) [3] Tic disorder [7]
Dehydration (>2%) Tremor (>2%) [2]
Central Nervous System Diabetes mellitus [2] Vertigo (dizziness) (>5%) [10]
Depression (12%) Hyperglycemia (5%)
Somnolence (drowsiness) (2%) Neuromuscular/Skeletal
Hyperthyroidism (2%) Asthenia (fatigue) [11]
Stroke [2] Hyponatremia (10%)
Syncope [2] Hypothyroidism (6%) Gastrointestinal/Hepatic
Vertigo (dizziness) (15%) Serum creatinine increased (3%) Abdominal pain [12]
Neuromuscular/Skeletal Constipation [2]
Genitourinary Dyspepsia [3]
Asthenia (fatigue) (26%) Hematuria (14%)
Leg pain (3%) Hepatotoxicity [12]
Urinary tract infection (22%) Nausea [18]
Gastrointestinal/Hepatic Renal Vomiting [10]
Diarrhea (3%) Nephrotoxicity (>2%)
Nausea (3%) Endocrine/Metabolic
Hematologic Appetite decreased [27]
Respiratory Anemia (8%) Weight loss [5]
Dyspnea (6%) Lymphopenia (10%)
Wheezing (3%) Genitourinary
Sepsis (>2%) Erectile dysfunction [4]
Other Urinary hesitancy [2]
Adverse effects [5]
Litt’s Drug Eruption & Reaction Manual ATROPINE SULFATE
Other Mucosal
Adverse effects [10] Cheilitis (<2%) ATOVAQUONE/
Bruxism [2] Glossitis (<2%)
Oral ulceration (<2%)
PROGUANIL
Stomatitis (<2%)
Trade name: Malarone (GSK)
ATORVASTATIN Cardiovascular Indications: Malaria prophylaxis and treatment
Hypotension [2] Class: Antimalarial
Trade names: Caduet (Pfizer), Lipitor (Pfizer), Central Nervous System Half-life: 24 hours
Liptruzet (Merck Sharpe & Dohme) Ageusia (taste loss) (<2%) Clinically important, potentially hazardous
Indications: Hypercholesterolemia Cognitive impairment [2] interactions with: artemether/lumefantrine,
Class: HMG-CoA reductase inhibitor, Statin Depression [3] dapsone, etoposide, hypoglycemic agents,
Half-life: 14 hours Dysgeusia (taste perversion) (<2%) indinavir, metoclopramide, phenothiazines,
Clinically important, potentially hazardous Headache [4] rifabutin, rifampin, ritonavir, tetracycline, typhoid
interactions with: alcohol, aliskiren, Neurotoxicity [2] vaccine
amiodarone, amprenavir, antifungals, atazanavir, Paresthesias (<2%) Pregnancy category: C
azithromycin, bexarotene, boceprevir, bosentan, Parosmia (<2%) Important contra-indications noted in the
ciprofibrate, clarithromycin, clopidogrel, prescribing guidelines for: the elderly; nursing
cobicistat/elvitegravir/emtricitabine/tenofovir Neuromuscular/Skeletal mothers
alafenamide, cobicistat/elvitegravir/emtricitabine/ Arthralgia (4–12%)
tenofovir disoproxil, colchicine, conivaptan, Asthenia (fatigue) [5]
Back pain [3] Skin
cyclosporine, CYP3A4 inhibitors, dabigatran,
Muscle spasm [2] Erythema multiforme [2]
danazol, daptomycin, darunavir, dasatinib,
Myalgia/Myopathy (3–8%) [30] Pruritus (<10%)
delavirdine, digoxin, diltiazem, dronedarone,
efavirenz, elbasvir & grazoprevir, eltrombopag, Pain in extremities (6%) Mucosal
erythromycin, estradiol, etravirine, everolimus, Rhabdomyolysis [41] Oral ulceration (6%) [3]
fenofibrate, fenofibric acid, fibrates, fluconazole, Tendinopathy/Tendon rupture [2] Central Nervous System
fosamprenavir, fusidic acid, gemfibrozil, Gastrointestinal/Hepatic Abnormal dreams (7%)
glecaprevir & pibrentasvir, grapefruit juice, Cholelithiasis (gallstones) [2] Anorexia (5%)
imatinib, imidazoles, indinavir, itraconazole, Diarrhea (5–14%) Headache (10%) [4]
liraglutide, lopinavir, macrolide antibiotics, Hepatitis [2] Insomnia (3%)
midazolam, nefazodone, nelfinavir, niacin, Hepatotoxicity [11] Vertigo (dizziness) (5%) [3]
niacinamide, norethisterone, oral contraceptives, Nausea (4–7%)
P-glycoprotein inhibitors, posaconazole, protease Pancreatitis [8]
Asthenia (fatigue) (8%)
inhibitors, quinine, red rice yeast, rifampin, Respiratory
ritonavir, rivaroxaban, saquinavir, silodosin, St Gastrointestinal/Hepatic
Nasopharyngitis (4–13%)
John’s wort, telaprevir, telithromycin, tipranavir, Abdominal pain (17%) [5]
topotecan, trabectedin, verapamil, voriconazole, Endocrine/Metabolic Diarrhea (8%)
warfarin ALT increased [3] Dyspepsia (2%)
Pregnancy category: X Creatine phosphokinase increased [5] Gastritis (3%)
Important contra-indications noted in the Diabetes mellitus [2] Hepatotoxicity [2]
prescribing guidelines for: the elderly; nursing Gynecomastia (<2%) Nausea (12%)
mothers; pediatric patients Genitourinary Vomiting (12%) [2]
Note: Caduet is atorvastatin and amlodipine; Urinary tract infection (4–8%) Respiratory
Liptruzet is atorvastatin and ezetimibe. Cough [3]
Renal
Nephrotoxicity [3] Ocular
Skin Vision impaired (2%)
Otic
Acneform eruption (<2%)
Hearing loss [2] Other
Angioedema [2]
Dermatitis (<2%) Other Adverse effects [3]
Dermatomyositis [4] Adverse effects [10]
Diaphoresis (<2%) Allergic reactions (<2%)
Ecchymoses (<2%) Death [6] ATRACURIUM
Eczema (<2%) Multiorgan failure [2]
Edema (<2%) See: www.drugeruptiondata.com/drug/id/55
Facial edema (<2%)
Jaundice [2] ATOVAQUONE
Lupus erythematosus [2]
Petechiae (<2%)
ATROPINE SULFATE
Photosensitivity (<2%) Trade name: Lomotil (Pfizer)
Pruritus (<2%) Indications: Salivation, sinus bradycardia, uveitis,
Rash (>3%) [2] peptic ulcer
Seborrhea (<2%) Class: Muscarinic antagonist
Toxic epidermal necrolysis [2] Half-life: 23 hours
Toxicity [2] Clinically important, potentially hazardous
Ulcerations (<2%) interactions with: anticholinergics,
Urticaria (<2%) zuclopenthixol
Xerosis (<2%) Pregnancy category: C
Hair Note: Many of the trade name drugs for atropine
Alopecia (<2%) sulfate contain phenobarbital, scopolamine,
hyoscyamine, hydrocodone, methenamine, etc.
ATROPINE SULFATE See all our books at www.crcpress.com
Respiratory
Skin
Anaphylactoid reactions/Anaphylaxis [3] Bronchitis (<2%) AXITINIB
Dermatitis [3] Influenza (<2%)
Nasopharyngitis (<5%) [5] Trade name: Inlyta (Pfizer)
Erythema multiforme [2] Indications: Advanced renal cell carcinoma (after
Photosensitivity (<10%) Sinusitis (<2%) [2]
Upper respiratory tract infection (<3%) failure of one prior systemic therapy)
Mucosal Class: Tyrosine kinase inhibitor
Xerostomia (>10%) [4]
Other Half-life: 2–6 hours
Adverse effects [4] Clinically important, potentially hazardous
Cardiovascular
interactions with: ketoconazole, rifampin
Arrhythmias [2]
Atrial fibrillation [2]
Bradycardia [3] AVELUMAB * Important contra-indications noted in the
Tachycardia [5]
Trade name: Bavencio (Merck Serono) pediatric patients
Central Nervous System Indications: Metastatic Merkel cell carcinoma
Confusion [2] Class: Monoclonal antibody, Programmed death- Skin
Ocular ligand (PD-L1) inhibitor Erythema (2%)
Amblyopia [5] Half-life: 6 days Hand–foot syndrome (27%) [15]
Hallucinations, visual [3] Clinically important, potentially hazardous Pruritus (7%)
Periocular dermatitis [3] interactions with: none known Rash (13%) [3]
Pregnancy category: N/A (Can cause fetal Xerosis (10%)
Local
harm)
Injection-site irritation (>10%) Hair
Other prescribing guidelines for: nursing mothers; Alopecia (4%) [2]
Allergic reactions [2] pediatric patients Mucosal
Central anticholinergic syndrome [2] Mucosal inflammation (15%) [2]
Skin Stomatitis (15%)
Peripheral edema (20%) Cardiovascular
AVANAFIL Pruritus (10%) Hypertension (40%) [34]
Rash (22%) Central Nervous System
Trade name: Stendra (Vivus)
Cardiovascular Anorexia [5]
Indications: Erectile dysfunction
Hypertension (13%) Dysgeusia (taste perversion) (11%)
Class: Phosphodiesterase type 5 (PDE5) inhibitor
Central Nervous System Headache (14%) [4]
Half-life: 5 hours
Headache (10%) Leukoencephalopathy [2]
interactions with: alcohol, alpha blockers, Vertigo (dizziness) (14%) Neuromuscular/Skeletal
amprenavir, antihypertensives, aprepitant, Neuromuscular/Skeletal Arthralgia (15%) [2]
atazanavir, clarithromycin, diltiazem, Arthralgia (16%) Asthenia (fatigue) (39%) [26]
erythromycin, fluconazole, fosamprenavir, Asthenia (fatigue) (50%) [3] Pain in extremities (13%)
indinavir, itraconazole, ketoconazole, nefazodone, Bone or joint pain (32%) Gastrointestinal/Hepatic
nelfinavir, nitrates, ritonavir, saquinavir, strong Abdominal pain (14%)
CYP3A4 inhibitors, telithromycin, verapamil
Abdominal pain (16%) Constipation (20%) [2]
Pregnancy category: C (Not indicated for use in Diarrhea (55%) [25]
women)
Colitis (2%)
Constipation (17%) Dyspepsia (10%)
Important contra-indications noted in the Nausea (32%) [10]
Diarrhea (23%)
Nausea (22%) [2] Vomiting (24%) [6]
Note: Contra-indicated in patients using any form
of nitrates.
Vomiting (13%) Respiratory
Respiratory Cough (15%) [2]
Cough (18%) Dysphonia (>20%) [12]
Skin Dyspnea (15%) [4]
Facial flushing [2] Dyspnea (11%)
Rash (<2%) Endocrine/Metabolic Endocrine/Metabolic
ALT increased (20%) ALT increased (22%) [2]
Mucosal Appetite decreased (34%) [7]
Nasal congestion (<3%) [7] Appetite decreased (20%)
AST increased (34%) [2] AST increased [2]
Cardiovascular Creatine phosphokinase increased [3] Dehydration [2]
Flushing (3–10%) [10] Hyperamylasemia (8%) Hyperthyroidism [2]
Hypertension (<2%) Hyperbilirubinemia (6%) Hyponatremia [2]
Hyperglycemia (>10%) Hypothyroidism (19%) [8]
Thyroid dysfunction (6%) Serum creatinine increased [2]
Weight loss (15%) Thyroid dysfunction [2]
Vertigo (dizziness) (<2%) [2]
Weight loss (25%) [3]
Arthralgia (<2%) Anemia (35%) Renal
Hyperlipasemia (14%) Proteinuria (11%) [5]
Back pain (<3%) [3] Lymphopenia (49%) Hematologic
Neutropenia (6%) Anemia [2]
Thrombocytopenia (27%) Hemorrhage (16%)
Constipation (<2%)
Local Neutropenia [2]
Diarrhea (<2%)
Infusion-related reactions (22%) [3] Thrombotic complications (3%)
Dyspepsia (<2%) [4]
Nausea (<2%)
Litt’s Drug Eruption & Reaction Manual AZATHIOPRINE
Other Cerebral hemorrhage (<5%) Injection-site erythema (35–43%)

Adverse effects [4] Depression (12%) Injection-site hematoma (6%)
Fever (30–52%) [4] Injection-site pain (19–23%)
Headache (22%) Injection-site pigmentation (5%)
Insomnia (9–11%) Injection-site pruritus (7%)
AZACITIDINE Intracranial hemorrhage (<5%) Injection-site purpura (14%)
Trade name: Vidaza (Celgene) Pain (11%) Injection-site reactions (14–29%) [7]
Indications: Myelodysplastic syndromes, Seizures (<5%) Other
refractory anemia Syncope [2] Adverse effects [5]
Class: Antimetabolite, Antineoplastic, Cytosine Vertigo (dizziness) (19%) Death [4]
analog Neuromuscular/Skeletal Infection (<5%) [9]
Half-life: 40–56 minutes Arthralgia (22%) [2]
Clinically important, potentially hazardous Asthenia (fatigue) (7–36%) [4]
interactions with: BCG vaccine, denosumab,
echinacea, leflunomide, natalizumab,
Back pain (19%)
Bone or joint pain (<5%)
AZATADINE
pimecrolimus, sipuleucel-T, tacrolimus, Myalgia/Myopathy (16%) See: www.drugeruptiondata.com/drug/id/59
trastuzumab, vaccines Neck pain (<5%)
Pregnancy category: D Gastrointestinal/Hepatic
Abdominal pain (12–13%)
Black stools (<5%)
AZATHIOPRINE
pediatric patients Cholecystitis (<5%)
Note: Contra-indicated in patients with advanced Trade names: Azasan (aaiPharma), Imuran
Constipation (34–50%) [4] (Prometheus)
malignant hepatic tumors. Diarrhea (36%) [4] Indications: Lupus nephritis, psoriatic arthritis,
Dyspepsia (6%) rheumatoid arthritis, autoimmune diseases, as an
Skin Dysphagia (5%) adjunct for the prevention of rejection in kidney
Anaphylactoid reactions/Anaphylaxis (<5%) Gastrointestinal bleeding (<5%) transplant patients
Cellulitis (8%) Loose stools (6%) Class: Antimetabolite, Disease-modifying
Diaphoresis (11%) Nausea (48–71%) [6] antirheumatic drug (DMARD),
Ecchymoses (31%) Vomiting (27–54%) [4] Immunosuppressant, Purine anaolog
Edema (14%) Respiratory Half-life: 12 minutes
Erythema (7–17%) Cough (30%) Clinically important, potentially hazardous
Hematoma (9%) Dyspnea (14–29%) [2] interactions with: allopurinol, aminosalicylates,
Herpes simplex (9%) Hemoptysis (<5%) balsalazide, benazepril, captopril, chlorambucil,
Hypersensitivity (<5%) Nasopharyngitis (15%) co-trimoxazole, cyclophosphamide, cyclosporine,
Induration (<5%) Pharyngolaryngeal pain (6%) enalapril, febuxostat, fosinopril, Hemophilus B
Lymphoproliferative disease [2] Pneumonia (11%) [2] vaccine, imidapril, lisinopril, mesalamine,
Neoplasms (<5%) Pneumonitis (<5%) [2] mycophenolate, natalizumab, olsalazine, quinapril,
Nodular eruption (5%) Pulmonary toxicity [2] ramipril, ribavirin, sulfamethoxazole, tofacitinib,
Pallor (16%) Respiratory distress (<5%) trimethoprim, typhoid vaccine, vaccines, warfarin,
Peripheral edema (19%) Rhinitis (6%) yellow fever vaccine
Petechiae (11–24%) Upper respiratory tract infection (9–13%) Pregnancy category: D
Pruritus (12%) Important contra-indications noted in the
Pyoderma gangrenosum (<5%) Endocrine/Metabolic
Dehydration (<5%) prescribing guidelines for: nursing mothers;
Rash (10–14%) [4] pediatric patients
Sweet’s syndrome [4] Hypokalemia (6%)
Weight loss (8%) Note: Patients receiving immunosuppressants,
Toxicity [2] including azathioprine, are at increased risk of
Urticaria (6%) Genitourinary developing lymphoma and other malignancies,
Xerosis (5%) Hematuria (6%) particularly of the skin.
Mucosal Urinary tract infection (9%) Warning: MALIGNANCY
Gingival bleeding (10%) Renal
Oral bleeding (5%) Renal failure (<5%) Skin
Stomatitis (8%) Hematologic Acanthosis nigricans [2]
Tongue ulceration (5%) Agranulocytosis (<5%) Acneform eruption [2]
Cardiovascular Anemia (51–70%) [4] AGEP [2]
Arrhythmias [2] Bleeding [3] Angioedema [2]
Atrial fibrillation (<5%) Bone marrow suppression (<5%) Basal cell carcinoma [2]
Cardiac failure (<5%) Cytopenia [4] Carcinoma [3]
Cardiomyopathy (<5%) Febrile neutropenia (14–16%) [6] Dermatitis [4]
Cardiotoxicity [3] Leukopenia (18–48%) Erythema gyratum repens [2]
Chest pain (5–16%) [4] Myelosuppression [3] Erythema multiforme [2]
Congestive heart failure (<5%) Neutropenia (32–66%) [7] Erythema nodosum [4]
Hypertension (9%) Pancytopenia (<5%) Exanthems [10]
Hypotension (7%) [2] Splenomegaly (<5%) Herpes simplex [3]
Orthostatic hypotension (<5%) Thrombocytopenia (66–70%) [4] Herpes zoster [8]
QT prolongation [2] Ocular Hypersensitivity [28]
Tachycardia [3] Ocular hemorrhage (<5%) Kaposi’s sarcoma [14]
Central Nervous System Lymphoproliferative disease [4]
Local Neoplasms [2]
Anorexia (21%) Injection-site bruising (5–14%)
Anxiety (5–13%) Neutrophilic dermatosis [4]
Injection-site edema (5%)
AZATHIOPRINE Over 100 updates per week on www.drugeruptiondata.com
Nevi [3] Allergic reactions [5] Churg-Strauss syndrome [2]

Porokeratosis [4] Death [2] DRESS syndrome [4]
Rash (<10%) [10] Infection [9] Erythema [2]
Scabies [5] Exanthems [3]
Squamous cell carcinoma [11] Hypersensitivity [3]
Sweet’s syndrome [12]
Tinea [3]
AZELASTINE Jarisch–Herxheimer reaction [2]
Pruritus [3]
Toxicity [3] See: www.drugeruptiondata.com/drug/id/61 Rash [Ophth] (2–10%) [6]
Tumors [8] Stevens-Johnson syndrome [6]
Urticaria [5] Urticaria [Ophth] [2]
Vasculitis [5] Cardiovascular
Verrucae [3] AZFICEL-T Bradycardia [2]
Hair See: www.drugeruptiondata.com/drug/id/2617 Cardiotoxicity [8]
Alopecia [9] QT prolongation [11]
Nails Torsades de pointes [4]
Onychomycosis [2] AZILSARTAN Central Nervous System
Mucosal Anorexia (2–10%)
Oral ulceration [2] See: www.drugeruptiondata.com/drug/id/2275 Headache [3]
Cardiovascular
Atrial fibrillation [3] Gastrointestinal/Hepatic
Central Nervous System AZITHROMYCIN Abdominal pain (2–10%) [4]
Diarrhea (4–9%) [17]
Chills (>10%) Gastrointestinal disorder [2]
Fever [7] Trade names: AzaSite (Merck), Zithromax
(Pfizer) Hepatotoxicity [7]
Headache [3] Nausea (7%) [8]
Indications: Infections of the upper and lower
Leukoencephalopathy [2] Vanishing bile duct syndrome [2]
respiratory tract, skin infections, sexually
Neuromuscular/Skeletal transmitted diseases, conjunctivitis (ophthalmic Vomiting (2–10%) [5]
Arthralgia [4] preparations only) Genitourinary
Asthenia (fatigue) [7] Class: Antibacterial, Antibiotic, macrolide Vaginitis (2–10%)
Gastrointestinal/Hepatic Half-life: 68 hours Otic
Abdominal pain [2] Clinically important, potentially hazardous Hearing loss [3]
Hepatitis [5] interactions with: aminophylline, antacids, Tinnitus [2]
Hepatotoxicity [27] artemether/lumefantrine, astemizole,
Nausea [8] atorvastatin, betrixaban, bromocriptine, Ocular
Pancreatitis [44] cabergoline, colchicine, coumarins, cyclosporine, Keratitis [2]
Vomiting [4] digoxin, droperidol, ergotamine, fluvastatin, Local
lovastatin, methysergide, mizolastine, oral typhoid Injection-site erythema (2–10%)
Respiratory
vaccine, pimozide, pravastatin, quetiapine, Injection-site pain (2–10%) [3]
Flu-like syndrome [2]
reboxetine, rifabutin, ritonavir, simvastatin,
Pneumonitis [2] Other
venetoclax, warfarin
Pulmonary toxicity [3] Adverse effects [14]
Hematologic Death [2]
Bone marrow suppression [5] Hiccups [2]
Leukopenia [12] Side effects [2]
pediatric patients
Myelosuppression [2] Note: AzaSite is for topical ophthalmic use only
Myelotoxicity [5] (for reactions see [Ophth] below).
Neutropenia [2] AZTREONAM
Pancytopenia [4]
Skin
Thrombocytopenia [5] See: www.drugeruptiondata.com/drug/id/63
AGEP [3]
Other Anaphylactoid reactions/Anaphylaxis [2]
Adverse effects [7]
Litt’s Drug Eruption & Reaction Manual BASILIXIMAB
Other Skin
BACAMPICILLIN Infection [2] Acneform eruption (>10%)
Side effects (<2%) Candidiasis (3–10%)
See: www.drugeruptiondata.com/drug/id/64 Cyst (310%)
Edema (generalized) (310%)
BACITRACIN BALSALAZIDE Facial edema (310%)

Genital edema (310%)
Trade names: Colazal (Salix), Colazide (Almirall) Hematoma (310%)
See: www.drugeruptiondata.com/drug/id/1199 Indications: Mild to moderately active ulcerative Herpes simplex (310%)
colitis Herpes zoster (3–10%)
Class: Aminosalicylate Peripheral edema (>10%)
BACLOFEN Half-life: N/A Pruritus (310%)
Rash (310%)
Trade names: Baclofen (Watson), Gablofen interactions with: azathioprine, cardiac Ulcerations (310%)
(Mallinckrodt), Lioresal (Medtronic) glycosides, folic acid, heparin, low molecular Wound complications (>10%)
Indications: Spasticity resulting from multiple weight heparins, mercaptopurine, thiopurine Hair
sclerosis analogs, varicella virus-containing vaccines Hypertrichosis (310%)
Class: GABA receptor agonist, Skeletal muscle Pregnancy category: B Mucosal
relaxant Important contra-indications noted in the Gingival hyperplasia/hypertrophy (310%)
Half-life: 2.54 hours prescribing guidelines for: nursing mothers; Stomatitis (310%)
Clinically important, potentially hazardous pediatric patients Ulcerative stomatitis (3–10%)
interactions with: acebutolol, alcohol, alfuzosin,
amitriptyline, captopril, cilazapril, diclofenac, Cardiovascular
Skin Angina (3–10%)
enalapril, fosinopril, irbesartan, levodopa, Hypersensitivity [2]
lisinopril, meloxicam, olmesartan, quinapril, Arrhythmias (3–10%)
ramipril, trandolapril Mucosal Atrial fibrillation (3–10%)
Pregnancy category: C Stomatitis (3%) Cardiac failure (3–10%)
Important contra-indications noted in the Central Nervous System Chest pain (3–10%)
prescribing guidelines for: pediatric patients Anorexia (2%) Hypertension (>10%)
Note: Children appear to be at higher risk for Fever (2–6%) Hypotension (3–10%)
complications than adults when using intrathecal Headache (15%) Pulmonary edema (3–10%)
baclofen (ITB). ITB therapy is a safe and effective Insomnia (2%) Tachycardia (3–10%)
treatment for severe spasticity in the pediatric Neuromuscular/Skeletal Central Nervous System
population, but does have a 31% rate of Arthralgia (4%) Agitation (3–10%)
complications requiring surgical management Asthenia (fatigue) (2%) Anxiety (3–10%)
over a 3-year treatment period. Depression (310%)
Warning: DO NOT DISCONTINUE Gastrointestinal/Hepatic Fever (>10%)
ABRUPTLY Abdominal pain (6–13%) Headache (>10%)
Colitis (ulcerative, exacerbation) (6%) Hypoesthesia (3–10%)
Diarrhea (5–9%) Insomnia (>10%)
Skin Dyspepsia (2%)
Exanthems [2] Pain (>10%)
Flatulence (2%) Paresthesias (310%)
Rash (<10%) Nausea (4%)
Toxicity [2] Rigors (3–10%)
Vomiting (10%) Tremor (>10%)
Cardiovascular Respiratory Vertigo (dizziness) (3–10%)
Bradycardia [2] Cough (2–3%)
Hypertension [2] Neuromuscular/Skeletal
Flu-like syndrome (<4%) Arthralgia (310%)
Hypotension [3] Nasopharyngitis (6%) Asthenia (fatigue) (3–10%)
Central Nervous System Pharyngitis (2%) Back pain (3–10%)
Coma [3] Pharyngolaryngeal pain (3%) Cramps (3–10%)
Confusion (<10%) Rhinitis (2%) Fractures (3–10%)
Dyskinesia [2] Genitourinary Leg pain (3–10%)
Encephalopathy [2] Dysmenorrhea (3%) Myalgia/Myopathy (310%)
Hallucinations [4]
Headache (<10%) Gastrointestinal/Hepatic
Insomnia (>10%) Abdominal distension (3–10%)
Seizures [9] BASILIXIMAB Abdominal pain (>10%)
Slurred speech (>10%) Black stools (3–10%)
Somnolence (drowsiness) (>10%) [6] Trade name: Simulect (Novartis) Constipation (>10%)
Vertigo (dizziness) (>10%) [5] Indications: Prophylaxis of organ rejection in Diarrhea (>10%)
renal transplantation Dyspepsia (>10%)
Neuromuscular/Skeletal Class: Interleukin-2 receptor antagonist, Esophagitis (3–10%)
Asthenia (fatigue) (>10%) [6] Monoclonal antibody Flatulence (3–10%)
Gastrointestinal/Hepatic Half-life: 7.2 days Gastroenteritis (3–10%)
Constipation (<10%) Clinically important, potentially hazardous Gastrointestinal bleeding (3–10%)
Nausea (<10%) interactions with: cyclosporine, Hemophilus B Gastrointestinal disorder (69%)
Genitourinary vaccine, mycophenolate Hernia (3–10%)
Polyuria (<10%) Pregnancy category: B Nausea (>10%)
Important contra-indications noted in the Vomiting (>10%)
BASILIXIMAB See all our books at www.crcpress.com
Respiratory monosodium glutamate, moxifloxacin, ofloxacin,

Bronchitis (3–10%) oxaliplatin, pazopanib, sulfadiazine, telavancin, BECLOMETHASONE
Bronchospasm (3–10%) telithromycin, temsirolimus
Cough (3–10%) Pregnancy category: C Trade names: Beconase AQ (GSK), Qnasl
Dyspnea (>10%) (Teva), Qvar (3M), Vanceril (Schering)
Pharyngitis (3–10%) Indications: Allergic rhinitis, asthma
Skin Class: Corticosteroid, inhaled
Pneumonia (3–10%) Abscess [16]
Rhinitis (3–10%) Half-life: N/A
Anaphylactoid reactions/Anaphylaxis [5] Clinically important, potentially hazardous
Sinusitis (3–10%) Churg-Strauss syndrome [15]
Upper respiratory tract infection (>10%) interactions with: diuretics, estrogens,
Dermatitis [2] ketoconazole, live vaccines, oral contraceptives,
Endocrine/Metabolic Erythema [3] phenytoin, rifampin, warfarin
Acidosis (3–10%) Fixed eruption [2] Pregnancy category: C
Dehydration (3–10%) Hypersensitivity [2] Important contra-indications noted in the
Diabetes mellitus (3–10%) Keloid [4] prescribing guidelines for: nursing mothers;
Hypercalcemia (3–10%) Lupus vulgaris [22] pediatric patients
Hypercholesterolemia (>10%) Lymphadenitis [8]
Hyperglycemia (>10%) Lymphadenopathy [92]
Hyperkalemia (>10%) Papular lesions [6] Skin
Hyperlipidemia (3–10%) Sarcoidosis [4] Bruising [3]
Hypertriglyceridemia (3–10%) Scar [8] Candidiasis [2]
Hyperuricemia (>10%) Scrofuloderma [5] Mucosal
Hypocalcemia (3–10%) Sweet’s syndrome [2] Epistaxis (nosebleed) (with nasally-inhaled
Hypoglycemia (3–10%) Ulcerations [6] formulation) (2%)
Hypokalemia (>10%) Vasculitis [2] Nasal discomfort (5%)
Hypophosphatemia (>10%) Mucosal Oral candidiasis [4]
Weight gain (3–10%) Mucocutaneous lymph node syndrome Central Nervous System
Genitourinary (Kawaski syndrom) [2] Headache (2%) [2]
Albuminuria (3–10%) Central Nervous System Neuromuscular/Skeletal
Dysuria (3–10%) Fever [6] Osteoporosis [5]
Hematuria (3–10%) Neurotoxicity [2]
Impotence (3–10%) Respiratory
Oliguria (3–10%) Neuromuscular/Skeletal Upper respiratory tract infection [2]
Urinary frequency (3–10%) Arthralgia [7] Ocular
Urinary retention (3–10%) Asthenia (fatigue) [4] Cataract [4]
Urinary tract infection (>10%) Osteomyelitis [33] Glaucoma [3]
Renal Gastrointestinal/Hepatic Other
Renal tubular necrosis (3–10%) Hepatitis [3] Adverse effects [10]
Hepatotoxicity [2]
Hematologic
Anemia (>10%) Genitourinary
Balanitis [3]
Hemorrhage (3–10%)
Bladder disorder [2]
BEDAQUILINE
Leukopenia (3–10%)
Polycythemia (3–10%) Hematuria [2] Trade name: Sirturo (Janssen)
Sepsis (3–10%) Hematologic Indications: Pulmonary multi-drug resistant
Thrombocytopenia (3–10%) Sepsis [3] tuberculosis
Thrombosis (3–10%) Ocular Class: Antimycobacterial, Diarylquinoline
Ocular Optic neuritis [2] Half-life: 5.5 months
Abnormal vision (3–10%) Uveitis [4] Clinically important, potentially hazardous
Cataract (3–10%) interactions with: ketoconazole, rifabutin,
Local rifampin, rifapentine, stong CYP3A4 inhibitors
Conjunctivitis (3–10%) Injection-site abscess [3] and inducers
Other Injection-site reactions [3] Pregnancy category: B
Infection (viral) (>10%) Injection-site ulceration [3] Important contra-indications noted in the
Other prescribing guidelines for: nursing mothers;
Adverse effects [3] pediatric patients
BCG VACCINE Cancer [3] Warning: INCREASED RISK OF DEATH / QT
Death [14] PROLONGATION
Synonym: Bacille Calmette-Guerin Infection [2]
Trade names: Mycobax (Sanofi-Aventis), TICE Systemic reactions [2] Skin
BCG (Organon) Rash (8%)
Indications: Immunization against tuberculosis
Cardiovascular
Class: Vaccine
Half-life: N/A
BECAPLERMIN Chest pain (11%) [2]
Clinically important, potentially hazardous QT prolongation [2]
interactions with: alefacept, aminophylline, Central Nervous System
azacitidine, betamethasone, cabazitaxel, cefazolin, Anorexia (9%)
cefixime, ceftaroline fosamil, ceftobiprole, Headache (28%) [3]
ciprofloxacin, demeclocycline, denileukin, Vertigo (dizziness) [2]
docetaxel, doripenem, doxycycline, fingolimod, Neuromuscular/Skeletal
gefitinib, gemifloxacin, leflunomide, levofloxacin,
Arthralgia (33%) [2]
Litt’s Drug Eruption & Reaction Manual BENAZEPRIL
Pain in extremities [2] Gastrointestinal/Hepatic Cardiovascular

Gastrointestinal/Hepatic Abdominal pain (9–19%) Hypotension (10%)
Hepatotoxicity [2] Constipation (33%) Phlebitis (10%)
Nausea (38%) [4] Diarrhea (39%) QT prolongation (11%) [2]
Vomiting [2] Nausea (24%) Central Nervous System
Vomiting (22%) Anorexia [2]
Respiratory
Hemoptysis (18%) Respiratory Chills (16%)
Bronchitis (10%) Fever (35%) [2]
Endocrine/Metabolic Cough (24%) Headache (15%) [3]
ALT increased (<10%) Dyspnea (12%) Peripheral neuropathy [2]
AST increased (<10%) Influenza (11%) Vertigo (dizziness) (10%) [2]
Hyperuricemia [2] Nasopharyngitis (13%) Neuromuscular/Skeletal
Otic Upper respiratory tract infection (15%) Asthenia (fatigue) (37%) [11]
Hearing loss [2] Endocrine/Metabolic Myalgia/Myopathy [2]
Other Creatine phosphokinase increased (15%) Gastrointestinal/Hepatic
Infection [3] Hypercholesterolemia (11%) Abdominal pain (11%)
Hyperglycemia (19%) Constipation (23%) [5]
Hyperkalemia (20%) Diarrhea (23%) [6]
BELATACEPT Hyperuricemia (5%)
Hypocalcemia (13%)
Nausea (42%) [10]
Vomiting (29%) [10]
Trade name: Nulojix (Bristol-Myers Squibb) Hypokalemia (21%)
Hypomagnesemia (7%) Respiratory
Indications: Prophylaxis of organ rejection in Cough (19%)
kidney transplantation Hypophosphatemia (19%)
Dyspnea (22%) [4]
Class: Immunosuppressant, T-cell co-stimulation Genitourinary Pneumonia (>2%)
blocker Dysuria (11%) Pneumonitis [2]
Half-life: 7–10 days Hematuria (16%)
Clinically important, potentially hazardous Urinary incontinence (<10%) Endocrine/Metabolic
interactions with: live vaccines, mycophenolate Urinary tract infection (37%) [2] Appetite decreased (15%)
Pregnancy category: C Creatine phosphokinase increased (>2%)
Renal Hypokalemia (12%)
Important contra-indications noted in the Proteinuria (16%)
prescribing guidelines for: nursing mothers; Renal failure (<10%) Hematologic
pediatric patients Renal tubular necrosis (9%) Anemia (32%) [5]
Note: Contra-indicated in patients without Leukopenia [2]
immunity to Epstein-Barr virus. Hematologic Lymphopenia [2]
Warning: POST-TRANSPLANT Anemia (45%) Neutropenia [4]
LYMPHOPROLIFERATIVE DISORDER, OTHER Dyslipidemia (19%) Thrombocytopenia (16%) [3]
MALIGNANCIES, AND SERIOUS INFECTIONS Leukopenia (20%) Thrombosis [2]
Neutropenia (<10%) [2]
Local
Skin Other Infusion-site pain (14%)
Acneform eruption (8%) Graft dysfunction (25%) Injection-site reactions [2]
Hematoma (<10%) Infection (<10%) [7]
Other
Hyperhidrosis (<10%) Allergic reactions [2]
Lymphoproliferative disease (post- Hiccups [2]
transplant) [7] BELIMUMAB Multiorgan failure (>2%)
Malignancies [3]
Peripheral edema (34%) See: www.drugeruptiondata.com/drug/id/2285
Hair
Alopecia (<10%)
BENACTYZINE
Mucosal BELINOSTAT See: www.drugeruptiondata.com/drug/id/66
Aphthous stomatitis (<10%)
Stomatitis (<10%) Trade name: Beleodaq (Spectrum)
Indications: Peripheral T-cell lymphoma
Cardiovascular Class: Histone deacetylase (HDAC) inhibitor BENAZEPRIL
Atrial fibrillation (<10%) Half-life: 1 hour
Hypertension (32%) Clinically important, potentially hazardous Trade names: Lotensin (Novartis), Lotensin
Hypotension (18%) interactions with: strong UGT1A1 inhibitors HCT (Novartis), Lotrel (Novartis)
Central Nervous System Pregnancy category: D Indications: Hypertension
Anxiety (10%) Important contra-indications noted in the Class: Angiotensin-converting enzyme (ACE)
Fever (28%) prescribing guidelines for: nursing mothers; inhibitor, Antihypertensive, Vasodilator
Guillain–Barré syndrome (<10%) pediatric patients Half-life: 10–11 hours
Headache (21%) Clinically important, potentially hazardous
Insomnia (15%) interactions with: allopurinol, amifostine,
Skin amiloride, angiotensin II receptor blockers,
Tremor (8%) Peripheral edema (20%) [2]
Vertigo (dizziness) (9%) antacids, antidiabetics, antihypertensives,
Pruritus (16%) azathioprine, cyclosporine, diazoxide, diuretics,
Neuromuscular/Skeletal Rash (20%) eplerenone, everolimus, gold & gold compounds,
Arthralgia (17%) Hair herbals, lithium, MAO inhibitors,
Back pain (13%) Alopecia [2] methylphenidate, NSAIDs, pentoxifylline,
Bone or joint pain (<10%) phosphodiesterase 5 inhibitors, potassium salts,
BENAZEPRIL Over 100 updates per week on www.drugeruptiondata.com
prostacyclin analogues, rituximab, sirolimus, Central Nervous System

spironolactone, temsirolimus, tizanidine, Anorexia (<5%) BERACTANT
tolvaptan, triamterene, trimethoprim, yohimbine Fever [6]
Pregnancy category: D Headache (<5%) [5] See: www.drugeruptiondata.com/drug/id/1166
Important contra-indications noted in the Neurotoxicity [2]
prescribing guidelines for: pediatric patients Peripheral neuropathy (2%)
Note: Lotrel is benazepril and amlodipine. Tremor (2%) BESIFLOXACIN
Lotensin-HCT is benazepril and Vertigo (dizziness) (4%)
hydrochlorothiazide. Hydrochlorothiazide is a Neuromuscular/Skeletal See: www.drugeruptiondata.com/drug/id/1422
sulfonamide and can be absorbed systemically. Arthralgia (<5%) [4]
Sulfonamides can produce severe, possibly fatal, Asthenia (fatigue) [5]
reactions such as toxic epidermal necrolysis and
Stevens-Johnson syndrome.
Myalgia/Myopathy [3] BETA-CAROTENE
Contra-indicated in patients with a history of Gastrointestinal/Hepatic
Abdominal distension [2] See: www.drugeruptiondata.com/drug/id/72
angioedema with or without previous ACE
inhibitor treatment. Abdominal pain (25%) [4]
Warning: FETAL TOXICITY Diarrhea [2]
Dyspepsia [2] BETAMETHASONE
Hepatotoxicity (5%) [2]
Skin Nausea [4] See: www.drugeruptiondata.com/drug/id/1101
Angioedema [8] Vomiting [2]
Peripheral edema [3]
Hematologic
Central Nervous System Eosinophilia [2] BETAXOLOL
Headache (6%) Neutropenia [2]
Vertigo (dizziness) (4%) Trade names: Betoptic [Ophthalmic] (Alcon),
Other
Respiratory Adverse effects [7] Kerlone (Pfizer)
Cough [10] Allergic reactions [2] Indications: Open-angle glaucoma, hypertension
Class: Adrenergic beta-receptor antagonist
Half-life: 1422 hours
BENDAMUSTINE BENZONATATE
interactions with: clonidine, verapamil
See: www.drugeruptiondata.com/drug/id/1282 Pregnancy category: C
See: www.drugeruptiondata.com/drug/id/917 Important contra-indications noted in the
pediatric patients
BENDROFLUME- BENZPHETAMINE Note: Cutaneous side effects of beta-receptor
blockers are clinically polymorphous. They
THIAZIDE See: www.drugeruptiondata.com/drug/id/959 apparently appear after several months of
continuous therapy.
BENZTHIAZIDE Skin
Cold extremities (2%)
BENZALKONIUM See: www.drugeruptiondata.com/drug/id/69 Dermatitis [3]
Diaphoresis (<2%)
Eczema (<2%)
BENZTROPINE Edema (<2%)
Erythema (<2%)
BENZNIDAZOLE * See: www.drugeruptiondata.com/drug/id/70 Lymphadenopathy (<2%)
Pruritus (<2%)
Indications: Chagas disease (trypanosomiasis) in Purpura (<2%)
pediatric patients aged 2–12 years Rash (<2%) [3]
Class: Antibiotic, nitroimidazole BENZYDAMINE Hair
Half-life: 13 hours
Clinically important, potentially hazardous See: www.drugeruptiondata.com/drug/id/1332 Alopecia (<2%)
interactions with: disulfiram Hypertrichosis (<2%)
Pregnancy category: N/A (Can cause fetal Mucosal
harm) BENZYL ALCOHOL Epistaxis (nosebleed) (<2%)
Important contra-indications noted in the Oral ulceration (<2%)
prescribing guidelines for: nursing mothers See: www.drugeruptiondata.com/drug/id/1721 Sialorrhea (<2%)
Note: Has the potential for genotoxicity and Xerostomia (<2%)
carcinogenicity. Cardiovascular
Skin
BEPOTASTINE Angina (<2%)
Arrhythmias (<2%)
Edema [4] See: www.drugeruptiondata.com/drug/id/1731 Atrioventricular block (<2%)
Hypersensitivity [3] Bradycardia (6–8%)
Pigmentation [2] Cardiac failure (<2%)
Pruritus [5] Chest pain (2–7%)
Rash [7] BEPRIDIL Flushing (<2%)
Stevens-Johnson syndrome [2] Hypertension (<2%)
Urticaria [2] See: www.drugeruptiondata.com/drug/id/71 Hypotension (<2%)
Litt’s Drug Eruption & Reaction Manual BEVACIZUMAB
Myocardial infarction (<2%) Oliguria (<2%) Diarrhea (2%)

Palpitation (2%) Peyronie’s disease (<2%) Nausea (2%)
Peripheral ischemia (<2%) Prostatitis (<2%) Endocrine/Metabolic
Central Nervous System Renal Hypokalemia (3%)
Ageusia (taste loss) (<2%) Proteinuria (<2%) Genitourinary
Amnesia (<2%) Renal function abnormal (<2%) Hematuria (2%)
Anorexia (<2%) Hematologic Urinary tract infection (3%)
Confusion (<2%) Anemia (<2%)
Dysgeusia (taste perversion) (<2%) Hematologic
Lymphocytosis (<2%) Bleeding (<2%) [2]
Emotional lability (<2%) Thrombocytopenia (<2%)
Fever (<2%) Thrombosis (<2%)
Hallucinations (<2%)
Headache (7–15%) Otic BEVACIZUMAB
Insomnia (<5%) Ear pain (<2%)
Pain (<2%) Hearing loss (<2%) Trade name: Avastin (Genentech)
Paresthesias (2%) Tinnitus (<2%) Indications: Colon cancer
Rigors (<2%) Ocular Class: Biologic, Monoclonal antibody, Vascular
Stupor (<2%) Abnormal vision (<2%) endothelial growth factor antagonist
Syncope (<2%) Blepharitis (<2%) Half-life: 20 days
Tremor (<2%) Cataract (<2%) Clinically important, potentially hazardous
Twitching (<2%) Conjunctivitis (<2%) interactions with: antineoplastics, irinotecan,
Vertigo (dizziness) (5–15%) Iritis (<2%) sorafenib, sunitinib
Neuromuscular/Skeletal Lacrimation (<2%) Pregnancy category: C
Arthralgia (3%) Ocular hemorrhage (<2%) Important contra-indications noted in the
Asthenia (fatigue) (3–10%) Scotoma (<2%) prescribing guidelines for: the elderly; nursing
Ataxia (<2%) Xerophthalmia (<2%) mothers; pediatric patients
Bone or joint pain (5%) Other Warning: GASTROINTESTINAL
Leg cramps (<2%) Allergic reactions (<2%) PERFORATIONS, SURGERY AND WOUND
Myalgia/Myopathy (3%) Dipsia (thirst) (<2%) HEALING COMPLICATIONS, and
Neck pain (<2%) HEMORRHAGE
Tendinitis (<2%)
Gastrointestinal/Hepatic BETHANECHOL Skin
Constipation (<2%) Acneform eruption [6]
Diarrhea (2%) See: www.drugeruptiondata.com/drug/id/74 Hand–foot syndrome [12]
Dyspepsia (4–5%) Necrosis [2]
Dysphagia (<2%) Rash [16]
Nausea (2–6%) Toxicity [9]
Vomiting (<2%)
BETRIXABAN * Ulcerations [3]
Wound complications [8]
Respiratory Trade name: Bevyxxa (Portola)
Bronchitis (<2%) Indications: Prophylaxis of venous Hair
Bronchospasm (<2%) thromboembolism in adult patients hospitalized Alopecia [5]
Cough (<2%) for an acute medical illness who are at risk for Mucosal
Dysphonia (<2%) thromboembolic complications Epistaxis (nosebleed) [5]
Dyspnea (2%) Class: Direct factor Xa inhibitor Mucosal inflammation [2]
Influenza (<2%) Half-life: 19–27 hours Mucositis [11]
Pharyngitis (2%) Clinically important, potentially hazardous Oral ulceration [2]
Pneumonia (<2%) interactions with: amiodarone, anticoagulants, Stomatitis [8]
Sinusitis (<2%) antiplatelet drugs and thrombolytics, Cardiovascular
Upper respiratory tract infection (3%) azithromycin, clarithromycin, ketoconazole, Cardiac failure [2]
Endocrine/Metabolic verapamil Cardiotoxicity [6]
Acidosis (<2%) Pregnancy category: N/A (Likely to increase Hypertension (23–67%) [79]
ALT increased (<2%) the risk of hemorrhage during pregnancy and Hypotension (7–15%)
Appetite increased (<2%) delivery) Thromboembolism (<21%) [14]
AST increased (<2%) Important contra-indications noted in the Venous thromboembolism [5]
Diabetes mellitus (<2%) prescribing guidelines for: nursing mothers;
pediatric patients Central Nervous System
Gynecomastia (<2%) Anorexia [14]
Hypercholesterolemia (<2%) Note: Contra-indicated in patients with active
pathological bleeding. Cerebral hemorrhage [5]
Hyperglycemia (<2%) Headache [6]
Hyperkalemia (<2%) Warning: SPINAL/EPIDURAL HEMATOMA
Intracranial hemorrhage [2]
Hyperuricemia (<2%) Leukoencephalopathy [19]
Hypokalemia (<2%) Mucosal Neurotoxicity [13]
Libido decreased (<2%) Epistaxis (nosebleed) (2%) Peripheral neuropathy [9]
Mastodynia (<2%) Cardiovascular Seizures [2]
Menstrual irregularities (<2%) Hypertension (2%)
Weight gain (<2%) Neuromuscular/Skeletal
Weight loss (<2%) Central Nervous System Arthralgia [2]
Headache (2%) Asthenia (fatigue) [35]
Genitourinary Osteonecrosis [5]
Cystitis (<2%) Gastrointestinal/Hepatic
Dysuria (<2%) Constipation (3%)
BEVACIZUMAB See all our books at www.crcpress.com
Gastrointestinal/Hepatic Pregnancy category: X

Abdominal pain [4] Important contra-indications noted in the BEZLOTOXUMAB
Colitis [3] prescribing guidelines for: nursing mothers;
Diarrhea [42] pediatric patients Trade name: Zinplava (Merck)
Gastrointestinal bleeding [5] Note: Retinoids can cause birth defects, and Indications: To reduce the recurrence of
Gastrointestinal fistula [2] women should avoid bexarotene when pregnant Clostridium difficile infection (CDI) in patients who
Gastrointestinal perforation [25] or trying to conceive. are receiving antibacterial treatment of CDI and
Hepatotoxicity [4] Warning: AVOID IN PREGNANCY are at high risk for CDI recurrence
Nausea [11] Class: C. difficile toxin inhibitor, Monoclonal
Vomiting [9] antibody
Skin Half-life: ~19 days
Respiratory Acneform eruption (<10%) Clinically important, potentially hazardous
Hemoptysis [4] Bacterial infection (<13%) interactions with: none known
Pulmonary embolism [4] Dermatitis [2] Pregnancy category: N/A (No data available)
Pulmonary toxicity [2] Erythema [2] Important contra-indications noted in the
Endocrine/Metabolic Exanthems (<10%) prescribing guidelines for: nursing mothers;
ALT increased [3] Exfoliative dermatitis (1028%) pediatric patients
Creatine phosphokinase increased [2] Necrosis [2]
Hyperglycemia [2] Nodular eruption (<10%)
Peripheral edema (13%) Cardiovascular
Hypokalemia [3] Cardiac failure (2%)
Hypomagnesemia [2] Pruritus (2030%) [5]
Rash (17%) [2] Central Nervous System
Renal Ulcerations (<10%) Fever (5%)
Proteinuria [32] Vesiculobullous eruption (<10%) Headache (4%)
Hematologic Xerosis (11%) [2] Gastrointestinal/Hepatic
Anemia [12] Hair Diarrhea [2]
Bleeding [9] Alopecia (411%) Nausea (7%) [2]
Febrile neutropenia [13]
Hemorrhage [13] Mucosal Local
Leukocytopenia [2] Cheilitis (<10%) Infusion-related reactions (10%)
Leukopenia [13] Gingivitis (<10%)
Lymphopenia [4] Mucositis [2]
Xerostomia (<10%)
Neutropenia [41] BICALUTAMIDE
Thrombocytopenia [22] Central Nervous System
Thrombosis [16] Chills (10%) Trade name: Casodex (AstraZeneca)
Thrombotic complications [3] Hyperesthesia (<10%) Indications: Metastatic prostatic carcinoma
Thrombotic microangiopathy [2] Neuromuscular/Skeletal Class: Androgen antagonist
Ocular Arthralgia [2] Half-life: up to 10 days
Hallucinations, visual [2] Asthenia (fatigue) [2] Clinically important, potentially hazardous
Intraocular pressure increased [3] Myalgia/Myopathy (<10%) [2] interactions with: CYP3A4 substrates
Iritis [2] Pregnancy category: X (not indicated for use in
Respiratory women)
Ocular adverse effects [2] Flu-like syndrome (413%)
Uveitis [2] Important contra-indications noted in the
Endocrine/Metabolic prescribing guidelines for: pediatric patients
Other Hypercholesterolemia [4]
Adverse effects [22] Hyperlipidemia [4]
Allergic reactions [3] Skin
Hypertriglyceridemia [6] Diaphoresis (6%)
Death [16] Hypothyroidism [6]
Hiccups [2] Edema (25%)
Mastodynia (<10%) Hot flashes (49%) [9]
Infection [9]
Hematologic Peripheral edema (8%)
Anemia [4] Pruritus (25%)
Leukopenia [4] Rash (6%)
BEXAROTENE Lymphopenia [2] Xerosis (25%)
Neutropenia [6] Hair
Trade name: Targretin (Eisai)
Indications: Cutaneous T-cell lymphoma, Other Alopecia (25%)
mycosis fungoides Adverse effects [2] Mucosal
Class: Antineoplastic, Retinoid Xerostomia (25%)
Half-life: 7 hours Central Nervous System
Clinically important, potentially hazardous BEZAFIBRATE Paresthesias (6%)
interactions with: acitretin, atorvastatin, beta-
carotene, carboplatin, conivaptan, See: www.drugeruptiondata.com/drug/id/1318 Neuromuscular/Skeletal
dexamethasone, dong quai, gemfibrozil, Asthenia (fatigue) [4]
grapefruit juice, isotretinoin, oral contraceptives, Myalgia/Myopathy (25%)
paclitaxel, saxagliptin, St John’s wort, tamoxifen, Gastrointestinal/Hepatic
tetracyclines, tretinoin, vitamin A Constipation [2]
Hepatotoxicity [4]
Endocrine/Metabolic
Gynecomastia (38%) [34]
Mastodynia (39%) [16]
Litt’s Drug Eruption & Reaction Manual BIVALIRUDIN
Local
Injection-site reactions (25%) BIPERIDEN BISOPROLOL
See: www.drugeruptiondata.com/drug/id/77 Trade names: Cardicor (Merck Serono), Concor
(Merck Serono), Emcor (Merck Serono), Zebeta
BIMATOPROST (Barr), Ziac (Barr)
Trade names: Latisse (Allergan), Lumigan BISACODYL Indications: Hypertension
Class: Beta adrenergic blocker, Beta blocker
(Allergan) Half-life: 912 hours
Indications: Reduction of elevated intraocular See: www.drugeruptiondata.com/drug/id/78
pressure in open-angle glaucoma or ocular interactions with: diltiazem, disopyramide,
hypertension, hypotrichosis of the eyelashes guanethidine, reserpine, rifampin, verapamil
Class: Prostaglandin analog BISMUTH Pregnancy category: C
Half-life: 45 minutes Important contra-indications noted in the
Clinically important, potentially hazardous Trade names: Helidac (Prometheus), Pepto- prescribing guidelines for: nursing mothers;
interactions with: none known Bismol (Procter & Gamble) pediatric patients
Pregnancy category: C Indications: As part of ‘triple therapy’ Note: Ziac is bisoprolol and hydrochlorothiazide.
Important contra-indications noted in the (antibiotics + bismuth) for eradication of H. Hydrochlorothiazide is a sulfonamide and can be
prescribing guidelines for: nursing mothers; pylori. Bismuth subgallate initiates clotting via absorbed systemically. Sulfonamides can produce
pediatric patients activation of factor XII, and is used for bleeding severe, possibly fatal, reactions such as toxic
during tonsillectomy and adenoidectomy. BIPP epidermal necrolysis and Stevens-Johnson
Skin impregnated ribbon gauze is used for packing syndrome.
Pigmentation [2] following ear surgery. Bismuth subsalicylate is in Contra-indicated in patients with cardiogenic
OTC products for gastrointestinal complaints and shock, overt cardiac failure, second or third
Hair peptic ulcer disease
Hirsutism (<5%) degree AV block, and marked sinus bradycardia.
Class: Disinfectant, Heavy metal
Hypertrichosis [2] Half-life: 2172 days
Central Nervous System Clinically important, potentially hazardous Skin
Headache (<5%) interactions with: aspirin, ciprofloxacin, Edema (3%)
demeclocycline, doxycycline, hypoglycemics, Peripheral edema (<10%)
Neuromuscular/Skeletal Rash (<10%)
Asthenia (fatigue) (<5%) lomefloxacin, lymecycline, methotrexate,
minocycline, tetracycline, warfarin Raynaud’s phenomenon (<10%)
Respiratory Pregnancy category: D (category C in first and Cardiovascular
Nasopharyngitis [2] second trimesters; category D in third trimester) Bradycardia [6]
Upper respiratory tract infection (10%) Hypotension [3]
Ocular Skin Central Nervous System
Asthenopia (<10%) Dermatitis [2] Headache [2]
Blepharitis (<10%) Hypersensitivity [2] Hyperesthesia (2%)
Cataract (<10%) Pigmentation [5] Vertigo (dizziness) [3]
Choroidal detachment [2] Pruritus (triple therapy) [2]
Conjunctival edema (<10%) Neuromuscular/Skeletal
Rash [4] Myalgia/Myopathy (<10%)
Conjunctival hemorrhage (<10%)
Conjunctival hyperemia (25–45%) [42] Mucosal Other
Conjunctivitis (<10%) Oral pigmentation [3] Adverse effects [4]
Deepening of upper lid sulcus [9] Stomatitis [4]
Eyelashes – hypertrichosis (>10%) [13] Tongue pigmentation (>10%) [3]
Xerostomia (triple therapy) (41%)
Eyelashes – pigmentation (<10%) [3]
Eyelid erythema (310%) [2] Central Nervous System
BIVALIRUDIN
Eyelid irritation (310%) Dysgeusia (taste perversion) (triple therapy) Trade name: Angiomax (The Medicines
Eyelid pain (310%) (46%) [9] Company)
Eyelid pigmentation (310%) [6] Encephalopathy [4] Indications: Angioplasty adjunct
Eyelid xerosis (310%) Pain (triple therapy) (10%) Class: Thrombin inhibitor
Eyes – adverse effects [2] Tremor [2] Half-life: 25 minutes
Foreign body sensation (<10%) Vertigo (dizziness) [2] Clinically important, potentially hazardous
Iris pigmentation (<10%) [4] Neuromuscular/Skeletal interactions with: anisindione, dicumarol,
Keratitis [2] Arthralgia [10] heparin, reteplase, streptokinase, tenecteplase,
Lacrimation (<10%) Asthenia (fatigue) [2] urokinase, warfarin
Macular edema [2] Pregnancy category: B
Ocular adverse effects [10] Gastrointestinal/Hepatic
Ocular burning (<10%) Diarrhea [5]
Ocular discharge (<10%) Nausea [4] Central Nervous System
Ocular hyperemia [4] Vomiting [2] Pain (15%)
Ocular itching (<10%) Other Neuromuscular/Skeletal
Ocular pain [2] Adverse effects (triple therapy) [52] Back pain (42%)
Ocular pigmentation (<3%) [5] Allergic reactions [2] Hematologic
Ocular pruritus (>10%) [5] Death [10] Bleeding [5]
Periorbital pigmentation (<10%) [3] Thrombosis [3]
Photophobia (<10%)
Punctate keratitis (<10%) [2] Local
Uveitis [3] Injection-site pain (8%)
BLEOMYCIN Over 100 updates per week on www.drugeruptiondata.com
Hyperglycemia (11%) [2]

BLEOMYCIN BLINATUMOMAB Hypoalbuminemia (4%)
Hypokalemia (23%) [5]
Synonyms: bleo; BLM Trade name: Blincyto (Amgen) Hypomagnesemia (12%)
Trade name: Blenoxane (Mead Johnson) Indications: Precursor B-cell acute Hypophosphatemia (6%)
Indications: Melanomas, sarcomas, lymphomas, lymphoblastic leukemia Weight gain (11%)
testicular carcinoma Class: Bispecific CD19-directed CD3 T-cell
Class: Antibiotic, anthracycline engager, Monoclonal antibody Hematologic
Half-life: 1.39 hours Half-life: 1.4 hours Anemia (18%) [5]
Clinically important, potentially hazardous Clinically important, potentially hazardous Febrile neutropenia (25%) [8]
interactions with: aldesleukin, brentuximab interactions with: none known Leukocytosis (2%)
vedotin Pregnancy category: C Leukopenia (9%) [5]
Pregnancy category: D Important contra-indications noted in the Lymphopenia [3]
Important contra-indications noted in the prescribing guidelines for: nursing mothers Neutropenia (16%) [4]
prescribing guidelines for: nursing mothers; Warning: CYTOKINE RELEASE SYNDROME Sepsis (7%) [3]
pediatric patients and NEUROLOGICAL TOXICITIES Thrombocytopenia (11%) [6]
Local
Skin Skin Catheter-related infection [2]
Acral erythema [2] Edema (5%) [4]
Acral necrosis [2] Peripheral edema (25%) [2]
Bullous dermatitis (<5%) Rash (21%) [2] BOCEPREVIR
Calcification [2] Tumor lysis syndrome (4%)
Erythema [6] Cardiovascular Trade name: Victrelis (Merck)
Exanthems [3] Chest pain (11%) Indications: Chronic hepatitis C
Flagellate dermatitis [8] Hypertension (8%) Class: CYP3A4 inhibitor, Direct-acting antiviral,
Flagellate erythema/pigmentation [44] Hypotension (11%) Hepatitis C virus NS3/4A protease inhibitor
Gangrene (digital) [3] Tachycardia (8%) Half-life: 3 hours
Hyperkeratosis (palms and soles) [2] Clinically important, potentially hazardous
Hypersensitivity (<10%) [5] Central Nervous System interactions with: alfuzosin, alprazolam,
Linear streaking [4] Aphasia (4%) [5] amiodarone, atorvastatin, bepridil, bosentan,
Lipodystrophy [2] Chills (15%) brigatinib, budesonide, buprenorphine,
Neutrophilic eccrine hidradenitis [2] Confusion (7%) [4] cabozantinib, carbamazepine, cisapride,
Pigmentation (~50%) [21] Cytokine release syndrome (11%) [12] clarithromycin, colchicine, copanlisib,
Pruritus (>5%) [7] Disorientation (3%) [3] cyclosporine, dasatinib, desipramine,
Raynaud’s phenomenon (>10%) [34] Encephalopathy (5%) [6] dexamethasone, digoxin, dihydroergotamine,
Scleroderma [16] Fever (62%) [9] drospirenone, efavirenz, ergonovine, ergotamine,
Stevens-Johnson syndrome [2] Headache (36%) [7] estradiol, felodipine, flecainide, flibanserin,
Toxicity [2] Insomnia (15%) fluticasone propionate, gefitinib, itraconazole,
Memory loss (2%) ketoconazole, lomitapide, lovastatin, methadone,
Hair Neurotoxicity [8]
Alopecia (~50%) [7] methylergonovine, midazolam, midostaurin,
Paresthesias (5%) [2] mifepristone, neratinib, nicardipine, nifedipine,
Nails Seizures (2%) [7] olaparib, pazopanib, phenobarbital, phenytoin,
Nail growth reduced [2] Somnolence (drowsiness) [2] pimozide, ponatinib, posaconazole, propafenone,
Nail loss [3] Speech disorder [3] quinidine, ribociclib, rifabutin, rifampin, ritonavir,
Onychodystrophy [2] Tremor (20%) [7] ruxolitinib, salmeterol, sildenafil, simvastatin,
Onycholysis [3] Vertigo (dizziness) (14%) [2] sirolimus, St John’s wort, tacrolimus, tadalafil,
Mucosal Neuromuscular/Skeletal trazodone, triazolam, vardenafil, vorapaxar,
Oral ulceration [2] Arthralgia (10%) voriconazole, warfarin
Stomatitis (>10%) [8] Asthenia (fatigue) (17%) [4] Pregnancy category: X (boceprevir is
Ataxia [2] pregnancy category B but must not be used in
Back pain (14%) [2] monotherapy)
Chills (>10%)
Bone or joint pain (11%) Important contra-indications noted in the
Neuromuscular/Skeletal Pain in extremities (12%) prescribing guidelines for: nursing mothers;
Digital necrosis [3] pediatric patients
Respiratory Note: Must be used in combination with PEG-
Abdominal pain (15%)
Pneumonitis [3] interferon and ribavirin (see separate entries)
Constipation (20%) [2]
Pulmonary fibrosis [3] Combination treatment is contra-indicated in
Diarrhea (20%) [3]
Pulmonary toxicity [7] pregnant women and men whose female partners
Hepatotoxicity [2]
are pregnant because of the risks for birth defects
Endocrine/Metabolic Nausea (25%) [4]
and fetal death associated with ribavirin, or in
SIADH [2] Vomiting (13%)
coadministration with drugs that are highly
Hematologic Respiratory dependent on CYP3A4/5 for clearance, or with
Hemolytic uremic syndrome [8] Cough (19%) [2] potent CYP3A4/5 inducers.
Local Dyspnea (15%)
Injection-site phlebitis (<10%) Pneumonia (9%) [4]
Skin
Other Endocrine/Metabolic Pruritus [3]
Adverse effects [2] ALT increased (12%) [2] Rash [3]
Allergic reactions [2] Appetite decreased (10%)
AST increased (11%)
Dysgeusia (taste perversion) [6]
GGT increased (6%) [2]
Hyperbilirubinemia (8%)
Litt’s Drug Eruption & Reaction Manual BOTULINUM TOXIN (A & B)
Gastrointestinal/Hepatic Neuromuscular/Skeletal elbasvir & grazoprevir, enzalutamide,

Hepatotoxicity [2] Arthralgia (17%) [2] erythromycin, fluconazole, fluvastatin,
Hematologic Asthenia (fatigue) (64%) [35] glibenclamide, glyburide, indinavir, itraconazole,
Anemia [24] Back pain (13%) ketoconazole, levonorgestrel, lopinavir, lovastatin,
Neutropenia [8] Bone or joint pain (14%) [2] neratinib, olaparib, oral contraceptives,
Thrombocytopenia [8] Cramps (11%) palbociclib, progestogens, reboxetine, rifampin,
Myalgia/Myopathy (12%) ritonavir, sildenafil, simvastatin, St John’s wort,
Other tacrolimus, tadalafil, telaprevir, tipranavir,
Adverse effects [6] Gastrointestinal/Hepatic
Abdominal distension [2] ulipristal, vardenafil, venetoclax, voriconazole,
Infection [2] warfarin
Abdominal pain [3]
Colitis [2] Pregnancy category: X
Constipation (41%) [7] Important contra-indications noted in the
BORTEZOMIB Diarrhea (52%) [22] prescribing guidelines for: nursing mothers;
Gastrointestinal disorder [2] pediatric patients
Trade name: Velcade (Millennium) Hepatotoxicity [4] Warning: RISKS OF HEPATOTOXICITY and
Indications: Multiple myeloma, mantle cell Nausea (55%) [10] TERATOGENICITY
lymphoma Pancreatitis [2]
Class: Biologic, Proteasome inhibitor Vomiting (33%) [4] Skin
Half-life: 915 hours Edema (8%) [2]
Clinically important, potentially hazardous Respiratory
Cough (20%) [2] Peripheral edema (8%) [5]
interactions with: conivaptan, darunavir, Pruritus (4%)
delavirdine, efavirenz, indinavir, strong CYP3A4 Dyspnea (21%) [6]
inhibitors or inducers, telithromycin, thalidomide, Nasopharyngitis (12%) Cardiovascular
voriconazole Pneumonia (12%) [8] Flushing (9%) [2]
Pregnancy category: D Pneumonitis [4] Central Nervous System
Important contra-indications noted in the Pulmonary toxicity [3] Headache [2]
prescribing guidelines for: nursing mothers; Upper respiratory tract infection (12%) [3] Syncope [2]
pediatric patients Endocrine/Metabolic Gastrointestinal/Hepatic
Note: Contra-indicated in patients with Appetite decreased (36%) Hepatotoxicity [17]
hypersensitivity to boron or mannitol. Dehydration (10%)
Hypocalcemia [2] Respiratory
Hypokalemia [3] Bronchitis [2]
Skin
Edema (23%) Serum creatinine increased [2] Endocrine/Metabolic
Erythema [2] Weight loss [2] AST increased [2]
Folliculitis [2] Renal Hematologic
Herpes zoster (12%) [13] Nephrotoxicity [2] Anemia [4]
Peripheral edema [5] Hematologic Other
Pruritus (11%) Anemia (29%) [16] Adverse effects [7]
Purpura [2] Febrile neutropenia [5]
Rash (18%) [9] Hemotoxicity [5]
Toxicity [4]
Leukopenia [8]
Lymphopenia [11]
BOSUTINIB
Tumor lysis syndrome [2] Myelosuppression [2]
Vasculitis [4] See: www.drugeruptiondata.com/drug/id/3037
Neutropenia (17%) [35]
Mucosal Sepsis [4]
Mucositis [2] Thrombocytopenia (36%) [51]
Cardiovascular Local
BOTULINUM TOXIN
Arrhythmias [2] Infusion-related reactions [2] (A & B)
Cardiac failure [3] Injection-site irritation (5%)
Cardiotoxicity [4] Injection-site reactions [4] Trade names: Azzalure (Galderma), Bocouture
Congestive heart failure [3] Other (Merz), Botox (Allergan), Dysport (Ipsen),
Hypertension [3] Adverse effects [13] Myobloc (Solstice), Neurobloc (Eisai), Vistabel
Hypotension (13%) [4] Death [6] (Allergan), Xeomin (Merz)
QT prolongation [2] Infection [11] Indications: Blepharospasm, hemifacial spasm,
Central Nervous System spasmodic torticollis, sialorrhea, hyperhidrosis,
Anxiety (10%) strabismus, oromandibular dystonia, cervical
Dysesthesia (23%) dystonia, spasmodic dysphonia, chronic migraine,
Dysgeusia (taste perversion) (13%)
BOSENTAN urinary incontinence in people with neurologic
Encephalopathy [3] conditions such as spinal cord injury and multiple
Trade name: Tracleer (Actelion) sclerosis who have overactivity of the bladder,
Fever (34%) [7] Indications: Pulmonary arterial hypertension
Guillain–Barré syndrome [2] cosmetic application for wrinkles
Class: Antihypertensive, Endothelin receptor Class: Acetylcholine inhibitor, Neuromuscular
Headache [3] (ETR) antagonist, Vasodilator
Hypoesthesia [2] blocker, Ophthalmic agent, toxin
Half-life: ~5 hours Half-life: 36 months
Insomnia (20%) [2] Clinically important, potentially hazardous
Neurotoxicity [26] Clinically important, potentially hazardous
interactions with: amiodarone, amprenavir, interactions with: aminoglycosides,
Pain [2] astemizole, atazanavir, atorvastatin, boceprevir,
Paresthesias (22%) [3] anticholinergics, fesoterodine, tiotropium,
cobicistat/elvitegravir/emtricitabine/tenofovir trospium
Peripheral neuropathy (39%) [58] alafenamide, cobicistat/elvitegravir/emtricitabine/
Vertigo (dizziness) (17%) tenofovir disoproxil, cyclosporine, diltiazem,
BOTULINUM TOXIN (A & B) See all our books at www.crcpress.com
Pregnancy category: C Diplopia [10] Gastrointestinal/Hepatic

Important contra-indications noted in the Eyelid edema [4] Abdominal pain (9–25%)
prescribing guidelines for: nursing mothers; Ocular adverse effects [2] Constipation (19%)
pediatric patients Ptosis (1420%) [24] Diarrhea (36%) [3]
Note: Distant spread of toxin effect - Xerophthalmia (6%) [2] Nausea (42%) [4]
postmarketing reports indicate that all botulinum Local Vomiting (22%)
toxin products may spread from the area of Injection-site bruising [4] Respiratory
injection to produce symptoms consistent with Injection-site ecchymoses [2] Cough (17–25%)
botulinum toxin effects. These may include Injection-site edema [8] Dyspnea (13–19%)
asthenia, generalized muscle weakness, diplopia, Injection-site erythema [3] Pulmonary toxicity [2]
ptosis, dysphagia, dysphonia, dysarthria, urinary Injection-site pain (210%) [20] Upper respiratory tract infection (12–47%)
incontinence and breathing diffculties. These Injection-site paralysis [2]
symptoms have been reported hours to weeks Endocrine/Metabolic
Injection-site reactions [6] Appetite decreased (16%)
after injection.
An antitoxin is available in the event of overdose Other Weight loss (6–12%)
or misinjection. Adverse effects [18] Hematologic
Warning: DISTANT SPREAD OF TOXIN Death [4] Anemia (33–52%)
EFFECT Infection (1319%) Neutropenia (55%) [6]
Side effects [3] Thrombocytopenia (16–28%)
Skin Other
Anaphylactoid reactions/Anaphylaxis [4] Adverse effects [2]
Ecchymoses [4] BRENTUXIMAB
Erythema [2]
Granulomas [2]
VEDOTIN
Hematoma [2]
BRETYLIUM
Trade name: Adcetris (Seattle Genetics)
Peripheral edema (<10%)
Indications: Hodgkin’s lymphoma, systemic See: www.drugeruptiondata.com/drug/id/81
Pruritus (<10%)
anaplastic large cell lymphoma
Purpura (<10%)
Class: Antibody drug conjugate (ADC), CD30-
Mucosal
Epistaxis (nosebleed) [2]
directed antibody-drug conjugate, Monoclonal
antibody
BREXPIPRAZOLE
Stomatitis (<10%) Half-life: 4–6 days Trade name: Rexulti (Otsuka)
Xerostomia (334%) [13] Clinically important, potentially hazardous Indications: Schizophrenia, major depressive
Central Nervous System interactions with: bleomycin, efavirenz, disorder (with antidepressants)
Dysgeusia (taste perversion) (<10%) ketoconazole, rifampin, strong CYP3A4 inhibitors Class: Antipsychotic
Gait instability [2] Pregnancy category: D Half-life: 86–91 hours
Headache [7] Important contra-indications noted in the Clinically important, potentially hazardous
Hyperesthesia (<10%) prescribing guidelines for: the elderly; nursing interactions with: strong or moderate CYP2D6
Neurotoxicity [3] mothers; pediatric patients inhibitors, strong or moderate CYP3A4 inducers
Pain (613%) [4] Warning: PROGRESSIVE MULTIFOCAL or inhibitors
Seizures [2] LEUKOENCEPHALOPATHY Pregnancy category: N/A (Neonatal risk in
Tremor (<10%) third trimester exposure)
Vertigo (dizziness) [2] Skin Important contra-indications noted in the
Neuromuscular/Skeletal Diaphoresis (12%) prescribing guidelines for: the elderly; nursing
Arthralgia (<7%) Lymphadenopathy (11%) mothers; pediatric patients
Asthenia (fatigue) [16] Peripheral edema (4–16%) Warning: INCREASED MORTALITY IN
Myasthenia gravis [2] Pruritus (19%) ELDERLY PATIENTS WITH DEMENTIA-
Neck pain [2] Rash (31%) RELATED PSYCHOSIS
Xerosis (10%) SUICIDAL THOUGHTS AND BEHAVIORS
Constipation [2] Hair
Diarrhea [3] Alopecia (14%) Central Nervous System
Dysphagia [16] Central Nervous System Agitation [3]
Anxiety (11%) Akathisia (6–9%) [12]
Respiratory
Chills (13%) Anxiety (3%) [2]
Dysphonia [2]
Fever (29–38%) [3] Headache (7%) [6]
Dyspnea [2]
Headache (19%) Insomnia [4]
Flu-like syndrome (210%) [8]
Insomnia (16%) Restlessness (3%)
Nasopharyngitis [2]
Neurotoxicity [2] Sedation (2%) [2]
Pain (7–28%) Somnolence (drowsiness) (5%) [4]
Genitourinary Peripheral neuropathy (68%) [10] Tremor (3–4%)
Hematuria [4] Vertigo (dizziness) (11–16%) Vertigo (dizziness) (3%)
Urinary incontinence [3]
Urinary retention [12] Neuromuscular/Skeletal Neuromuscular/Skeletal
Arthralgia (9–19%) Asthenia (fatigue) (3%) [2]
Urinary tract infection [15]
Vulvovaginal candidiasis (<10%) Asthenia (fatigue) (41–49%) [4] Gastrointestinal/Hepatic
Back pain (14%) Constipation (2%)
Otic Muscle spasm (10%) Diarrhea (3%) [2]
Tinnitus (<10%) Myalgia/Myopathy (17%) Dyspepsia (3%)
Ocular Pain in extremities (10%) Nausea [4]
Blepharoptosis [2]
Conjunctivitis [2]
Litt’s Drug Eruption & Reaction Manual BRINZOLAMIDE
Respiratory Appetite decreased (15–22%) Ocular pruritus (5–20%) [5]

Nasopharyngitis (4%) AST increased (38–65%) Ocular stinging (<10%) [6]
Endocrine/Metabolic Creatine phosphokinase increased (27–48%) Periocular dermatitis [2]
Appetite increased (3%) Hyperglycemia (38–49%) Uveitis [11]
Creatine phosphokinase increased (2%) Hypophosphatemia (15–23%) Vision blurred [T] [3]
Weight gain (4–7%) [13] Hematologic Visual disturbances (5–20%)
Weight loss (10%) Anemia (23–40%) Xerophthalmia [3]
Hematologic Hyperlipasemia (21–45%) Other
Hemotoxicity (2%) Lymphopenia (19–27%) Adverse effects [2]
Prothrombin time increased (20–22%) Allergic reactions [2]
Ocular
Visual disturbances (7–10%)
BRIGATINIB * BRINZOLAMIDE
Trade name: Alunbrig (Ariad)
Indications: Anaplastic lymphoma kinase- BRIMONIDINE Trade name: Azopt (Alcon)
Indications: Open-angle glaucoma, ocular
positive metastatic non-small cell lung cancer in
patients who have progressed on, or are Trade names: Alphagan P (Allergan), Mirvaso hypertension
intolerant to, crizotinib (Galderma) Class: Carbonic anhydrase inhibitor, Diuretic
Class: Tyrosine kinase inhibitor Indications: Open-angle glaucoma, ocular Half-life: 111 days
Half-life: 25 hours hypertension, topical application for rosacea Clinically important, potentially hazardous
Clinically important, potentially hazardous Class: Adrenergic alpha2-receptor agonist interactions with: conivaptan, darunavir,
interactions with: boceprevir, carbamazepine, Half-life: 12 hours delavirdine, indinavir, salicylates, telithromycin,
clarithromycin, cobicistat, conivaptan, CYP3A Clinically important, potentially hazardous voriconazole
substrates and strong CYP3A inducers or interactions with: amitriptyline, MAO Pregnancy category: C
inhibitors, grapefruit juice, hormonal inhibitors, tricyclic antidepressants Important contra-indications noted in the
contraceptives, indinavir, itraconazole, Pregnancy category: B prescribing guidelines for: nursing mothers
ketoconazole, lopinavir, nelfinavir, phenytoin, Important contra-indications noted in the Note: Brinzolamide is a sulfonamide and can be
posaconazole, rifampin, ritonavir, saquinavir, St prescribing guidelines for: nursing mothers; absorbed systemically. Sulfonamides can produce
John’s wort, voriconazole pediatric patients severe, possibly fatal, reactions such as toxic
Pregnancy category: N/A (May cause fetal Note: [T] = Topical. epidermal necrolysis and Stevens-Johnson
toxicity based on findings in animal studies) syndrome.
Important contra-indications noted in the Skin
prescribing guidelines for: nursing mothers; Burning [T] (2%) [4] Skin
pediatric patients Contact dermatitis [T] [2] Dermatitis (<5%)
Dermatitis [2] Mucosal
Skin Erythema [T] (4%) [7] Xerostomia [4]
Rash (15–24%) Hypersensitivity [3] Central Nervous System
Cardiovascular Irritation [3] Dysgeusia (taste perversion) (510%) [14]
Bradycardia (6–8%) Pruritus [4] Headache (<5%)
Hypertension (11–21%) Rosacea [2]
Xerosis [2] Neuromuscular/Skeletal
Central Nervous System Asthenia (fatigue) [3]
Fever (6–14%) Mucosal
Xerostomia (5–20%) [12] Respiratory
Headache (27–28%) [2] Rhinitis (<5%)
Insomnia (7–11%) Cardiovascular
Peripheral neuropathy (13%) Flushing [T] (3%) [3] Endocrine/Metabolic
Hypertension (5–20%) Acidosis [2]
Arthralgia (14%) Central Nervous System Ocular
Asthenia (fatigue) (29–36%) Dysgeusia (taste perversion) (<10%) [4] Blepharitis (<5%)
Back pain (10–15%) Somnolence (drowsiness) [2] Conjunctival hyperemia [8]
Muscle spasm (12–17%) Conjunctivitis [3]
Neuromuscular/Skeletal Corneal abnormalities [3]
Myalgia/Myopathy (9–15%) Asthenia (fatigue) [4]
Pain in extremities (4–11%) Foreign body sensation (<5%)
Respiratory Lacrimation [3]
Gastrointestinal/Hepatic Upper respiratory tract infection (<10%) Ocular adverse effects [3]
Abdominal pain (10–17%) Ocular allergy [2]
Constipation (15–19%) Ocular
Blepharitis (<10%) [2] Ocular burning [4]
Diarrhea (19–38%) [3] Ocular discharge (<5%)
Nausea (33–40%) [2] Conjunctival hyperemia (5–20%) [5]
Conjunctivitis (5–20%) [7] Ocular hyperemia [5]
Vomiting (23–24%) Ocular itching [6]
Eyelid crusting (<10%)
Respiratory Eyelid edema (<10%) Ocular keratitis (<5%)
Cough (18–34%) [2] Eyelid erythema (<10%) Ocular pain (<5%) [6]
Dyspnea (21–27%) [3] Intraocular pressure increased [2] Ocular pruritus (<5%) [3]
Hypoxia (<3%) [2] Ocular adverse effects [4] Ocular stinging [4]
Pneumonia (5–10%) [2] Ocular allergy (4%) [8] Vision blurred (510%) [15]
Pneumonitis (4–9%) Ocular burning (<10%) [7] Xerophthalmia (<5%) [5]
Pulmonary toxicity [2] Ocular hyperemia [4] Other
Endocrine/Metabolic Ocular itching [2] Adverse effects [2]
ALT increased (34–40%) Ocular pain [3]
BRIVARACETAM Over 100 updates per week on www.drugeruptiondata.com
Warning: SUICIDAL IDEATION AND Hair

BRIVARACETAM BEHAVIOR Alopecia [2]
Trade name: Briviact (UCB) Mucosal
Indications: Epilepsy adjunct therapy Skin Nasal congestion (3–4%)
Class: Anticonvulsant, Antiepileptic Candidiasis [2] Xerostomia (410%) [3]
Half-life: 9 hours Contact dermatitis [2] Cardiovascular
Clinically important, potentially hazardous Folliculitis [2] Cardiotoxicity [2]
interactions with: carbamazepine, phenytoin, Mucosal Coronary spasm [2]
rifampin Oropharyngeal pain (2%) Erythromelalgia [4]
Pregnancy category: C Central Nervous System Flushing [2]
Important contra-indications noted in the Headache (4%) [8] Orthostatic hypotension (6%)
prescribing guidelines for: the elderly; nursing Suicidal ideation [4] Postural hypotension (6%)
mothers; pediatric patients Central Nervous System
Arthralgia (5%) [8] Anorexia (4%)
Central Nervous System Asthenia (fatigue) (3%) Hallucinations [4]
Aggression [2] Back pain [2] Headache (<19%) [3]
Balance disorder (3%) Myalgia/Myopathy (2%) Seizures (in postpartum patients) [3]
Depression [2] Somnolence (drowsiness) (3%)
Dysgeusia (taste perversion) (<3%) Gastrointestinal/Hepatic Syncope (<2%)
Euphoria (<3%) Diarrhea (2%) [4] Vertigo (dizziness) (17%)
Headache [11] Nausea (2%) [2]
Impaired concentration [2] Respiratory Asthenia (fatigue) (3–7%)
Insomnia [2] Nasopharyngitis [12]
Irritability (3%) [7] Upper respiratory tract infection [14] Gastrointestinal/Hepatic
Neurotoxicity (13%) Abdominal pain (4%)
Hematologic Constipation (3–14%) [2]
Sedation (16%) Neutropenia [4]
Seizures [3] Diarrhea (3%)
Somnolence (drowsiness) (16%) [22] Local Dyspepsia (4%)
Vertigo (dizziness) (12%) [21] Injection-site bleeding (<2%) Gastrointestinal bleeding (<2%)
Injection-site bruising (<2%) Nausea (18–49%) [7]
Neuromuscular/Skeletal Injection-site erythema (<2%) [4] Vomiting (2–5%) [4]
Asthenia (fatigue) (9%) [15] Injection-site pain (<2%)
Back pain [2] Respiratory
Injection-site pruritus (<2%) Pleural effusion [2]
Gastrointestinal/Hepatic Injection-site reactions (2%) Pulmonary fibrosis [2]
Constipation (2%) Other
Nausea (5%) [5] Other
Infection (25%) Adverse effects [2]
Vomiting (5%) [3]
Respiratory
Nasopharyngitis [6] BROMFENAC
Genitourinary
BROMPHENIRAMINE
Urinary tract infection [2] See: www.drugeruptiondata.com/drug/id/1181 See: www.drugeruptiondata.com/drug/id/84
Hematologic
Leukopenia (2%)
Local BROMOCRIPTINE BUCILLAMINE
Infusion-site pain (<3%)
Trade name: Parlodel (Novartis) See: www.drugeruptiondata.com/drug/id/1079
Other Indications: Amenorrhea, Parkinsonism,
Adverse effects [4] infertility, acromegaly
Class: Dopamine receptor agonist
Half-life: initial: 68 hours; terminal: 50 hours BUCLIZINE
BRODALUMAB * Clinically important, potentially hazardous
interactions with: alcohol, antipsychotics,
Trade name: Siliq (Valeant) azithromycin, domperidone, erythromycin,
Indications: Moderate to severe plaque psoriasis isometheptene, lanreotide, levomepromazine,
Class: Interleukin-17A (IL-17A) antagonist, macrolides, memantine, methyldopa, BUDESONIDE
Monoclonal antibody metoclopramide, octreotide, pasireotide,
Half-life: N/A pseudoephedrine, risperidone, Trade names: Pulmicort Turbuhaler
Clinically important, potentially hazardous sympathomimetics, zuclopenthixol (AstraZeneca), Rhinocort (AstraZeneca),
interactions with: CYP450 substrates, live Pregnancy category: N/A (Contra-indicated in Symbicort (AstraZeneca)
vaccines women who become pregnant or in the Indications: Asthma, rhinitis
Pregnancy category: N/A (Insufficient evidence postpartum period) Class: Corticosteroid, inhaled
to inform drug-associated risk) Important contra-indications noted in the Half-life: N/A
Important contra-indications noted in the prescribing guidelines for: nursing mothers; Clinically important, potentially hazardous
prescribing guidelines for: nursing mothers; pediatric patients interactions with: boceprevir, efavirenz,
pediatric patients itraconazole, ketoconazole, live vaccines, oral
Note: Contra-indicated in patients with Crohn’s Skin contraceptives, telaprevir
disease. Livedo reticularis [3]
Raynaud’s phenomenon (<10%) [8]
Scleroderma [2]
Litt’s Drug Eruption & Reaction Manual BUPROPION
Pregnancy category: C Warning: ABUSE POTENTIAL, LIFE-

Important contra-indications noted in the THREATENING RESPIRATORY DEPRESSION, BUPROPION
prescribing guidelines for: nursing mothers; and ACCIDENTAL EXPOSURE
pediatric patients Probuphine: IMPLANT MIGRATION, PROTRU- Trade names: Wellbutrin (GSK), Zyban (GSK)
Note: Symbicort is budesonide and formoterol. Indications: Depression, aid to smoking
SION, EXPULSION, and NERVE DAMAGE
cessation
ASSOCIATED WITH INSERTION and Class: Antidepressant, Dopamine reuptake
Skin REMOVAL inhibitor
Acneform eruption [2] Half-life: 14 hours
Dermatitis [8] Clinically important, potentially hazardous
Exanthems [2] Skin
Abscess (2%) interactions with: amitriptyline, citalopram,
Pruritus [2] cobicistat/elvitegravir/emtricitabine/tenofovir
Rash [2] Dermatitis [2]
Diaphoresis (12–14%) alafenamide, cobicistat/elvitegravir/emtricitabine/
Mucosal Erythema [4] tenofovir disoproxil, cyclosporine,
Oral candidiasis [2] Hyperhidrosis [4] deutetrabenazine, efavirenz, eluxadoline,
Respiratory Pruritus [11] erythromycin, escitalopram, isocarboxazid,
Asthma (exacerbation) [4] levodopa, linezolid, lopinavir, lorcaserin,
Mucosal methylphenidate, mifepristone, phenelzine,
Cough [2] Xerostomia [3] ritonavir, tranylcypromine, trimipramine,
Endocrine/Metabolic Cardiovascular vortioxetine
Adrenal insufficiency [3] Bradycardia [3] Pregnancy category: C
Cushing’s syndrome [2] Hypotension [4] Important contra-indications noted in the
Ocular Pulmonary edema [2] prescribing guidelines for: nursing mothers;
Cataract [2] QT prolongation [2] pediatric patients
Other Vasodilation (9%) Warning: NEUROPSYCHIATRIC REACTIONS;
Adverse effects [11] Central Nervous System AND SUICIDAL THOUGHTS AND BEHAVIORS
Allergic reactions [3] Anxiety (12%)
Infection [2] Chills (6–8%) Skin
Systemic reactions [2] Depression (11%) Acneform eruption (<10%)
Fever (3%) AGEP [3]
Headache (30–36%) [6] Anaphylactoid reactions/Anaphylaxis [2]
Insomnia (14–25%) Angioedema [3]
BUMETANIDE Nervousness (6%) Diaphoresis (5%) [4]
See: www.drugeruptiondata.com/drug/id/86 Neurotoxicity [2] Erythema multiforme [4]
Pain (22–24%) Exanthems [2]
Seizures [3] Hypersensitivity [6]
Somnolence (drowsiness) (5%) [4] Lupus erythematosus [2]
BUPIVACAINE Vertigo (dizziness) (4%) [14] Peripheral edema [2]
Neuromuscular/Skeletal Pruritus (4%) [3]
See: www.drugeruptiondata.com/drug/id/1192 Psoriasis [2]
Back pain (4–14%) Rash (4%) [3]
Myalgia/Myopathy [2] Serum sickness [3]
BUPRENORPHINE Gastrointestinal/Hepatic
Serum sickness-like reaction [9]
Stevens-Johnson syndrome [2]
Trade names: Probuphine (Braeburn), Suboxone Abdominal pain (11%) [2] Thrombocytopenic purpura [2]
(Reckitt Benckiser), Subutex (Reckitt Benckiser), Constipation (11–12%) [12] Urticaria [9]
Transtec (Napp) Diarrhea (4–5%) [2] Xerosis (<10%)
Indications: Opioid dependence, moderate to Dyspepsia (3%)
Hepatotoxicity [6] Hair
severe pain Hirsutism (<10%)
Class: Analgesic, Mixed opioid agonist/antagonist, Nausea (10–15%) [15]
Narcotic Vomiting (5–8%) [12] Mucosal
Half-life: 37 hours Respiratory Tongue edema [2]
Clinically important, potentially hazardous Cough (4%) Xerostomia (<64%) [18]
interactions with: antihistamines, atazanavir, Flu-like syndrome (6%) Cardiovascular
azole antifungals, benzodiazepines, boceprevir, Pharyngitis (4%) Arrhythmias [2]
carbamazepine, cimetidine, cobicistat/elvitegravir/ Respiratory depression [3] Flushing (4%)
emtricitabine/tenofovir alafenamide, cobicistat/ Rhinitis (5–11%) Hypertension [2]
elvitegravir/emtricitabine/tenofovir disoproxil, Ocular Myocardial ischemia [2]
delavirdine, diazepam, efavirenz, erythromycin, Lacrimation (5%) Tachycardia [3]
HIV protease inhibitors, hydrocodone, Central Nervous System
hydromorphone, ketoconazole, ketorolac, Local
Application-site reactions [3] Agitation [4]
linezolid, macrolide antibiotics, morphine, Anxiety [4]
neuroleptics, oxymorphone, phenobarbital, Other Delirium [2]
phenytoin, rifampin, ritonavir, tapentadol, Adverse effects [4] Depression [3]
tipranavir Death [9] Dysgeusia (taste perversion) (4%)
Pregnancy category: C Infection (6–20%) Hallucinations [6]
Important contra-indications noted in the Headache [5]
prescribing guidelines for: nursing mothers; Insomnia [7]
pediatric patients Nightmares [2]
Note: Suboxone contains naloxone; Probuphine Paresthesias (2%)
is an implant for subdermal administration.
BUPROPION See all our books at www.crcpress.com
Parkinsonism [2] Exanthems [2]

Psychosis [6] BUSPIRONE Pigmentation (’busulfan tan’) (<10%) [13]
Seizures [40] Urticaria (>10%) [5]
Serotonin syndrome [2] Trade name: BuSpar (Bristol-Myers Squibb) Vasculitis [3]
Sleep related disorder [2] Indications: Anxiety
Class: Anxiolytic, Serotonin antagonist Hair
Somnolence (drowsiness) [4] Alopecia (>10%) [7]
Suicidal ideation [5] Half-life: 23 hours
Tremor (>10%) [7] Clinically important, potentially hazardous Mucosal
Twitching (2%) interactions with: citalopram, cobicistat/ Mucositis [4]
Vertigo (dizziness) [5] elvitegravir/emtricitabine/tenofovir alafenamide, Oral mucositis [2]
cobicistat/elvitegravir/emtricitabine/tenofovir Stomatitis [2]
Neuromuscular/Skeletal disoproxil, grapefruit juice, itraconazole, linezolid,
Arthralgia [3] Central Nervous System
nefazodone, paclitaxel, rifapentine, ritonavir, St Neurotoxicity [3]
Asthenia (fatigue) [3] John’s wort, telithromycin, vilazodone,
Dystonia [3] Seizures [3]
voriconazole
Myalgia/Myopathy (6%) [2] Pregnancy category: B Gastrointestinal/Hepatic
Rhabdomyolysis [3] Hepatotoxicity [4]
Gastrointestinal/Hepatic Hair Respiratory
Constipation [4] Alopecia [2] Pulmonary toxicity [3]
Hepatotoxicity [2] Endocrine/Metabolic
Nausea [13] Mucosal
Xerostomia (3%) Gynecomastia [3]
Vomiting [5] Porphyria cutanea tarda [2]
Respiratory Central Nervous System
Serotonin syndrome [4] Hematologic
Upper respiratory tract infection [2] Febrile neutropenia [3]
Genitourinary Other
Priapism [2]
Ocular
BUSULFAN Death [4]
Infection [3]
Hallucinations, visual [3] Trade name: Myleran (GSK)
Other Indications: Chronic myelogenous leukemia,
Adverse effects [2] bone marrow disorders BUTABARBITAL
Congenital malformations [2] Class: Alkylating agent
Death [5] Half-life: 3.4 hours (after first dose) See: www.drugeruptiondata.com/drug/id/90
interactions with: acetaminophen, aldesleukin,
BUSERELIN itraconazole, metronidazole, voriconazole
BUTALBITAL
See: www.drugeruptiondata.com/drug/id/1326 Warning: LEUKEMOGENESIS and See: www.drugeruptiondata.com/drug/id/91
PANCYTOPENIA
Skin BUTORPHANOL
Erythema (macular) (>10%)
Erythema multiforme [5] See: www.drugeruptiondata.com/drug/id/92
Erythema nodosum [3]
Litt’s Drug Eruption & Reaction Manual CALCIFEDIOL
Respiratory
C1-ESTERASE CABOZANTINIB Cough (18%)
Dysphonia (20%)
INHIBITOR Trade names: Carbometyx (Exelixis), Cometriq Dyspnea (19%)
(Exelixis) Pulmonary embolism [2]
See: www.drugeruptiondata.com/drug/id/1352 Indications: Metastatic medullary thyroid cancer
(Cometriq), advanced renal cell carcinoma Endocrine/Metabolic
(Cabometyx) ALP increased (52%)
CABAZITAXEL Class: Tyrosine kinase inhibitor
Appetite decreased (46%) [4]
Half-life: 55 hours (Cometriq); 99 hours
See: www.drugeruptiondata.com/drug/id/1701 (Cabometyx) AST increased (86%) [2]
Clinically important, potentially hazardous Dehydration (7%)
interactions with: atazanavir, boceprevir, GGT increased (27%)
carbamazepine, clarithromycin, conivaptan, Hypoalbuminemia (36%)
CABERGOLINE grapefruit juice, indinavir, itraconazole, Hypocalcemia (52%)
ketoconazole, lopinavir, nefazodone, nelfinavir, Hypokalemia (18%)
Trade name: Dostinex (Pfizer) Hypomagnesemia (19%)
phenobarbital, phenytoin, posaconazole, rifabutin,
Indications: Hyperprolactinemia, Parkinsonism Hyponatremia (10%)
rifampin, rifapentine, ritonavir, saquinavir, St
Class: Dopamine receptor agonist Hypophosphatemia (28%)
John’s wort, telithromycin, voriconazole
Half-life: 6369 hours Serum creatinine increased (58%)
Clinically important, potentially hazardous Weight loss (48%) [7]
interactions with: azithromycin,
levomepromazine, risperidone, zuclopenthixol
prescribing guidelines for: the elderly; nursing Renal
mothers; pediatric patients Proteinuria (2%)
Warning: PERFORATIONS AND FISTULAS, and Hematologic
HEMORRHAGE Anemia [2]
mothers; pediatric patients Lymphopenia (53%)
Skin Neutropenia (35%) [2]
Erythema (11%) Thrombocytopenia (35%) [2]
Skin
Hand–foot syndrome (50%) [16] Thrombosis [2]
Edema [2]
Hyperkeratosis (7%) Other
Hot flashes (3%)
Jaundice (25%) Adverse effects [4]
Mucosal Rash (19%)
Xerostomia (2%) Death (6%) [5]
Toxicity [2]
Cardiovascular Xerosis (19%)
Cardiac failure [2] Hair
Hypotension [5] Alopecia (16%)
CALCIFEDIOL
Myocardial toxicity [3] Hair changes (34%) Synonym: calcidiol
Pericarditis [4] Hair pigmentation (34%) [2] Trade name: Rayaldee (Opko)
Valve regurgitation [2]
Valvulopathy [9]
Mucosal Indications: Hyperparathyroidism in stage 3 or 4
Mucosal inflammation [2] chronic kidney disease
Central Nervous System Stomatitis (51%) Class: Vitamin D analog
Dyskinesia [2] Half-life: 11 days
Headache (26%) [6]
Cardiovascular
Chest pain (9%) Clinically important, potentially hazardous
Mania [3] interactions with: anticonvulsants, atazanavir,
Hypertension (33%) [13]
Neurotoxicity [3] cholestyramine, clarithromycin, indinavir,
Hypotension (7%)
Paresthesias (5%) [2] itraconazole, ketoconazole, nefazodone,
Psychosis [3] Central Nervous System nelfinavir, phenobarbital, ritonavir, saquinavir,
Somnolence (drowsiness) (<5%) Anorexia [2] telithromycin, thiazides, voriconazole
Vertigo (dizziness) (15–17%) [6] Anxiety (9%) Pregnancy category: C
Dysgeusia (taste perversion) (34%) Important contra-indications noted in the
Headache (18%) prescribing guidelines for: nursing mothers;
Paresthesias (7%) pediatric patients
Gastrointestinal/Hepatic Peripheral neuropathy (5%)
Abdominal pain (5%) Vertigo (dizziness) (14%)
Constipation (7–10%) Skin
Nausea (28%) [3]
Neuromuscular/Skeletal Hematoma (2%)
Arthralgia (14%)
Endocrine/Metabolic Asthenia (fatigue) (21–41%) [17] Cardiovascular
Mastodynia (2%) Muscle spasm (12%) Congestive heart failure (4%)
Pain in extremities (14%) Neuromuscular/Skeletal
Gastrointestinal/Hepatic Arthralgia (2%)
Abdominal pain (27%) Gastrointestinal/Hepatic
Constipation (27%) [2] Constipation (3%)
Diarrhea (63%) [15] Respiratory
Dyspepsia (11%) Bronchitis (3%)
Dysphagia (13%) Cough (4%)
Gastrointestinal perforation (3%) Dyspnea (4%)
Hemorrhoids (9%) Nasopharyngitis (5%)
Nausea (43%) [7]
Vomiting (24%) [4] Endocrine/Metabolic
Hyperkalemia (3%)
CALCIFEDIOL Over 100 updates per week on www.drugeruptiondata.com
Hyperuricemia (2%) Polyuria [2]

Serum creatinine increased (5%) CALCIUM Urinary frequency (5%) [6]
Urinary tract infection (4–6%) [20]
Hematologic HYDROXYLAPATITE Vulvovaginal pruritus (2–3%) [2]
Anemia (5%)
Trade name: Radiesse (Merz) Renal
Indications: Correction of facial wrinkles and Nephrotoxicity [2]
CALCIPOTRIOL folds Other
Class: Dermal filler Adverse effects [3]
Synonym: calcipotriene Half-life: N/A Dipsia (thirst) (2–3%) [3]
Trade name: Dovonex (Leo Pharma) Clinically important, potentially hazardous
Indications: Psoriasis interactions with: anticoagulants, antiplatelet
drugs, aspirin
Class: Antipsoriatic agent, Vitamin D analog
Half-life: ~30 minutes
CANAKINUMAB
Clinically important, potentially hazardous Skin Trade name: Ilaris (Novartis)
interactions with: none known Ecchymoses [2] Indications: Periodic fever syndromes, systemic
Pregnancy category: C Granulomas [5] juvenile idiopathic arthritis
Important contra-indications noted in the Necrosis [2] Class: Interleukin-1 inhibitor, Monoclonal
prescribing guidelines for: nursing mothers; Nodular eruption [3] antibody
pediatric patients Half-life: 26 days
Note: Contra-indicated in patients with acute
Mucosal
Oral lesions [3] Clinically important, potentially hazardous
psoriatic eruptions, hypercalcemia or vitamin D interactions with: cytochrome P450, IL-1
toxicity. blockers, lenalidomide, TNF-blockers
Skin CALFACTANT Important contra-indications noted in the
Burning (23%) prescribing guidelines for: nursing mothers;
Contact dermatitis [8] pediatric patients
Erythema (<10%) Note: Interleukin-1 blockade may interfere with
Pigmentation [3] immune response to infections. Treatment with
Pruritus (>10%) [6] CANAGLIFLOZIN medications that work through inhibition of IL-1
Psoriasis (<10%) [3] has been associated with an increased risk of
Rash (11%) Trade names: Invokamet (Janssen), Invokana serious infections.
Xerosis (<5%) (Janssen)
Class: Sodium-glucose co-transporter 2 (SGLT2)
Nasopharyngitis [3] Headache [2]
inhibitor
Endocrine/Metabolic Vertigo (dizziness) (11%) [2]
Half-life: 11–13 hours
Hypercalcemia [3] Clinically important, potentially hazardous Neuromuscular/Skeletal
Local interactions with: digoxin, rifampin Myalgia/Myopathy (11%)
Application-site pain [3] Pregnancy category: C Gastrointestinal/Hepatic
Application-site pruritus [2] Important contra-indications noted in the Gastroenteritis (11%) [2]
Application-site reactions [2] prescribing guidelines for: nursing mothers; Nausea (14%)
pediatric patients
Other Note: Contra-indicated in patients with severe
Respiratory
Adverse effects [3] Bronchitis (11%)
renal impairment, end stage renal disease, or on
Flu-like syndrome (20%)
dialysis. Invokamet is canagliflozin and metformin.
Nasopharyngitis (34%) [3]
CALCITONIN Cardiovascular
Pharyngitis (11%)
Rhinitis (17%)
Postural hypotension [2] Upper respiratory tract infection [4]
Trade names: Calcimar (Sanofi-Aventis),
Miacalcin (Novartis) Central Nervous System Endocrine/Metabolic
Indications: Paget’s disease of bone Headache [3] Weight gain (11%)
Class: Parathyroid hormone antagonist Neuromuscular/Skeletal Hematologic
Half-life: 7090 minutes Arthralgia [2] Macrophage activation syndrome [2]
Clinically important, potentially hazardous Asthenia (fatigue) (2%) Neutropenia [2]
interactions with: none known Back pain [2]
Pregnancy category: C Local
Gastrointestinal/Hepatic Injection-site reactions [4]
Cardiovascular Constipation (2%) [2]
Other
Flushing (>10%) [5] Adverse effects [4]
Diarrhea [2]
Infection [11]
Gastrointestinal/Hepatic Nausea (2%) [4]
Diarrhea [2] Respiratory
Nausea [2] Nasopharyngitis [2]
Respiratory Upper respiratory tract infection [2]
Rhinitis (12%) Endocrine/Metabolic
Local Hypoglycemia [7]
Injection-site edema (>10%) Genitourinary
Injection-site inflammation (>10%) [2] Genital mycotic infections (4–11%) [27]
Injection-site reactions (10%) Pollakiuria [6]
Litt’s Drug Eruption & Reaction Manual CAPREOMYCIN
Hematologic QT prolongation [2]

CANDESARTAN Bleeding (<15%) [7] Thromboembolism [2]
Ventricular fibrillation [2]
Trade name: Atacand (AstraZeneca)
Indications: Hypertension and heart failure Central Nervous System
Class: Angiotensin II receptor antagonist CAPECITABINE Anorexia [12]
(blocker), Antihypertensive Fever [2]
Half-life: 9 hours Trade name: Xeloda (Roche) Headache [2]
Clinically important, potentially hazardous Indications: Metastatic breast or colorectal Leukoencephalopathy [5]
interactions with: aliskiren cancer, adjuvant colon cancer Neurotoxicity [14]
Pregnancy category: D Class: Antimetabolite, Antineoplastic Pain [4]
Important contra-indications noted in the Half-life: 0.5–1 hour Paresthesias (21%)
prescribing guidelines for: nursing mothers; Clinically important, potentially hazardous Peripheral neuropathy [11]
pediatric patients interactions with: allopurinol, anticoagulants, Vertigo (dizziness) [3]
Warning: FETAL TOXICITY CYP2C9 substrates, erlotinib, leucovorin, Neuromuscular/Skeletal
phenprocoumon, phenytoin, warfarin Asthenia (fatigue) [50]
Pregnancy category: D Ataxia [2]
Skin Important contra-indications noted in the
Angioedema [3] Myalgia/Myopathy (9%) [3]
prescribing guidelines for: nursing mothers Pain in extremities [2]
Cardiovascular Note: Patients receiving concomitant
Hypotension [5] capecitabine and oral coumarin-derivative Gastrointestinal/Hepatic
anticoagulants such as warfarin and Abdominal pain [9]
Central Nervous System Constipation [3]
Dysgeusia (taste perversion) [2] phenprocoumon should have their anticoagulant
response (INR or prothrombin time) monitored Diarrhea [72]
Headache [5] Hepatotoxicity [6]
Vertigo (dizziness) (4%) [6] frequently in order to adjust the anticoagulant
dose accordingly. Altered coagulation parameters Ileus [2]
Neuromuscular/Skeletal and/or bleeding, including death, have been Nausea [36]
Back pain (3%) [3] reported during concomitant use. Vomiting [29]
Gastrointestinal/Hepatic Contra-indicated in patients with severe renal Respiratory
Gastroenteritis [2] impairment or with known hypersensitivity to Nasopharyngitis [2]
fluorouracil. Endocrine/Metabolic
Respiratory
Warning: XELODA - WARFARIN ALT increased [5]
Pharyngitis (2%)
INTERACTION Appetite decreased [2]
Rhinitis (2%)
Upper respiratory tract infection (6%) [3] AST increased [5]
Endocrine/Metabolic Skin Hyperammonemia [2]
Hyperkalemia (2%) Acneform eruption [3] Hyperbilirubinemia [4]
Actinic keratoses [3] Hyperglycemia [3]
Renal Dermatitis (37%) [10] Hypertriglyceridemia [2]
Renal failure [3] Edema (9%) [3] Hypophosphatemia [2]
Hematologic Exfoliative dermatitis (3137%) Hematologic
Neutropenia [2] Hand–foot syndrome (758%) [167] Anemia [24]
Jaundice [3] Febrile neutropenia [4]
Other
Lupus erythematosus [4] Hemotoxicity [2]
Adverse effects [4]
Photosensitivity [2] Leukocytopenia [3]
Fetotoxicity [2]
Pigmentation [10] Leukopenia [14]
Pruritus [2] Neutropenia [44]
Radiation recall dermatitis [6] Thrombocytopenia [20]
CANGRELOR Rash [14]
Toxicity [4] Other
Trade name: Kengreal (Medicines Co) Vitiligo [2] Adverse effects [6]
Indications: Adjunct to percutaneous coronary Xerosis [2] Allergic reactions [2]
intervention for reducing the risk of Death [7]
Hair Infection [2]
periprocedural myocardial infarction, repeat
Alopecia [10]
coronary revascularization and stent thrombosis
Class: Antiplatelet, Antiplatelet, cyclopentyl Nails
triazolo-pyrimidine (CPTP) Nail changes (7%) CAPREOMYCIN
Half-life: 3–6 minutes Onycholysis [3]
Clinically important, potentially hazardous Onychomadesis [2] See: www.drugeruptiondata.com/drug/id/1025
interactions with: clopidogrel, prasugrel Paronychia [2]
Pregnancy category: C Pyogenic granuloma [2]
Important contra-indications noted in the Mucosal
prescribing guidelines for: nursing mothers; Mucosal inflammation [2]
pediatric patients Mucositis [16]
Note: Contra-indicated in patients with Stomatitis (24%) [19]
significant active bleeding.
Cardiovascular
Angina [4]
Respiratory Cardiotoxicity [4]
Dyspnea [5] Chest pain [3]
Renal Coronary vasospasm [4]
Nephrotoxicity (3%) Hypertension [6]
Myocardial infarction [4]
CAPTOPRIL See all our books at www.crcpress.com
Pseudolymphoma [2] delavirdine, dexamethasone, diltiazem,

CAPTOPRIL Psoriasis [8] doxacurium, doxycycline, dronedarone,
Rash (47%) [12] efavirenz, elbasvir & grazoprevir, eliglustat,
Trade names: Capoten (Par), Capozide (Par) Toxic epidermal necrolysis [3] emtricitabine/rilpivirine/tenofovir alafenamide,
Indications: Hypertension, congestive heart Urticaria [9] enzalutamide, erythromycin, eslicarbazepine,
failure, to improve survival following myocardial Vasculitis [7] estradiol, ethosuximide, etravirine, ezogabine,
infarction in clinically stable patients with left felodipine, fesoterodine, flibanserin,
ventricular dysfunction, diabetic nephropathy in Hair
Alopecia (<2%) [4] fosamprenavir, gefitinib, glecaprevir &
patients with Type I insulin-dependent diabetes pibrentasvir, ibrutinib, idelalisib, imatinib,
mellitus and retinopathy Nails indinavir, influenza vaccine, isavuconazonium
Class: Angiotensin-converting enzyme (ACE) Nail dystrophy [2] sulfate, isotretinoin, itraconazole, ixabepilone,
inhibitor, Antihypertensive, Vasodilator Onycholysis [2] ixazomib, lacosamide, lapatinib, ledipasvir &
Half-life: <3 hours Mucosal sofosbuvir, lesinurad, levetiracetam,
Clinically important, potentially hazardous Aphthous stomatitis (<2%) [5] levomepromazine, levonorgestrel, linezolid,
interactions with: alcohol, aldesleukin, Glossitis [3] lopinavir, methylprednisolone, midazolam,
allopurinol, alpha blockers, alprostadil, amifostine, Oral mucosal eruption [3] midostaurin, mifepristone, naldemedine,
amiloride, angiotensin II receptor antagonists, Oral ulceration [4] nelfinavir, neratinib, nevirapine, nifedipine,
antacids, antidiabetics, antihypertensives, Sialadenitis [2] nilotinib, nintedanib, olanzapine, olaparib,
antipsychotics, anxiolytics and hypnotics, Tongue ulceration [3] ombitasvir/paritaprevir/ritonavir, ondansetron,
aprotinin, azathioprine, baclofen, beta blockers, Xerostomia (<2%) osimertinib, oxcarbazepine, oxtriphylline,
calcium channel blockers, clonidine, cyclosporine, paclitaxel, palbociclib, paliperidone, perampanel,
CYP2D6 inhibitors, darunavir, diazoxide, digoxin, Cardiovascular
Flushing [2] pimavanserin, piracetam, ponatinib, prednisolone,
diuretics, eplerenone, estrogens, everolimus, propoxyphene, regorafenib, rilpivirine, riociguat,
general anesthetics, gold & gold compounds, Central Nervous System risperidone, ritonavir, rivaroxaban, roflumilast,
heparins, herbals, hydralazine, hypotensives, Ageusia (taste loss) (24%) [11] romidepsin, rufinamide, simeprevir, simvastatin,
insulin, interferon alfa, levodopa, lithium, MAO Dysgeusia (taste perversion) (metallic or sodium picosulfate, sofosbuvir, sofosbuvir &
inhibitors, metformin, methyldopa, salty taste) (24%) [14] velpatasvir, sofosbuvir/velpatasvir/voxilaprevir,
methylphenidate, minoxidil, moxisylyte, Hallucinations [2] solifenacin, sonidegib, sorafenib, St John’s wort,
moxonidine, naldemedine, nitrates, nitroprusside, Paresthesias (<2%) sunitinib, telaprevir, telithromycin, temsirolimus,
NSAIDs, pentoxifylline, phosphodiesterase 5 Gastrointestinal/Hepatic tenofovir alafenamide, terbinafine, thalidomide,
inhibitors, potassium salts, probenecid, Hepatotoxicity [3] tiagabine, ticagrelor, tipranavir, tolvaptan,
prostacyclin analogues, rituximab, salicylates, Nausea [2] tramadol, triamcinolone, troleandomycin,
sirolimus, spironolactone, sulfonylureas, ulipristal, valbenazine, vandetanib, vemurafenib,
temsirolimus, tizanidine, tolvaptan, triamterene, Respiratory
venetoclax, verapamil, vorapaxar, voriconazole,
trimethoprim, venetoclax, yohimbine Cough [19]
vortioxetine, ziprasidone, zuclopenthixol
Pregnancy category: D (category C in first Endocrine/Metabolic Pregnancy category: D
trimester; category D in second and third Gynecomastia [3] Note: Carbamazepine is the main cause of
trimesters) Renal Stevens-Johnson syndrome (SJS), toxic epidermal
Important contra-indications noted in the necrolysis (TEN), and the hypersensitivity
Nephrotoxicity [2]
prescribing guidelines for: nursing mothers; syndrome in Han Chinese, and in peoples of
pediatric patients Other
other Southeast Asian countries, as a result of a
Note: Capozide is captopril and Adverse effects [4]
strong pharmacogenetic association that has been
hydrochlorothiazide. Hydrochlorothiazide is a Allergic reactions [2]
reported in these patients between the human
sulfonamide and can be absorbed systemically. leukocyte antigen (HLA)-B*1502 and
Sulfonamides can produce severe, possibly fatal, carbamazepine.
reactions such as toxic epidermal necrolysis and CARBACHOL Warning: SERIOUS DERMATOLOGIC
Stevens-Johnson syndrome. REACTIONS AND HLA-B*1502 ALLELE;
Warning: FETAL TOXICITY See: www.drugeruptiondata.com/drug/id/1042 APLASTIC ANEMIA AND AGRANULOCYTOSIS
Skin Skin
Angioedema (<15%) [45] CARBAMAZEPINE AGEP [5]
Bullous pemphigoid [2] Angioedema [5]
Dermatitis [3] Trade names: Epitol (Teva), Tegretol (Novartis) Anticonvulsant hypersensitivity syndrome
DRESS syndrome [2] Indications: Epilepsy, pain or trigeminal neuralgia [19]
Erythroderma [2] Class: Anticonvulsant, Antipsychotic, CYP1A2 Bullous dermatitis [4]
Exanthems (47%) [19] inducer, CYP3A4 inducer, Mood stabilizer Dermatitis [7]
Exfoliative dermatitis (<2%) [4] Half-life: 1855 hours Diaphoresis (<10%)
Kaposi’s sarcoma [2] Clinically important, potentially hazardous DRESS syndrome [48]
Lichen planus pemphigoides [2] interactions with: abiraterone, acetaminophen, Eczema [2]
Lichenoid eruption [12] acetylcysteine, adenosine, afatinib, amitriptyline, Erythema multiforme [16]
Linear IgA bullous dermatosis [5] amlodipine, amprenavir, apixaban, apremilast, Erythroderma [12]
Lupus erythematosus [8] aprepitant, aripiprazole, artemether/lumefantrine, Exanthems (>5%) [35]
Mycosis fungoides [2] boceprevir, brigatinib, brivaracetam, Exfoliative dermatitis [24]
Pemphigus (<2%) [23] buprenorphine, cabazitaxel, cabozantinib, Facial edema [2]
Pemphigus foliaceus [2] caffeine, caspofungin, cefixime, ceritinib, charcoal, Fixed eruption [10]
Penile ulceration [2] citalopram, clarithromycin, clobazam, Hypersensitivity [71]
Photosensitivity [3] clopidogrel, clorazepate, clozapine, cobicistat/ Lichen planus [2]
Phototoxicity (<2%) elvitegravir/emtricitabine/tenofovir disoproxil, Lichenoid eruption [8]
Pigmentation [2] cobimetinib, copanlisib, crizotinib, dabigatran, Lupus erythematosus [35]
Pityriasis rosea (<2%) [6] daclatasvir, darunavir, dasabuvir/ombitasvir/ Lymphoma [2]
Pruritus (<7%) [8] paritaprevir/ritonavir, dasatinib, deflazacort,
Litt’s Drug Eruption & Reaction Manual CARFILZOMIB
Lymphoproliferative disease [5] Death [6] Paresthesias [2]

Mycosis fungoides [3] Side effects [3] Peripheral neuropathy [8]
Pemphigus [3] Teratogenicity [12] Vertigo (dizziness) [2]
Photosensitivity [9] Neuromuscular/Skeletal
Pruritus [7] Asthenia (fatigue) [22]
Pseudolymphoma [17]
Purpura [8]
CARBENICILLIN Myalgia/Myopathy [2]
Pustules [5] Gastrointestinal/Hepatic
See: www.drugeruptiondata.com/drug/id/100 Constipation [3]
Rash (>10%) [30]
Serum sickness [2] Diarrhea [13]
Stevens-Johnson syndrome (<10%) [98] Dyspepsia [2]
Toxic epidermal necrolysis (<10%) [88] CARBETOCIN Gastrointestinal perforation [2]
Toxic pustuloderma [3] Hepatotoxicity [4]
Toxicity [2] See: www.drugeruptiondata.com/drug/id/1372 Nausea [15]
Urticaria [14] Pancreatitis [2]
Vasculitis [7] Vomiting [16]
Hair CARBIMAZOLE Respiratory
Alopecia [7] Cough [2]
See: www.drugeruptiondata.com/drug/id/1277 Hemoptysis [2]
Mucosal Pneumonia [2]
Mucocutaneous eruption [4] Pulmonary toxicity [3]
Mucocutaneous lymph node syndrome
(Kawasaki syndrome) [2] CARBINOXAMINE Endocrine/Metabolic
Oral ulceration [2] ALT increased [3]
Tongue ulceration [2] See: www.drugeruptiondata.com/drug/id/1026 AST increased [2]
Hyperglycemia [5]
Cardiovascular Hyponatremia [3]
Bradycardia [3]
Myocarditis [2] CARBOPLATIN SIADH [3]
Renal
Central Nervous System Trade name: Paraplatin (Bristol-Myers Squibb) Nephrotoxicity [9]
Ageusia (taste loss) [3] Indications: Various carcinomas and sarcomas
Coma [2] Hematologic
Class: Alkylating agent, Antineoplastic
Dysgeusia (taste perversion) [2] Anemia [25]
Half-life: terminal: 2240 hours
Headache [5] Febrile neutropenia [18]
Memory loss [2] Hemorrhage [2]
interactions with: aldesleukin, bexarotene
Seizures [12] Hemotoxicity [8]
Somnolence (drowsiness) [8] Leukopenia [11]
Tic disorder [4] Lymphopenia [2]
Vertigo (dizziness) [8] Myelosuppression [2]
mothers; pediatric patients
Myelotoxicity [2]
Neuromuscular/Skeletal Neutropenia [48]
Asthenia (fatigue) [3] Skin Pancytopenia [2]
Ataxia [5] Anaphylactoid reactions/Anaphylaxis [5] Thrombocytopenia [35]
Myasthenia gravis [2] Erythema (2%) [2]
Osteoporosis [2] Otic
Exanthems [3] Ototoxicity [7]
Gastrointestinal/Hepatic Hand–foot syndrome [4] Tinnitus [3]
Diarrhea [2] Hypersensitivity (2%) [27]
Hepatotoxicity [11] Pigmentation [2] Local
Nausea [5] Pruritus (2%) [2] Injection-site pain (>10%)
Pancreatitis [3] Radiation recall dermatitis [2] Other
Vanishing bile duct syndrome [4] Rash (2%) [9] Adverse effects [2]
Vomiting [3] Scleroderma [2] Allergic reactions [3]
Endocrine/Metabolic Toxicity [5] Death [4]
Acute intermittent porphyria [5] Urticaria (2%) [4] Infection [5]
Hyponatremia [4] Hair
SIADH [17] Alopecia (3%) [16]
Weight gain [5] Alopecia areata [2] CARFILZOMIB
Renal Mucosal
Nephrotoxicity [2] Epistaxis (nosebleed) [2] Trade name: Kyprolis (Onyx)
Mucositis [4] Indications: Multiple myeloma
Hematologic Class: Proteasome inhibitor
Agranulocytosis [2] Stomatitis (>10%) [2]
Half-life: ~1 hour
Leukopenia [3] Cardiovascular Clinically important, potentially hazardous
Thrombocytopenia [3] Flushing [3] interactions with: none known
Otic Hypertension [7] Pregnancy category: D
Hallucinations, auditory [2] Central Nervous System Important contra-indications noted in the
Ocular Anorexia [7] prescribing guidelines for: nursing mothers;
Diplopia [2] Headache [2] pediatric patients
Leukoencephalopathy [2]
Other Neurotoxicity [15]
Adverse effects [8] Skin
Pain [2] Herpes zoster (reactivation) (2%) [2]
CARFILZOMIB Over 100 updates per week on www.drugeruptiondata.com
Peripheral edema (24%) [3] Other

Tumor lysis syndrome [2] CARIPRAZINE Adverse effects [3]
Cardiovascular Toothache (3–6%) [2]
Trade name: Vraylar (Forest)
Cardiac failure (7%) [2] Indications: Schizophrenia, manic or mixed
Cardiotoxicity [6] episodes associated with bipolar I disorder
Chest pain (11%) Class: Antipsychotic CARISOPRODOL
Hypertension (14%) [6] Half-life: 2–4 days
Central Nervous System Clinically important, potentially hazardous Trade name: Soma (MedPointe)
Anorexia (12%) interactions with: CYP3A4 inducers Indications: Painful musculoskeletal disorders
Chills (16%) Pregnancy category: N/A (Neonatal risk in Class: Central muscle relaxant
Fever (30%) [7] third trimester exposure) Half-life: 46 hours
Headache (28%) [3] Important contra-indications noted in the Clinically important, potentially hazardous
Hypoesthesia (12%) prescribing guidelines for: the elderly; nursing interactions with: CNS depressants, eucalyptus,
Insomnia (18%) [2] mothers; pediatric patients meprobamate
Pain (12%) Warning: INCREASED MORTALITY IN Pregnancy category: C
Peripheral neuropathy (14%) [14] ELDERLY PATIENTS WITH DEMENTIA- Important contra-indications noted in the
Vertigo (dizziness) (13%) RELATED PSYCHOSIS prescribing guidelines for: the elderly; nursing
Neuromuscular/Skeletal Note: Contra-indicated in patients with acute
Arthralgia (16%) Skin intermittent porphyria.
Asthenia (fatigue) (13–56%) [16] Rash (<2%)
Back pain (20%) Mucosal
Muscle spasm (14%) [2] Skin
Oropharyngeal pain (<3%) Angioedema (<10%)
Pain in extremities (13%) Xerostomia (<3%) Fixed eruption [2]
Gastrointestinal/Hepatic Cardiovascular Urticaria [2]
Constipation (21%) [3] Hypertension (2–6%)
Diarrhea (33%) [6] Cardiovascular
Tachycardia (<3%) Flushing (<10%)
Nausea (45%) [14]
Vomiting (22%) [4] Central Nervous System Central Nervous System
Agitation (3–5%) Amnesia [2]
Respiratory Akathisia (20–21%) [23]
Cough (26%) [5] Trembling (<10%)
Anxiety (3–6%) [3]
Dyspnea (35%) [10] Extrapyramidal symptoms (15–29%) [18] Other
Pneumonia (13%) [6] Fever (<4%) [4] Death [2]
Pulmonary hypertension (2%) Headache (9–18%) [10]
Upper respiratory tract infection (28%) [5] Insomnia (8–13%) [13]
Endocrine/Metabolic Mania (worsening) [2] CARMUSTINE
AST increased (13%) Parkinsonism (13–26%) [4]
Hypercalcemia (11%) Restlessness (4–7%) [8] Trade names: BiCNU (Bristol-Myers Squibb),
Hyperglycemia (12%) [3] Schizophrenia (worsening) [3] Gliadel Wafer (Guilford)
Hypokalemia (14%) [3] Sedation [7] Indications: Brain tumors, Hodgkin’s disease,
Hypomagnesemia (14%) Somnolence (drowsiness) (5–10%) [4] multiple myeloma
Hyponatremia (10%) [2] Tremor [10] Class: Alkylating agent, Nitrosourea
Hypophosphatemia (11%) [3] Vertigo (dizziness) (3–7%) [8] Half-life: initial: 1.4 minutes; secondary: 20
Serum creatinine increased [5] Neuromuscular/Skeletal minutes
Renal Arthralgia (<2%) Clinically important, potentially hazardous
Nephrotoxicity [3] Asthenia (fatigue) (<5%) interactions with: aldesleukin, cimetidine,
Back pain (<3%) clorazepate
Hematologic Pregnancy category: D
Anemia (47%) [20] Dystonia (2–5%) [2]
Pain in extremities [2] Important contra-indications noted in the
Hemotoxicity [2] prescribing guidelines for: nursing mothers;
Leukopenia (14%) [4] Gastrointestinal/Hepatic pediatric patients
Lymphopenia (24%) [7] Abdominal pain (3–8%) [2]
Neutropenia (21%) [10] Constipation (6–11%) [11]
Thrombocytopenia (36%) [18] Diarrhea (<5%) [5] Skin
Dyspepsia (4–9%) [6] Dermatitis [3]
Other Pigmentation (on accidental contact) [2]
Adverse effects [3] Hepatotoxicity (<3%)
Nausea (5–13%) [11] Telangiectasia [2]
Vomiting (4–10%) [9] Hair
Respiratory Alopecia (<10%)
CARGLUMIC ACID Cough (<4%) Mucosal
See: www.drugeruptiondata.com/drug/id/1671 Nasopharyngitis (<2%) Stomatitis (<10%)
Endocrine/Metabolic Cardiovascular
Appetite decreased (<4%) Flushing (<10%) [2]
Creatine phosphokinase increased (<3%) Central Nervous System
Weight gain (2–3%) [7] Intracranial hemorrhage [2]
Genitourinary Meningococcal infection [2]
Urinary tract infection (<2%) Seizures [2]
Ocular Neuromuscular/Skeletal
Vision blurred (4%) [3] Asthenia (fatigue) [2]
Litt’s Drug Eruption & Reaction Manual CASPOFUNGIN
Gastrointestinal/Hepatic Respiratory Mucosal

Nausea [2] Cough (5–8%) Epistaxis (nosebleed) (<5%)
Vomiting [2] Dyspnea [4] Mucosal inflammation (6–10%)
Hematologic Stridor [2] Cardiovascular
Leukopenia [2] Endocrine/Metabolic Arrhythmias (<5%)
Thrombocytopenia [2] ALP increased (<3%) [2] Atrial fibrillation (<5%)
Local Creatine phosphokinase increased (<3%) Bradycardia (<5%)
Injection-site burning (>10%) [3] Cardiac arrest (<5%)
Diabetes mellitus (<3%) Flushing (3%)
GGT increased (<3%) Hypertension (5–10%)
Hypercholesterolemia (<4%) Hypotension (6–12%)
CARTEOLOL Hyperglycemia (5–12%) Myocardial infarction (<5%)
Hyperkalemia (<3%) [2] Phlebitis (18%) [3]
See: www.drugeruptiondata.com/drug/id/105 Hyperuricemia (<3%) Tachycardia (4–7%)
Hypervolemia (<3%) Thrombophlebitis [2]
Hypoglycemia (<3%) Central Nervous System
CARVEDILOL Hyponatremia (<3%) Anxiety (<5%)
Hypovolemia (<3%) Chills (9–23%)
Trade name: Coreg (GSK) Weight gain (10–12%) Confusion (<5%)
Indications: Hypertension Weight loss (<3%) Depression (<5%)
Class: Adrenergic beta-receptor antagonist Genitourinary Fever (6–29%) [8]
Half-life: 710 hours Albuminuria (<3%) Headache (5–15%) [3]
Clinically important, potentially hazardous Hematuria (<3%) Insomnia (<5%)
interactions with: cinacalcet, delavirdine, Impotence (<3%) Pain (<5%)
efavirenz, irbesartan, leflunomide, propafenone, Paresthesias (<3%)
trimethoprim, venetoclax, voriconazole, Hematologic
Anemia [2] Seizures (<5%)
zafirlukast Tremor (<2%)
Pregnancy category: C Prothrombin time decreased (<3%)
Thrombocytopenia (<3%) Vertigo (dizziness) (<5%)
prescribing guidelines for: nursing mothers; Ocular Neuromuscular/Skeletal
pediatric patients Abnormal vision (5%) Arthralgia (<5%)
Vision blurred (<3%) Asthenia (fatigue) (<5%)
Back pain (<5%)
Skin Other Myalgia/Myopathy (~3%)
Diaphoresis (3%) Adverse effects [8] Pain in extremities (<5%)
Edema (generalized) (5–6%) [2] Infection (2%)
Peripheral edema (<7%) Gastrointestinal/Hepatic
Purpura (<3%) Abdominal distension (<5%)
Cardiovascular CASPOFUNGIN Constipation (<5%)
Angina (2–6%) Diarrhea (6–27%)
Atrial fibrillation [2] Trade name: Cancidas (Merck) Dyspepsia (<5%)
Atrioventricular block (<3%) Indications: Invasive Aspergillus and Candida Hepatic failure (<5%)
Bradycardia (2–10%) [7] infections Hepatotoxicity (<5%) [8]
Cardiac failure [2] Class: Antifungal Nausea (5–15%) [2]
Congestive heart failure [2] Half-life: beta phase: 9–11 hours; terminal: 40–50 Vomiting (9–17%) [2]
Extrasystoles [2] hours
Hypertension (<3%) Clinically important, potentially hazardous Respiratory
Hypotension (9–14%) [8] interactions with: carbamazepine, cyclosporine, Cough (6–11%)
Palpitation (<3%) dexamethasone, efavirenz, nevirapine, phenytoin, Dyspnea (9%)
Postural hypotension (<3%) rifampin, tacrolimus Flu-like syndrome (3%)
Pregnancy category: C Hypoxia (<5%)
Central Nervous System Pleural effusion (9%)
Fever (<3%) Important contra-indications noted in the
prescribing guidelines for: nursing mothers; Pneumonia (4–11%)
Headache (5–8%) [2] Respiratory distress (8%)
Pain (9%) pediatric patients
Respiratory failure (6–11%)
Paresthesias (2%) Tachypnea (8%)
Somnolence (drowsiness) (<3%) Skin
Syncope (3–8%) Anaphylactoid reactions/Anaphylaxis (<2%) Endocrine/Metabolic
Vertigo (dizziness) (24–32%) [5] Edema (~3%) ALP increased (12–23%) [4]
Erythema (<4%) ALT increased (4–18%) [4]
Neuromuscular/Skeletal Appetite decreased (<5%)
Arthralgia (<6%) Facial edema (3%)
Jaundice (<5%) AST increased (6–16%) [5]
Asthenia (fatigue) (7–24%) [2] Hypercalcemia (<5%)
Muscle spasm (<3%) Peripheral edema (11%)
Petechiae (<5%) Hyperglycemia (<5%)
Myalgia/Myopathy (3%) Hypokalemia (6–8%) [3]
Pruritus (2–7%)
Gastrointestinal/Hepatic Rash (4–16%) [5] Hypomagnesemia (<5%)
Black stools (<3%) Septic–toxic shock (11–13%) Genitourinary
Diarrhea (2–12%) Ulcerations (3%) Hematuria (<5%)
Nausea (4–9%) Urticaria (<5%) Urinary tract infection (<5%)
Vomiting (<6%) Vasculitis (2%) Renal
Nephrotoxicity [5]
CASPOFUNGIN See all our books at www.crcpress.com
Renal failure (<5%) Pregnancy category: B

Hematologic Important contra-indications noted in the CEFEPIME
Anemia (2–11%) prescribing guidelines for: nursing mothers
Note: Penicillin and cephalosporins share a Trade name: Maxipime (Elan)
Coagulopathy (<5%) Indications: Various infections caused by
Eosinophilia [2] common beta-lactam structure. People who are
allergic to penicillin are approximately 4 times susceptible organisms
Febrile neutropenia (<5%) Class: Cephalosporin, 4th generation
Neutropenia (<5%) more likely to develop an allergic reaction to a
cephalosporin than those people who have no Half-life: 22.3 hours
Sepsis (5%) Clinically important, potentially hazardous
Thrombocytopenia (<5%) [2] penicillin allergy (from 5–16% of patients allergic
to penicillin develop reactions to cephalosporins). interactions with: none known
Local Pregnancy category: B
Infusion-related reactions [4] Important contra-indications noted in the
Infusion-site pain (<5%) Skin prescribing guidelines for: the elderly; nursing
Infusion-site reactions (<5%) [2] Urticaria [2] mothers
Injection-site induration (~3%) Gastrointestinal/Hepatic Note: Penicillin and cephalosporins share a
Injection-site reactions (212%) [4] Diarrhea [2] common beta-lactam structure. People who are
Other Nausea [2] allergic to penicillin are approximately 4 times
Adverse effects [8] Other more likely to develop an allergic reaction to a
Adverse effects [3] cephalosporin than those people who have no
penicillin allergy (from 5–16% of patients allergic
to penicillin develop reactions to cephalosporins).
CEFACLOR
CEFAMANDOLE Skin
Trade name: Ceclor (Lilly)
Indications: Various infections caused by See: www.drugeruptiondata.com/drug/id/109 Exanthems (2%)
susceptible organisms Hypersensitivity [2]
Class: Cephalosporin, 2nd generation Lupus erythematosus [2]
Pruritus [3]
Half-life: 0.60.9 hours
CEFAZOLIN Rash (51%) [12]
interactions with: none known See: www.drugeruptiondata.com/drug/id/110 Central Nervous System
Pregnancy category: B Encephalopathy [10]
Important contra-indications noted in the Headache [3]
prescribing guidelines for: the elderly; nursing Neurotoxicity [14]
mothers; pediatric patients CEFDINIR Seizures [16]
Note: Penicillin and cephalosporins share a Status epilepticus [5]
common beta-lactam structure. People who are Trade name: Omnicef (Medicis)
Indications: Community-acquired pneumonia Neuromuscular/Skeletal
allergic to penicillin are approximately 4 times Myoclonus [2]
more likely to develop an allergic reaction to a and various infections caused by susceptible
cephalosporin than those people who have no organisms Local
penicillin allergy (from 5–16% of patients allergic Class: Cephalosporin, 3rd generation Injection-site reactions (3%) [2]
to penicillin develop reactions to cephalosporins). Half-life: 12 hours Other
Adverse effects [2]
Skin Pregnancy category: B
AGEP [2] Important contra-indications noted in the
Anaphylactoid reactions/Anaphylaxis [4] prescribing guidelines for: pediatric patients CEFIXIME
Erythema multiforme [6] Note: Penicillin and cephalosporins share a
Exanthems [9] common beta-lactam structure. People who are Trade name: Suprax (Lupin)
Fixed eruption [2] allergic to penicillin are approximately 4 times Indications: Various infections caused by
Pruritus [4] more likely to develop an allergic reaction to a susceptible organisms
Purpura [2] cephalosporin than those people who have no Class: Cephalosporin, 3rd generation
Rash (<2%) [2] penicillin allergy (from 5–16% of patients allergic Half-life: 34 hours
Serum sickness [7] to penicillin develop reactions to cephalosporins). Clinically important, potentially hazardous
Serum sickness-like reaction [23] interactions with: aminoglycosides,
Urticaria [5] anticoagulants, BCG vaccine, carbamazepine,
Skin probenecid, typhoid vaccine, warfarin
Gastrointestinal/Hepatic Rash (3%)
Diarrhea [2] Pregnancy category: B
Gastrointestinal/Hepatic Important contra-indications noted in the
Other Red stools [2] prescribing guidelines for: nursing mothers;
Adverse effects [3] pediatric patients
Genitourinary
Vulvovaginal candidiasis (5%) Note: Penicillin and cephalosporins share a
common beta-lactam structure. People who are
CEFADROXIL Other allergic to penicillin are approximately 4 times
Adverse effects [2] more likely to develop an allergic reaction to a
Trade name: Duricef (Warner Chilcott) cephalosporin than those people who have no
Indications: Various infections caused by penicillin allergy (from 5–16% of patients allergic
susceptible organisms CEFDITOREN to penicillin develop reactions to cephalosporins).
Class: Cephalosporin, 1st generation
Half-life: 1.21.5 hours See: www.drugeruptiondata.com/drug/id/903 Skin
Clinically important, potentially hazardous Anaphylactoid reactions/Anaphylaxis (<2%)
interactions with: none known Angioedema (<2%)
Erythema multiforme (<2%)
Litt’s Drug Eruption & Reaction Manual CEFTAROLINE FOSAMIL
Facial edema (<2%) DRESS syndrome [4]

Jaundice (<2%) Erythema multiforme [2] CEFTAROLINE
Pruritus (<2%) Exanthems [3]
Pruritus ani et vulvae (<2%) Hypersensitivity [2] FOSAMIL
Rash (<2%) [2] Pruritus (2%) [3]
Trade name: Teflaro (Forest)
Serum sickness-like reaction (<2%) Rash (2%) [3]
Indications: Acute bacterial skin and skin
Stevens-Johnson syndrome (<2%) Urticaria (2%)
structure infections, community-acquired
Toxic epidermal necrolysis (<2%) Local bacterial pneumonia
Urticaria (<2%) [2] Injection-site inflammation (4%) Class: Antibacterial, Cephalosporin, 5th
Central Nervous System Injection-site pain (<10%) generation
Fever (<2%) Other Half-life: 3 hours
Gastrointestinal/Hepatic Adverse effects [2] Clinically important, potentially hazardous
Abdominal pain (3%) interactions with: BCG vaccine, probenecid,
Diarrhea (16%) typhoid vaccine
Dyspepsia (3%)
Flatulence (4%)
CEFOTETAN Important contra-indications noted in the
Hepatitis (<2%) prescribing guidelines for: the elderly; nursing
Indications: Various infections caused by
Loose stools (6%) mothers; pediatric patients
susceptible organisms
Nausea (7%) Note: Penicillin and cephalosporins share a
Class: Cephalosporin, 2nd generation
Pseudomembranous colitis (<2%) common beta-lactam structure. People who are
Half-life: 35 hours
allergic to penicillin are approximately 4 times
Endocrine/Metabolic Clinically important, potentially hazardous
more likely to develop an allergic reaction to a
ALP increased (<2%) interactions with: none known
cephalosporin than those people who have no
Creatine phosphokinase increased (<2%) Pregnancy category: B
penicillin allergy (from 5–16% of patients allergic
Genitourinary Important contra-indications noted in the
Vaginitis (<2%) prescribing guidelines for: nursing mothers;
Vulvovaginal candidiasis (<2%) pediatric patients
Note: Penicillin and cephalosporins share a Skin
Renal common beta-lactam structure. People who are Anaphylactoid reactions/Anaphylaxis (<2%)
Renal failure (<2%) allergic to penicillin are approximately 4 times Hypersensitivity (<2%) [2]
more likely to develop an allergic reaction to a Pruritus [7]
cephalosporin than those people who have no Rash (3%) [9]
CEFMETAZOLE penicillin allergy (from 5–16% of patients allergic Urticaria (<2%)
to penicillin develop reactions to cephalosporins). Cardiovascular
See: www.drugeruptiondata.com/drug/id/114 Bradycardia (<2%)
Skin Hypertension [2]
Anaphylactoid reactions/Anaphylaxis [3] Palpitation (<2%)
CEFONICID Rash [2] Phlebitis (2%) [3]
Hematologic Central Nervous System
See: www.drugeruptiondata.com/drug/id/115 Hemolytic anemia [12] Fever (<2%)
Headache [9]
Other
Insomnia [5]
Death [5]
CEFOPERAZONE Seizures (<2%)
See: www.drugeruptiondata.com/drug/id/116 Gastrointestinal/Hepatic
CEFOXITIN Abdominal pain (<2%)
Colitis (<2%)
CEFOTAXIME Constipation (2%)
Diarrhea (5%) [10]
Trade name: Claforan (Sanofi-Aventis) Hepatotoxicity (<2%)
Indications: Various infections caused by CEFPODOXIME Nausea (4%) [9]
susceptible organisms Vomiting (2%)
Class: Cephalosporin, 3rd generation See: www.drugeruptiondata.com/drug/id/120
Respiratory
Half-life: 1 hour (adults) Eosinophilic pneumonia [3]
Endocrine/Metabolic
interactions with: none known CEFPROZIL ALT increased (2%)
Hyperglycemia (<2%)
Important contra-indications noted in the See: www.drugeruptiondata.com/drug/id/121
Hyperkalemia (<2%)
Hypokalemia (2%) [2]
Note: Penicillin and cephalosporins share a
common beta-lactam structure. People who are Renal
allergic to penicillin are approximately 4 times Renal failure (<2%)
more likely to develop an allergic reaction to a Hematologic
cephalosporin than those people who have no Anemia (<2%)
penicillin allergy (from 5–16% of patients allergic Eosinophilia (<2%) [2]
to penicillin develop reactions to cephalosporins). Neutropenia (<2%) [3]
Thrombocytopenia (<2%)
Skin
Anaphylactoid reactions/Anaphylaxis (2%)
CEFTAROLINE FOSAMIL Over 100 updates per week on www.drugeruptiondata.com
Other Skin Skin

Adverse effects [4] Rash (<5%) Erythema (9%)
Infection [2] Pruritus (9%)
Anxiety (10%) [3]
Dysgeusia (taste perversion) (8%) [3]
Fever [4]
CEFTAZIDIME Headache [3] Headache [2]
Vertigo (dizziness) (6%) Gastrointestinal/Hepatic
Trade names: Ceptaz (GSK), Fortaz Abdominal pain [2]
(Concordia), Tazicef (Hospira) Gastrointestinal/Hepatic
Abdominal pain (7%) [5] Diarrhea [4]
Indications: Various infections caused by Nausea [6]
susceptible organisms Constipation (10%) [2]
Diarrhea [5] Vomiting [4]
Class: Cephalosporin, 3rd generation
Half-life: 12 hours Hepatotoxicity [4] Endocrine/Metabolic
Clinically important, potentially hazardous Nausea (2%) [5] Hyponatremia [2]
interactions with: none known Vomiting [5] Local
Pregnancy category: B Endocrine/Metabolic Infusion-site reactions [2]
Important contra-indications noted in the ALP increased (3%) Other
prescribing guidelines for: the elderly; nursing ALT increased (3%) [3] Adverse effects [3]
mothers AST increased [3]
Note: Penicillin and cephalosporins share a GGT increased (<5%)
common beta-lactam structure. People who are
allergic to penicillin are approximately 4 times
Renal
Nephrotoxicity (<5%)
CEFTOLOZANE &
more likely to develop an allergic reaction to a
cephalosporin than those people who have no
Renal failure (<5%) [4] TAZOBACTAM
penicillin allergy (from 5–16% of patients allergic Hematologic
Eosinophilia (<5%) Trade name: Zerbaxa (Cubist)
Prothrombin time increased (<5%) Indications: Various infections caused by
See also separate profile for Ceftazidime &
Thrombocytopenia (<5%) susceptible organisms
Avibactam.
Class: Antibacterial, Antibiotic, beta-lactam,
Local Cephalosporin, 5th generation
Skin Injection-site reactions [4] Half-life: <3 hours
Anaphylactoid reactions/Anaphylaxis (2%) Other Clinically important, potentially hazardous
[3] Adverse effects [2] interactions with: none known
Angioedema (2%) Pregnancy category: B
Erythema multiforme (2%) Important contra-indications noted in the
Hypersensitivity (2%)
Pemphigus erythematodes [2] CEFTIBUTEN prescribing guidelines for: the elderly; nursing
Pruritus (2%) [3]
Rash (2%) [5]
Stevens-Johnson syndrome (2%)
Cardiovascular
Hypertension [3]
Toxic epidermal necrolysis (2%)
Central Nervous System CEFTIZOXIME Central Nervous System
Fever (2%) [5]
Encephalopathy [2]
See: www.drugeruptiondata.com/drug/id/124 Headache (3%) [8]
Seizures [3]
Insomnia [2]
Local Somnolence (drowsiness) [2]
Injection-site inflammation (2%)
Injection-site reactions [2] CEFTOBIPROLE Neuromuscular/Skeletal
Myalgia/Myopathy [2]
Injection-site thrombophlebitis (2%)
Trade names: BAL5788 (Basilea) (Cilag AG), Gastrointestinal/Hepatic
Other Zeftera (Janssen) Constipation (4%) [4]
Adverse effects [3] Indications: Bacterial infections, MRSA Diarrhea (2%) [10]
Death [2] Class: Cephalosporin, 5th generation Nausea (3%) [11]
Half-life: 3 hours Vomiting [3]
Endocrine/Metabolic
CEFTAZIDIME & interactions with: alcohol, anticoagulants, BCG
ALT increased (2%)
vaccine, carbenicillin, dipyridamole, heparin,
AVIBACTAM pentoxifylline, plicamycin, sulfinpyrazone, AST increased (2%)
ticarcillin, typhoid vaccine, valproic acid Hematologic
Trade name: Avycaz (Cerexa) Pregnancy category: N/A (not recommended Anemia [2]
Indications: Various infections caused by in pregnancy)
Local
susceptible organisms Important contra-indications noted in the
Infusion-site reactions [2]
Class: Antibiotic, beta-lactam (avibactam), prescribing guidelines for: nursing mothers;
Cephalosporin, 3rd generation (ceftazidime) pediatric patients
Half-life: <3 hours Note: Penicillin and cephalosporins share a
Clinically important, potentially hazardous common beta-lactam structure. People who are
interactions with: probenecid allergic to penicillin are approximately 4 times
Pregnancy category: B more likely to develop an allergic reaction to a
Important contra-indications noted in the cephalosporin than those people who have no
prescribing guidelines for: the elderly; nursing penicillin allergy (from 5–16% of patients allergic
mothers; pediatric patients to penicillin develop reactions to cephalosporins).
Note: See also separate entry for ceftazidime.
Litt’s Drug Eruption & Reaction Manual CELECOXIB
Other epidermal necrolysis and Stevens-Johnson

CEFTRIAXONE Adverse effects [7] syndrome. NSAIDs may cause an increased risk
Death [9] of serious cardiovascular and gastrointestinal
Trade name: Rocephin (Roche) Side effects (3%) [2] adverse events, which can be fatal. This risk may
Indications: Various infections caused by increase with duration of use.
susceptible organisms Contra-indicated in patients with known
Class: Antibiotic, Cephalosporin, 3rd generation hypersensitivity to celecoxib, aspirin, or other
Half-life: 59 hours CEFUROXIME NSAIDs; in patients who have demonstrated
Clinically important, potentially hazardous allergic-type reactions to sulfonamides; in patients
interactions with: aminoglycosides, coumarins, Trade names: Ceftin (GSK), Zinacef (Concordia)
Indications: Various infections caused by who have experienced asthma, urticaria, or
histamine H2 antagonists, oral typhoid vaccine, allergic-type reactions after taking aspirin or other
probenecid susceptible organisms
Class: Cephalosporin, 2nd generation NSAIDs; and for the treatment of peri-operative
Pregnancy category: B pain in the setting of coronary artery bypass graft
Clinically important, potentially hazardous surgery.
prescribing guidelines for: nursing mothers; Warning: CARDIOVASCULAR AND
pediatric patients interactions with: none known
Pregnancy category: B GASTROINTESTINAL RISKS
Note: Penicillin and cephalosporins share a
common beta-lactam structure. People who are Important contra-indications noted in the
allergic to penicillin are approximately 4 times prescribing guidelines for: nursing mothers Skin
more likely to develop an allergic reaction to a Note: Penicillin and cephalosporins share a AGEP [7]
cephalosporin than those people who have no common beta-lactam structure. People who are Anaphylactoid reactions/Anaphylaxis [8]
penicillin allergy (from 5–16% of patients allergic allergic to penicillin are approximately 4 times Angioedema [9]
to penicillin develop reactions to cephalosporins). more likely to develop an allergic reaction to a Bacterial infection (<2%)
cephalosporin than those people who have no Candidiasis (<2%)
penicillin allergy (from 5–16% of patients allergic Dermatitis (<2%) [2]
Skin to penicillin develop reactions to cephalosporins). Diaphoresis (<2%)
AGEP [4] Edema (<2%) [5]
Anaphylactoid reactions/Anaphylaxis [15] Erythema [2]
Angioedema [3] Skin
AGEP [2] Erythema multiforme [3]
Candidiasis (5%) [3] Exanthems (<2%) [7]
Dermatitis [2] Anaphylactoid reactions/Anaphylaxis [7]
Exanthems [2] Facial edema (<2%)
DRESS syndrome [2] Fixed eruption [2]
Erythroderma [2] Hypersensitivity [4]
Serum sickness-like reaction [2] Herpes simplex (<2%)
Exanthems [7] Herpes zoster (<2%)
Hypersensitivity [4] Toxic epidermal necrolysis [2]
Urticaria [2] Hot flashes (<2%)
Linear IgA bullous dermatosis [2] Hypersensitivity [8]
Pruritus [2] Cardiovascular Nodular eruption (<2%)
Rash (2%) [5] Thrombophlebitis (<10%) Peripheral edema (2%) [2]
Serum sickness-like reaction [2] Gastrointestinal/Hepatic Photosensitivity (<2%)
Urticaria [4] Nausea [2] Pruritus (<2%) [6]
Mucosal Ocular Rash (2%) [11]
Glossitis [2] Stevens-Johnson syndrome [2]
Ocular toxicity [2]
Cardiovascular Sweet’s syndrome [3]
Other Toxic epidermal necrolysis [5]
Flushing [2] Kounis syndrome [3]
Hypotension [2] Urticaria (<2%) [11]
Phlebitis [2] Vasculitis [4]
Xerosis (<2%)
Central Nervous System CELECOXIB
Fever [2]
Hair
Alopecia (<2%) [3]
Gastrointestinal/Hepatic Trade name: Celebrex (Pfizer)
Cholelithiasis (gallstones) [4] Indications: Osteoarthritis, rheumatoid arthritis
Nails
Diarrhea [6] (adults and juveniles aged 2 years and over),
Nail changes (<2%)
Hepatotoxicity [7] ankylosing spondylitis, acute pain, primary Mucosal
Nausea [4] dysmenorrhea Stomatitis (<2%) [4]
Vomiting [2] Class: COX-2 inhibitor, Non-steroidal anti- Xerostomia (<2%)
Respiratory inflammatory (NSAID), Sulfonamide Cardiovascular
Dyspnea [2] Half-life: 11 hours Cardiotoxicity [2]
Clinically important, potentially hazardous Hypertension [2]
Renal interactions with: ACE inhibitors, aliskiren,
Biliary pseudolithiasis [7] Myocardial infarction [4]
angiotensin II receptor antagonists, aspirin,
Nephrolithiasis [2] dexibuprofen, fluconazole, furosemide, lithium, Central Nervous System
Nephrotoxicity [6] NSAIDs, warfarin Anorexia [3]
Renal failure [3] Pregnancy category: D (pregnancy category C Depression [2]
Hematologic prior to 30 weeks gestation; category D starting Dysgeusia (taste perversion) (<2%)
Eosinophilia [2] at 30 weeks gestation) Headache [3]
Hemolysis [9] Important contra-indications noted in the Paresthesias (<2%)
Hemolytic anemia [15] prescribing guidelines for: the elderly; nursing Stroke [3]
Thrombocytopenia [4] mothers; pediatric patients Vertigo (dizziness) [3]
Local Note: Celecoxib is a sulfonamide and can be Neuromuscular/Skeletal
Injection-site pain (<10%) [3] absorbed systemically. Sulfonamides can produce Asthenia (fatigue) [6]
Injection-site phlebitis [2] severe, possibly fatal, reactions such as toxic Myalgia/Myopathy (<2%)
CELECOXIB See all our books at www.crcpress.com
Tendinopathy/Tendon rupture (<2%)

CEPHALEXIN CERTOLIZUMAB
Abdominal pain [10] Synonym: cefalexin Trade name: Cimzia (Celltech) (UCB)
Constipation [5] Trade names: Keflex (Advancis), Keftab (Biovail) Indications: Crohn’s disease, rheumatoid
Diarrhea [11] Indications: Various infections caused by arthritis
Dyspepsia [10] susceptible organisms Class: Disease-modifying antirheumatic drug
Flatulence [2] Class: Cephalosporin, 1st generation (DMARD), Monoclonal antibody, TNF inhibitor
Gastrointestinal bleeding [4] Half-life: 0.91.2 hours Half-life: 14 days
Hepatotoxicity [3] Clinically important, potentially hazardous Clinically important, potentially hazardous
Nausea [14] interactions with: amikacin, gentamicin, interactions with: abatacept, anakinra,
Vomiting [9] metformin lenalidomide, live vaccines, natalizumab,
Endocrine/Metabolic Pregnancy category: B rituximab
Dehydration [2] Important contra-indications noted in the Pregnancy category: N/A (Limited evidence
Mastodynia (<2%) prescribing guidelines for: the elderly; nursing insufficient to inform drug-associated risk)
Genitourinary mothers Important contra-indications noted in the
Vaginitis (<2%) Note: Penicillin and cephalosporins share a prescribing guidelines for: nursing mothers;
Vulvovaginal candidiasis (<2%) common beta-lactam structure. People who are pediatric patients
allergic to penicillin are approximately 4 times Note: TNF inhibitors should be used in patients
Renal more likely to develop an allergic reaction to a with heart failure only after consideration of other
Nephrotoxicity [4] cephalosporin than those people who have no treatment options. TNF inhibitors are contra-
Hematologic penicillin allergy (from 5–16% of patients allergic indicated in patients with a personal or family
Anemia [2] to penicillin develop reactions to cephalosporins). history of multiple sclerosis or demyelinating
Neutropenia [4] disease. TNF inhibitors should not be
Ocular Skin administered to patients with moderate to severe
Visual disturbances [3] AGEP [4] heart failure (New York Heart Association
Anaphylactoid reactions/Anaphylaxis [4] Functional Class III/IV).
Local Warning: SERIOUS INFECTIONS AND
Application-site cellulitis (<2%) Angioedema [2]
Bullous pemphigoid [2] MALIGNANCY
Application-site reactions (<2%)
Erythema multiforme [3]
Other Exanthems [3] Skin
Adverse effects [16] Pemphigus [2] Herpes zoster [3]
Allergic reactions (<2%) [2] Pruritus [3] Neoplasms [2]
Death [4] Pustules [2] Psoriasis [6]
Infection (<2%) Stevens-Johnson syndrome [3] Rash [2]
Tooth disorder (<2%) Toxic epidermal necrolysis [4] Cardiovascular
Urticaria [2] Hypertension [2]
Other Central Nervous System
CELIPROLOL Adverse effects [2] Fever (5%) [2]
Side effects (2%) [2] Headache (7–18%) [5]
Trade names: Celectol (Winthrop), Celol
(Pacific), Selectol (Sanofi-Aventis) Vertigo (dizziness) (~6%)
Indications: Hypertension, angina pectoris Neuromuscular/Skeletal
Class: Beta blocker CEPHALOTHIN Arthralgia (6–7%) [4]
Half-life: 56 hours Back pain [3]
Clinically important, potentially hazardous See: www.drugeruptiondata.com/drug/id/129
interactions with: amiodarone, bepridil, Nausea [2]
diltiazem, disopyramide, floctafenine, quinidine,
theophylline, verapamil CEPHAPIRIN Respiratory
Nasopharyngitis (4–13%) [8]
Pregnancy category: N/A
Important contra-indications noted in the See: www.drugeruptiondata.com/drug/id/130 Pneumonia [2]
prescribing guidelines for: nursing mothers Pulmonary toxicity [4]
Sinusitis [2]
Upper respiratory tract infection (20%) [11]
Central Nervous System CEPHRADINE Endocrine/Metabolic
Headache [2]
Vertigo (dizziness) [2] See: www.drugeruptiondata.com/drug/id/131 Creatine phosphokinase increased [2]
Neuromuscular/Skeletal Genitourinary
Asthenia (fatigue) [3] Urinary tract infection (~8%) [8]
CERITINIB Local
See: www.drugeruptiondata.com/drug/id/3527 Injection-site reactions (~7%) [4]
Other
Death [2]
Infection (14–38%) [14]
Litt’s Drug Eruption & Reaction Manual CETUXIMAB
Mucosal
CETIRIZINE CETRORELIX Mucositis [10]
Oral mucositis [2]
Trade name: Zyrtec (Pfizer) Trade name: Cetrotide (Merck) Stomatitis (25%) [3]
Indications: Allergic rhinitis, urticaria Indications: Inhibition of premature luteinizing Xerostomia (11%)
Class: Histamine H1 receptor antagonist hormone surges in women undergoing controlled
Half-life: 811 hours ovarian stimulation Cardiovascular
Clinically important, potentially hazardous Class: Gonadotropin-releasing hormone (GnRH) Cardiotoxicity [2]
interactions with: alcohol, CNS depressants, antagonist Flushing [2]
pilsicainide Half-life: 5 hours Thromboembolism [2]
Pregnancy category: B Clinically important, potentially hazardous Central Nervous System
Important contra-indications noted in the interactions with: none known Anorexia [2]
prescribing guidelines for: nursing mothers Pregnancy category: X Anxiety (14%)
Important contra-indications noted in the Aseptic meningitis [6]
Skin prescribing guidelines for: nursing mothers Chills (13%) [2]
Acneform eruption (<2%) Confusion (15%)
Anaphylactoid reactions/Anaphylaxis (<2%) Skin Depression (13%)
[2] Hot flashes [2] Fever (30%) [4]
Angioedema (<2%) Headache (33%)
Central Nervous System Insomnia (30%)
Bullous dermatitis (<2%) Headache [2]
Dermatitis (<2%) Pain (51%)
Diaphoresis (<2%) Peripheral neuropathy [3]
Exanthems (<2%) Rigors (13%)
Fixed eruption [6] CETUXIMAB Seizures [2]
Furunculosis (<2%) Neuromuscular/Skeletal
Hyperkeratosis (<2%) Trade name: Erbitux (Bristol-Myers Squibb) Asthenia (fatigue) (89%) [24]
Photosensitivity (<2%) Indications: Metastatic colorectal cancer, Back pain (11%)
Phototoxicity (<2%) squamous cell carcinoma of the head and neck Bone or joint pain (15%)
Pruritus (<2%) Class: Antineoplastic, Biologic, Epidermal growth
factor receptor (EGFR) inhibitor, Monoclonal Gastrointestinal/Hepatic
Purpura (<2%) Abdominal pain (59%)
Rash (<2%) antibody
Half-life: 75188 hours Constipation (46%)
Seborrhea (<2%) Diarrhea (39%) [19]
Urticaria (<2%) [9] Clinically important, potentially hazardous
interactions with: none known Dysphagia [2]
Xerosis (<2%) Hepatotoxicity [4]
Hair Important contra-indications noted in the Nausea [11]
Alopecia (<2%) prescribing guidelines for: nursing mothers; Vomiting (37%) [7]
Hypertrichosis (<2%) pediatric patients Respiratory
Mucosal Warning: SERIOUS INFUSION REACTIONS Cough (29%)
Sialorrhea (<2%) and CARDIOPULMONARY ARREST Dyspnea (48%) [5]
Stomatitis (<2%) Pneumonia [2]
Tongue edema (<2%) Skin Pneumonitis [3]
Tongue pigmentation (<2%) Acneform eruption (88%) [62] Pulmonary toxicity [6]
Xerostomia (6%) [2] Anaphylactoid reactions/Anaphylaxis [5] Endocrine/Metabolic
Cardiovascular Dermatitis [4] Hypokalemia [6]
Flushing (<2%) Desquamation (89%) [3] Hypomagnesemia [16]
QT prolongation [2] Erythema [3] Hyponatremia [5]
Central Nervous System Exanthems [5] Hematologic
Ageusia (taste loss) (<2%) Fissures [4] Anemia [6]
Dysgeusia (taste perversion) (<2%) Folliculitis [13] Febrile neutropenia [5]
Headache [2] Hand–foot syndrome [5] Leukopenia [9]
Hyperesthesia (<2%) Hypersensitivity [8] Neutropenia [22]
Insomnia [2] Papulopustular eruption [7] Sepsis (<4%)
Paresthesias (<2%) Peripheral edema (10%) Thrombocytopenia [5]
Parosmia (<2%) Pruritus (40%) [9] Thrombosis [3]
Somnolence (drowsiness) [5] Radiation recall dermatitis [2]
Rash (89%) [47] Ocular
Neuromuscular/Skeletal Toxic epidermal necrolysis [2] Blepharitis [3]
Asthenia (fatigue) [3] Toxicity [18] Conjunctivitis (7%) [2]
Dystonia [6] Xerosis (49%) [14] Ectropion [2]
Myalgia/Myopathy (<2%) Eyelashes – hypertrichosis [3]
Hair Trichomegaly [11]
Endocrine/Metabolic Abnormal hair growth [2]
Mastodynia (<2%) Alopecia (5%) Local
Genitourinary Hair changes [3] Application-site reactions (~3%)
Vaginitis (<2%) Hypertrichosis [3] Infusion-related reactions [7]
Infusion-site reactions (15–21%) [10]
Other Nails
Adverse effects [4] Nail changes (21%) Other
Nail disorder [2] Adverse effects [8]
Paronychia [15] Allergic reactions [3]
CETUXIMAB Over 100 updates per week on www.drugeruptiondata.com
Death [6] Gastroesophageal reflux (<3%) Sedation (prolonged) [2]

Infection (13–35%) [3] Nausea (14%) [3] Gastrointestinal/Hepatic
Vomiting (5%) Vomiting [4]
Respiratory Respiratory
CEVIMELINE Bronchitis (4%) Apnea [2]
Cough (6%)
Trade name: Evoxac (Daiichi Sankyo) Flu-like syndrome (<3%) Other
Indications: Sicca syndrome in patients with Pharyngitis (5%) Adverse effects [3]
Sjøgren’s syndrome Pneumonia (<3%) Death [3]
Class: Muscarinic cholinergic agonist Rhinitis (11%)
Half-life: 34 hours Sinusitis (12%)
Clinically important, potentially hazardous Upper respiratory tract infection (11%) CHLORAMBUCIL
interactions with: none known Genitourinary
Pregnancy category: C Urinary tract infection (6%) See: www.drugeruptiondata.com/drug/id/136
Important contra-indications noted in the Vaginitis (<3%)
pediatric patients Hematologic
Note: Contra-indicated in patients with Anemia (<3%) CHLORAMPHENICOL
uncontrolled asthma, acute iritis or narrow-angle Otic Indications: Various infections caused by
glaucoma. Ear pain (<3%) susceptible organisms
Otitis media (<3%) Class: Antibiotic, CYP3A4 inhibitor
Skin Ocular Half-life: 1.53.5 hours
Abscess (<3%) Abnormal vision (<3%) Clinically important, potentially hazardous
Candidiasis (<3%) Conjunctivitis (4%) interactions with: amoxicillin, ampicillin,
Diaphoresis (20%) Ocular pain (<3%) clopidogrel, clozapine, ethotoin, fosphenytoin,
Edema (<3%) Xerophthalmia (<3%) gliclazide, levodopa, mephenytoin, phenytoin,
Erythema (<3%) Other propyphenazone, voriconazole
Exanthems (<10%) Allergic reactions (<3%) Pregnancy category: C
Fungal dermatitis (<10%) Infection (<3%) Important contra-indications noted in the
Hot flashes (2%) Tooth disorder (<3%) prescribing guidelines for: nursing mothers
Hyperhidrosis (19%) [5]
Peripheral edema (<3%) Skin
Pruritus (<3%) AGEP [2]
Rash (4%) CHARCOAL Dermatitis [18]
Mucosal See: www.drugeruptiondata.com/drug/id/1158 Erythema multiforme [6]
Epistaxis (nosebleed) (<3%) Exanthems (<5%) [5]
Sialadenitis (<3%) Hypersensitivity [2]
Sialorrhea (2%) Purpura [2]
Ulcerative stomatitis (<3%) CHLORAL HYDRATE Pustules [2]
Xerostomia (<3%) Sensitization [2]
Indications: Insomnia, sedation Toxic epidermal necrolysis [2]
Cardiovascular Class: Anesthetic, general, Hypnotic
Chest pain (<3%) Urticaria [3]
Palpitation (<3%) Clinically important, potentially hazardous Nails
Central Nervous System interactions with: antihistamines, azatadine, Photo-onycholysis [2]
Anorexia (<3%) brompheniramine, buclizine, chlorpheniramine,
Depression (<3%) clemastine, dexchlorpheniramine,
Fever (<3%) diphenhydramine, meclizine, tripelennamine CHLORDIAZEPOXIDE
Headache (14%) Pregnancy category: C
Hypoesthesia (<3%) Important contra-indications noted in the Trade names: Libritabs (Valeant), Librium
Hyporeflexia (<3%) prescribing guidelines for: nursing mothers (Valeant), Limbitrol (Valeant)
Insomnia (2%) Indications: Anxiety
Migraine (<3%) Skin Class: Benzodiazepine
Pain (3%) Acneform eruption [2] Half-life: 625 hours
Tremor (<3%) Angioedema [2] Clinically important, potentially hazardous
Vertigo (dizziness) (4%) Dermatitis [2] interactions with: chlorpheniramine,
Neuromuscular/Skeletal Erythema multiforme [2] clarithromycin, efavirenz, esomeprazole, imatinib,
Arthralgia (4%) Exanthems [3] indinavir, ketoconazole, nelfinavir, nilutamide,
Back pain (5%) Fixed eruption [5] ritonavir
Bone or joint pain (3%) Pruritus [2] Pregnancy category: D
Hypertonia (<3%) Purpura [2] Important contra-indications noted in the
Leg cramps (<3%) Rash (<10%) prescribing guidelines for: the elderly; nursing
Myalgia/Myopathy (<3%) Urticaria (<10%) [2] mothers; pediatric patients
Note: Limbitrol is chlordiazepoxide and
Gastrointestinal/Hepatic Mucosal amitriptyline.
Abdominal pain (8%) Oral lesions [2]
Constipation (<3%) Cardiovascular
Diarrhea (10%) Skin
Hypotension [2] Angioedema [3]
Dyspepsia (8%)
Eructation (belching) (<3%) Central Nervous System Dermatitis (<10%)
Agitation [2] Diaphoresis (>10%)
Litt’s Drug Eruption & Reaction Manual CHLORPHENIRAMINE
Edema (<10%) Gastrointestinal/Hepatic

Erythema multiforme [5] CHLOROQUINE Diarrhea [2]
Erythema nodosum [2] Nausea [3]
Exanthems [3] Trade name: Aralen (Sanofi-Aventis) Vomiting [5]
Fixed eruption [7] Indications: Malaria, rheumatoid arthritis, lupus
erythematosus Endocrine/Metabolic
Lupus erythematosus [3] Porphyria [7]
Photosensitivity [6] Class: Antimalarial, Antiprotozoal, Disease-
Purpura [5] modifying antirheumatic drug (DMARD) Ocular
Rash (>10%) Half-life: 35 days Corneal deposits [2]
Urticaria [4] Clinically important, potentially hazardous Keratopathy [2]
Vasculitis [2] interactions with: acitretin, antacids, arsenic, Maculopathy [3]
cholera vaccine, cholestyramine, citalopram, Ocular adverse effects [2]
Hair dapsone, dasatinib, degarelix, droperidol, Ocular toxicity [4]
Alopecia [3] ethosuximide, furazolidone, halofantrine, Retinopathy [10]
Mucosal hydroxychloroquine, lacosamide, lanthanum, Vision blurred [2]
Sialopenia (>10%) lapatinib, levofloxacin, methotrexate, Other
Sialorrhea (<10%) methoxsalen, mivacurium, moxifloxacin, Adverse effects [2]
Xerostomia (>10%) neostigmine, nilotinib, oxcarbazepine, pazopanib, Death [3]
Endocrine/Metabolic penicillamine, ribociclib, sulfonamides, telavancin,
Galactorrhea [3] telithromycin, tiagabine, typhoid vaccine,
vandetanib, vigabatrin, voriconazole, vorinostat,
ziprasidone CHLOROTHIAZIDE
CHLORHEXIDINE Important contra-indications noted in the See: www.drugeruptiondata.com/drug/id/142
Trade name: Hibiclens (SSL)
Indications: Skin antisepsis, gingivitis
Class: Antiseptic Skin CHLOROTRIANISENE
Half-life: N/A Dermatitis [2]
Erythema annulare centrifugum [2] See: www.drugeruptiondata.com/drug/id/143
interactions with: none known Erythroderma [3]
Pregnancy category: B Exanthems (<5%) [3]
Important contra-indications noted in the Exfoliative dermatitis [4] CHLORPHENIRAMINE
prescribing guidelines for: nursing mothers; Lichenoid eruption [6]
pediatric patients Photosensitivity [8] Synonym: chlorphenamine
Pigmentation [15] Trade names: Chlor-Trimeton (Schering),
Pruritus [36] Triaminic (Novartis)
Skin Psoriasis [18] Indications: Allergic rhinitis, urticaria
Anaphylactoid reactions/Anaphylaxis [29] Stevens-Johnson syndrome [4] Class: Histamine H1 receptor antagonist,
Dermatitis [16] Toxic epidermal necrolysis [5] Muscarinic antagonist
Hypersensitivity [9] Toxicity [2] Half-life: 2040 hours
Rash [2] Urticaria [4] Clinically important, potentially hazardous
Urticaria [4] Vitiligo [7] interactions with: alcohol, anticholinergics,
Mucosal Hair barbiturates, benzodiazepines, butabarbital,
Gingival pigmentation [2] Hair pigmentation [10] chloral hydrate, chlordiazepoxide,
Gingivitis [3] Poliosis [3] chlorpromazine, clonazepam, clorazepate,
Glossitis (<10%) diazepam, ethchlorvynol, fluphenazine,
Mucosal ulceration [2] Nails flurazepam, hypnotics, lopinavir, lorazepam, MAO
Oral mucosal irritation [2] Nail pigmentation [2] inhibitors, mephobarbital, mesoridazine,
Stomatitis (<10%) Mucosal midazolam, narcotics, oxazepam, pentobarbital,
Tongue irritation (<10%) Mucosal membrane pigmentation [2] phenobarbital, phenothiazines, phenylbutazone,
Tongue pigmentation (>10%) Oral pigmentation [12] primidone, prochlorperazine, promethazine,
Central Nervous System Cardiovascular quazepam, secobarbital, sedatives, temazepam,
Dysgeusia (taste perversion) (>10%) [7] Atrioventricular block [2] thioridazine, tranquilizers, trifluoperazine,
Cardiac failure [2] zolpidem
Other Pregnancy category: B
Allergic reactions [6] Cardiomyopathy [8]
Cardiotoxicity [3] Important contra-indications noted in the
Tooth pigmentation [4] prescribing guidelines for: the elderly; nursing
Congestive heart failure [2]
Myocardial toxicity [2] mothers; pediatric patients
QT prolongation [3]
CHLORMEZANONE Torsades de pointes [2] Skin
Central Nervous System Angioedema (<10%)
See: www.drugeruptiondata.com/drug/id/140 Dermatitis (<10%) [4]
Headache [4]
Psychosis [4] Photosensitivity (<10%)
Seizures [2] Mucosal
Vertigo (dizziness) [4] Xerostomia (<10%)
Myalgia/Myopathy [8] Seizures [2]
Myasthenia gravis [7]
CHLORPROMAZINE See all our books at www.crcpress.com
Corneal opacity [2] doxercalciferol, ergocalciferol,

CHLORPROMAZINE Eyelid edema [2] hydroxychloroquine, isotretinoin, leflunomide,
Retinopathy [2] levodopa, lovastatin, meloxicam, mycophenolate,
Trade name: Thorazine (GSK) phytonadione, propranolol, raloxifene,
Indications: Psychosis, manic-depressive Other
Adverse effects [3] sulfasalazine, sulfonylureas, tetracycline, tricyclic
disorders antidepressants, troglitazone, ursodiol, valproic
Class: Antiemetic, Antipsychotic, Muscarinic acid, vitamin A, vitamin E
antagonist, Phenothiazine Pregnancy category: C
Half-life: initial: 2 hours; terminal: 30 hours CHLORPROPAMIDE Important contra-indications noted in the
Clinically important, potentially hazardous prescribing guidelines for: nursing mothers;
interactions with: alcohol, antihistamines, See: www.drugeruptiondata.com/drug/id/146 pediatric patients
arsenic, asenapine, chlorpheniramine, dofetilide, Note: Contra-indicated in patients with complete
epinephrine, evening primrose, guanethidine, biliary obstruction.
lisdexamfetamine, mivacurium, pimavanserin,
propranolol, quinolones, sodium picosulfate,
CHLORTETRACYCLINE
sparfloxacin, tetrabenazine, zolpidem Skin
See: www.drugeruptiondata.com/drug/id/147 Pruritus [2]
prescribing guidelines for: the elderly; nursing Osteomalacia [2]
mothers; pediatric patients CHLORTHALIDONE Hematologic
Note: The prolonged use of chlorpromazine can Hemorrhage [2]
produce a gray-blue or purplish pigmentation See: www.drugeruptiondata.com/drug/id/148
over light-exposed areas. This is a result of either
dermal deposits of melanin, a chlorpromazine
metabolite, or to a combination of both. CHLORZOXAZONE CHOLIC ACID
Chlorpromazine melanosis is seen more often in
women. See: www.drugeruptiondata.com/drug/id/149 Trade name: Cholbam (Asklepion
Warning: INCREASED MORTALITY IN Pharmaceuticals)
ELDERLY PATIENTS WITH DEMENTIA- Indications: Bile acid synthesis disorders,
adjunctive treatment of peroxisomal disorders
RELATED PSYCHOSIS CHOLERA VACCINE Class: Bile acid
Half-life: N/A
Skin Trade name: Vaxchora (PaxVax) Clinically important, potentially hazardous
Exanthems (>5%) [8] Indications: Immunization against cholera for interactions with: cyclosporine
Lupus erythematosus [12] adults traveling to cholera-affected areas Pregnancy category: N/A
Photosensitivity (<10%) [22] Class: Vaccine Important contra-indications noted in the
Phototoxicity [6] Half-life: N/A prescribing guidelines for: the elderly; nursing
Pigmentation [16] Clinically important, potentially hazardous mothers
Pruritus (<10%) [2] interactions with: antibiotics, chloroquine
Purpura [6] Pregnancy category: N/A (Not expected to
Rash (<10%) cause fetal risk) Gastrointestinal/Hepatic
Seborrheic dermatitis [4] Important contra-indications noted in the Diarrhea (2%)
Toxic epidermal necrolysis [2] prescribing guidelines for: the elderly; pediatric
Urticaria [4] patients
Vasculitis [3] CHOLINE C11
Nails Central Nervous System
Nail pigmentation [4] Headache (29%) See: www.drugeruptiondata.com/drug/id/3057
Mucosal Neuromuscular/Skeletal
Xerostomia (<10%) Asthenia (fatigue) (31%)
Cardiovascular Gastrointestinal/Hepatic
CHOLINE
Hypotension [4] Abdominal pain (19%) FENOFIBRATE
QT prolongation [4] Diarrhea (4%)
Tachycardia [2] Nausea (18%) See: www.drugeruptiondata.com/drug/id/2095
Torsades de pointes [2] Vomiting (18%)
Central Nervous System Endocrine/Metabolic
Neuroleptic malignant syndrome [7] Appetite decreased (17%) CICLESONIDE
Sedation [3]
Seizures [2] See: www.drugeruptiondata.com/drug/id/1263
Endocrine/Metabolic CHOLESTYRAMINE
Galactorrhea (<10%)
Gynecomastia (<10%) Trade name: Questran (Par) CICLOPIROX
Mastodynia (<10%) Indications: Pruritus associated with biliary
Weight gain [2] obstruction, primary hypercholesterolemia See: www.drugeruptiondata.com/drug/id/2335
Genitourinary Class: Bile acid sequestrant
Half-life: N/A
Priapism [7]
Otic interactions with: acarbose, acetaminophen,
Tinnitus [2] acitretin, amiodarone, aspirin, bezafibrate,
Ocular calcifediol, chloroquine, cyclopenthiazide,
Cataract [2] cyclosporine, deferasirox, digoxin, doxepin,
Litt’s Drug Eruption & Reaction Manual CILOSTAZOL
Anxiety (<2%)
CIDOFOVIR CILOSTAZOL Cerebral ischemia (<2%)
Chills (<2%)
Trade name: Vistide (Gilead) Trade name: Pletal (Otsuka) Headache (27–34%) [19]
Indications: Cytomegalovirus (CMV) retinitis in Indications: Peripheral vascular disease, Hyperesthesia (2%)
patients with acquired immunodeficiency intermittent claudication Insomnia (<2%)
syndrome (AIDS) Class: Antiplatelet, Phosphodiesterase inhibitor, Neurotoxicity (<2%)
Class: Antiviral, nucleotide analog Vasodilator, peripheral Paresthesias (2%)
Half-life: ~2.6 hours Half-life: 1113 hours Syncope (<2%)
Clinically important, potentially hazardous Clinically important, potentially hazardous Vertigo (dizziness) (<10%) [4]
interactions with: amphotericin B, cobicistat/ interactions with: anagrelide, anticoagulants,
elvitegravir/emtricitabine/tenofovir alafenamide, antifungals, antiplatelet agents, clarithromycin, Neuromuscular/Skeletal
cobicistat/elvitegravir/emtricitabine/tenofovir collagenase, conivaptan, CYP2C19 inhibitors, Arthralgia (<2%)
disoproxil, tenofovir disoproxil CYP3A4 inhibitors and inducers, dasatinib, Asthenia (fatigue) (<2%)
Pregnancy category: C deferasirox, diltiazem, drotrecogin alfa, Back pain (6–7%)
Important contra-indications noted in the erythromycin, esomeprazole, fondaparinux, Bone or joint pain (<2%)
prescribing guidelines for: the elderly; nursing glucosamine, grapefruit juice, high-fat foods, Gouty tophi (<2%)
mothers; pediatric patients ibritumomab, itraconazole, ketoconazole, Myalgia/Myopathy (23%)
Warning: RENAL TOXICITY and macrolide antibiotics, NSAIDs, omeprazole, PEG- Gastrointestinal/Hepatic
NEUTROPENIA interferon, pentosan, pentoxifylline, prostacyclin Abdominal pain (4–5%)
analogues, salicylates, St John’s wort, Black stools (<2%)
Skin telithromycin, thrombolytic agents, tositumomab Cholelithiasis (gallstones) (<2%)
Acneform eruption (>10%) & iodine131, voriconazole Colitis (<2%)
Diaphoresis (<10%) Pregnancy category: C Diarrhea (12–19%) [7]
DRESS syndrome [2] Important contra-indications noted in the Dyspepsia (6%)
Pallor (<10%) prescribing guidelines for: nursing mothers; Esophagitis (<2%)
Pigmentation (>10%) pediatric patients Flatulence (2–3%)
Pruritus (<10%) [2] Note: Contra-indicated in patients with Gastritis (<2%)
Rash (27%) [2] congestive heart failure or active pathological Gastroenteritis (<2%)
Toxicity [3] bleeding. Gastrointestinal ulceration (<2%)
Ulcerations [2] Warning: CONTRA-INDICATED IN HEART Hematemesis (<2%)
Urticaria (<10%) FAILURE PATIENTS Nausea (6–7%) [4]
Peptic ulceration (<2%)
Hair Vomiting (>2%)
Alopecia (22%) [2] Skin
Ecchymoses (<2%) Respiratory
Mucosal Edema (<2%) Asthma (<2%)
Stomatitis (<10%) Facial edema (<2%) Cough (3–4%) [2]
Central Nervous System Furunculosis (<2%) Hemoptysis (<2%)
Chills (24%) Hypertrophy (<2%) Pharyngitis (7–10%)
Dysgeusia (taste perversion) (<10%) Peripheral edema (79%) Pneumonia (<2%)
Headache [4] Purpura (<2%) Rhinitis (7–12%)
Paresthesias (>10%) Rash (2%) [2] Sinusitis (<2%)
Neuromuscular/Skeletal Urticaria (<2%) Endocrine/Metabolic
Asthenia (fatigue) [2] Varicosities (<2%) Creatine phosphokinase increased (<2%)
Myalgia/Myopathy [2] Xerosis (<2%) Diabetes mellitus (<2%)
Renal Mucosal GGT increased (<2%)
Fanconi syndrome [2] Epistaxis (nosebleed) (<2%) Hyperlipidemia (<2%)
Nephrotoxicity [5] Gingival bleeding (<2%) Hyperuricemia (<2%)
Perioral abscess (<2%) Genitourinary
Ocular Rectal hemorrhage (<2%)
Intraocular inflammation [2] Albuminuria (<2%)
Tongue edema (<2%) Cystitis (<2%)
Iritis [6]
Ocular hypotension [2] Cardiovascular Urinary frequency (<2%)
Retinal detachment [3] Arrhythmias (<2%) Vaginal bleeding (<2%)
Uveitis [18] Atrial fibrillation (<2%) Vaginitis (<2%)
Vision impaired [3] Atrial flutter (<2%) Renal
Vision loss [3] Cardiac arrest (<2%) Retroperitoneal bleeding (<2%)
Cardiotoxicity [4]
Local Congestive heart failure (<2%) Hematologic
Application-site reactions (39%) [3] Extrasystoles (<2%) Anemia (<2%)
Other Hypotension (<2%) Hemorrhage (<2%)
Allergic reactions (<10%) Myocardial infarction (<2%) [4] Polycythemia (<2%)
Myocardial ischemia (<2%) Thrombosis [3]
Palpitation (5–10%) [7] Otic
Postural hypotension (<2%) Ear pain (<2%)
CILAZAPRIL Supraventricular tachycardia (<2%) Tinnitus (<2%)
Tachycardia (4%) [4] Ocular
Vasodilation (<2%) Amblyopia (<2%)
Ventricular tachycardia (<2%) Blindness (<2%)
Central Nervous System Conjunctivitis (<2%)
Anorexia (<2%) Diplopia (<2%)
CILOSTAZOL Over 100 updates per week on www.drugeruptiondata.com
Ocular hemorrhage (<2%) Renal taking corticosteroid drugs, and in patients with
Other Nephrotoxicity [3] kidney, heart or lung transplants.
Adverse effects [4] Fluoroquinolones may exacerbate muscle
Death [3] weakness in persons with myasthenia gravis.
Ciprofloxacin is chemically related to nalidixic
Infection (10–14%) CINACALCET acid.
See: www.drugeruptiondata.com/drug/id/1021 Warning: SERIOUS ADVERSE REACTIONS
INCLUDING TENDINITIS, TENDON
CIMETIDINE RUPTURE, PERIPHERAL NEUROPATHY,
CENTRIAL NERVOUS SYSTEM EFFECTS and
Trade name: Tagamet (GSK) CINNARIZINE EXACERBATION OF MYASTHENIA GRAVIS
Indications: Duodenal ulcer
Class: CYP1A2 inhibitor, CYP3A4 inhibitor, See: www.drugeruptiondata.com/drug/id/1076
Histamine H2 receptor antagonist Skin
Half-life: 2 hours Acneform eruption [3]
Clinically important, potentially hazardous AGEP [4]
interactions with: acenocoumarol, alfuzosin,
CINOXACIN Anaphylactoid reactions/Anaphylaxis [15]
aminophylline, amiodarone, amitriptyline, Angioedema [8]
See: www.drugeruptiondata.com/drug/id/154 Candidiasis [2]
anisindione, anticoagulants, buprenorphine,
butorphanol, caffeine, carmustine, citalopram, Diaphoresis [5]
clobazam, clopidogrel, clozapine, cocoa, Erythema multiforme [5]
delavirdine, dicumarol, dofetilide, duloxetine, CIPROFIBRATE Exanthems [4]
dutasteride, epirubicin, eszopiclone, fentanyl, Facial edema [2]
ferrous sulfate, floxuridine, fluorouracil, See: www.drugeruptiondata.com/drug/id/1140 Fixed eruption [13]
galantamine, gliclazide, hydromorphone, Hypersensitivity [5]
itraconazole, ketoconazole, labetalol, Jaundice [2]
levomepromazine, lidocaine, lomustine, CIPROFLOXACIN Linear IgA bullous dermatosis [2]
meptazinol, metformin, metronidazole, Photosensitivity [19]
midazolam, mizolastine, moclobemide, Trade names: Ciloxan Ophthalmic (Alcon), Phototoxicity [5]
morphine, narcotic analgesics, neratinib, Cipro (Bayer), Ciproxin (Bayer) Pruritus [11]
oxprenolol, oxtriphylline, oxycodone, Indications: Various infections caused by Purpura [4]
oxymorphone, pentazocine, phenytoin, susceptible organisms, inhalational anthrax (post Rash (<10%) [13]
pimecrolimus, posaconazole, prednisone, exposure) Serum sickness-like reaction [3]
propranolol, quinine, rilpivirine, risperidone, Class: Antibiotic, fluoroquinolone, CYP1A2 Stevens-Johnson syndrome [9]
roflumilast, sertindole, sildenafil, sufentanil, inhibitor, CYP3A4 inhibitor Toxic epidermal necrolysis [11]
tamsulosin, terbinafine, thalidomide, tolazoline, Half-life: 4 hours Toxicity [3]
warfarin, xanthines, zaleplon, zofenopril, Clinically important, potentially hazardous Urticaria [9]
zolmitriptan, zolpidem interactions with: agomelatine, aminophylline, Vasculitis [11]
Pregnancy category: B amiodarone, amitriptyline, antacids, Mucosal
Important contra-indications noted in the antineoplastics, arsenic, artemether/lumefantrine, Stomatitis [4]
prescribing guidelines for: nursing mothers; BCG vaccine, bendamustine, bepridil, bismuth, Xerostomia [3]
pediatric patients bismuth subsalicylate, bretylium, calcium salts, Cardiovascular
citalopram, clopidogrel, clozapine, Palpitation [2]
Skin corticosteroids, cyclosporine, dairy products, QT prolongation [11]
Angioedema [3] dasatinib, degarelix, didanosine, disopyramide, Torsades de pointes [8]
Erythema annulare centrifugum [2] dolasetron, duloxetine, dutasteride, eluxadoline,
erlotinib, erythromycin, flibanserin, insulin, Central Nervous System
Erythema multiforme [5] Dysgeusia (taste perversion) [3]
Exanthems [3] lanthanum, lapatinib, levofloxacin, magnesium
salts, meptazinol, methotrexate, methylxanthines, Fever [3]
Exfoliative dermatitis [2] Headache [6]
Fixed eruption [2] mifepristone, moxifloxacin, mycophenolate,
neratinib, NSAIDs, olanzapine, olaparib, opiod Mania [4]
Hypersensitivity [4] Peripheral neuropathy [2]
Lupus erythematosus [3] analgesics, oral iron, oxtriphylline, P-glycoprotein
inhibitors, pazopanib, pentoxifylline, Psychosis [5]
Pruritus [6] Seizures [5]
Pseudolymphoma [2] phenothiazines, phenytoin, pirfenidone,
probenecid, procainamide, propranolol, QT Syncope [2]
Psoriasis [6] Tremor [2]
Rash (<2%) prolonging agents, quinapril, quinidine, rasagiline,
ropinirole, ropivacaine, sevelamer, sotalol, St Vertigo (dizziness) [2]
Toxic epidermal necrolysis [2] John’s wort, strontium ranelate, sucralfate, Neuromuscular/Skeletal
Urticaria [6] sulfonylureas, telavancin, telithromycin, tizanidine, Arthralgia [2]
Vasculitis [3] tricyclic antidepressants, typhoid vaccine, Asthenia (fatigue) [3]
venetoclax, vitamin K antagonists, voriconazole, Myalgia/Myopathy [2]
Hair vorinostat, warfarin, zinc, ziprasidone, Myasthenia gravis (exacerbation) [2]
Alopecia [4] zolmitriptan Myoclonus [4]
Central Nervous System Pregnancy category: C Rhabdomyolysis [4]
Hallucinations [3] Important contra-indications noted in the Tendinitis [4]
Neuromuscular/Skeletal prescribing guidelines for: the elderly; nursing Tendinopathy/Tendon rupture [31]
Myalgia/Myopathy [2] mothers Gastrointestinal/Hepatic
Note: Fluoroquinolones are associated with an Abdominal pain [2]
Endocrine/Metabolic increased risk of tendinitis and tendon rupture in
Gynecomastia [12] Constipation [2]
all ages. This risk is further increased in older Flatulence [2]
patients usually over 60 years of age, in patients Hepatitis [4]
Litt’s Drug Eruption & Reaction Manual CITALOPRAM
Hepatotoxicity [7] Hair Febrile neutropenia [36]

Nausea (3%) [4] Alopecia (>10%) [24] Hemolytic uremic syndrome [12]
Pancreatitis [2] Mucosal Hemotoxicity [3]
Vomiting [2] Epistaxis (nosebleed) [3] Leukopenia [30]
Genitourinary Mucositis [16] Lymphopenia [5]
Vaginitis [2] Oral lesions [2] Myelosuppression [7]
Stomatitis [16] Myelotoxicity [3]
Renal Neutropenia [88]
Nephrotoxicity [9] Cardiovascular Thrombocytopenia [48]
Renal failure [3] Cardiotoxicity [2] Thrombosis [2]
Hematologic Flushing [5]
Hypertension [7] Otic
Bone marrow suppression [2] Hearing loss [14]
Hemolytic anemia [2] Thromboembolism [6]
Venous thromboembolism [4] Ototoxicity [39]
Thrombocytopenia [4] Tinnitus [27]
Otic Central Nervous System
Anorexia [23] Local
Hearing loss [2] Injection-site cellulitis [4]
Ocular Fever [5] Other
Hallucinations, visual [6] Headache [4] Adverse effects [15]
Vision blurred [2] Insomnia [4] Death [16]
Local Leukoencephalopathy [10] Hiccups [6]
Injection-site pain [2] Neurotoxicity [14] Infection [9]
Other Pain [3]
Adverse effects [8] Peripheral neuropathy [8]
Death [4] Seizures [4]
CITALOPRAM
Neuromuscular/Skeletal Trade names: Celexa (Forest), Cipramil
(Lundbeck)
CISATRACURIUM Asthenia (fatigue) [34]
Ataxia [2] Indications: Depression, obsessive-compulsive
See: www.drugeruptiondata.com/drug/id/897 Myalgia/Myopathy [3] disorder, panic disorder
Gastrointestinal/Hepatic Class: Antidepressant, Selective serotonin
reuptake inhibitor (SSRI)
Abdominal pain [4]
Half-life: ~35 hours
CISPLATIN Constipation [4]
Diarrhea [34] Clinically important, potentially hazardous
interactions with: alcohol, alfuzosin, alpha or
Synonym: CDDP Esophagitis [2]
beta blockers, antidepressants, antiepileptics,
Trade name: Platinol (Bristol-Myers Squibb) Gastrointestinal bleeding [2]
antiplatelet agents, artemether/lumefantrine,
Indications: Carcinomas, lymphomas Hepatotoxicity [6]
aspirin, atomoxetine, barbiturates, bupropion,
Class: Alkylating agent, Antineoplastic Nausea [48]
buspirone, carbamazepine, chloroquine,
Half-life: alpha phase: 25–49 minutes; beta phase: Pancreatitis [2]
cimetidine, ciprofloxacin, clozapine, CNS
58–73 hours Vomiting [35]
depressants, collagenase, conivaptan, coumarins/
Clinically important, potentially hazardous Respiratory anticoagulants, CYP2C19 inhibitors, CYP3A4
interactions with: aldesleukin, atenolol, Cough [4] inhibitors, cyproheptadine, desmopressin,
chlorothiazide, gadobenate, methotrexate, Dysphonia [4] dexibuprofen, dextromethorphan, dronedarone,
paclitaxel, pentamidine, rituximab, selenium, Dyspnea [4] drotrecogin alfa, duloxetine, efavirenz,
thalidomide, zinc Pneumonia [4] fluconazole, gadobutrol, glucosamine,
Pregnancy category: D Pneumonitis [3] haloperidol, ibritumomab, iobenguane,
Important contra-indications noted in the Pulmonary toxicity [5] isocarboxazid, lithium, macrolide antibiotics,
prescribing guidelines for: the elderly; nursing Endocrine/Metabolic MAO inhibitors, methadone, methylphenidate,
mothers ALP increased [2] metoclopramide, mexiletine, moclobemide,
ALT increased [5] nilotinib, NSAIDs, opioid anagesics, pentoxifylline,
Skin Appetite decreased [7] phenelzine, phenytoin, pimozide, QT prolonging
Acneform eruption [6] AST increased [5] agents, quinine, rasagiline, risperidone, ritonavir,
Anaphylactoid reactions/Anaphylaxis [10] Dehydration [3] salicylates, selegiline, serotonin modulators,
Angioedema [4] Hyperglycemia [3] sibutramine, SSRIs, St John’s wort, sumatriptan,
Edema [3] Hyperkalemia [2] tetrabenazine, thioridazine, thrombolytic agents,
Erythema [3] Hypocalcemia [2] tositumomab & iodine131, tramadol,
Exanthems [4] Hypokalemia [5] tranylcypromine, trazodone, tricyclic
Hand–foot syndrome [9] Hypomagnesemia [13] antidepressants, tryptophan, vitamin K
Hypersensitivity [5] Hyponatremia [18] antagonists, ziprasidone
Necrosis [2] Serum creatinine increased [8] Pregnancy category: C
Peripheral edema [2] SIADH [18] Important contra-indications noted in the
Pigmentation [5] Weight loss [4] prescribing guidelines for: nursing mothers;
Pruritus [7] pediatric patients
Renal
Rash [21] Warning: SUICIDALITY AND
Nephrotoxicity [65]
Raynaud’s phenomenon [14] ANTIDEPRESSANT DRUGS
Proteinuria [2]
Thrombocytopenic purpura [2] Renal failure [3]
Toxic epidermal necrolysis [2] Renal function abnormal [2] Skin
Toxicity [7] Diaphoresis (11%) [3]
Urticaria [7] Hematologic
Hyperhidrosis (11%) [2]
Anemia [48]
CITALOPRAM See all our books at www.crcpress.com
Pigmentation [2] Other deflazacort, delavirdine, diazepam, digoxin,

Pruritus (<10%) [2] Adverse effects [2] dihydroergotamine, disopyramide, dronedarone,
Rash (<10%) Death [8] efavirenz, eletriptan, eluxadoline, ergot alkaloids,
Mucosal estradiol, etravirine, everolimus, fesoterodine,
Xerostomia (20%) [4] flibanserin, fluoxetine, flurazepam, fluticasone
propionate, fluvastatin, HMG-CoA reductase
Cardiovascular CLADRIBINE inhibitors, ibrutinib, imatinib, indinavir,
Bradycardia [2] itraconazole, ixabepilone, lapatinib, lomitapide,
Cardiotoxicity [4] Trade name: Leustatin (Janssen Biotech)
Indications: Leukemias lopinavir, lorazepam, lovastatin, maraviroc,
Chest pain [2] methylergonovine, methylprednisolone,
Palpitation [2] Class: Antimetabolite, Antineoplastic
Half-life: alpha phase: 25 minutes; beta phase: 7 methysergide, midazolam, midostaurin,
QT prolongation [22] mifepristone, naldemedine, neratinib, nevirapine,
Tachycardia [3] hours
Clinically important, potentially hazardous nilotinib, olaparib, omeprazole, oxazepam,
Torsades de pointes [9] oxtriphylline, paclitaxel, palbociclib, paroxetine
Central Nervous System Pregnancy category: D hydrochloride, pazopanib, pimavanserin,
Agitation (3%) Important contra-indications noted in the pimozide, ponatinib, pravastatin, prednisone,
Akathisia [2] prescribing guidelines for: the elderly; nursing quazepam, ranolazine, regorafenib, repaglinide,
Anorexia (4%) mothers ribociclib, rilpivirine, rimonabant, rivaroxaban,
Anxiety (4%) [2] romidepsin, ruxolitinib, sertraline, sildenafil,
Fever (2%) silodosin, simeprevir, simvastatin, solifenacin,
Headache [5] Skin sunitinib, tadalafil, temazepam, temsirolimus,
Incoordination [2] Diaphoresis (<10%) ticagrelor, tipranavir, tolvaptan, trabectedin,
Insomnia (15%) [3] Edema (6%) triazolam, ulipristal, valbenazine, vandetanib,
Nightmares [2] Erythema (6%) vemurafenib, venetoclax, vorapaxar, warfarin,
Restless legs syndrome [4] Exanthems (2750%) [2] zidovudine
Seizures (overdose) [5] Herpes zoster [5] Pregnancy category: C
Serotonin syndrome [19] Petechiae (8%) Important contra-indications noted in the
Somnolence (drowsiness) (18%) [6] Pruritus (6%) prescribing guidelines for: the elderly; nursing
Suicidal ideation [3] Purpura (10%) mothers; pediatric patients
Tremor (8%) [5] Rash (27%) [3]
Vertigo (dizziness) [5] Mucosal Skin
Yawning (2%) Mucositis [2] Anaphylactoid reactions/Anaphylaxis [2]
Neuromuscular/Skeletal Neuromuscular/Skeletal Exanthems [2]
Arthralgia (2%) Myalgia/Myopathy (7%) Fixed eruption [3]
Asthenia (fatigue) (5%) [4] Hematologic Hypersensitivity [3]
Dystonia [2] Psoriasis [2]
Lymphocytopenia [4]
Myalgia/Myopathy (2%) Purpura [3]
Lymphopenia [3]
Gastrointestinal/Hepatic Rash (3%) [2]
Neutropenia [8]
Abdominal pain (3%) Serum sickness-like reaction [2]
Thrombocytopenia [2]
Constipation [2] Toxic epidermal necrolysis [4]
Local Vasculitis [3]
Diarrhea (8%) [2] Injection-site edema (9%)
Dyspepsia (5%) Injection-site erythema (9%)
Mucosal
Nausea (21%) [3] Stomatitis [2]
Injection-site pain (9%)
Vomiting (4%) [2] Injection-site phlebitis (2%) Cardiovascular
Respiratory Injection-site thrombosis (2%) QT prolongation [7]
Rhinitis (5%) Other Torsades de pointes [9]
Sinusitis (3%) Adverse effects [2] Central Nervous System
Upper respiratory tract infection (5%) Death [3] Anorexia [2]
Endocrine/Metabolic Infection [7] Dysgeusia (taste perversion) (3%) [9]
Galactorrhea [4] Mania [4]
Hyponatremia [2] Neurotoxicity [4]
Libido decreased (2%) Psychosis [3]
SIADH [18]
CLARITHROMYCIN
Weight gain [2] Trade name: Biaxin (AbbVie) Arthralgia [2]
Genitourinary Indications: Various infections caused by Rhabdomyolysis [14]
Dysmenorrhea (3%) susceptible organisms Gastrointestinal/Hepatic
Ejaculatory dysfunction (6%) [2] Class: Antibiotic, macrolide, CYP3A4 inhibitor Abdominal distension [2]
Impotence (3%) Half-life: 57 hours Abdominal pain [5]
Priapism [4] Clinically important, potentially hazardous Diarrhea [10]
Sexual dysfunction [4] interactions with: abiraterone, alprazolam, Dyspepsia [2]
Urinary frequency [2] aprepitant, astemizole, atazanavir, atorvastatin, Hepatotoxicity [4]
Otic avanafil, benzodiazepines, betrixaban, boceprevir, Nausea [5]
Hallucinations, auditory [2] brigatinib, cabazitaxel, cabozantinib, calcifediol, Vomiting [3]
carbamazepine, chlordiazepoxide, cilostazol,
Ocular clonazepam, clorazepate, cobicistat/elvitegravir/ Endocrine/Metabolic
Diplopia [2] emtricitabine/tenofovir alafenamide, cobicistat/ Hypoglycemia [3]
Glaucoma [2] elvitegravir/emtricitabine/tenofovir disoproxil, Renal
Hallucinations, visual [3] colchicine, conivaptan, copanlisib, crizotinib, Nephrotoxicity [2]
cyclosporine, dabigatran, darunavir, dasatinib,
Litt’s Drug Eruption & Reaction Manual CLONAZEPAM
Ocular Hematologic Pregnancy category: C

Hallucinations, visual [4] Neutropenia [2] Important contra-indications noted in the
Local Otic prescribing guidelines for: the elderly; nursing
Injection-site pain [2] Tinnitus [2] mothers; pediatric patients
Warning: SUICIDALITY AND
Other Local ANTIDEPRESSANT DRUGS
Adverse effects [11] Application-site erythema [3]
Other Skin
Adverse effects [6] Acneform eruption (2%)
CLEMASTINE Death [3] Cellulitis (2%)
Dermatitis (2%)
See: www.drugeruptiondata.com/drug/id/161 Diaphoresis (29%) [2]
CLINDAMYCIN/ Edema (2%)
CLEVIDIPINE TRETINOIN Photosensitivity [3]
Pruritus (6%)
See: www.drugeruptiondata.com/drug/id/1295 See: www.drugeruptiondata.com/drug/id/1841 Purpura (3%)
Rash (8%)
Xerosis (2%)
CLIDINIUM CLIOQUINOL Mucosal
Xerostomia (84%) [6]
See: www.drugeruptiondata.com/drug/id/162 See: www.drugeruptiondata.com/drug/id/1250
Cardiovascular
Flushing (8%)
QT prolongation [4]
CLINDAMYCIN CLOBAZAM Torsades de pointes [2]
Trade names: Benzaclin (Dermik), Cleocin See: www.drugeruptiondata.com/drug/id/1128
(Pfizer), Cleocin-T (Pfizer), Clindagel (Galderma), Seizures [4]
Clindets (Stiefel) Serotonin syndrome [3]
Indications: Various serious infections caused by CLOBETASOL Neuromuscular/Skeletal
Class: Antibiotic, lincosamide Myalgia/Myopathy (13%)
Half-life: 23 hours Endocrine/Metabolic
Clinically important, potentially hazardous Gynecomastia (2%)
interactions with: cisatracurium, erythromycin, SIADH [3]
kaolin, mivacurium, neostigmine, pyridostigmine,
CLOFARABINE
Genitourinary
rocuronium, saquinavir Vaginitis (2%)
Note: See also separate entry for the Other
combination product clindamycin/tretinoin. Adverse effects [3]
CLOFAZIMINE Allergic reactions (<3%)
Skin See: www.drugeruptiondata.com/drug/id/164
AGEP [8]
Anaphylactoid reactions/Anaphylaxis [5] CLONAZEPAM
Dermatitis (from topical preparations) [7]
DRESS syndrome [2] CLOFIBRATE Trade name: Klonopin (Roche)
Erythema multiforme [2] Indications: Petit mal and myoclonic seizures
Erythroderma [2] See: www.drugeruptiondata.com/drug/id/165 Class: Benzodiazepine
Exanthems [5] Half-life: 1850 hours
Hypersensitivity [4] Clinically important, potentially hazardous
interactions with: amprenavir,
Rash (<10%) [3] CLOMIPHENE chlorpheniramine, clarithromycin, cobicistat/
Sweet’s syndrome [2] elvitegravir/emtricitabine/tenofovir disoproxil,
Toxic epidermal necrolysis [3] efavirenz, esomeprazole, imatinib, indinavir,
Urticaria [3] nelfinavir, nevirapine, oxycodone, piracetam
Vasculitis [2] Pregnancy category: D
CLOMIPRAMINE Important contra-indications noted in the
Mucosal prescribing guidelines for: the elderly; nursing
Burning mouth syndrome [2] Trade name: Anafranil (Mallinckrodt) mothers; pediatric patients
Xerostomia [2] Indications: Obsessive-compulsive disorder
Central Nervous System Class: Antidepressant, tricyclic, Muscarinic
antagonist
Skin
Ageusia (taste loss) [2] Bullous dermatitis [2]
Gastrointestinal/Hepatic Clinically important, potentially hazardous Dermatitis (<10%)
Colitis [2] interactions with: amprenavir, arbutamine, Diaphoresis (>10%)
Diarrhea [4] arsenic, artemether/lumefantrine, clonidine,
Pseudolymphoma [2]
Esophagitis [2] duloxetine, epinephrine, formoterol,
Rash (>10%)
Hepatotoxicity [3] guanethidine, isocarboxazid, linezolid, MAO Hair
Pseudomembranous colitis [5] inhibitors, milnacipran, moclobemide, phenelzine, Alopecia [2]
quinolones, sparfloxacin, tranylcypromine
CLONAZEPAM Over 100 updates per week on www.drugeruptiondata.com
Mucosal Other Neuromuscular/Skeletal

Sialopenia (>10%) Adverse effects [3] Arthralgia [5]
Sialorrhea (<10%) Rhabdomyolysis [3]
Xerostomia (>10%) Gastrointestinal/Hepatic
Central Nervous System CLOPIDOGREL Gastrointestinal bleeding [3]
Psychosis [2] Hepatotoxicity [6]
Seizures [2] Trade name: Plavix (Bristol-Myers Squibb) Respiratory
Other (Sanofi-Aventis) Dyspnea [3]
Adverse effects [2] Indications: Acute coronary syndrome, recent Flu-like syndrome (8%)
Allergic reactions (<10%) myocardial infarction, recent stroke, or
established peripheral arterial disease Hematologic
Class: Antiplatelet, Antiplatelet, thienopyridine Bleeding [16]
Half-life: 6 hours Hemolytic uremic syndrome [2]
CLONIDINE Clinically important, potentially hazardous Neutropenia [4]
interactions with: amiodarone, anisindione, Thrombocytopenia [3]
Trade name: Catapres (Boehringer Ingelheim) anticoagulants, atorvastatin, calcium channel Thrombosis [2]
Indications: Hypertension blockers, cangrelor, carbamazepine, Other
Class: Adrenergic alpha-receptor agonist chloramphenicol, cimetidine, ciprofloxacin, Adverse effects [2]
Half-life: 624 hours collagenase, dabigatran, dasatinib, delavirdine, Allergic reactions (<3%) [2]
Clinically important, potentially hazardous dexlansoprazole, diclofenac, dicumarol,
interactions with: acebutolol, alfuzosin, dipyridamole, drotrecogin alfa, efavirenz,
amitriptyline, amoxapine, atenolol, betaxolol, enoxaparin, erythromycin, esomeprazole,
captopril, carteolol, cilazapril, clomipramine, etravirine, fluconazole, fluoxetine, fluvoxamine,
CLORAZEPATE
desipramine, dexmethylphenidate, diclofenac, fondaparinux, glucosamine, herbals with
doxepin, enalapril, esmolol, fosinopril, Trade name: Tranxene (Recordati)
anticoagulant properties, ibritumomab, iloprost, Indications: Anxiety and panic disorders
imipramine, insulin aspart, insulin degludec, insulin itraconazole, ketoconazole, lansoprazole,
detemir, insulin glargine, insulin glulisine, Class: Benzodiazepine
lepirudin, macrolide antibiotics, meloxicam, Half-life: 4896 hours
irbesartan, levodopa, levomepromazine, lisinopril, miconazole, moclobemide, NSAIDs, omega-3
meloxicam, metoprolol, milnacipran, nadolol, Clinically important, potentially hazardous
fatty acids, omeprazole, oxcarbazepine, interactions with: aminophylline, amprenavir,
nebivolol, nortriptyline, olmesartan, oxprenolol, pantoprazole, pentosan, pentoxifylline, polysulfate
penbutolol, pericyazine, pindolol, propranolol, antacids, carbamazepine, carmustine,
sodium, prasugrel, rabeprazole, rifapentine, chlorpheniramine, clarithromycin, cobicistat/
protriptyline, quinapril, ramipril, sotalol, sulpiride, rivaroxaban, salicylates, simvastatin,
timolol, trandolapril, triamcinolone, tricyclic elvitegravir/emtricitabine/tenofovir alafenamide,
telithromycin, thrombolytic agents, tinzaparin, cobicistat/elvitegravir/emtricitabine/tenofovir
antidepressants, trimipramine, verapamil tositumomab & iodine131, voriconazole, warfarin
Pregnancy category: C disoproxil, efavirenz, esomeprazole, imatinib,
Pregnancy category: B indinavir, itraconazole, ketoconazole, MAO
Important contra-indications noted in the Important contra-indications noted in the
prescribing guidelines for: nursing mothers; inhibitors, midazolam, moclobemide, nelfinavir,
prescribing guidelines for: nursing mothers; phenytoin, sucralfate, warfarin
pediatric patients pediatric patients Pregnancy category: D
Note: Contra-indicated in patients with active Important contra-indications noted in the
Skin pathological bleeding. prescribing guidelines for: nursing mothers;
Depigmentation [2] Warning: DIMINISHED EFFECTIVENESS IN pediatric patients
Dermatitis (from patch) (20%) [23] POOR METABOLIZERS
Eczema [2]
Erythema [2] Skin
Skin Dermatitis (<10%)
Lupus erythematosus [5] AGEP [2]
Pigmentation [2] Diaphoresis (>10%)
Angioedema [4] Rash (>10%)
Pityriasis rosea [2] Bullous dermatitis (<3%)
Pruritus (>5%) [6] Eczema (<3%) Mucosal
Psoriasis [2] Edema (35%) Sialopenia (>10%)
Rash (<10%) [4] Exanthems (<3%) [2] Sialorrhea (<10%)
Ulcerations (<10%) Hypersensitivity [9] Xerostomia (>10%)
Mucosal Pruritus (3%) [2]
Xerostomia (40%) [13] Psoriasis [2]
Cardiovascular Purpura [18] CLOTRIMAZOLE
Bradycardia [8] Rash (4%) [5]
Hypotension [18] Stevens-Johnson syndrome [2] See: www.drugeruptiondata.com/drug/id/827
Thrombocytopenic purpura [9]
Central Nervous System Ulcerations (<3%)
Fever [2] Urticaria (<3%) [3]
Hallucinations [3] CLOXACILLIN
Headache [4] Cardiovascular
Hyperesthesia (<10%) Acute coronary syndrome [2] See: www.drugeruptiondata.com/drug/id/172
Sedation [2] Myocardial infarction [2]
Seizures [2] Central Nervous System
Somnolence (drowsiness) [4] Ageusia (taste loss) [3]
Vertigo (dizziness) [4] Fever [3]
Neuromuscular/Skeletal Hyperesthesia (<3%)
Asthenia (fatigue) [2] Intracranial hemorrhage [2]
Paresthesias (<3%)
Nausea [2]
Litt’s Drug Eruption & Reaction Manual CO-TRIMOXAZOLE
Tachycardia (25%) [11]

CLOZAPINE Venous thromboembolism [5] CO-TRIMOXAZOLE
Trade names: Clozaril (Novartis), Denzapine Central Nervous System Synonyms: sulfamethoxazole-trimethoprim;
(Merz), Leponex (Novartis), Zaponex (Teva) Akathisia [3] SMX-TMP; SMZ-TMP; TMP-SMX; TMP-SMZ
Indications: Treatment-resistant schizophrenia Anxiety [2] Trade names: Bactrim (GSK), Septra (Monarch)
Class: Antipsychotic Compulsions [9] Indications: Various infections caused by
Half-life: 4–12 hours Fever [8] susceptible organisms
Clinically important, potentially hazardous Headache (7%) Class: Antibiotic, sulfonamide
interactions with: alcohol, amitriptyline, Neuroleptic malignant syndrome [30] Half-life: 610 hours
antimuscarinics, arsenic, benzodiazepines, Neurotoxicity [2] Clinically important, potentially hazardous
cabazitaxel, caffeine, carbamazepine, Pain [2] interactions with: anticoagulants, azathioprine,
chloramphenicol, cimetidine, ciprofloxacin, Restless legs syndrome [2] cyclosporine, dofetilide, isotretinoin,
citalopram, cocoa, cyclophosphamide, cytotoxics, Sedation (39%) [11] methotrexate, prilocaine, repaglinide, warfarin
darifenacin, dasatinib, encainide, epinephrine, Seizures [25] Pregnancy category: C
erythromycin, everolimus, flecainide, fluoxetine, Somnolence (drowsiness) [10] Important contra-indications noted in the
flupentixol, fluphenazine, fluvoxamine, gefitinib, Syncope [2] prescribing guidelines for: the elderly; nursing
guarana, haloperidol, insulin degludec, insulin Tardive dyskinesia [6] mothers; pediatric patients
detemir, insulin glargine, insulin glulisine, lapatinib, Tic disorder [2] Note: Co-trimoxazole is a sulfonamide and can
lithium, lomustine, lorazepam, MAO inhibitors, Tremor (<10%) [2] be absorbed systemically. Sulfonamides can
nilotinib, norfloxacin, ofloxacin, omeprazole, Vertigo (dizziness) (19%) [2] produce severe, possibly fatal, reactions such as
oxaliplatin, oxybutynin, paroxetine hydrochloride, Neuromuscular/Skeletal toxic epidermal necrolysis and Stevens-Johnson
pazopanib, pemetrexed, penicillamine, Myoclonus [2] syndrome.
pipotiazine, propafenone, quinidine, rifampin, Rhabdomyolysis [8] Co-trimoxazole is sulfamethoxazole and
risperidone, ritonavir, saquinavir, selenium, Gastrointestinal/Hepatic trimethoprim.
sertraline, sorafenib, sulfonamides, sunitinib, Colitis [2]
telithromycin, temozolomide, temsirolimus, Constipation (14%) [6] Skin
tetrazepam, tricyclic antidepressants, trospium, Gastric obstruction [3] AGEP [4]
uracil/tegafur, valproic acid, venlafaxine, Gastrointestinal hypomotility [4] Anaphylactoid reactions/Anaphylaxis [6]
zuclopenthixol Hepatotoxicity [6] Angioedema [3]
Pregnancy category: B Ileus [6] Bullous dermatitis [2]
Important contra-indications noted in the Pancreatitis [6] Dermatitis [4]
prescribing guidelines for: the elderly; nursing DRESS syndrome [9]
mothers; pediatric patients Respiratory
Pleural effusion [4] Erythema multiforme [19]
Note: Contra-indicated in patients with Erythema nodosum [2]
myeloproliferative disorders, uncontrolled Pneumonia [3]
Pulmonary embolism [2] Exanthems [35]
epilepsy, paralytic ileus, or a history of clozapine- Exfoliative dermatitis [5]
induced agranulocytosis or severe Endocrine/Metabolic Fixed eruption [50]
granulocytopenia. Diabetes mellitus [7] Hypersensitivity [18]
Warning: AGRANULOCYTOSIS / SEIZURES / Diabetic ketoacidosis [2] Jarisch–Herxheimer reaction [2]
MYOCARDITIS / OTHER ADVERSE Galactorrhea [2] Linear IgA bullous dermatosis [4]
CARDIOVASCULAR AND RESPIRATORY Hyperglycemia [6] Lupus erythematosus [4]
EFFECTS Hyperlipidemia [3] Photosensitivity [4]
INCREASED MORTALITY IN ELDERLY Metabolic syndrome [13] Pruritus [10]
PATIENTS WITH DEMENTIA-RELATED Weight gain [28] Purpura [3]
PSYCHOSIS Genitourinary Pustules [6]
Priapism [14] Radiation recall dermatitis [3]
Renal Rash (>10%) [14]
Skin
Enuresis [4] Stevens-Johnson syndrome (<10%) [40]
Angioedema [2]
Diaphoresis (6%) [4] Hematologic Toxic epidermal necrolysis (<10%) [51]
Exanthems [2] Agranulocytosis [31] Toxicity [2]
Lupus erythematosus [4] Dyslipidemia [3] Urticaria [12]
Pityriasis rosea [2] Eosinophilia [9] Vasculitis [11]
Rash (2%) [2] Granulocytopenia [2]
Toxicity [5] Hemotoxicity [2] Mucosal
Leukopenia [10] Oral mucosal eruption [2]
Mucosal
Neutropenia [16] Oral ulceration [2]
Parotitis [3]
Sialorrhea (31%) [75] Pancytopenia [2] Cardiovascular
Xerostomia [3] Thrombosis [2] QT prolongation [2]
Ocular Torsades de pointes [3]
Cardiovascular
Atrial fibrillation [2] Maculopathy [2] Central Nervous System
Cardiomyopathy [13] Other Aseptic meningitis [5]
Cardiotoxicity [2] Adverse effects [10] Fever [4]
Hypertension (4%) [4] Death [15] Psychosis [4]
Hypotension (9%) [4] Serositis [6] Tremor [4]
Myocarditis [38] Vertigo (dizziness) [2]
Orthostatic hypotension [3] Neuromuscular/Skeletal
Pericardial effusion [3] Asthenia (fatigue) [2]
Pericarditis [8] Myalgia/Myopathy [2]
QT prolongation [5]
CO-TRIMOXAZOLE See all our books at www.crcpress.com
Rhabdomyolysis [7] hormonal contraceptives, imipramine, metoprolol, mexiletine, midazolam, naloxone,

Gastrointestinal/Hepatic immunosuppressants, itraconazole, ketoconazole, neuroleptics, nicardipine, nifedipine, non-
Hepatotoxicity [7] lidocaine, lorazepam, metoprolol, mexiletine, nucleoside reverse transcriptase inhibitors,
Nausea [2] midazolam, naloxone, neuroleptics, nicardipine, nortriptyline, oxcarbazepine, paroxetine
Pancreatitis [4] nifedipine, nortriptyline, oxcarbazepine, hydrochloride, perphenazine, phenobarbital,
Vomiting [4] paroxetine hydrochloride, perphenazine, phenytoin, propafenone, protease inhibitors,
propafenone, quinidine, rifabutin, rifapentine, quinidine, rifabutin, rifapentine, risperidone,
Endocrine/Metabolic risperidone, salmeterol, sildenafil, SSRIs, tadalafil, ritonavir, salmeterol, sedatives / hypnotics,
ALT increased [2] telithromycin, thioridazine, timolol, trazodone, sildenafil, simeprevir, sirolimus, SSRIs, tacrolimus,
Hyperkalemia [4] tricyclic antidepressants, valacyclovir, tadalafil, telithromycin, tenofovir disoproxil,
Hypoglycemia [5] valganciclovir, vardenafil, verapamil, voriconazole, thioridazine, timolol, trazodone, tricyclic
Hyponatremia [2] warfarin, zolpidem antidepressants, valacyclovir, valganciclovir,
Serum creatinine increased [4] Pregnancy category: B vardenafil, verapamil, voriconazole, warfarin,
Hematologic Important contra-indications noted in the zolpidem
Agranulocytosis [2] prescribing guidelines for: nursing mothers Pregnancy category: B
Anemia [3] Note: See also separate profiles for emtricitabine Important contra-indications noted in the
Methemoglobinemia [2] and tenofovir alafenamide. prescribing guidelines for: the elderly; nursing
Neutropenia [5] Warning: LACTIC ACIDOSIS/SEVERE mothers; pediatric patients
Thrombocytopenia [9] HEPATOMEGALY WITH STEATOSIS and POST Note: See also separate profiles for emtricitabine
Ocular TREATMENT ACUTE EXACERBATION OF and tenofovir disoproxil.
Glaucoma [2] HEPATITIS B Warning: LACTIC ACIDOSIS/SEVERE
Myopia [2] HEPATOMEGALY WITH STEATOSIS and POST
Central Nervous System TREATMENT ACUTE EXACERBATION OF
Other HEPATITIS B
Adverse effects [14] Headache (6%)
Allergic reactions [2] Neuromuscular/Skeletal
Death [4] Asthenia (fatigue) (5%) Skin
Side effects [2] Rash (3%) [3]
Diarrhea (7%) Central Nervous System
Nausea (5%) [2] Abnormal dreams (9%) [3]
COAGULATION Headache (7%) [5]
Other Insomnia (3%) [2]
Adverse effects [2]
FACTOR IX Vertigo (dizziness) (3%) [3]
(RECOMBINANT) Asthenia (fatigue) (5%) [2]
COBICISTAT/ Gastrointestinal/Hepatic
ELVITEGRAVIR/ Diarrhea (12%) [6]
Flatulence (2%)
COBICISTAT/ EMTRICITABINE/ Gastrointestinal disorder [2]
Hepatotoxicity [2]
ELVITEGRAVIR/ TENOFOVIR Nausea (16%) [8]
EMTRICITABINE/ DISOPROXIL Respiratory

Upper respiratory tract infection [2]
Trade name: Stribild (Gilead)
TENOFOVIR Indications: HIV-1 infection
Endocrine/Metabolic
AST increased (2%)
ALAFENAMIDE Class: Antiretroviral, CYP3A inhibitor
(cobicistat), Integrase strand transfer inhibitor
Serum creatinine increased [2]
(elvitegravir), Nucleoside analog reverse

Genitourinary
Trade name: Genvoya (Gilead) Hematuria (3%)
Indications: HIV-1 infection transcriptase inhibitor (emtricitabine and
Class: Antiretroviral, CYP3A inhibitor tenofovir disoproxil) Renal
(cobicistat), Hepatitis B virus necleoside analog Half-life: 3.5 hours (cobicistat); 13 hours Nephrotoxicity [2]
reverse transcriptase inhibitor (tenofovir (elvitegravir); 10 hours (emtricitabine); 12–18 Proteinuria (39%)
alafenamide), Integrase strand transfer inhibitor hours (tenofovir disoproxil) Other
(elvitegravir), Nucleoside analog reverse Clinically important, potentially hazardous Adverse effects [5]
transcriptase inhibitor (emtricitabine) interactions with: acyclovir, adefovir,
Half-life: 3.5 hours (cobicistat); 13 hours amiodarone, amitriptyline, amlodipine, antacids,
antirarrhythmics, antiretrovirals, atorvastatin,
(elvitegravir); 10 hours (emtricitabine); <1 hour
(tenofovir alafenamide) benzodiazepines, bepridil, beta blockers, COBIMETINIB
Clinically important, potentially hazardous bosentan, buprenorphine, bupropion, buspirone,
calcium channel blockers, carbamazepine, Trade name: Cotellic (Genentech)
interactions with: acyclovir, aminoglycosides, Indications: Melanoma (unresectable or
amiodarone, amitriptyline, amlodipine, antacids, cidofovir, clarithromycin, clonazepam,
clorazepate, colchicine, cyclosporine, metastatic) in patients with BRAF V600E or
antiarrhythmics, atorvastatin, benzodiazepines, V600K mutations, in combination with
bepridil, beta blockers, bosentan, buprenorphine, desipramine, dexamethasone, diazepam, digoxin,
diltiazem, disopyramide, drugs affecting renal vemurafenib
bupropion, buspirone, calcium channel blockers, Class: MEK inhibitor
cidofovir, clarithromycin, clorazepate, colchicine, function, elbasvir & grazoprevir, emtricitabine,
estazolam, ethosuximide, felodipine, flecainide, Half-life: 23–70 hours
desipramine, dexamethasone, diazepam, digoxin, Clinically important, potentially hazardous
diltiazem, disopyramide, drugs affecting renal flurazepam, fluticasone propionate, ganciclovir,
hormonal contraceptives, imipramine, interactions with: carbamazepine, efavirenz,
function, estazolam, ethosuximide, felodipine, itraconazole, phenytoin, rifampin, St John’s wort,
flecainide, flurazepam, fluticasone furoate, immunosuppressants, itraconazole, ketoconazole,
lamivudine, ledipasvir & sofosbuvir, lidocaine, strong or moderate CYP3A inhibitors or inducers
fluticasone propionate, ganciclovir, gentamicin,
Litt’s Drug Eruption & Reaction Manual COLCHICINE
Pregnancy category: N/A (Can cause fetal

harm) COCAINE CODEINE
prescribing guidelines for: nursing mothers; Indications: Topical anesthesia Synonym: methylmorphine
pediatric patients Class: Anesthetic, local, CNS stimulant Trade names: Halotussin (Watson), Nucofed
Half-life: 75 minutes (Monarch), Robitussin AC (Wyeth), Tussi-
Clinically important, potentially hazardous Organidin (MedPointe)
Skin interactions with: epinephrine, iobenguane Indications: Pain, cough suppressant
Acneform eruption (16%) [3] Pregnancy category: C (the pregnancy category Class: Opiate agonist
Basal cell carcinoma (5%) is X for non-medicinal use) Half-life: 2.54 hours
Erythema (10%) [2] Clinically important, potentially hazardous
Hyperkeratosis (11%) [3] interactions with: alcohol, cinacalcet, CNS
Keratoacanthoma [3] Skin
Angioedema [3] depressants, delavirdine, MAO inhibitors,
Photosensitivity (46%) [8] mianserin, terbinafine, tipranavir
Rash [7] Diaphoresis [3]
Hyperkeratosis (fingers and palms) [2] Pregnancy category: C
Squamous cell carcinoma (6%) [6] Important contra-indications noted in the
Necrosis [6]
Hair Purpura [4] prescribing guidelines for: the elderly; nursing
Alopecia (15%) [3] Raynaud’s phenomenon [2] mothers; pediatric patients
Mucosal Scleroderma (reversible) [3] Warning: DEATH RELATED TO ULTRA-RAPID
Stomatitis (14%) Vasculitis [14] METABOLISM OF CODEINE TO MORPHINE
Cardiovascular Mucosal
Hypertension (15%) Nasal septal perforation [4] Skin
Palatal perforation [7] Angioedema [2]
Central Nervous System Dermatitis [5]
Chills (10%) Cardiovascular Erythema multiforme [4]
Fever (28%) [3] Angina [2] Exanthems [6]
Neuromuscular/Skeletal Brugada syndrome [3] Fixed eruption [6]
Arthralgia [3] Chest pain [5] Pruritus [3]
Asthenia (fatigue) [6] Myocardial infarction [6] Rash (<10%)
Myalgia/Myopathy [2] Myocardial ischemia [2] Toxic epidermal necrolysis [2]
Gastrointestinal/Hepatic Central Nervous System Urticaria (<10%) [9]
Diarrhea (60%) [7] Ageusia (taste loss) (>10%) Mucosal
Gastrointestinal bleeding (4%) Anosmia (>10%) Xerostomia (<10%)
Hepatotoxicity [5] Compulsions [2]
Hallucinations [4] Central Nervous System
Nausea (41%) [6] Somnolence (drowsiness) [2]
Vomiting (24%) [3] Leukoencephalopathy [3]
Psychosis [2] Vertigo (dizziness) [2]
Respiratory Seizures [6] Gastrointestinal/Hepatic
Pneumonitis (<10%) Suicidal ideation [2] Constipation [3]
Endocrine/Metabolic Tic disorder [2] Nausea [2]
ALP increased (71%) [3] Tremor (<10%) Pancreatitis [5]
ALT increased (68%) [3] Neuromuscular/Skeletal Vomiting [2]
AST increased (73%) [3] Arthralgia [2] Respiratory
Creatine phosphokinase increased (79%) [4] Rhabdomyolysis [19] Respiratory depression [3]
GGT increased (65%)
Hyperkalemia (26%) Genitourinary Local
Hypoalbuminemia (42%) Priapism [5] Injection-site pain (<10%)
Hypocalcemia (24%) Renal Other
Hypokalemia (25%) Glomerulonephritis [2] Death [5]
Hyponatremia (38%) Nephrotoxicity [2]
Hypophosphatemia (68%) Hematologic
Serum creatinine increased (100%) Agranulocytosis [2] COLCHICINE
Genitourinary Hemolytic uremic syndrome [2]
Hematuria (2%) Neutropenia [6] Indications: Gouty arthritis (in adults), gout,
Hematologic Otic familial Mediterranean fever
Anemia (69%) [3] Hallucinations, auditory [2] Class: Alkaloid, Anti-inflammatory
Hemorrhage (13%) Half-life: 27–31 hours (following multiple doses)
Ocular Clinically important, potentially hazardous
Lymphopenia (73%) Hallucinations, visual [3]
Thrombocytopenia (18%) interactions with: amiodarone, aprepitant,
Other atazanavir, atorvastatin, azithromycin, boceprevir,
Ocular Death [3] clarithromycin, cobicistat/elvitegravir/
Chorioretinopathy (13%) [3] emtricitabine/tenofovir alafenamide, cobicistat/
Retinal detachment (12%) [2] elvitegravir/emtricitabine/tenofovir disoproxil,
Vision impaired (15%) conivaptan, cyanocobalamin, cyclosporine,
darunavir, dasatinib, delavirdine, digoxin,
diltiazem, efavirenz, erythromycin, fenofibrate,
fibrates, fluvastatin, gemfibrozil, grapefruit juice,
HMG-CoA reductase inhibitors, indinavir,
itraconazole, ketoconazole, lapatinib, lopinavir,
ombitasvir/paritaprevir/ritonavir, P-glycoprotein
COLCHICINE Over 100 updates per week on www.drugeruptiondata.com
inhibitors or inducers, pravastatin, protease Neuromuscular/Skeletal

inhibitors, ritonavir, rosuvastatin, saxagliptin, Myalgia/Myopathy (2%) CONIVAPTAN
simvastatin, strong CYP3A4 inhibitors, Gastrointestinal/Hepatic
telithromycin, troleandomycin, verapamil, Trade name: Vaprisol (Astellas)
Abdominal pain (4%) Indications: Hyponatremia, SIADH
voriconazole Constipation (9–10%) [3]
Pregnancy category: C Class: CYP3A4 inhibitor, Vasopressin receptor
Diarrhea (3%) antagonist
Important contra-indications noted in the Dyspepsia (4–6%) [3]
prescribing guidelines for: the elderly Half-life: 5 hours
Flatulence (11%) Clinically important, potentially hazardous
Note: Contra-indicated in patients with renal or Gastrointestinal disorder [4]
hepatic impairment where P-glycoprotein or interactions with: acetaminophen, albendazole,
Nausea (3%) alfuzosin, almotriptan, alosetron, ambrisentan,
strong CYP3A4 inhibitors are also prescribed.
Respiratory amitriptyline, amlodipine, antifungals, aprepitant,
Nasopharyngitis (4%) artemether/lumefantrine, atorvastatin,
Skin bexarotene, bortezomib, brigatinib, brinzolamide,
Pruritus [2] Endocrine/Metabolic
Hypoglycemia (3%) [3] bupivacaine, cabazitaxel, cabozantinib,
Staphylococcal scalded skin syndrome [2] ciclesonide, cilostazol, cinacalcet, citalopram,
Toxic epidermal necrolysis [3] Other clarithromycin, colchicine, copanlisib,
Vasculitis [2] Adverse effects [4] cyclobenzaprine, CYP3A4 inhibitors or
Hair substrates, darunavir, dasatinib, deferasirox,
Alopecia (<10%) [6] delavirdine, dienogest, digoxin, docetaxel,
Central Nervous System COLESTIPOL dronedarone, dutasteride, efavirenz, enalapril,
Headache (2%) eplerenone, estradiol, eszopiclone, everolimus,
Neurotoxicity [3] See: www.drugeruptiondata.com/drug/id/179 fentanyl, fesoterodine, fingolimod, flibanserin,
gefitinib, guanfacine, halofantrine, indinavir,
Neuromuscular/Skeletal itraconazole, ixabepilone, ketoconazole, lapatinib,
Asthenia (fatigue) (<4%) lomitapide, maraviroc, meloxicam, metaxalone,
Gouty tophi (4%) COLISTIN methylprednisolone, micafungin, midazolam,
Myalgia/Myopathy [20] midostaurin, mifepristone, mometasone,
Rhabdomyolysis [18] See: www.drugeruptiondata.com/drug/id/1144
neratinib, nilotinib, nisoldipine, oxybutynin,
Gastrointestinal/Hepatic pantoprazole, paricalcitol, pazopanib,
Abdominal pain (<20%) [2] pimecrolimus, pioglitazone, ponatinib, prasugrel,
Diarrhea (23%) [6] COLLAGEN (BOVINE) ramelteon, ranolazine, ribociclib, ritonavir,
Gastrointestinal disorder [2] rivaroxaban, romidepsin, rosuvastatin, ruxolitinib,
Hepatotoxicity [3] Trade names: Bellafill (Suneva), Zyderm salmeterol, saxagliptin, sildenafil, silodosin,
Nausea (<20%) [3] (Inamed), Zyplast (Inamed) simvastatin, sorafenib, St John’s wort, tadalafil,
Vomiting (<20%) [4] Indications: Cataract surgery (collagen shields), tamsulosin, telithromycin, temsirolimus,
depressed cutaneous scars, facial lines, wrinkles, terbinafine, tiagabine, tiotropium, tipranavir,
Respiratory glottic insufficiency, phonosurgey, urinary
Pharyngolaryngeal pain (3%) tolvaptan, trimethoprim, ulipristal, vardenafil,
incontinence venetoclax, vorapaxar, voriconazole, ziprasidone
Other Class: Protein Pregnancy category: C
Adverse effects [6] Half-life: Several months to years Important contra-indications noted in the
Death [3] Clinically important, potentially hazardous prescribing guidelines for: nursing mothers;
Side effects (14%) interactions with: argatroban, avitene pediatric patients
Skin
COLESEVELAM prescribing guidelines for: nursing mothers
Note: A reaction to the anesthetic, lidocaine, in Erythema (3%)
liquid collagen injections may occur. Artecoll and Peripheral edema (3–8%)
Trade names: Cholestagel (Genzyme), Welchol Pruritus (<5%)
(Sankyo) Bellafill contain polymethyl-methacrylate
Indications: Hypercholesterolemia, microspheres. Mucosal
hyperlipidemia, Type II diabetes mellitus Oral candidiasis (2%)
Class: Bile acid sequestrant Skin Xerostomia (4%)
Half-life: N/A Abscess [2] Cardiovascular
Clinically important, potentially hazardous Churg-Strauss syndrome [7] Atrial fibrillation (2–5%)
interactions with: cyclosporine, deferasirox, Dermatomyositis [3] Hypertension (6–8%)
estradiol, glyburide, levothyroxine, olmesartan, Edema [2] Hypotension (5–8%) [4]
phenytoin, warfarin Erythema [3] Orthostatic hypotension (6–14%)
Pregnancy category: B Granulomatous reaction [2] Phlebitis (32–51%)
Important contra-indications noted in the Hypersensitivity [10] Central Nervous System
prescribing guidelines for: pediatric patients Induration [3] Confusion (<5%)
Note: Contra-indicated in patients with a history Panniculitis [2] Fever (5–11%) [2]
of bowel obstruction, with serum triglyceride Neuromuscular/Skeletal Headache (8–10%)
concentrations >500 mg/dL or with a history of Arthralgia [2] Insomnia (4–5%)
hypertriglyceridemia-induced pancreatitis. Polymyositis [3] Gastrointestinal/Hepatic
Other Constipation (6–8%)
Cardiovascular Adverse effects [12] Diarrhea (<7%)
Hypertension (3%) Allergic reactions [7] Nausea (3–5%)
Central Nervous System Vomiting (5–7%)
Headache [2] Respiratory
Pharyngolaryngeal pain (<5%)
Litt’s Drug Eruption & Reaction Manual CRIZOTINIB
Pneumonia (2–5%) Hematologic sirolimus, St John’s wort, tacrolimus,

Endocrine/Metabolic Hemoglobin decreased (78%) telithromycin, troleandomycin, voriconazole
Hypokalemia (10–22%) Hyperlipasemia (21%) Pregnancy category: D
Hypomagnesemia (2–5%) Leukopenia (36%) Important contra-indications noted in the
Hyponatremia (6–8%) Lymphocytopenia (78%) prescribing guidelines for: nursing mothers;
Neutropenia (32%) pediatric patients
Genitourinary Thrombocytopenia (22%)
Urinary tract infection (4–5%)
Other Skin
Hematologic Infection (21%) Edema (38%) [11]
Anemia (5–6%) Peripheral edema [6]
Local Photosensitivity [2]
Infusion-site erythema (<6%) Rash (16%) [4]
CORTISONE
Mucosal
Infusion-site reactions (63–73%) [5] Trade name: Cortone (Merck) Stomatitis (11%)
Other Indications: Arthralgia, dermatoses Cardiovascular
Dipsia (thirst) (3–6%) [2] Class: Corticosteroid Bradycardia (5%) [6]
Half-life: N/A Cardiotoxicity [2]
Clinically important, potentially hazardous Chest pain (12%)
COPANLISIB * interactions with: chlorpropamide, diuretics,
ethambutol, live vaccines, pancuronium, rifampin
QT prolongation [6]
Pregnancy category: C Central Nervous System
Trade name: Aliqopa (Bayer) Dysgeusia (taste perversion) (13%) [5]
Indications: Relapsed follicular lymphoma in Important contra-indications noted in the
prescribing guidelines for: nursing mothers Fever (12%)
adult patients who have received at least two Headache (13%)
prior systemic therapies Insomnia (12%)
Class: Kinase inhibitor Neuromuscular/Skeletal Neurotoxicity (23%)
Half-life: 39 hours Osteonecrosis [15] Vertigo (dizziness) (24%) [5]
Clinically important, potentially hazardous Osteoporosis [10]
interactions with: boceprevir, carbamazepine, Tendinopathy/Tendon rupture [2] Neuromuscular/Skeletal
clarithromycin, cobicistat, conivaptan, danoprevir, Arthralgia (11%)
Ocular Asthenia (fatigue) (31%) [8]
dasabuvir/ombitasvir/paritaprevir/ritonavir, Cataract [5]
diltiazem, elvitegravir, enzalutamide, grapefruit Back pain (11%)
Glaucoma [8] Bone or joint pain [2]
juice, idelalisib, indinavir, itraconazole,
ketoconazole, lopinavir, mitotane, nefazodone, Other Gastrointestinal/Hepatic
nelfinavir, phenytoin, posaconazole, rifampin, Adverse effects [2] Abdominal pain (16%)
ritonavir, saquinavir, St John’s wort, strong CYP3A Constipation (38%) [13]
inhibitors and inducers, tipranavir, Diarrhea (49%) [23]
troleandomycin, voriconazole CRISABOROLE * Dyspepsia [3]
Pregnancy category: N/A (Can cause fetal Dysphagia [3]
harm) Trade name: Eucrisa (Pfizer) Esophagitis [8]
Important contra-indications noted in the Indications: Atopic dermatitis Gastroesophageal reflux [2]
prescribing guidelines for: nursing mothers; Class: Phosphodiesterase type 4 (PDE4) inhibitor Hepatitis [2]
pediatric patients Half-life: N/A Hepatotoxicity [11]
Clinically important, potentially hazardous Nausea (57%) [22]
Skin interactions with: none known Vomiting (45%) [22]
Rash (15%) Pregnancy category: N/A (No available data) Respiratory
Important contra-indications noted in the Cough (21%)
Mucosal prescribing guidelines for: nursing mothers;
Mucosal inflammation (8%) Dyspnea (22%)
pediatric patients Pneumonitis [6]
Stomatitis (14%)
Cardiovascular Local Upper respiratory tract infection (20%)
Hypertension (26%) [2] Application-site pain (4%) [3] Endocrine/Metabolic
Central Nervous System ALT increased (15%) [11]
Dysesthesia (7%) Appetite decreased (27%) [4]
Paresthesias (7%) CRIZOTINIB AST increased (11%) [9]
Neuromuscular/Skeletal Dehydration [2]
Asthenia (fatigue) (36%) Trade name: Xalkori (Pfizer) Hypocalcemia [2]
Gastrointestinal/Hepatic Indications: Advanced or metastatic non-small Hypogonadism [6]
Diarrhea (36%) cell lung cancer in ALK-positive patients Hypophosphatemia [5]
Nausea (26%) Class: Tyrosine kinase inhibitor Renal
Vomiting (13%) Half-life: 42 hours Nephrotoxicity [8]
Respiratory interactions with: alfentanil, atazanavir, Hematologic
Pneumonitis (9%) carbamazepine, clarithromycin, cyclosporine, Anemia [3]
Endocrine/Metabolic CYP3A inhibitors or inducers, CYP3A substrates, Lymphopenia (11%) [5]
Hyperglycemia (54%) [3] dihydroergotamine, efavirenz, ergotamine, Neutropenia (5%) [9]
Hypertriglyceridemia (58%) fentanyl, grapefruit juice, indinavir, itraconazole, Ocular
Hyperuricemia (25%) ketoconazole, nefazodone, nelfinavir, neratinib, Diplopia [2]
Hypophosphatemia (44%) olaparib, phenobarbital, phenytoin, pimozide, Ocular adverse effects (64%) [13]
quinidine, rifabutin, rifampin, ritonavir, saquinavir, Photophobia [2]
CRIZOTINIB See all our books at www.crcpress.com
Photopsia [3] Other Neuromuscular/Skeletal

Reduced visual acuity [2] Infection (giardiasis) (2%) Asthenia (fatigue) (6%) [3]
Vision blurred [4] Gastrointestinal/Hepatic
Vision impaired [3] Abdominal pain (<3%)
Visual disturbances [15]
Vitreous floaters [2]
CROMOLYN Constipation (<3%) [3]
Diarrhea (<3%)
Other See: www.drugeruptiondata.com/drug/id/181 Nausea (<3%)
Adverse effects [5] Respiratory
Death [2] Pharyngitis (<3%)
CYANOCOBALAMIN Upper respiratory tract infection (<3%)
Ocular
CROFELEMER Synonym: Vitamin B12 Vision blurred (<3%)
Trade name: Nascobal (Nastech)
Trade name: Fulyzaq (Salix) Indications: Vitamin B12 deficiency, pernicious Other
Indications: Non-infectious diarrhea in adult anemia Adverse effects [2]
patients with HIV/AIDS on anti-retroviral therapy Class: Vitamin
Class: Proanthocyanidin oligomer Half-life: 6 days
Half-life: N/A Clinically important, potentially hazardous CYCLOPENTHIAZIDE
Clinically important, potentially hazardous interactions with: colchicine
interactions with: none known Pregnancy category: C See: www.drugeruptiondata.com/drug/id/1419
Acneform eruption [8] CYCLOPHOSPHAMIDE
Note: Derived from the red latex of Croton Dermatitis [2] Synonyms: CPM; CTX; CYT
lechleri which is also known as Sangre de Drago Exanthems [3] Trade names: Cytoxan (Mead Johnson), Neosar
or dragon’s blood. Hypersensitivity [2] (Gensia)
Nicolau syndrome [2] Indications: Lymphomas, minimal change
Skin Pruritus (<10%) nephrotic syndrome in pediatric patients
Acneform eruption (<2%) Urticaria [7] Class: Alkylating agent
Dermatitis (<2%) Other Half-life: 3–12 hours
Herpes zoster (<2%) Allergic reactions [3] Clinically important, potentially hazardous
Mucosal interactions with: aldesleukin, azathioprine,
Xerostomia (<2%) belimumab, clozapine, cyclopenthiazide,
cyclosporine, dexamethasone, etanercept,
Central Nervous System CYCLAMATE itraconazole, mycophenolate, pentostatin,
Anxiety (2%) prednisone, vaccines
Depression (<2%) See: www.drugeruptiondata.com/drug/id/183 Pregnancy category: D
Vertigo (dizziness) (<2%) Important contra-indications noted in the
Neuromuscular/Skeletal prescribing guidelines for: nursing mothers
Arthralgia (3%) CYCLOBENZAPRINE Note: Contra-indicated in patients with urinary
Back pain (3%) outflow obstruction.
Bone or joint pain (2%) Trade name: Flexeril (McNeil)
Pain in extremities (<2%) Indications: Muscle spasms Skin
Gastrointestinal/Hepatic Class: Central muscle relaxant Acral erythema [3]
Abdominal distension (2%) Half-life: 8–37 hours Anaphylactoid reactions/Anaphylaxis [3]
Abdominal pain (<2%) Clinically important, potentially hazardous Edema [5]
Constipation (<2%) interactions with: acetylcholinesterase Exanthems [4]
Dyspepsia (<2%) inhibitors, anticholinergics, barbiturates, Graft-versus-host reaction [2]
Flatulence (3%) cisapride, CNS depressants, conivaptan, CYP1A2 Hand–foot syndrome [10]
Gastroenteritis (<2%) inhibitors, droperidol, levomepromazine, Herpes zoster [4]
Nausea (3%) linezolid, MAO inhibitors, phendimetrazine, Hypersensitivity [6]
pramlintide, safinamide Kaposi’s sarcoma [2]
Respiratory Pregnancy category: B
Bronchitis (4%) Lupus erythematosus [2]
Important contra-indications noted in the Lymphoma [4]
Cough (4%) prescribing guidelines for: the elderly; nursing
Nasopharyngitis (2%) Malignancies [2]
mothers; pediatric patients Pemphigus [2]
Sinusitis (<2%)
Upper respiratory tract infection (6%) Pigmentation [16]
Mucosal Radiation recall dermatitis [6]
Endocrine/Metabolic Xerostomia (7–32%) [7] Rash (<10%) [6]
ALT increased (2%) Scleroderma [2]
AST increased (<2%) Central Nervous System
Confusion (<3%) Squamous cell carcinoma [2]
Genitourinary Dysgeusia (taste perversion) (<3%) Stevens-Johnson syndrome [2]
Pollakiuria (<2%) Headache (5%) [3] Toxicity [6]
Renal Irritability (<3%) Urticaria [8]
Nephrolithiasis (<2%) Nervousness (<3%) Vasculitis [2]
Hematologic Serotonin syndrome [3] Hair
Leukopenia (<2%) Somnolence (drowsiness) (29–39%) [8] Alopecia [28]
Litt’s Drug Eruption & Reaction Manual CYCLOSPORINE
Nails glecaprevir & pibrentasvir, grapefruit juice,

Leukonychia (Mees’ lines) (Muehrcke’s lines) CYCLOSERINE Hemophilus B vaccine, HMG-CoA reductase
[3] inhibitors, imatinib, imipenem/cilastatin, indinavir,
Melanonychia [2] Trade name: Seromycin (Lilly) influenza vaccine, irbesartan, itraconazole,
Nail pigmentation [16] Indications: Tuberculosis ketoconazole, lanreotide, levofloxacin, lisinopril,
Class: Antibiotic lopinavir, lovastatin, meloxicam, mephenytoin,
Mucosal Half-life: 10 hours
Gingival pigmentation [2] methicillin, methoxsalen, methylphenidate,
Clinically important, potentially hazardous methylprednisolone, methyltestosterone,
Mucositis [3] interactions with: none known
Oral ulceration [2] mezlocillin, micafungin, mifepristone, mizolastine,
Pregnancy category: C moxifloxacin, mycophenolate, nafcillin,
Stomatitis (10%) [6] Important contra-indications noted in the naldemedine, natalizumab, nelfinavir, neratinib,
Cardiovascular prescribing guidelines for: nursing mothers; nevirapine, nifedipine, nisoldipine, norfloxacin,
Cardiotoxicity [6] pediatric patients NSAIDs, ofloxacin, olmesartan, omeprazole,
Flushing (<10%) orlistat, osimertinib, oxacillin, oxcarbazepine,
Hypotension [2] Skin pasireotide, penicillins, phenytoin, pitavastatin,
Central Nervous System Dermatitis [2] posaconazole, pravastatin, prednisolone,
Anorexia [2] Exanthems [4] prednisone, pristinamycin, quinapril, rabeprazole,
Dysgeusia (taste perversion) [2] Lichenoid eruption [2] ramipril, ranolazine, ribociclib, rifabutin, rifampin,
Fever [3] rifapentine, ritonavir, rosuvastatin, sevelamer,
Mucosal
Headache [3] silodosin, simvastatin, sirolimus, sofosbuvir/
Gingival hyperplasia/hypertrophy [3]
Leukoencephalopathy [6] velpatasvir/voxilaprevir, spironolactone, St John’s
Neurotoxicity [7] Central Nervous System wort, sulfacetamide, sulfadiazine,
Peripheral neuropathy [6] Depression [2] sulfamethoxazole, sulfisoxazole, sulfonamides,
Neurotoxicity [2] tacrolimus, telithromycin, temsirolimus,
Neuromuscular/Skeletal Psychosis [7] tenoxicam, terbinafine, testosterone, ticarcillin,
Arthralgia [2] Seizures [4] tinidazole, tipranavir, tofacitinib, tolvaptan,
Renal trabectedin, trandolapril, triamterene,
Nephrotoxicity [2] trimethoprim, troleandomycin, ursodiol, vaccines,
Gastrointestinal/Hepatic vecuronium, venetoclax, voriconazole, warfarin,
Abdominal pain [2] Other
zofenopril
Diarrhea [8] Adverse effects [4]
Hepatotoxicity [11] Important contra-indications noted in the
Nausea [10] prescribing guidelines for: nursing mothers;
Vomiting [11] CYCLOSPORINE pediatric patients
Respiratory Note: Restasis is an ophthalmic emulsion.
Pneumonia [4] Synonyms: CsA; CyA
Trade names: Neoral (Novartis), Restasis
Endocrine/Metabolic Skin
(Allergan), Sandimmune (Novartis)
Amenorrhea [16] Acne keloid [2]
Indications: Rheumatoid arthritis, prophylaxis of
Hyperglycemia [2] Acneform eruption [7]
organ rejection in transplants, psoriasis, Restasis is
Hyponatremia [3] Anaphylactoid reactions/Anaphylaxis [8]
indicated for patients with moderate-to-severe
Menstrual irregularities [2] Basal cell carcinoma [4]
dry eye syndrome
SIADH [9] Candidiasis [2]
Class: Calcineurin inhibitor, Disease-modifying
Cyst [5]
Genitourinary antirheumatic drug (DMARD),
Edema (5–14%)
Cystitis [10] Immunosuppressant
Fibroadenoma [2]
Urinary tract infection [2] Half-life: 1027 hours (adults)
Folliculitis [8]
Hematologic Clinically important, potentially hazardous
Herpes simplex [4]
Anemia [9] interactions with: afatinib, aliskiren,
Herpes zoster [2]
Cytopenia [2] ambrisentan, amiloride, aminoglycosides,
Hot flashes [2]
Febrile neutropenia [14] amiodarone, amphotericin B, ampicillin,
Hemorrhage [2] amprenavir, anisindione, anticoagulants,
Kaposi’s sarcoma [5]
Hemotoxicity [10] armodafinil, atazanavir, atorvastatin, azathioprine,
Keratoses [3]
Leukopenia [12] azithromycin, bacampicillin, basiliximab,
Keratosis pilaris [2]
Lymphopenia [3] benazepril, bezafibrate, boceprevir, bosentan,
Linear IgA bullous dermatosis [2]
Myelosuppression [4] bupropion, captopril, carbenicillin, caspofungin,
Lymphocytic infiltration [5]
Neutropenia [33] ceritinib, cholestyramine, cholic acid, choline
Lymphoma [12]
Sepsis [2] fenofibrate, cilazapril, ciprofloxacin,
Lymphoproliferative disease [2]
Thrombocytopenia [16] clarithromycin, cloxacillin, co-trimoxazole,
Malignancies [2]
cobicistat/elvitegravir/emtricitabine/tenofovir
Local Mycosis fungoides [2]
disoproxil, colchicine, colesevelam,
Infusion-related reactions [2] Peripheral edema [3]
corticosteroids, crizotinib, cyclophosphamide,
Pruritus (<2%) [2]
Other dabigatran, daclizumab, danazol, daptomycin,
Pseudolymphoma [6]
Adverse effects [16] darifenacin, darunavir, dasatinib, delavirdine,
Psoriasis [2]
Allergic reactions [2] dichlorphenamide, diclofenac, dicloxacillin,
Purpura (3%) [4]
Death [9] dicumarol, digoxin, diltiazem, disulfiram,
Rash (7–12%)
Hiccups [4] docetaxel, doxycycline, dronedarone, echinacea,
Raynaud’s phenomenon [2]
Infection [21] efavirenz, elbasvir & grazoprevir, eluxadoline,
Sebaceous hyperplasia [9]
enalapril, enzalutamide, erythromycin, ethotoin,
Squamous cell carcinoma [12]
etoposide, etoricoxib, everolimus, ezetimibe,
flunisolide, fluoxymesterone, fluvastatin,
Toxicity [2]
foscarnet, fosinopril, fosphenytoin, gemfibrozil,
CYCLOSPORINE Over 100 updates per week on www.drugeruptiondata.com
Urticaria [2] Upper respiratory tract infection (8–15%) Respiratory

Vasculitis [3] Endocrine/Metabolic Dyspnea [4]
Hair Diabetes mellitus [2]
Alopecia (3–4%) [2] Gynecomastia (>3%) [3]
Alopecia areata [6] Hypertriglyceridemia [2] CYSTEAMINE
Hirsutism [10] Hypomagnesemia (4–6%)
Hypertrichosis (5–19%) [33] Menstrual irregularities (<3%) See: www.drugeruptiondata.com/drug/id/2637
Pseudofolliculitis barbae [2] Serum creatinine increased (16–43%) [4]
Nails Genitourinary
Brittle nails (<2%) Urinary frequency (2–4%) CYTARABINE
Leukonychia (Mees’ lines) [2] Urinary tract infection (3%)
Mucosal Renal Synonym: ara-C
Aphthous stomatitis [2] Nephrotoxicity [94] Trade names: Cytosar-U (Sicor), DepoCyt
Gingival hyperplasia/hypertrophy (2–6%) Renal function abnormal [2] (Pacira)
[157] Indications: Leukemias
Hematologic Class: Antimetabolite, Antineoplastic, Antiviral
Gingivitis (3–4%) Anemia [3]
Oral ulceration [2] Half-life: initial: 1015 minutes
Dyslipidemia [4] Clinically important, potentially hazardous
Rectal hemorrhage (<3%) Hemolytic uremic syndrome [17]
Stomatitis (5–7%) interactions with: aldesleukin
Leukopenia [2] Pregnancy category: D
Cardiovascular Neutropenia [2] Important contra-indications noted in the
Arrhythmias (2–5%) Ocular prescribing guidelines for: nursing mothers;
Capillary leak syndrome [2] Hallucinations, visual [2] pediatric patients
Chest pain (4–6%) Ocular burning (Restasis) (17%) Note: DepoCyt is a liposomal formulation.
Flushing (2–5%) [5] Papilledema [2] Vasculitis, a part of the cytarabine syndrome,
Hypertension (8–28%) [26] consists of fever, malaise, myalgia, conjunctivitis,
Other
Central Nervous System Adverse effects [19] arthralgia and a diffuse erythematous
Anorexia (3%) Infection [6] maculopapular eruption that occurs from 6–12
Depression (<6%) hours following the administration of the drug.
Dysesthesia [2] Warning: DepoCyt: CHEMICAL
Encephalopathy [4] ARACHNOIDITIS ADVERSE REACTIONS
Fever (3–6%) CYCLOTHIAZIDE
Headache (14–25%) [4] Skin
Insomnia (<4%) See: www.drugeruptiondata.com/drug/id/188
Acral erythema [16]
Leukoencephalopathy [17] Anaphylactoid reactions/Anaphylaxis [3]
Migraine (2–3%) Ephelides (<10%)
Neurotoxicity [10] CYPROHEPTADINE Erythema [5]
Pain (3–13%) Exanthems [7]
Paresthesias (5–11%) [8] See: www.drugeruptiondata.com/drug/id/189 Hand–foot syndrome [21]
Parkinsonism [6] Herpes zoster [2]
Pseudotumor cerebri [3] Hypersensitivity [2]
Rigors (<3%) CYPROTERONE Neutrophilic eccrine hidradenitis [11]
Seizures [4] Pruritus (<10%)
Tremor (7–13%) [4] Trade name: Androcur (Bayer) Rash (>10%) [4]
Vertigo (dizziness) (6–8%) Indications: Control of libido in severe Seborrheic keratoses (inflammation of)
Neuromuscular/Skeletal hypersexuality and/or sexual deviation in the adult (Leser–Trélat syndrome) [2]
Arthralgia (<6%) male Toxic epidermal necrolysis [2]
Asthenia (fatigue) (3–6%) [4] Class: Androgen antagonist, Progesterone agonist Toxicity [5]
Myalgia/Myopathy [10] Half-life: 1.7 days Vasculitis [3]
Rhabdomyolysis [13] Clinically important, potentially hazardous Hair
Gastrointestinal/Hepatic interactions with: alcohol, clotrimazole, Alopecia (<10%) [5]
Abdominal pain (15%) [3] fingolimod, itraconazole, ketoconazole,
pazopanib, phenytoin, rifampin, ritonavir, St John’s Nails
Diarrhea (5–13%) [3] Leukonychia (Mees’ lines) [2]
Dyspepsia (2–12%) wort
Flatulence (4–5%) Pregnancy category: X (not indicated for use in Mucosal
Gastrointestinal disorder (2–4%) [2] women) Mucositis [3]
Hepatotoxicity [9] Important contra-indications noted in the Oral lesions [5]
Nausea (6–23%) prescribing guidelines for: pediatric patients Oral ulceration (>10%)
Vomiting (6–9%) Perianal ulcerations (>10%)
Skin Stomatitis [2]
Respiratory
Bronchitis (<3%) Tumors [3] Cardiovascular
Bronchospasm (5%) Cardiovascular Thrombophlebitis (>10%)
Cough (3–5%) Venous thromboembolism [2] Central Nervous System
Dyspnea (<5%) Neuromuscular/Skeletal Fever [3]
Influenza (<10%) Osteoporosis [2] Headache [4]
Pharyngitis (3–4%) Leukoencephalopathy [8]
Pneumonia (<4%) Gastrointestinal/Hepatic Neurotoxicity [10]
Rhinitis (<5%) Hepatotoxicity [24] Peripheral neuropathy [2]
Sinusitis (3–4%)
Litt’s Drug Eruption & Reaction Manual CYTARABINE
Neuromuscular/Skeletal Endocrine/Metabolic Thrombocytopenia [5]

Myalgia/Myopathy (<10%) Hypokalemia [2] Ocular
Rhabdomyolysis [3] Hematologic Ocular adverse effects [2]
Gastrointestinal/Hepatic Anemia [2] Local
Diarrhea [5] Bleeding [2] Injection-site cellulitis (<10%)
Hepatotoxicity [5] Febrile neutropenia [8]
Nausea [4] Hemotoxicity [3] Other
Pancreatitis [5] Leukopenia [2] Adverse effects [5]
Vomiting [4] Myelosuppression [3] Death [4]
Neutropenia [7] Infection [6]
Respiratory
Pneumonia [3] Sepsis [2]
DABIGATRAN See all our books at www.crcpress.com
Endocrine/Metabolic
DABIGATRAN DABRAFENIB ALP increased (19%) [2]
ALT increased [3]
Trade name: Pradaxa (Boehringer Ingelheim) Trade name: Tafinlar (Novartis) Appetite decreased [3]
Indications: Prevention of venous Indications: Melanoma (unresectable or AST increased [3]
thromboembolic events, reduce stroke risk metastatic) in patients with BRAF V600E mutation Hyperglycemia (50%)
Class: Anticoagulant, Thrombin inhibitor Class: BRAF inhibitor, Kinase inhibitor Hyponatremia (8%) [2]
Half-life: 2.5 days Half-life: 8 hours Hypophosphatemia (37%)
interactions with: amiodarone, antacids, interactions with: strong CYP3A4 or CYP2C8 Renal
anticoagulants, atorvastatin, carbamazepine, inducers or inhibitors Nephrotoxicity (<10%) [2]
clarithromycin, clopidogrel, collagenase, Pregnancy category: D Hematologic
cyclosporine, darunavir, dasatinib, deferasirox, Important contra-indications noted in the Anemia [5]
desirudin, dextran, diclofenac, dronedarone, prescribing guidelines for: nursing mothers; Leukopenia [2]
fondaparinux, heparin, ibritumomab, pediatric patients Neutropenia [4]
itraconazole, ketoconazole, ketorolac, lapatinib, Other
meloxicam, nandrolone, neratinib, NSAIDs, P- Skin Adverse effects [7]
glycoprotein inducers and inhibitors, Acneform eruption [4]
pantoprazole, pentosan, phenytoin, polysulfate Actinic keratoses [3]
sodium, prostacyclin analogues, proton pump Basal cell carcinoma [4]
inhibitors, quinidine, rifampin, rivaroxaban, Bullae (<10%)
DACARBAZINE
salicylates, St John’s wort, sulfinpyrazone, Erythema [2]
tacrolimus, telaprevir, thrombolytic agents, Synonym: DIC
Exanthems [2] Trade name: DTIC-Dome (Bayer)
ticlopidine, tipranavir, tositumomab & iodine131, Grover’s disease [4]
ulipristal, verapamil, vitamin K antagonists Indications: Malignant melanoma, carcinomas
Hand–foot syndrome (20%) [6] Class: Alkylating agent, Antineoplastic
Pregnancy category: C Hyperkeratosis (37%) [12]
Hypersensitivity (<10%) Clinically important, potentially hazardous
prescribing guidelines for: the elderly; nursing Keratoacanthoma (7%) [7]
mothers; pediatric patients interactions with: aldesleukin
Keratosis pilaris [4] Pregnancy category: C
Note: Contra-indicated in patients with active Lesions [2]
pathological bleeding or with a mechanical Important contra-indications noted in the
Malignant melanoma (2%) prescribing guidelines for: nursing mothers
prosthetic heart valve. Panniculitis [6]
Warning: DISCONTINUING PRADAXA IN Papillomas (27%) [4]
PATIENTS WITHOUT ADEQUATE Peripheral edema [2] Skin
CONTINUOUS ANTICOAGULATION Photosensitivity [7] Anaphylactoid reactions/Anaphylaxis
INCREASES RISK OF STROKE Pruritus [3] (<10%)
Rash (17%) [5] Hypersensitivity [2]
Skin Seborrheic keratoses [2] Photosensitivity [10]
Bruising (<10%) Squamous cell carcinoma (7%) [17] Rash (<10%) [2]
Exanthems [2] Toxicity [4] Urticaria [2]
Rash [2] Xerosis [4] Hair
Mucosal Hair Alopecia (<10%) [3]
Epistaxis (nosebleed) [2] Alopecia (22%) [7] Mucosal
Cardiovascular Hair changes [2] Stomatitis (48%)
Myocardial infarction [5] Cardiovascular Cardiovascular
Central Nervous System Chest pain [2] Flushing (<10%) [2]
Headache [2] Hypertension [3] Central Nervous System
Intracranial hemorrhage [4] Central Nervous System Dysgeusia (taste perversion) (<10%)
Subarachnoid hemorrhage [2] Chills [4] Neuromuscular/Skeletal
Gastrointestinal/Hepatic Fever (28%) [20] Asthenia (fatigue) (75%) [4]
Abdominal pain [2] Headache (32%) [7] Myalgia/Myopathy (<10%)
Dyspepsia (11%) [7] Intracranial hemorrhage [3]
Esophagitis [3] Neuromuscular/Skeletal Hepatotoxicity [3]
Gastritis [2] Arthralgia (27%) [9] Nausea [3]
Gastrointestinal bleeding (6%) [10] Asthenia (fatigue) [12] Vomiting [2]
Renal Back pain (12%)
Myalgia/Myopathy (11%) [2] Respiratory
Renal failure [4] Flu-like syndrome [2]
Hematologic Gastrointestinal/Hepatic
Abdominal pain [2] Endocrine/Metabolic
Anemia (<4%) ALT increased [2]
Anticoagulation [2] Constipation (11%) [2]
Diarrhea [3] AST increased [2]
Hemorrhage [9]
Thrombosis [3] Nausea [8] Hematologic
Pancreatitis (<10%) Neutropenia [4]
Other Vomiting [6] Thrombocytopenia [2]
Adverse effects [6]
Death [6] Respiratory Local
Cough (12%) [2] Injection-site burning (>10%)
Nasopharyngitis (10%) Injection-site necrosis (>10%)
Injection-site pain (>10%)
Litt’s Drug Eruption & Reaction Manual DALBAVANCIN
Other Pregnancy category: C Endocrine/Metabolic

Adverse effects [7] Important contra-indications noted in the ALT increased [2]
prescribing guidelines for: the elderly; nursing AST increased [2]
mothers; pediatric patients Dehydration (2–5%)
Warning: Zinbryta: HEPATIC INJURY
DACLATASVIR INCLUDING AUTOIMMUNE HEPATITIS and
Diabetes mellitus (2–5%)
Genitourinary
Trade name: Daklinza (Bristol-Myers Squibb) OTHER IMMUNE-MEDIATED DISORDERS Urinary retention (2–5%)
Indications: Hepatitis C (in combination with Urinary tract infection [2]
sofosbuvir) Skin Renal
Class: Direct-acting antiviral, Hepatitis C virus Acneform eruption (>5%) Nephrotoxicity (2–5%)
NS5A inhibitor Dermatitis [2]
Half-life: 12–15 hours Eczema [6] Hematologic
Clinically important, potentially hazardous Edema (>5%) Hemorrhage (>5%)
interactions with: amiodarone, carbamazepine, Hypersensitivity [2] Thrombosis (>5%)
dabigatran, phenytoin, rifampin, St John’s wort Hypohidrosis (2–5%) Ocular
Pregnancy category: N/A (No data available) Lymphadenopathy [4] Vision blurred (2–5%)
Important contra-indications noted in the Peripheral edema (>5%)
Local
prescribing guidelines for: nursing mothers; Pruritus (2–5%)
Application-site reactions (2–5%)
pediatric patients Psoriasis [2]
Note: See also separate entry for sofosbuvir. Rash (2–5%) [8] Other
Toxicity [2] Adverse effects [4]
Wound complications (>5%) Infection [7]
Skin
Pruritus [3] Hair
Rash [2] Hirsutism (2–5%)
Central Nervous System Cardiovascular
DACTINOMYCIN
Fever [4] Chest pain (>5%)
Synonyms: ACT; actinomycin-D
Headache (14%) [17] Hypertension (>5%)
Trade name: Cosmegen (Merck)
Insomnia [4] Hypotension (>5%)
Indications: Melanomas, sarcomas
Neuromuscular/Skeletal Pulmonary edema (>5%)
Class: Antibiotic, anthracycline
Asthenia (fatigue) (14%) [14] Tachycardia (>5%)
Half-life: 36 hours
Gastrointestinal/Hepatic Central Nervous System Clinically important, potentially hazardous
Abdominal pain [2] Anxiety (2–5%) interactions with: aldesleukin
Diarrhea (5%) [10] Depression (2–5%) Pregnancy category: D
Nausea (8%) [12] Fever (>5%) Important contra-indications noted in the
Headache (>5%) [3] prescribing guidelines for: the elderly; nursing
Respiratory Insomnia (>5%) mothers; pediatric patients
Nasopharyngitis [2] Pain (>5%) Note: Contra-indicated in patients with
Endocrine/Metabolic Tremor (>5%) chickenpox or herpes zoster infection.
ALT increased [10] Vertigo (dizziness) (>5%)
AST increased [4] Neuromuscular/Skeletal Skin
Hematologic Arthralgia (2–5%) Acneform eruption (>10%) [6]
Anemia [6] Asthenia (fatigue) (>5%) Erythema [2]
Lymphopenia [2] Back pain (>5%) Folliculitis [2]
Neutropenia [3] Bone or joint pain (>5%) Pigmentation [4]
Thrombocytopenia [2] Myalgia/Myopathy (2–5%) Pruritus [2]
Other Gastrointestinal/Hepatic Pustules [2]
Adverse effects [8] Abdominal distension (>5%) Radiation recall dermatitis (>10%) [4]
Abdominal pain (>5%) Hair
Colitis [2] Alopecia (>10%)
Constipation (>5%)
DACLIZUMAB Diarrhea (>5%)
Mucosal
Oral lesions [3]
Flatulence (2–5%)
Trade names: Zenapax (Roche), Zinbryta Stomatitis (ulcerative) (>5%)
(Biogen)
Gastritis (2–5%)
Hemorrhoids (2–5%) Hematologic
Indications: Transplant rejection (Zenapax), Febrile neutropenia [2]
relapsing forms of multiple sclerosis (Zinbryta)
Hepatotoxicity [5]
Nausea (>5%) Neutropenia [2]
Class: Immunosuppressant, Monoclonal antibody Thrombocytopenia [2]
Half-life: 11–38 days
Vomiting (>5%)
Clinically important, potentially hazardous Respiratory Local
interactions with: corticosteroids, cyclosporine, Cough (>5%) Injection-site extravasation (>10%)
Hemophilus B vaccine, methylprednisolone, Dyspnea (>5%) Injection-site necrosis (>10%)
mycophenolate, prednisolone Hypoxia (2–5%) Injection-site phlebitis (>10%)
Nasopharyngitis [2]
Pharyngitis (2–5%)
Pleural effusion (2–5%) DALBAVANCIN
Pneumonia [2]
Rhinitis (2–5%) See: www.drugeruptiondata.com/drug/id/1323
DALFAMPRIDINE Over 100 updates per week on www.drugeruptiondata.com
Injection-site pain (<10%) Skin

DALFAMPRIDINE Other Acneform eruption [3]
Allergic reactions (<10%) [3] Rash (>10%)
Synonym: 4-aminopyridine
Trade name: Ampyra (Acorda) Cardiovascular
Indications: Multiple sclerosis (to improve Pericarditis [3]
walking) DANAPAROID Central Nervous System
Class: Potassium channel blocker Chills (<10%)
Half-life: 5–6.5 hours See: www.drugeruptiondata.com/drug/id/835 Vertigo (dizziness) [2]
Clinically important, potentially hazardous Neuromuscular/Skeletal
interactions with: none known Asthenia (fatigue) [2]
DANAZOL Myalgia/Myopathy [2]
prescribing guidelines for: nursing mothers; Gastrointestinal/Hepatic
Indications: Endometriosis, fibrocystic breast
pediatric patients Hepatotoxicity [2]
disease
Note: Contra-indicated in patients with a history Class: Pituitary hormone inhibitor Respiratory
of seizure, or with moderate or severe renal Half-life: ~4.5 hours Eosinophillic pleural effusion [3]
impairment. Clinically important, potentially hazardous Pleural effusion [5]
interactions with: acenocoumarol, acitretin, Other
Central Nervous System atorvastatin, cyclosporine, insulin aspart, insulin Adverse effects [2]
Balance disorder (5%) degludec, insulin detemir, insulin glargine, insulin Death [4]
Gait instability [2] glulisine, oral contraceptives, paricalcitol,
Headache (7%) [5] simvastatin, tacrolimus, warfarin
Insomnia (9%) [5] Pregnancy category: X
Multiple sclerosis (relapse) (4%) Important contra-indications noted in the
DAPAGLIFLOZIN
Paresthesias (4%) [2] prescribing guidelines for: nursing mothers;
Trade names: Farxiga (AstraZeneca), Qtern
Seizures [5] pediatric patients
(AstraZeneca), Xigduo XR (AstraZeneca)
Vertigo (dizziness) (7%) [9] Indications: Type II diabetes mellitus
Neuromuscular/Skeletal Skin Class: Sodium-glucose co-transporter 2 (SGLT2)
Asthenia (fatigue) (7%) [3] Acneform eruption (>10%) [6] inhibitor
Back pain (5%) Diaphoresis (3%) Half-life: 13 hours
Gastrointestinal/Hepatic Edema (>10%) Clinically important, potentially hazardous
Constipation (3%) Erythema multiforme [2] interactions with: pioglitazone
Dyspepsia (2%) Exanthems [2] Pregnancy category: C
Nausea (7%) [4] Lupus erythematosus [4] Important contra-indications noted in the
Rash (3%) prescribing guidelines for: the elderly; nursing
Respiratory Seborrhea [4] mothers; pediatric patients
Nasopharyngitis (4%) Note: Contra-indicated in patients with severe
Pharyngolaryngeal pain (2%) Hair
Alopecia [3] renal impairment, end-stage renal disease, or
Genitourinary Hirsutism (<10%) [5] undergoing dialysis. Qtern is dapagliflozin and
Urinary tract infection (12%) [2] saxagliptin; Xigduo XR is dapagliflozin and
Cardiovascular metformin.
Other Flushing [3]
Adverse effects [4]
Neuromuscular/Skeletal Skin
Rhabdomyolysis [5] Eczema [2]
DALTEPARIN Gastrointestinal/Hepatic Cardiovascular
Hepatotoxicity [4] Hypertension [2]
Trade name: Fragmin (Pfizer) Endocrine/Metabolic Hypotension [3]
Indications: Prophylaxis of deep vein thrombosis Pseudomenopause [2] Central Nervous System
Class: Heparin, low molecular weight Weight gain [2] Headache [3]
Half-life: 48 hours Other
Adverse effects [3] Arthralgia [2]
interactions with: butabarbital, danaparoid Death [2]
Pregnancy category: B Back pain (3–4%) [3]
Important contra-indications noted in the Pain in extremities (2%)
pediatric patients DANTROLENE Constipation (2%)
Warning: SPINAL/EPIDURAL HEMATOMA Diarrhea [3]
Trade names: Dantrium (Par), Ryanodex (Eagle)
Nausea (3%) [3]
Indications: Spasticity, malignant hyperthermia
Skin Class: Skeletal muscle relaxant, hydantoin Respiratory
Anaphylactoid reactions/Anaphylaxis Half-life: 8.7 hours Bronchitis [2]
(<10%) [2] Clinically important, potentially hazardous Cough [2]
Bullous dermatitis (<10%) interactions with: verapamil Influenza (2–3%) [2]
Pruritus (<10%) Pregnancy category: C Nasopharyngitis (6–7%) [7]
Rash (<10%) Important contra-indications noted in the Upper respiratory tract infection [5]
Hair prescribing guidelines for: the elderly; nursing Endocrine/Metabolic
Alopecia [2] mothers; pediatric patients Dehydration [2]
Local Warning: HEPATOTOXICITY Hypoglycemia (>10%) [13]
Injection-site hematoma (<10%) Hypovolemia [2]
Litt’s Drug Eruption & Reaction Manual DARATUMUMAB
Genitourinary Gastrointestinal/Hepatic Diarrhea (5%) [2]

Genital mycotic infections (particularly in Hepatitis [3] Hepatotoxicity [3]
women) (3–8%) [32] Hepatotoxicity [2] Nausea (6%) [2]
Pollakiuria [2] Pancreatitis [2] Vomiting (3%)
Urinary frequency (3–4%) Respiratory Respiratory
Urinary tract infection (4–6%) [34] Cough (2%) Cough (<2%)
Renal Eosinophilic pneumonia [2] Dyspnea (2%)
Nephrotoxicity [2] Nasopharyngitis (5%) Eosinophilic pneumonia [15]
Hematologic Pharyngitis (2%) Pharyngolaryngeal pain (8%)
Dyslipidemia (2–3%) Sinusitis (2%) Pneumonia [2]
Upper respiratory tract infection (3%) Endocrine/Metabolic
Other
Adverse effects [9] Hematologic Creatine phosphokinase increased (7%) [6]
Dipsia (thirst) [2] Agranulocytosis [7] Genitourinary
Infection (<10%) Anemia [5] Urinary tract infection (2%)
Hemolysis [6]
Hemolytic anemia [6] Renal
Methemoglobinemia [20] Nephrotoxicity [2]
DAPSONE Local
Renal failure [2]
Application-site erythema (13%) [2] Hematologic
Trade name: Aczone (Allergan) Eosinophilia [2]
Indications: Leprosy, dermatitis herpetiformis, Application-site reactions (18%)
Neutropenia [2]
acne Other Thrombocytopenia [2]
Class: Antibiotic, Antimycobacterial Adverse effects [4]
Half-life: 1050 hours Death [5] Local
Clinically important, potentially hazardous Injection-site reactions (6%)
interactions with: atovaquone/proguanil, Other
chloroquine, didanosine, furazolidone, ganciclovir, DAPTOMYCIN Adverse effects [3]
hydroxychloroquine, methotrexate,
pyrimethamine, rifabutin, rifampin, rifapentine, Trade name: Cubicin (Cubist)
sulfonamides, trimethoprim, ursodiol
Indications: Complicated skin and skin structure DARATUMUMAB
infections, Staphylococcus aureus bloodstream
Important contra-indications noted in the infections Trade name: Darzalex (Janssen Biotech)
prescribing guidelines for: nursing mothers Class: Antibiotic, glycopeptide Indications: Multiple myeloma in patients who
Note: A hypersensitivity reaction – termed the Half-life: ~8 hours have received at least three prior lines of therapy
‘sulfone syndrome’ or ‘dapsone syndrome’ – may Clinically important, potentially hazardous including a proteasome inhibitor (PI) and an
infrequently develop during the first six weeks of interactions with: atorvastatin, cyclosporine, immunomodulatory agent or who are double-
treatment. This syndrome consists of exfoliative fibrates, HMG-CoA reductase inhibitors, refractory to a PI and an immunomodulatory
dermatitis, fever, malaise, nausea, anorexia, rosuvastatin, statins, tobramycin, typhoid vaccine, agent
hepatitis, jaundice, lymphadenopathy and warfarin Class: Monoclonal antibody
hemolytic anemia. Pregnancy category: B Half-life: 18 days
Important contra-indications noted in the Clinically important, potentially hazardous
Skin prescribing guidelines for: the elderly; nursing interactions with: none known
AGEP [2] mothers; pediatric patients Pregnancy category: N/A (No data available)
Bullous dermatitis [2] Important contra-indications noted in the
Cyanosis [2] Skin prescribing guidelines for: pediatric patients
Dapsone syndrome [41] AGEP [2]
DRESS syndrome [14] Cellulitis (<2%) Skin
Erythema multiforme [9] Edema (<7%) Herpes zoster (3%)
Erythema nodosum [5] Fungal dermatitis (3%)
Exanthems (<5%) [12] Mucosal
Hyperhidrosis (5%) Nasal congestion (17%)
Exfoliative dermatitis [10] Pruritus (3–6%)
Fixed eruption [4] Rash (4%) Cardiovascular
Hypersensitivity [21] Chest pain (12%)
Lupus erythematosus [6] Cardiovascular Hypertension (10%)
Photosensitivity [9] Chest pain (7%)
Hypertension (6%) Central Nervous System
Pigmentation [6] Chills (10%)
Rash [6] Hypotension (2%)
Cytokine release syndrome [2]
Stevens-Johnson syndrome [5] Central Nervous System Fever (21%) [3]
Toxic epidermal necrolysis [9] Fever (2%) Headache (12%)
Urticaria [2] Headache (5%)
Insomnia (9%) Neuromuscular/Skeletal
Nails Arthralgia (17%)
Beau’s lines (transverse nail bands) [3] Vertigo (dizziness) (2%)
Central Nervous System Neuromuscular/Skeletal Back pain (23%)
Headache (4%) [2] Back pain (<2%) Pain in extremities (15%)
Insomnia [2] Myalgia/Myopathy [7]
Rhabdomyolysis [7] Gastrointestinal/Hepatic
Peripheral neuropathy [2] Constipation (15%)
Neuromuscular/Skeletal Gastrointestinal/Hepatic Diarrhea (16%)
Asthenia (fatigue) [2] Abdominal pain (<6%) Nausea (27%)
Constipation (6%) Vomiting (14%)
DARATUMUMAB See all our books at www.crcpress.com
Respiratory Local glecaprevir & pibrentasvir, guanfacine,

Bronchospasm (<2%) [3] Injection-site pain (7%) halofantrine, HMG-CoA reductase inhibitors,
Cough (21%) [3] Other indinavir, inhaled corticosteroids, ixabepilone,
Dyspnea (15%) [2] Adverse effects [3] ketoconazole, lidocaine, lopinavir, lovastatin,
Hypoxia (<2%) maraviroc, meperidine, methadone,
Nasopharyngitis (15%) methylprednisolone, midazolam, mifepristone,
Pneumonia (11%) [2] mometasone, nefazodone, nilotinib, nisoldipine,
Rhinitis (>5%) DARIFENACIN olaparib, P-glycoprotein substrates, paricalcitol,
Upper respiratory tract infection (20%) [2] paroxetine hydrochloride, pazopanib,
Trade names: Emselex (Novartis), Enablex phenobarbital, phenytoin, pimecrolimus,
Endocrine/Metabolic (Novartis)
Appetite decreased (15%) pimozide, prasugrel, pravastatin, protease
Indications: Overactive bladder inhibitors, quetiapine, quinidine, quinine,
Hematologic Class: Anticholinergic, Antimuscarinic, Muscarinic ranolazine, rifabutin, rifampin, rilpivirine,
Anemia (45%) [7] antagonist rivaroxaban, romidepsin, rosuvastatin, salmeterol,
Lymphopenia (72%) Half-life: 1319 hours saquinavir, saxagliptin, sertraline, sildenafil,
Neutropenia (60%) [4] Clinically important, potentially hazardous silodosin, simeprevir, simvastatin, sirolimus,
Thrombocytopenia (48%) [7] interactions with: anticholinergics, sorafenib, St John’s wort, tacrolimus, tadalafil,
Local antihistamines, atazanavir, clozapine, tamsulosin, telaprevir, temsirolimus, tenofovir
Infusion-related reactions (48%) [9] cyclosporine, digoxin, disopyramide, disoproxil, terfenadine, theophylline, tolvaptan,
domperidone, erythromycin, flecainide, topotecan, trazodone, triazolam, tricyclic
fosamprenavir, haloperidol, imipramine, indinavir, antidepressants, vardenafil, voriconazole,
itraconazole, ketoconazole, levodopa, lopinavir, warfarin, zidovudine
DARBEPOETIN ALFA MAO inhibitors, memantine, metoclopramide, Pregnancy category: C
nefopam, nelfinavir, nitrates (sublingual), Important contra-indications noted in the
Synonym: erythropoiesis stimulating protein parasympathomimetics, paroxetine prescribing guidelines for: nursing mothers;
Trade name: Aranesp (Amgen) hydrochloride, phenothiazines, potent CYP3A4 pediatric patients
Indications: Anemia associated with renal failure inhibitors, ritonavir, saquinavir, thioridazine, Note: Darunavir is a sulfonamide and can be
and chemotherapy tipranavir, tricyclic antidepressants, verapamil absorbed systemically. Sulfonamides can produce
Class: Colony stimulating factor, Erythropoiesis- Pregnancy category: C severe, possibly fatal, reactions such as toxic
stimulating agent (ESA), Erythropoietin Important contra-indications noted in the epidermal necrolysis and Stevens-Johnson
Half-life: 21 hours prescribing guidelines for: nursing mothers; syndrome.
Clinically important, potentially hazardous pediatric patients Prezcobix is darunavir and cobicistat.
interactions with: none known Note: Contra-indicated in patients with, or at risk
Pregnancy category: C for, urinary retention, gastric retention or
Important contra-indications noted in the uncontrolled narrow-angle glaucoma. Skin
prescribing guidelines for: nursing mothers; Angioedema (<2%)
pediatric patients Hypersensitivity (<2%) [2]
Note: There is an increased risk of death for Mucosal Pruritus (<2%)
patients suffering from chronic renal failure with Xerostomia (20%) [12] Rash (6–10%) [9]
this drug (6%). Central Nervous System Stevens-Johnson syndrome (<2%)
Warning: ERYTHROPOIESIS-STIMULATING Headache [2] Urticaria (<2%)
AGENTS (ESAs) INCREASE THE RISK OF Gastrointestinal/Hepatic Central Nervous System
DEATH, MYOCARDIAL INFARCTION, Abdominal pain (2%) Abnormal dreams (<2%)
STROKE, VENOUS THROMBOEMBOLISM, Constipation [3] Anorexia (2%)
THROMBOSIS OF VASCULAR ACCESS AND Headache (7%) [6]
TUMOR PROGRESSION OR RECURRENCE
Skin
DARUNAVIR Asthenia (fatigue) (2–3%)
Osteonecrosis (<2%)
Edema (21%) Trade names: Prezcobix (Janssen), Prezista
Peripheral edema (11%) Gastrointestinal/Hepatic
(Janssen) Abdominal distension (2%)
Pruritus (8%) Indications: HIV infection (must be co-
Rash (7%) [2] Abdominal pain (6%)
administered with ritonavir and with other Diarrhea (9–14%) [10]
Central Nervous System antiretroviral agents) Dyspepsia (<3%)
Fever (919%) Class: Antiretroviral, HIV-1 protease inhibitor Flatulence (<2%)
Vertigo (dizziness) (814%) Half-life: 15 hours Gastrointestinal disorder [3]
Neuromuscular/Skeletal Clinically important, potentially hazardous Hepatotoxicity (<2%) [6]
Arthralgia (1113%) interactions with: abacavir, alfuzosin, Nausea (4–7%) [6]
Asthenia (fatigue) (933%) almotriptan, alosetron, alprazolam, amiodarone, Pancreatitis (<2%)
Back pain (8%) antifungals, apixaban, artemether/lumefantrine, Vomiting (2–5%)
Myalgia/Myopathy (21%) astemizole, atorvastatin, bortezomib,
brinzolamide, calcium channel blockers, captopril, Endocrine/Metabolic
Gastrointestinal/Hepatic carbamazepine, ciclesonide, cisapride, Diabetes mellitus (new onset or exacebated)
Abdominal pain (12%) clarithromycin, colchicine, conivaptan, (2%)
Respiratory cyclosporine, CYP2D6 substrates, CYP3A4 Other
Cough (10%) inhibitors, inducers and substrates, dabigatran, Adverse effects [6]
Flu-like syndrome (6%) dasatinib, deferasirox, delavirdine, didanosine,
Upper respiratory tract infection (14%) dienogest, digoxin, dihydroergotamine,
Hematologic dronedarone, duloxetine, dutasteride, efavirenz,
elbasvir & grazoprevir, enfuvirtide, eplerenone,
Thrombosis [2]
ergotamine, estrogens, etravirine, everolimus,
fentanyl, fesoterodine, food, fusidic acid,
Litt’s Drug Eruption & Reaction Manual DASATINIB
atorvastatin, boceprevir, cabazitaxel, Vertigo (dizziness) (<10%)

DASABUVIR/ carbamazepine, chloroquine, ciclesonide, Neuromuscular/Skeletal
cilostazol, cinacalcet, ciprofloxacin, cisapride,
OMBITASVIR/PARITA- clarithromycin, clopidogrel, clozapine, colchicine,
Arthralgia (<19%)
PREVIR/RITONAVIR conivaptan, cyclosporine, CYP3A4 inhibitors,
inducers and substrates, dabigatran, darunavir,
Bone or joint pain (12–19%) [3]
Myalgia/Myopathy (6–13%) [2]
Trade name: Viekira XR (AbbVie) deferasirox, dexamethasone, dihydroergotamine,
docetaxel, dronedarone, efavirenz, eptifibatide, Gastrointestinal/Hepatic
Indications: Genotype 1a chronic hepatitis C Abdominal distension (<10%)
virus with or without cirrhosis, genotype 1b ergotamine, erythromycin, eszopiclone,
famotidine, fentanyl, fesoterodine, gadobutrol, Abdominal pain (<25%) [2]
chronic hepatitis C virus with or without cirrhosis Colitis (<10%) [3]
in combination with ribavirin gefitinib, H2 antagonists, indinavir, itraconazole,
ixabepilone, ketoconazole, lopinavir, lurasidone, Constipation (<10%)
Class: CYP3A4 inhibitor (ritonavir), Direct-acting Diarrhea (18–31%) [19]
antiviral, Hepatitis C virus non-nucleoside NS5B maraviroc, meloxicam, nefazodone, nelfinavir,
nilotinib, omeprazole, pantoprazole, Dyspepsia (<10%)
palm polymerase inhibitor (dasabuvir), Hepatitis Enterocolitis (<10%)
C virus NS3/4A protease inhibitor (paritaprevir), phenobarbital, phenytoin, pimozide, proton
pump inhibitors, QT prolonging agents, quinidine, Gastritis (<10%)
Hepatitis C virus NS5A inhibitor (ombitasvir) Gastrointestinal bleeding (2–8%) [3]
Half-life: 6 hours (dasabuvir); 21–25 hours quinine, rifampin, ritonavir, saquinavir, saxagliptin,
sildenafil, simvastatin, sirolimus, St John’s wort, Hemorrhagic colitis [2]
(ombitasvir); 6 hours (paritaprevir); 4 hours Hepatitis [2]
(ritonavir) tacrolimus, tadalafil, temsirolimus, terfenadine,
tetrabenazine, thioridazine, tiagabine, tinzaparin, Hepatotoxicity [2]
Clinically important, potentially hazardous Nausea (9–23%) [11]
interactions with: alfuzosin, carbamazepine, vardenafil, ziprasidone
Pregnancy category: D Vomiting (7–15%) [6]
cisapride, copanlisib, dihydroergotamine,
dronedarone, efavirenz, ergotamine, ethinyl Important contra-indications noted in the Respiratory
estradiol-containing medications, gemfibrozil, prescribing guidelines for: nursing mothers; Cough (<10%)
lovastatin, lurasidone, methylergonovine, pediatric patients Dyspnea (20%) [5]
midazolam, midostaurin, neratinib, phenobarbital, Pleural effusion (12–21%) [38]
phenytoin, pimozide, ranolazine, rifampin, Skin Pneumonia (<10%) [3]
sildenafil, simvastatin, St John’s wort, triazolam Acneform eruption (<10%) [2] Pneumonitis (<10%)
Pregnancy category: N/A (Insufficient evidence Dermatitis (<10%) Pulmonary hypertension (<10%) [11]
to inform drug-associated risk; contra-indicated in Eczema (<10%) Pulmonary toxicity [3]
pregnancy when given with ribavirin) Edema (13–18%) [6] Upper respiratory tract infection (<10%)
Important contra-indications noted in the Erythema [2] Endocrine/Metabolic
prescribing guidelines for: nursing mothers; Herpes (<10%) Weight gain (<10%)
pediatric patients Hyperhidrosis (<10%) Weight loss (<10%)
Note: Contra-indicated in patients with Panniculitis [4] Renal
moderate to severe hepatic impairment. See also Peripheral edema [3] Proteinuria [2]
separate entries for Ombitasvir/Paritaprevir/ Pruritus (<10%) [4] Renal failure [3]
Ritonavir (co-packaged with Dasabuvir as Viekira Rash (11–21%) [10]
Pak) and Ribavirin. Toxicity [7] Hematologic
Urticaria (<10%) Anemia [3]
Xerosis (<10%) Bleeding (6–26%)
Skin Cytopenia [3]
Pruritus (7%) [2] Hair Febrile neutropenia (<12%)
Rash (7%) Alopecia (<10%) [3] Hemorrhage [2]
Central Nervous System Hair pigmentation [2] Hemotoxicity [4]
Insomnia (5%) [2] Mucosal Myelosuppression [9]
Neuromuscular/Skeletal Mucositis (16%) Neutropenia [7]
Asthenia (fatigue) (4%) [3] Cardiovascular Pancytopenia (<10%)
Arrhythmias (<10%) Thrombocytopenia [13]
Hepatotoxicity [2] Cardiac failure (3%) Otic
Nausea (8%) Congestive heart failure (2%) Tinnitus (<10%)
Flushing (<10%) Ocular
Endocrine/Metabolic Hypertension (<10%)
ALT increased [2] Reduced visual acuity (<10%)
Palpitation (<10%) Vision blurred (<10%)
Hyperbilirubinemia (2%) Pericardial effusion (2–3%) [6] Visual disturbances (<10%)
QT prolongation [3] Xerophthalmia (<10%)
Tachycardia (<10%)
DASATINIB Central Nervous System
Other
Adverse effects [4]
Anorexia (<10%) [6] Death [2]
Trade name: Sprycel (Bristol-Myers Squibb) Anxiety [2]
Indications: Leukemia (chronic myeloid), acute Infection (<14%) [2]
Depression (<10%) Side effects [2]
lymphoblastic leukemia Dysgeusia (taste perversion) (<10%)
Class: Antineoplastic, Biologic, Tyrosine kinase Fever (5–39%)
inhibitor Headache (12–33%) [8]
Half-life: 3–5 hours Insomnia (<10%)
Clinically important, potentially hazardous Neurotoxicity (13%)
interactions with: abciximab, alfentanil, Pain (26%) [2]
alfuzosin, ambrisentan, antacids, anticoagulants, Peripheral neuropathy (<10%)
antiplatelet agents, aprepitant, argatroban, Somnolence (drowsiness) (<10%)
artemether/lumefantrine, astemizole, atazanavir, Subdural hemorrhage [4]
DAUNORUBICIN Over 100 updates per week on www.drugeruptiondata.com
DAUNORUBICIN Arthralgia (7%) DECITABINE
Synonyms: daunomycin; DNR; rubidomycin Ataxia (<5%) Synonym: 5-aza-2’-deoxycytidine
Trade name: DaunoXome (Gilead) Back pain (16%) Trade name: Dacogen (MGI Pharma)
Indications: Acute leukemias Hyperkinesia (<5%) Indications: Myelodysplastic syndromes,
Class: Antibiotic, anthracycline Hypertonia (<5%) leukemia
Half-life: 14–20 hours; 4 hours (intramuscular) Myalgia/Myopathy (7%) Class: Antineoplastic
Clinically important, potentially hazardous Half-life: ~30 minutes
interactions with: aldesleukin, gadobenate Gastrointestinal/Hepatic Clinically important, potentially hazardous
Pregnancy category: D Abdominal pain (23%) interactions with: none known
Important contra-indications noted in the Black stools (<5%) Pregnancy category: D
prescribing guidelines for: the elderly; nursing Constipation (7%) Important contra-indications noted in the
mothers; pediatric patients Diarrhea (38%) prescribing guidelines for: nursing mothers;
Warning: MYOCARDIAL TOXICITY / Dysphagia (<5%) pediatric patients
MYELOSUPPRESSION Gastritis (<5%)
Gastrointestinal bleeding (<5%)
Hemorrhoids (<5%) Skin
Skin Hepatomegaly (<5%) Bacterial infection (5%)
Angioedema [4] Nausea (54%) Candidiasis (10%)
Dermatitis [2] Tenesmus (5%) Cellulitis (12%)
Edema (11%) Vomiting (23%) Ecchymoses (22%)
Exanthems [2] Edema (18%)
Folliculitis (<5%) Respiratory Erythema (14%)
Hot flashes (<5%) Cough (28%) Facial edema (6%)
Hyperhidrosis (14%) Dyspnea (26%) Hematoma (5%)
Lymphadenopathy (<5%) Flu-like syndrome (5%) Lymphadenopathy (12%)
Neutrophilic eccrine hidradenitis [2] Hemoptysis (<5%) Pallor (23%)
Pigmentation [3] PIE syndrome (<5%) Peripheral edema (25%)
Pruritus (7%) Rhinitis (12%) Petechiae (39%)
Seborrhea (<5%) Sinusitis (8%) Pruritus (11%)
Urticaria [3] Endocrine/Metabolic Rash (19%) [2]
Xerosis (<5%) Appetite increased (<5%) Urticaria (6%)
Hair Dehydration (<5%) Mucosal
Alopecia (8%) [4] Genitourinary Gingival bleeding (8%)
Nails Dysuria (<5%) Glossodynia (5%)
Nail pigmentation [5] Nocturia (<5%) Lip ulceration (5%)
Polyuria (<5%) Mucositis [2]
Mucosal Oral candidiasis (6%)
Gingival bleeding (<5%) Hematologic
Neutropenia (15–36%) Stomatitis (12%)
Oral lesions [2] Tongue ulceration (7%)
Sialorrhea (<5%) Splenomegaly (<5%)
Stomatitis (10%) Otic Cardiovascular
Xerostomia (<5%) Ear pain (<5%) Chest pain (7%)
Hearing loss (<5%) Hypotension (6%)
Cardiovascular Pulmonary edema (6%)
Chest pain (9–14%) Tinnitus (<5%)
QT prolongation [2]
Flushing (14%) Ocular
Hypertension (<5%) Abnormal vision (5%) Central Nervous System
Myocardial toxicity [5] Conjunctivitis (<5%) Anorexia (16%) [2]
Palpitation (<5%) Ocular pain (<5%) Anxiety (11%)
Tachycardia (<5%) Confusion (12%)
Local Fever (53%) [2]
Central Nervous System Injection-site inflammation (<5%) Headache (28%)
Amnesia (<5%) Injection-site necrosis (<10%) [2] Hypoesthesia (11%)
Anorexia (23%) Injection-site ulceration (<10%) Insomnia (28%)
Anxiety (<5%) Other Pain (13%)
Cognitive impairment (<5%) Dipsia (thirst) (<5%) Rigors (22%)
Depression (10%) Hiccups (<5%) Vertigo (dizziness) (18%)
Dysgeusia (taste perversion) (<5%) Infection (40%)
Gait instability (<5%) Neuromuscular/Skeletal
Tooth decay (<5%) Arthralgia (20%)
Hallucinations (<5%)
Headache (25%) Asthenia (fatigue) (5–12%) [6]
Insomnia (6%) Back pain (17%)
Meningococcal infection (<5%) Bone or joint pain (6–19%)
Neurotoxicity (13%) Myalgia/Myopathy (5%)
Rigors (19%) Gastrointestinal/Hepatic
Seizures (<5%) Abdominal distension (5%)
Somnolence (drowsiness) (<5%) Abdominal pain (14%)
Syncope (<5%) Ascites (10%)
Tremor (<5%) Constipation (35%)
Vertigo (dizziness) (8%) Diarrhea (34%) [2]
Dyspepsia (12%)
Litt’s Drug Eruption & Reaction Manual DEFEROXAMINE
Dysphagia (6%) repaglinide, rifampin, ritonavir, sildenafil, Central Nervous System

Gastroesophageal reflux (5%) telithromycin, theophylline, tiagabine, tipranavir, Headache (3%)
Hemorrhoids (8%) trimethoprim, ulipristal Neuromuscular/Skeletal
Hepatotoxicity [2] Pregnancy category: C Arthralgia (10%) [8]
Loose stools (7%) Important contra-indications noted in the Arthropathy [5]
Nausea (42%) [7] prescribing guidelines for: the elderly; nursing Back pain (2%)
Vomiting (25%) [4] mothers Bone or joint pain [2]
Respiratory Warning: RENAL FAILURE, HEPATIC FAILURE, Pain in extremities (2%)
Cough (40%) AND GASTROINTESTINAL HEMORRHAGE
Hypoxia (10%) Abdominal pain (10%) [2]
Pharyngitis (16%) Skin Diarrhea (3%) [2]
Pneumonia (22%) [2] Rash (2–11%) [24] Dyspepsia (2%)
Sinusitis (5%) Urticaria (4%) Gastrointestinal disorder [5]
Endocrine/Metabolic Central Nervous System Hepatotoxicity [3]
ALP increased (11%) Headache (16%) [2] Nausea (13%) [4]
Appetite decreased (16%) Neuromuscular/Skeletal Vomiting (10%)
AST increased (10%) Arthralgia (7%) Endocrine/Metabolic
Dehydration (6%) Asthenia (fatigue) [3] ALT increased (8%) [5]
Hyperglycemia (33%) Back pain (6%) Appetite increased (4%)
Hyperkalemia (13%) AST increased [2]
Hypoalbuminemia (24%) Gastrointestinal/Hepatic
Abdominal pain (21–28%) [12] Weight gain (2%)
Hypokalemia (22%)
Hypomagnesemia (24%) Diarrhea (5–20%) [18] Renal
Hyponatremia (19%) Gastrointestinal bleeding [3] Chromaturia (15%)
Gastrointestinal disorder [3] Hematologic
Genitourinary Hepatotoxicity [8]
Dysuria (6%) Agranulocytosis (2%) [15]
Nausea (2–6%) [20] Neutropenia [12]
Urinary frequency (5%) Vomiting (10–21%) [7]
Urinary tract infection (7%) Thrombocytopenia [2]
Respiratory Other
Hematologic Cough (14%)
Anemia (82%) [5] Adverse effects [2]
Flu-like syndrome (11%) Death [2]
Bacteremia (5%) Upper respiratory tract infection (9%)
Febrile neutropenia (29%) [7]
Hemotoxicity [2] Endocrine/Metabolic
ALT increased [8]
Leukopenia (28%)
Appetite decreased [2]
DEFEROXAMINE
Lymphopenia [2]
Myelosuppression [11] AST increased [3] Trade name: Desferal (Novartis)
Neutropenia (90%) [12] Serum creatinine increased [21] Indications: Hemochromatosis, acute iron
Thrombocytopenia (89%) [8] Renal overload
Ocular Fanconi syndrome [10] Class: Chelator, iron
Vision blurred (6%) Nephrotoxicity [7] Half-life: 6.1 hours
Proteinuria [4] Clinically important, potentially hazardous
Local Renal failure [3] interactions with: ascorbic acid, ferrous sulfate,
Injection-site edema (5%) Renal function abnormal [2] zinc
Injection-site erythema (5%) Pregnancy category: C
Other
Adverse effects [2] Skin
Allergic reactions [2] Anaphylactoid reactions/Anaphylaxis [3]
Infection [3]
DEFERIPRONE Hypersensitivity [2]
Trade name: Ferriprox (ApoPharma) Neurotoxicity [2]
DEFERASIROX Indications: Treatment of patients with Neuromuscular/Skeletal
transfusional iron overload due to thalassemia Arthralgia [6]
Trade names: Exjade (Novartis), Jadenu syndromes when current chelation therapy is
(Novartis) inadequate Endocrine/Metabolic
Indications: Chronic iron overload due to blood Class: Chelator, iron Serum creatinine increased [2]
transfusions and in non-transfuson dependent Half-life: 1.9 hours Otic
thalassemia syndromes Clinically important, potentially hazardous Hearing loss [2]
Class: Chelator, iron interactions with: antacids containing iron, Ototoxicity [7]
Half-life: 816 hours aluminum, zinc, diclofenac, mineral supplements,
Clinically important, potentially hazardous Ocular
probenecid
interactions with: alfuzosin, aluminum- Night blindness [2]
containing antacids, ambrisentan, aprepitant, Retinopathy [12]
cabazitaxel, cholestyramine, cilostazol, prescribing guidelines for: the elderly; nursing Local
colesevelam, colestipol, conivaptan, dabigatran, mothers; pediatric patients Injection-site inflammation (<10%)
darunavir, dasatinib, delavirdine, docetaxel, Warning: AGRANULOCYTOSIS / Injection-site pain (<10%)
efavirenz, enalapril, estradiol, eszopiclone, NEUTROPENIA Other
fesoterodine, gefitinib, indinavir, ixabepilone,
Death [3]
lapatinib, lurasidone, maraviroc, pazopanib,
phenobarbital, phenytoin, pioglitazone,
DEFIBROTIDE See all our books at www.crcpress.com
Erythema (8%) Irritation (<2%)

DEFIBROTIDE Hypersensitivity [3] Pruritus (<2%)
Toxic epidermal necrolysis [2] Rash (<2%)
Trade name: Defitelio (Jazz) Urticaria (<2%)
Indications: Hepatic veno-occlusive disease in Hair
patients with renal or pulmonary dysfunction Hirsutism (10%) [2] Mucosal
following hematopoietic stem-cell transplantation Mucosal Oral candidiasis (<2%)
Class: Oligonucleotide Rhinorrhea (8%) Cardiovascular
Half-life: <2 hours Central Nervous System Bradycardia (<2%)
Clinically important, potentially hazardous Behavioral disturbances [2] Flushing (<2%)
interactions with: alteplase, heparin Irritability (8%) Hypertension (<2%)
Pregnancy category: N/A (No data available) Hypotension (<2%)
Important contra-indications noted in the Gastrointestinal/Hepatic Palpitation (<2%)
prescribing guidelines for: nursing mothers Abdominal pain (6%) Phlebitis (<2%)
Note: Contra-indicated for concomitant Respiratory Tachycardia (<2%)
administration with systemic anticoagulant or Cough (12%) Central Nervous System
fibrinolytic therapy. Nasopharyngitis (10%) Abnormal dreams (<2%)
Upper respiratory tract infection (12%) Anxiety (<2%)
Skin Endocrine/Metabolic Dysgeusia (taste perversion) (<2%)
Graft-versus-host reaction (6%) Appetite increased (14%) [2] Headache (3%) [2]
Mucosal Weight gain (20%) [5] Hypoesthesia (<2%)
Epistaxis (nosebleed) (14%) Genitourinary Insomnia (<2%)
Pollakiuria (12%) Paresthesias (<2%)
Cardiovascular Presyncope (<2%)
Hypotension (37%) [3] Ocular Syncope (<2%)
Central Nervous System Cataract [3] Vertigo (dizziness) (<2%)
Cerebral hemorrhage (2%) Other Neuromuscular/Skeletal
Intracranial hemorrhage (3%) Adverse effects [2] Myalgia/Myopathy (<2%)
Gastrointestinal/Hepatic Side effects [2]
Diarrhea (24%) Abdominal pain (<2%)
Gastrointestinal bleeding (9%) [3] Diarrhea (8%) [4]
Nausea (16%) DEGARELIX Dyspepsia (<2%)
Vomiting (18%) Nausea (8%) [3]
Respiratory See: www.drugeruptiondata.com/drug/id/1362 Vomiting (2%) [2]
Alveolar hemorrhage (pulmonary) (9%) Endocrine/Metabolic
Pneumonia (5%) ALT increased (>2%)
Pulmonary hemorrhage (4%) DELAFLOXACIN * AST increased (>2%)
Pulmonary toxicity (6%) Creatine phosphokinase increased (<2%)
Endocrine/Metabolic Trade name: Baxdela (Melinta) Hyperglycemia (<2%)
Hyperuricemia (2%) Indications: Acute bacterial skin and skin Hyperphosphatemia (<2%)
structure infections caused by designated Hypoglycemia (<2%)
Hematologic susceptible bacteria
Hemorrhage [2] Serum creatinine increased (<2%)
Class: Antibiotic, fluoroquinolone
Sepsis (7%) Half-life: 4–9 hours Genitourinary
Other Clinically important, potentially hazardous Vulvovaginal candidiasis (<2%)
Adverse effects [3] interactions with: none known Renal
Infection (3%) Pregnancy category: N/A (Insufficient evidence Nephrotoxicity (<2%)
to inform drug-associated risk) Renal failure (<2%)
Important contra-indications noted in the Hematologic
DEFLAZACORT * mothers; pediatric patients
Thrombosis (<2%)
Note: Fluoroquinolones are associated with an Otic
Trade name: Emflaza (Marathon) Tinnitus (<2%)
Indications: Duchenne muscular dystrophy increased risk of tendinitis and tendon rupture in
Class: Corticosteroid all ages. This risk is further increased in older Ocular
Half-life: N/A patients usually over 60 years of age, in patients Vision blurred (<2%)
Clinically important, potentially hazardous taking corticosteroid drugs, and in patients with Local
interactions with: carbamazepine, kidney, heart or lung transplants. Injection-site bruising (<2%)
clarithromycin, diltiazem, efavirenz, fluconazole, Fluoroquinolones may exacerbate muscle Injection-site extravasation (<2%)
grapefruit juice, live vaccines, pancuronium, weakness in persons with myasthenia gravis.
Warning: SERIOUS ADVERSE REACTIONS Other
phenytoin, rifampin, verapamil Infection (<2%)
Pregnancy category: N/A (Should be used INCLUDING TENDINITIS, TENDON
during pregnancy only if the potential benefit RUPTURE, PERIPHERAL NEUROPATHY,
justifies the potential risk to the fetus) CENTRAL NERVOUS SYSTEM EFFECTS, and
Important contra-indications noted in the EXACERBATION OF MYASTHENIA GRAVIS DELAVIRDINE
mothers; pediatric patients Skin See: www.drugeruptiondata.com/drug/id/199
Dermatitis (<2%)
Skin Edema (<2%)
Cushingoid features (33%) [2] Erythema (<2%)
Hypersensitivity (<2%)
Litt’s Drug Eruption & Reaction Manual DESMOPRESSIN
Pneumonia (4%)
DEMECLOCYCLINE Upper respiratory tract infection (5%) DESIPRAMINE
See: www.drugeruptiondata.com/drug/id/200 Endocrine/Metabolic See: www.drugeruptiondata.com/drug/id/202
Hypercholesterolemia (7%) [2]
Hypocalcemia (2%) [34]
DENILEUKIN Genitourinary
DESLORATADINE
See: www.drugeruptiondata.com/drug/id/201 Cystitis (6%) Trade name: Clarinex (Schering)
Hematologic Indications: Allergic rhinitis, urticaria
Anemia (3%) [2] Class: Histamine H1 receptor antagonist
DENOSUMAB Other Half-life: 27 hours
Trade names: Prolia (Amgen), Xgeva (Amgen) Infection [12] interactions with: none known
Indications: Osteoporosis (postmenopausal Pregnancy category: C
women), prevention of skeletal-related events in Important contra-indications noted in the
patients with bone metastases from solid tumors
Class: Bone resorption inhibitor, Monoclonal
DEOXYCHOLIC ACID pediatric patients
antibody, RANK ligand (RANKL) inhibitor Trade name: Kybella (Kythera)
Half-life: 25–28 days Indications: Improvement in the appearance of Skin
Clinically important, potentially hazardous moderate to severe convexity or fullness Urticaria [2]
interactions with: abatacept, alcohol, associated with submental fat Mucosal
azacitidine, betamethasone, cabazitaxel, Class: Cytolytic Xerostomia [5]
denileukin, docetaxel, fingolimod, gefitinib, Half-life: N/A
immuosuppressants, leflunomide, lenalidomide, Central Nervous System
Clinically important, potentially hazardous Headache [7]
oxaliplatin, pazopanib, temsirolimus, interactions with: none known
triamcinolone Somnolence (drowsiness) [6]
Pregnancy category: X Important contra-indications noted in the Neuromuscular/Skeletal
Important contra-indications noted in the prescribing guidelines for: the elderly; pediatric Asthenia (fatigue) [7]
prescribing guidelines for: nursing mothers; patients Gastrointestinal/Hepatic
pediatric patients Note: Contra-indicated in the presence of Diarrhea [2]
Note: Contra-indicated in patients with infection at the injection sites. Nausea [2]
hypocalcemia.
Other
Skin Adverse effects [6]
Skin Lymphadenopathy (<2%)
Cellulitis [9]
Dermatitis [2] Mucosal
Eczema [10] Oropharyngeal pain (3%) DESMOPRESSIN
Herpes zoster (2%) Cardiovascular
Hypersensitivity [2] Hypertension (3%) Trade names: DDAVP (Sanofi-Aventis), Minirin
Peripheral edema (5%) (Ferring), Noctiva (Serenity), Stimate (CSL
Central Nervous System Behring)
Pruritus (2%) Headache (8%)
Rash (3%) [4] Indications: Primary nocturnal enuresis, nocturia
Syncope (<2%) due to nocturnal polyuria (Noctiva)
Cardiovascular Neuromuscular/Skeletal Class: Antidiuretic hormone analog
Angina (3%) Neck pain (<2%) Half-life: 75 minutes
Atrial fibrillation (2%) Clinically important, potentially hazardous
Cardiotoxicity [2] Gastrointestinal/Hepatic
Dysphagia (2%) interactions with: amitriptyline, citalopram,
Central Nervous System Nausea (2%) demeclocycline, hydromorphone, meloxicam,
Headache [3] tapentadol
Insomnia (3%) Local Pregnancy category: B
Pain [2] Injection-site bruising (72%) [2] Important contra-indications noted in the
Vertigo (dizziness) (5%) Injection-site edema [2] prescribing guidelines for: the elderly; nursing
Injection-site erythema (27%) mothers; pediatric patients
Neuromuscular/Skeletal Injection-site hemorrhage (<2%)
Arthralgia [3] Warning: Noctiva: HYPONATREMIA
Injection-site induration (23%) [2]
Asthenia (fatigue) (2%) [2] Injection-site nodules (13%)
Back pain (35%) [6] Injection-site numbness (66%) [2] Cardiovascular
Bone or joint pain (4–8%) [3] Injection-site pain (70%) [2] Flushing (<10%)
Fractures [8] Injection-site pigmentation (<2%) Myocardial infarction [2]
Myalgia/Myopathy (3%) Injection-site pruritus (12%) Central Nervous System
Osteonecrosis (jaw) [25] Injection-site urticaria (<2%) Headache [6]
Pain in extremities (12%) [6] Seizures [5]
Other
Gastrointestinal/Hepatic Adverse effects [2] Endocrine/Metabolic
Abdominal pain (3%) Hyponatremia [11]
Flatulence (2%) SIADH [2]
Gastroesophageal reflux (2%)
Pancreatitis [2] DESFLURANE Local
Injection-site pain (<10%)
Respiratory See: www.drugeruptiondata.com/drug/id/920
Pharyngitis (2%)
DESONIDE Over 100 updates per week on www.drugeruptiondata.com
Impaired concentration (<2%) Insomnia (7%) [2]

DESONIDE Insomnia (912%) [3] Somnolence (drowsiness) (11%) [4]
Irritability (2%) Vertigo (dizziness) (4%)
See: www.drugeruptiondata.com/drug/id/1084 Nervousness (<2%) [2] Neuromuscular/Skeletal
Paresthesias (<3%) Asthenia (fatigue) (9%) [3]
Seizures (~2%)
DESOXIMETASONE Somnolence (drowsiness) (4–12%) [4] Gastrointestinal/Hepatic
Suicidal ideation [2] Constipation (4%)
Trade name: Topicort (Taro) Syncope (<2%) Diarrhea (9%) [2]
Indications: Dermatoses Tremor (~3%) Genitourinary
Class: Corticosteroid, topical Vertigo (dizziness) (10–16%) [5] Urinary tract infection (7%)
Half-life: N/A Yawning (<4%)
interactions with: live vaccines
Asthenia (fatigue) (7–11%) [2] DEXAMETHASONE
Important contra-indications noted in the Gastrointestinal/Hepatic
Constipation (9–14%) Trade names: Decadron (Merck), Dexone
prescribing guidelines for: nursing mothers; (Solvay), Ozurdex (Allergan)
pediatric patients Diarrhea (5–11%)
Nausea (22–41%) [6] Indications: Antiemetic, arthralgias, dermatoses,
Vomiting (3–9%) diagnostic aid, macular edema following branch
Local retinal vein occlusion (BRVO) or central retinal
Application-site irritation (3%) Endocrine/Metabolic vein occlusion (CRVO), non-infectious uveitis
Application-site pruritus (2%) [2] Appetite decreased (5–10%) affecting the posterior segment of the eye
Libido decreased (3–6%) Class: Antiemetic, Corticosteroid, systemic,
Other Weight gain (<2%)
Adverse effects [3] Corticosteroid, topical
Weight loss (<2%) Half-life: N/A
Genitourinary Clinically important, potentially hazardous
Ejaculatory dysfunction (<5%) interactions with: albendazole,
DESVENLAFAXINE Erectile dysfunction (3–11%) aminoglutethimide, amprenavir, aprepitant,
Sexual dysfunction (<2%) aspirin, bexarotene, boceprevir, carbamazepine,
Trade name: Pristiq (Wyeth) caspofungin, cobicistat/elvitegravir/emtricitabine/
Indications: Major depressive disorder Otic
Tinnitus (<2%) tenofovir alafenamide, cobicistat/elvitegravir/
Class: Antidepressant, Serotonin-norepinephrine emtricitabine/tenofovir disoproxil,
reuptake inhibitor Ocular cyclophosphamide, dasatinib, delavirdine,
Half-life: 11 hours Mydriasis (2–6%) diuretics, ephedrine, imatinib, itraconazole,
Clinically important, potentially hazardous Vision blurred (34%) ixabepilone, lapatinib, lenalidomide, live vaccines,
interactions with: alcohol, aspirin, CNS-active lopinavir, methotrexate, midazolam,
agents, heparin, ketoconazole, linezolid, lithium, phenobarbital, phenytoin, praziquantel,
MAO inhibitors, NSAIDs, sibutramine, tramadol,
venlafaxine, warfarin
DEUTETRABENAZINE * primidone, rifampin, rilpivirine, romidepsin,
simeprevir, sorafenib, sunitinib, telaprevir,
Pregnancy category: C Trade name: Austedo (Teva) temsirolimus, ticagrelor, vandetanib, warfarin
Important contra-indications noted in the Indications: Chorea associated with Pregnancy category: C
prescribing guidelines for: the elderly; nursing Huntington’s disease Important contra-indications noted in the
mothers; pediatric patients Class: Vesicular monoamine transporter 2 prescribing guidelines for: nursing mothers;
Warning: SUICIDAL THOUGHTS AND inhibitor pediatric patients
BEHAVIORS Half-life: 9–10 hours
Skin interactions with: alcohol or other sedating Acneform eruption [6]
Hot flashes (<2%) drugs, bupropion, dopamine antagonists or AGEP [2]
Hyperhidrosis (10–21%) antipsychotics, fluoxetine, MAO inhibitors, Anaphylactoid reactions/Anaphylaxis [3]
Hypersensitivity (2%) paroxetine hydrochloride, quinidine, strong Dermatitis [5]
Rash (<2%) CYP2D6 inhibitors, tetrabenazine Edema [4]
Mucosal Pregnancy category: N/A (Based on animal Erythema multiforme [3]
Epistaxis (nosebleed) (<2%) data, may cause fetal harm) Exanthems [4]
Xerostomia (11–25%) [3] Important contra-indications noted in the Herpes zoster [2]
prescribing guidelines for: the elderly; nursing Hyperhidrosis [2]
Cardiovascular mothers; pediatric patients
Hypertension (<2%) Hypersensitivity [5]
Note: Contra-indicated in suicidal or untreated/ Peripheral edema [8]
Hypotension (~2%) inadequately treated depression, in hepatic
Orthostatic hypotension (<2%) Pigmentation [2]
impairment. or in patients taking MAO inhibitors, Pruritus [7]
Palpitation (<3%) reserpine or tetrabenazine.
Tachycardia (<2%) Pruritus ani et vulvae [2]
Warning: DEPRESSION AND SUICIDALITY Rash [10]
Central Nervous System Striae [4]
Abnormal dreams (2–4%) Skin Toxicity [5]
Anorexia (58%) [2] Hematoma (4%) Tumor lysis syndrome [3]
Anorgasmia (3–8%) Xerosis [2]
Anxiety (35%) Mucosal
Chills (<4%) Xerostomia (9%) Mucosal
Dysgeusia (taste perversion) (<2%) Central Nervous System Oral candidiasis [2]
Extrapyramidal symptoms (<2%) Anxiety (4%) [2] Cardiovascular
Headache (20–29%) [3] Depression [3] Bradycardia [8]
Litt’s Drug Eruption & Reaction Manual DEXRAZOXANE
Flushing [5] Otic Cardiovascular

Hypertension [16] Ototoxicity [4] Cardiac disorder (<2%)
Myocardial toxicity [11] Ocular Central Nervous System
Tachycardia [2] Cataract (<10%) [7] Headache [2]
Thromboembolism [3] Conjunctival hemorrhage (>10%)
Venous thromboembolism [5] Gastrointestinal/Hepatic
Glaucoma [9] Abdominal pain (4%) [4]
Central Nervous System Intraocular pressure increased (>10%) [10] Constipation [2]
Anorexia [2] Ocular hypertension (<10%) [6] Diarrhea (5%) [4]
Catatonia [2] Ocular pain (<10%) [6] Flatulence (<3%) [3]
Dysgeusia (taste perversion) [3] Vision blurred [3] Gastrointestinal disorder (<2%)
Fever [6] Local Nausea (3%) [4]
Headache (<5%) [8] Infusion-related reactions [2] Vomiting (<2%) [2]
Insomnia [9] Infusion-site reactions [2]
Leukoencephalopathy [2] Respiratory
Neurotoxicity [11] Other Upper respiratory tract infection (2–3%) [3]
Paresthesias [2] Adverse effects [19] Hematologic
Peripheral neuropathy [22] Allergic reactions [2] Anemia (<2%)
Somnolence (drowsiness) [2] Death [11]
Hiccups [17] Otic
Infection [30] Ear pain (<2%)
Neuromuscular/Skeletal Side effects [3] Tinnitus (<2%)
Arthralgia [5]
Ocular
Ocular edema (<2%)
Back pain [5]
Bone or joint pain [4] DEXCHLOR- Ocular pruritus (<2%)
Muscle spasm [4] Other
Myalgia/Myopathy [6] PHENIRAMINE Adverse effects [2]
Osteonecrosis [15]
Osteoporosis [3]
Gastrointestinal/Hepatic DEXMEDETOMIDINE
Abdominal distension [2]
Abdominal pain [5] DEXIBUPROFEN See: www.drugeruptiondata.com/drug/id/206
Constipation [10]
Diarrhea [17]
Dyspepsia [2] DEXMETHYL-
Gastrointestinal disorder [3]
Hepatotoxicity [4] DEXKETOPROFEN PHENIDATE
Nausea [12]
Pancreatitis [2] See: www.drugeruptiondata.com/drug/id/1232 Trade name: Focalin (Novartis)
Vomiting [7] Indications: Attention deficit disorder
Respiratory Class: CNS stimulant
Cough [3] DEXLANSOPRAZOLE Half-life: 2–4.5 hours
Dyspnea [5]
Pneumonia [14] Trade name: Dexilant (Takeda) interactions with: amitriptyline, clonidine,
Pneumonitis [2] Indications: Erosive esophagitis, heartburn linezolid, MAO inhibitors, pantoprazole
Upper respiratory tract infection [3] associated with gastroesophageal reflux disease Pregnancy category: C
Class: Proton pump inhibitor (PPI) Important contra-indications noted in the
Endocrine/Metabolic prescribing guidelines for: nursing mothers;
Half-life: <2 hours
ALT increased [2] pediatric patients
AST increased [2] Note: Contra-indicated in patients with marked
interactions with: atazanavir, clopidogrel,
Cushing’s syndrome [2] anxiety, tension and agitation, with glaucoma, or
digoxin, emtricitabine/rilpivirine/tenofovir
Dehydration [2] with motor tics or history/diagnosis of Tourette’s
alafenamide, ketoconazole, tacrolimus, warfarin
Hyperglycemia [7] syndrome.
Hypokalemia [5]
prescribing guidelines for: nursing mothers Central Nervous System
Fever (5%)
Renal Headache [4]
Skin
Nephrotoxicity [2]
Acneform eruption (<2%) Gastrointestinal/Hepatic
Hematologic Dermatitis (<2%) Abdominal pain (15%) [2]
Anemia [36] Erythema (<2%)
Febrile neutropenia [7] Endocrine/Metabolic
Hot flashes (<2%) Appetite decreased [2]
Hemoglobin decreased [2] Lesions (<2%)
Hemotoxicity [7] Lymphadenopathy (<2%)
Leukopenia [10] Pruritus (<2%)
Lymphopenia [11] Rash (<2%) DEXRAZOXANE
Myelosuppression [5] Urticaria (<2%)
Neutropenia [49] See: www.drugeruptiondata.com/drug/id/1286
Mucosal
Sepsis [3]
Mucosal inflammation (<2%)
Oral candidiasis (<2%)
Thrombosis [2]
Xerostomia (<2%)
DEXTROAMPHETAMINE See all our books at www.crcpress.com
DEXTRO- DIAZEPAM DICLOFENAC

AMPHETAMINE Trade names: Diastat (Xcel), Valium (Roche) Trade names: Arthrotec (Pfizer), Cataflam
Indications: Anxiety (Novartis), Dicolmax (Galen), Motifene (Daiichi
Trade names: Adderall (Shire), Dexedrine Class: Benzodiazepine, Skeletal muscle relaxant Sankyo), Pennsaid (Mallinckrodt), Solaraze Gel
(Alliant), Mydayis (Shire) Half-life: 2070 hours (Nycomed), Voltaren (Novartis), Voltarol
Indications: Narcolepsy, attention deficit Clinically important, potentially hazardous (Novartis), Zipsor (Depomed)
disorder (ADD) interactions with: alcohol, amprenavir, Indications: Rheumatoid and osteoarthritis,
Class: Amphetamine, CNS stimulant barbiturates, buprenorphine, chlorpheniramine, topical treatment of actinic keratosis,
Half-life: 1012 hours clarithromycin, CNS depressants, cobicistat/ postoperative inflammation in patients who have
Clinically important, potentially hazardous elvitegravir/emtricitabine/tenofovir alafenamide, undergone cataract extraction and for the
interactions with: fluoxetine, fluvoxamine, cobicistat/elvitegravir/emtricitabine/tenofovir temporary relief of pain and photophobia in
MAO inhibitors, paroxetine hydrochloride, disoproxil, efavirenz, esomeprazole, eucalyptus, patients undergoing corneal refractive surgery
phenelzine, sertraline, tranylcypromine fluoroquinolones, imatinib, indinavir, itraconazole, Class: Non-steroidal anti-inflammatory (NSAID)
Pregnancy category: C ivermectin, macrolide antibiotics, MAO inhibitors, Half-life: 12 hours
Important contra-indications noted in the methadone, mianserin, nalbuphine, narcotics, Clinically important, potentially hazardous
prescribing guidelines for: nursing mothers; nelfinavir, nilutamide, olanzapine, omeprazole, interactions with: ACE inhibitors, adrenergic
pediatric patients phenothiazines, propranolol, ritonavir, SSRIs, neurone blockers, aldosterone antagonists,
Warning: ABUSE AND DEPENDENCE voriconazole aliskiren, alpha blockers, angiotensin II receptor
Pregnancy category: D antagonists, anticoagulants, aspirin, baclofen, beta
Skin Important contra-indications noted in the blockers, calcium channel blockers, cardiac
Diaphoresis (<10%) prescribing guidelines for: nursing mothers glycosides, clonidine, clopidogrel, corticosteroids,
coumarins, cyclosporine, dabigatran, deferiprone,
Mucosal
Skin diazoxide, diuretics, enoxaparin, erlotinib,
Xerostomia (<10%)
Dermatitis (<10%) [3] furosemide, heparins, hydralazine, iloprost,
Central Nervous System ketorolac, lithium, methotrexate, methyldopa,
Diaphoresis (>10%)
Insomnia [2] mifamurtide, minoxidil, moxonidine, nitrates,
Exanthems [6]
Neuromuscular/Skeletal Exfoliative dermatitis [2] nitroprusside, penicillamine, pentoxifylline,
Rhabdomyolysis [10] Fixed eruption [2] phenindione, potassium canrenoate, prasugrel,
Pigmentation [2] rifampin, ritonavir, rivaroxaban, SSRIs,
Purpura [4] sulfonylureas, tacrolimus, thiazides, tinzaparin,
venlafaxine, voriconazole, warfarin, zidovudine
DEXTRO- Rash (>10%) [2]
Pregnancy category: D (category B for topical
Mucosal
METHORPHAN Xerostomia (>10%)
use; category C for oral and ophthalmic use;
category D in third trimester.)
Trade names: Robitussin (Wyeth), Vicks Formula Central Nervous System Important contra-indications noted in the
44 (Procter & Gamble) Amnesia [17] prescribing guidelines for: nursing mothers;
Indications: Nonproductive cough Hallucinations [2] pediatric patients
Class: Analgesic, narcotic, NMDA receptor Sedation [3] Note: NSAIDs may cause an increased risk of
antagonist Somnolence (drowsiness) [6] serious cardiovascular and gastrointestinal
Half-life: N/A Vertigo (dizziness) [2] adverse events, which can be fatal. This risk may
Clinically important, potentially hazardous Neuromuscular/Skeletal increase with duration of use.
interactions with: amiodarone, citalopram, Ataxia [2] Contra-indicated in patients who have
iloperidone, linezolid, lorcaserin, memantine, experienced asthma, urticaria, or allergic-type
Endocrine/Metabolic reactions after taking aspirin or other NSAIDs.
moclobemide, phenelzine, rasagiline, safinamide,
Gynecomastia [4] Severe, rarely fatal, anaphylactic-like reactions to
sibutramine, tranylcypromine, valdecoxib
Porphyria [2] NSAIDs have been reported in such patients.
Important contra-indications noted in the Local Arthrotec is diclofenac and misoprostol.
prescribing guidelines for: nursing mothers; Injection-site pain [2] Warning: RISK OF SERIOUS
pediatric patients Injection-site phlebitis (>10%) [2] CARDIOVASCULAR AND
GASTROINTESTINAL EVENTS
Other
Bullous dermatitis [2] Allergic reactions [2] Skin
Fixed eruption [2] Anaphylactoid reactions/Anaphylaxis (<3%)
[16]
Central Nervous System Angioedema (<3%) [2]
Serotonin syndrome [4] DIAZOXIDE Bullous dermatitis (<3%) [2]
Vertigo (dizziness) [2] Dermatitis (<3%) [10]
Gastrointestinal/Hepatic Dermatitis herpetiformis [2]
Diarrhea [2] Eczema (<3%)
Genitourinary Erythema [4]
DICHLORPHENAMIDE Erythema multiforme [6]
Exanthems (<5%) [6]
Other See: www.drugeruptiondata.com/drug/id/1881 Fixed eruption [4]
Adverse effects [2] Hypersensitivity [5]
Nicolau syndrome [16]
DIATRIZOATE Photosensitivity (<3%) [4]
Pruritus (<10%) [6]
See: www.drugeruptiondata.com/drug/id/1112 Purpura (<3%) [2]
Litt’s Drug Eruption & Reaction Manual DIGOXIN
Purpura fulminans [2] mephobarbital, methimazole, metronidazole, Pancreatitis [23]

Rash (>10%) [4] miconazole, penicillins, pentobarbital, Endocrine/Metabolic
Stevens-Johnson syndrome [5] phenobarbital, phenylbutazones, piperacillin, Acidosis [6]
Toxic epidermal necrolysis [4] prednisone, primidone, propylthiouracil, Diabetes mellitus [2]
Urticaria (<3%) [7] quinidine, quinine, rifabutin, rifampin, rifapentine, Gynecomastia [3]
Vasculitis [3] rofecoxib, salicylates, secobarbital,
Xerosis [3] sulfinpyrazone, sulfonamides, testosterone, Renal
zileuton Fanconi syndrome [5]
Hair
Alopecia (<3%) Pregnancy category: D Ocular
Important contra-indications noted in the Retinopathy [3]
Mucosal prescribing guidelines for: nursing mothers
Tongue edema (<3%) Other
Xerostomia (<3%) [2] Death [3]
Skin
Cardiovascular Dermatitis [2]
Cardiotoxicity [2] Exanthems [5]
Myocardial infarction [4] Necrosis [10]
DIETHYLPROPION
Central Nervous System Purplish erythema (feet and toes) [2] See: www.drugeruptiondata.com/drug/id/218
Dysgeusia (taste perversion) (<3%) Purpura [2]
Headache [2] Urticaria [3]
Stroke [3] Hair
Vertigo (dizziness) [4] Alopecia (<10%) [5]
DIETHYLSTILBESTROL
Neuromuscular/Skeletal Hematologic See: www.drugeruptiondata.com/drug/id/219
Rhabdomyolysis [3] Hemorrhage [3]
Abdominal pain [7] DIFLUNISAL
Constipation [3]
Diarrhea [4]
DICYCLOMINE
Dyspepsia [6] See: www.drugeruptiondata.com/drug/id/215
Gastritis [3]
Gastrointestinal bleeding [5]
Gastrointestinal ulceration [4] DIFLUPREDNATE
Hepatotoxicity [10] DIDANOSINE
Nausea [8] See: www.drugeruptiondata.com/drug/id/1306
Vomiting [4] Trade name: Videx (Bristol-Myers Squibb)
Indications: Advanced HIV infection
Renal
Nephrotoxicity [4]
Class: Antiretroviral, Nucleoside analog reverse
transcriptase inhibitor
DIGOXIN
Renal failure [2] Half-life: 1.5 hours Trade name: Lanoxin (Concordia)
Hematologic Clinically important, potentially hazardous Indications: Congestive heart failure, atrial
Agranulocytosis [3] interactions with: acetaminophen, amprenavir, fibrillation
Bleeding [2] ciprofloxacin, corticosteroids, dapsone, darunavir, Class: Antiarrhythmic class IV, Cardiac glycoside,
febuxostat, gemifloxacin, indinavir, itraconazole,
Local Inotrope
ketoconazole, levofloxacin, lomefloxacin, Half-life: 3648 hours
Application-site reactions [3]
lopinavir, moxifloxacin, norfloxacin, ofloxacin, Clinically important, potentially hazardous
Other sulfones, tenofovir disoproxil, tetracycline, interactions with: acarbose, alprazolam,
Adverse effects [11] tipranavir, voriconazole amiodarone, amphotericin B, arbutamine,
Allergic reactions [2] Pregnancy category: B atorvastatin, azithromycin, bendroflumethiazide,
Death [6] Important contra-indications noted in the benzthiazide, bisacodyl, boceprevir, bosutinib,
prescribing guidelines for: the elderly; nursing bumetanide, canagliflozin, captopril, carbimazole,
mothers chlorothiazide, chlorthalidone, cholestyramine,
DICLOXACILLIN Warning: PANCREATITIS, LACTIC ACIDOSIS clarithromycin, cobicistat/elvitegravir/
and HEPATOMEGALY with STEATOSIS emtricitabine/tenofovir alafenamide, cobicistat/
See: www.drugeruptiondata.com/drug/id/213 elvitegravir/emtricitabine/tenofovir disoproxil,
Skin colchicine, conivaptan, cyclopenthiazide,
Erythema multiforme [2] cyclosporine, cyclothiazide, darifenacin, darunavir,
DICUMAROL Lipodystrophy [2] demeclocycline, dexlansoprazole,
Pruritus (9%) dexmedetomidine, doxycycline, dronedarone,
Indications: Atrial fibrillation, pulmonary Rash (9%) erythromycin, eslicarbazepine, esomeprazole,
embolism, venous thrombosis Stevens-Johnson syndrome [3] ethacrynic acid, etravirine, everolimus, ezogabine,
Class: Coumarin Mucosal fingolimod, flibanserin, flunisolide, furosemide,
Half-life: 14 days Xerostomia [4] glycopyrrolate, glycopyrronium,
Clinically important, potentially hazardous hydrochlorothiazide, hydroflumethiazide,
interactions with: allopurinol, amiodarone, Cardiovascular indapamide, indinavir, itraconazole, lapatinib,
amobarbital, anabolic steroids, anti-thyroid Myocardial infarction [2] lenalidomide, liraglutide, lomustine, lopinavir,
agents, aprobarbital, aspirin, barbiturates, Central Nervous System meloxicam, mepenzolate, metformin,
bivalirudin, butabarbital, butalbital, cimetidine, Neurotoxicity [4] methyclothiazide, metolazone, milnacipran,
clofibrate, clopidogrel, cyclosporine, delavirdine, Gastrointestinal/Hepatic minocycline, mirabegron, neratinib, nifedipine,
disulfiram, fenofibrate, fluconazole, gemfibrozil, Hepatotoxicity [2] nilotinib, omeprazole, oxprenolol,
glutethimide, imatinib, itraconazole, Non-cirrhotic portal hypertension [5] oxytetracycline, pantoprazole, paricalcitol,
ketoconazole, levothyroxine, liothyronine, paroxetine hydrochloride, pemetrexed,
DIGOXIN Over 100 updates per week on www.drugeruptiondata.com
phenylbutazone, polythiazide, posaconazole, Gastrointestinal/Hepatic Hypersensitivity [2]

propafenone, propantheline, quinethazone, Abdominal pain [2] Leg ulceration [2]
quinidine, quinine, rabeprazole, rifampin, Constipation [2] Lupus erythematosus [5]
roxithromycin, sitagliptin, sodium picosulfate, Nausea [2] Palmar–plantar desquamation [2]
sorafenib, St John’s wort, sunitinib, telaprevir, Vomiting [2] Peripheral edema (58%)
telithromycin, temozolomide, temsirolimus, Respiratory Photosensitivity [11]
teriparatide, tetracycline, thalidomide, thiazide Respiratory depression [2] Phototoxicity [2]
diuretics, ticagrelor, tipranavir, tolvaptan, Pigmentation [10]
trichlormethiazide, trimethoprim, troglitazone, Genitourinary Pruritus [6]
ulipristal, valbenazine, venetoclax, verapamil, Priapism [2] Psoriasis [3]
zuclopenthixol Renal Purpura [3]
Pregnancy category: C Renal failure [5] Pustules [2]
Important contra-indications noted in the Rash [4]
prescribing guidelines for: the elderly; nursing Stevens-Johnson syndrome [4]
mothers; pediatric patients Thickening [2]
Note: This is the pure form of Digitalis. Contra-
DIHYDROERGO- Toxic epidermal necrolysis [4]
indicated in ventricular fibrillation. TAMINE Toxic erythema [2]
Toxicity [2]
Skin See: www.drugeruptiondata.com/drug/id/222 Urticaria [5]
Exanthems (2%) [2] Vasculitis [6]
Psoriasis [2] Hair
Toxicity [4] DIHYDROTACHYS- Alopecia [2]
Cardiovascular Mucosal
Arrhythmias [7] TEROL Gingival hyperplasia/hypertrophy (21%) [10]
Atrial fibrillation [4] Xerostomia [2]
Bradycardia [3] See: www.drugeruptiondata.com/drug/id/223
Cardiovascular
Tachycardia [2] Atrial fibrillation [2]
Central Nervous System Bradycardia [7]
Anorexia [2] DILTIAZEM Cardiogenic shock [2]
Neuromuscular/Skeletal Flushing (<10%) [6]
Trade names: Cardizem (Biovail), Dilacor XR Hypotension [2]
Asthenia (fatigue) [2] (Watson), Teczem (Sanofi-Aventis), Tiazac
Gastrointestinal/Hepatic (Forest) Central Nervous System
Nausea [4] Indications: Angina, essential hypertension Dysgeusia (taste perversion) [2]
Vomiting [2] Class: Antiarrhythmic class IV, Calcium channel Parkinsonism [3]
blocker, CYP3A4 inhibitor Somnolence (drowsiness) [2]
Endocrine/Metabolic
Gynecomastia [2] Half-life: 58 hours (for extended-release Neuromuscular/Skeletal
capsules) Rhabdomyolysis [4]
Dyschromatopsia (green) [6] Other
interactions with: acebutolol, alfuzosin, Side effects [2]
Hallucinations, visual [2] amiodarone, amitriptyline, amprenavir,
Other aprepitant, atazanavir, atenolol, atorvastatin,
Death [5] avanafil, bisoprolol, bosentan, carbamazepine,
celiprolol, cilostazol, cobicistat/elvitegravir/ DIMENHYDRINATE
emtricitabine/tenofovir alafenamide, cobicistat/
elvitegravir/emtricitabine/tenofovir disoproxil, Trade name: Dramamine (Pfizer)
DIHYDROCODEINE colchicine, copanlisib, corticosteroids, Indications: Motion sickness, dizziness, nausea,
cyclosporine, deflazacort, delavirdine, vomiting
Trade name: DHC-Continus (Napp) Class: Antiemetic, Cholinesterase absorption
dronedarone, dutasteride, efavirenz, epirubicin,
Indications: Severe pain in cancer and other inhibitor
erythromycin, fingolimod, flibanserin, lurasidone,
chronic conditions Half-life: N/A
midostaurin, mifepristone, moricizine,
Class: Analgesic, opioid Clinically important, potentially hazardous
naldemedine, naloxegol, neratinib, nevirapine,
Half-life: 12 hours interactions with: none known
nifedipine, olaparib, oxprenolol, posaconazole,
Clinically important, potentially hazardous Pregnancy category: B
ranolazine, silodosin, simvastatin, sonidegib,
interactions with: CNS depressants, MAO Important contra-indications noted in the
sulpiride, telaprevir, venetoclax
inhibitors, phenothiazines, tranquilizers prescribing guidelines for: nursing mothers
prescribing guidelines for: the elderly; nursing Skin
mothers; pediatric patients Fixed eruption [12]
Note: Teczem is diltiazem and enalapril.
Skin Mucosal
AGEP [2] Xerostomia (<10%)
Skin Central Nervous System
Mucosal AGEP [21]
Xerostomia [2] Somnolence (drowsiness) [5]
Angioedema [3]
Central Nervous System Diaphoresis [2]
Narcosis [2] Edema (<10%) [4]
Seizures [3] Erythema [2] DIMERCAPROL
Somnolence (drowsiness) [2] Erythema multiforme (<31%) [11]
Exanthems [17] See: www.drugeruptiondata.com/drug/id/1056
Exfoliative dermatitis [6]
Litt’s Drug Eruption & Reaction Manual DIPHENOXYLATE
Local
DIMETHYL FUMARATE DINUTUXIMAB Infusion-related reactions (47–60%) [2]
Synonyms: dimethyl (E) butenedioate; BG-12 Trade name: Unituxin (United Therapeutics)
Trade names: Fumaderm (Biogen Idec), Indications: High-risk neuroblastoma in
Tecfidera (Biogen Idec) combination with granulocyte-macrophage DIPHENHYDRAMINE
Indications: Relapsing forms of multiple colony-stimulating factor (GM-CSF), interleukin-2
sclerosis, psoriasis (IL-2), and isotretinoin (13-cis-retinoic acid), in Trade name: Benadryl (Pfizer)
Class: Fumaric acid ester pediatric patients who achieve at least a partial Indications: Allergic rhinitis, urticaria
Half-life: 1 hour response to prior first-line multiagent, Class: Antiemetic, Histamine H1 receptor
Clinically important, potentially hazardous multimodality therapy antagonist, Muscarinic antagonist
interactions with: none known Class: GD2-binding monoclonal antibody, Half-life: 28 hours
Pregnancy category: C Monoclonal antibody Clinically important, potentially hazardous
Important contra-indications noted in the Half-life: 10 days interactions with: alcohol, anticholinergics,
prescribing guidelines for: the elderly; nursing Clinically important, potentially hazardous chloral hydrate, CNS depressants, glutethimide,
mothers; pediatric patients interactions with: none known MAO inhibitors
Note: Fumaderm is mixed dimethyl fumarate and Pregnancy category: N/A (May cause fetal Pregnancy category: B
monoethylfumarate salts. harm) Important contra-indications noted in the
Important contra-indications noted in the prescribing guidelines for: nursing mothers
Skin prescribing guidelines for: the elderly; nursing
Contact dermatitis (from topical contact) mothers Skin
[14] Warning: SERIOUS INFUSION REACTIONS Anaphylactoid reactions/Anaphylaxis [4]
Erythema (5%) [2] AND NEUROTOXICITY Contact dermatitis [2]
Pruritus (8%) [4] Dermatitis [4]
Rash (8%) Skin Eczema [2]
Edema (17%) Fixed eruption [4]
Cardiovascular Photosensitivity [3]
Flushing (40%) [27] Urticaria (25–37%)
Pruritus [2]
Central Nervous System Mucosal Toxic epidermal necrolysis [3]
Leukoencephalopathy [6] Nasal congestion (20%) Toxicity [2]
Neuromuscular/Skeletal Cardiovascular Mucosal
Asthenia (fatigue) [3] Capillary leak syndrome (22–40%) Xerostomia (<10%)
Hypertension (14%)
Gastrointestinal/Hepatic Hypotension (60%) Cardiovascular
Abdominal pain (18%) [11] Tachycardia (19%) QT prolongation [5]
Diarrhea (14%) [10] Torsades de pointes [3]
Dyspepsia (5%) [2] Central Nervous System
Fever (55–72%) Central Nervous System
Nausea [7] Delirium [2]
Vomiting (9%) [3] Pain (61–85%) [2]
Peripheral neuropathy (13%) Sedation [2]
Endocrine/Metabolic Seizures [2]
AST increased (4%) [2] Gastrointestinal/Hepatic Somnolence (drowsiness) [7]
Diarrhea (31–43%)
Genitourinary Nausea (10%) Neuromuscular/Skeletal
Albuminuria (6%) Vomiting (33–46%) Rhabdomyolysis [5]
Urinary tract infection [2] Ocular
Respiratory
Renal Hypoxia (24%) Hallucinations, visual [2]
Proteinuria [2] Wheezing (15%) Other
Hematologic Endocrine/Metabolic Death [4]
Hemotoxicity [2] ALT increased (43–56%)
Lymphopenia (2%) [8] AST increased (16–28%)
Other Creatine phosphokinase increased (15%) DIPHENOXYLATE
Adverse effects (gastrointestinal) [19] Hyperglycemia (18%)
Infection [2] Hypertriglyceridemia (16%) Trade name: Lomotil (Pfizer)
Hypoalbuminemia (29–33%) Indications: Diarrhea
Hypocalcemia (20–27%) Class: Antimotility, Opioid agonist
Hypokalemia (26–43%) Half-life: 2.5 hours
DINOPROSTONE Hypomagnesemia (12%) Clinically important, potentially hazardous
Trade names: Cervidel (Forest), Prepidil (Pfizer) Hyponatremia (36–58%) interactions with: oxybutynin
Indications: Pregnancy termination, uterine Hypophosphatemia (20%) Pregnancy category: C
content evacuation, cervical ripening Weight gain (10%) Important contra-indications noted in the
Class: Prostaglandin Renal prescribing guidelines for: nursing mothers;
Half-life: 2.5–5 minutes Proteinuria (16%) pediatric patients
Clinically important, potentially hazardous Note: Diphenoxylate is almost always prescribed
Hematologic with atropine sulfate.
interactions with: none known Anemia (42–51%)
Pregnancy category: C Hemorrhage (17%)
Note: Dinoprostone is the naturally occurring Lymphopenia (54–62%) Mucosal
form of Prostaglandin E2 (PGE2). Neutropenia (25–39%) Xerostomia (3%)
Sepsis (18%)
Thrombocytopenia (61–66%)
DIPHTHERIA ANTITOXIN See all our books at www.crcpress.com
Pregnancy category: C omeprazole, oxtriphylline, phenytoin,

DIPHTHERIA Important contra-indications noted in the thalidomide, tipranavir, warfarin
prescribing guidelines for: nursing mothers; Pregnancy category: C
ANTITOXIN pediatric patients Important contra-indications noted in the
Skin pediatric patients
Dermatitis (<3%)
Edema (<3%) Skin
DIPYRIDAMOLE Exanthems (<5%) Acneform eruption [3]
Lupus erythematosus [3] Bullous dermatitis [2]
Trade names: Aggrenox (Boehringer Ingelheim),
Pruritus (<3%) Dermatitis [17]
Persantine (Boehringer Ingelheim)
Rash (generalized) (<3%) Eczema [2]
Indications: Thromboembolic complications
Mucosal Exanthems [2]
following cardiac valve replacement
Oral lesions (40%) Fixed eruption [2]
Class: Adenosine reuptake inhibitor, Antiplatelet
Xerostomia (32%) [2] Rash (<10%)
Recall reaction (nickel) [4]
Clinically important, potentially hazardous Cardiovascular Urticaria [3]
interactions with: adenosine, ceftobiprole, Chest pain (<3%)
clopidogrel, enoxaparin, fondaparinux, Hypotension (<3%) Cardiovascular
regadenoson, reteplase, riociguat, tinzaparin QT prolongation [8] Flushing (with alcohol) [5]
Pregnancy category: B Torsades de pointes [13] Hypertension [2]
Important contra-indications noted in the Hypotension [2]
Central Nervous System Polyarteritis nodosa [2]
Anorexia (<3%) Tachycardia [2]
pediatric patients
Headache (3–9%)
Note: Aggrenox is dipyridamole and aspirin. Central Nervous System
Nervousness (<3%)
Syncope (<3%) Dysgeusia (taste perversion) (metallic or
Skin Vertigo (dizziness) (3–9%) garlic aftertaste) (<10%)
Rash (2%) Neurotoxicity [6]
Neuromuscular/Skeletal Psychosis [5]
Asthenia (fatigue) (3–9%) Seizures [2]
Cardiovascular
Gastrointestinal/Hepatic Somnolence (drowsiness) [2]
Flushing (3%)
Abdominal pain (3–9%) Vertigo (dizziness) [2]
Central Nervous System Constipation (11%) [2] Neuromuscular/Skeletal
Headache [3] Diarrhea (<3%) Asthenia (fatigue) [2]
Other Nausea (3–9%)
Vomiting (<3%) Ocular
Adverse effects [3]
Optic neuropathy [2]
Respiratory
Dyspnea (<3%) Other
Adverse effects [2]
DIRITHROMYCIN Endocrine/Metabolic
Hypocalcemia [3]
See: www.drugeruptiondata.com/drug/id/230 Hypoglycemia [4]
Hypokalemia (<3%) DOBUTAMINE
Weight gain (<3%)
DISOPYRAMIDE Genitourinary
Impotence (<3%)
Trade name: Norpace (Pfizer) Urinary hesitancy (14%)
Indications: Ventricular arrhythmias Urinary retention (3–9%) DOCETAXEL
Class: Antiarrhythmic, Antiarrhythmic class Ia,
Muscarinic antagonist
Ocular Trade name: Taxotere (Sanofi-Aventis)
Half-life: 410 hours Vision blurred (3–9%) Indications: Metastatic breast cancer, non-small
Clinically important, potentially hazardous Xerophthalmia (3–9%) cell lung cancer, with prednisone in hormone
interactions with: acebutolol, amiodarone, refractory prostate cancer, with cisplatin and
amisulpride, amitriptyline, arsenic, artemether/ fluorouracil for gastric adenocarcinoma and
lumefantrine, astemizole, atenolol, bisoprolol, DISTIGMINE squamous cell carcinoma of the head and neck
celiprolol, ciprofloxacin, clarithromycin, Class: Antineoplastic, Taxane
cobicistat/elvitegravir/emtricitabine/tenofovir See: www.drugeruptiondata.com/drug/id/1348 Half-life: 1118 hours
alafenamide, cobicistat/elvitegravir/emtricitabine/ Clinically important, potentially hazardous
tenofovir disoproxil, darifenacin, degarelix, interactions with: alcohol, aldesleukin,
anthracyclines, antifungals, aprepitant, BCG
dronedarone, droperidol, enoxacin,
erythromycin, gatifloxacin, gliclazide,
DISULFIRAM vaccine, conivaptan, cyclosporine, CYP3A4
glycopyrrolate, glycopyrronium, insulin aspart, Trade name: Antabuse (Odyssey) inhibitors or inducers, dasatinib, deferasirox,
insulin degludec, insulin glargine, insulin glulisine, Indications: Alcoholism denosumab, echinacea, erythromycin,
itraconazole, ketoconazole, levomepromazine, Class: Antialcoholism, Antioxidant itraconazole, ketoconazole, lapatinib,
lomefloxacin, lurasidone, metformin, Half-life: N/A leflunomide, natalizumab, P-glycoprotein
moxifloxacin, nevirapine, nilotinib, norfloxacin, Clinically important, potentially hazardous inhibitors or inducers, pimecrolimus, prednisone,
ofloxacin, oxprenolol, oxybutynin, pimavanserin, interactions with: acenocoumarol, alcohol, ritonavir, sipuleucel-T, sorafenib, St John’s wort,
quinine, quinolones, ribociclib, rifapentine, amitriptyline, anisindione, anticoagulants, tacrolimus, thalidomide, trastuzumab, vaccines,
roxithromycin, sildenafil, sotalol, sparfloxacin, benznidazole, clobazam, cyclosporine, dicumarol, voriconazole
sulpiride, tadalafil, telithromycin, tiotropium, dronabinol, ethanolamine, ethotoin, fosphenytoin,
trospium, vandetanib, vardenafil, zuclopenthixol lopinavir, mephenytoin, metronidazole,
Litt’s Drug Eruption & Reaction Manual DOMPERIDONE
Pregnancy category: D Pain [5]

Important contra-indications noted in the Paresthesias (4%) [2] DOCUSATE
prescribing guidelines for: the elderly; nursing Peripheral neuropathy [10]
mothers; pediatric patients Vertigo (dizziness) [2] See: www.drugeruptiondata.com/drug/id/236
Note: Contra-indicated in patients with Neuromuscular/Skeletal
hypersensitivity to docetaxel or polysorbate 80, Arthralgia (3–9%) [3]
or with neutrophil counts of <1500 cells/mm3. Asthenia (fatigue) (53–66%) [60] DOFETILIDE
Warning: TOXIC DEATHS, HEPATOTOXICITY, Bone or joint pain [2]
NEUTROPENIA, HYPERSENSITIVITY Myalgia/Myopathy (3–23%) [10] See: www.drugeruptiondata.com/drug/id/237
REACTIONS, and FLUID RETENTION
Abdominal pain [4]
Skin Constipation [3] DOLASETRON
AGEP [2] Diarrhea (23–43%) [48]
Anaphylactoid reactions/Anaphylaxis [3] Dysphagia [2] See: www.drugeruptiondata.com/drug/id/238
Edema (34%) [24] Hepatotoxicity [2]
Erythema [4] Nausea (34–42%) [27]
Exanthems [3] Vomiting (22–23%) [20] DOLUTEGRAVIR
Facial erythema [2]
Flagellate erythema/pigmentation [2] Respiratory
Acute respiratory distress syndrome [2] Trade names: Tivicay (ViiV), Triumeq (ViiV)
Hand–foot syndrome [42] Indications: HIV-1 infection
Hypersensitivity (6%) [15] Cough [2]
Dyspnea [5] Class: Antiretroviral, Integrase strand transfer
Peripheral edema [9] inhibitor
Photosensitivity [6] Pleural effusion [2]
Pneumonia [3] Half-life: ~14 hours
Pigmentation [2] Clinically important, potentially hazardous
Psoriasis [3] Pneumonitis [10]
Pulmonary embolism [2] interactions with: dofetilide
Radiation recall dermatitis [18] Pregnancy category: B
Rash [12] Pulmonary toxicity (41%) [4]
Respiratory failure [2] Important contra-indications noted in the
Recall reaction [2] prescribing guidelines for: nursing mothers;
Scleroderma [9] Upper respiratory tract infection [3]
pediatric patients
Thrombocytopenic purpura [2] Endocrine/Metabolic Note: Triumeq is abacavir, dolutegravir and
Toxicity (20–48%) [10] ALP increased (4–7%) lamivudine.
Xerosis [2] ALT increased [5]
Hair Amenorrhea [4]
Appetite decreased [3] Skin
Alopecia (56–76%) [30] Hypersensitivity [5]
AST increased [4]
Nails Dehydration [2] Pruritus (<2%)
Beau’s lines (transverse nail bands) [2] Hyperglycemia [3] Rash [3]
Discoloration [2] Hyponatremia [4] Central Nervous System
Melanonychia [2] Hypophosphatemia [2] Abnormal dreams [2]
Nail changes [17] Headache (<2%) [17]
Nail disorder (11–41%) [2] Hematologic
Anemia (65–94%) [24] Insomnia (<3%) [4]
Nail loss [3]
Nail pigmentation [6] Febrile neutropenia (6%) [49] Neuromuscular/Skeletal
Onycholysis [15] Hemolytic uremic syndrome [3] Asthenia (fatigue) (<2%) [3]
Onychopathy [2] Hemotoxicity [3] Myalgia/Myopathy (<2%)
Paronychia [4] Leukocytopenia [4] Gastrointestinal/Hepatic
Pyogenic granuloma [2] Leukopenia (84–99%) [26] Abdominal pain (<2%)
Subungual abscess [2] Lymphopenia [4] Diarrhea [16]
Subungual hemorrhage [2] Myelosuppression [2] Flatulence (<2%)
Transverse superficial loss of nail plate [2] Neutropenia (84–99%) [86] Hepatitis (<2%)
Thrombocytopenia (8–14%) [12] Nausea [14]
Mucosal
Aphthous stomatitis [2] Ocular Vomiting (<2%)
Mucositis [15] Epiphora [8] Respiratory
Oral mucositis [5] Local Nasopharyngitis [3]
Stomatitis (19–53%) [19] Injection-site erythema [2] Upper respiratory tract infection [2]
Cardiovascular Injection-site extravasation [3] Endocrine/Metabolic
Capillary leak syndrome [2] Injection-site pigmentation [3] ALT increased (<2%) [3]
Cardiotoxicity [2] Injection-site reactions [2] AST increased (<3%)
Flushing [2] Other Creatine phosphokinase increased (<4%)
Hypertension [10] Adverse effects [4] Hyperglycemia (5–7%)
Hypotension (3%) Allergic reactions [2] Renal
Thromboembolism [2] Death [17] Nephrotoxicity (<2%)
Central Nervous System Infection (<34%) [9]
Other
Anorexia [11]
Adverse effects [4]
Dysesthesia (4%)
Dysgeusia (taste perversion) (6%) [7] DOCOSANOL
Fever (31–35%) [6]
Headache [2] See: www.drugeruptiondata.com/drug/id/957 DOMPERIDONE
Mood changes [2]
Neurotoxicity [20] See: www.drugeruptiondata.com/drug/id/843
DONEPEZIL Over 100 updates per week on www.drugeruptiondata.com
Nausea (6–11%) [14] Pregnancy category: C

DONEPEZIL Vomiting (5–8%) [8] Important contra-indications noted in the
Endocrine/Metabolic prescribing guidelines for: nursing mothers
Trade names: Aricept (Eisai), Aricept Evess Note: Dorzolamide is a sulfonamide and can be
(Eisai) Appetite decreased [4]
Creatine phosphokinase increased (3%) absorbed systemically. Sulfonamides can produce
Indications: Mild, moderate and severe severe, possibly fatal, reactions such as toxic
dementia of the Alzheimer’s type Dehydration (2%)
Hyperlipidemia (2%) epidermal necrolysis and Stevens-Johnson
Class: Acetylcholinesterase inhibitor, syndrome.
Cholinesterase inhibitor, Parasympathomimetic Weight loss (3%)
Cosopt is dorzolamide and timolol.
Half-life: 5070 hours Genitourinary
Clinically important, potentially hazardous Urinary frequency (2%) [2]
interactions with: anticholinergics, cholinergic Urinary incontinence (2%) Skin
agonists, galantamine, non-depolarising muscle Urinary tract infection [3] Contact dermatitis [4]
relaxants, ramelteon, succinylcholine Hematologic Central Nervous System
Pregnancy category: C Hemorrhage (2%) Dysgeusia (taste perversion) (25%) [8]
Important contra-indications noted in the Ocular
prescribing guidelines for: nursing mothers; Other
Adverse effects [9] Ocular burning (33%) [5]
pediatric patients Ocular pain [2]
Note: Contra-indicated in patients with known Infection (11%)
Ocular pruritus [4]
hypersensitivity to donepezil hydrochloride or to Ocular stinging [10]
piperidine derivatives. Vision blurred [3]
DOPAMINE Other
Diaphoresis [2] Trade name: Intropin (Hospira)
Ecchymoses (4–5%) Indications: Hemodynamic imbalances present
Eczema (3%) in shock
Purpura (<10%) Class: Adrenergic alpha-receptor agonist, DOXACURIUM
Catecholamine, Inotropic sympathomimetic
Cardiovascular Half-life: 2 minutes See: www.drugeruptiondata.com/drug/id/242
Atrioventricular block [2] Clinically important, potentially hazardous
Bradycardia [7] interactions with: ethotoin, fosphenytoin,
Chest pain (2%)
Hypertension [2]
furazolidone, lurasidone, MAO inhibitors,
mephenytoin, phenelzine, phenytoin, quetiapine,
DOXAPRAM
Hypotension (3%) tranylcypromine
QT prolongation [4] See: www.drugeruptiondata.com/drug/id/243
Torsades de pointes [2] Important contra-indications noted in the
Central Nervous System prescribing guidelines for: nursing mothers;
Abnormal dreams (3%) [2] pediatric patients DOXAZOSIN
Agitation [2]
Anorexia (4–8%) [5] Trade name: Cardura (Pfizer)
Cardiovascular Indications: Hypertension
Confusion (2%) [3] QT prolongation [2]
Delirium [2] Class: Adrenergic alpha-receptor antagonist
Depression (2–3%) [3] Local Half-life: 1922 hours
Emotional lability (2%) Injection-site extravasation [2] Clinically important, potentially hazardous
Fever (3%) Injection-site necrosis [3] interactions with: tadalafil, vardenafil,
Gait instability [2] zuclopenthixol
Hallucinations (3%) Pregnancy category: C
Headache (4–10%) [6] DOPEXAMINE Important contra-indications noted in the
Hostility (3%)
Insomnia (5–9%) [4] See: www.drugeruptiondata.com/drug/id/1331 mothers; pediatric patients
Mania [2]
Nervousness (3%) Skin
Neuroleptic malignant syndrome [2] DORIPENEM Edema (4%)
Pain (3–9%) Exanthems (2%)
Parkinsonism [2] See: www.drugeruptiondata.com/drug/id/1254 Mucosal
Somnolence (drowsiness) (2%) [2] Xerostomia (2%) [2]
Syncope (2%) [5]
Tremor [3] Cardiovascular
Vertigo (dizziness) (2–8%) [6] DORNASE ALFA Hypotension [3]
Orthostatic hypotension [2]
Neuromuscular/Skeletal See: www.drugeruptiondata.com/drug/id/1048 Postural hypotension [2]
Arthralgia (2%)
Asthenia (fatigue) (5%) [3] Central Nervous System
Back pain (3%) Headache [2]
Dystonia [2] DORZOLAMIDE Vertigo (dizziness) [9]
Muscle spasm [2] Neuromuscular/Skeletal
Myoclonus [2] Trade names: Cosopt (Merck), Trusopt (Banyu) Asthenia (fatigue) [4]
Indications: Glaucoma, ocular hypertension
Gastrointestinal/Hepatic Class: Carbonic anhydrase inhibitor, Diuretic Gastrointestinal/Hepatic
Constipation [3] Half-life: ~4 months Abdominal pain [2]
Diarrhea (10%) [11] Clinically important, potentially hazardous Genitourinary
Hepatotoxicity [3] interactions with: none known Erectile dysfunction [3]
Litt’s Drug Eruption & Reaction Manual DOXYCYCLINE
Ocular Skin Amenorrhea [2]

Floppy iris syndrome [3] Anaphylactoid reactions/Anaphylaxis [2] Renal
Angioedema [5] Nephrotoxicity [2]
Erythema [2]
Hematologic
DOXEPIN Exanthems [4]
Exfoliative dermatitis [2] Anemia [12]
Hand–foot syndrome [60] Febrile neutropenia [15]
Trade names: Adapin (LGM Pharma), Silenor Hemorrhage [2]
(Somaxon), Sinquan (Pfizer) Hypersensitivity [2]
Intertrigo [3] Hemotoxicity [2]
Indications: Mental depression, anxiety, insomnia Leukopenia [3]
Class: Antidepressant, tricyclic, Muscarinic Lupus erythematosus [3]
Necrosis (local) [5] Neutropenia [31]
antagonist Thrombocytopenia [18]
Half-life: 68 hours Palmar–plantar erythema (painful) [4]
Clinically important, potentially hazardous Pigmentation [15] Local
interactions with: alcohol, amprenavir, Pruritus [2] Injection-site erythema [7]
arbutamine, cholestyramine, clonidine, CNS Purpura [2] Injection-site extravasation (>10%) [12]
depressants, epinephrine, formoterol, Radiation recall dermatitis [8] Injection-site necrosis (>10%) [5]
guanethidine, isocarboxazid, linezolid, MAO Rash [6] Injection-site reactions [2]
inhibitors, phenelzine, QT prolonging agents, Toxicity [12] Injection-site ulceration (>10%) [4]
quinolones, ramelteon, selegiline, sparfloxacin, Urticaria [10] Other
sympathomimetics, tranylcypromine Hair Adverse effects [5]
Pregnancy category: C (pregnancy category is Alopecia (>10%) [39] Allergic reactions [3]
B for topical use) Nails Death [10]
Important contra-indications noted in the Beau’s lines [2] Infection [4]
prescribing guidelines for: nursing mothers Melanonychia [2]
Warning: SUICIDALITY AND Nail changes [2]
ANTIDEPRESSANT DRUGS Nail pigmentation [16] DOXYCYCLINE
Onycholysis [5]
Skin Mucosal Trade names: Adoxa (Bioglan), Doryx (Warner
Dermatitis (from topical) [9] Aphthous stomatitis [2] Chilcott), Oracea (Galderma), Vibra-Tabs (Pfizer),
Diaphoresis (<10%) Mucositis [16] Vibramycin-D (Pfizer)
Pseudolymphoma [2] Oral lesions [7] Indications: Various infections caused by
Mucosal Stomatitis (>10%) [19] susceptible organisms
Xerostomia (>10%) [6] Tongue pigmentation [3] Class: Antibiotic, tetracycline
Cardiovascular Cardiovascular Clinically important, potentially hazardous
QT prolongation [2] Atrial fibrillation [2] interactions with: acitretin, amoxicillin,
Central Nervous System Cardiomyopathy [5] ampicillin, antacids, bacampicillin, barbiturates,
Dysgeusia (taste perversion) (>10%) Cardiotoxicity [18] BCG vaccine, bismuth, calcium salts,
Headache [4] Chest pain [2] carbamazepine, carbenicillin, cloxacillin,
Somnolence (drowsiness) [7] Congestive heart failure [5] corticosteroids, coumarins, cyclosporine, dairy
Flushing (<10%) [2] products, digoxin, ergotamine, kaolin,
Myocardial toxicity [4] methotrexate, methoxyflurane, methysergide,
DOXERCALCIFEROL Central Nervous System mezlocillin, nafcillin, oral contraceptives, oral iron,
Anorexia [3] oral typhoid vaccine, oxacillin, penicillins,
See: www.drugeruptiondata.com/drug/id/246 Dysgeusia (taste perversion) [2] phenindione, phenytoin, piperacillin, primidone,
Fever [5] quinapril, retinoids, rifampin, St John’s wort,
Headache [3] strontium ranelate, sucralfate, sulfonylureas,
Leukoencephalopathy [4] ticarcillin, tripotassium dicitratobismuthate, zinc
DOXORUBICIN Neurotoxicity [4] Pregnancy category: D
Pain [2] Important contra-indications noted in the
Synonym: hydroxydaunomycin Peripheral neuropathy [5] prescribing guidelines for: nursing mothers;
Trade names: Adriamycin (Bedford), Doxil pediatric patients
(Tibotec), Rubex (Mead Johnson) Neuromuscular/Skeletal
Indications: Carcinomas, leukemias, sarcomas Asthenia (fatigue) [17]
Class: Antibiotic, anthracycline Bone or joint pain [2] Skin
Half-life: 20–48 hours Myalgia/Myopathy [2] AGEP [2]
Clinically important, potentially hazardous Gastrointestinal/Hepatic Angioedema [2]
interactions with: aldesleukin, cabazitaxel, Constipation [3] Candidiasis [3]
CYP2D6 inhibitors or inducers, CYP3A4 Diarrhea [5] Erythema multiforme [4]
inhibitors or inducers, gadobenate, P-glycoprotein Gastrointestinal perforation [2] Exanthems [2]
inhibitors or inducers, paclitaxel, sorafenib, Hepatotoxicity [6] Fixed eruption [9]
stavudine, trastuzumab, zidovudine Nausea [11] Hypersensitivity [2]
Pregnancy category: D Pancreatitis [2] Photosensitivity [20]
Important contra-indications noted in the Vomiting [10] Phototoxicity [9]
prescribing guidelines for: nursing mothers Pigmentation [5]
Respiratory Pruritus [3]
Warning: CARDIOMYOPATHY, SECONDARY Dyspnea [3]
MALIGNANCIES, EXTRAVASATION AND Rash [5]
Pneumonia [3] Stevens-Johnson syndrome [6]
TISSUE NECROSIS, and SEVERE Pneumonitis [2]
MYELOSUPPRESSION Sweet’s syndrome [2]
Endocrine/Metabolic Toxic epidermal necrolysis [2]
ALT increased [3] Urticaria [6]
DOXYCYCLINE See all our books at www.crcpress.com
Nails Respiratory
Photo-onycholysis [13] DRONEDARONE Pulmonary toxicity [9]
Mucosal Trade name: Multaq (Sanofi-Aventis) Endocrine/Metabolic
Black tongue [2] Indications: Atrial fibrillation and atrial flutter Serum creatinine increased (51%) [6]
Mucosal candidiasis [2] Class: Antiarrhythmic, Antiarrhythmic class III Renal
Central Nervous System Half-life: 13–19 hours Nephrotoxicity [2]
Anosmia [2] Clinically important, potentially hazardous Renal failure [2]
Fever [2] interactions with: amiodarone, amitriptyline, Other
Headache [4] amoxapine, antiarrhythmics, antipsychotics Adverse effects [2]
Intracranial pressure increased [2] prolonging QT interval, arsenic, atorvastatin, beta Death [2]
Paresthesias [4] blockers, bupivacaine, calcium channel blockers, Side effects [2]
Vertigo (dizziness) [3] carbamazepine, citalopram, clarithromycin,
Neuromuscular/Skeletal conivaptan, coumarins, cyclosporine, CYP3A
inducers, dabigatran, darunavir, dasabuvir/
ombitasvir/paritaprevir/ritonavir, dasatinib, DROPERIDOL
Gastrointestinal/Hepatic degarelix, delavirdine, digoxin, diltiazem,
Abdominal pain [3] disopyramide, dolasetron, efavirenz, Trade names: Inapsine (Akorn), Xomolix
Diarrhea [3] erythromycin, fingolimod, grapefruit juice, (ProStrakan)
Esophagitis [3] indinavir, itraconazole, ketoconazole, lapatinib, Indications: Tranquilizer and antiemetic in
Hepatotoxicity [2] levobupivacaine, levofloxacin, levomepromazine, surgical procedures
Nausea [5] metoprolol, moxifloxacin, nefazodone, neratinib, Class: Antiemetic, Antipsychotic, Butyrophenone
Pancreatitis [3] nifedipine, ombitasvir/paritaprevir/ritonavir, Half-life: 2.3 hours
Ulcerative esophagitis [2] oxcarbazepine, pazopanib, phenindione, Clinically important, potentially hazardous
Vomiting [3] phenobarbital, phenothiazines, phenytoin, interactions with: amiodarone, amisulpride,
Endocrine/Metabolic posaconazole, prilocaine, propranolol, rifampin, amitriptyline, arsenic, atomoxetine, azithromycin,
Hypoglycemia [2] rifapentine, ritonavir, ropivacaine, rosuvastatin, chloroquine, CNS depressants, cyclobenzaprine,
saquinavir, simvastatin, sirolimus, sotalol, St John’s disopyramide, duloxetine, eszopiclone,
Genitourinary fluoxetine, fluvoxamine, hydromorphone,
wort, statins, tacrolimus, telavancin,
Vaginitis [2] hydroxychloroquine, levomepromazine,
telithromycin, tricyclic antidepressants,
Other venetoclax, verapamil, voriconazole, vorinostat, lurasidone, macrolides, metaxalone, milnacipran,
Adverse effects [6] warfarin, ziprasidone moxifloxacin, paliperidone, pentamidine,
Allergic reactions [3] Pregnancy category: X pimozide, QT prolonging agents, quinine,
Tooth pigmentation (>10%) [5] Important contra-indications noted in the ramelteon, sertraline, sotalol, sulpiride,
prescribing guidelines for: nursing mothers; tamoxifen, tapentadol, thiopental, tiagabine,
pediatric patients tricyclic antidepressants
DRONABINOL Warning: INCREASED RISK OF DEATH,
STROKE AND HEART FAILURE IN PATIENTS
Synonyms: tetrahydrocannabinol; THC WITH DECOMPENSATED HEART FAILURE OR prescribing guidelines for: nursing mothers;
Trade names: Marinol (AbbVie), Syndros (Insys) PERMANENT ATRIAL FIBRILLATION pediatric patients
Indications: Chemotherapy-induced nausea, Note: Contra-indicated in patients with known
anorexia associated with weight loss in patients or suspected QT prolongation.
Skin This product is not available in the European
with AIDS Anaphylactoid reactions/Anaphylaxis [2]
Class: Antiemetic, Cannabinoid market.
Dermatitis (5%) Warning: QT PROLONGATION AND
Half-life: 1924 hours Eczema (5%)
Clinically important, potentially hazardous TORSADE DE POINTES
Erythema (5%)
interactions with: disulfiram, metronidazole Pruritus (5%)
Pregnancy category: C Rash (5%) [8] Skin
Important contra-indications noted in the Anaphylactoid reactions/Anaphylaxis [3]
Cardiovascular Angioedema [2]
Arrhythmias [3]
Bradycardia (3%) [8] Cardiovascular
Cardiac failure (new or worsening) [9] Arrhythmias [2]
Mucosal Cardiotoxicity [3] QT prolongation [13]
Xerostomia (<10%) Congestive heart failure [2] Torsades de pointes [6]
Central Nervous System QT prolongation (28%) [10] Central Nervous System
Euphoria (<10%) Torsades de pointes [3] Akathisia [5]
Paranoia (<10%) Central Nervous System Extrapyramidal symptoms [2]
Somnolence (drowsiness) (<10%) Vertigo (dizziness) [2] Neuroleptic malignant syndrome [2]
Vertigo (dizziness) (<10%) [5] Restlessness [2]
Neuromuscular/Skeletal Sedation [2]
Gastrointestinal/Hepatic Asthenia (fatigue) (7%) [3]
Abdominal pain (<10%) Neuromuscular/Skeletal
Nausea (<10%) [2] Gastrointestinal/Hepatic Dystonia [6]
Vomiting (<10%) Abdominal pain (4%) [2]
Diarrhea (9%) [14] Other
Other Dyspepsia (2%) Death [3]
Adverse effects [4] Gastrointestinal disorder [4]
Hepatic failure [5]
Hepatotoxicity [9] DROTRECOGIN ALFA
Nausea (5%) [12]
Vomiting (2%) [6] See: www.drugeruptiondata.com/drug/id/918
Litt’s Drug Eruption & Reaction Manual DUPILUMAB
Endocrine/Metabolic Colitis [2]

DROXIDOPA Appetite decreased (5–9%) [2] Constipation (10%) [8]
Local Diarrhea (9%) [6]
Synonym: L-DOPS Hepatotoxicity (rare) [4]
Trade name: Northera (Chelsea Therapeutics) Injection-site reactions [5]
Nausea (24%) [24]
Indications: Neurogenic orthostatic hypotension Other Vomiting (>2%) [3]
Class: Amino acid analog (synthetic) Adverse effects (gastrointestinal) [4]
Half-life: 2.5 hours Respiratory
Clinically important, potentially hazardous Cough (>2%)
Influenza (3%)
DULOXETINE Nasopharyngitis (5%)
Important contra-indications noted in the Upper respiratory tract infection (4%)
Trade names: Cymbalta (Lilly), Yentreve (Lilly)
prescribing guidelines for: nursing mothers; Indications: Depression Endocrine/Metabolic
pediatric patients Class: Antidepressant, Noradrenaline reuptake ALT increased [2]
Warning: SUPINE HYPERTENSION inhibitor, Serotonin reuptake inhibitor Appetite decreased (8–9%) [2]
Half-life: 817 hours Hyponatremia [2]
Cardiovascular Clinically important, potentially hazardous Libido decreased (4%)
Hypertension (2–7%) interactions with: 5HT1 agonists, alcohol, SIADH [6]
amitriptyline, artemether/lumefantrine, aspirin, Weight loss (>2%)
Gait instability (15%) [2] atomoxetine, cimetidine, ciprofloxacin, Genitourinary
Headache (6–15%) [3] citalopram, clomipramine, CYP1A2 inducers, Ejaculatory dysfunction (2–5%)
Syncope (13%) CYP2D6 inhibitors and substrates, darunavir, Sexual dysfunction [6]
Vertigo (dizziness) (4–10%) [2] droperidol, enoxacin, fesoterodine, fluoxetine, Ocular
fluvoxamine, iobenguane, levomepromazine, Vision blurred (>2%)
Gastrointestinal/Hepatic MAO inhibitors, meperidine, moclobemide,
Nausea (2–9%) naratriptan, nebivolol, NSAIDs, paroxetine Other
Genitourinary hydrochloride, PEG-interferon, quinidine, Adverse effects [11]
Urinary tract infection (15%) [2] sibutramine, SSRIs, St John’s wort, tamoxifen, Bruxism [3]
teriflunomide, thioridazine, tramadol, tricyclic Death [2]
antidepressants, tryptophan, venlafaxine, warfarin
DULAGLUTIDE Pregnancy category: C
Important contra-indications noted in the DUPILUMAB *
Trade name: Trulicity (Lilly) prescribing guidelines for: nursing mothers;
Indications: To improve glycemic control in pediatric patients Trade name: Dupixent (Regeneron)
adults with Type II diabetes mellitus Warning: SUICIDAL THOUGHTS AND Indications: Moderate-to-severe atopic
Class: Glucagon-like peptide-1 (GLP-1) receptor BEHAVIORS dermatitis
agonist Class: Interleukin-4 receptor alpha antagonist,
Half-life: 5 days Skin Monoclonal antibody
Clinically important, potentially hazardous Diaphoresis (6%) [2] Half-life: N/A
interactions with: none known Hot flashes (>2%) Clinically important, potentially hazardous
Pregnancy category: C Hyperhidrosis (7%) [8] interactions with: none known
Important contra-indications noted in the Pregnancy category: N/A (Insufficient evidence
Mucosal to inform drug-associated risk)
prescribing guidelines for: nursing mothers; Oropharyngeal pain (>2%)
pediatric patients Important contra-indications noted in the
Xerostomia (13%) [23] prescribing guidelines for: pediatric patients
Note: Contra-indicated in patients with a
personal or family history of medullary thyroid Cardiovascular
carcinoma or in patients with multiple endocrine Flushing (3%) Skin
neoplasia syndrome Type 2. Palpitation (>2%) Herpes simplex (2%)
Warning: RISK OF THYROID C-CELL TUMORS Central Nervous System Mucosal
Agitation (5%) Oral candidiasis (4%)
Cardiovascular Anxiety (3%)
Headache (14%) [11] Central Nervous System
Atrioventricular block (2%) Headache [2]
Tachycardia (3–6%) Insomnia (10%) [13]
Paresthesias (>2%) Respiratory
Central Nervous System Restless legs syndrome [2] Nasopharyngitis [3]
Headache [3] Serotonin syndrome [4] Ocular
Neuromuscular/Skeletal Somnolence (drowsiness) (10%) [15] Conjunctivitis (10%) [3]
Asthenia (fatigue) (4–6%) Suicidal ideation [4]
Tardive dyskinesia [3] Local
Gastrointestinal/Hepatic Injection-site reactions (10%) [3]
Abdominal pain (7–9%) Tremor (3%)
Constipation [4] Vertigo (dizziness) (10%) [15]
Diarrhea [22] Yawning (>2%) [2]
Dyspepsia (4–6%) [3] Neuromuscular/Skeletal
Nausea (12–21%) [23] Arthralgia (>2%)
Pancreatitis [2] Asthenia (fatigue) (10%) [14]
Vomiting (6–13%) [16] Back pain (>2%)
Respiratory Bone or joint pain (4%)
Nasopharyngitis [6] Muscle spasm (3%)
Abdominal pain (>2%)
DURVALUMAB Over 100 updates per week on www.drugeruptiondata.com
Constipation (21%)
DURVALUMAB * Diarrhea (13%) [3] DUTASTERIDE
Nausea (16%)
Trade name: Imfinzi (AstraZeneca) Trade names: Avodart (GSK), Jalyn (GSK)
Indications: Locally advanced or metastatic Respiratory Indications: Benign prostatic hyperplasia, male
urothelial carcinoma in patients having disease Cough (10%) pattern baldness (anecdotal)
progression following platinum-containing Dyspnea (13%) Class: 5-alpha reductase inhibitor, Androgen
chemotherapy Pneumonitis (2%) antagonist
Class: Monoclonal antibody, Programmed death- Endocrine/Metabolic Half-life: 35 weeks
ligand (PD-L1) inhibitor ALP increased (4%) Clinically important, potentially hazardous
Half-life: 17 days Appetite decreased (19%) interactions with: cimetidine, ciprofloxacin,
Clinically important, potentially hazardous AST increased (2%) conivaptan, darunavir, delavirdine, diltiazem,
interactions with: none known Hypercalcemia (3%) indinavir, ketoconazole, ritonavir, telithromycin,
Pregnancy category: N/A (Can cause fetal Hyperglycemia (3%) troleandomycin, verapamil, voriconazole
harm) Hypermagnesemia (4%) Pregnancy category: X
Important contra-indications noted in the Hyperthyroidism (5–6%) Important contra-indications noted in the
prescribing guidelines for: the elderly; nursing Hyponatremia (12%) prescribing guidelines for: nursing mothers;
mothers; pediatric patients Hypothyroidism (6–10%) pediatric patients
Genitourinary Note: Jalyn is dutasteride and tamsulosin.
Skin Urinary tract infection (15%)
Peripheral edema (15%) Hematologic Endocrine/Metabolic
Rash (11%) Anemia (8%) Gynecomastia [2]
Central Nervous System Lymphopenia (11%) Libido decreased (<3%) [3]
Fever (14%) Local Genitourinary
Neuromuscular/Skeletal Infusion-related reactions (2%) Ejaculatory dysfunction [3]
Asthenia (fatigue) (39%) Erectile dysfunction [8]
Other Impotence (<5%)
Bone or joint pain (24%) Death [2] Sexual dysfunction [6]
Gastrointestinal/Hepatic Infection (30–38%)
Abdominal pain (14%) Other
Colitis (13%) Adverse effects [2]
Litt’s Drug Eruption & Reaction Manual EFAVIRENZ
Skin
ECALLANTIDE EDARAVONE * Rash (4%)
See: www.drugeruptiondata.com/drug/id/1425 Trade name: Radicava (Mitsubishi Tanabe Mucosal
Pharma) Epistaxis (nosebleed) (5%)
Indications: Amyotrophic lateral sclerosis Gingival bleeding [2]
Oral bleeding (3%)
ECONAZOLE Class: Antioxidant
Half-life: 4–6 hours Gastrointestinal/Hepatic
See: www.drugeruptiondata.com/drug/id/1342 Clinically important, potentially hazardous Diarrhea [2]
interactions with: none known Gastrointestinal bleeding (4%)
Pregnancy category: N/A (May cause fetal Hepatotoxicity (5–8%) [2]
toxicity based on findings in animal studies )
ECULIZUMAB Important contra-indications noted in the
Genitourinary
Hematuria (2%) [2]
Trade name: Soliris (Alexion) pediatric patients Hematologic
Indications: Paroxysmal nocturnal Note: Radicava contains sodium bisulfite which Anemia (2–10%)
hemoglobinuria, atypical hemolytic uremic may cause allergic type reactions. Bleeding (>5%) [13]
syndrome Other
Class: Complement inhibitor, Monoclonal Adverse effects [4]
antibody Skin
Half-life: ~12 days Dermatitis (8%)
Clinically important, potentially hazardous Eczema (7%) [2]
interactions with: none known Hematoma (15%) [2] EDROPHONIUM
Pregnancy category: C Tinea (4%)
Important contra-indications noted in the Central Nervous System See: www.drugeruptiondata.com/drug/id/251
prescribing guidelines for: nursing mothers; Gait instability (13%) [2]
pediatric patients Headache (10%) [2]
Warning: SERIOUS MENINGOCOCCAL Insomnia [2] EFALIZUMAB
INFECTIONS Gastrointestinal/Hepatic
Constipation [2] See: www.drugeruptiondata.com/drug/id/1004
Skin Diarrhea [2]
Peripheral edema [2] Dysphagia [3]
Pruritus [2] Hepatotoxicity [2] EFAVIRENZ
Mucosal Respiratory
Nasal congestion [2] Hypoxia (6%) Trade names: Atripla (Gilead), Sustiva (Bristol-
Nasopharyngitis [2] Myers Squibb)
Cardiovascular Indications: HIV infection
Hypertension [2] Respiratory failure (6%) [2]
Class: Antiretroviral, CYP1A2 inhibitor, CYP3A4
Central Nervous System Genitourinary inducer, Non-nucleoside reverse transcriptase
Fever [3] Glycosuria (4%) [2] inhibitor
Headache (44%) [5] Renal Half-life: 52–76 hours
Insomnia [2] Nephrotoxicity [2] Clinically important, potentially hazardous
Meningococcal infection [4] Other interactions with: alcohol, alprazolam,
Vertigo (dizziness) [3] Adverse effects [2] amprenavir, aripiprazole, artesunate, atazanavir,
Neuromuscular/Skeletal atorvastatin, atovaquone, benzodiazepines,
Asthenia (fatigue) (12%) [4] bepridil, boceprevir, bortezomib, brentuximab
Back pain (19%) [3] vedotin, budesonide, buprenorphine, bupropion,
Pain in extremities [2]
EDOXABAN carbamazepine, carvedilol, caspofungin,
chlordiazepoxide, cisapride, citalopram,
Gastrointestinal/Hepatic Trade name: Savaysa (Daiichi Sankyo) clarithromycin, clonazepam, clopidogrel,
Abdominal pain [2] Indications: Reduce the risk of stroke and clorazepate, CNS depressants, cobimetinib,
Diarrhea [3] systemic embolism in patients with nonvalvular colchicine, conivaptan, crizotinib, cyclosporine,
Nausea [4] atrial fibrillation, treatment of deep vein CYP2B6 inhibitors and inducers, CYP2C19
Vomiting [3] thrombosis and pulmonary embolism substrates, CYP2C9 substrates, CYP3A4
Respiratory Class: Direct factor Xa inhibitor substrates and inducers, darunavir, dasabuvir/
Cough (12%) [4] Half-life: 10–14 hours ombitasvir/paritaprevir/ritonavir, dasatinib,
Nasopharyngitis (23%) [5] Clinically important, potentially hazardous deferasirox, deflazacort, diazepam,
Pharyngolaryngeal pain [2] interactions with: anticoagulants, rifampin dihydroergotamine, diltiazem, dronedarone,
Upper respiratory tract infection [2] Pregnancy category: C elbasvir & grazoprevir, enzalutamide, eplerenone,
Important contra-indications noted in the ergot, etravirine, everolimus, exemestane,
Genitourinary prescribing guidelines for: nursing mothers;
Urinary tract infection [3] fentanyl, flurazepam, fosamprenavir,
pediatric patients fosphenytoin, gefitinib, glecaprevir & pibrentasvir,
Hematologic Note: Contra-indicated in patients with active grapefruit juice, guanfacine, halofantrine,
Anemia [2] pathological bleeding. hydroxyzine, imatinib, indinavir, itraconazole,
Leukopenia [2] Warning: REDUCED EFFICACY IN ixabepilone, lapatinib, levomepromazine,
NONVALVULAR ATRIAL FIBRILLATION levonorgestrel, linagliptin, lopinavir, lorazepam,
PATIENTS WITH CRCL>95ml/min lovastatin, lurasidone, maraviroc, methadone,
ISCHEMIC EVENTS ON PREMATURE methysergide, midazolam, mifepristone,
DISCONTINUATION neratinib, nevirapine, nifedipine, nilotinib,
SPINAL/EDPIDURAL HEMATOMA nisoldipine, olaparib, ombitasvir/paritaprevir/
ritonavir, oral contraceptives, oxazepam,
EFAVIRENZ See all our books at www.crcpress.com
paclitaxel, palbociclib, pazopanib, phenytoin, Tremor (<2%) Xerosis (2%)

pimecrolimus, pimozide, posaconazole, Vertigo (dizziness) (2–9%) [15] Hair
pravastatin, praziquantel, progestogens, Neuromuscular/Skeletal Alopecia (510%)
propafenone, protease inhibitors, quazepam, Asthenia (fatigue) (2–8%) [3] Ingrown (2%)
raltegravir, ranolazine, rifabutin, rifampin, Myalgia/Myopathy (<2%) Pseudofolliculitis barbae (515%)
rilpivirine, ritonavir, rivaroxaban, roflumilast,
romidepsin, salmeterol, saquinavir, saxagliptin, Gastrointestinal/Hepatic Central Nervous System
sertraline, simeprevir, simvastatin, sirolimus, Abdominal pain (2–3%) Headache (5%)
sofosbuvir & velpatasvir, sofosbuvir/velpatasvir/ Diarrhea (3–14%) [2] Paresthesias (4%)
voxilaprevir, sonidegib, sorafenib, SSRIs, St John’s Dyspepsia (4%) Seizures (7%) [2]
wort, sunitinib, tacrolimus, tadalafil, telaprevir, Hepatic failure [2] Vertigo (dizziness) (<10%)
temazepam, ticagrelor, tipranavir, tocilizumab, Hepatotoxicity [13] Gastrointestinal/Hepatic
tolvaptan, toremifene, triazolam, ulipristal, Nausea (2–10%) [3] Diarrhea (<10%)
vandetanib, vemurafenib, venetoclax, vilazodone, Vomiting (3–6%) Vomiting (<10%)
vitamin K antagonists, voriconazole, warfarin, Endocrine/Metabolic Hematologic
zuclopenthixol ALT increased [2] Eosinophilia (<10%)
Pregnancy category: D Gynecomastia [14]
Important contra-indications noted in the Otic
Genitourinary Hearing impairment (<10%)
prescribing guidelines for: the elderly; nursing Urolithiasis [3]
Note: Atripla is efavirenz, emtricitabine and Hematologic
tenofovir disoproxil. Dyslipidemia [2] ELBASVIR &
Other
Skin Adverse effects [10] GRAZOPREVIR
DRESS syndrome [2] Teratogenicity [4]
Trade name: Zepatier (Merck)
Eczema (<2%)
Indications: Chronic hepatitis C virus genotypes
Erythema (11%)
1 or 4 (with or without ribavirin)
Exanthems (27%) [3] EFINACONAZOLE Class: Direct-acting antiviral, Hepatitis C virus
Exfoliative dermatitis (<2%)
NS3/4A protease inhibitor (grazoprevir),
Folliculitis (<2%) Trade name: Jublia (Valeant)
Hepatitis C virus NS5A inhibitor (elbasvir)
Hot flashes (<2%) Indications: Onychomycosis
Half-life: 24 hours (elbasvir); 31 hours
Hypersensitivity [5] Class: Antifungal
(grazoprevir)
Lipodystrophy [2] Half-life: 30 hours
Peripheral edema (<2%) Clinically important, potentially hazardous
interactions with: atazanavir, atorvastatin,
Photosensitivity [4] interactions with: none known
bosentan, carbamazepine, cobicistat/elvitegravir/
Pruritus (11%) Pregnancy category: C
emtricitabine/tenofovir disoproxil, cyclosporine,
Rash (26%) [16] Important contra-indications noted in the
darunavir, efavirenz, fluvastatin, ketoconazole,
Stevens-Johnson syndrome [3] prescribing guidelines for: nursing mothers;
lopinavir, lovastatin, modafinil, moderate CYP3A
Toxicity [2] pediatric patients
inducers, nafcillin, OATP1B1/3 inhibitors,
Urticaria (<2%)
phenytoin, rifampin, rosuvastatin, saquinavir,
Hair Nails simvastatin, strong CYP3A inducers, tacrolimus,
Alopecia (<2%) Onychocryptosis (2%) tipranavir
Mucosal Local Pregnancy category: N/A (No available data;
Xerostomia (<2%) Application-site dermatitis (2%) contra-indicated in pregnant women and in men
Application-site reactions [4] with pregnant partners when administered with
Cardiovascular
Application-site vesicles (2%) ribavirin)
Flushing (<2%)
Thrombophlebitis (<2%)
Central Nervous System Note: Contra-indicated in patients with
Abnormal dreams (<3%) [9] EFLORNITHINE moderate or severe hepatic impairment (Child-
Aggression [2] Pugh B or C).
Anorexia (<2%) Trade name: Vaniqa (Women First)
Anxiety (13%) [4] Indications: Sleeping sickness, hypertrichosis
Class: Ornithine decarboxylase inhibitor Central Nervous System
Depression (19%) [9]
Half-life: 3–3.5 hours (intravenous); 8 hours Headache (10–11%) [8]
Dysgeusia (taste perversion) (<2%)
Hallucinations [2] (topical) Neuromuscular/Skeletal
Headache (2–8%) [2] Clinically important, potentially hazardous Asthenia (fatigue) (5–11%) [8]
Impaired concentration (3–5%) [4] interactions with: none known
Insomnia (7%) [4] Pregnancy category: C
Abdominal pain (2%)
Nervousness (7%) Important contra-indications noted in the
Diarrhea (2%) [2]
Neuropsychiatric disturbances [2] prescribing guidelines for: nursing mothers;
Nausea (11%) [7]
Neurotoxicity [14] pediatric patients
Nightmares [3]
Pain (<13%) Skin
Paresthesias (<2%) Acneform eruption (24%)
Parosmia (<2%) Burning (4%)
Psychosis [6] Facial edema (3%)
Sleep related disorder [2] Pruritus (4%) [2]
Somnolence (drowsiness) (2%) [3] Rash (3%)
Suicidal ideation [5] Stinging (8%)
Litt’s Drug Eruption & Reaction Manual ELOTUZUMAB
Cardiovascular Pregnancy category: N/A (Embryo-fetal toxicity

ELETRIPTAN Palpitation (5%) [3] with combination dosage)
Trade name: Relpax (Pfizer) prescribing guidelines for: nursing mothers;
Indications: Migraine headaches Headache (13–40%) [2]
Migraine (10%) pediatric patients
Class: 5-HT1 agonist, Serotonin receptor agonist, Note: See separate entries for dexamethasone
Triptan Vertigo (dizziness) (8%)
and lenalidomide.
Half-life: 4–5 hours Neuromuscular/Skeletal
Clinically important, potentially hazardous Asthenia (fatigue) (8–14%)
interactions with: clarithromycin, Back pain (12%) Skin
dihydroergotamine, itraconazole, ketoconazole, Pain in extremities (11%) Herpes zoster (14%)
methysergide, nefazodone, nelfinavir, paclitaxel, Hyperhidrosis (>5%)
Gastrointestinal/Hepatic Hypersensitivity (>5%) [2]
ritonavir, SNRIs, SSRIs, telithromycin, triptans, Abdominal pain (10%) [2]
troleandomycin, voriconazole Peripheral edema [5]
Constipation (5%) Rash [2]
Pregnancy category: C Diarrhea (12%) [2]
Important contra-indications noted in the Dyspepsia (7%) Mucosal
prescribing guidelines for: nursing mothers; Flatulence (10%) Oropharyngeal pain (10%)
pediatric patients Gastroesophageal reflux (7%) Cardiovascular
Note: Contra-indicated in patients with history, Nausea (10–12%) Chest pain (>5%) [3]
symptoms, or signs of ischemic cardiac, Flushing [2]
cerebrovascular, or peripheral vascular Respiratory
Cough (7%) Tachycardia [2]
syndromes, or in patients with uncontrolled
hypertension. Other Central Nervous System
Adverse effects [2] Anorexia [3]
Chills [4]
Mucosal Fever (37%) [6]
Xerostomia (2–4%) Headache (15%) [5]
Cardiovascular ELOSULFASE ALFA Hypoesthesia (>5%)
Chest pain (<4%) [3] Insomnia [4]
Flushing (2%) Trade name: Vimizim (BioMarin) Mood changes (>5%)
Indications: Mucopolysaccharidosis IVA Neurotoxicity [2]
Central Nervous System (Morquio A syndrome)
Headache (3–4%) Peripheral neuropathy (27%) [3]
Class: Enzyme
Neurotoxicity [2] Half-life: 8–36 minutes Neuromuscular/Skeletal
Paresthesias (3–4%) Clinically important, potentially hazardous Arthralgia [2]
Somnolence (drowsiness) (3–7%) [2] interactions with: none known Asthenia (fatigue) (62%) [10]
Vertigo (dizziness) (3–7%) Pregnancy category: C Back pain [3]
Warm feeling (2%) Important contra-indications noted in the Muscle spasm [3]
Neuromuscular/Skeletal prescribing guidelines for: nursing mothers; Pain in extremities (16%)
Asthenia (fatigue) (4–10%) [4] pediatric patients Gastrointestinal/Hepatic
Gastrointestinal/Hepatic Warning: RISK OF ANAPHYLAXIS Constipation (36%) [4]
Abdominal pain (<2%) Diarrhea (47%) [6]
Dyspepsia (<2%) Skin Nausea [5]
Dysphagia (<2%) Anaphylactoid reactions/Anaphylaxis (8%) Vomiting (15%) [4]
Nausea (3–7%) [5] Hypersensitivity (19%) Respiratory
Vomiting [2] Central Nervous System Cough [3]
Other Chills (10%) Dyspnea [5]
Adverse effects [2] Fever (33%) Nasopharyngitis (25%)
Headache (26%) Pneumonia (20%) [5]
ELIGLUSTAT Asthenia (fatigue) (10%) Endocrine/Metabolic
ALP increased (39%)
Gastrointestinal/Hepatic Appetite decreased (21%)
Trade name: Cerdelga (Genzyme) Abdominal pain (21%)
Indications: Gaucher disease Hyperglycemia (89%) [2]
Nausea (24%) Hyperkalemia (32%)
Class: Glucosylceramide synthase inhibitor Vomiting (31%) [2]
Half-life: 7–9 hours Hypocalcemia (78%)
Clinically important, potentially hazardous Local Hypokalemia [4]
interactions with: carbamazepine, grapefruit Infusion-related reactions [2] Serum creatinine increased [3]
juice, phenobarbital, phenytoin, rifampin, St John’s Weight loss (14%) [2]
wort, strong or moderate CYP2D6 inhibitors Hematologic
Pregnancy category: C ELOTUZUMAB Anemia [4]
Important contra-indications noted in the Leukopenia (91%) [3]
prescribing guidelines for: nursing mothers; Trade name: Empliciti (Bristol-Myers Squibb) Lymphocytopenia [3]
pediatric patients Indications: Multiple myeloma (in combination Lymphopenia (13–99%) [4]
with lenalidomide and dexamethasone) in patients Neutropenia [8]
Skin who have received one to three prior therapies Thrombocytopenia (84%) [5]
Rash (5%) Class: Monoclonal antibody Ocular
Half-life: N/A Cataract (12%)
Mucosal Clinically important, potentially hazardous
Oropharyngeal pain (10%) interactions with: none known Local
Infusion-related reactions (10%) [10]
ELTROMBOPAG Over 100 updates per week on www.drugeruptiondata.com
Neutropenia [2] AST increased (<2%)

ELTROMBOPAG Thrombocytopenia [2] Other
Thrombosis [5] Adverse effects [2]
Trade names: Promacta (Novartis), Revolade
(Novartis) Ocular
Indications: Thrombocytopenic purpura, severe Cataract (5%) [2]
aplastic anemia in patients with insufficient Other EMPAGLIFLOZIN
response to immunosuppressive therapy Adverse effects [8]
Class: Thrombopoietin receptor (TPO) agonist Trade names: Glyxambi (Boehringer Ingelheim),
Half-life: 2132 hours Jardiance (Boehringer Ingelheim), Synjardy
interactions with: antacids, atorvastatin, dairy
ELUXADOLINE (Boehringer Ingelheim)
products, eluxadoline, lopinavir, mineral Trade name: Viberzi (Forest) Class: Sodium-glucose co-transporter 2 (SGLT2)
supplements, olmesartan, rosuvastatin, selenium, Indications: Irritable bowel syndrome with inhibitor
zinc diarrhea Half-life: 12 hours
Pregnancy category: C Class: Opioid mu receptor agonist Clinically important, potentially hazardous
Important contra-indications noted in the Half-life: 4–6 hours interactions with: none known
prescribing guidelines for: nursing mothers; Clinically important, potentially hazardous Pregnancy category: C
pediatric patients interactions with: alfentanil, alosetron, Important contra-indications noted in the
Warning: RISK FOR HEPATIC anticholinergics, atazanavir, bupropion, prescribing guidelines for: nursing mothers;
DECOMPENSATION IN PATIENTS WITH ciprofloxacin, clarithromycin, cyclosporine, pediatric patients
CHRONIC HEPATITIS C dihydroergotamine, eltrombopag, ergotamine, Note: Contra-indicated in patients with severe
fentanyl, fluconazole, gemfibrozil, lopinavir, renal impairment, end stage renal disease, or on
Skin opioids, paroxetine hydrochloride, paroxetine dialysis. Glyxambi is empagliflozin and linagliptin;
Peripheral edema (3–4%) mesylate, pimozide, quinidine, rifampin, ritonavir, Synjardy is empagliflozin and metformin.
Pigmentation [2] rosuvastatin, saquinavir, sirolimus, tacrolimus,
Rash (3–7%) tipranavir Central Nervous System
Hair Pregnancy category: N/A (Insufficient evidence Headache [2]
Alopecia (2%) to inform drug-associated risk) Gastrointestinal/Hepatic
Important contra-indications noted in the Constipation [2]
Mucosal prescribing guidelines for: pediatric patients
Oropharyngeal pain (4%) Note: Contra-indicated in patients with known Respiratory
Xerostomia (2%) or suspected biliary duct obstruction, or sphincter Nasopharyngitis [4]
Cardiovascular of Oddi disease or dysfunction; alcoholism, Endocrine/Metabolic
Thromboembolism [5] alcohol abuse, alcohol addiction, or drink more Hypoglycemia [3]
Venous thromboembolism [2] than 3 alcoholic beverages/day; a history of Genitourinary
pancreatitis; structural diseases of the pancreas,
Central Nervous System Genital mycotic infections (2–6%) [7]
including known or suspected pancreatic duct Pollakiuria [3]
obstruction; severe hepatic impairment (Child- Urinary frequency (3%)
Headache (10–21%) [10]
Pugh Class C); severe constipation or sequelae Urinary tract infection (8–9%) [7]
Paresthesias (3%)
from constipation, or known or suspected
Neuromuscular/Skeletal mechanical gastrointestinal obstruction. Other
Arthralgia (3%) [2] Adverse effects [7]
Asthenia (fatigue) (3–4%) [4] Dipsia (thirst) (2%)
Back pain (3%)
Skin
Rash (3%)
Pain in extremities (7%) Central Nervous System EMTRICITABINE
Gastrointestinal/Hepatic Euphoria (<2%)
Sedation (<2%) Trade names: Atripla (Gilead), Complera
Abdominal pain [2]
Somnolence (drowsiness) (<2%) (Gilead), Descovy (Gilead), Emtriva (Gilead),
Constipation [2]
Vertigo (dizziness) (3%) [2] Truvada (Gilead)
Diarrhea (9%)
Hepatotoxicity [3] Gastrointestinal/Hepatic Indications: HIV-1 infection
Nausea (4–9%) [5] Abdominal distension (3%) [2] Class: Antiretroviral, Nucleoside analog reverse
Vomiting (6%) Abdominal pain (6–7%) [4] transcriptase inhibitor
Respiratory Constipation (7–8%) [7] Half-life: ~10 hours
Flatulence (3%) Clinically important, potentially hazardous
Cough (5%)
Gastroenteritis (<3%) [2] interactions with: cobicistat/elvitegravir/
Nasopharyngitis [2]
Gastroesophageal reflux (<2%) emtricitabine/tenofovir disoproxil, ganciclovir,
Pharyngitis (4%)
Nausea (7–8%) [5] lamivudine, ribavirin, valganciclovir
Upper respiratory tract infection (7%)
Pancreatitis [5] Pregnancy category: B
Endocrine/Metabolic Vomiting (4%) [3] Important contra-indications noted in the
ALP increased (2%) prescribing guidelines for: nursing mothers
ALT increased (5–6%) [4]
Respiratory
Asthma (<2%) Note: Emtricitabine is a fluorinated derivative of
AST increased (4%) lamivudine. Atripla is emtricitabine, efavirenz and
Bronchitis (3%)
Genitourinary Bronchospasm (<2%) tenofovir disoproxil; Complera is emtricitabine,
Urinary tract infection (5%) Nasopharyngitis (3–4%) [2] rilpivirine and tenofovir disoproxil; Descovy is
Respiratory failure (<2%) emtricitabine and tenofovir alafenamide; Truvada
Renal
Wheezing (<2%) is emtricitabine and tenofovir disoproxil. See also
Renal failure [3]
separate profiles for emtricitabine in combination
Hematologic Endocrine/Metabolic with cobicistat, elvitegravir and tenofovir
Bleeding [3] ALT increased (2–3%) disoproxil or tenofovir alafenamide.
Litt’s Drug Eruption & Reaction Manual ENALAPRIL
Warning: LACTIC ACIDOSIS / SEVERE sulfonylureas, tadalafil, temsirolimus, tizanidine,

HEPATOMEGALY WITH STEATOSIS and POST EMTRICITABINE/ tolvaptan, triamterene, trimethoprim
TREATMENT EXACERBATION OF HEPATITIS Pregnancy category: D (category C in first
B
RILPIVIRINE/ trimester; category D in second and third
TENOFOVIR trimesters)
Skin
Exanthems (17%) ALAFENAMIDE prescribing guidelines for: nursing mothers
Pigmentation (palms and soles) (32%) Note: Lexxel is enalapril and felodipine; Teczem
Pruritus (17–30%) Trade name: Odefsey (Gilead) is enalapril and diltiazem; Vaseretic is enalapril and
Pustules (17–30%) Indications: HIV-1 infection hydrochlorothiazide. Hydrochlorothiazide is a
Rash (17–30%) [5] Class: Hepatitis B virus necleoside analog reverse sulfonamide and can be absorbed systemically.
Urticaria (17–30%) transcriptase inhibitor (tenofovir alafenamide), Sulfonamides can produce severe, possibly fatal,
Vesiculobullous eruption (17–30%) Non-nucleoside reverse transcriptase inhibitor reactions such as toxic epidermal necrolysis and
(rilpivirine), Nucleoside analog reverse Stevens-Johnson syndrome.
Central Nervous System transcriptase inhibitor (emtricitabine) Contra-indicated in patients with a history of
Abnormal dreams (2–11%) [3] Half-life: 10 hours (emtricitabine); 50 hours angioedema with or without previous ACE
Anxiety [2] (rilpivirine); <1 hour (tenofovir alafenamide) inhibitor treatment.
Depression (6–9%) Clinically important, potentially hazardous Warning: FETAL TOXICITY
Fever (18%) interactions with: carbamazepine,
Headache (13–22%) [5] dexamethasone, dexlansoprazole, esomeprazole,
Insomnia (7–16%) Skin
lansoprazole, omeprazole, oxcarbazepine, Angioedema [73]
Neurotoxicity [5] pantoprazole, phenobarbital, phenytoin,
Paresthesias (6%) Bullous pemphigoid [2]
rabeprazole, rifampin, rifapentine, St John’s wort Exanthems [9]
Peripheral neuropathy (4%) Pregnancy category: N/A (Insufficient evidence
Somnolence (drowsiness) [2] Lichenoid eruption [2]
to inform drug-associated risk) Lupus erythematosus [2]
Vertigo (dizziness) (4–25%) [4] Important contra-indications noted in the Pemphigus [10]
Neuromuscular/Skeletal prescribing guidelines for: nursing mothers; Pemphigus foliaceus [2]
Arthralgia (3–5%) pediatric patients Peripheral edema [2]
Asthenia (fatigue) (12–16%) [4] Warning: LACTIC ACIDOSIS/SEVERE Photosensitivity [2]
Myalgia/Myopathy (4–6%) [2] HEPATOMEGALY WITH STEATOSIS and POST Pruritus [3]
Gastrointestinal/Hepatic TREATMENT ACUTE EXACERBATION OF Psoriasis [3]
Abdominal pain (8–14%) [2] HEPATITIS B Rash [5]
Diarrhea (20–23%) [6] Urticaria [5]
Dyspepsia (4–8%) Central Nervous System Vasculitis [2]
Gastroenteritis (11%) Depression (<2%) Mucosal
Hepatic failure [2] Headache (<2%) Oral lesions [4]
Hepatotoxicity [2] Insomnia (<2%) Oral ulceration [2]
Nausea (13–18%) [7] Tongue edema [2]
Vomiting (9–23%) [4]
Cardiovascular
Respiratory ENALAPRIL Flushing [4]
Cough (14–28%) Hypotension [2]
Pneumonia (15%) Trade names: Innovace (Merck Sharpe &
Rhinitis (12–20%) Dohme), Lexxel (AstraZeneca), Teczem (Sanofi- Central Nervous System
Aventis), Vaseretic (Valeant), Vasotec (Valeant) Ageusia (taste loss) [4]
Hematologic Dysgeusia (taste perversion) (<10%) [7]
Anemia (7%) Indications: Hypertension, symptomatic
congestive heart failure, asymptomatic left Headache (5%)
Otic ventricular dysfunction Vertigo (dizziness) (4–8%) [2]
Otitis media (23%) Class: Angiotensin-converting enzyme (ACE) Neuromuscular/Skeletal
Other inhibitor, Antihypertensive, Vasodilator Asthenia (fatigue) (<3%)
Adverse effects [5] Half-life: 11 hours Pseudopolymyalgia [2]
Allergic reactions (17–30%) Clinically important, potentially hazardous Gastrointestinal/Hepatic
Infection (44%) interactions with: alcohol, aldesleukin, Hepatotoxicity [3]
allopurinol, alpha blockers, alprostadil, amifostine, Pancreatitis [2]
amiloride, angiotensin II receptor antagonists,
antacids, antidiabetics, antihypertensives, Respiratory
antipsychotics, anxiolytics and hypnotics, Cough (823%) [40]
aprotinin, azathioprine, baclofen, beta blockers, Endocrine/Metabolic
calcium channel blockers, clonidine, conivaptan, Hyperkalemia [4]
corticosteroids, cyclosporine, CYP3A4 inducers, SIADH [3]
deferasirox, diazoxide, diuretics, eplerenone, Renal
estrogens, everolimus, general anesthetics, gold & Nephrotoxicity [2]
gold compounds, grapefruit juice, heparins,
hydralazine, hypotensives, insulin, levodopa, Other
lithium, MAO inhibitors, metformin, methyldopa, Adverse effects [9]
methylphenidate, minoxidil, moxisylyte, Death [4]
moxonidine, nitrates, nitroprusside, NSAIDs,
pentoxifylline, phosphodiesterase 5 inhibitors,
potassium salts, prostacyclin analogues, quinine,
rituximab, salicylates, sirolimus, spironolactone,
ENASIDENIB See all our books at www.crcpress.com
Mucosal molecular weight heparins or heparinoids and are

ENASIDENIB * Xerostomia (2%) receiving neuraxial anesthesia or undergoing
Central Nervous System spinal puncture.
Trade name: Idhifa (Celgene) Contra-indicated in patients with active major
Indications: Relapsed or refractory acute Anorexia (2%)
Depression (9%) bleeding; thrombocytopenia with a positive in
myeloid leukemia vitro test for anti-platelet antibody in the presence
Class: Isocitrate dehydrogenase-2 inhibitor Neuromuscular/Skeletal of enoxaparin; hypersensitivity to heparin or pork
Half-life: 137 hours Asthenia (fatigue) (16%) [2] products; hypersensitivity to benzyl alcohol
Clinically important, potentially hazardous Myalgia/Myopathy (3%) (multi-dose formulation only).
interactions with: none known Pain in extremities (3%) Warning: SPINAL/EPIDURAL HEMATOMA
Pregnancy category: N/A (Can cause fetal Gastrointestinal/Hepatic
harm) Abdominal pain (4%)
Pancreatitis (3%) Anaphylactoid reactions/Anaphylaxis [3]
pediatric patients Respiratory Angioedema [2]
Warning: DIFFERENTIATION SYNDROME Cough (4%) Bullous dermatitis [7]
Flu-like syndrome (2%) Ecchymoses (2%)
Pneumonia (3%) Edema (3%)
Skin Sinusitis (6%) Erythema (<10%) [2]
Differentiation syndrome (14%) Exanthems [2]
Tumor lysis syndrome (6%) Endocrine/Metabolic
Hematoma [11]
ALT increased (<4%)
Cardiovascular Hypersensitivity [7]
Appetite decreased (3%)
Pulmonary edema (<10%) Necrosis [4]
Creatine phosphokinase increased (3–7%)
Central Nervous System Peripheral edema (3%)
Weight loss (7%)
Dysgeusia (taste perversion) (12%) Pruritus [2]
Hematologic Purpura (<10%)
Gastrointestinal/Hepatic Eosinophilia (2–9%)
Diarrhea (43%)
Cardiovascular
Ocular Venous thromboembolism [2]
Nausea (50%) Conjunctivitis (2%)
Vomiting (34%) Gastrointestinal/Hepatic
Local Hepatotoxicity [5]
Respiratory Injection-site bruising (52%)
Acute respiratory distress syndrome Endocrine/Metabolic
Injection-site erythema (91%)
(<10%) ALT increased [4]
Injection-site induration (90%)
Endocrine/Metabolic AST increased [3]
Injection-site nodules (80%) [4]
Appetite decreased (34%) Injection-site pain (96%) Genitourinary
Hyperbilirubinemia (81%) Injection-site pruritus (65%) Hematuria [2]
Hypocalcemia (74%) Injection-site reactions (98%) [27] Hematologic
Hypokalemia (41%) Injection-site scleroderma [2] Bleeding [8]
Hypophosphatemia (27%) Other Hemorrhage [4]
Hematologic Infection [3] Thrombocytopenia [5]
Leukocytosis (12%) Local
Injection-site necrosis [4]
ENOXACIN Injection-site plaques [2]
ENFLURANE Other
See: www.drugeruptiondata.com/drug/id/879 Death [2]
ENOXAPARIN
ENFUVIRTIDE ENTACAPONE
Trade names: Clexane (Sanofi-Aventis), Lovenox
Trade name: Fuzeon (Roche) (Sanofi-Aventis) Trade names: Comtan (Orion), Comtess
Indications: HIV-1 infection (in combination with Indications: Prevention of deep vein thrombosis, (Orion), Stalevo (Orion)
other antiretroviral agents) ischemic complications of unstable angina and Indications: Parkinsonism
Class: Antiretroviral, HIV cell fusion inhibitor non-Q wave myocardial infarction, treatment of Class: Catechol-O-methyl transferase inhibitor
Half-life: 3.8 hours acute ST-segment elevation myocardial infarction Half-life: 2.4 hours
Clinically important, potentially hazardous Class: Heparin, low molecular weight Clinically important, potentially hazardous
interactions with: darunavir, indinavir, tipranavir Half-life: 4.5 hours interactions with: amitriptyline, MAO
Pregnancy category: B Clinically important, potentially hazardous inhibitors, paroxetine hydrochloride, phenelzine,
Important contra-indications noted in the interactions with: ACE inhibitors, angiotensin II rasagiline, tranylcypromine, venlafaxine
prescribing guidelines for: the elderly; nursing receptor antagonists, anticoagulants, aspirin, Pregnancy category: C
mothers butabarbital, clopidogrel, danaparoid, diclofenac, Important contra-indications noted in the
dipyridamole, drotrecogin alfa, iloprost, infused prescribing guidelines for: nursing mothers;
Skin nitrates, ketorolac, NSAIDs, platelet inhibitors, pediatric patients
Folliculitis (2%) rivaroxaban, salicylates, sulfinpyrazone
Herpes simplex (4%) Pregnancy category: B
Hypersensitivity [3] Diaphoresis (2%)
Papillomas (4%) prescribing guidelines for: nursing mothers;
pediatric patients Purpura (2%)
Pruritus (62%)
Note: Epidural or spinal hematomas may occur Mucosal
in patients who are anticoagulated with low Xerostomia (3%)
Litt’s Drug Eruption & Reaction Manual EPINEPHRINE
Central Nervous System Genitourinary Upper respiratory tract infection (11%) [3]
Anxiety (2%) Hematuria (9%) Endocrine/Metabolic
Dyskinesia (25%) [3] Other ALT increased (10%)
Hyperactivity (10%) Adverse effects [4] Appetite decreased [5]
Hypokinesia (9%) Gynecomastia [2]
Parkinsonism (17%) Weight loss [3]
Somnolence (drowsiness) (2%)
Vertigo (dizziness) (8%) [2] ENZALUTAMIDE Genitourinary
Hematuria (7%)
Neuromuscular/Skeletal Trade name: Xtandi (Medivation) Pollakiuria (5%)
Asthenia (fatigue) (8%) Indications: Metastatic castration-resistant
Back pain (4%) Hematologic
prostate cancer in patients who have previously Anemia [2]
Gastrointestinal/Hepatic received docetaxel Neutropenia (15%)
Abdominal pain (8%) Class: Androgen antagonist
Constipation (6%) Half-life: 8–9 days Other
Diarrhea (10%) [3] Clinically important, potentially hazardous Adverse effects [4]
Dyspepsia (2%) interactions with: alfentanil, bosentan,
Flatulence (2%) carbamazepine, copanlisib, cyclosporine,
Nausea (14%) [3] dihydroergotamine, efavirenz, ergotamine, EPHEDRINE
Vomiting (4%) fentanyl, gemfibrozil, itraconazole, midazolam,
Respiratory midostaurin, modafinil, nafcillin, neratinib, Trade names: Rynatuss (MedPointe), Vicks
Dyspnea (3%) omeprazole, phenobarbital, phenytoin, pimozide, Vatronol (Procter & Gamble)
quinidine, rifabutin, rifampin, rifapentine, Indications: Nasal congestion, acute hypotensive
Genitourinary sirolimus, St John’s wort, tacrolimus, warfarin states, asthma
Melanuria (10%) [2] Pregnancy category: X (not indicated for use in Class: Adrenergic alpha-receptor agonist,
women) Sympathomimetic
ENTECAVIR prescribing guidelines for: nursing mothers; Clinically important, potentially hazardous
pediatric patients interactions with: antihypertensives,
Trade name: Baraclude (Bristol-Myers Squibb) dexamethasone, furazolidone, guanethidine,
Indications: Chronic hepatitis B virus infection Skin iobenguane, levomepromazine, MAO inhibitors,
Class: Antiviral, Guanosine nucleoside analog Hot flashes (20%) [11] methyldopa, oxprenolol, phenelzine,
Half-life: ~24 hours Peripheral edema (15%) [3] phenylpropanolamine, selegiline,
Clinically important, potentially hazardous Pruritus (4%) tranylcypromine, tricyclic antidepressants
interactions with: none known Xerosis (4%) Pregnancy category: C
Pregnancy category: C Important contra-indications noted in the
Important contra-indications noted in the Mucosal prescribing guidelines for: nursing mothers
prescribing guidelines for: nursing mothers; Epistaxis (nosebleed) (3%)
pediatric patients Cardiovascular Skin
Warning: SEVERE ACUTE EXACERBATIONS Hypertension (6%) [5] Dermatitis [5]
OF HEPATITIS B, PATIENTS CO-INFECTED Central Nervous System Diaphoresis (<10%)
WITH HIV AND HBV, and LACTIC ACIDOSIS Amnesia (>2%) Fixed eruption [6]
AND HEPATOMEGALY Anxiety (7%) Pallor (<10%)
Cognitive impairment (4%) Urticaria [2]
Skin Gait instability [3] Mucosal
Rash [2] Hallucinations (2%) Xerostomia (<10%)
Hair Headache (12%) [4]
Hypoesthesia (4%) Central Nervous System
Alopecia [2] Trembling (<10%)
Insomnia (9%)
Central Nervous System Paresthesias (7%) [2] Tremor (<10%)
Headache (2–4%) [3] Seizures [12]
Neurotoxicity [3] Spinal cord compression (7%)
Peripheral neuropathy [2] Vertigo (dizziness) (10%) [2] EPINASTINE
Neuromuscular/Skeletal Neuromuscular/Skeletal
Asthenia (fatigue) (<3%) [6] Arthralgia (21%) [4] See: www.drugeruptiondata.com/drug/id/1013
Myalgia/Myopathy [3] Asthenia (fatigue) (51%) [22]
Gastrointestinal/Hepatic Back pain (26%) [5]
Abdominal pain [2] Bone or joint pain (15%) [7] EPINEPHRINE
Diarrhea [2] Fractures (4%) [2]
Pancreatitis [3] Gastrointestinal/Hepatic Synonym: adrenaline
Constipation [3] Trade names: Adrenaclick (Amedra), Adrenalin
Respiratory
Diarrhea (22%) [9] (JHP Pharmaceuticals), Auvi-Q (Sanofi-Aventis),
Cough [2]
Nausea [4] Epipen (Mylan)
Indications: Cardiac arrest, hay fever, asthma,
Endocrine/Metabolic Respiratory anaphylaxis
Acidosis [6] Bronchitis (>2%) Class: Catecholamine, Sympathomimetic
ALT increased (2–12%) [2] Laryngitis (>2%) Half-life: N/A
Creatine phosphokinase increased (<2%) Nasopharyngitis (>2%) Clinically important, potentially hazardous
Hypophosphatemia [2] Pharyngitis (>2%) interactions with: albuterol, alpha blockers,
Pneumonia (>2%) amitriptyline, amoxapine, atenolol, beta blockers,
Sinusitis (>2%)
EPINEPHRINE Over 100 updates per week on www.drugeruptiondata.com
carteolol, chlorpromazine, clomipramine, Stomatitis [9] Edema (17%)

clozapine, cocaine, desipramine, doxepin, Cardiovascular Pruritus (12–21%) [2]
ergotamine, furazolidone, halothane, imipramine, Cardiotoxicity [3] Rash (2–19%)
insulin aspart, insulin degludec, insulin detemir, QT prolongation [3] Cardiovascular
insulin glargine, insulin glulisine, levalbuterol, Hypertension (3–28%)
lisdexamfetamine, lurasidone, MAO inhibitors, Central Nervous System
metoprolol, milnacipran, nadolol, nortriptyline, Anorexia [5] Central Nervous System
oxprenolol, penbutolol, phenelzine, Dysgeusia (taste perversion) [2] Fever (10–42%) [2]
phenoxybenzamine, phenylephrine, pindolol, Fever [2] Headache (5–18%)
prazosin, propranolol, protriptyline, Headache [2] Paresthesias (11%)
sympathomimetics, terbutaline, thioridazine, Neurotoxicity [2] Neuromuscular/Skeletal
timolol, tranylcypromine, tricyclic Peripheral neuropathy [3] Arthralgia (10–16%)
antidepressants, trimipramine, vasopressors Neuromuscular/Skeletal Gastrointestinal/Hepatic
Pregnancy category: C Arthralgia [2] Constipation [2]
Important contra-indications noted in the Asthenia (fatigue) (6%) [9] Nausea (35–56%)
prescribing guidelines for: the elderly Myalgia/Myopathy (55%) [5]
Respiratory
Gastrointestinal/Hepatic Cough (4–26%)
Skin Abdominal pain [2] Dyspnea [2]
Dermatitis [4] Constipation [2]
Diaphoresis (<10%) Diarrhea [7] Hematologic
Necrosis [3] Hepatotoxicity [2] Thrombocytopenia [2]
Pemphigus (cicatricial) [2] Nausea [12] Ocular
Cardiovascular Vomiting [11] Hallucinations, visual [2]
Arrhythmias [3] Endocrine/Metabolic Local
Chest pain [2] ALT increased [2] Injection-site reactions (7%)
Flushing (<10%) Amenorrhea [2]
Hypertension [3] AST increased [2]
Hypotension [3]
Hematologic EPOPROSTENOL
Anemia [9]
Palpitation [2] Febrile neutropenia [5] Trade names: Flolan (GSK), Veletri (Actelion)
QT prolongation [2] Leukopenia [4] Indications: Pulmonary arterial hypertension
Ventricular tachycardia [2] Neutropenia [12] Class: Peripheral vasodilator
Central Nervous System Thrombocytopenia [5] Half-life: 6 minutes
Anxiety [2] Local Clinically important, potentially hazardous
Trembling (<10%) Injection-site reactions (320%) interactions with: anticoagulants,
Tremor [3] antihypertensives, diuretics, vasodilators
Other Pregnancy category: B
Allergic reactions [2] Important contra-indications noted in the
EPIRUBICIN prescribing guidelines for: the elderly; nursing
Trade name: Ellence (Pfizer) EPLERENONE Note: Contra-indicated in patients with heart
Indications: Adjuvant therapy in primary breast failure induced by reduced left ventricular ejection
cancer See: www.drugeruptiondata.com/drug/id/944 fraction.
Half-life: 33 hours Skin
Clinically important, potentially hazardous EPOETIN ALFA Diaphoresis (41%)
interactions with: amlodipine, bepridil, Pruritus (4%)
cimetidine, diltiazem, felodipine, isradipine, Synonyms: erythropoietin; EPO Rash (10%) [2]
nicardipine, nifedipine, nimodipine, nisoldipine, Trade names: Epogen (Amgen), Eprex (Janssen- Cardiovascular
verapamil Cilag), Procrit (Ortho) Bradycardia (5%) [2]
Pregnancy category: D Indications: Anemia Cardiac failure (31%)
Important contra-indications noted in the Class: Erythropoiesis-stimulating agent (ESA), Chest pain (11%) [2]
prescribing guidelines for: nursing mothers Erythropoietin Flushing [6]
Warning: SEVERE OR LIFE-THREATENING Half-life: 413 hours (in patients with chronic Hypotension (16%) [5]
HEMATOLOGICAL AND OTHER ADVERSE renal failure) Tachycardia (35%) [2]
REACTIONS Clinically important, potentially hazardous
interactions with: none known Central Nervous System
Pregnancy category: C Agitation (11%)
Skin Anxiety (21%) [2]
Erythroderma (5%) Important contra-indications noted in the
prescribing guidelines for: nursing mothers Chills (25%)
Hand–foot syndrome [5]
Warning: ERYTHROPOIESIS-STIMULATING Fever (25%)
Hot flashes (539%)
AGENTS (ESAs) INCREASE THE RISK OF Headache (83%) [13]
Pruritus (9%)
DEATH, MYOCARDIAL INFARCTION, Insomnia (9%)
Rash (<9%) [2]
STROKE, VENOUS THROMBOEMBOLISM, Paresthesias (12%)
Vasculitis [2]
THROMBOSIS OF VASCULAR ACCESS AND Seizures (4%)
Hair TUMOR PROGRESSION OR RECURRENCE Somnolence (drowsiness) (4%)
Alopecia (6995%) [17] Syncope (13%)
Mucosal Tremor (21%)
Skin
Mucositis [5] Angioedema (<5%)
Litt’s Drug Eruption & Reaction Manual ERIBULIN
Back pain (13%) EPTIFIBATIDE ERGOTAMINE
Jaw pain (54%) [6]
Myalgia/Myopathy (44%) Trade name: Integrilin (Merck) Trade name: Wigrettes (Organon)
Indications: Acute coronary syndrome, unstable Indications: Migraine, migraine variants
Gastrointestinal/Hepatic angina Class: Ergot alkaloid
Abdominal pain (14%) Class: Antiplatelet, Glycoprotein IIb/IIIa inhibitor Half-life: 2 hours
Diarrhea [2] Half-life: 2.5 hours Clinically important, potentially hazardous
Nausea [4] Clinically important, potentially hazardous interactions with: acebutolol, almotriptan,
Respiratory interactions with: anticoagulants, antiplatelet amprenavir, azithromycin, boceprevir, ceritinib,
Alveolar hemorrhage (pulmonary) [2] agents, collagenase, dasatinib, drotrecogin alfa, chlortetracycline, crizotinib, darunavir, dasabuvir/
Dyspnea (2%) fondaparinux, glucosamine, ibritumomab, ombitasvir/paritaprevir/ritonavir, dasatinib,
Flu-like syndrome (25%) iloprost, lepirudin, NSAIDs, pentoxifylline, delavirdine, demeclocycline, doxycycline,
Pneumonia [2] salicylates, thrombolytic agents, tositumomab & eluxadoline, enzalutamide, epinephrine,
Endocrine/Metabolic iodine131 erythromycin, indinavir, itraconazole, lopinavir,
Weight loss (27%) Pregnancy category: B lymecycline, methylergonovine, mifepristone,
Important contra-indications noted in the minocycline, naratriptan, nelfinavir, nilotinib,
Hematologic prescribing guidelines for: nursing mothers; ombitasvir/paritaprevir/ritonavir, oxytetracycline,
Sepsis (25%) pediatric patients posaconazole, propyphenazone, ribociclib,
Local Note: Contra-indicated in patients with a history ritonavir, telaprevir, telithromycin, tetracycline,
Injection-site infection (21%) of bleeding diathesis, or evidence of active tigecycline, tipranavir, troleandomycin,
Injection-site pain (13%) abnormal bleeding within the previous 30 days; voriconazole, warfarin
severe hypertension not adequately controlled on Pregnancy category: X
Other
antihypertensive therapy; major surgery within Important contra-indications noted in the
Adverse effects [3]
the preceding 6 weeks; history of stroke within prescribing guidelines for: nursing mothers
30 days or any history of hemorrhagic stroke; Note: Ergotamine is excreted in breast milk and
current or planned administration of another may cause symptoms of vomiting, diarrhea, weak
EPROSARTAN parenteral GP IIb/IIIa inhibitor; or dependency on pulse and unstable blood pressure in nursing
renal dialysis. infants.
Trade name: Teveten (AbbVie)
Indications: Hypertension
Class: Angiotensin II receptor antagonist
Cardiovascular Skin
(blocker), Antihypertensive
Hypotension (7%) Toxicity [4]
Half-life: 59 hours Hematologic Cardiovascular
Clinically important, potentially hazardous Bleeding [3] Valvulopathy [3]
interactions with: none known Hemorrhage (<10%) Respiratory
Pregnancy category: D (category C in first Thrombocytopenia [16] Pleural effusion [2]
trimester; category D in second and third Thrombosis [3]
trimesters) Other
Death [2] ERIBULIN
pediatric patients
Warning: FETAL TOXICITY Trade name: Halaven (Eisai)
ERDOSTEINE Indications: Metastatic breast cancer in patients
who have previously received at least two
Central Nervous System See: www.drugeruptiondata.com/drug/id/1258 chemotherapeutic regimens (prior therapy should
Dysgeusia (taste perversion) [2] have included an anthracycline and a taxane in
Vertigo (dizziness) [2] either the adjuvant or metastatic setting),
Arthralgia (2%)
ERGOCALCIFEROL unresectable or metastatic liposarcoma in
patients who have received a prior anthracycline-
Asthenia (fatigue) (2%) See: www.drugeruptiondata.com/drug/id/264 containing regimen
Class: Antineoplastic, Microtubule inhibitor
Half-life: 40 hours
Abdominal pain (2%)
Respiratory ERGOMETRINE interactions with: none known
Cough (4%) [3] Pregnancy category: N/A (No available data but
Pharyngitis (4%) Trade name: Ergometrine (Hameln) caused embryo-fetal toxicity in animal studies)
Rhinitis (4%) Indications: Management of the third stage of Important contra-indications noted in the
Upper respiratory tract infection (8%) [2] labor and in the treatment of postpartum prescribing guidelines for: nursing mothers;
hemorrhage pediatric patients
Other
Class: Amine alkaloid
Adverse effects [3]
Half-life: N/A
interactions with: halothane, sympathomimetic Peripheral edema (5–10%)
agents Rash (5–10%)
Important contra-indications noted in the Hair
prescribing guidelines for: nursing mothers Alopecia (45%) [10]
Mucosal
Cardiovascular Mucosal inflammation (9%)
Myocardial infarction [4] Stomatitis (5–10%)
Myocardial ischemia [3] Xerostomia (5–10%)
ERIBULIN See all our books at www.crcpress.com
Central Nervous System Pregnancy category: D Ocular

Anorexia (20%) [3] Important contra-indications noted in the Conjunctivitis (12%) [3]
Depression (5–10%) prescribing guidelines for: nursing mothers; Corneal perforation [2]
Dysgeusia (taste perversion) (5–10%) pediatric patients Ectropion [4]
Fever (21%) Ocular adverse effects [3]
Headache (19%) Skin Periorbital rash [2]
Insomnia (5–10%) Acne keloid [2] Trichomegaly [13]
Neurotoxicity [6] Acneform eruption [27] Other
Peripheral neuropathy (35%) [25] Dermatitis [4] Adverse effects [12]
Vertigo (dizziness) (5–10%) DRESS syndrome [2] Death [10]
Neuromuscular/Skeletal Erythema (18%) Infection (24%) [7]
Arthralgia (22%) Exanthems [3]
Asthenia (fatigue) (54%) [29] Folliculitis [9]
Hand–foot syndrome [3]
Back pain (16%)
Muscle spasm (5–10%) Papulopustular eruption [9]
ERTAPENEM
Myalgia/Myopathy (22%) Pruritus (13%) [8] Trade name: Invanz (Merck)
Pain in extremities (11%) Purpura [3] Indications: Severe resistant bacterial infections
Gastrointestinal/Hepatic Rash (75%) [112] caused by susceptible organisms
Abdominal pain (5–10%) Rosacea [2] Class: Antibiotic, carbapenem
Constipation (25%) [2] Toxicity [9] Half-life: 4 hours
Diarrhea (18%) [3] Xerosis (12%) [12] Clinically important, potentially hazardous
Dyspepsia (5–10%) Hair interactions with: probenecid
Hepatotoxicity [2] Alopecia [10] Pregnancy category: B
Nausea (35%) [9] Hair changes [4] Important contra-indications noted in the
Vomiting (18%) Hypertrichosis [4] prescribing guidelines for: the elderly; nursing
Respiratory Nails mothers
Cough (14%) Nail changes [3]
Dyspnea (16%) [2] Paronychia [11] Skin
Upper respiratory tract infection (5–10%) Mucosal Edema (3%)
Endocrine/Metabolic Mucositis [10] Erythema (<2%)
Appetite decreased [2] Stomatitis (17%) [10] Pruritus (<2%)
Hypokalemia (5–10%) Rash (23%)
Cardiovascular Wound complications [2]
Weight loss (21%) Hypertension [2]
Genitourinary Cardiovascular
Central Nervous System Phlebitis (2%)
Urinary tract infection (10%) Anorexia [9] Thrombophlebitis (2%)
Hematologic Fever [2]
Anemia (58%) [11] Central Nervous System
Neuromuscular/Skeletal Delirium [2]
Febrile neutropenia (5%) [14] Asthenia (fatigue) (52%) [31]
Leukopenia [16] Hallucinations [2]
Rhabdomyolysis [2] Seizures [7]
Lymphopenia [3]
Neutropenia (82%) [47] Gastrointestinal/Hepatic Gastrointestinal/Hepatic
Abdominal pain (11%) Nausea [2]
Ocular Cholangitis [2]
Lacrimation (increased) (5–10%) Diarrhea [67] Respiratory
Other Gastrointestinal bleeding [3] Cough (<2%)
Adverse effects [3] Hepatotoxicity [13] Genitourinary
Death [2] Nausea [16] Vaginitis (<3%)
Vomiting [8] Local
Respiratory Injection-site extravasation (2%)
ERLOTINIB Cough (33%) Other
Dyspnea [4] Death (2%)
Trade name: Tarceva (OSI) Pneumonia [2]
Indications: Non-small cell lung cancer, Pneumonitis [7]
pancreatic cancer (with gemcitabine) Pneumothorax [2]
Class: Antineoplastic, Biologic, Epidermal growth Pulmonary toxicity [15] ERYTHROMYCIN
factor receptor (EGFR) inhibitor, Tyrosine kinase Endocrine/Metabolic
inhibitor Trade names: Eryc (Warner Chilcott), PCE
ALT increased [3] (AbbVie)
Half-life: ~36 hours Appetite decreased [4]
Clinically important, potentially hazardous Indications: Various infections caused by
AST increased [3] susceptible organisms
interactions with: atazanavir, capecitabine, Dehydration [3]
carbamazepine, ciprofloxacin, clarithromycin, Class: Antibiotic, macrolide, CYP3A4 inhibitor
Hyperglycemia [3] Half-life: 1.42 hours
diclofenac, itraconazole, ketoconazole,
meloxicam, nefazodone, nelfinavir, omeprazole, Hematologic Clinically important, potentially hazardous
pantoprazole, phenobarbital, phenytoin, rifabutin, Anemia [12] interactions with: afatinib, alfentanil,
rifampin, rifapentine, ritonavir, saquinavir, St Febrile neutropenia [2] aminophylline, amisulpride, amoxicillin, ampicillin,
John’s wort, troleandomycin, voriconazole, Hemotoxicity [2] anticonvulsants, arsenic, astemizole, atorvastatin,
warfarin Leukopenia [4] avanafil, benzodiazepines, bosentan,
Neutropenia [14] bromocriptine, buprenorphine, bupropion,
Thrombocytopenia [10] carbamazepine, cilostazol, ciprofloxacin,
Litt’s Drug Eruption & Reaction Manual ESMOLOL
cisapride, clindamycin, clindamycin/tretinoin, Allergic reactions (<10%)

clopidogrel, clozapine, colchicine, cyclosporine, ESCITALOPRAM Toothache (<10%)
CYP3A inhibitors, darifenacin, dasatinib, digoxin,
dihydroergotamine, diltiazem, disopyramide, Trade name: Lexapro (Forest)
Indications: Major depressive disorders, anxiety
docetaxel, doxercalciferol, dronedarone,
enoxacin, eplerenone, ergotamine, estradiol, Class: Antidepressant, Selective serotonin ESLICARBAZEPINE
eszopiclone, everolimus, flibanserin, fluconazole, reuptake inhibitor (SSRI)
Half-life: 2732 hours Trade names: Aptiom (Sunovion), Zebinix (Eisai)
fluoxetine, fluvastatin, gatifloxacin, HMG-CoA Indications: Partial-onset seizures
reductase inhibitors, imatinib, indacaterol, Clinically important, potentially hazardous
interactions with: alcohol, bupropion, MAO Class: Antiepileptic
itraconazole, ketoconazole, levodopa, Half-life: 13–20 hours
lomefloxacin, lorazepam, lovastatin, methadone, inhibitors, methylphenidate, omeprazole,
selegiline, St John’s wort, sumatriptan, telaprevir, Clinically important, potentially hazardous
methylergonovine, methylprednisolone, interactions with: carbamazepine, digoxin,
methysergide, midazolam, mifepristone, valerian
Pregnancy category: C lamotrigine, levetiracetam, MAO inhibitors, oral
mizolastine, moxifloxacin, naldemedine, contraceptives, oxcarbazepine, phenytoin,
naloxegol, neratinib, nintedanib, nitrazepam, Important contra-indications noted in the
prescribing guidelines for: the elderly; nursing topiramate, valproic acid, warfarin
norfloxacin, ofloxacin, olaparib, oxtriphylline, Pregnancy category: C
paroxetine hydrochloride, pentamidine, mothers; pediatric patients
Warning: SUICIDALITY AND Important contra-indications noted in the
pimecrolimus, pimozide, pitavastatin, pravastatin, prescribing guidelines for: nursing mothers;
quetiapine, quinolones, ranolazine, repaglinide, ANTIDEPRESSANT DRUGS
pediatric patients
rilpivirine, rivaroxaban, roflumilast, rosuvastatin,
rupatadine, sertraline, sildenafil, silodosin, Skin
simeprevir, simvastatin, sparfloxacin, sulpiride, Diaphoresis (5%) Skin
tacrolimus, tadalafil, tamsulosin, terfenadine, Hot flashes (<10%) Peripheral edema (<2%)
tramadol, triamcinolone, triazolam, Rash (<10%) Rash (<3%) [2]
troleandomycin, vardenafil, venetoclax,
Mucosal Cardiovascular
verapamil, vilazodone, vinblastine, warfarin, Hypertension (<2%)
Oral vesiculation (<19%)
zafirlukast, zaleplon, zolpidem, zuclopenthixol Central Nervous System
Xerostomia (6%) [6]
Pregnancy category: B Balance disorder (3%)
QT prolongation [9] Depression (<3%)
prescribing guidelines for: the elderly; nursing Dysarthria (<2%)
mothers Torsades de pointes [2]
Gait instability (2%)
Central Nervous System Headache (13–15%) [12]
Skin Anxiety [2] Incoordination [3]
AGEP [2] Headache (24%) [5] Insomnia (2%)
Anaphylactoid reactions/Anaphylaxis [2] Insomnia (9–12%) [4] Somnolence (drowsiness) (11–18%) [15]
Baboon syndrome (SDRIFE) [2] Paresthesias (<10%) Tremor (2–4%)
Dermatitis (systemic) [4] Restless legs syndrome [5] Vertigo (dizziness) (20–28%) [20]
Exanthems (<5%) [4] Serotonin syndrome [5]
Somnolence (drowsiness) (6–13%) [7] Neuromuscular/Skeletal
Fixed eruption [6] Asthenia (fatigue) (4–7%) [7]
Hypersensitivity (<10%) [3] Tremor (<10%)
Vertigo (dizziness) (5%) [6] Ataxia (4–6%)
Rash [3]
Stevens-Johnson syndrome [7] Neuromuscular/Skeletal Gastrointestinal/Hepatic
Toxic epidermal necrolysis [7] Asthenia (fatigue) [4] Constipation (2%)
Urticaria [4] Myalgia/Myopathy (<10%) Diarrhea (2–4%)
Nausea (10–16%) [10]
Mucosal Gastrointestinal/Hepatic Vomiting (6–10%) [4]
Oral candidiasis (<10%) Abdominal pain [3]
Constipation [2] Respiratory
Cardiovascular Cough (<2%)
QT prolongation [5] Diarrhea [3]
Dyspepsia [2] Nasopharyngitis [2]
Torsades de pointes [8]
Nausea [9] Endocrine/Metabolic
Neuromuscular/Skeletal Vomiting [3] Hyponatremia (2%) [3]
Rhabdomyolysis [4]
Respiratory Genitourinary
Gastrointestinal/Hepatic Cough (<10%) Urinary tract infection (2%)
Abdominal pain [3] Flu-like syndrome (5%)
Diarrhea [4] Ocular
Nausea [4] Endocrine/Metabolic Diplopia (9–11%) [8]
Galactorrhea [2] Nystagmus (<2%)
Otic Hyponatremia [3] Vision blurred (5–6%) [3]
Tinnitus [3] SIADH [6] Vision impaired (<2%)
Local Weight gain [3]
Injection-site phlebitis (<10%) [2] Genitourinary
Other Ejaculatory dysfunction (9–14%) ESMOLOL
Allergic reactions (<2%) [3] Sexual dysfunction [4]
Otic Trade name: Brevibloc (Baxter)
Tinnitus (<10%) Indications: Tachyarrhythmias, tachycardia
Class: Adrenergic beta-receptor antagonist,
Ocular Antiarrhythmic class II
Glaucoma [3] Half-life: 9 minutes
Other Clinically important, potentially hazardous
Adverse effects [2] interactions with: clonidine, verapamil
ESMOLOL Over 100 updates per week on www.drugeruptiondata.com
Pregnancy category: C Skin

Important contra-indications noted in the ESTRADIOL Angioedema [2]
prescribing guidelines for: nursing mothers; Edema (>10%) [4]
pediatric patients Trade names: Alora (Watson), Climara (Bayer), Peripheral edema [2]
Divigel (Upsher-Smith), Elestrin (Azur Pharma), Pruritus (2%) [2]
Esclim (Women First), Estrace (Bristol-Myers Purpura (3%)
Skin Squibb) (Warner Chilcott), Estraderm (Novartis),
Diaphoresis (>10%) Xerosis (2%)
Estring (Pharmacia & Upjohn), Estrogel (Ascend),
Cardiovascular Evamist (KV Pharm), Fempatch (Pfizer), Gynodiol Cardiovascular
Bradycardia [5] (Barr), Innofem (Novo Nordisk), Menostar Thrombophlebitis (3%)
Hypotension [12] (Bayer), Vagifem (Novo Nordisk), Vivelle Neuromuscular/Skeletal
Local (Novartis), Vivelle-Dot (Novartis) Asthenia (fatigue) [3]
Injection-site pain (8%) Indications: Menopausal symptoms, Gastrointestinal/Hepatic
Injection-site reactions (<10%) hypoestrogenism due to hypogonadism, Diarrhea [3]
castration or primary ovarian failure, Nausea [3]
Other postmenopausal osteoporosis
Death [2] Class: Estrogen, Hormone Endocrine/Metabolic
Half-life: 1.75±2.87 hours Gynecomastia (>10%) [5]
Clinically important, potentially hazardous Mastodynia (66%)
ESOMEPRAZOLE interactions with: alcohol, amprenavir, Hematologic
anastrozole, ascorbic acid, atorvastatin, Anemia [3]
Trade name: Nexium (AstraZeneca) boceprevir, carbamazepine, chenodiol, Febrile neutropenia [2]
Indications: Gastroesophageal reflux disease clarithromycin, colesevelam, conivaptan, Leukopenia [2]
Class: Proton pump inhibitor (PPI) corticosteroids, CYP1A2 inducers, CYP3A4 Neutropenia [5]
Half-life: 1.5 hours inducers, deferasirox, delavirdine, erythromycin,
Local
Clinically important, potentially hazardous folic acid, grapefruit juice, itraconazole,
Injection-site thrombophlebitis (<10%) [3]
interactions with: benzodiazepines, ketoconazole, lopinavir, minocycline,
chlordiazepoxide, cilostazol, clonazepam, oxtriphylline, P-glycoprotein inhibitors or Other
clopidogrel, clorazepate, diazepam, digoxin, inducers, PEG-interferon, phenobarbital, Allergic reactions [2]
flurazepam, lorazepam, midazolam, oxazepam, rifampin, ritonavir, ropinirole, saxagliptin, Death [2]
posaconazole, quazepam, rifampin, rilpivirine, St somatropin, St John’s wort, telaprevir, thyroid
John’s wort, temazepam, tipranavir, voriconazole products, tipranavir, ursodiol
Pregnancy category: C Pregnancy category: X ESTROGENS
prescribing guidelines for: nursing mothers; prescribing guidelines for: the elderly; nursing See: www.drugeruptiondata.com/drug/id/269
pediatric patients mothers; pediatric patients
Note: See also separate entry for estrogens.
Warning: ENDOMETRIAL CANCER,
Skin
CARDIOVASCULAR DISORDERS, BREAST
ESZOPICLONE
DRESS syndrome [2]
Fixed eruption [2] CANCER and PROBABLE DEMENTIA
Trade names: Imovane (Sanofi-Aventis), Lunesta
Lupus erythematosus [2] (Sunovion), Zimovane (Sanofi-Aventis)
Central Nervous System Central Nervous System Indications: Insomnia
Dysgeusia (taste perversion) [3] Headache [2] Class: Hypnotic, non-benzodiazepine
Fever [2] Gastrointestinal/Hepatic Half-life: 6 hours
Headache (8–11%) [6] Nausea [3] Clinically important, potentially hazardous
Somnolence (drowsiness) [2] interactions with: alcohol, antifungals,
Respiratory cimetidine, CNS depressants, conivaptan,
Vertigo (dizziness) [3] Nasopharyngitis (10%) CYP3A4 inhibitors and inducers, dasatinib,
Neuromuscular/Skeletal Upper respiratory tract infection (6%) deferasirox, droperidol, erythromycin, ethanol,
Rhabdomyolysis [2] Endocrine/Metabolic flumazenil, ketoconazole, levomepromazine,
Gastrointestinal/Hepatic Mastodynia (7%) lorazepam, nefazodone, nelfinavir, olanzapine,
Abdominal pain [3] Genitourinary rifampin, ritonavir, St John’s wort, telithromycin,
Constipation [3] Metrorrhagia (4%) tricyclic antidepressants, valerian, voriconazole
Diarrhea [7] Pregnancy category: C
Nausea [5] Other Important contra-indications noted in the
Vomiting [4] Adverse effects [3] prescribing guidelines for: the elderly; nursing
Respiratory mothers; pediatric patients
Bronchitis (4%)
Endocrine/Metabolic
ESTRAMUSTINE Skin
Hypomagnesemia [2] Pruritus (<4%)
Trade name: Emcyt (Pfizer) Rash (<5%)
Other Indications: Prostate carcinoma
Adverse effects [6] Class: Alkylating agent, Nitrosourea Mucosal
Half-life: 20 hours Xerostomia (3–7%) [5]
Clinically important, potentially hazardous Central Nervous System
ESTAZOLAM interactions with: aldesleukin
Pregnancy category: X (not indicated for use in
Abnormal dreams (<3%)
Amnesia [3]
See: www.drugeruptiondata.com/drug/id/267 women) Anxiety (<3%)
Confusion (<3%)
Depression (<4%)
Dysgeusia (taste perversion) (8–34%) [21]
Litt’s Drug Eruption & Reaction Manual ETHACRYNIC ACID
Hallucinations (<3%) Herpes zoster [5] Genitourinary

Headache (13–21%) [8] Hidradenitis [2] Cystitis [2]
Nervousness (<5%) Leprosy [2] Urinary tract infection [2]
Neurotoxicity (<3%) Lichen planus [2] Renal
Pain (4–5%) Lichenoid eruption [3] Nephrotoxicity [2]
Somnolence (drowsiness) (8–10%) [2] Lupus erythematosus [25]
Vertigo (dizziness) [3] Lupus syndrome [3] Hematologic
Lymphoma [3] Leukopenia [2]
Gastrointestinal/Hepatic Macrophage activation syndrome [2]
Diarrhea (2–4%) Malignancies (<3%) [3]
Melanoma [2] Neutropenia [2]
Dyspepsia (2–6%) Pancytopenia [2]
Nausea (4–5%) [2] Neoplasms [2]
Nodular eruption [3] Thrombocytopenia [2]
Vomiting (<3%)
Pruritus (2–5%) [2] Otic
Endocrine/Metabolic Psoriasis [19] Otitis media [2]
Gynecomastia (<3%) Pustules [2]
Libido decreased (<3%) Ocular
Rash (3–13%) [7]
Uveitis [12]
Genitourinary Sarcoidosis [10]
Dysmenorrhea (<3%) Squamous cell carcinoma [4] Local
Urinary tract infection (<3%) Urticaria (2%) [2] Injection-site reactions (37–43%) [56]
Other Vasculitis [23] Other
Adverse effects [4] Hair Adverse effects [36]
Infection (3–10%) Alopecia [5] Allergic reactions (<3%)
Death [6]
Cardiovascular
Infection (50–81%) [43]
Atrial fibrillation [2]
ETAMSYLATE Cardiotoxicity [2]
Hypertension [2]
See: www.drugeruptiondata.com/drug/id/1374 Central Nervous System
ETELCALCETIDE *
Fever (2–3%)
Trade name: Parsabiv (Amgen)
Headache [16]
Indications: Secondary hyperparathyroidism in
ETANERCEPT Leukoencephalopathy [3]
adult patients with chronic kidney disease on
Multiple sclerosis [2]
hemodialysis
Trade names: Enbrel (Amgen), Erelzi (Sandoz) Neurotoxicity [4]
Class: Calcimimetic
Indications: Rheumatoid arthritis, polyarticular Paresthesias [2]
juvenile idiopathic arthritis in patients aged 2 years Peripheral neuropathy [2]
or older, psoriatic arthritis, ankylosing spondylitis, Vertigo (dizziness) [2]
plaque psoriasis Neuromuscular/Skeletal Pregnancy category: N/A (No data available)
Class: Cytokine inhibitor, Disease-modifying Asthenia (fatigue) [7] Important contra-indications noted in the
antirheumatic drug (DMARD), TNF inhibitor Back pain [2] prescribing guidelines for: nursing mothers;
Half-life: 4–13 days Myalgia/Myopathy [2] pediatric patients
Clinically important, potentially hazardous Myasthenia gravis [3]
interactions with: abatacept, anakinra,
cyclophosphamide, live vaccines Gastrointestinal/Hepatic Skin
Pregnancy category: B Abdominal pain [3] Facial edema (<4%)
Important contra-indications noted in the Crohn’s disease [4] Hypersensitivity (4%)
prescribing guidelines for: the elderly; nursing Diarrhea (8–16%) [4] Pruritus (<4%)
mothers; pediatric patients Gastroenteritis [3] Urticaria (<4%)
Note: TNF inhibitors should be used in patients Hepatotoxicity [4]
Cardiovascular
with heart failure only after consideration of other Inflammatory bowel disease [2]
Cardiac failure (2%)
treatment options. Contra-indicated in patients Nausea [5]
with sepsis. TNF inhibitors are contra-indicated in Respiratory Headache (8%)
patients with a personal or family history of Asthma [2]
Paresthesias (6%)
multiple sclerosis or demyelinating disease. TNF Bronchitis [4]
inhibitors should not be administered to patients Cough [4] Neuromuscular/Skeletal
with moderate to severe heart failure (New York Flu-like syndrome [3] Muscle spasm (12%)
Heart Association Functional Class III/IV). Laryngitis [2] Myalgia/Myopathy (2%)
Warning: SERIOUS INFECTIONS AND Nasopharyngitis [3] Gastrointestinal/Hepatic
MALIGNANCIES Pharyngitis [4] Diarrhea (11%)
Pneumonia [5] Nausea (11%) [3]
Skin Pneumonitis [2] Vomiting (9%) [3]
Abscess [2] Pulmonary toxicity [4]
Endocrine/Metabolic
Anaphylactoid reactions/Anaphylaxis [2] Rhinitis [4]
Hyperkalemia (4%)
Carcinoma [2] Sinusitis [5]
Hypocalcemia (7–64%) [3]
Cellulitis [2] Tuberculosis [2]
Dermatitis [3] Upper respiratory tract infection (38–65%)
Dermatomyositis [4] [10]
Exanthems [2] Endocrine/Metabolic ETHACRYNIC ACID
Granulomas [2] ALT increased [3]
Granulomatous reaction [5] Hypertriglyceridemia [2]
Henoch–Schönlein purpura [3] Thyroiditis [2]
ETHAMBUTOL See all our books at www.crcpress.com
phenobarbital, phenytoin, primidone, risperidone, adverse events, which can be fatal. This risk may
ETHAMBUTOL SSRIs, St John’s wort, tricyclic antidepressants, increase with duration of use.
valproic acid, zuclopenthixol
Trade name: Myambutol (Stat Trade) Pregnancy category: C
Indications: Tuberculosis Skin
Important contra-indications noted in the Exanthems [2]
Class: Antimycobacterial prescribing guidelines for: nursing mothers
Half-life: 34 hours Facial edema [2]
Note: Cases of birth defects have been reported Fixed eruption [2]
Clinically important, potentially hazardous with ethosuximide.
interactions with: cortisone, zinc Pruritus (<10%) [7]
Pregnancy category: C Rash (>10%) [5]
Important contra-indications noted in the Skin Vasculitis [2]
prescribing guidelines for: nursing mothers; Exanthems (<5%) [2] Gastrointestinal/Hepatic
pediatric patients Lupus erythematosus (>10%) [22] Abdominal pain [2]
Raynaud’s phenomenon [3] Constipation [2]
Stevens-Johnson syndrome (>10%) Dyspepsia [3]
Skin Urticaria (<5%)
Bullous dermatitis [2] Nausea [2]
Dermatitis [2] Hematologic Other
DRESS syndrome [5] Agranulocytosis [2] Adverse effects [2]
Erythema multiforme [2] Other
Exanthems (<5%) [4] Side effects (3%)
Lichenoid eruption [2]
ETOMIDATE
Pruritus [4]
ETHOTOIN See: www.drugeruptiondata.com/drug/id/1399
Rash [2] See: www.drugeruptiondata.com/drug/id/277

Urticaria [2] ETOPOSIDE
Renal
Nephrotoxicity [2]
ETHOXZOLAMIDE Trade name: VePesid (Bristol-Myers Squibb)
Indications: Lymphomas, carcinomas
Ocular See: www.drugeruptiondata.com/drug/id/1951 Class: Topoisomerase 2 inhibitor
Amblyopia [2] Half-life: 4–11 hours
Ocular toxicity [9] Clinically important, potentially hazardous
Optic neuritis [4]
Optic neuropathy [9]
ETIDRONATE interactions with: aldesleukin, atovaquone,
atovaquone/proguanil, cyclosporine, gadobenate,
Vision impaired [2] Trade name: Didronel (Procter & Gamble) prednisolone, St John’s wort
Other Indications: Paget’s disease, osteoporosis Pregnancy category: D
Adverse effects [4] Class: Bisphosphonate Important contra-indications noted in the
Half-life: 6 hours prescribing guidelines for: the elderly; nursing
Clinically important, potentially hazardous mothers; pediatric patients
interactions with: ferrous sulfate
ETHANOLAMINE Pregnancy category: C Skin
See: www.drugeruptiondata.com/drug/id/273 Important contra-indications noted in the Anaphylactoid reactions/Anaphylaxis (<2%)
prescribing guidelines for: nursing mothers; [3]
pediatric patients Erythema [3]
Exanthems [4]
ETHCHLORVYNOL Neuromuscular/Skeletal Hand–foot syndrome [4]
Fractures [6] Hypersensitivity [9]
See: www.drugeruptiondata.com/drug/id/274 Pigmentation [2]
Osteomalacia [3]
Pseudogout [2] Radiation recall dermatitis [3]
Skeletal toxicity [2] Rash [2]
ETHIONAMIDE Gastrointestinal/Hepatic
Toxicity [2]
See: www.drugeruptiondata.com/drug/id/275 Esophagitis [2]
Hair
Alopecia (866%) [8]
ETODOLAC Mucosal
ETHOSUXIMIDE Mucositis (>10%)
Trade name: Lodine (Wyeth) Oral lesions (<5%) [2]
Trade name: Zarontin (Pfizer) Stomatitis (<10%) [2]
Indications: Absence (petit mal) seizures Indications: Pain
Class: Antiepileptic, succinimide Class: COX-2 inhibitor, Non-steroidal anti- Cardiovascular
Half-life: 5060 hours inflammatory (NSAID) Flushing [3]
Clinically important, potentially hazardous Half-life: 7 hours Central Nervous System
interactions with: antipsychotics, Clinically important, potentially hazardous Anorexia [2]
carbamazepine, chloroquine, cobicistat/ interactions with: aspirin, methotrexate Leukoencephalopathy [2]
elvitegravir/emtricitabine/tenofovir alafenamide, Pregnancy category: C Neurotoxicity [3]
cobicistat/elvitegravir/emtricitabine/tenofovir Important contra-indications noted in the
prescribing guidelines for: the elderly; nursing Neuromuscular/Skeletal
disoproxil, hydroxychloroquine, isoniazid, Asthenia (fatigue) [2]
levomepromazine, lisdexamfetamine, MAO mothers; pediatric patients
inhibitors, mefloquine, nevirapine, orlistat, Note: NSAIDs may cause an increased risk of Gastrointestinal/Hepatic
serious cardiovascular and gastrointestinal Diarrhea [2]
Litt’s Drug Eruption & Reaction Manual EVEROLIMUS
Hepatotoxicity [2] Amnesia (<2%)

Nausea [5] Anorexia (<2%) EVEROLIMUS
Vomiting [7] Anxiety (<2%)
Confusion (<2%) Trade names: Afinitor (Novartis), Certican
Respiratory (Novartis), Zortress (Novartis)
Pulmonary toxicity [2] Disorientation (<2%)
Headache (3%) [3] Indications: Prophylaxis of organ rejection in
Endocrine/Metabolic Hypersomnia (<2%) adults following kidney or liver transplant,
Hyponatremia [2] Hypoesthesia (<2%) advanced renal cell carcinoma, neuroendocrine
Renal Insomnia (<2%) tumors of pancreatic, gastrointestinal or lung
Nephrotoxicity [3] Nervousness (<2%) origin, breast cancer in post-menopausal women
Neurotoxicity [3] with advanced hormone-receptor positive,
Hematologic HER2-negative type cancer, renal
Anemia [5] Nightmares (<2%)
Paresthesias (<2%) angiomyolipoma and tuberous sclerosis complex,
Febrile neutropenia [5] subependymal giant cell astrocytoma associated
Leukopenia [3] Peripheral neuropathy (3%)
Seizures (<2%) with tuberous sclerosis
Neutropenia [11] Class: Antineoplastic, Immunosuppressant,
Thrombocytopenia [9] Sleep related disorder (<2%)
Somnolence (drowsiness) (<2%) mTOR inhibitor
Other Syncope (<2%) Half-life: ~30 hours
Adverse effects [3] Tremor (<2%) Clinically important, potentially hazardous
Allergic reactions (<2%) Vertigo (dizziness) (<2%) interactions with: aprepitant, atazanavir,
Death [2] atorvastatin, benazepril, captopril, clarithromycin,
Infection [4] Neuromuscular/Skeletal clozapine, conivaptan, cyclosporine, darunavir,
Asthenia (fatigue) (3%) delavirdine, digoxin, efavirenz, enalapril,
Gastrointestinal/Hepatic erythromycin, grapefruit juice, indinavir,
Abdominal distension (<2%)
ETORICOXIB Abdominal pain (3%)
itraconazole, ketoconazole, lapatinib, lisinopril,
live vaccines, nelfinavir, oxcarbazepine, phenytoin,
See: www.drugeruptiondata.com/drug/id/1235 Constipation (<2%) posaconazole, quinapril, ramipril, ribociclib,
Diarrhea [3] rifampin, rifapentine, ritonavir, saquinavir, St
Flatulence (<2%) John’s wort, telithromycin, venetoclax, verapamil,
Gastritis (<2%) voriconazole
ETRAVIRINE Gastroesophageal reflux (<2%) Pregnancy category: D
Hematemesis (<2%) Important contra-indications noted in the
Trade name: Intelence (Tibotec) Hepatic failure (<2%) prescribing guidelines for: nursing mothers;
Indications: HIV infection Hepatomegaly (<2%) pediatric patients
Class: Non-nucleoside reverse transcriptase Hepatotoxicity [2] Warning: In immunosuppression therapy:
inhibitor Nausea [4] MALIGNANCIES AND SERIOUS INFECTIONS,
Half-life: 41 hours Pancreatitis (<2%) KIDNEY GRAFT THROMBOSIS;
Clinically important, potentially hazardous Retching (<2%) NEPHROTOXICITY
interactions with: atazanavir, atorvastatin, In heart transplantation: MORTALITY
carbamazepine, clarithromycin, clopidogrel, Respiratory
darunavir, delavirdine, digoxin, efavirenz, Bronchospasm (<2%)
fosamprenavir, indinavir, maraviroc, nelfinavir, Dyspnea (<2%) Skin
neratinib, nevirapine, non-nucleoside reverse Endocrine/Metabolic Acneform eruption (3–25%) [5]
transcriptase inhibitors, olaparib, palbociclib, Diabetes mellitus (<2%) Angioedema [4]
phenobarbital, phenytoin, rifabutin, rifampin, Gynecomastia (<2%) Cellulitis (21%)
rifapentine, rilpivirine, ritonavir, sildenafil, Contact dermatitis (14%)
Renal
simeprevir, St John’s wort, tadalafil, telithromycin, Edema (39%) [4]
Renal failure (<2%)
tipranavir, vardenafil, venetoclax, voriconazole Erythema (4%)
Pregnancy category: B Hematologic Excoriations (14%)
Important contra-indications noted in the Dyslipidemia (<2%) Hand–foot syndrome (5%) [9]
prescribing guidelines for: nursing mothers; Hemolytic anemia (<2%) Hypersensitivity [2]
pediatric patients Ocular Lymphedema [2]
Vision blurred (<2%) Peripheral edema (4–39%) [8]
Pityriasis rosea (4%)
Skin Other Pruritus (14–21%) [5]
Facial edema (<2%) Adverse effects [6] Rash (18–59%) [47]
Hyperhidrosis (<2%)
Tinea (18%)
Lipohypertrophy (<2%)
Toxicity [9]
Prurigo (<2%)
Xerosis (13–18%)
Rash (9%) [17]
Xerosis (<2%) Nails
Nail disorder (4–22%) [2]
Mucosal
Stomatitis (<2%) Mucosal
Xerostomia (<2%) Aphthous stomatitis [4]
Epistaxis (nosebleed) (18–22%) [3]
Cardiovascular Mucosal inflammation (19%) [3]
Angina (<2%)
Mucositis [17]
Atrial fibrillation (<2%)
Nasal congestion (14%)
Hypertension (3%)
Oral ulceration [4]
Myocardial infarction (<2%)
Oropharyngeal pain (11%)
Central Nervous System Rhinorrhea (3%)
Abnormal dreams (<2%) Stomatitis (44–86%) [70]
EVEROLIMUS Over 100 updates per week on www.drugeruptiondata.com
Xerostomia (8–11%) Weight loss (9–28%) [3] Muscle spasm [6]

Cardiovascular Genitourinary Myalgia/Myopathy (3%) [10]
Chest pain (5%) Urinary tract infection (15%) Pain in extremities [5]
Hypertension (4–13%) [14] Renal Gastrointestinal/Hepatic
Tachycardia (3%) Nephrotoxicity [5] Diarrhea (3%) [5]
Central Nervous System Proteinuria (7%) [15] Gastroenteritis (2%) [2]
Anorexia (25%) [12] Renal failure (3%) [3] Hepatotoxicity [5]
Anxiety (7%) Nausea [4]
Hematologic
Chills (4%) Anemia [35] Respiratory
Dysgeusia (taste perversion) (10–19%) [2] Febrile neutropenia [5] Cough (<4%) [3]
Fever (20–32%) [7] Hemoglobin decreased (86–92%) [2] Influenza (<6%) [9]
Headache (18–30%) [4] Hemolytic uremic syndrome [2] Nasopharyngitis (4–10%) [13]
Insomnia (9%) Hemorrhage (3%) [3] Pharyngitis [2]
Migraine (30%) Hemotoxicity [5] Sinusitis (3%) [2]
Pain [2] Immunosupression [2] Upper respiratory tract infection (2–6%)
Peripheral neuropathy [2] Leukopenia [4] [10]
Seizures (29%) Lymphopenia [8] Endocrine/Metabolic
Somnolence (drowsiness) (7%) Neutropenia [17] Creatine phosphokinase increased [9]
Vertigo (dizziness) (7–14%) Platelets decreased (23–45%) Genitourinary
Neuromuscular/Skeletal Sepsis [2] Urinary tract infection (<4%)
Arthralgia (15%) Thrombocytopenia [20]
Asthenia (fatigue) (7–45%) [60] Local
Otic Injection-site bruising [4]
Back pain (15%) Otitis media (36%)
Jaw pain (3%) Injection-site edema [2]
Muscle spasm (10%) Ocular Injection-site erythema [3]
Pain in extremities (10–14%) Conjunctivitis (2%) Injection-site pain [7]
Eyelid edema (4%) [2] Injection-site reactions (3–5%) [9]
Gastrointestinal/Hepatic Ocular hyperemia (4%)
Abdominal pain (9–36%) [4] Other
Constipation (11–14%) Other Adverse effects [6]
Diarrhea (25–50%) [34] Adverse effects [29] Allergic reactions (5%)
Dysphagia (4%) Death [8]
Gastritis (7%) Infection (18%) [29]
Gastroenteritis (18%) Side effects [2] EXEMESTANE
Gastrointestinal bleeding [3]
Hemorrhoids (5%) Trade name: Aromasin (Pfizer)
Hepatotoxicity [7] EVOLOCUMAB Indications: Advanced breast cancer
Nausea (26–32%) [10] Class: Aromatase inhibitor
Pancreatitis [2] Trade name: Repatha (Amgen) Half-life: 24 hours
Vomiting (20–29%) [3] Indications: Heterozygous or homozygous Clinically important, potentially hazardous
Respiratory familial hypercholesterolemia where additional interactions with: efavirenz, oxcarbazepine,
Cough (21–30%) [6] lowering of low density lipoprotein cholesterol is rifapentine
Dyspnea (20–24%) [7] required Pregnancy category: X
Nasopharyngitis (25%) Class: Monoclonal antibody, Proprotein Important contra-indications noted in the
Pharyngitis (11%) convertase subtilisin kexin type 9 (PCSK9) prescribing guidelines for: nursing mothers;
Pharyngolaryngeal pain (4%) inhibitor pediatric patients
Pleural effusion (7%) Half-life: 11–17 days
Pneumonia [10] Clinically important, potentially hazardous Skin
Pneumonitis (14–17%) [41] interactions with: none known Diaphoresis (612%) [2]
Pulmonary toxicity [10] Pregnancy category: N/A (No data available but Edema (7%)
Rhinitis (25%) likely to cross the placenta in second and third Hot flashes (30%) [7]
Sinusitis (39%) trimester) Lymphedema (25%)
Upper respiratory tract infection (25–82%) Important contra-indications noted in the Peripheral edema (9%) [2]
[2] prescribing guidelines for: pediatric patients Pruritus (25%)
Endocrine/Metabolic Radiation recall dermatitis [2]
ALT increased (21–48%) [4] Mucosal Rash (25%) [6]
Appetite decreased (30%) [5] Nasal congestion [2] Hair
AST increased (25–56%) [3] Oropharyngeal pain [2] Alopecia (25%)
Diabetes mellitus (2–10%) [2] Cardiovascular Mucosal
GGT increased [2] Hypertension (2%) Stomatitis [7]
Hypercholesterolemia [7] Central Nervous System
Hyperglycemia [32] Central Nervous System
Headache (4%) [10] Dysgeusia (taste perversion) [2]
Hyperlipidemia [8] Neurotoxicity [2]
Hypertriglyceridemia [2] Headache [3]
Vertigo (dizziness) (3%) Insomnia [2]
Hypokalemia [4]
Hypomagnesemia [2] Neuromuscular/Skeletal Paresthesias (25%)
Hyponatremia [3] Arthralgia (2%) [8] Tumor pain (30%)
Hypophosphatemia [5] Asthenia (fatigue) [3] Neuromuscular/Skeletal
Hypothyroidism [2] Back pain (2–6%) [10] Arthralgia [4]
Serum creatinine increased (19–50%) [4] Bone or joint pain (3%) [3] Asthenia (fatigue) [6]
Litt’s Drug Eruption & Reaction Manual EZOGABINE
Back pain [2] Endocrine/Metabolic Local

Bone or joint pain [2] Appetite decreased (<10%) [3] Injection-site erythema [2]
Myalgia/Myopathy [2] Hypoglycemia (>5%) [4] Injection-site reactions [5]
Gastrointestinal/Hepatic Genitourinary Other
Diarrhea [4] Urinary tract infection [2] Adverse effects [6]
Respiratory Renal
Pneumonitis [5] Nephrotoxicity [2]
Endocrine/Metabolic Renal failure [3] EZOGABINE
Hyperglycemia [4] Local
Injection-site erythema (5–7%) Synonym: retigabine
Hematologic Trade names: Potiga (GSK), Trobalt (GSK)
Anemia [2] Injection-site nodules (~10%) [4]
Injection-site pruritus (5–6%) [2] Indications: Epilepsy
Other Injection-site reactions [7] Class: Anticonvulsant, Potassium channel opener
Adverse effects [2] Half-life: 7–11 hours
Adverse effects [10] interactions with: alcohol, carbamazepine,
Cancer [2]
EXENATIDE digoxin, phenytoin
Trade names: Bydureon (Amylin), Byetta Important contra-indications noted in the
(Amylin) EZETIMIBE prescribing guidelines for: the elderly; nursing
Indications: Type II diabetes mellitus mothers; pediatric patients
Class: Glucagon-like peptide-1 (GLP-1) receptor Trade names: Ezetrol (Merck), Liptruzet (Merck Warning: RETINAL ABNORMALITIES AND
agonist, Incretin mimetic, Insulin secretagogue Sharpe & Dohme), Vytorin (MSD), Zetia (Merck) POTENTIAL VISION LOSS
Half-life: 2.4 hours Indications: Hypercholesterolemia
Clinically important, potentially hazardous Class: Cholesterol inhibitor Skin
interactions with: acetaminophen, alcohol, Half-life: 22 hours Hyperhidrosis (<2%)
antibiotics, corticosteroids, lovastatin, oral Clinically important, potentially hazardous Peripheral edema (<2%)
contraceptives, pegvisomant, prandial insulin, interactions with: cholestyramine, cyclosporine, Pigmentation [2]
somatropin, sulfonylureas, thiazide diuretics, fenofibrate, gemfibrozil, HMG-CoA reductase
inhibitors, ritonavir Mucosal
vitamin K antagonists, warfarin Mucosal membrane pigmentation [4]
Pregnancy category: C Pregnancy category: C (Pregnancy category is
X when combined with a statin.) Xerostomia (<2%)
prescribing guidelines for: nursing mothers; Important contra-indications noted in the Central Nervous System
pediatric patients prescribing guidelines for: nursing mothers Amnesia (2%)
Note: Risk of thyroid C-cell tumors with Note: Liptruzet is ezetimibe and atorvastatin; Anxiety (3%)
exenatide extended release formulations. vytorin is ezetimibe and simvastatin. Aphasia (4%)
Bydureon is contra-indicated in patients with a Balance disorder (4%)
personal or family history of medullary thyroid Skin Confusion (9%) [6]
carcinoma or in patients with multiple endocrine Rash [3] Disorientation (2%)
neoplasia syndrome Type 2. Dysarthria (4%) [3]
Central Nervous System Dysphasia (2%)
Headache [5] Gait instability (4%)
Skin Vertigo (dizziness) [4] Hallucinations (<2%)
Hyperhidrosis (<10%) Neuromuscular/Skeletal Headache [6]
Urticaria [2] Arthralgia (4%) [3] Hypokinesia (<2%)
Cardiovascular Asthenia (fatigue) [2] Impaired concentration (6%)
Cardiotoxicity [2] Back pain (4%) [4] Incoordination (7%)
Central Nervous System Bone or joint pain [4] Memory loss (6%)
Chills (<2%) Muscle spasm [3] Neurotoxicity [3]
Headache (<10%) [8] Myalgia/Myopathy (5%) [16] Paresthesias (3%)
Vertigo (dizziness) (<10%) [3] Pain in extremities [2] Somnolence (drowsiness) (22%) [14]
Gastrointestinal/Hepatic Speech disorder [3]
Neuromuscular/Skeletal Tremor (8%) [3]
Asthenia (fatigue) (<10%) Abdominal pain (2%)
Diarrhea [4] Vertigo (dizziness) (31%) [14]
Gastrointestinal/Hepatic Hepatotoxicity [6] Neuromuscular/Skeletal
Abdominal distension (<10%) Nausea [4] Asthenia (fatigue) (20%) [11]
Abdominal pain (<10%) [2] Pancreatitis [3] Ataxia [3]
Constipation (>5%) Myoclonus (<2%)
Diarrhea (<11%) [18] Respiratory
Dyspepsia (<10%) Cough (2%) Gastrointestinal/Hepatic
Flatulence (2%) Influenza [3] Constipation (3%)
Gastroenteritis (<10%) Nasopharyngitis [5] Dyspepsia (2%)
Gastroesophageal reflux (3%) Upper respiratory tract infection [2] Dysphagia (<2%)
Nausea (<11%) [43] Endocrine/Metabolic Nausea (7%) [5]
Pancreatitis [10] Creatine phosphokinase increased [8] Respiratory
Vomiting (~10%) [25] Genitourinary Influenza (3%)
Respiratory Urinary tract infection [2] Endocrine/Metabolic
Nasopharyngitis [2] Hematologic Appetite increased (<2%)
Thrombocytopenia [2] Weight gain (dose related) (3%)
EZOGABINE See all our books at www.crcpress.com
Genitourinary Renal Vision blurred (5%) [2]

Dysuria (2%) Chromaturia (2%) Other
Hematuria (2%) Ocular Adverse effects [2]
Urinary hesitancy (2%) Diplopia (7%) [2]
Urinary retention (<2%) [6] Ocular pigmentation [4]
Litt’s Drug Eruption & Reaction Manual FENOPROFEN

FACTOR VIII - VON Confusion [2] FELBAMATE
Delirium [3]
WILLEBRAND FACTOR Fever [2] See: www.drugeruptiondata.com/drug/id/283
Headache (5%) [4]
Neurotoxicity [2]
Somnolence (drowsiness) [2] FELBINAC
FAMCICLOVIR Arthralgia [2] See: www.drugeruptiondata.com/drug/id/1407
Trade name: Famvir (Novartis)

Back pain [2]
Indications: Acute herpes zoster, recurrent Gastrointestinal/Hepatic
genital herpes Abdominal pain [2] FELODIPINE
Class: Antiviral, Guanine nucleoside analog Diarrhea (2%) [3]
Dyspepsia [3] See: www.drugeruptiondata.com/drug/id/284
Half-life: 23 hours
Clinically important, potentially hazardous Gastroesophageal reflux [2]
interactions with: none known Nausea [4]
Pregnancy category: B Vomiting [4] FENBUFEN
Important contra-indications noted in the Respiratory
prescribing guidelines for: nursing mothers; Influenza [2] See: www.drugeruptiondata.com/drug/id/1143
pediatric patients Sinusitis [2]
Skin Endocrine/Metabolic FENOFIBRATE
Pruritus (4%) Hypomagnesemia [2]
Rash (<4%) Hypophosphatemia [2] Trade name: Tricor (AbbVie)
Vasculitis [3] Indications: Hyperlipidemia
Genitourinary Class: Fibrate, Lipid regulator
Central Nervous System Urinary tract infection [2] Half-life: 20 hours
Paresthesias (<3%)
Eosinophilia [2] interactions with: atorvastatin, colchicine,
Neuromuscular/Skeletal Thrombocytopenia [2] dicumarol, ezetimibe, lovastatin, nicotinic acid,
Asthenia (fatigue) (<5%) rosuvastatin, statins, warfarin
Gastrointestinal/Hepatic Pregnancy category: C
Abdominal pain (<8%) [2]
Diarrhea (2–9%)
FEBUXOSTAT prescribing guidelines for: the elderly; nursing
Flatulence (<5%) mothers; pediatric patients
Trade name: Uloric (Takeda)
Nausea (2–13%) [3] Indications: Hyperuricemia in gout
Vomiting (<5%) [2] Class: Xanthine oxidase inhibitor Skin
Genitourinary Half-life: 5–8 hours Photosensitivity [11]
Dysmenorrhea (<8%) Clinically important, potentially hazardous Phototoxicity [2]
interactions with: aminophylline, azathioprine, Pruritus (4%)
Other Rash (28%) [3]
didanosine, mercaptopurine, oxtriphylline,
Adverse effects [4]
theophylline Neuromuscular/Skeletal
Pregnancy category: C Myalgia/Myopathy [11]
Rhabdomyolysis [18]
FAMOTIDINE Skin Gastrointestinal/Hepatic
Trade names: Duexis (Horizon), Pepcid
Rash (2%) [7] Hepatotoxicity [15]
(Valeant) Cardiovascular Pancreatitis [3]
Indications: Duodenal ulcer, gastric ulcer, Cardiotoxicity [2] Endocrine/Metabolic
gastroesophageal reflux disease Central Nervous System Gynecomastia [2]
Class: Histamine H2 receptor antagonist Headache [5] Renal
Half-life: 2.53.5 hours Vertigo (dizziness) [5] Nephrotoxicity [3]
Neuromuscular/Skeletal Renal failure [2]
interactions with: atazanavir, cefditoren,
dasatinib, delavirdine, rilpivirine, thalidomide Arthralgia [5] Other
Pregnancy category: B Bone or joint pain [2] Adverse effects (<10%)
Important contra-indications noted in the Gouty tophi (flare) [3]
prescribing guidelines for: nursing mothers Joint disorder [2]
Note: Duexis is famotidine and ibuprofen. Gastrointestinal/Hepatic
Diarrhea [9]
FENOLDOPAM
Skin Hepatotoxicity (5%) [13] See: www.drugeruptiondata.com/drug/id/994
Dermatitis [3] Nausea [7]
Peripheral edema [2] Vomiting [2]
Pruritus [2] Respiratory
FENOPROFEN
Rash [3]
Urticaria [3] Other See: www.drugeruptiondata.com/drug/id/287
Vasculitis [2] Adverse effects [7]
Cardiovascular
Hypertension [3]
FENTANYL Over 100 updates per week on www.drugeruptiondata.com
Respiratory Respiratory
FENTANYL Cough [15] Dyspnea [3]
Respiratory depression [7] Local
Trade names: Actiq (Cephalon), Duragesic
(Janssen) Ocular Injection-site pain [3]
Indications: Chronic pain Miosis (>10%) Other
Class: Analgesic, opioid, Anesthetic Local Adverse effects [2]
Half-life: ~7 hours Application-site erythema [2]
Clinically important, potentially hazardous Other
interactions with: amiodarone, amprenavir,
aprepitant, atazanavir, ceritinib, cimetidine,
Adverse effects [7] FESOTERODINE
Death [7]
conivaptan, crizotinib, darunavir, dasatinib, Trade name: Toviaz (Pfizer)
delavirdine, efavirenz, eluxadoline, enzalutamide, Indications: Overactive bladder syndrome,
indinavir, itraconazole, ketoconazole, lapatinib,
lopinavir, mifepristone, nelfinavir, nevirapine, FERRIC GLUCONATE urinary incontinence, urgency and frequency
Class: Antimuscarinic, Muscarinic antagonist
nifedipine, osimertinib, ranitidine, ribociclib, Half-life: 7 hours; 4 hours (oral)
rifapentine, ritonavir, saquinavir, telithromycin, See: www.drugeruptiondata.com/drug/id/2817
voriconazole interactions with: alcohol, amantadine,
Pregnancy category: C anticholinergics, antidepressants, antimuscarinics,
Important contra-indications noted in the FERROUS SULFATE atazanavir, botulinum toxin (A & B),
prescribing guidelines for: nursing mothers; carbamazepine, cinacalcet, clarithromycin,
pediatric patients See: www.drugeruptiondata.com/drug/id/2677 conivaptan, CYP2D6 inhibitors, CYP3A4
Note: Contra-indicated in opioid non-tolerant inhibitors, CYP3AF inhibitors, darunavir,
patients, and for the management of acute or dasatinib, deferasirox, delavirdine, duloxetine,
postoperative pain including headache/migraines
and dental pain.
FERUMOXSIL indinavir, itraconazole, ketoconazole, nefazodone,
nelfinavir, PEG-interferon, phenobarbital,
Warning: ADDICTION, ABUSE, and MISUSE; See: www.drugeruptiondata.com/drug/id/2235 phenytoin, pramlintide, rifampin, ritonavir,
LIFE-THREATENING RESPIRATORY saquinavir, secretin, St John’s wort, telithromycin,
DEPRESSION; ACCIDENTAL EXPOSURE; terbinafine, tipranavir, tocilizumab, voriconazole
NEONATAL OPIOID WITHDRAWAL
SYNDROME; CYTOCHROME P450 3A4 FERUMOXYTOL Pregnancy category: C
INTERACTION prescribing guidelines for: nursing mothers;
EXPOSURE TO HEAT (for topical patches) Trade name: Feraheme (AMG Pharma)
Indications: Iron deficiency anemia in adults with pediatric patients
chronic kidney disease Note: Contra-indicated in patients with urinary
Skin Class: Iron supplement retention, gastric retention, or uncontrolled
Anaphylactoid reactions/Anaphylaxis [6] Half-life: 15 hours narrow-angle glaucoma.
Diaphoresis (>10%) [2] Clinically important, potentially hazardous
Edema (>10%) interactions with: none known Mucosal
Erythema (at application site) [3] Pregnancy category: C Xerostomia (19–35%) [28]
Pruritus (344%) [30] Important contra-indications noted in the
Rash [3]
prescribing guidelines for: the elderly; nursing Headache [3]
Mucosal mothers; pediatric patients
Xerostomia (>10%) [3] Note: May cause hypersensitivity reactions, Neuromuscular/Skeletal
hypotension and iron overload. Feraheme may Back pain (2%)
Cardiovascular
Bradycardia (>10%) [3]
transiently affect magnetic resonance (MRI) Gastrointestinal/Hepatic
imaging for up to 3 months following dosage. Constipation (4–6%) [16]
Flushing (310%)
Contra-indicated in patients with evidence of iron Diarrhea (<10%)
Hypotension [8]
overload or anemia not caused by iron deficiency. Dyspepsia (<2%) [2]
Tachycardia [2]
Nausea (<2%) [2]
Skin Respiratory
Agitation [2]
Anaphylactoid reactions/Anaphylaxis [3] Upper respiratory tract infection (2–3%)
Anorexia [2]
Hypersensitivity [3] Genitourinary
Confusion (>10%)
Pruritus [5] Dysuria (<2%)
Delirium [2]
Rash [2] Urinary retention [2]
Depression (>10%)
Urticaria [2] Urinary tract infection (3–4%) [3]
Hallucinations [2]
Headache (>10%) Cardiovascular Ocular
Neuroleptic malignant syndrome [2] Hypotension (3%) [3] Vision blurred [2]
Sedation [2] Central Nervous System Xerophthalmia (<4%) [2]
Serotonin syndrome [4] Headache [6]
Somnolence (drowsiness) [13] Other
Vertigo (dizziness) (3%) [3] Adverse effects [3]
Neuromuscular/Skeletal Asthenia (fatigue) [2]
Asthenia (fatigue) (>10%) [2] Back pain [2]
Myoclonus [3]
Gastrointestinal/Hepatic Abdominal pain [2]
Constipation (>10%) [11] Nausea (3%) [6]
Nausea (>10%) [31] Vomiting [2]
Vomiting (>10%) [21]
Litt’s Drug Eruption & Reaction Manual FINGOLIMOD
Pregnancy category: N/A (Contra-indicated in Skin

FEXOFENADINE women) Basal cell carcinoma [4]
Important contra-indications noted in the Eczema (3%)
Trade name: Allegra (Sanofi-Aventis) prescribing guidelines for: nursing mothers; Herpes (9%) [6]
Indications: Allergic rhinitis, pruritus, urticaria pediatric patients Herpes simplex [3]
Class: Histamine H1 receptor antagonist Herpes zoster [3]
Half-life: 14.4 hours Kaposi’s sarcoma [2]
Folliculitis [2] Lymphoma [2]
interactions with: neratinib, St John’s wort Melanoma [2]
Pregnancy category: C Rash [3]
Urticaria [2] Neoplasms [2]
Important contra-indications noted in the Pruritus (3%)
prescribing guidelines for: the elderly; nursing Xerosis [2]
Skin cancer [3]
mothers; pediatric patients Hair Tinea (4%)
Hirsutism [3] Varicella zoster [5]
Skin Cardiovascular Hair
Urticaria [3] Postural hypotension [2] Alopecia (4%)
Central Nervous System Central Nervous System Cardiovascular
Headache (5–11%) [2] Depression [6] Asystole [2]
Headache [2] Atrial fibrillation [2]
Vertigo (dizziness) (7%) [3] Atrioventricular block [19]
FIDAXOMICIN Neuromuscular/Skeletal Bradycardia (4%) [23]
Asthenia (fatigue) (5%) [2] Cardiac failure [2]
See: www.drugeruptiondata.com/drug/id/2537 Myalgia/Myopathy (severe) [2] Cardiotoxicity [3]
Endocrine/Metabolic Hypertension (6%) [9]
Gynecomastia (<2%) [15] Central Nervous System
FINAFLOXACIN Libido decreased (2–10%) [8] Depression (8%)
Mastodynia (<2%) Encephalopathy [2]
Trade name: Xtoro (Alcon) Menstrual irregularities [2] Headache (25%) [10]
Indications: Acute otitis externa caused by Genitourinary Leukoencephalopathy [6]
susceptible strains of Pseudomonas aeruginosa and Ejaculatory dysfunction [9] Migraine (5%)
Staphylococcus aureus Erectile dysfunction [7] Paresthesias (5%)
Class: Antibiotic, fluoroquinolone Impotence (5–19%) Vertigo (dizziness) (7%)
Half-life: N/A Sexual dysfunction [6] Neuromuscular/Skeletal
Clinically important, potentially hazardous Asthenia (fatigue) (3%) [5]
interactions with: none known Other
Adverse effects [6] Back pain (12%) [4]
prescribing guidelines for: nursing mothers; Diarrhea (12%) [3]
pediatric patients FINGOLIMOD Gastroenteritis (5%)
Hepatotoxicity [10]
Central Nervous System Trade name: Gilenya (Novartis) Respiratory
Headache [2] Indications: Multiple sclerosis Bronchitis (8%)
Class: Immunosuppressant Cough (10%) [3]
Gastrointestinal/Hepatic Half-life: 6–9 days Dyspnea (8%)
Diarrhea [2] Clinically important, potentially hazardous Influenza (13%) [3]
Flatulence [2] interactions with: BCG vaccine, beta blockers, Nasopharyngitis [5]
Loose stools [2] class Ia antiarrhythmics, class III antiarrhythmics, Pulmonary toxicity [4]
Nausea [2] conivaptan, cyproterone, denosumab, digoxin, Respiratory tract infection [2]
Respiratory diltiazem, dronedarone, ketoconazole, Sinusitis (7%)
Nasopharyngitis [2] leflunomide, live vaccines, natalizumab, PEG- Endocrine/Metabolic
Rhinitis [2] interferon, pimecrolimus, QT prolonging drugs, ALT increased (14%) [2]
roflumilast, sipuleucel-T, tacrolimus, tocilizumab, AST increased (14%)
trastuzumab, typhoid vaccine, verapamil, yellow GGT increased (5%)
FINASTERIDE fever vaccine
Weight loss (5%)
Important contra-indications noted in the Hematologic
Trade names: Propecia (Merck), Proscar Leukopenia (3%)
(Merck) prescribing guidelines for: nursing mothers;
pediatric patients Lymphocytopenia [3]
Indications: Benign prostatic hypertrophy, male- Lymphopenia (4%) [10]
pattern baldness Note: Contra-indicated in patients with recent
Class: 5-alpha reductase inhibitor, Androgen (within the last 6 months) occurrence of: Ocular
antagonist, Enzyme inhibitor myocardial infarction, unstable angina, stroke, Macular edema [22]
Half-life: 5–8 hours transient ischemic attack, decompensated heart Ocular pain (3%)
Clinically important, potentially hazardous failure requiring hospitalization, or Class III/IV Vision blurred (4%)
interactions with: none known heart failure; history or presence of Mobitz Type Other
II 2nd degree or 3rd degree AV block or sick sinus
syndrome, unless patient has a pacemaker;
Death [7]
baseline QT interval T500 ms; or is receiving
Infection [16]
treatment with Class Ia or Class III anti-
arrhythmic drugs.
FLAVOXATE See all our books at www.crcpress.com
Ocular
FLAVOXATE Vision blurred [2] FLUCLOXACILLIN
Visual disturbances (16%) [3]
See: www.drugeruptiondata.com/drug/id/292 Trade name: Floxapen (Actavis)
Other Indications: Infections due to sensitive Gram-
Adverse effects [2] positive organisms
FLECAINIDE Class: Antibiotic, beta-lactam
Trade name: Tambocor (3M) FLIBANSERIN Clinically important, potentially hazardous
Indications: Atrial fibrillation interactions with: oral contraceptives,
Class: Antiarrhythmic, Antiarrhythmic class Ic Trade name: Addyi (Sprout) probenecid
Half-life: 12–16 hours Indications: Hypoactive sexual desire disorder in Pregnancy category: N/A
Clinically important, potentially hazardous premenopausal women Important contra-indications noted in the
interactions with: acebutolol, amiodarone, Class: Serotonin type 1A receptor agonist, prescribing guidelines for: nursing mothers
amisulpride, amitriptyline, artemether/ Serotonin type 2A receptor antagonist
lumefantrine, boceprevir, cinacalcet, clozapine, Half-life: 11 hours Skin
cobicistat/elvitegravir/emtricitabine/tenofovir Clinically important, potentially hazardous AGEP [2]
alafenamide, cobicistat/elvitegravir/emtricitabine/ interactions with: alcohol, amprenavir,
atazanavir, boceprevir, carbamazepine, Gastrointestinal/Hepatic
tenofovir disoproxil, darifenacin, delavirdine, Hepatotoxicity [21]
fosamprenavir, lopinavir, mirabegron, quinine, ciprofloxacin, clarithromycin, conivaptan, digoxin,
ritonavir, telaprevir, tipranavir diltiazem, erythromycin, fluconazole, Endocrine/Metabolic
Pregnancy category: C fosamprenavir, grapefruit juice, indinavir, Acidosis [2]
Important contra-indications noted in the itraconazole, ketoconazole, nefazodone, Renal
prescribing guidelines for: nursing mothers; nelfinavir, phenobarbital, phenytoin, Nephrotoxicity [4]
pediatric patients posaconazole, rifabutin, rifampin, rifapentine,
ritonavir, saquinavir, St John’s wort, telaprevir, Hematologic
telithromycin, verapamil Anemia [2]
Skin Pregnancy category: N/A (No data available)
Diaphoresis (<3%) Important contra-indications noted in the
Edema (4%)
Psoriasis [2]
prescribing guidelines for: the elderly; nursing FLUCONAZOLE
Rash (<3%) Warning: HYPOTENSION AND SYNCOPE IN Trade name: Diflucan (Pfizer)
Cardiovascular CERTAIN SETTINGS Indications: Candidiasis
Arrhythmias [7] Class: Antibiotic, triazole, Antifungal, azole,
Atrial fibrillation [3] Mucosal CYP3A4 inhibitor
Atrial flutter [2] Xerostomia (2%) Half-life: 2530 hours
Atrioventricular block [2] Clinically important, potentially hazardous
Bradycardia [4] Central Nervous System interactions with: alprazolam, amphotericin B,
Brugada syndrome [4] Anxiety (2%) anisindione, anticoagulants, atorvastatin, avanafil,
Bundle branch block [2] Insomnia (5%) [2] betamethasone, bosentan, celecoxib, citalopram,
Cardiotoxicity [3] Sedation [2] clobazam, clopidogrel, deflazacort, dicumarol,
Chest pain (5%) Somnolence (drowsiness) (11%) [9] eluxadoline, eplerenone, erythromycin,
Congestive heart failure [2] Vertigo (dizziness) (2%) [9] flibanserin, irbesartan, ivacaftor, lesinurad,
Extrasystoles [2] Neuromuscular/Skeletal methadone, midazolam, mifepristone,
Flushing (<3%) Asthenia (fatigue) (9%) [5] naldemedine, neratinib, nevirapine, olaparib,
Hypotension [2] Gastrointestinal/Hepatic ospemifene, pantoprazole, phenobarbital,
Palpitation (6%) Abdominal pain (2%) phenytoin, pimecrolimus, propranolol,
QT prolongation [7] Constipation (2%) quetiapine, ramelteon, rifapentine, rilpivirine,
Supraventricular tachycardia [2] Nausea (10%) [6] ruxolitinib, simeprevir, sonidegib, sulfonylureas,
Tachycardia [2] temsirolimus, terbinafine, tipranavir, tofacitinib,
Torsades de pointes [4] trabectedin, triamcinolone, venetoclax,
Central Nervous System vinblastine, vincristine, warfarin, zidovudine
Headache (10%) [4]
FLORBETAPIR F18 Pregnancy category: D (fluconazole is
Hyperesthesia (<10%) pregnancy category C for vaginal candidiasis)
Neurotoxicity [3]
Seizures [2] prescribing guidelines for: the elderly; nursing
Syncope [2] mothers
Tremor (5%) FLOXURIDINE
Vertigo (dizziness) (19%) [5] Skin
See: www.drugeruptiondata.com/drug/id/960 AGEP [3]
Asthenia (fatigue) (5–8%) Erythema multiforme [3]
Gastrointestinal/Hepatic Fixed eruption [10]
Abdominal pain (3%) Hypersensitivity (<4%)
Constipation (4%) Rash (2%) [4]
Diarrhea (<3%) [2] Stevens-Johnson syndrome [6]
Nausea (9%) [3] Toxic epidermal necrolysis [4]
Respiratory Hair
Dyspnea (10%) Alopecia [4]
Litt’s Drug Eruption & Reaction Manual FLUORIDES
Nails Hair Neutropenia [6]

Nail changes [2] Alopecia (<10%) Sepsis [2]
Mucosal Mucosal Thrombocytopenia [4]
Oral ulceration [2] Mucositis (2%) Thrombosis (<3%)
Cardiovascular Stomatitis (9%) Otic
Hypotension [2] Cardiovascular Hearing loss (2–6%)
QT prolongation [7] Angina (6%) Ocular
Torsades de pointes [11] Arrhythmias (<4%) Visual disturbances (3–15%)
Central Nervous System Chest pain (5%) Other
Dysgeusia (taste perversion) [2] Congestive heart failure (<4%) Adverse effects [2]
Headache (2–13%) [3] Myocardial infarction (<4%) Death [4]
Neurotoxicity [2] Phlebitis (<3%) Infection (12–44%) [6]
Supraventricular tachycardia (<4%)
Rhabdomyolysis [4] Central Nervous System
Aneurysm (<2%)
Anorexia (7–34%)
FLUDEOXYGLUCOSE
Abdominal pain [2] Cerebrovascular accident (<4%) F18
Diarrhea [2] Chills (11–19%)
Hepatotoxicity [3] Fever (11–69%) [2] See: www.drugeruptiondata.com/drug/id/1761
Nausea (2–7%) Headache (3–9%)
Renal Leukoencephalopathy [9]
Neurotoxicity [3]
Renal failure [2]
Pain (5–22%)
FLUDROCORTISONE
Other
Adverse effects [5] Paresthesias (4–12%) See: www.drugeruptiondata.com/drug/id/1931
Sleep related disorder (<3%)
FLUCYTOSINE Asthenia (fatigue) (6–65%) FLUMAZENIL
Back pain (4–9%)
See: www.drugeruptiondata.com/drug/id/295 Myalgia/Myopathy (>10%) See: www.drugeruptiondata.com/drug/id/297
FLUDARABINE Cholelithiasis (gallstones) (3%) FLUMETASONE
Constipation (<3%)
Trade names: Fludara (Genzyme), Oforta Diarrhea (5–15%) See: www.drugeruptiondata.com/drug/id/1086
(Sanofi-Aventis) Esophagitis (3%)
Indications: Chronic lymphocytic leukemia (B- Gastrointestinal bleeding (3–13%) [2]
Hepatotoxicity [2]
cell)
Class: Antimetabolite, Antineoplastic Nausea (<36%) FLUNISOLIDE
Half-life: 9 hours Respiratory See: www.drugeruptiondata.com/drug/id/1087
Clinically important, potentially hazardous Bronchitis (<9%)
interactions with: aldesleukin, clofazimine, live Cough (6–44%)
vaccines, pentostatin Dyspnea (<22%)
Pregnancy category: D Flu-like syndrome (5–8%) FLUOCINOLONE
Important contra-indications noted in the Hemoptysis (<6%)
prescribing guidelines for: nursing mothers; Pharyngitis (9%) See: www.drugeruptiondata.com/drug/id/1093
pediatric patients Pneumonia (3–22%) [3]
Note: Severe neurologic effects, including Pneumonitis (6%)
blindness, coma, and death were observed in Pulmonary toxicity [4] FLUOCINONIDE
dose-ranging studies in patients with acute Rhinitis (3–11%)
leukemia when fludarabine phosphate was Sinusitis (<5%) See: www.drugeruptiondata.com/drug/id/1092
administered at high doses. Instances of life- Upper respiratory tract infection (2–14%)
threatening and sometimes fatal autoimmune Endocrine/Metabolic
hemolytic anemia have been reported after one
or more cycles of treatment with fludarabine
Hyperglycemia (<6%) FLUORIDES
Weight loss (<6%)
phosphate. Indications: Caries prevention (topical),
Warning: CNS TOXICITY, HEMOLYTIC Genitourinary
Dysuria (3–4%) osteoporosis prevention (oral)
ANEMIA, AND PULMONARY TOXICITY Class: Chemical
Hematuria (<3%)
Urinary hesitancy (3%) Half-life: N/A
Skin Urinary tract infection (4–15%) Clinically important, potentially hazardous
Anaphylactoid reactions/Anaphylaxis (<3%) interactions with: caffeine
Diaphoresis (14%) Hematologic Pregnancy category: C
Edema (8–19%) Anemia [3]
Herpes simplex (7–8%) Cytopenia [2]
Febrile neutropenia [2] Skin
Herpes zoster [2] Acneform eruption [2]
Paraneoplastic pemphigus [4] Hemolytic anemia [2]
Hemotoxicity [3] Burning [12]
Peripheral edema (7%) Dermatitis [4]
Pruritus (<3%) Leukopenia [2]
Myelosuppression [3] Edema [2]
Rash (4–15%) Erythema [2]
Myelotoxicity [2]
FLUORIDES Over 100 updates per week on www.drugeruptiondata.com
Hypersensitivity [6] Rash [8] Renal

Necrosis [2] Recall reaction [3] Proteinuria [4]
Pruritus [5] Seborrheic dermatitis [3] Hematologic
Toxicity [27] Toxicity [4] Anemia [19]
Urticaria [7] Ulcerations [2] Febrile neutropenia [15]
Mucosal Xerosis (<10%) [2] Hemolytic uremic syndrome [3]
Oral ulceration [2] Hair Leukopenia [16]
Stomatitis [3] Alopecia (>10%) [16] Lymphopenia [2]
Central Nervous System Nails Myelosuppression [4]
Headache [2] Nail pigmentation [3] Neutropenia [42]
Paronychia [2] Thrombocytopenia [21]
Arthralgia [5] Mucosal Ocular
Bone or joint pain [12] Epistaxis (nosebleed) [2] Ectropion [2]
Skeletal fluorosis [35] Mucosal inflammation [2] Epiphora [2]
Mucositis (<79%) [15] Ocular inflammation [2]
Abdominal pain [2] Oral mucositis [7] Local
Oral ulceration [2] Application-site edema [2]
Ocular Stomatitis (>10%) [23] Application-site pruritus [3]
Cataract [2] Tongue pigmentation [2] Injection-site burning [2]
Other Cardiovascular Injection-site desquamation [4]
Adverse effects [9] Angina [9] Injection-site edema [3]
Death [7] Bradycardia [2] Injection-site erythema [4]
Tooth fluorosis [39] Cardiac failure [5] Injection-site necrosis [2]
Cardiomyopathy [4] Injection-site pain [2]
Cardiotoxicity [13] Injection-site ulceration [2]
FLUOROURACIL Hypertension [10] Other
Myocardial infarction [4] Adverse effects [8]
Trade names: 5-fluorouracil (Taj), Carac QT prolongation [3] Death [4]
(Valeant), Efudex (Valeant), Fluoroplex (Allergan), Thromboembolism [2] Infection [6]
Fluorouracil Injection, USP (Bioniche), Tolak (Hill Venous thromboembolism [2] Side effects [2]
Dermac) Ventricular tachycardia [2]
Indications: Palliative management of malignant Central Nervous System
neoplasms especially of the gastrointestinal tract,
breast, liver and pancreas, topical therapy for
Anorexia [9] FLUOXETINE
actinic keratoses Encephalopathy [3] Trade names: Prozac (Lilly), Sarafem (Warner
Class: Antimetabolite, Antineoplastic Fever [5] Chilcott), Symbyax (Lilly)
Half-life: 820 minutes Headache [2] Indications: Depression, obsessive-compulsive
Clinically important, potentially hazardous Insomnia [2] disorder
interactions with: aldesleukin, bromelain, Leukoencephalopathy [27] Class: Antidepressant, Selective serotonin
cimetidine, granulocyte colony-stimulating factor Neurotoxicity [12] reuptake inhibitor (SSRI)
(G-CSF), metronidazole, tinidazole Peripheral neuropathy [4] Half-life: 23 days
Pregnancy category: X Vertigo (dizziness) [2] Clinically important, potentially hazardous
Important contra-indications noted in the interactions with: alprazolam, amoxapine,
prescribing guidelines for: nursing mothers; Neuromuscular/Skeletal
Asthenia (fatigue) [18] amphetamines, astemizole, clarithromycin,
pediatric patients clopidogrel, clozapine, desipramine,
Note: Contra-indicated in patients with Gastrointestinal/Hepatic deutetrabenazine, dexibuprofen,
dihydropyrimidine dehydrogenase deficiency. Abdominal pain [4] dextroamphetamine, diethylpropion, droperidol,
Tolak cream contains peanut oil and should be Constipation [3] duloxetine, erythromycin, haloperidol,
used with caution in peanut-sensitive individuals. Diarrhea [31] iloperidone, imipramine, insulin aspart, insulin
Hepatotoxicity [7] degludec, insulin glargine, insulin glulisine,
Skin Nausea [24] isocarboxazid, linezolid, lithium, MAO inhibitors,
Acneform eruption [3] Vomiting [19] mazindol, meperidine, methamphetamine,
Acral erythema [4] Respiratory midazolam, moclobemide, nifedipine,
Actinic keratoses [4] Dysphonia [2] nortriptyline, olanzapine, PEG-interferon,
Anaphylactoid reactions/Anaphylaxis [2] Pulmonary embolism [2] phendimetrazine, phenelzine, phentermine,
Dermatitis (>10%) [4] Endocrine/Metabolic phenylpropanolamine, phenytoin, pimozide,
Eczema [2] Acidosis [2] propranolol, pseudoephedrine, rasagiline,
Edema [2] ALP increased [2] risperidone, selegiline, serotonin agonists,
Erythema [4] ALT increased [2] sibutramine, St John’s wort, sumatriptan,
Erythema multiforme [3] AST increased [2] sympathomimetics, tramadol, tranylcypromine,
Exanthems (<10%) [3] Hyperammonemia [3] trazodone, tricyclic antidepressants,
Hand–foot syndrome (<38%) [54] Hyperglycemia [2] troleandomycin, tryptophan, valbenazine,
Lupus erythematosus [6] Hypocalcemia [2] vortioxetine, zolmitriptan
Palmar–plantar pigmentation [2] Hypokalemia [3] Pregnancy category: C
Peripheral edema [2] Hypomagnesemia [3] Important contra-indications noted in the
Photosensitivity [3] Hyponatremia [3] prescribing guidelines for: the elderly; nursing
Pigmentation [11] Serum creatinine increased [2] mothers; pediatric patients
Pruritus [4] SIADH [4] Note: Increased risk of suicidal thinking and
Radiation recall dermatitis [3] Weight loss [2] behavior in children, adolescents, and young
Litt’s Drug Eruption & Reaction Manual FLUTICASONE FUROATE
adults taking antidepressants for Major Other Pregnancy category: C

Depressive Disorder (MDD) and other Adverse effects [3] Important contra-indications noted in the
psychiatric disorders. Sarafem is not approved for Bruxism [4] prescribing guidelines for: the elderly; nursing
use in pediatric patients with MDD and obsessive Death [3] mothers
compulsive disorder. Symbyax is not approved for Note: NSAIDs may cause an increased risk of
use in children and adolescents. serious cardiovascular and gastrointestinal
Symbyax is fluoxetine and olanzapine. adverse events, which can be fatal. This risk may
Warning: SUICIDAL THOUGHTS AND
FLUOXYMESTERONE increase with duration of use.
BEHAVIORS See: www.drugeruptiondata.com/drug/id/300 Elderly patients are at greater risk for serious
gastrointestinal events.
Skin Warning: CARDIOVASCULAR AND
Diaphoresis (8%) [2] GASTROINTESTINAL RISKS
Exanthems (4%) [7]
FLUPHENAZINE
Mycosis fungoides [2] Trade name: Prolixin (Bristol-Myers Squibb) Skin
Phototoxicity [2] Indications: Psychoses Eczema (39%)
Pruritus (2%) [4] Class: Antipsychotic, Phenothiazine Edema (39%)
Pseudolymphoma [4] Half-life: 8496 hours Exanthems [3]
Rash (6%) [3] Clinically important, potentially hazardous Fixed eruption [2]
Raynaud’s phenomenon [2] interactions with: antihistamines, arsenic, Hypersensitivity [4]
Serum sickness-like reaction [2] chlorpheniramine, clozapine, dofetilide, evening Pruritus (<5%)
Toxic epidermal necrolysis [2] primrose, quinolones, sparfloxacin Rash (<3%)
Toxicity [2] Pregnancy category: C Mucosal
Urticaria (4%) [5] Important contra-indications noted in the Oral lichenoid eruption [2]
Vasculitis [2] prescribing guidelines for: nursing mothers Central Nervous System
Hair Headache [4]
Alopecia [7] Skin Renal
Mucosal Rash (<10%) Nephrotoxicity [2]
Black tongue [2] Vitiligo [2]
Oral ulceration [2] Other
Central Nervous System Side effects (6%) [2]
Xerostomia (12%) [7] Neuroleptic malignant syndrome [14]
Cardiovascular Parkinsonism [3]
Flushing (<2%) Somnolence (drowsiness) [4]
Orthostatic hypotension [2] Neuromuscular/Skeletal
FLUTAMIDE
QT prolongation [7] Dystonia [3]
Torsades de pointes [2] Indications: Metastatic prostate carcinoma
Endocrine/Metabolic Class: Androgen antagonist
Central Nervous System Galactorrhea (<10%) Half-life: 8–10 hours
Akathisia [6] Gynecomastia (<10%) Clinically important, potentially hazardous
Amnesia [2] Mastodynia (<10%) interactions with: none known
Delirium [3] Pregnancy category: D (not indicated for use in
Depression [2] Genitourinary
Priapism [2] women)
Dysgeusia (taste perversion) (2%) Important contra-indications noted in the
Extrapyramidal symptoms [3] Ocular prescribing guidelines for: nursing mothers;
Hallucinations [3] Maculopathy [3] pediatric patients
Headache (<27%) [3] Warning: HEPATIC INJURY
Neuroleptic malignant syndrome [2]
Paresthesias [2]
Restless legs syndrome [4]
FLUPREDNISOLONE Skin
Serotonin syndrome [13] Edema (4%)
See: www.drugeruptiondata.com/drug/id/1941 Hot flashes (61%)
Somnolence (drowsiness) [4]
Suicidal ideation [11] Photosensitivity [9]
Tremor (210%) Rash (3%)
Vertigo (dizziness) [3] FLURAZEPAM Xerosis [2]
See: www.drugeruptiondata.com/drug/id/302 Paresthesias (<10%)
Rhabdomyolysis [2] Gastrointestinal/Hepatic
Gastrointestinal/Hepatic Hepatotoxicity [13]
Nausea [3]
FLURBIPROFEN Endocrine/Metabolic
Endocrine/Metabolic Trade name: Ansaid (Pfizer) Gynecomastia (9%) [4]
Gynecomastia [2] Indications: Rheumatoid arthritis, osteoarthritis Pseudoporphyria [3]
SIADH [20] Class: Non-steroidal anti-inflammatory (NSAID) Local
Weight gain [4] Half-life: 34 hours Injection-site irritation (3%)
Priapism [2] interactions with: ACE inhibitors, aspirin,
Sexual dysfunction [5] furosemide, lithium, methotrexate FLUTICASONE
Ocular
Hallucinations, visual [4]
FUROATE
FLUTICASONE PROPIONATE See all our books at www.crcpress.com
John’s wort, sumatriptan, sympathomimetics, Pruritus [2]

FLUTICASONE tacrine, tasimelteon, tizanidine, tramadol, Urticaria [2]
tranylcypromine, trazodone, troleandomycin,
PROPIONATE tryptophan, zolmitriptan
FOLLITROPIN ALFA/
prescribing guidelines for: the elderly; nursing BETA
FLUVASTATIN Warning: SUICIDALITY AND See: www.drugeruptiondata.com/drug/id/1811
ANTIDEPRESSANT DRUGS
Trade name: Lescol (Novartis)
Indications: Hypercholesterolemia
Class: HMG-CoA reductase inhibitor, Statin
Skin FOMEPIZOLE
Diaphoresis (<7%)
Half-life: 1.2 hours
Photosensitivity [3] See: www.drugeruptiondata.com/drug/id/941
interactions with: azithromycin, bosentan, Mucosal
ciprofibrate, clarithromycin, colchicine, Oral lesions (10%)
cyclosporine, delavirdine, elbasvir & grazoprevir, Xerostomia (<14%) [2] FOMIVIRSEN
erythromycin, gemfibrozil, imatinib, mifepristone, Cardiovascular
red rice yeast Chest pain (3%) See: www.drugeruptiondata.com/drug/id/1202
Pregnancy category: X Palpitation (3%)
Important contra-indications noted in the QT prolongation [3]
Central Nervous System FONDAPARINUX
Anorexia (6–14%)
Skin Anxiety (5–8%) Trade name: Arixtra (Mylan)
Lupus erythematosus [2] Dysgeusia (taste perversion) (3%) Indications: Prophylaxis of deep vein thrombosis
Rash (3%) Headache (22–35%) Class: Anticoagulant, Heparinoid
Central Nervous System Insomnia (21–35%) Half-life: 1721 hours
Neuroleptic malignant syndrome [2] Clinically important, potentially hazardous
Headache (9%)
Pain (10%) interactions with: abciximab, anagrelide,
Neuromuscular/Skeletal anticoagulants, cilostazol, clopidogrel, dabigatran,
Seizures [2]
Asthenia (fatigue) (3%) dipyridamole, eptifibatide, nandrolone, salicylates,
Serotonin syndrome [6]
Myalgia/Myopathy (5%) [4] ticlopidine, tirofiban
Somnolence (drowsiness) (22–27%)
Rhabdomyolysis [13] Pregnancy category: B
Tremor (5–8%)
Gastrointestinal/Hepatic Vertigo (dizziness) (11–15%) Important contra-indications noted in the
Diarrhea (5%) Yawning (2–5%) prescribing guidelines for: the elderly; nursing
Dyspepsia (8%) mothers; pediatric patients
Neuromuscular/Skeletal Warning: SPINAL/EPIDURAL HEMATOMAS
Hepatotoxicity [5]
Respiratory Myalgia/Myopathy (5%)
Sinusitis (3%) Skin
Gastrointestinal/Hepatic Bullous dermatitis (3%)
Diarrhea (16–18%) Edema (9%)
Endocrine/Metabolic Dyspepsia (8–10%) Hematoma [2]
Creatine phosphokinase increased [2] Nausea (34–40%) Hypersensitivity [4]
Other Respiratory Purpura (4%)
Allergic reactions (3%) Pharyngitis (6%) Rash (8%)
Upper respiratory tract infection (9%) Central Nervous System
Endocrine/Metabolic Pain (2%)
FLUVOXAMINE Galactorrhea [2] Gastrointestinal/Hepatic
Libido decreased (2–10%) Hepatotoxicity [2]
Trade name: Luvox (Solvay) SIADH [2]
Indications: Obsessive-compulsive disorder, Local
Genitourinary Injection-site bleeding (<10%)
depression
Ejaculatory dysfunction (8–11%) Injection-site pruritus (<10%)
Class: Antidepressant, CYP1A2 inhibitor,
CYP3A4 inhibitor, Selective serotonin reuptake
inhibitor (SSRI)
Half-life: 15 hours FOLIC ACID FORMOTEROL
interactions with: alosetron, alprazolam, Synonyms: folacin; folate; vitamin B9 Trade names: Dulera (Merck Sharpe & Dohme),
aminophylline, amphetamines, anagrelide, Indications: Anemias Foradil (Novartis), Perforomist (Mylan),
asenapine, astemizole, bendamustine, clobazam, Class: Vitamin Symbicort (AstraZeneca)
clopidogrel, clozapine, dextroamphetamine, Half-life: N/A Indications: Asthma, bronchospasm
diethylpropion, droperidol, duloxetine, Clinically important, potentially hazardous Class: Beta-2 adrenergic agonist, Bronchodilator
isocarboxazid, linezolid, MAO inhibitors, interactions with: balsalazide, estradiol, Half-life: 1014 hours
mazindol, methadone, methamphetamine, raltitrexed Clinically important, potentially hazardous
neratinib, olanzapine, oxtriphylline, Pregnancy category: A interactions with: beta blockers, clomipramine,
phendimetrazine, phenelzine, phentermine, desipramine, doxepin, imipramine, iobenguane,
phenylpropanolamine, pirfenidone, propranolol, Skin nortriptyline, protriptyline, trimipramine
pseudoephedrine, ramelteon, rasagiline, Anaphylactoid reactions/Anaphylaxis [3]
roflumilast, ropivacaine, selegiline, sibutramine, St Exanthems [2]
Litt’s Drug Eruption & Reaction Manual FUROSEMIDE
Pregnancy category: C telithromycin, tipranavir, triazolam, vardenafil, methyldopa, minoxidil, moxisylyte, moxonidine,
Important contra-indications noted in the warfarin nitrates, nitroprusside, NSAIDs, pentoxifylline,
prescribing guidelines for: nursing mothers; Pregnancy category: C phosphodiesterase 5 inhibitors, potassium salts,
pediatric patients Important contra-indications noted in the prostacyclin analogues, rituximab, sirolimus,
Note: Dulera is formoterol and mometasone; prescribing guidelines for: the elderly; nursing spironolactone, sulfonylureas, temsirolimus,
Symbicort is formoterol and budesonide. mothers; pediatric patients tizanidine, tolvaptan, triamterene, trimethoprim
Warning: ASTHMA-RELATED DEATH Note: Fosamprenavir is a sulfonamide and can be Pregnancy category: D (category C in first
absorbed systemically. Sulfonamides can produce trimester; category D in second and third
Skin severe, possibly fatal, reactions such as toxic trimesters)
Pruritus (2%) epidermal necrolysis and Stevens-Johnson Important contra-indications noted in the
syndrome. prescribing guidelines for: nursing mothers
Mucosal Fosamprenavir is a prodrug of amprenavir (see Warning: USE IN PREGNANCY
Xerostomia (<3%) [3] separate entry).
Cardiovascular Skin
Chest pain (2%) Skin Angioedema [3]
Central Nervous System Hypersensitivity [2] Respiratory
Anxiety (2%) Pruritus (7%) Cough [3]
Fever (2%) Rash (~19%) [5]
Headache [8] Central Nervous System
Insomnia (2%)
Tremor (2%) [6]
Depression (8%)
Headache (19%)
FOSPHENYTOIN
Vertigo (dizziness) (2–3%) [2] Paresthesias (oral) (2%) See: www.drugeruptiondata.com/drug/id/311
Neuromuscular/Skeletal Neuromuscular/Skeletal
Back pain (4%) Asthenia (fatigue) (10%)
Cramps (2%)
Leg cramps (2%) Gastrointestinal/Hepatic FROVATRIPTAN
Abdominal pain (5%)
Gastrointestinal/Hepatic Diarrhea [2] See: www.drugeruptiondata.com/drug/id/856
Diarrhea (5%) [2] Hepatotoxicity [2]
Nausea (5%) Vomiting [2]
Vomiting (2%)
Respiratory
Respiratory FULVESTRANT
Bronchitis [2]
Asthma (exacerbation) [3] Cough [2] See: www.drugeruptiondata.com/drug/id/905
Bronchitis (5%) Nasopharyngitis [3]
Cough [5] Rhinitis [2]
Dysphonia [2]
Dyspnea (2%) [2]
Upper respiratory tract infection [2] FURAZOLIDONE
Nasopharyngitis [7] Other
Pharyngitis (4%) [2] Adverse effects [3] See: www.drugeruptiondata.com/drug/id/312
Pneumonia [2]
Rhinitis [2]
Upper respiratory tract infection (7%) [3] FOSCARNET FUROSEMIDE
Genitourinary
See: www.drugeruptiondata.com/drug/id/308 Trade name: Lasix (Sanofi-Aventis)
Indications: Edema
Other Class: Diuretic, loop
Adverse effects [2] Half-life: ~2 hours
Death [2] FOSFOMYCIN Clinically important, potentially hazardous
Infection (17%) interactions with: acemetacin, aliskiren,
amikacin, amyl nitrite, celecoxib, diclofenac,
digoxin, flurbiprofen, gentamicin, hyaluronic acid,
FOSAMPRENAVIR FOSINOPRIL
hydrocortisone, kanamycin, mivacurium,
neomycin, piroxicam, probenecid, streptomycin,
Trade name: Lexiva (ViiV) tobramycin, tolmetin
Indications: HIV infections (in combination with Trade name: Monopril (Bristol-Myers Squibb) Pregnancy category: C
other antiretrovirals) Indications: Hypertension, heart failure Important contra-indications noted in the
Class: Antiretroviral, HIV-1 protease inhibitor Class: Angiotensin-converting enzyme (ACE) prescribing guidelines for: the elderly; nursing
Half-life: 7.7 hours inhibitor, Antihypertensive, Vasodilator mothers; pediatric patients
Clinically important, potentially hazardous Half-life: 12 hours Note: Furosemide is a sulfonamide and can be
interactions with: amiodarone, atorvastatin, Clinically important, potentially hazardous absorbed systemically. Sulfonamides can produce
avanafil, bepridil, carbamazepine, darifenacin, interactions with: alcohol, aldesleukin, severe, possibly fatal, reactions such as toxic
delavirdine, dihydroergotamine, efavirenz, allopurinol, alpha blockers, alprostadil, amifostine, epidermal necrolysis and Stevens-Johnson
etravirine, flecainide, flibanserin, itraconazole, amiloride, angiotensin II receptor blocking agents, syndrome.
ketoconazole, lidocaine, lopinavir, lovastatin, antacids, antidiabetics, antihypertensives,
midazolam, mifepristone, nevirapine, olaparib, antipsychotics, anxiolytics and hypnotics,
azathioprine, baclofen, beta blockers, calcium Skin
phenobarbital, phenytoin, pimozide, AGEP [2]
posaconazole, propafenone, quinidine, quinine, channel blockers, clonidine, corticosteroids,
cyclosporine, diazoxide, diuretics, estrogens, Anaphylactoid reactions/Anaphylaxis [2]
rifabutin, rifampin, rilpivirine, ritonavir, Bullous dermatitis [16]
rivaroxaban, rosuvastatin, sildenafil, simeprevir, general anesthetics, gold & gold compounds,
heparins, hydralazine, hypotensives, insulin, Bullous pemphigoid [11]
simvastatin, St John’s wort, tadalafil, telaprevir, Erythema multiforme [3]
levodopa, lithium, MAO inhibitors, metformin,
FUROSEMIDE Over 100 updates per week on www.drugeruptiondata.com
Exanthems (12%) [7] Vasculitis [7] Otic

Exfoliative dermatitis [3] Mucosal Hearing loss [2]
Lichenoid eruption [2] Xerostomia [3] Ototoxicity [3]
Linear IgA bullous dermatosis [2] Other
Photosensitivity (<10%) [2] Cardiovascular
Hypotension [2] Adverse effects [3]
Phototoxicity [4] Side effects [2]
Pruritus [2] Gastrointestinal/Hepatic
Purpura [3] Pancreatitis [3]
Pustules [3] Endocrine/Metabolic
Stevens-Johnson syndrome [3] Porphyria cutanea tarda [3]
FUSIDIC ACID
Urticaria [3] See: www.drugeruptiondata.com/drug/id/1142
Litt’s Drug Eruption & Reaction Manual GATIFLOXACIN
Ocular Pregnancy category: C

GABAPENTIN Diplopia [2] Important contra-indications noted in the
Hallucinations, visual [2] prescribing guidelines for: nursing mothers;
Trade names: Horizant (GSK), Neurontin Nystagmus [2] pediatric patients
(Pfizer) Vision blurred (3%) Note: Originally derived from snowdrop
Indications: Postherpetic neuralgia in adults, (Galanthus sp) bulbs.
seizures Other
Class: Anticonvulsant Adverse effects [7]
Half-life: 5–7 hours Infection (5%) Skin
Clinically important, potentially hazardous Peripheral edema (>2%)
interactions with: none known Purpura (>2%)
Pregnancy category: C GADOBENATE Cardiovascular
Important contra-indications noted in the Bradycardia (2%) [5]
prescribing guidelines for: the elderly; nursing See: www.drugeruptiondata.com/drug/id/3237 QT prolongation [5]
mothers; pediatric patients Central Nervous System
Anorexia (7–9%) [2]
Skin GADOBUTROL Depression (7%)
Anticonvulsant hypersensitivity syndrome [2] Headache (8%) [2]
Bullous pemphigoid [2] See: www.drugeruptiondata.com/drug/id/1289 Insomnia (5%)
Edema [5] Somnolence (drowsiness) (4%)
Exanthems [2] Syncope (2%) [3]
Peripheral edema (8%) [12] GADODIAMIDE Tremor (3%)
Rash [2] Vertigo (dizziness) (9%) [4]
Stevens-Johnson syndrome [2] See: www.drugeruptiondata.com/drug/id/1063 Neuromuscular/Skeletal
Hair Asthenia (fatigue) (5%)
Alopecia [2] Gastrointestinal/Hepatic
Mucosal GADOFOSVESET Abdominal pain (5%)
Xerostomia (5%) Diarrhea (6–12%) [5]
Central Nervous System See: www.drugeruptiondata.com/drug/id/1259 Dyspepsia (5%)
Aggression [2] Nausea (6–24%) [6]
Coma [3] Vomiting (4–13%) [6]
Confusion [3] GADOPENTETATE Respiratory
Delirium [2] Rhinitis (4%)
Fever (10%) See: www.drugeruptiondata.com/drug/id/3207 Upper respiratory tract infection (>2%)
Gait instability (2%) [4] Endocrine/Metabolic
Headache (3%) [9] Weight loss (5–7%)
Incoordination (2%)
Neurotoxicity [4]
GADOTERIDOL Genitourinary
Psychosis [2] Hematuria (3%)
See: www.drugeruptiondata.com/drug/id/3267 Urinary tract infection (8%)
Sedation [5]
Seizures [4] Hematologic
Somnolence (drowsiness) (21%) [38] Anemia (3%)
Tremor [3] GADOVERSETAMIDE Other
Vertigo (dizziness) (17–28%) [49] Adverse effects [3]
Ataxia (3%) [10] GALSULFASE
Dystonia [2] GADOXETATE
Myalgia/Myopathy [4] See: www.drugeruptiondata.com/drug/id/1115
Myasthenia gravis [3] See: www.drugeruptiondata.com/drug/id/1390
Myoclonus [5]
Rhabdomyolysis [4]
Gastrointestinal/Hepatic GALANTAMINE GANCICLOVIR
Abdominal pain (3%) See: www.drugeruptiondata.com/drug/id/315
Constipation (4%) [2] Trade names: Razadyne (Janssen), Reminyl
Diarrhea (6%) (Janssen)
Flatulence (2%) [2] Indications: Alzheimer’s disease
Nausea (4%) [5] Class: Acetylcholinesterase inhibitor, GANIRELIX
Vomiting (3%) [3] Cholinesterase inhibitor
Half-life: ~7 hours See: www.drugeruptiondata.com/drug/id/316
Respiratory Clinically important, potentially hazardous
Respiratory depression [2] interactions with: bethanechol, cimetidine,
Endocrine/Metabolic donepezil, edrophonium, paroxetine
Weight gain (2%) [8] hydrochloride, physostigmine, pilocarpine,
GATIFLOXACIN
rivastigmine, succinylcholine, tacrine
Genitourinary See: www.drugeruptiondata.com/drug/id/317
Sexual dysfunction [5]
Otic
Hearing loss [2]
GEFITINIB See all our books at www.crcpress.com
GEFITINIB ALT increased [7] Arrhythmias [3]
Appetite decreased [2] Atrial fibrillation [4]
Trade name: Iressa (AstraZeneca) AST increased [6] Capillary leak syndrome [9]
Indications: Advanced non-small cell lung cancer Dehydration [2] Cardiotoxicity [3]
Class: Antineoplastic, Biologic, Epidermal growth Weight loss (3–5%) Hypertension [3]
factor receptor (EGFR) inhibitor, Tyrosine kinase Hypotension [2]
inhibitor Genitourinary
Cystitis [2] Myocardial infarction [3]
Half-life: 48 hours Thromboembolism [2]
Clinically important, potentially hazardous Renal Venous thromboembolism [4]
interactions with: antifungals, BCG vaccine, Nephrotoxicity [2]
boceprevir, carbamazepine, cardiac glycosides, Central Nervous System
Hematologic Anorexia [11]
clozapine, conivaptan, CYP3A4 inhibitors and Anemia [4]
inducers, dasatinib, deferasirox, denosumab, Fever (41%) [13]
Neutropenia [6] Leukoencephalopathy [4]
echinacea, efavirenz, grapefruit juice, Thrombocytopenia [3]
itraconazole, leflunomide, natalizumab, Neurotoxicity [10]
phenobarbital, phenytoin, pimecrolimus, Ocular Pain [2]
ranitidine, rifampin, rifapentine, sipuleucel-T, St Amblyopia (2%) Paresthesias (10%) [2]
John’s wort, tacrolimus, topotecan, trastuzumab, Blepharitis [2] Peripheral neuropathy [5]
vaccines, vitamin K antagonists, voriconazole, Conjunctivitis [2] Somnolence (drowsiness) (11%)
warfarin Other Neuromuscular/Skeletal
Pregnancy category: D Adverse effects [11] Asthenia (fatigue) (18%) [44]
Important contra-indications noted in the Death [8] Myalgia/Myopathy (>10%) [6]
pediatric patients Abdominal pain [2]
GEMCITABINE Cholangitis [2]
Skin Constipation [3]
Acneform eruption (25–33%) [32] Trade name: Gemzar (Lilly) Diarrhea (19%) [25]
Desquamation (39%) [2] Indications: Pancreatic carcinoma as a single Gastrointestinal bleeding [2]
Exanthems [3] agent, ovarian cancer (with carboplatin), breast Hepatic disorder [2]
Folliculitis [4] cancer (with paclitaxel), non-small cell lung cancer Hepatotoxicity [11]
Hand–foot syndrome [2] (with cisplatin) Nausea (69%) [25]
Papulopustular eruption [3] Class: Antimetabolite, Antineoplastic Vomiting (69%) [20]
Peripheral edema (2%) Half-life: 42–94 minutes for short infusions; 4–11 Respiratory
Pruritus (8–9%) [5] hours for longer infusions Dyspnea (10–23%) [2]
Rash (43–54%) [63] Clinically important, potentially hazardous Flu-like syndrome (19%) [2]
Seborrhea [2] interactions with: aldesleukin Pneumonitis [5]
Toxicity [10] Pregnancy category: D Pulmonary toxicity [11]
Ulcerations [2] Important contra-indications noted in the
Xerosis (13–26%) [12] prescribing guidelines for: nursing mothers; Endocrine/Metabolic
pediatric patients ALT increased [6]
Hair Appetite decreased [2]
Alopecia [6] AST increased [6]
Hypertrichosis [2] Skin Dehydration [2]
Nails Acneform eruption [3] Hypomagnesemia [7]
Nail changes (17%) Bullous dermatitis [2] Hyponatremia [2]
Paronychia (6%) [13] Cellulitis [5]
Dermatitis [6] Genitourinary
Pyogenic granuloma [2] Hematuria (30%)
Eczema (13%)
Mucosal Edema (13%) [4] Renal
Mucositis [4] Exanthems [2] Nephrotoxicity [5]
Stomatitis [7] Hand–foot syndrome [19] Renal failure [2]
Cardiovascular Hypersensitivity [3] Hematologic
Hypertension [2] Livedo reticularis [2] Anemia (70%) [38]
Central Nervous System Necrosis [2] Febrile neutropenia [17]
Anorexia (7–10%) [2] Peripheral edema (20%) [4] Hemolytic uremic syndrome [32]
Petechiae (16%) Hemotoxicity [6]
Neuromuscular/Skeletal Pruritus (13%) [2]
Asthenia (fatigue) [11] Leukocytopenia [3]
Radiation recall dermatitis (<74%) [17] Leukopenia (62%) [24]
Gastrointestinal/Hepatic Rash (30%) [35] Myelosuppression [7]
Abdominal pain [3] Raynaud’s phenomenon [3] Myelotoxicity [3]
Diarrhea (48–67%) [37] Thrombocytopenic purpura [6] Neutropenia (61%) [87]
Gastrointestinal perforation [2] Toxic epidermal necrolysis [3] Thrombocytopenia (30%) [63]
Hepatotoxicity [26] Toxicity [5] Thrombosis [3]
Nausea (13–18%) [9] Vasculitis [3] Thrombotic microangiopathy [4]
Vomiting (9–12%) [5] Hair Local
Respiratory Alopecia (15%) [15] Injection-site reactions (4%)
Dyspnea (2%) Mucosal
Pneumonia [2] Other
Mucositis [7] Adverse effects [9]
Pneumonitis [4] Stomatitis (11%) [13]
Pulmonary toxicity [16] Allergic reactions (4%)
Litt’s Drug Eruption & Reaction Manual GLATIRAMER
Death [11] Anaphylactoid reactions/Anaphylaxis [3]

Infection (16%) [9] GENTAMICIN Cyst (2%)
Diaphoresis (15%)
Trade names: Garamycin (Schering), Genoptic Ecchymoses (8%)
(Allergan)
GEMEPROST Indications: Various infections caused by
Eczema (8%)
Edema (8%)
susceptible organisms Erythema (4%)
See: www.drugeruptiondata.com/drug/id/1375 Class: Antibiotic, aminoglycoside Facial edema (6%)
Half-life: 24 hours Herpes simplex (4%)
Clinically important, potentially hazardous Hyperhidrosis (15%)
GEMFIBROZIL interactions with: adefovir, aldesleukin, Hypersensitivity (3%)
aminoglycosides, atracurium, bumetanide, Lipoatrophy [3]
Trade name: Lopid (Pfizer) carbenicillin, cephalexin, cephalothin, cobicistat/ Nicolau syndrome [3]
Indications: Hyperlipidemia elvitegravir/emtricitabine/tenofovir alafenamide, Nodular eruption (2%)
Class: Fibrate, Lipid regulator doxacurium, ethacrynic acid, furosemide, Panniculitis [2]
Half-life: 2 hours methoxyflurane, non-polarizing muscle relaxants, Peripheral edema (7%)
Clinically important, potentially hazardous pancuronium, pipecuronium, polypeptide Pruritus (4%)
interactions with: atorvastatin, bexarotene, antibiotics, rocuronium, succinylcholine, Purpura (8%)
colchicine, cyclosporine, dasabuvir/ombitasvir/ teicoplanin, torsemide, tubocurarine, vecuronium Rash (18%)
paritaprevir/ritonavir, dicumarol, eluxadoline, Pregnancy category: C
enzalutamide, ezetimibe, fluvastatin, interferon Important contra-indications noted in the Hair
alfa, lovastatin, nicotinic acid, paclitaxel, prescribing guidelines for: the elderly; nursing Alopecia (>2%)
pioglitazone, pitavastatin, pravastatin, repaglinide, mothers Nails
rosiglitazone, rosuvastatin, roxithromycin, Note: Aminoglycosides may cause neurotoxicity Nail changes (>2%)
selexipag, simvastatin, treprostinil, warfarin and/or nephrotoxicity. Mucosal
Pregnancy category: C Oral vesiculation (6%)
Important contra-indications noted in the Skin Xerostomia (>2%)
prescribing guidelines for: nursing mothers; Anaphylactoid reactions/Anaphylaxis [2]
pediatric patients Cardiovascular
Dermatitis [8] Chest pain (13%) [2]
Note: Contra-indicated in patients with Edema (<10%)
preexisting gallbladder disease. Flushing [5]
Erythema (<10%) Palpitation (7%) [6]
Exanthems [5] Vasodilation (20%) [2]
Skin Photosensitivity [2]
Eczema (2%) Pruritus (<10%) Central Nervous System
Exanthems (3%) [2] Anxiety (13%) [3]
Hair Chills (4%)
Psoriasis [3] Alopecia [2]
Rash (2%) Depression (>2%)
Renal Dysgeusia (taste perversion) (>2%)
Central Nervous System Fanconi syndrome [2] Fever (6%)
Headache [3] Nephrotoxicity [15] Hyperesthesia (>2%)
Neuromuscular/Skeletal Otic Migraine (4%)
Asthenia (fatigue) (2%) Ototoxicity [12] Pain (28%) [2]
Compartment syndrome [2] Tinnitus [4] Paresthesias (>2%) [2]
Myalgia/Myopathy [5] Tremor (7%)
Rhabdomyolysis [35] Local Vertigo (dizziness) (>2%)
Injection-site necrosis [5]
Gastrointestinal/Hepatic Neuromuscular/Skeletal
Abdominal pain (10%) Arthralgia (24%)
Dyspepsia (20%) Asthenia (fatigue) (19%)
Hepatotoxicity [2] GESTRINONE Myalgia/Myopathy (>2%)
Pancreatitis [2] Gastrointestinal/Hepatic
Other Hepatotoxicity [3]
Death [2] Nausea (15%)
Vomiting (7%)
GLATIRAMER Respiratory
GEMIFLOXACIN Synonym: copolymer-1 Cough (>2%)
Trade names: Copaxone (Teva), Glatopa Dyspnea [3]
See: www.drugeruptiondata.com/drug/id/967 (Novartis) Flu-like syndrome (26%)
Indications: Multiple sclerosis Sinusitis (>2%)
Class: Immunomodulator Endocrine/Metabolic
GEMTUZUMAB Half-life: N/A Mastodynia (>2%)
Clinically important, potentially hazardous Genitourinary
See: www.drugeruptiondata.com/drug/id/320 interactions with: Hemophilus B vaccine Urinary tract infection [2]
Pregnancy category: B Vaginitis (4%)
prescribing guidelines for: the elderly; nursing Otic
mothers; pediatric patients Tinnitus (>2%)
Local
Skin Injection-site bleeding (5%)
Acneform eruption (>2%) Injection-site ecchymoses (>2%)
Injection-site edema [2]
GLATIRAMER Over 100 updates per week on www.drugeruptiondata.com
Injection-site erythema (66%) [4] Central Nervous System

Injection-site induration (13%) [3] GLIMEPIRIDE Hyperesthesia (<3%)
Injection-site inflammation (49%) Paresthesias (<3%)
Injection-site lipoatrophy/lipohypertrophy Trade names: Amaryl (Sanofi-Aventis),
Avandaryl (GSK) Neuromuscular/Skeletal
[2] Myalgia/Myopathy (<3%)
Injection-site pain (73%) [3] Indications: Non-insulin dependent diabetes
Injection-site pruritus (40%) [3] Type ll Endocrine/Metabolic
Injection-site reactions (667%) [15] Class: Sulfonylurea Hypoglycemia [3]
Injection-site urticaria (5%) Half-life: 59 hours Other
Clinically important, potentially hazardous Adverse effects [2]
Other interactions with: none known
Adverse effects [5] Pregnancy category: C
Infection (50%) [2] Important contra-indications noted in the
prescribing guidelines for: the elderly; nursing GLUCAGON
GLECAPREVIR & Note: Glimepiride is a sulfonamide and can be Trade name: Glucagon Emergency Kit (Lilly)
Indications: Hypoglycemic reactions
absorbed systemically. Sulfonamides can produce
PIBRENTASVIR * severe, possibly fatal, reactions such as toxic Class: Hormone, polypeptide
epidermal necrolysis and Stevens-Johnson Half-life: 310 minutes
Trade name: Mavyret (AbbVie) syndrome Clinically important, potentially hazardous
Indications: Chronic HCV genotype 1–6 Avandaryl is glimepiride and rosiglitazone. interactions with: insulin degludec, insulin
infection glargine, insulin glulisine, warfarin
Class: Direct-acting antiviral, Hepatitis C virus Pregnancy category: B
NS3/4A protease inhibitor (glecaprevir), Hepatitis Central Nervous System
C virus NS5A inhibitor (pibrentasvir) Headache [4]
Vertigo (dizziness) [2] Skin
Half-life: 6 hours (glecaprevir); 13 hours Erythema necrolyticum migrans [2]
(pibrentasvir) Neuromuscular/Skeletal Exanthems [7]
Clinically important, potentially hazardous Arthralgia [2] Folliculitis [2]
interactions with: atazanavir, atorvastatin, Gastrointestinal/Hepatic Pyoderma gangrenosum [3]
carbamazepine, cyclosporine, darunavir, Diarrhea [5] Rash [2]
efavirenz, lopinavir, lovastatin, oral Dyspepsia [2] Sweet’s syndrome [7]
contraceptives, rifampin, ritonavir, simvastatin, St Nausea [4] Urticaria (<10%) [2]
John’s wort Pancreatitis [2] Vasculitis [9]
to inform drug-associated risk) Endocrine/Metabolic Local
Important contra-indications noted in the Hypoglycemia [8] Injection-site reactions [3]
prescribing guidelines for: nursing mothers; Weight gain [3]
pediatric patients Genitourinary
Note: Contra-indicated in patients with severe Genital mycotic infections [3] GLUCARPIDASE
hepatic impairment (Child-Pugh C). Urinary tract infection [3]
Warning: RISK OF HEPATITIS B VIRUS Other See: www.drugeruptiondata.com/drug/id/2737
REACTIVATION IN PATIENTS COINFECTED Adverse effects [5]
WITH HCV AND HBV
GLUCOSAMINE
Central Nervous System GLIPIZIDE
Headache (13%) [2] Trade names: Arthro-Aid (NutraSense),
Neuromuscular/Skeletal Trade names: Glucotrol (Pfizer), Metaglip Glucosamine sulfate (Rottapharm)
Asthenia (fatigue) (11%) [2] (Bristol-Myers Squibb) Indications: Arthritis, osteoarthritis, cartilage
Indications: Non-insulin dependent diabetes repair and maintenance, strained joints, improving
Gastrointestinal/Hepatic joint function and range of motion, alleviating joint
Nausea (8%) Type ll
Class: Sulfonylurea pain
Endocrine/Metabolic Half-life: 24 hours Class: Amino sugar, Food supplement
Hyperbilirubinemia (<4%) Clinically important, potentially hazardous Half-life: N/A
Other interactions with: none known Clinically important, potentially hazardous
Adverse effects [2] Pregnancy category: C interactions with: abciximab, cilostazol,
Important contra-indications noted in the citalopram, clopidogrel, eptifibatide, meloxicam
prescribing guidelines for: the elderly; nursing Pregnancy category: C
GLICLAZIDE Note: Glipizide is a sulfonamide and can be Mucosal
See: www.drugeruptiondata.com/drug/id/1329 absorbed systemically. Sulfonamides can produce Oral vesiculation (7%)
severe, possibly fatal, reactions such as toxic Central Nervous System
epidermal necrolysis and Stevens-Johnson Depression (6%)
syndrome.
Skin
Photosensitivity (<10%) Gastrointestinal/Hepatic
Pruritus (<3%) Dyspepsia [2]
Rash (<10%) Hepatotoxicity [3]
Urticaria (<10%) Nausea [2]
Litt’s Drug Eruption & Reaction Manual GREPAFLOXACIN
Other Skin Central Nervous System

Adverse effects (6%) [4] Photosensitivity (<10%) Headache [7]
Allergic reactions (4%) [2] Xerosis (>10%) Neuromuscular/Skeletal
Mucosal Arthralgia [3]
Nasal congestion (30%)
GLYBURIDE Xerostomia (40%) [9] Gastrointestinal/Hepatic
Cardiovascular Colitis [2]
Synonyms: glibenclamide; glybenclamide Diarrhea [4]
Trade names: Diabeta (Sanofi-Aventis), Bradycardia [2]
Flushing (30%) Nausea [6]
Glucovance (Bristol-Myers Squibb), Glynase
(Pfizer), Micronase (Pfizer) Central Nervous System Respiratory
Indications: Non-insulin dependent diabetes Headache (15%) [2] Cough [2]
Type ll Nasopharyngitis (6%) [7]
Gastrointestinal/Hepatic Pneumonia [4]
Class: Sulfonylurea
Constipation (35%) Pulmonary toxicity [2]
Vomiting (40%) Tuberculosis [2]
interactions with: bosentan, colesevelam, Respiratory Upper respiratory tract infection (7%) [7]
norfloxacin Sinusitis (15%) Endocrine/Metabolic
Pregnancy category: C Upper respiratory tract infection (15%) ALT increased [4]
Note: Glyburide is a sulfonamide and can be Genitourinary AST increased [3]
absorbed systemically. Sulfonamides can produce Urinary retention (15%) Genitourinary
severe, possibly fatal, reactions such as toxic
Ocular Urinary tract infection [2]
epidermal necrolysis and Stevens-Johnson
syndrome.
Mydriasis [2] Hematologic
Glucovance is glyburide and metformin. Local Sepsis [4]
Injection-site irritation (>10%) Local
Skin Injection-site erythema [7]
Erythema (<5%) Injection-site reactions (6%) [7]
Exanthems (<5%) [3] GOLD & GOLD Other
Linear IgA bullous dermatosis [2] Adverse effects [12]
Pemphigus [2] COMPOUNDS Death [3]
Photosensitivity (<10%) [5] Infection (28%) [16]
Pruritus (<10%) [3] See: www.drugeruptiondata.com/drug/id/327
Psoriasis [2]
Purpura [2]
Rash (<10%) GOLIMUMAB GOSERELIN
Urticaria (<5%) [4]
Vasculitis [5] Trade name: Simponi (Centocor)
Cardiovascular Indications: Rheumatoid arthritis, psoriatic
Flushing [2] arthritis, ankylosing spondylitis, ulcerative colitis
Class: Disease-modifying antirheumatic drug GRANISETRON
Endocrine/Metabolic (DMARD), Monoclonal antibody, TNF inhibitor
Hypoglycemia [2] Half-life: 2 weeks See: www.drugeruptiondata.com/drug/id/329
Weight gain [2] Clinically important, potentially hazardous
Other interactions with: abatacept, anakinra, live
Adverse effects [2] vaccines GRANULOCYTE
Important contra-indications noted in the COLONY-
GLYCOPYRROLATE prescribing guidelines for: nursing mothers;
pediatric patients STIMULATING FACTOR
Note: TNF inhibitors should be used in patients
Synonym: glycopyrronium bromide
with heart failure only after consideration of other
(G-CSF)
Trade names: Cuvposa (Shionogi), Robinul
(Forte), Seebri Neohaler (Novartis), Utibron treatment options. TNF inhibitors are contra-
Neohaler (Novartis) indicated in patients with a personal or family
Indications: Duodenal ulcer, irritable bowel history of multiple sclerosis or demyelinating
syndrome, hyperhidrosis disease. TNF inhibitors should not be
Class: Anticholinergic, Muscarinic antagonist, administered to patients with moderate to severe GREPAFLOXACIN
Non-depolarizing muscle relaxant heart failure (New York Heart Association
Functional Class III/IV). See: www.drugeruptiondata.com/drug/id/331
Half-life: N/A
Clinically important, potentially hazardous Warning: SERIOUS INFECTIONS AND
interactions with: anticholinergics, arbutamine, MALIGNANCY
belladonna alkaloids, digoxin, disopyramide,
meperidine, phenothiazines, procainamide, Skin
quinidine, ritodrine, tricyclic antidepressants Lupus erythematosus [3]
Pregnancy category: C Malignancies [5]
Important contra-indications noted in the Psoriasis [2]
prescribing guidelines for: the elderly; nursing Rash [3]
mothers; pediatric patients Cardiovascular
Note: Utibron Neohaler is glycopyrrolate and Hypertension [2]
indacaterol.
GRISEOFULVIN See all our books at www.crcpress.com
Urticaria (>10%) [5]

GRISEOFULVIN Vasculitis [2] GUSELKUMAB *
Trade names: Fulvicin (Schering), Grifulvin V Mucosal Trade name: Tremfya (Janssen Biotech)
(Ortho), Gris-PEG (Pedinol) Oral candidiasis (<10%) Indications: Plaque psoriasis
Indications: Fungal infections of the skin, hair Central Nervous System Class: Interleukin-23 inhibitor, Monoclonal
and nails Dysgeusia (taste perversion) [3] antibody
Class: Antifungal Endocrine/Metabolic Half-life: 15–18 days
Half-life: 924 hours Gynecomastia [2] Clinically important, potentially hazardous
Clinically important, potentially hazardous Porphyria [12] interactions with: live vaccines
interactions with: alcohol, levonorgestrel, Pregnancy category: N/A (Insufficient evidence
liraglutide, midazolam, thalidomide, ulipristal Other to inform drug-associated risk)
Pregnancy category: C Adverse effects [2] Important contra-indications noted in the
Important contra-indications noted in the Allergic reactions (<5%) prescribing guidelines for: nursing mothers;
prescribing guidelines for: nursing mothers; pediatric patients
pediatric patients
GUANABENZ Central Nervous System
Skin Headache (5%) [3]
Angioedema [3] See: www.drugeruptiondata.com/drug/id/333
Bullous dermatitis [2] Arthralgia (3%)
Cold urticaria [2] Back pain [2]
Erythema multiforme [6] GUANADREL Gastrointestinal/Hepatic
Exanthems [6]
Exfoliative dermatitis [2] See: www.drugeruptiondata.com/drug/id/334 Diarrhea (2%)
Fixed eruption [7] Hepatotoxicity (3%)
Lichenoid eruption [2] Respiratory
Petechiae [2]
GUANETHIDINE Nasopharyngitis [5]
Photosensitivity (<10%) [18] See: www.drugeruptiondata.com/drug/id/335 Local
Pigmentation [2] Injection-site reactions (5%)
Pruritus [4]
Rash (>10%) Other
Serum sickness-like reaction [3] GUANFACINE Infection [3]
Toxic epidermal necrolysis [4] See: www.drugeruptiondata.com/drug/id/336
Litt’s Drug Eruption & Reaction Manual HEPATITIS A VACCINE
Vertigo (dizziness) [2] Pregnancy category: C

HALCINONIDE Neuromuscular/Skeletal Important contra-indications noted in the
Dystonia [3] prescribing guidelines for: the elderly
See: www.drugeruptiondata.com/drug/id/1083 Note: A higher incidence of bleeding has been
Myoclonus [2]
Rhabdomyolysis [7] reported in patients over 60 years of age,
especially women. Contra-indicated in patients
HALOBETASOL Gastrointestinal/Hepatic with severe thrombocyopenia.
Constipation [2]
See: www.drugeruptiondata.com/drug/id/1097 Pancreatitis [2]
Skin
Respiratory Anaphylactoid reactions/Anaphylaxis [4]
Pneumonia [2] Bullous dermatitis [4]
HALOFANTRINE Endocrine/Metabolic Dermatitis [6]
Galactorrhea [4] Ecchymoses [3]
See: www.drugeruptiondata.com/drug/id/1327 Hyperprolactinemia [2] Erythema [2]
Hypoglycemia [2] Exanthems [2]
SIADH [3] Hypersensitivity [17]
HALOMETASONE Weight gain [2] Lesions [2]
Genitourinary Livedo reticularis [2]
See: www.drugeruptiondata.com/drug/id/1098 Priapism [3] Necrosis [56]
Urinary retention [3] Petechiae [2]
Purpura (>10%)
Local Toxic epidermal necrolysis [2]
HALOPERIDOL Injection-site reactions [3] Urticaria [6]
Other Vasculitis [6]
Trade name: Haldol (Ortho-McNeil) Adverse effects [4]
Indications: Schizophrenia, Tourette’s disorder Hair
Death [7] Alopecia [2]
Class: Antiemetic, Antipsychotic
Half-life: 20 hours Mucosal
Clinically important, potentially hazardous Gingivitis (>10%)
interactions with: acemetacin, arsenic, HALOTHANE Genitourinary
benztropine, citalopram, clozapine, darifenacin, Priapism [6]
fluoxetine, itraconazole, lisdexamfetamine, See: www.drugeruptiondata.com/drug/id/338
lithium, meloxicam, methotrexate, moxifloxacin, Hematologic
nilotinib, oxybutynin, propranolol, quinine, Bleeding [2]
ribociclib, sotalol, sulpiride, tetrabenazine, HEMOPHILUS B Hemorrhage [6]
tiotropium, trospium, vandetanib, venlafaxine Thrombocytopenia [97]
Pregnancy category: C VACCINE Thrombosis [9]
Important contra-indications noted in the Local
prescribing guidelines for: the elderly; pediatric Trade names: ActHIB (Sanofi-Aventis), Comvax Injection-site eczematous eruption [5]
patients (Merck), HibTITER (Lederle), OmniHIB (GSK), Injection-site induration [4]
Warning: INCREASED MORTALITY IN PedivaxHIB (Merck), ProHIBIT (Connaught) Injection-site necrosis [4]
ELDERLY PATIENTS WITH DEMENTIA- Indications: Hemophilus B immunization Injection-site plaques [2]
RELATED PSYCHOSIS Class: Vaccine
Half-life: N/A
Other
Allergic reactions (<10%) [3]
Skin Death [6]
interactions with: azathioprine, basiliximab,
Cellulitis [2]
corticosteroids, cyclosporine, daclizumab,
Diaphoresis [2]
glatiramer, mycophenolate, sirolimus, tacrolimus
Photosensitivity [3] HEPATITIS A VACCINE
Seborrheic dermatitis [2]
Hair Trade names: Avaxim (Sanofi Pasteur), Havrix
Skin
Alopecia areata [2] (GSK), Vaqta (Merck)
Erythema [2]
Mucosal Indications: Hepatitis A immunization
Xerostomia [4] Class: Vaccine
Half-life: >2 years
Cardiovascular HEPARIN Clinically important, potentially hazardous
Arrhythmias [2] interactions with: none known
QT prolongation [22] Trade names: Hep-Flush (Wyeth), Viaflex Pregnancy category: C
Torsades de pointes [12] (Baxter)
Central Nervous System Indications: Venous thrombosis, pulmonary
embolism, intravascular coagulation, peripheral
Skin
Agitation [4] Rash (<10%)
Akathisia [9] arterial embolism
Delirium [3] Class: Anticoagulant, Heparinoid Central Nervous System
Extrapyramidal symptoms [9] Half-life: 2 hours Anorexia (<10%)
Insomnia [3] Clinically important, potentially hazardous Chills (<10%)
Neuroleptic malignant syndrome [36] interactions with: acenocoumarol, aliskiren, Fever (>10%) [2]
Parkinsonism [8] antihistamines, aspirin, balsalazide, bivalirudin, Guillain–Barré syndrome [2]
Sedation [3] butabarbital, ceftobiprole, dabigatran, danaparoid, Headache (>10%) [3]
Somnolence (drowsiness) [5] defibrotide, desvenlafaxine, iloprost, nandrolone, Somnolence (drowsiness) (>10%)
Tardive dyskinesia (<37%) [5] nicotine, nitroglycerin, palifermin, piperacillin/ Neuromuscular/Skeletal
Tremor [7] tazobactam, salicylates, tirofiban, warfarin Arm pain (<10%)
HEPATITIS A VACCINE Over 100 updates per week on www.drugeruptiondata.com
Asthenia (fatigue) (<10%) Ocular

Back pain (<10%) Optic neuropathy [3] HUMAN PAPILLOMA-
Uveitis [2]
Gastrointestinal/Hepatic VIRUS (HPV) VACCINE
Constipation (<10%) Local
Diarrhea (<10%) Injection-site edema [2] Synonym: HPV4
Nausea (<10%) Injection-site pain (22%) [3] Trade names: Gardasil (Merck), Silgard (Merck)
Vomiting (<10%) Other Indications: For prevention of HPV genital
Respiratory Adverse effects [2] warts, cervical cancers and vulvar dysplasias
Cough (<10%) Death [2] (against Types 6, 11, 16 and 18 human
Nasopharyngitis (<10%) papillomavirus)
Pharyngitis (<10%) Class: Vaccine
Rhinitis (<10%) Half-life: N/A
Upper respiratory tract infection (<10%)
HEROIN Clinically important, potentially hazardous
interactions with: immunosuppressants
Otic Synonym: diacetylmorphine Pregnancy category: B
Otitis media (<10%) Indications: Substance abuse drug Important contra-indications noted in the
Ocular Class: Opiate agonist prescribing guidelines for: the elderly; nursing
Conjunctivitis (<10%) Half-life: N/A mothers; pediatric patients
Local interactions with: none known
Injection-site erythema [2] Pregnancy category: B (category D if used for Mucosal
Injection-site pain (<10%) [7] prolonged period or in high doses) Oropharyngeal pain (3%)
Injection-site reactions [5]
Other Skin Cognitive impairment [2]
Adverse effects [2] Abscess [7] Fever (13%) [4]
Acanthosis nigricans [2] Headache (28%) [8]
Burning (24%) Myelitis [2]
HEPATITIS B VACCINE Candidiasis [3] Vertigo (dizziness) (<4%) [2]
Cellulitis [3] Neuromuscular/Skeletal
Trade names: Comvax (Merck), Engerix B Edema [4] Asthenia (fatigue) [5]
(GSK), Pediatrix (GSK), Recombivax HB (Merck), Exanthems [2]
Twinrix (GSK) Fixed eruption [2]
Diarrhea (3–4%)
Other common trade names: Heptavax-B Folliculitis (candidal) [4]
Nausea (2–7%) [2]
Indications: For immunization of infection Necrosis [3]
Vomiting (<2%)
caused by all known subtypes of hepatitis B virus Photosensitivity [2]
Class: Vaccine Pigmentation [4] Respiratory
Half-life: N/A Pruritus [6] Cough (2%)
Clinically important, potentially hazardous Pustules [5] Nasopharyngitis (3%)
interactions with: none known Toxic epidermal necrolysis [2] Upper respiratory tract infection (2%)
Pregnancy category: C Ulcerations [5] Local
Urticaria [3] Injection-site bruising (3%)
Skin Vasculitis [2] Injection-site edema (14–25%) [2]
Anaphylactoid reactions/Anaphylaxis [6] Central Nervous System Injection-site erythema (17–25%) [2]
Churg-Strauss syndrome [2] Leukoencephalopathy [12] Injection-site pain (61–84%) [4]
Dermatomyositis [2] Seizures (2%) Injection-site pruritus (3%)
Erythema multiforme [2] Injection-site reactions [4]
Erythema nodosum [3] Myalgia/Myopathy [2] Other
Gianotti–Crosti syndrome [2] Rhabdomyolysis [15] Adverse effects [4]
Granuloma annulare [2] Toothache (2%)
Lichen planus [17] Otic
Lichenoid eruption [3] Hearing loss [2]
Lupus erythematosus [9] Ocular
Pemphigus [2] Diplopia [2]
HUMAN PAPILLOMA-
Pseudolymphoma [2]
Purpura [6]
Eyelid edema [2] VIRUS VACCINE
Local
Raynaud’s phenomenon [2] Injection-site ulceration [3] (BIVALENT)
Urticaria [3]
Vasculitis [11] Other Trade name: Cervarix (GSK)
Death [5] Indications: Prevention of human papillomavirus
Hair Infection (13%)
Alopecia [2] (HPV) types 16 and 18 in females aged 10–25
Side effects (85%) years old
Cardiovascular Teratogenicity [2] Class: Vaccine
Polyarteritis nodosa [5] Half-life: N/A
Central Nervous System Clinically important, potentially hazardous
Guillain–Barré syndrome [4] HISTRELIN interactions with: immunosuppressants
Neurotoxicity [2] Pregnancy category: B
Neuromuscular/Skeletal See: www.drugeruptiondata.com/drug/id/1111 Important contra-indications noted in the
Arthralgia [4] prescribing guidelines for: the elderly; nursing
Litt’s Drug Eruption & Reaction Manual HYDROCHLOROTHIAZIDE
Skin Inflammation [7] Mucosal

Anaphylactoid reactions/Anaphylaxis (3%) Necrosis [3] Oral ulceration [2]
[2] Nodular eruption [2] Orogenital ulceration [2]
Erythema (<10%) [4] Pruritus [4] Cardiovascular
Pruritus (<10%) Cardiovascular Flushing (>10%)
Rash (<10%) Arterial occlusion [2]
Urticaria (7%) Gastrointestinal/Hepatic
Hypertension (4%) Hepatotoxicity [2]
Central Nervous System Central Nervous System
Fever (13%) [3] Respiratory
Pain [3] Alveolar hemorrhage (pulmonary) [2]
Headache (53%) [2]
Neuromuscular/Skeletal Renal
Neuromuscular/Skeletal Arthralgia [8]
Arthralgia (21%) Glomerulonephritis [5]
Back pain (5%)
Asthenia (fatigue) (55%) Chondritis (<11%) [2]
Myalgia/Myopathy (49%) Gouty tophi [3]
Gastrointestinal/Hepatic Tendinitis (2%) HYDROCHLORO-
Diarrhea (28%)
Gastrointestinal/Hepatic THIAZIDE
Nausea (2%)
Nausea (28%)
Ocular Trade names: Accuretic (Pfizer), Aldactazide
Vomiting (28%)
Orbital inflammation [2] (Pfizer), Aldoril (Merck), Atacand HCT
Local (AstraZeneca), Avalide (Bristol-Myers Squibb),
Injection-site edema (44%) [3] Local
Capozide (Par), Diovan HCT (Novartis), Dyazide
Injection-site erythema (48%) Injection-site bruising [3]
(GSK), Hyzaar (Merck), Inderide (Wyeth),
Injection-site pain (92%) [9] Injection-site ecchymoses [2]
Lopressor (Novartis), Lotensin (Novartis),
Injection-site reactions [5] Injection-site edema (20%) [12]
Lotensin HCT (Novartis), Micardis (Boehringer
Injection-site erythema (47%) [8]
Other Ingelheim), Microzide (Watson), Moduretic
Injection-site granuloma [2]
Adverse effects [2] (Merck), Prinzide (Merck), Tekturna HCT
Injection-site nodules [3]
(Novartis), Teveten HCT (Biovail), Uniretic
Injection-site pain (847%) [16]
(Schwarz), Vaseretic (Biovail), Zestoretic
Injection-site reactions (<11%) [12]
(AstraZeneca), Ziac (Barr)
HYALURONIC ACID Other Indications: Edema
Adverse effects [14] Class: Diuretic, thiazide
Synonym: hyaluronidase Infection [2] Half-life: 5.614.8 hours
Trade names: Euflexxa (Ferring), Hyalgan
(Sanofi-Aventis), Hylan G-F 20 (Synvisc),
interactions with: digoxin, dofetilide, lithium,
Juvederm (Allergan), Perlane (Q-Med AB),
Restylane Fine Lines (Medicis), Vitrase (ISTA HYDRALAZINE zinc
Pharma)
Trade names: Apresazide (Novartis), Apresoline Important contra-indications noted in the
Indications: Oral: joint disorders Injection:
(Novartis), Ser-Ap-Es (Novartis) prescribing guidelines for: nursing mothers;
adjunct in eye surgery, viscosupplementation in
Indications: Hypertension pediatric patients
orthopedics, cosmetic surgery Topical: wounds,
Class: Vasodilator Note: Hydrochlorothiazide is a sulfonamide and
burns, skin ulcers, stomatitis
Half-life: 37 hours can be absorbed systemically. Sulfonamides can
Class: Food supplement, Glycoaminoglycan
Clinically important, potentially hazardous produce severe, possibly fatal, reactions such as
Half-life: 2.55.5 minutes
interactions with: acebutolol, alfuzosin, toxic epidermal necrolysis and Stevens-Johnson
captopril, cilazapril, diclofenac, enalapril, syndrome.
interactions with: furosemide, local anesthetics,
fosinopril, levodopa, levomepromazine, lisinopril, Hydrochlorothiazide is often used in combination,
NSAIDs, oral anticoagulants
meloxicam, olmesartan, quinapril, ramipril, e.g. with aliskiren (Tekturna HCT); amiloride
trandolapril, triamcinolone, trifluoperazine, (Moduretic); benazepril (Lotensin HCT);
zuclopenthixol bisoprolol (Ziac); captopril (Capozide); enalapril
Pregnancy category: C (Vaseretic); irbesartan (Avalide); lisinopril
pediatric patients
Note: Apresazide is hydralazine and (Prinzide and Zestoretic); losartan (Hyzaar);
Note: Most reported reactions relate to
hydrochlorothiazide; Ser-Ap-Es is hydralazine, methyldopa (Aldoril); moexipril (Uniretic);
orthopedic use.
reserpine and hydrochlorothiazide. spironolactone (Aldactazide); triamterene
Hydrochlorothiazide is a sulfonamide and can be (Dyazide and Maxzide).
Skin absorbed systemically. Sulfonamides can produce
Acneform eruption (<29%) severe, possibly fatal, reactions such as toxic Skin
Anaphylactoid reactions/Anaphylaxis [2] epidermal necrolysis and Stevens-Johnson Dermatitis [2]
Angioedema [6] syndrome. Diaphoresis [2]
Churg-Strauss syndrome [12] Edema [2]
Dermatitis (24%) Erythema annulare centrifugum [2]
Ecchymoses [3] Skin
Edema [2] Lichenoid eruption [5]
Edema [8] Lupus erythematosus [16]
Erythema [6] Exanthems [4]
Lupus erythematosus (7%) [112] Peripheral edema [5]
Erythema multiforme [2] Photosensitivity [18]
Facial edema [2] Photosensitivity [2]
Purpura [3] Phototoxicity [5]
Granulomatous reaction [2] Purpura [6]
Hematoma [2] Sweet’s syndrome [6]
Toxic epidermal necrolysis [2] Rash [2]
Herpes simplex [2] Toxic epidermal necrolysis [2]
Hypersensitivity [6] Ulcerations [2]
Vasculitis [13] Vasculitis [3]
Induration [2]
HYDROCHLOROTHIAZIDE See all our books at www.crcpress.com
Cardiovascular Mucosal pegvisomant, pentazocine, phenothiazines,

Hypotension [5] Xerostomia (3%) sodium oxybate, SSRIs, St John’s wort,
Central Nervous System Cardiovascular succinylcholine, thiazide diuretics
Headache [7] Chest pain (<10%) Pregnancy category: C
Vertigo (dizziness) [8] Important contra-indications noted in the
Central Nervous System prescribing guidelines for: nursing mothers;
Neuromuscular/Skeletal Fever (<10%) pediatric patients
Asthenia (fatigue) [3] Headache [2] Note: OROS hydromorphone prolonged release
Gastrointestinal/Hepatic Migraine (<10%) (Jurnista) is a once-daily formulation of
Diarrhea [2] Paresthesias (<10%) hydromorphone that utilizes OROS (osmotic-
Nausea [2] Somnolence (drowsiness) (<5%) [3] controlled release oral delivery system)
Pancreatitis [4] Tremor (3%) technology to deliver the drug at a near constant
Vertigo (dizziness) (2–3%) [4] rate.
Respiratory
Neuromuscular/Skeletal Warning: ADDICTION, ABUSE, AND MISUSE;
Arthralgia (<10%) LIFE-THREATENING RESPIRATORY
Endocrine/Metabolic Asthenia (fatigue) (<4%) DEPRESSION; ACCIDENTAL INGESTION;
Hyponatremia [3] Back pain (<4%) [2] NEONATAL OPIOID WITHDRAWAL
Serum creatinine increased [2] Bone or joint pain (<10%) SYNDROME; and INTERACTION WITH
SIADH [4] Muscle spasm (<3%) ALCOHOL
Ocular Myalgia/Myopathy (<10%)
Glaucoma [2] Neck pain (<10%) Skin
Other Pain in extremities (<10%) Pruritus (<11%) [12]
Adverse effects [5] Gastrointestinal/Hepatic Mucosal
Death [2] Abdominal pain (2–3%) Xerostomia (<10%)
Constipation (8–11%) [7]
Gastroesophageal reflux (<10%) Cardiovascular
Nausea (7–10%) [9] Bradycardia [2]
HYDROCODONE Vomiting [8] Flushing (<10%)
Hypotension [2]
Trade names: Duratuss (UCB), Entex HC Respiratory
(Andrx), Hycotuss (Endo), Hydromet (Actavis), Cough (<10%) Central Nervous System
Dyspnea (<10%) Agitation [3]
Hysingla ER (Purdue), Lortab (UCB), Maxidone
Upper respiratory tract infection (<3%) Dysgeusia (taste perversion) [3]
(Watson), Norco (Watson), Tussionex (Celltech),
Headache [5]
Vicodin (AbbVie), Vicoprofen (AbbVie), Zohydro Endocrine/Metabolic Hyperalgesia [3]
ER (Pernix), Zydone (Endo) Dehydration (<10%) Somnolence (drowsiness) [6]
Indications: Acute pain, coughing GGT increased (<10%) Tremor [2]
Class: Opiate agonist Hypokalemia (<10%) Vertigo (dizziness) [10]
Clinically important, potentially hazardous Genitourinary Neuromuscular/Skeletal
interactions with: alcohol, buprenorphine, Urinary tract infection (<5%) Asthenia (fatigue) [5]
butorphanol, CYP3A4 inhibitors or inducers, Myoclonus [3]
MAO inhibitors, nalbuphine, pentazocine Gastrointestinal/Hepatic
Pregnancy category: C HYDROCORTISONE Constipation [10]
Important contra-indications noted in the Nausea [17]
prescribing guidelines for: nursing mothers; See: www.drugeruptiondata.com/drug/id/1103 Vomiting [11]
pediatric patients
Note: Hydrocodone is included in many Endocrine/Metabolic
combination drugs. Other medications that can
be included in these preparations include:
HYDROFLU- Other
phenylpropanolamine, phenylephrine, pyrilamine, METHIAZIDE Adverse effects [7]
pseudoephedrine, acetaminophen, ibuprofen, and
others. Zohydro ER is the first extended-release, See: www.drugeruptiondata.com/drug/id/344
single-entity hydrocodone-containing drug
product approved by the FDA and reflects the
HYDROQUINONE
newly updated labeling requirements recently
announced by the FDA.
HYDROMORPHONE Trade names: Ambi (Johnson & Johnson), Lustra
(Taro)
Warning: ADDICTION, ABUSE, AND MISUSE; Indications: Ultraviolet induced dyschromia and
Trade names: Dilaudid (AbbVie), Exalgo
LIFE-THREATENING RESPIRATORY discoloration resulting from the use of oral
(Mallinckrodt), Jurnista (Janssen-Cilag), Palladone
DEPRESSION; ACCIDENTAL INGESTION; contraceptives, pregnancy, hormone replacement
(Napp)
NEONATAL OPIOID WITHDRAWAL therapy, or skin trauma
Indications: Pain
SYNDROME; INTERACTION WITH Class: Depigmentation agent
Class: Opiate agonist
ALCOHOL; and CYTOCHROME P450 3A4 Half-life: N/A
Half-life: 1–3 hours; 2 hours (IV)
INTERACTION Clinically important, potentially hazardous
interactions with: alcohol, alvimopan, interactions with: none known
Skin ammonium chloride, amphetamines, Pregnancy category: C
Hot flashes (<10%) anticholinergics, anxiolytics and hypnotics, Important contra-indications noted in the
Hyperhidrosis (<10%) buprenorphine, butorphanol, cimetidine, CNS prescribing guidelines for: nursing mothers;
Peripheral edema (<3%) depressants, desmopressin, domperidone, pediatric patients
Pruritus (3%) [2] droperidol, linezolid, MAO inhibitors,
Rash (<10%) metoclopramide, moclobemide, nalbuphine,
Litt’s Drug Eruption & Reaction Manual HYDROXYZINE
Skin QT prolongation [3] Telangiectasia [2]

Acneform eruption [2] Central Nervous System Tumors [5]
Burning [2] Anorexia [2] Ulcerations [27]
Contact dermatitis (localized) [2] Dysgeusia (taste perversion) [2] Vasculitis [6]
Depigmentation [2] Headache [2] Xerosis (<10%) [7]
Erythema [4] Neurotoxicity [3] Hair
Ochronosis [15] Alopecia (<10%) [8]
Peeling [2] Neuromuscular/Skeletal
Pigmentation [3] Asthenia (fatigue) [3] Nails
Pruritus [2] Myalgia/Myopathy [8] Atrophic nails [3]
Scaling [2] Gastrointestinal/Hepatic Melanonychia [7]
Striae [2] Diarrhea [5] Nail changes [4]
Xerosis [2] Dysphagia [2] Nail dystrophy [2]
Nausea [6] Nail pigmentation [18]
Other Onycholysis [2]
Adverse effects [3] Vomiting [4]
Endocrine/Metabolic Mucosal
Hypoglycemia [3] Oral lesions [2]
Porphyria [7] Oral pigmentation [2]
HYDROXY- Weight loss [2] Oral squamous cell carcinoma [2]
Oral ulceration [8]
CHLOROQUINE Hematologic Stomatitis (>10%) [4]
Anemia [3] Tongue pigmentation (<29%) [3]
Trade name: Plaquenil (Sanofi-Aventis) Neutropenia [2]
Indications: Malaria, lupus erythematosus, Thrombocytopenia [4] Gastrointestinal/Hepatic
rheumatoid arthritis Pancreatitis [2]
Class: Antimalarial, Antiprotozoal, Disease-
Otic
Hearing loss [2] Other
modifying antirheumatic drug (DMARD) Adverse effects [2]
Half-life: 32–50 days Ocular Death [2]
Clinically important, potentially hazardous Maculopathy [5] Side effects (735%) [3]
interactions with: chloroquine, cholestyramine, Ocular adverse effects [2]
dapsone, droperidol, ethosuximide, lacosamide, Ocular toxicity [9]
lanthanum, moxifloxacin, neostigmine, Reduced visual acuity [2]
oxcarbazepine, penicillamine, tiagabine, typhoid Retinopathy [29] HYDROXYZINE
vaccine, vigabatrin, yellow fever vaccine Vision blurred [3]
Trade names: Atarax (Pfizer), Vistaril (Pfizer)
Pregnancy category: C Other Indications: Anxiety and tension, pruritus
Important contra-indications noted in the Adverse effects [8] Class: Histamine H1 receptor antagonist,
prescribing guidelines for: nursing mothers; Death [3] Muscarinic antagonist
pediatric patients
Half-life: 37 hours
Skin
AGEP [22]
HYDROXYUREA interactions with: alcohol, barbiturates, CNS
depressants, efavirenz, lurasidone, narcotics, non-
Bullous dermatitis [2] Synonym: hydroxycarbamide narcotic analgesics
DRESS syndrome [2] Trade names: Droxia (Bristol-Myers Squibb), Pregnancy category: C
Erythema annulare centrifugum [3] Hydrea (Bristol-Myers Squibb) Important contra-indications noted in the
Erythema multiforme [2] Indications: Leukemia, malignant tumors prescribing guidelines for: nursing mothers
Erythroderma [3] Class: Antineoplastic, Antiretroviral
Exanthems (<5%) [4] Half-life: 34 hours
Skin
Lichenoid eruption [4] interactions with: adefovir, aldesleukin Anaphylactoid reactions/Anaphylaxis [2]
Photosensitivity [6] Pregnancy category: D Angioedema [3]
Phototoxicity [3]
Pigmentation (<10%) [19]
Pruritus (>10%) [13] Skin Exanthems [3]
Psoriasis (exacerbation) [13] Acral erythema [8] Fixed eruption [3]
Rash (<10%) [4] Atrophy [4] Urticaria [4]
Thrombocytopenic purpura [2] Dermatitis [3] Mucosal
Toxic epidermal necrolysis [3] Dermatomyositis [28] Xerostomia (12%) [4]
Urticaria [2] Exanthems (<10%)
Fixed eruption [4] Central Nervous System
Hair Ichthyosis [2] Somnolence (drowsiness) [5]
Alopecia [2] Keratoses [2] Gastrointestinal/Hepatic
Hair pigmentation (bleaching) (<10%) [8] Leg ulceration (29%) [20] Vomiting [2]
Nails Lichen planus [3]
Nail pigmentation [3] Lichenoid eruption [3]
Mucosal Lupus erythematosus [3]
Oral pigmentation [7] Palmar–plantar desquamation [6]
Stomatitis [2] Pigmentation (<58%) [17]
Poikiloderma [3]
Cardiovascular Pruritus [3]
Cardiomyopathy [8] Purpura [2]
Cardiotoxicity [4] Radiation recall dermatitis [2]
HYOSCYAMINE Over 100 updates per week on www.drugeruptiondata.com
Pregnancy category: C Local

HYOSCYAMINE Important contra-indications noted in the Injection-site inflammation (>10%)
Trade names: IB-Stat (InKline), Levbid mothers; pediatric patients
(Schwarz), Levsin (Schwarz), Levsin/SL
(Schwarz), Levsinex (Schwarz), Nulev (Schwarz)
Indications: Treatment of gastrointestinal tract Skin
disorders caused by spasm, adjunctive therapy for Photosensitivity (<10%)
peptic ulcers, cystitis, Parkinsonism, biliary and Xerosis (>10%)
renal colic Mucosal
Class: Anticholinergic, Muscarinic antagonist Xerostomia (>10%)
Half-life: N/A Cardiovascular
Clinically important, potentially hazardous Tachycardia [2]
interactions with: anticholinergics, arbutamine
Litt’s Drug Eruption & Reaction Manual IBUPROFEN
Cytopenia [3]
IBANDRONATE IBRUTINIB Febrile neutropenia [3]
Hemorrhage [2]
Synonym: ibandronic acid Trade name: Imbruvica (Pharmacyclics) Lymphocytosis [2]
Trade names: Bondronat (Roche), Boniva Indications: Mantle cell lymphoma Neutropenia [15]
(Roche) Class: Bruton’s tyrosine kinase (BTK) inhibitor Sepsis [2]
Indications: Postmenopausal osteoporosis Half-life: 4–6 hours Thrombocytopenia [13]
Class: Bisphosphonate Clinically important, potentially hazardous
Half-life: 37–157 hours interactions with: carbamazepine, Other
Clinically important, potentially hazardous clarithromycin, grapefruit juice, itraconazole, Adverse effects [2]
interactions with: alcohol, aminoglycosides, ketoconazole, phenytoin, posaconazole, rifampin, Infection [7]
antacids, calcium salts, food, magnesium salts, St John’s wort, strong or moderate CYP3A
NSAIDs, oral iron inhibitors or inducers, telithromycin, voriconazole
Pregnancy category: C Pregnancy category: D IBUPROFEN
prescribing guidelines for: nursing mothers; prescribing guidelines for: nursing mothers; Trade names: Advil (Wyeth), Motrin (McNeil),
pediatric patients pediatric patients Vicoprofen (AbbVie)
Indications: Arthritis, pain
Skin Skin Class: Non-steroidal anti-inflammatory (NSAID)
Rash (<2%) Cellulitis [3] Half-life: 24 hours
Ecchymoses (30%) [4] Clinically important, potentially hazardous
Cardiovascular interactions with: aspirin, ciprofibrate, diuretics,
Hypertension (6–7%) Panniculitis [2]
Peripheral edema (35%) [3] methotrexate, methyl salicylate, NSAIDs,
Central Nervous System Petechiae (11%) oxycodone hydrochloride, salicylates, tacrine,
Fever (~9%) [4] Rash (25%) [5] tacrolimus, urokinase, voriconazole
Headache (3–7%) Toxicity (14%) [3] Pregnancy category: D (category C prior to 30
Vertigo (dizziness) (<4%) Tumor lysis syndrome [2] weeks gestation; category D starting at 30 weeks
gestation)
Neuromuscular/Skeletal Mucosal Note: NSAIDs may cause an increased risk of
Arthralgia (3–6%) [2] Epistaxis (nosebleed) (11%) serious cardiovascular and gastrointestinal
Asthenia (fatigue) (4%) [3] Stomatitis (17%) adverse events, which can be fatal. This risk may
Back pain (4–14%)
Cardiovascular increase with duration of use.
Bone or joint pain [3]
Cramps (2%) Atrial fibrillation [10]
Joint disorder (4%) Hypertension [4] Skin
Myalgia/Myopathy (<6%) Hypotension [2] AGEP [5]
Osteonecrosis [13] Central Nervous System Anaphylactoid reactions/Anaphylaxis [5]
Pain in extremities (<8%) Fever (18%) [5] Angioedema [8]
Headache (13%) [2] Bullous dermatitis [3]
Peripheral neuropathy [2] Bullous pemphigoid [2]
Vertigo (dizziness) (14%) Dermatitis [5]
Constipation (3–4%)
Neuromuscular/Skeletal DRESS syndrome [4]
Dyspepsia (6–12%) [4] Arthralgia (11%) [3]
Erythema nodosum (<5%)
Gastritis (2%) Asthenia (fatigue) (14–41%) [19]
Exanthems [9]
Gastrointestinal disorder [3] Bone or joint pain (37%)
Fixed eruption [15]
Nausea (5%) [4] Muscle spasm (14%) [2]
Vomiting (3%) [4] Gastrointestinal/Hepatic Lupus erythematosus [5]
Respiratory Abdominal pain (24%) Nicolau syndrome [2]
Bronchitis (3–10%) Constipation (25%) Peripheral edema [2]
Flu-like syndrome (<4%) [7] Diarrhea (51%) [23] Photosensitivity [6]
Nasopharyngitis (4%) Dyspepsia (11%) Pruritus (<5%) [5]
Pharyngitis (3%) Hepatotoxicity [2] Psoriasis (palms) [2]
Pneumonia (6%) Nausea (31%) [14] Rash (>10%) [2]
Upper respiratory tract infection (2–34%) Vomiting (24%) [3] Stevens-Johnson syndrome [10]
Endocrine/Metabolic Respiratory Toxic epidermal necrolysis [8]
Hypercholesterolemia (5%) Cough (19%) [3] Urticaria (>10%) [10]
Hypocalcemia [3] Dyspnea (27%) Vasculitis [8]
Hypophosphatemia [2] Pneumonia (14%) [7] Vesiculobullous eruption [2]
Genitourinary Sinusitis (13%) [2] Hair
Urinary tract infection (2–6%) Upper respiratory tract infection (34%) [6] Alopecia [2]
Other Endocrine/Metabolic Cardiovascular
Adverse effects [5] Appetite decreased (21%) Cardiotoxicity [2]
Allergic reactions (3%) Dehydration (12%) [2] Hypertension [4]
Infection (4%) Hyperuricemia (15%)
Hypokalemia [2]
Tooth disorder (4%) Aseptic meningitis [16]
Genitourinary Headache [3]
Urinary tract infection (14%) [2]
IBRITUMOMAB Hematologic Arthralgia [2]
Anemia [11] Back pain [2]
See: www.drugeruptiondata.com/drug/id/906 Bleeding [11]
IBUPROFEN See all our books at www.crcpress.com
Rhabdomyolysis [3] Central Nervous System

ICATIBANT Delirium (7%)
Abdominal pain [6] Fever (6%)
See: www.drugeruptiondata.com/drug/id/1368 Headache [2]
Constipation [4]
Diarrhea [4] Neuromuscular/Skeletal
Dyspepsia [5] Back pain [2]
Gastroesophageal reflux [2] ICODEXTRIN Gastrointestinal/Hepatic
Gastrointestinal bleeding [2] Constipation (7%)
Gastrointestinal disorder [2] See: www.drugeruptiondata.com/drug/id/1072
Hepatotoxicity [3] Respiratory
Nausea [7] Nasopharyngitis [2]
Pancreatitis [2] IDARUBICIN Pneumonia (6%)
Vanishing bile duct syndrome [2] Endocrine/Metabolic
Vomiting [5] Synonyms: 4-demethoxydaunorubicin; 4-DMDR Hypokalemia (7%)
Respiratory Trade name: Idamycin (Pfizer)
Influenza [2] Indications: Acute myeloid leukemia
Sinusitis [2]
Half-life: 1435 hours (oral)
IDEBENONE
Endocrine/Metabolic interactions with: aldesleukin
Pseudoporphyria [2] Pregnancy category: D
Genitourinary Important contra-indications noted in the
Urinary tract infection [2] prescribing guidelines for: nursing mothers; IDELALISIB
Renal pediatric patients
Trade name: Zydelig (Gilead)
Nephrotoxicity [4] Indications: Relapsed chronic lymphocytic
Hematologic Skin leukemia (with rituximab), follicular B-cell non-
Thrombocytopenia [5] Rash (>10%) [4] Hodgkin lymphoma, small lymphocytic lymphoma
Urticaria (>10%) Class: Phosphoinositide 3-kinase (PI3K) inhibitor
Otic
Hearing loss [2] Hair Half-life: 8 hours
Tinnitus [2] Alopecia (77%) [8] Clinically important, potentially hazardous
Mucosal interactions with: carbamazepine, copanlisib,
Ocular midostaurin, neratinib, phenytoin, rifampin, St
Amblyopia [2] Mucositis (50%) [5]
Stomatitis (>10%) John’s wort, strong CYP3A inducers and
Optic neuritis [2] substrates
Periorbital edema [3] Gastrointestinal/Hepatic Pregnancy category: D
Visual disturbances [2] Diarrhea [3] Important contra-indications noted in the
Other Hepatotoxicity [2] prescribing guidelines for: nursing mothers;
Adverse effects [13] Nausea [2] pediatric patients
Kounis syndrome [3] Vomiting [2] Warning: FATAL AND SERIOUS TOXICITIES:
Hematologic HEPATIC, SEVERE DIARRHEA, COLITIS,
Febrile neutropenia [2] PNEUMONITIS, and INTESTINAL
IBUTILIDE Neutropenia [2] PERFORATION
Other
Trade name: Corvert (Pfizer) Infection [2] Skin
Indications: Atrial fibrillation and flutter Diaphoresis (12%)
Class: Antiarrhythmic, Antiarrhythmic class III Peripheral edema (10%)
Half-life: 212 hours IDARUCIZUMAB Rash (21%) [7]
Clinically important, potentially hazardous Toxicity [2]
interactions with: degarelix Trade name: Praxbind (Boehringer Ingelheim) Central Nervous System
Pregnancy category: C Indications: Reversal of the anticoagulant effects Chills [5]
Important contra-indications noted in the of dabigatran in patients requiring emergency or Fever [9]
prescribing guidelines for: nursing mothers; urgent surgery or with life-threatening or Headache (11%)
pediatric patients uncontrolled bleeding Insomnia (12%)
Class: Monoclonal antibody, Reversal agent for Neuromuscular/Skeletal
Cardiovascular dabigatran Asthenia (fatigue) (30%) [8]
Bradycardia [4] Half-life: 10 hours
Hypotension [2] Clinically important, potentially hazardous Gastrointestinal/Hepatic
QT prolongation [5] interactions with: none known Abdominal pain (26%)
Tachycardia (3%) Pregnancy category: N/A (No data available) Colitis [6]
Torsades de pointes [10] Important contra-indications noted in the Constipation [2]
Ventricular arrhythmia [4] prescribing guidelines for: nursing mothers; Diarrhea (47%) [15]
Ventricular tachycardia [6] pediatric patients Gastrointestinal perforation [2]
Note: Risk of serious adverse reactions in Hepatotoxicity [8]
Central Nervous System Nausea (29%) [8]
Headache (4%) patients with hereditary fructose intolerance due
to sorbitol excipient. Vomiting (15%) [3]
Nausea (2%) [3] Cough (29%) [5]
Skin
Irritation [2] Dyspnea (17%)
Pneumonia (25%) [9]
Litt’s Drug Eruption & Reaction Manual IMATINIB
Pneumonitis [5] Thrombocytopenia [4]

Upper respiratory tract infection (12%) [3] Other
IMATINIB
Endocrine/Metabolic Allergic reactions (<10%) Trade name: Gleevec (Novartis)
ALT increased (50%) [8] Death [2] Indications: Chronic myeloid leukemia
Appetite decreased (16%) [2] Infection [2] Class: Antineoplastic, Biologic, CYP3A4 inhibitor,
AST increased (41%) [8] Tyrosine kinase inhibitor
Hematologic Half-life: 18 hours
Anemia [6] ILOPERIDONE Clinically important, potentially hazardous
Febrile neutropenia [6] interactions with: acetaminophen, amlodipine,
Neutropenia [8] Trade name: Fanapt (Vanda) anisindione, anticoagulants, aprepitant,
Thrombocytopenia [6] Indications: Schizophrenia atorvastatin, barbiturates, benzodiazepines,
Other Class: Antipsychotic butabarbital, carbamazepine, chlordiazepoxide,
Adverse effects [2] Half-life: 18–33 hours clarithromycin, clonazepam, clorazepate,
Side effects [2] Clinically important, potentially hazardous corticosteroids, cyclosporine, dexamethasone,
interactions with: alcohol, dextromethorphan, diazepam, dicumarol, efavirenz, erythromycin,
fluoxetine, itraconazole, ketoconazole, ethotoin, felodipine, flurazepam, fluvastatin,
paroxetine hydrochloride, QT prolonging agents fosphenytoin, isradipine, itraconazole,
IDURSULFASE Pregnancy category: C ketoconazole, lorazepam, lovastatin,
Important contra-indications noted in the mephenytoin, mephobarbital, midazolam,
See: www.drugeruptiondata.com/drug/id/1185 prescribing guidelines for: the elderly; nursing mifepristone, neratinib, nicardipine, nifedipine,
mothers; pediatric patients nimodipine, nisoldipine, olaparib, oxazepam,
Warning: INCREASED MORTALITY IN oxcarbazepine, pentobarbital, phenobarbital,
IFOSFAMIDE ELDERLY PATIENTS WITH DEMENTIA- phenytoin, pimozide, pravastatin, primidone,
RELATED PSYCHOSIS quazepam, rifampin, rifapentine, safinamide,
Trade name: Ifex (Bristol-Myers Squibb) secobarbital, simvastatin, St John’s wort,
Indications: Cancers, sarcomas, leukemias, Skin temazepam, voriconazole, warfarin
lymphomas Rash (2%) Pregnancy category: D
Class: Alkylating agent Important contra-indications noted in the
Half-life: 415 hours Mucosal prescribing guidelines for: nursing mothers
Clinically important, potentially hazardous Nasal congestion (8%) [2]
interactions with: aldesleukin, aprepitant Xerostomia (10%) [9]
Skin
Pregnancy category: D Cardiovascular Acneform eruption [2]
Hypotension (3%) AGEP [7]
Skin Orthostatic hypotension (3%) [4] Diaphoresis (13%)
Dermatitis (<10%) QT prolongation [8] DRESS syndrome [3]
Pigmentation (<10%) [2] Tachycardia (12%) [4] Edema (<5%) [35]
Toxicity [2] Central Nervous System Erythema (<10%) [5]
Hair Akathisia (2%) [3] Erythema multiforme [2]
Alopecia (50100%) [4] Anxiety [2] Erythroderma [3]
Headache [3] Exanthems [9]
Nails Insomnia (18%) [3] Exfoliative dermatitis [4]
Ridging (<10%) Sedation [3] Facial edema (<10%) [3]
Cardiovascular Somnolence (drowsiness) (15%) [8] Hand–foot syndrome [3]
Phlebitis (2%) Tremor (3%) Hypomelanosis [5]
Central Nervous System Vertigo (dizziness) (20%) [11] Lichen planus [5]
Confusion [2] Neuromuscular/Skeletal Lichenoid eruption [11]
Delirium [2] Arthralgia (3%) Mycosis fungoides [2]
Encephalopathy [10] Asthenia (fatigue) (6%) [2] Neutrophilic eccrine hidradenitis [3]
Neurotoxicity [11] Panniculitis [3]
Gastrointestinal/Hepatic Peripheral edema (<10%) [5]
Seizures [2] Diarrhea (7%) Petechiae (<10%)
Neuromuscular/Skeletal Dyspepsia [3] Photosensitivity (<10%) [3]
Osteomalacia [2] Nausea (10%) [2] Pigmentation [12]
Gastrointestinal/Hepatic Respiratory Pityriasis rosea [5]
Hepatotoxicity [2] Dyspnea (2%) Pruritus (6–10%) [3]
Nausea [6] Nasopharyngitis (3%) Pseudolymphoma [3]
Pancreatitis [2] Upper respiratory tract infection (3%) Psoriasis [3]
Vomiting [6] Endocrine/Metabolic Rash (32–39%) [26]
Endocrine/Metabolic Weight gain (9%) [10] Squamous cell carcinoma [2]
SIADH [2] Genitourinary Sweet’s syndrome [3]
Renal Ejaculatory dysfunction (2%) [2] Toxicity [9]
Fanconi syndrome [4] Urticaria [3]
Nephrotoxicity [34] Vasculitis [2]
Hematologic ILOPROST Xerosis (<10%) [2]
Anemia [3] Hair
Febrile neutropenia [2] See: www.drugeruptiondata.com/drug/id/1132 Alopecia (10–15%) [2]
Leukopenia [2] Follicular mucinosis [2]
Myelosuppression [2]
Neutropenia [4]
IMATINIB Over 100 updates per week on www.drugeruptiondata.com
Nails Otic Cardiovascular

Nail dystrophy [2] Hearing loss [4] QT prolongation [3]
Mucosal Ocular Tachycardia [2]
Mucositis [2] Epiphora (25%) Central Nervous System
Oral lichenoid eruption [3] Eyelid edema [2] Dysgeusia (taste perversion) (metallic taste)
Oral pigmentation [3] Optic edema [2] (>10%) [2]
Oral ulceration [3] Periorbital edema (33%) [11] Parkinsonism (<10%)
Cardiovascular Other Neuromuscular/Skeletal
Cardiotoxicity [2] Adverse effects [14] Asthenia (fatigue) [2]
Congestive heart failure [2] Death [3] Endocrine/Metabolic
QT prolongation [2] Side effects [2] SIADH [4]
Central Nervous System Otic
Anorexia [4] Tinnitus [4]
Chills (11%) IMIDAPRIL
Depression (15%) [2]
Fever (13–41%) [2] See: www.drugeruptiondata.com/drug/id/1265
Headache (19–37%) [4] IMIQUIMOD
Hypoesthesia (<10%)
Trade names: Aldara (3M), Zyclara (Graceway)
Insomnia (10–19%)
Subdural hemorrhage [2]
IMIGLUCERASE Indications: External genital and perianal warts,
Vertigo (dizziness) [2] actinic keratoses
See: www.drugeruptiondata.com/drug/id/1028 Class: Antiviral, Immunomodulator
Neuromuscular/Skeletal Half-life: N/A
Arthralgia (21–26%) [4] Clinically important, potentially hazardous
Bone or joint pain (11–31%) [13]
IMIPENEM/CILASTATIN interactions with: none known
Muscle spasm [9] See: www.drugeruptiondata.com/drug/id/353 Important contra-indications noted in the
Myalgia/Myopathy (16–62%) [11] prescribing guidelines for: nursing mothers;
Osteonecrosis [3] pediatric patients
Abdominal pain [5]
IMIPRAMINE
Skin
Ascites [2] Trade name: Tofranil (Mallinckrodt) Angioedema [2]
Constipation (9–16%) [2] Indications: Depression Burning (931%) [7]
Diarrhea (25–59%) [17] Class: Antidepressant, tricyclic, Muscarinic Crusting [3]
Dyspepsia [2] antagonist Depigmentation [3]
Gastrointestinal bleeding [5] Half-life: 618 hours Eczema (<10%)
Hepatotoxicity (6–12%) [18] Clinically important, potentially hazardous Edema (1217%) [2]
Nausea (42–73%) [15] interactions with: amprenavir, arbutamine, Erosions (1032%) [5]
Vomiting (23–58%) [13] artemether/lumefantrine, clonidine, cobicistat/ Erythema (3385%) [14]
Respiratory elvitegravir/emtricitabine/tenofovir alafenamide, Erythema multiforme [2]
Cough (11–27%) cobicistat/elvitegravir/emtricitabine/tenofovir Excoriations (1825%) [2]
Dyspnea (21%) disoproxil, darifenacin, epinephrine, fluoxetine, Flaking (1867%) [3]
Nasopharyngitis (10–31%) formoterol, guanethidine, iobenguane, Fungal dermatitis (<10%)
Pharyngitis (10–15%) isocarboxazid, labetalol, linezolid, MAO Herpes simplex (<10%)
Pleural effusion [3] inhibitors, phenelzine, propranolol, quinolones, Hypomelanosis [2]
Pneumonitis (4–13%) [2] ropivacaine, sparfloxacin, tranylcypromine, Induration (5%)
Pulmonary toxicity [2] zaleplon, zolpidem Lichen planus [3]
Rhinitis (17%) Pregnancy category: D Lupus erythematosus [3]
Upper respiratory tract infection (3–21%) Warning: SUICIDALITY AND Lymphadenopathy (2%)
Endocrine/Metabolic ANTIDEPRESSANT DRUGS Pemphigus [4]
Creatine phosphokinase increased [2] Pemphigus foliaceus [3]
Gynecomastia [4] Skin Pigmentation [3]
Hypophosphatemia [2] Diaphoresis (<25%) [8] Pruritus (2275%) [10]
Hypothyroidism [2] Exanthems (<6%) [6] Psoriasis [3]
Porphyria cutanea tarda [3] Exfoliative dermatitis [4] Scabbing (4%)
Pseudoporphyria [5] Photosensitivity [3] Scar [3]
Weight gain (5–32%) [3] Pigmentation [13] Seborrheic keratoses (<10%)
Pruritus (3%) [6] Tenderness (local) (12%) [2]
Renal Ulcerations (510%) [5]
Fanconi syndrome [2] Purpura [3]
Urticaria [6] Vesiculation (23%)
Nephrotoxicity [2] Vitiligo [7]
Renal failure [2] Hair
Alopecia [2] Hair
Hematologic Alopecia (<10%)
Anemia [10] Mucosal Poliosis [2]
Febrile neutropenia [2] Glossitis [2]
Hemotoxicity [4] Oral lesions [3] Cardiovascular
Leukopenia [3] Stomatitis [2] Chest pain (<10%)
Myelosuppression [2] Xerostomia (>10%) [16] Central Nervous System
Neutropenia [13] Anorexia (<10%)
Thrombocytopenia [11] Anxiety (<10%)
Litt’s Drug Eruption & Reaction Manual INDACATEROL
Fever (<10%) [2] Myocardial infarction [2] Respiratory

Headache (<10%) [3] Palpitation [2] Bronchitis [2]
Neurotoxicity [2] Thromboembolism [3] Cough (10%)
Pain (211%) [6] Central Nervous System Upper respiratory tract infection [2]
Rigors (<10%) Aseptic meningitis [6] Local
Vertigo (dizziness) (<10%) Chills [4] Injection-site reactions (49–92%) [5]
Neuromuscular/Skeletal Fever [10] Other
Asthenia (fatigue) (<10%) [2] Headache [16] Allergic reactions (11%)
Back pain (<10%) Neuromuscular/Skeletal
Myalgia/Myopathy (<10%) Arthralgia [2]
Gastrointestinal/Hepatic Asthenia (fatigue) [3]
INACTIVATED POLIO
Nausea (<10%) [2] Myalgia/Myopathy [3]
Vomiting (<10%) Gastrointestinal/Hepatic VACCINE
Respiratory Abdominal pain [2]
Cough (<10%) Diarrhea [2] See: www.drugeruptiondata.com/drug/id/1408
Flu-like syndrome (<3%) Nausea [8]
Pharyngitis (<10%) Vomiting [2]
Rhinitis (<10%) Respiratory INAMRINONE
Sinusitis (<10%) Cough [2]
Upper respiratory tract infection (<10%) Dyspnea [2] See: www.drugeruptiondata.com/drug/id/355
Genitourinary Pulmonary embolism [2]
Urinary tract infection (<10%) Renal
Local Nephrotoxicity [6] INDACATEROL
Application-site burning (<10%) Renal failure [2]
Application-site edema (<10%) [4] Trade names: Arcapta Neohaler (Novartis),
Hematologic Onbrez Breezhaler (Novartis), Utibron Neohaler
Application-site erythema (<10%) [3] Anemia [2]
Application-site pruritus (<10%) [4] (Novartis)
Hemolysis [2]
Application-site reactions [9] Indications: Long term, once-daily maintenance
Hemolytic anemia [3]
bronchodilator treatment of airflow obstruction
Other Thrombosis [3]
in chronic obstructive pulmonary disease
Adverse effects [6] Local (COPD), including chronic bronchitis and/or
Application-site pain (16%) emphysema
Infusion-related reactions [4] Class: Beta-2 adrenergic agonist, Bronchodilator
IMMUNE GLOBULIN Injection-site edema [2] Half-life: 40–56 hours
Injection-site erythema [2] Clinically important, potentially hazardous
(EQUINE) Other interactions with: acetazolamide, adrenergics,
Adverse effects [9] aminophylline, arsenic, corticosteroids, diuretics,
See: www.drugeruptiondata.com/drug/id/2597 erythromycin, ketoconazole, MAO inhibitors,
pazopanib, QT prolonging agents, ritonavir,
steroids, telavancin, theophylline, tricyclic
IMMUNE GLOBULIN IV IMMUNE GLOBULIN SC antidepressants, verapamil, xanthine derivatives
Synonyms: IGIV; IVIG Synonym: SCIG Important contra-indications noted in the
Trade names: Gamimune (Bayer), Gammagard Trade names: Cuvitru (Shire), Hizentra (CSL prescribing guidelines for: nursing mothers;
(Baxter), Gammar PIV (ZLB Behring), Gamunex Behring), Vivaglobin (CSL Behring) pediatric patients
(Bayer), Iveegam (Baxter), Venoglobulin (Alpha Indications: Primary immune deficiency Note: Studies in asthma patients showed that
Therapeutics) Class: Immunomodulator long-acting beta2-adrenergic agonists may
Indications: Immunodeficiency in patients unable Half-life: N/A increase the risk of asthma-related death.
to produce sufficient amounts of IgG antibodies Clinically important, potentially hazardous Contra-indicated in patients with asthma without
Class: Immunomodulator interactions with: none known use of a long-term asthma control medication.
Half-life: N/A Pregnancy category: C Utibron Neohaler is indacaterol and
Warning: THROMBOSIS glycopyrrolate.
interactions with: live vaccines Warning: ASTHMA-RELATED DEATH
Important contra-indications noted in the Pruritus [2] Mucosal
prescribing guidelines for: nursing mothers Rash (<3%) Oropharyngeal pain [2]
Warning: THROMBOSIS, RENAL Mucosal
DYSFUNCTION and ACUTE RENAL FAILURE Central Nervous System
Oropharyngeal pain (17%) Headache (5%) [3]
Cardiovascular Pain (oropharyngeal) (2%)
Skin Tachycardia (<3%)
Anaphylactoid reactions/Anaphylaxis [3] Gastrointestinal/Hepatic
Eczema [3] Central Nervous System Nausea (2%)
Lichenoid eruption [2] Fever (<3%) [2] Respiratory
Pompholyx [3] Headache (2–32%) [3] Asthma [2]
Rash [2] Neuromuscular/Skeletal COPD (exacerbation) [7]
Vasculitis [4] Asthenia (fatigue) (<5%) Cough (7%) [9]
Cardiovascular Gastrointestinal/Hepatic Dyspnea [2]
Flushing [2] Gastrointestinal disorder (<5%) Influenza [2]
Hypertension [3] Nausea (<11%) Nasopharyngitis (5%) [6]
INDACATEROL See all our books at www.crcpress.com
Upper respiratory tract infection [3] delavirdine, diazepam, didanosine, dienogest, Gingivitis (<2%)
Other digoxin, dihydroergotamine, dronedarone, Cardiovascular
Adverse effects [6] dutasteride, efavirenz, enfuvirtide, eplerenone, Flushing (<2%)
ergot derivatives, ergotamine, estazolam,
estrogens, etravirine, everolimus, felodipine, Central Nervous System
fentanyl, fesoterodine, flibanserin, flurazepam, Anorexia (3%)
INDAPAMIDE fluticasone propionate, food, fusidic acid, Dysesthesia (<2%)
grapefruit juice, guanfacine, H2-antagonists, Dysgeusia (taste perversion) (3%)
Trade name: Lozol (Sanofi-Aventis) halazepam, halofantrine, HMG-CoA reductase Fever (2%)
Indications: Edema inhibitors, itraconazole, ixabepilone, Headache (5%)
Class: Diuretic, thiazide ketoconazole, lapatinib, lidocaine, lomitapide, Hyperesthesia (<2%)
Half-life: 1418 hours lopinavir, lovastatin, maraviroc, meperidine, Paresthesias (<2%)
Clinically important, potentially hazardous methylergonovine, methylprednisolone, Somnolence (drowsiness) (2%)
interactions with: digoxin, lithium, zinc methysergide, midazolam, midostaurin, Vertigo (dizziness) (3%)
Pregnancy category: B mifepristone, mometasone, nefazodone, Neuromuscular/Skeletal
Important contra-indications noted in the nelfinavir, neratinib, nevirapine, nicardipine, Asthenia (fatigue) (2%)
prescribing guidelines for: the elderly; nursing nifedipine, nilotinib, nisoldipine, olaparib, P- Back pain (8%)
mothers; pediatric patients glycoprotein inhibitors and inducers, paclitaxel, Myalgia/Myopathy with lovastatin or
Note: Indapamide is a sulfonamide and can be palbociclib, pantoprazole, paricalcitol, pazopanib, simvastatin (<2%)
absorbed systemically. Sulfonamides can produce PEG-interferon, phenobarbital, phenytoin,
severe, possibly fatal, reactions such as toxic Gastrointestinal/Hepatic
pimavanserin, pimecrolimus, pimozide, ponatinib, Abdominal pain (17%) [2]
epidermal necrolysis and Stevens-Johnson prasugrel, protease inhibitors, proton pump
syndrome. Diarrhea (3%)
inhibitors, quazepam, quinidine, quinine, Dyspepsia (2%)
ranolazine, ribociclib, rifabutin, rifampin, Nausea (12%)
Skin rifapentine, rilpivirine, rivaroxaban, romidepsin, Vomiting (8%)
Angioedema [3] rosuvastatin, ruxolitinib, salmeterol, saxagliptin,
Erythema multiforme [2] sildenafil, silodosin, simeprevir, simvastatin, Respiratory
Pemphigus foliaceus [2] sirolimus, solifenacin, sorafenib, St John’s wort, Cough (2%)
Peripheral edema (<5%) [2] sunitinib, tacrolimus, tadalafil, tamsulosin, Endocrine/Metabolic
Pruritus (<5%) [2] telithromycin, temsirolimus, tenofovir disoproxil, ALT increased (5%)
Rash (<5%) [4] theophylline, ticagrelor, tolvaptan, trazodone, Appetite increased (2%)
Toxic epidermal necrolysis [3] triazolam, tricyclic antidepressants, valproic acid, AST increased (4%)
Urticaria (<5%) vardenafil, vemurafenib, venetoclax, venlafaxine, Creatine phosphokinase increased [2]
Vasculitis (<5%) vorapaxar, zidovudine Diabetes mellitus [2]
Mucosal Pregnancy category: C Gynecomastia [4]
Xerostomia (<5%) [2] Important contra-indications noted in the Porphyria (acute) [2]
Cardiovascular Genitourinary
pediatric patients
Flushing (<5%) Crystalluria [2]
Note: Protease inhibitors cause dyslipidemia
QT prolongation [5] Dysuria (2%)
which includes elevated triglycerides and
Central Nervous System cholesterol and redistribution of body fat centrally Renal
Paresthesias (<5%) to produce the so-called ‘protease paunch’, Nephrolithiasis (9%) [4]
Vertigo (dizziness) [2] breast enlargement, facial atrophy, and ‘buffalo Nephrotoxicity [13]
hump’. Ocular
Endocrine/Metabolic
Hypokalemia [2] Eyelid edema (<2%)
Hyponatremia [2] Skin Other
Bromhidrosis (<2%) Bruxism (<2%)
Dermatitis (<2%)
Diaphoresis (<2%)
INDINAVIR Folliculitis (<2%)
Herpes simplex (<2%) INDOMETHACIN
Trade name: Crixivan (Merck)
Indications: HIV infection
Herpes zoster (<2%)
Synonym: indometacin
Class: Antiretroviral, CYP3A4 inhibitor, HIV-1
Jaundice (2%)
Indications: Arthritis
protease inhibitor
Lipodystrophy [8]
Class: Non-steroidal anti-inflammatory (NSAID)
Half-life: ~1.8 hours
Lipomatosis [2]
Pruritus [2]
interactions with: abiraterone, alfuzosin,
Rash [2]
interactions with: aldesleukin, aspirin, atenolol,
almotriptan, alosetron, alprazolam, amiodarone,
Seborrhea (<2%)
cyclopenthiazide, diflunisal, diuretics,
amprenavir, antacids, antiarrhythmics, antifungal
methotrexate, NSAIDs, prednisolone,
agents, artemether/lumefantrine, astemizole,
Xerosis [2]
prednisone, sermorelin, tiludronate, torsemide,
atazanavir, atorvastatin, atovaquone, atovaquone/ Hair triamterene, urokinase
proguanil, avanafil, bepridil, bortezomib, Alopecia [5] Pregnancy category: C
bosentan, brigatinib, brinzolamide, cabazitaxel, Nails Important contra-indications noted in the
cabozantinib, calcifediol, calcium channel Onychocryptosis [2] prescribing guidelines for: nursing mothers;
blockers, carbamazepine, chlordiazepoxide, Paronychia [5] pediatric patients
ciclesonide, cisapride, clarithromycin, Pyogenic granuloma [3] Note: NSAIDs may cause an increased risk of
clonazepam, clorazepate, colchicine, conivaptan, serious cardiovascular and gastrointestinal
copanlisib, corticosteroids, crizotinib, Mucosal adverse events, which can be fatal. This risk may
cyclosporine, CYP3A4 inducers and substrates, Aphthous stomatitis (<2%)
increase with duration of use.
darifenacin, darunavir, dasatinib, deferasirox, Cheilitis [4]
Litt’s Drug Eruption & Reaction Manual INFLIXIMAB
Warning: RISK OF SERIOUS severe heart failure (New York Heart Association Paresthesias (<4%) [2]
CARDIOVASCULAR AND Functional Class III/IV). Peripheral neuropathy [7]
GASTROINTESTINAL EVENTS Warning: SERIOUS INFECTIONS and Seizures [2]
MALIGNANCY Vertigo (dizziness) [3]
Skin Neuromuscular/Skeletal
Angioedema [2] Skin Arthralgia (<8%) [15]
Bullous dermatitis [2] Abscess [4] Asthenia (fatigue) (9%) [4]
Dermatitis [5] Acneform eruption [6] Back pain (8%)
Dermatitis herpetiformis (exacerbation) [2] AGEP [2] Myalgia/Myopathy (5%) [7]
Edema (39%) Anaphylactoid reactions/Anaphylaxis [10] Polymyositis [2]
Exanthems (<5%) [7] Angioedema [2] Gastrointestinal/Hepatic
Fixed eruption [2] Candidiasis (5%) [4] Abdominal pain (12%) [3]
Pruritus (<10%) [3] Cellulitis [5] Crohn’s disease (26%)
Psoriasis [7] Dermatitis [4] Diarrhea (12%)
Purpura [5] Eczema [5] Dyspepsia (10%)
Rash (>10%) Edema [3] Hepatitis [11]
Toxic epidermal necrolysis [6] Erythema multiforme [2] Hepatotoxicity [16]
Urticaria [7] Exanthems [4] Nausea (21%) [3]
Vasculitis [5] Folliculitis [2] Pancreatitis [2]
Mucosal Hand–foot syndrome [2]
Herpes [2] Respiratory
Oral lesions (<7%) [2] Bronchitis (10%)
Oral ulceration [4] Herpes simplex [4]
Herpes zoster [11] Cough (12%) [3]
Central Nervous System Hypersensitivity [11] Dyspnea (6%) [3]
Psychosis [3] Leukocytoclastic vasculitis [2] Pharyngitis (12%)
Gastrointestinal/Hepatic Lichen planus [2] Pneumonia [12]
Gastrointestinal bleeding [2] Lichenoid eruption [3] Pulmonary toxicity [6]
Gastrointestinal perforation [3] Lupus erythematosus [35] Rhinitis (8%)
Gastrointestinal ulceration [3] Lupus syndrome [11] Sinusitis (14%) [4]
Pancreatitis [2] Lymphoma [9] Tuberculosis [13]
Malignancies [2] Upper respiratory tract infection (32%) [6]
Otic
Tinnitus [2] Molluscum contagiosum [2] Endocrine/Metabolic
Neoplasms [2] ALT increased [2]
Ocular Nevi [2]
Periorbital edema [2] Genitourinary
Palmar–plantar pustulosis [3] Cystitis [2]
Other Pityriasis lichenoides chronica [2] Urinary tract infection (8%) [2]
Adverse effects [8] Pruritus (7%) [8]
Pseudolymphoma [2] Renal
Psoriasis [56] Nephrotoxicity [2]
Pustules [5] Hematologic
INDORAMIN Rash (10%) [13] Neutropenia [5]
Sarcoidosis [5] Sepsis [2]
Serum sickness [2] Thrombocytopenia [5]
Serum sickness-like reaction (<3%) [5]
Ocular
INFLIXIMAB Toxicity [2]
Optic neuritis [3]
Uveitis [2]
Urticaria [6]
Trade names: Inflectra (Celltrion) ((Remsima)), Vasculitis [18] Local
Remicade (Centocor), Renflexis (Samsung Vitiligo [4] Application-site reactions (mild) (<4%) [6]
Bioepsis) Infusion-related reactions [20]
Indications: Crohn’s disease, ulcerative colitis,
Hair Infusion-site reactions (20%) [12]
Alopecia [6]
rheumatoid arthritis, ankylosing spondylitis, Injection-site reactions (6%) [9]
psoriatic arthritis, plaque psoriasis
Alopecia areata [3]
Other
Class: Cytokine inhibitor, Disease-modifying Cardiovascular
antirheumatic drug (DMARD), Monoclonal Cardiotoxicity [2]
antibody, TNF inhibitor Chest pain [4]
Death [13]
Half-life: 8–10 days Flushing [2]
Infection (36%) [58]
Clinically important, potentially hazardous Hypertension (7%) [3]
Nocardiosis [3]
interactions with: abatacept, anakinra, live Palpitation [2]
Side effects [2]
vaccines, methotrexate, tocilizumab Pericarditis [2]
Systemic reactions [2]
Pregnancy category: B Tachycardia [2]
Important contra-indications noted in the Central Nervous System
prescribing guidelines for: the elderly; nursing Aseptic meningitis [2]
mothers Chills (59%) [2]
Note: TNF inhibitors should be used in patients Demyelination [3]
with heart failure only after consideration of other Fever (7%) [10]
treatment options. Headache (18%) [11]
Contra-indicated in patients with a personal or Leukoencephalopathy [2]
family history of multiple sclerosis or Neurotoxicity [8]
demyelinating disease. TNF inhibitors should not Pain (8%) [3]
be administered to patients with moderate to
INFLUENZA VACCINE Over 100 updates per week on www.drugeruptiondata.com
Cardiovascular
INFLUENZA VACCINE INGENOL MEBUTATE Hypotension [2]
Veno-occlusive disease (23%) [4]
Trade names: Afluria (Seqirus), Agrippal Trade name: Picato (Leo Pharma)
(Chiron), Comvax (Merck), Fluad (Novartis), Indications: Actinic keratosis Central Nervous System
Fluarix (GSK), FluMist (Medimmune) (Wyeth), Class: Cell death inducer Chills (11%)
Flurix (GSK), Fluviral (Shire), Inflexal V (Berna Half-life: N/A Fever (32%) [4]
Biotech), Invivac (Solvay), Vaxigrip (Sanofi- Clinically important, potentially hazardous Headache (28%) [2]
Aventis) interactions with: none known Neuromuscular/Skeletal
Indications: Influenza prevention Pregnancy category: C Asthenia (fatigue) (35%) [2]
Class: Vaccine Important contra-indications noted in the Gastrointestinal/Hepatic
Half-life: N/A prescribing guidelines for: pediatric patients Abdominal distension (6%)
Clinically important, potentially hazardous Abdominal pain (23%)
interactions with: aminophylline, Skin Ascites (4%)
carbamazepine, cyclosporine, mercaptopurine, Crusting [4] Constipation (16%)
phenobarbital, phenytoin, prednisone, vincristine, Erythema [4] Diarrhea (17%)
warfarin Flaking [4] Hepatotoxicity (14%) [3]
Pregnancy category: C Scaling [3] Nausea (31%) [4]
Important contra-indications noted in the Vomiting (15%)
prescribing guidelines for: pediatric patients Central Nervous System
Note: Inactivated influenza vaccine should not be Headache (2%) [4] Respiratory
given to persons with anaphylactic Respiratory Pneumonia [2]
hypersensitivity to eggs or other components of Nasopharyngitis (2%) [2] Endocrine/Metabolic
the vaccine. For current data on influenza in the Ocular ALP increased (13%)
USA consult the Centers for Disease Control and Eyelid edema [2] ALT increased (>10%) [2]
Protection website (www.cdc.gov/flu). Periorbital edema (3%) [2] Appetite decreased (12%)
AST increased (>10%) [3]
Local GGT increased (21%)
Skin Application-site erythema [2]
Anaphylactoid reactions/Anaphylaxis (rare) Hyperbilirubinemia (21%) [5]
Application-site infection (3%) [2] Hyperuricemia (4%)
[3] Application-site pain (2–15%) [6]
Henoch–Schönlein purpura [2] Application-site pruritus (8%) [4] Hematologic
Hypersensitivity [2] Application-site reactions [3] Anemia (36%)
Linear IgA bullous dermatosis [2] Febrile neutropenia (26%) [2]
Purpura [2] Hemorrhage (33%)
Rash [3] Hyperlipasemia (9%)
Serum sickness-like reaction [2] INOSITOL Leukopenia (35%) [3]
Vasculitis [10] Lymphopenia (18%) [4]
See: www.drugeruptiondata.com/drug/id/1376 Myelosuppression (>10%)
Fever [13] Neutropenia (49%) [9]
Guillain–Barré syndrome [11] Pancytopenia (2%)
Headache [9] INOTUZUMAB Thrombocytopenia (51%) [9]
Seizures [3] Local
OZOGAMICIN * Infusion-related reactions (2%)
Arthralgia [2] Trade name: Besponsa (Wyeth) Other
Asthenia (fatigue) [7] Indications: Relapsed or refractory B-cell Infection (48%) [2]
Myalgia/Myopathy [11] precursor acute lymphoblastic leukemia
Polymyositis [4] Class: Antibody drug conjugate (ADC), CD22-
Gastrointestinal/Hepatic directed antibody-drug conjugate
Half-life: 12 days
INSULIN
Abdominal pain [2]
Respiratory interactions with: none known
Asthma [2]
Cough [2]
harm)
Hematologic Important contra-indications noted in the INSULIN ASPART
Thrombocytopenia [2] prescribing guidelines for: nursing mothers;
pediatric patients Trade names: NovoLog (Novo Nordisk),
Ocular NovoRapid (Novo Nordisk), Ryzodeg (Novo
Oculorespiratory syndrome [15] Warning: HEPATOTOXICITY, INCLUDING
HEPATIC VENOOCCLUSIVE DISEASE (ALSO Nordisk)
Optic neuritis [2] Indications: Diabetes mellitus
KNOWN AS SINUSOIDAL OBSTRUCTION
Local SYNDROME) and INCREASED RISK OF Class: Hormone, polypeptide
Injection-site edema [4] POSTHEMATOPOIETIC STEM CELL Half-life: 81 minutes
Injection-site erythema [7] TRANSPLANT NONRELAPSE MORTALITY Clinically important, potentially hazardous
Injection-site induration [5] interactions with: ACE inhibitors, alcohol,
Injection-site inflammation [3] atypical antipsychotics, beta blockers, clonidine,
Injection-site pain (2028%) [15] Skin corticosteroids, danazol, disopyramide, diuretics,
Injection-site reactions [3] Hypersensitivity (2%) epinephrine, estrogens, fibrates, fluoxetine,
Tumor lysis syndrome (2%) isoniazid, isoniazid, lithium salts, MAO inhibitors,
Other
Adverse effects [7] Mucosal niacin, octreotide, oral contraceptives,
Side effects [4] Stomatitis (13%) pentamidine, phenothiazine derivatives,
Systemic reactions (injection site) [5] pramlintide, propoxyphene, salbutamol,
Litt’s Drug Eruption & Reaction Manual INSULIN GLARGINE
salicylates, somatropin, sulfonamide antibiotics, Skin Endocrine/Metabolic

terbutaline, thyroid hormones Hypersensitivity [2] Hyperglycemia [2]
Pregnancy category: B Peripheral edema (<3%) Hypoglycemia [4]
Important contra-indications noted in the Central Nervous System Local
prescribing guidelines for: the elderly; pediatric Headache (9–12%) [10] Injection-site reactions (34%) [4]
patients
Note: Ryzodeg is insulin aspart and insulin Gastrointestinal/Hepatic Other
degludec; various forms of insulin are available - Diarrhea (6%) [6] Allergic reactions [3]
see other insulin profiles for reaction details. Gastroenteritis (5%) Infection (viral) (7%)
Nausea [7]
Vomiting [2]
Skin
Lipodystrophy (>5%) Respiratory INSULIN GLARGINE
Peripheral edema (>5%) Nasopharyngitis (13–24%) [11]
Sinusitis (5%) Trade names: Basaglar (Lilly), Lantus (Sanofi-
Nails Upper respiratory tract infection (8–12%) Aventis), Soliqua (Sanofi-Aventis)
Onychomycosis (10%) [3] Indications: Diabetes (Type I or II)
Cardiovascular Endocrine/Metabolic Class: Hormone analog, polypeptide
Chest pain (5%) Diabetic ketoacidosis [2] Half-life: N/A
Central Nervous System Hypoglycemia [9] Clinically important, potentially hazardous
Headache (12%) [2] interactions with: ACE inhibitors, albuterol,
Ocular alcohol, beta blockers, clonidine, clozapine,
Hyporeflexia (11%) Retinopathy [2] corticosteroids, danazol, disopyramide, diuretics,
Gastrointestinal/Hepatic Local epinephrine, estrogens, fibrates, fluoxetine,
Abdominal pain (5%) Injection-site reactions (4%) [6] glucagon, guanethidine, isoniazid, lithium, MAO
Diarrhea (5%) inhibitors, niacin, olanzapine, oral antidiabetic
Nausea (7%) Other
products, oral contraceptives, pentamidine,
Adverse effects [4]
Respiratory pentoxifylline, phenothiazine derivatives,
Nasopharyngitis [2] pramlintide, propoxyphene, propranolol,
Sinusitis (5%) protease inhibitors, reserpine, salicylates,
Endocrine/Metabolic
INSULIN DETEMIR somatostain analogs, somatropin, sulfonamide
Diabetic ketoacidosis [2] antibiotics, terbutaline, thyroid hormones
Trade name: Levemir (Novo Nordisk) Pregnancy category: C
Hypoglycemia (75%) [5] Indications: Diabetes (Type I or II)
Weight gain (>5%) Important contra-indications noted in the
Class: Human insulin analog, long-acting prescribing guidelines for: nursing mothers;
Genitourinary Half-life: 57 hours pediatric patients
Urinary tract infection (8%) Clinically important, potentially hazardous Note: Soliqua is insulin glargine and lixisenatide;
interactions with: albuterol, alcohol, various forms of insulin are available - see other
antipsychotics, beta blockers, clonidine, insulin profiles for reaction details.
INSULIN DEGLUDEC clozapine, corticosteroids, danazol, diuretics,
epinephrine, estrogens, guanethidine, isoniazid,
lithium, niacin, olanzapine, oral antidiabetics, oral Skin
Trade names: Ryzodeg (Novo Nordisk), Tresiba Lipoatrophy [2]
(Novo Nordisk), Xultophy (Novo Nordisk) contraceptives, pentamidine, phenothiazines,
propranolol, protease inhibitors, reserpine, Peripheral edema (20%)
Indications: Diabetes mellitus
Class: Human insulin analog, long-acting somatropin, terbutaline, thiazolidinediones, Central Nervous System
Half-life: 25 hours thyroid hormones Depression (11%)
Clinically important, potentially hazardous Pregnancy category: B Headache (6–10%) [4]
interactions with: ACE inhibitors, albuterol, Important contra-indications noted in the Neuromuscular/Skeletal
alcohol, angiotensin II receptor blocking agents, prescribing guidelines for: the elderly; nursing Arthralgia (14%)
beta blockers, clonidine, clozapine, mothers; pediatric patients Back pain (13%)
corticosteroids, danazol, DDP-4-inhibitors, Note: Various forms of insulin are available - see Pain in extremities (13%)
disopyramide, diuretics, epinephrine, estrogens, other insulin profiles for reaction details.
fibrates, fluoxetine, GLP-1 receptor agonists, Diarrhea (11%) [6]
glucagon, guanethidine, isoniazid, lithium, MAO Central Nervous System Nausea [5]
inhibitors, niacin, octreotide, olanzapine, oral Fever (10%) Vomiting [4]
contraceptives, pentamidine, pentoxifylline, Headache (7–31%) [3]
phenothiazines, pramlintide, propoxyphene, Respiratory
Neuromuscular/Skeletal Bronchitis (15%)
protease inhibitors, reserpine, salicylates, SGLT-2 Back pain (8%)
inhibitors, somatropin, sulfonamide antibiotics, Cough (12%)
terbutaline, thyroid hormones Gastrointestinal/Hepatic Influenza (19%)
Pregnancy category: C Abdominal pain (6–13%) Nasopharyngitis [6]
Important contra-indications noted in the Gastroenteritis (6–17%) Pharyngitis (8%)
prescribing guidelines for: the elderly; nursing Nausea (7%) Rhinitis (5%)
mothers; pediatric patients Vomiting (7%) Sinusitis (19%)
Note: Contra-indicated during episodes of Respiratory Upper respiratory tract infection (11–29%)
hypoglycemia. Ryzodeg is insulin degludec and Bronchitis (5%) [3]
insulin aspart; Xultophy is insulin degludec and Cough (8%) Endocrine/Metabolic
liraglutide; various forms of insulin are available - Flu-like syndrome (6–14%) Hypoglycemia [4]
see other insulin profiles for reaction details. Pharyngitis (10–17%) Genitourinary
Rhinitis (7%) Urinary tract infection (11%)
Upper respiratory tract infection (13–36%)
INSULIN GLARGINE See all our books at www.crcpress.com
Ocular Cardiovascular
Cataract (18%) INTERFERON ALFA Cardiotoxicity [2]
Retinopathy [2] Hypertension [3]
Synonyms: IFN; INF Hypotension [2]
Local Trade names: Infergen (Intermune), Intron A
Injection-site pain (3%) (Schering), Rebetron (Schering), Roferon-A Central Nervous System
Injection-site reactions [4] (Roche) Ageusia (taste loss) [2]
Other Indications: Chronic hepatitis C virus infection, Anorexia [4]
Adverse effects [5] hairy cell leukemia Anosmia [4]
Infection (9–14%) Class: Biologic, Immunomodulator, Interferon Anxiety [2]
Half-life: 2 hours Chills [4]
Clinically important, potentially hazardous Depression (515%) [24]
Dysgeusia (taste perversion) [K] (25%) [2]
INSULIN GLULISINE interactions with: aldesleukin, amitriptyline,
captopril, gemfibrozil, metaxalone, methadone, Fever (37%) [6]
ribavirin, telbivudine, theophylline, theophylline Headache (54%) [5]
Trade name: Apidra (Sanofi-Aventis) Insomnia (19%)
Indications: Diabetes derivatives, zafirlukast, zidovudine
Pregnancy category: C (pregnancy category Irritability [2]
Class: Insulin analog Neurotoxicity [4]
Half-life: 13–42 minutes will be X when used in combination with
ribavirin) Paresthesias 8% [L] (12%)
Clinically important, potentially hazardous Parkinsonism [3]
interactions with: ACE inhibitors, albuterol, Important contra-indications noted in the
prescribing guidelines for: nursing mothers; Restless legs syndrome [2]
alcohol, anitpsychotics, beta blockers, clonidine, Rigors (35%)
clozapine, corticosteroids, danazol, disopyramide, pediatric patients
Note: Many of the adverse reactions depend on Seizures [2]
diuretics, epinephrine, fibrates, fluoxetine, Suicidal ideation [6]
glucagon, guanethidine, isoniazid, lithium, MAO the nature of the disease being treated. Either
hairy cell leukemia [L] or AIDS-related Kaposi’s Tremor [2]
inhibitors, niacin, oral antidiabetic agents, oral Vertigo (dizziness) (16%) [2]
contraceptives, pentamidine, pentoxifylline, sarcoma [K].
phenothiazine derivatives, pramlintide, Neuromuscular/Skeletal
propoxyphene, propranolol, protease inhibitors, Skin Arthralgia (28%) [4]
reserpine, salicylates, somatostatin analogs, Angioedema [3] Asthenia (fatigue) (56%) [11]
somatropin, sulfonamide antibiotics, terbutaline, Bullous dermatitis [4] Back pain (9%)
thyroid hormones Dermatitis (6%) Myalgia/Myopathy 69% [L] 71% [K] [10]
Pregnancy category: C Eczema [6] Myasthenia gravis [11]
Important contra-indications noted in the Edema [L] (11%) [2] Rhabdomyolysis [3]
prescribing guidelines for: nursing mothers; Erythema [2] Gastrointestinal/Hepatic
pediatric patients Exanthems [3] Abdominal pain (15%)
Note: Various forms of insulin are available - see Herpes simplex [2] Constipation [2]
other insulin profiles for reaction details. Kaposi’s sarcoma [2] Diarrhea (24%) [5]
Lichen planus [8] Nausea (24%) [7]
Skin Linear IgA bullous dermatosis [3] Pancreatitis [7]
Peripheral edema (8%) Livedo reticularis [2] Vomiting [5]
Lupus erythematosus [17] Respiratory
Cardiovascular Lupus syndrome [2]
Hypertension (4%) Cough [2]
Necrosis [6] Dyspnea (13%) [2]
Central Nervous System Pemphigus [2] Flu-like syndrome (>10%) [10]
Headache (7%) Photosensitivity [2] Pulmonary hypertension [2]
Neuromuscular/Skeletal Pigmentation [3]
Pruritus 13% [L] 5–7% [K] (13%) [4] Endocrine/Metabolic
Arthralgia (6%) ALT increased [2]
Psoriasis [22]
Respiratory Purpura [2] AST increased [2]
Influenza (4–6%) Rash 44% [L] 11% [K] [5] Hyperglycemia [2]
Nasopharyngitis (8–11%) Raynaud’s phenomenon [11] Hyperthyroidism [3]
Upper respiratory tract infection (7–11%) Sarcoidosis [47] Thyroid dysfunction [3]
Endocrine/Metabolic Seborrheic dermatitis [2] Thyroiditis [2]
Hypoglycemia (6–7%) [3] Sjögren’s syndrome [4] Weight loss (16%) [5]
Thrombocytopenic purpura [2] Genitourinary
Local
Toxicity [4] Impotence [2]
Urticaria [K] (<3%) [3] Renal
Vasculitis [7] Nephrotoxicity [3]
Vitiligo [9] Proteinuria [2]
Hair Hematologic
Alopecia (23%) [16] Anemia (11%) [7]
Hair pigmentation [3] Febrile neutropenia [2]
Hypertrichosis [3] Hemolytic uremic syndrome [6]
Straight hair [2] Leukopenia [5]
Mucosal Lymphopenia (14%)
Aphthous stomatitis [2] Neutropenia (21%) [5]
Oral lichen planus [7] Thrombocytopenia [7]
Stomatitis (<10%) Otic
Xerostomia (>10%) [4] Tinnitus [4]
Litt’s Drug Eruption & Reaction Manual IPILIMUMAB
Ocular Asthenia (fatigue) [2]

Eyelashes – hypertrichosis [3] Myalgia/Myopathy (44%) IOBENGUANE
Optic neuropathy [4] Rhabdomyolysis [2]
Retinopathy [6] See: www.drugeruptiondata.com/drug/id/1324
Vision blurred (4%) Hepatotoxicity [5]
Local Respiratory
Injection-site alopecia [2] Flu-like syndrome (61%) [14]
IODIXANOL
Injection-site erythema [2] Upper respiratory tract infection (31%)
Injection-site induration [3] See: www.drugeruptiondata.com/drug/id/1116
Injection-site necrosis [16] Endocrine/Metabolic
Mastodynia (7%)
Other Thyroid dysfunction [4]
Adverse effects [6] IODOQUINOL
Infection [4] Genitourinary
Vogt-Koyanagi-Harada syndrome [6] Vaginitis (4%) See: www.drugeruptiondata.com/drug/id/1345
Renal
Nephrotoxicity [2]
INTERFERON BETA Hematologic IOHEXOL
Hemolytic uremic syndrome [3]
Trade names: Avonex (Biogen), Betaferon Thrombotic microangiopathy [4] See: www.drugeruptiondata.com/drug/id/1267
(Bayer), Betaseron (Bayer), Plegridy (Biogen), Ocular
Rebif (Merck) Retinopathy [3]
Indications: Relapsing multiple sclerosis, cancers
Local
IOMEPROL
Class: Immunomodulator, Interferon
Half-life: 10 hours Injection-site ecchymoses (2%) See: www.drugeruptiondata.com/drug/id/1396
Clinically important, potentially hazardous Injection-site inflammation (3%)
interactions with: theophylline, theophylline Injection-site necrosis [3]
Injection-site purpura (2%)
derivatives, zidovudine
Pregnancy category: C Injection-site reactions (4%) [9] IOPROMIDE
Important contra-indications noted in the Other See: www.drugeruptiondata.com/drug/id/1220
prescribing guidelines for: nursing mothers; Adverse effects [4]
pediatric patients Death [4]
Infection (11%) [3]
Skin
IOTHALAMATE
Cyst (4%) See: www.drugeruptiondata.com/drug/id/1416
Diaphoresis (23%) INTERFERON GAMMA *
Edema (generalized) (8%)
Herpes simplex (23%) Trade name: Actimmune (Horizon)
Herpes zoster (3) Indications: Chronic granulomatous disease, IOVERSOL
Hypersensitivity (3%) severe malignant osteopetrosis
Lipoatrophy [2] See: www.drugeruptiondata.com/drug/id/1417
Class: Immunomodulator, Interferon
Lupus erythematosus [8] Half-life: 6 hours
Nevi (3%) Clinically important, potentially hazardous
Nicolau syndrome [2] interactions with: tasonermin, typhoid vaccine IPILIMUMAB
Rash [2] Pregnancy category: N/A (May cause fetal
Raynaud’s phenomenon [2] toxicity based on findings in animal studies) Trade name: Yervoy (Bristol-Myers Squibb)
Sarcoidosis [2] Important contra-indications noted in the Indications: Melanoma
Thrombocytopenic purpura [4] prescribing guidelines for: nursing mothers; Class: Biologic, CTLA-4-blocking monoclonal
Urticaria (5%) pediatric patients antibody, Monoclonal antibody
Vasculitis [4] Half-life: 15 days
Hair Clinically important, potentially hazardous
Skin
Alopecia (4%) interactions with: none known
Rash (17%)
Mucosal Central Nervous System Important contra-indications noted in the
Mucosal bleeding (1238%) Chills (14%) [3] prescribing guidelines for: nursing mothers;
Cardiovascular Fever (52%) [8] pediatric patients
Capillary leak syndrome [3] Headache (33%) [3] Warning: IMMUNE-MEDIATED ADVERSE
Neuromuscular/Skeletal REACTIONS
Chills (21%) Arthralgia (2%)
Depression [8] Asthenia (fatigue) (14%) [3] Skin
Fever [4] Myalgia/Myopathy (6%) Dermatitis (12%) [12]
Headache [4] Gastrointestinal/Hepatic Dermatomyositis [2]
Multiple sclerosis [2] Diarrhea (14%) Erythema [3]
Pain (52%) Nausea (10%) Exanthems [5]
Paresthesias [2] Vomiting (13%) Granulomas [3]
Psychosis [2] Lymphadenopathy [2]
Respiratory
Seizures (2%) [2] Pruritus (21–31%) [22]
Vertigo (dizziness) (35%) Rash (19–29%) [28]
Local Sarcoidosis [4]
Neuromuscular/Skeletal Injection-site erythema (14%) [2]
Arthralgia [2] Stevens-Johnson syndrome [3]
IPILIMUMAB Over 100 updates per week on www.drugeruptiondata.com
Toxic epidermal necrolysis [3] Local prostacyclin analogues, rifamycin derivatives,

Toxicity [3] Infusion-related reactions [4] rituximab, tacrolimus, tizanidine, tolvaptan,
Urticaria (2%) [2] Injection-site reactions [2] trimethoprim
Vitiligo [3] Other Pregnancy category: D (category C in first
Hair Adverse effects [28] trimester; category D in second and third
Alopecia [3] Death [12] trimesters)
Cardiovascular prescribing guidelines for: nursing mothers;
Atrial fibrillation [2] pediatric patients
Myocarditis [3] IPODATE Note: Avalide is irbesartan and
Pericarditis [2] hydrochlorothiazide. Hydrochlorothiazide is a
Central Nervous System See: www.drugeruptiondata.com/drug/id/364 sulfonamide which can be absorbed systemically.
Anorexia [3] Sulfonamides can produce severe, possibly fatal,
Chills [2] reactions such as toxic epidermal necrolysis and
Encephalitis [2] IPRATROPIUM Stevens-Johnson syndrome.
Encephalopathy [4] Warning: FETAL TOXICITY
Fever [4] Trade names: Atrovent (Boehringer Ingelheim),
Guillain–Barré syndrome [5] Combivent (Boehringer Ingelheim), Duoneb Skin
Headache (14%) [3] (Mylan Specialty), Ipratropium Steri-Neb (Ivax), Angioedema [3]
Neurotoxicity [5] Rinatec (Boehringer Ingelheim) Edema (<10%)
Neuromuscular/Skeletal Indications: Bronchospasm Peripheral edema [2]
Arthralgia [4] Class: Anticholinergic, Muscarinic antagonist Rash (<10%)
Asthenia (fatigue) (34–41%) [11] Half-life: 2 hours
Clinically important, potentially hazardous Gastrointestinal/Hepatic
Myalgia/Myopathy [3] Pancreatitis [2]
Myasthenia gravis [5] interactions with: anticholinergics
Rhabdomyolysis [2] Pregnancy category: B Respiratory
Important contra-indications noted in the Cough [2]
Gastrointestinal/Hepatic prescribing guidelines for: nursing mothers
Abdominal pain [3] Note: Combivent is ipratropium and albuterol.
Colitis (5–8%) [48]
Constipation [2] IRINOTECAN
Diarrhea (32–37%) [44] Mucosal
Enterocolitis (7%) [6] Oral lesions (<5%) Trade names: Camptosar (Pfizer), Onivyde
Gastrointestinal perforation [5] Oral ulceration [2] (Merrimack)
Hepatitis [15] Xerostomia (3%) [3] Indications: Metastatic colorectal carcinoma
Hepatotoxicity (<2%) [19] Central Nervous System (Camptosar), metastatic adenocarcinoma of the
Nausea [4] Dysgeusia (taste perversion) [2] pancreas (Onivyde - in combination with
Pancreatitis [4] Trembling (<10%) fluorouracil and leucovorin)
Vomiting [2] Class: Antineoplastic, Topoisomerase 1 inhibitor
Ocular Half-life: 610 hours
Respiratory Mydriasis [2] Clinically important, potentially hazardous
Dyspnea [2] Other interactions with: aprepitant, atazanavir,
Pneumonia [5] Adverse effects [2] bevacizumab, ketoconazole, lapatinib, safinamide,
Pneumonitis [9] sorafenib, St John’s wort, strong CYP3A4
Endocrine/Metabolic inhibitors, voriconazole
Adrenal insufficiency [3] Pregnancy category: D
ALT increased [11]
IRBESARTAN Important contra-indications noted in the
AST increased [9] prescribing guidelines for: the elderly; nursing
Trade names: Aprovel (Bristol-Myers Squibb),
Hyperthyroidism [3] mothers; pediatric patients
Avalide (Bristol-Myers Squibb), Avapro (Sanofi-
Hyponatremia [3] Warning: DIARRHEA and
Aventis)
Hypophysitis [34] MYELOSUPPRESSION (Camptosar)
Indications: Hypertension, diabetic nephropathy
Hypopituitarism (<4%) Class: Angiotensin II receptor antagonist SEVERE NEUTROPENIA and SEVERE DIAR-
Hypothyroidism [10] (blocker), Antihypertensive RHEA (Onivyde)
Thyroid dysfunction [4] Half-life: 1115 hours
Thyroiditis [12] Clinically important, potentially hazardous
Weight loss [2] Skin
interactions with: ACE inhibitors, adrenergic Acneform eruption [4]
Renal neurone blockers, alcohol, aldesleukin, Exfoliative dermatitis (14%)
Nephrotoxicity [7] aldosterone antagonists, aliskiren, alpha blockers, Hand–foot syndrome [6]
Renal failure [4] alprostadil, amifostine, antihypertensives, Pruritus [4]
Hematologic antipsychotics, anxiolytics and hypnotics, Rash (46%) [7]
Anemia [3] baclofen, beta blockers, calcium channel blockers, Toxicity [3]
Hyperlipasemia [2] carvedilol, clonidine, corticosteroids,
cyclosporine, CYP2C8 and CYP2C9 substrates,
Hair
Neutropenia [6] Alopecia (1361%) [24]
Thrombocytopenia [6] diazoxide, diuretics, eplerenone, fluconazole,
general anesthetics, heparins, hypotensives, Mucosal
Ocular levodopa, lithium, MAO inhibitors, methyldopa, Mucositis (30%) [2]
Iridocyclitis [3] methylphenidate, moxisylyte, moxonidine, Stomatitis (<14%) [5]
Orbital inflammation [3] nitrates, NSAIDs, pentoxifylline,
Retinitis [2] Cardiovascular
phosphodiesterase 5 inhibitors, potassium salts, Bradycardia [2]
Uveitis [8]
Xerophthalmia [2] Flushing (11%)
Hypertension [8]
Litt’s Drug Eruption & Reaction Manual ISONIAZID
Hypotension (5%) Exfoliative dermatitis (<5%) Respiratory failure (7%)

Thrombophlebitis (<10%) Hypersensitivity (<5%) Tachypnea (<5%)
Vasodilation (6%) Peripheral edema (15%) Endocrine/Metabolic
Central Nervous System Petechiae (<5%) Appetite decreased (9%)
Anorexia (44%) [18] Pruritus (8%) Hypoalbuminemia (<5%)
Chills (14%) Rash (9%) Hypoglycemia (<5%)
Confusion (3%) Urticaria (<5%) Hypokalemia (19%)
Dysarthria [2] Hair Hypomagnesemia (5%)
Fever (44%) [3] Alopecia (<5%) Hyponatremia (<5%)
Insomnia [2] Mucosal Genitourinary
Neurotoxicity [5] Gingivitis (<5%) Hematuria (<5%)
Pain (23%) Stomatitis (<5%)
Somnolence (drowsiness) (9%) Renal
Vertigo (dizziness) (21%) Cardiovascular Proteinuria (<5%)
Atrial fibrillation (<5%) Renal failure (10%)
Neuromuscular/Skeletal Atrial flutter (<5%)
Asthenia (fatigue) (69%) [19] Hematologic
Bradycardia (<5%) Agranulocytosis (<5%)
Gastrointestinal/Hepatic Cardiac arrest (<5%) Leukopenia (<5%)
Abdominal pain (68%) [3] Chest pain (9%) Pancytopenia (<5%)
Constipation (32%) [2] Extrasystoles (<5%)
Diarrhea (83%) [41] Hypotension (8%) Otic
Hepatotoxicity [3] Palpitation (<5%) Tinnitus (<5%)
Nausea (82%) [20] QT interval shortening (<5%) Ocular
Vomiting (63%) [17] Thrombophlebitis (<5%) Optic neuropathy (<5%)
Respiratory Central Nervous System Local
Cough (20%) Anxiety (8%) Injection-site reactions (6%)
Dyspnea (22%) Chills (<5%) Other
Pneumonia (4%) [4] Confusion (<5%) Adverse effects [3]
Endocrine/Metabolic Delirium (9%)
Dehydration [4] Depression (<5%)
Renal Encephalopathy (<5%) ISOCARBOXAZID
Proteinuria [4] Gait instability (<5%)
Hematologic Hallucinations (<5%) See: www.drugeruptiondata.com/drug/id/368
Anemia (97%) [15] Headache (17%)
Febrile neutropenia [10] Hypoesthesia (<5%)
Leukopenia (96%) [12] Insomnia (11%) ISOETHARINE
Lymphopenia [2] Migraine (<5%)
Neutropenia (96%) [40] Paresthesias (<5%) See: www.drugeruptiondata.com/drug/id/369
Thrombocytopenia (96%) [8] Peripheral neuropathy (<5%)
Other Seizures (<5%)
Somnolence (drowsiness) (<5%)
Adverse effects [3]
Stupor (<5%)
ISOFLURANE
Allergic reactions (9%)
Death [5] Syncope (<5%) See: www.drugeruptiondata.com/drug/id/950
Infection (14%) [2] Tremor (<5%)
Neuromuscular/Skeletal ISONIAZID
ISAVUCONAZONIUM Back pain (10%) Synonym: INH
SULFATE Bone or joint pain (<5%) Trade names: Rifamate (Sanofi-Aventis), Rifater
Myalgia/Myopathy (<5%) (Sanofi-Aventis)
Trade name: Cresemba (Astellas) Neck pain (<5%) Indications: Tuberculosis
Indications: Invasive aspergillosis, mucormycosis Gastrointestinal/Hepatic Class: Antibiotic, Antimycobacterial
Class: Antifungal, azole Abdominal distension (<5%) Half-life: <4 hours
Half-life: 130 hours Abdominal pain (17%) Clinically important, potentially hazardous
Clinically important, potentially hazardous Cholecystitis (<5%) interactions with: acetaminophen,
interactions with: carbamazepine, Cholelithiasis (gallstones) (<5%) betamethasone, ethosuximide, insulin aspart,
ketoconazole, rifampin, ritonavir, St John’s wort, Constipation (14%) insulin degludec, insulin detemir, insulin glargine,
strong CYP3A4 inducers or inhibitors Diarrhea (24%) [3] insulin glulisine, itraconazole, levodopa,
Pregnancy category: C Dyspepsia (6%) metformin, phenytoin, prednisolone, propranolol,
Important contra-indications noted in the Gastritis (<5%) rifampin, rifapentine, safinamide, triamcinolone
prescribing guidelines for: nursing mothers; Hepatic failure (<5%) Pregnancy category: C
pediatric patients Hepatomegaly (<5%)
Note: Contra-indicated in patients with familial Hepatotoxicity (17%)
short QT syndrome.
Skin
Nausea (28%) [3] Acneform eruption [7]
Vomiting (25%) AGEP [2]
Skin Respiratory Angioedema [2]
Dermatitis (<5%) Bronchospasm (<5%) Bullous dermatitis [2]
Erythema (<5%) Dyspnea (17%) Dermatitis [3]
ISONIAZID See all our books at www.crcpress.com
DRESS syndrome [6] Pregnancy category: X

Erythema multiforme [2] ISOSORBIDE Important contra-indications noted in the
Exanthems [4] prescribing guidelines for: nursing mothers;
Exfoliative dermatitis [5] DINITRATE pediatric patients
Hypersensitivity [7] Note: Oral retinoids can cause birth defects, and
Trade names: Dilatrate-SR (Schwarz), Isordil
Lichenoid eruption [2] women should avoid isotretinoin when pregnant
(Wyeth), Sorbitrate (AstraZeneca)
Lupus erythematosus [58] or trying to conceive.
Indications: Angina pectoris
Class: Nitrate, Vasodilator
Photosensitivity [5] Skin
Half-life: 4 hours (oral)
Pruritus [3] Abscess [3]
Purpura [7] Acneform eruption [19]
interactions with: sildenafil
Pustules [3] Angioedema [3]
Stevens-Johnson syndrome [5] Desquamation (palms and soles) (5%)
Toxic epidermal necrolysis [9] Diaphoresis [2]
Toxicity [2] Edema (subcutaneous, recurrent) [2]
Urticaria (<5%) [4] Erythema nodosum [3]
Note: Various forms of isosorbide are available –
Vasculitis [2] Exfoliative dermatitis (<10%)
see other isosorbide profiles for reaction details.
Hair Facial edema (<10%)
Alopecia [3] Facial erythema [3]
Cardiovascular
Mucosal Fragility [3]
Flushing (>10%)
Oral lesions [2] Granulation tissue [4]
Central Nervous System Keloid [5]
Central Nervous System Headache [3] Pallor (<10%)
Fever [3] Photosensitivity (>10%) [7]
Hallucinations [3] Pigmentation [2]
Neurotoxicity [2]
Psychosis [2] ISOSORBIDE MONO- Pityriasis rosea [2]
Pruritus (<5%) [5]
Seizures [9] NITRATE Pyoderma gangrenosum [3]
Neuromuscular/Skeletal Rash [3]
Arthralgia [2] Trade names: Imdur (Schering), Monoket Sweet’s syndrome [2]
Rhabdomyolysis (3%) [3] (Schwarz) Urticaria [2]
Gastrointestinal/Hepatic Indications: Angina pectoris Vasculitis [4]
Hepatotoxicity [32] Class: Nitrate, Vasodilator Xanthomas [2]
Pancreatitis [4] Half-life: ~4 hours Xerosis (>10%) [12]
Clinically important, potentially hazardous Hair
Respiratory interactions with: sildenafil
Pleural effusion [2] Alopecia (16%) [3]
Pregnancy category: B Curly hair [3]
Endocrine/Metabolic Important contra-indications noted in the
Gynecomastia [4] prescribing guidelines for: the elderly; nursing Nails
mothers; pediatric patients Brittle nails [2]
Renal Elkonyxis [2]
Note: Various forms of isosorbide are available –
Nephrotoxicity [2] Median canaliform dystrophy [3]
Ocular Onycholysis [3]
Hallucinations, visual [2] Paronychia [4]
Cardiovascular Pyogenic granuloma [8]
Optic neuritis [2]
Flushing (>10%) [2]
Other Palpitation [2] Mucosal
Adverse effects [6] Cheilitis (>90%) [16]
Death [3]
Central Nervous System Epistaxis (nosebleed) [2]
Headache [7] Mucositis [2]
Side effects (2%) [2]
Vertigo (dizziness) [2] Xerostomia (>10%) [5]
Adverse effects [2]
ISOPROTERENOL Depression [7]
Headache [7]
See: www.drugeruptiondata.com/drug/id/371 Pseudotumor cerebri [4]
ISOTRETINOIN Neuromuscular/Skeletal
Arthralgia [4]
Synonym: 13-cis-retinoic acid
ISOSORBIDE Trade names: Accutane (Roche), Amnesteem
(Genpharm), Claravis (Barr), Roaccutane (Roche) Rhabdomyolysis [2]
Indications: Acute angle-closure glaucoma
Indications: Cystic acne Sacroiliitis [3]
Class: Diuretic
Class: Retinoid Stiff person syndrome [2]
Half-life: 21–24 hours
Clinically important, potentially hazardous Gastrointestinal/Hepatic
interactions with: sildenafil Abdominal pain [3]
interactions with: acitretin, alcohol (ethyl),
Pregnancy category: C Hepatotoxicity [3]
antacids, bexarotene, carbamazepine,
Note: Various forms of isosorbide are available – Pancreatitis [3]
cholestyramine, co-trimoxazole, corticosteroids,
dairy products, minocycline, oral contraceptives, Endocrine/Metabolic
phenytoin, retinoids, St John’s wort, tetracycline, Amenorrhea [2]
Central Nervous System tetracyclines, vitamin A Gynecomastia [2]
Headache [10] Hypercholesterolemia [2]
Litt’s Drug Eruption & Reaction Manual IVABRADINE
Hyperlipidemia [2] alafenamide, cobicistat/elvitegravir/emtricitabine/ Cardiovascular

Hypertriglyceridemia [5] tenofovir disoproxil, cobimetinib, colchicine, Cardiac arrest [2]
Hematologic conivaptan, copanlisib, corticosteroids, Cardiac failure [4]
Neutropenia [2] coumarins, crizotinib, cyclophosphamide, Congestive heart failure [4]
cyclosporine, cyproterone, dabigatran, Hypertension (3%) [3]
Ocular darifenacin, dasatinib, dexamethasone, diazepam, QT prolongation [5]
Ocular adverse effects [2] dicumarol, didanosine, digoxin, Torsades de pointes [2]
Photophobia [2] dihydroergotamine, dihydropyridines,
Xerophthalmia [2] Central Nervous System
disopyramide, docetaxel, dofetilide, dronedarone, Fever [2]
Other efavirenz, eletriptan, enzalutamide, eplerenone, Headache (4%) [3]
Adverse effects [8] ergotamine, erlotinib, erythromycin, estradiol, Neurotoxicity [5]
Side effects [2] ethotoin, everolimus, felodipine, fentanyl, Peripheral neuropathy [4]
Teratogenicity [8] fesoterodine, flibanserin, fluticasone propionate, Seizures [2]
fosamprenavir, fosphenytoin, gefitinib, grapefruit Tremor [2]
juice, halofantrine, haloperidol, histamine H2- Vertigo (dizziness) [2]
antagonists, HMG-CoA reductase inhibitors,
ISOXSUPRINE ibrutinib, iloperidone, imatinib, indinavir, Neuromuscular/Skeletal
irinotecan, isoniazid, ivabradine, ixabepilone, Asthenia (fatigue) [3]
See: www.drugeruptiondata.com/drug/id/376 Back pain [2]
lapatinib, lercanidipine, levomethadyl, lomitapide,
lopinavir, lovastatin, lurasidone, mephenytoin, Rhabdomyolysis [7]
methadone, methylergonovine, Gastrointestinal/Hepatic
ISRADIPINE methylprednisolone, methysergide, micafungin, Abdominal pain (2–6%) [5]
midazolam(oral), midostaurin, mifepristone, Constipation [2]
Trade name: DynaCirc (Reliant) mizolastine, naldemedine, neratinib, nevirapine, Diarrhea [4]
Indications: Hypertension nilotinib, nisoldipine, olaparib, omeprazole, oral Hepatitis [2]
Class: Calcium channel blocker hypoglycemics, osimertinib, paclitaxel, Hepatotoxicity [7]
Half-life: 8 hours palbociclib, paliperidone, pantoprazole, Nausea (5–7%) [8]
Clinically important, potentially hazardous pazopanib, phenobarbital, phenytoin, Pancreatitis [2]
interactions with: amprenavir, delavirdine, pimavanserin, pimecrolimus, pimozide, ponatinib, Vomiting [3]
epirubicin, imatinib, phenytoin prednisolone, prednisone, proton pump
Pregnancy category: C Respiratory
inhibitors, quetiapine, quinidine, ranolazine,
Cough (4%)
reboxetine, regorafenib, repaglinide, ribociclib,
Dyspnea (2%)
Skin rifabutin, rifampin, rilpivirine, rimonabant,
Edema (7%) [6] ritonavir, rivaroxaban, romidepsin, ruxolitinib,
Pneumonia (2%)
Exanthems (2%) [2] saquinavir, sildenafil, silodosin, simeprevir,
Pruritus (<6%) simvastatin, sirolimus, solifenacin, sonidegib, Endocrine/Metabolic
Rash (2%) sunitinib, tacrolimus, tadalafil, telaprevir, ALT increased [2]
telithromycin, temsirolimus, terfenadine, AST increased [2]
Mucosal Hyperbilirubinemia [2]
ticagrelor, tolterodine, tolvaptan, triamcinolone,
Oral lesions (6%) Hypertriglyceridemia [2]
triazolam, trimetrexate, ulipristal, valbenazine,
Cardiovascular vardenafil, vemurafenib, venetoclax, vinblastine, Hypokalemia [6]
Flushing (29%) [9] vincristine, vinflunine, vinorelbine, vorapaxar, Renal
QT prolongation [2] warfarin Renal failure [2]
Central Nervous System Pregnancy category: C
Hematologic
Headache (9%) Important contra-indications noted in the
Leukopenia [2]
Vertigo (dizziness) (9%) prescribing guidelines for: nursing mothers
Note: Contra-indicated in patients with evidence
of ventricular dysfunction such as congestive Other
heart failure (CHF) or a history of CHF except for Adverse effects [8]
ITRACONAZOLE the treatment of life-threatening or other serious Death [3]
infections. Side effects [2]
Trade names: Onmel (Merz), Sporanox
Warning: CONGESTIVE HEART FAILURE,
(Janssen)
CARDIAC EFFECTS AND DRUG
Indications: Onychomycosis, deep mycoses,
oropharyngeal candidiasis (oral solution only)
INTERACTIONS IVABRADINE
Class: Antibiotic, triazole, Antifungal, azole,
CYP3A4 inhibitor Skin Trade names: Corlanor (Amgen), Procoralan
Half-life: 21 hours AGEP [3] (Servier)
Clinically important, potentially hazardous Angioedema [2] Indications: Chronic stable angina pectoris
interactions with: abiraterone, afatinib, Diaphoresis (3%) Class: Cardiotonic agent, HCN channel blocker
alfentanil, alfuzosin, aliskiren, alprazolam, Edema (<4%) [11] Half-life: 2 hours
amphotericin B, amprenavir, anisindione, antacids, Exanthems (<3%) [7] Clinically important, potentially hazardous
aprepitant, aripiprazole, artemether/lumefantrine, Peripheral edema (4%) interactions with: azole antifungals,
astemizole, atazanavir, atorvastatin, avanafil, Phototoxicity [2] clarithromycin, CYP3A4 inducers, diltiazem,
boceprevir, bosentan, brigatinib, budesonide, Pruritus (<3%) [8] grapefruit juice, itraconazole, ketoconazole,
buspirone, busulfan, cabazitaxel, cabozantinib, Rash (8%) [10] macrolide antibiotics, nefazodone, nelfinavir,
calcifediol, calcium channel blockers, Urticaria [3] pentamidine, phenytoin, rifampin, ritonavir,
carbamazepine, cerivastatin, ciclesonide, sotalol, St John’s wort, strong or moderate
Hair
cilostazol, cimetidine, cinacalcet, cisapride, CYP3A4 inhibitors, telithromycin, verapamil
Alopecia [3]
clarithromycin, clopidogrel, clorazepate,
Mucosal
Xerostomia [3]
IVABRADINE Over 100 updates per week on www.drugeruptiondata.com
Pregnancy category: N/A Nasopharyngitis (15%) [4]

Important contra-indications noted in the Rhinitis (4–7%) IXAZOMIB
prescribing guidelines for: nursing mothers; Upper respiratory tract infection (22%) [7]
pediatric patients Wheezing (4–7%) Trade name: Ninlaro (Millennium)
Indications: Multiple myeloma (in combination
Endocrine/Metabolic with lenalidomide and dexamethasone) in patients
Cardiovascular AST increased (4–7%) who have received at least one prior therapy
Atrial fibrillation (8%) [3] Otic Class: Proteasome inhibitor
Atrioventricular block (<10%) Otitis media [2] Half-life: 10 days
Bradycardia (10%) [6] Clinically important, potentially hazardous
Hypertension (9%) Other
Adverse effects [4] interactions with: carbamazepine, phenytoin,
Central Nervous System rifampin, St John’s wort, strong CYP3A inducers
Headache (25%) [2] Pregnancy category: N/A (Can cause fetal
Vertigo (dizziness) (<10%) [3] harm)
IVERMECTIN Important contra-indications noted in the
Myalgia/Myopathy (<10%) prescribing guidelines for: nursing mothers;
Trade names: Sklice (Sanofi Pasteur), Soolantra pediatric patients
Gastrointestinal/Hepatic (Galderma), Stromectol (Merck) Note: See separate profiles for dexamethasone
Nausea [2] Indications: Various infections caused by and lenalidomide.
Ocular susceptible helmintic organisms
Luminous phenomena (14%) [5] Class: Anthelmintic
Half-life: 1635 hours Skin
Vision blurred (<10%) [3] Acneform eruption [3]
Visual disturbances [3] Clinically important, potentially hazardous
interactions with: alprazolam, barbiturates, Erythema [4]
benzodiazepines, diazepam, midazolam, valproic Erythema multiforme [2]
acid Exanthems [8]
IVACAFTOR Pregnancy category: C Exfoliative dermatitis [4]
Important contra-indications noted in the Facial edema [2]
Trade name: Kalydeco (Vertex) prescribing guidelines for: nursing mothers; Hyperhidrosis [4]
Indications: Cystic fibrosis in patients aged 6 pediatric patients Peripheral edema (25%) [4]
years and older who have a G551D mutation in Petechiae [3]
the CFTR gene Pigmentation [3]
Class: CFTR potentiator Skin Pruritus [4]
Half-life: 12 hours Edema (1053%) [7] Rash (19%) [10]
Clinically important, potentially hazardous Exanthems (<34%) [3] Urticaria [2]
interactions with: CYP3A inducers or Facial edema [3] Xerosis [3]
inhibitors, fluconazole, grapefruit juice, Pruritus (38–71%) [14]
Rash (<93%) [6] Hair
ketoconazole, rifampin, St John’s wort Alopecia [2]
Pregnancy category: B Urticaria (23%)
Important contra-indications noted in the Cardiovascular Central Nervous System
prescribing guidelines for: nursing mothers; Tachycardia (4%) Chills [2]
pediatric patients Fever [4]
Central Nervous System Insomnia [2]
Note: See also separate profile for lumacaftor/ Fever (23%) [2]
ivacaftor. Peripheral neuropathy (28%) [11]
Headache [3]
Psychosis [2] Neuromuscular/Skeletal
Skin Vertigo (dizziness) (3%) [3] Asthenia (fatigue) [10]
Acneform eruption (4–7%) Back pain (21%)
Rash (13%) [6] Arthralgia (9%) Gastrointestinal/Hepatic
Mucosal Myalgia/Myopathy (20%) [3] Abdominal pain [2]
Nasal congestion (20%) [7] Constipation (34%) [3]
Gastrointestinal/Hepatic Diarrhea (42%) [12]
Oropharyngeal pain (22%) [7] Abdominal pain [3] Nausea (26%) [11]
Cardiovascular Other Vomiting (22%) [10]
Chest pain (4–7%) Adverse effects [4] Respiratory
Central Nervous System Side effects (mild) [3] Dyspnea [2]
Fever [2] Pneumonia [3]
Headache (24%) [8] Upper respiratory tract infection (19%)
Vertigo (dizziness) (9%) [4] IXABEPILONE Endocrine/Metabolic
Neuromuscular/Skeletal Appetite decreased [4]
Arthralgia (4–7%) See: www.drugeruptiondata.com/drug/id/1255 Dehydration [3]
Myalgia/Myopathy (4–7%) Hypokalemia [2]
Gastrointestinal/Hepatic Renal
Abdominal pain (16%) [4] Renal failure [2]
Diarrhea (13%) [6]
Hepatotoxicity [3] Hematologic
Nausea (12%) [3] Anemia [8]
Vomiting [2] Leukopenia [3]
Lymphopenia [5]
Respiratory Neutropenia (67%) [11]
Cough [5] Platelets decreased [3]
Hemoptysis [2] Thrombocytopenia (78%) [16]
Litt’s Drug Eruption & Reaction Manual IXEKIZUMAB
Ocular Pregnancy category: N/A (Insufficient evidence Upper respiratory tract infection (14%) [9]
Conjunctivitis (6%) to inform drug-associated risk) Hematologic
Vision blurred (6%) Important contra-indications noted in the Neutropenia (11%) [3]
Xerophthalmia (5%) prescribing guidelines for: pediatric patients Thrombocytopenia (3%)
Other Otic
Adverse effects [4] Skin Ear infection (2%)
Peripheral edema [2] Local
Urticaria [2] Injection-site erythema [2]
IXEKIZUMAB Injection-site reactions (17%) [7]
Trade name: Taltz (Lilly) Headache [7] Other
Indications: Plaque psoriasis Infection [3]
Class: Interleukin-17A (IL-17A) antagonist, Crohn’s disease [2]
Monoclonal antibody Nausea (2%)
Half-life: 13 days
interactions with: live vaccines Nasopharyngitis [9]
JAPANESE ENCEPHALITIS VACCINE See all our books at www.crcpress.com
Pregnancy category: C Gastrointestinal/Hepatic

JAPANESE Important contra-indications noted in the Diarrhea (<10%)
prescribing guidelines for: nursing mothers; Nausea (<10%)
ENCEPHALITIS pediatric patients Vomiting (<10%)
VACCINE Respiratory
Skin Flu-like syndrome (12%)
Trade name: Ixiaro (Novartis) Edema (4%) Local
Indications: Active immunization against Pruritus (4%) Injection-site edema (<10%)
Japanese encephalitis for adults Rash (<10%) Injection-site erythema (<10%)
Class: Vaccine Central Nervous System Injection-site induration (<10%)
Half-life: N/A Fever [5] Injection-site pain (33%) [3]
Clinically important, potentially hazardous Headache (28%) [5] Injection-site pruritus (<10%)
interactions with: immunosuppressants Seizures [2] Other
Neuromuscular/Skeletal Adverse effects [5]
Litt’s Drug Eruption & Reaction Manual KETOPROFEN
Laryngospasm [4] triamcinolone, triazolam, trospium, ulipristal,

KANAMYCIN Genitourinary valbenazine, vardenafil, vemurafenib, venetoclax,
Cystitis [3] venlafaxine, vilazodone, vinblastine, vincristine,
Indications: Various infections caused by vorapaxar, warfarin, zaleplon, ziprasidone,
susceptible organisms Local zolpidem, zotarolimus
Class: Antibiotic, aminoglycoside Injection-site pain (<10%) Pregnancy category: C
Half-life: 24 hours Other Warning: HEPATOTXICITY, QT
Clinically important, potentially hazardous Adverse effects [3] PROLONGATION AND DRUG
interactions with: aldesleukin, atracurium, INTERACTIONS LEADING TO QT
bacitracin, bumetanide, doxacurium, ethacrynic PROLONGATION
acid, furosemide, methoxyflurane, neostigmine,
non-depolarizing muscle relaxants, pancuronium, KETOCONAZOLE
polypeptide antibiotics, rocuronium, Skin
succinylcholine, teicoplanin, torsemide, Trade name: Nizoral (Janssen) Anaphylactoid reactions/Anaphylaxis [3]
vecuronium Indications: Fungal infections Angioedema [3]
Pregnancy category: D Class: Antibiotic, imidazole, Antifungal, azole, Dermatitis [3]
Important contra-indications noted in the CYP3A4 inhibitor Exanthems (<9%) [7]
prescribing guidelines for: nursing mothers Half-life: initial: 2 hours; terminal: 8 hours Exfoliative dermatitis [2]
Note: Aminoglycosides may cause neurotoxicity Clinically important, potentially hazardous Fixed eruption [2]
and/or nephrotoxicity. interactions with: abemaciclib, abiraterone, Hypersensitivity [3]
afatinib, alcohol, alfuzosin, aliskiren, alitretinoin, Pigmentation [3]
almotriptan, alprazolam, amphotericin B, Pruritus (<9%) [5]
Skin amprenavir, anisindione, anticoagulants, Purpura [2]
Edema (>10%) aprepitant, aripiprazole, astemizole, atazanavir, Rash (<3%) [3]
Pruritus (<10%) avanafil, axitinib, beclomethasone, bedaquiline, Urticaria (<3%) [2]
Rash (<10%) benzodiazepines, betrixaban, boceprevir, Xerosis [3]
Renal bosentan, bosutinib, brentuximab vedotin, Hair
Nephrotoxicity [2] brigatinib, budesonide, buprenorphine, Alopecia (<4%) [4]
Otic cabazitaxel, cabozantinib, caffeine, calcifediol,
ceritinib, chlordiazepoxide, ciclesonide, cilostazol, Mucosal
Ototoxicity [8] Gingivitis [2]
cimetidine, cinacalcet, cisapride, clopidogrel,
clorazepate, cobicistat/elvitegravir/emtricitabine/ Oral lesions (<5%) [3]
tenofovir alafenamide, cobicistat/elvitegravir/ Oral lichenoid eruption [2]
KETAMINE emtricitabine/tenofovir disoproxil, colchicine, Oral pigmentation [2]
conivaptan, copanlisib, crizotinib, cyclosporine, Cardiovascular
Trade name: Ketalar (Monarch) cyproterone, dabigatran, darifenacin, darunavir, QT prolongation [4]
Indications: Induction of anesthesia dasatinib, desvenlafaxine, dexlansoprazole,
Class: Anesthetic Central Nervous System
dicumarol, didanosine, disopyramide, docetaxel, Chills (<3%)
Half-life: 23 hours dofetilide, domperidone, doxercalciferol,
Clinically important, potentially hazardous Fever [2]
dronedarone, dutasteride, echinacea, elbasvir & Neurotoxicity [3]
interactions with: memantine, mivacurium grazoprevir, eletriptan, eplerenone, erlotinib,
Pregnancy category: D erythromycin, estradiol, eszopiclone, everolimus, Neuromuscular/Skeletal
fentanyl, fesoterodine, fingolimod, flibanserin, Asthenia (fatigue) [3]
Skin flunisolide, fluticasone propionate, fosamprenavir, Rhabdomyolysis [3]
Pruritus [3] gastric alkanizers, halofantrine, HMG-CoA Gastrointestinal/Hepatic
Rash (<10%) reductase inhibitors, ibrutinib, iloperidone, Hepatotoxicity [18]
imatinib, indacaterol, indinavir, irinotecan, Nausea (3–10%) [4]
Mucosal
isavuconazonium sulfate, ivabradine, ivacaftor, Vomiting (3–10%)
Sialorrhea [2]
ixabepilone, lanthanum, lapatinib, Endocrine/Metabolic
Cardiovascular levomilnacipran, lomitapide, lopinavir, lurasidone,
Bradycardia [4] Gynecomastia (<3%) [8]
macitentan, maraviroc, mefloquine, methadone,
Hypertension [5] methylergonovine, methylprednisolone, Hematologic
Hypotension [5] midazolam, midostaurin, mizolastine, Eosinophilia [2]
Tachycardia [2] mometasone, naldemedine, neratinib, nevirapine, Other
Central Nervous System nilotinib, nisoldipine, non-sedating antihistamines, Adverse effects [5]
Agitation [5] olaparib, omeprazole, ospemifene, oxybutynin, Death [5]
Amnesia [2] paclitaxel, palbociclib, pantoprazole, paricalcitol,
Hallucinations [14] pazopanib, pimavanserin, pimecrolimus,
pimozide, pomalidomide, ponatinib,
Headache [3]
Mania [2] prednisolone, prednisone, proton-pump
KETOPROFEN
Nightmares [2] inhibitors, quetiapine, quinidine, rabeprazole,
Trade names: Orudis (Sanofi-Aventis), Oruvail
Sedation [3] ramelteon, ranolazine, reboxetine, regorafenib,
(Wyeth)
Tremor (>10%) ribociclib, rifampin, rilpivirine, rimonabant,
Indications: Arthritis
Vertigo (dizziness) [4] ritonavir, rivaroxaban, roflumilast, romidepsin,
Class: Non-steroidal anti-inflammatory (NSAID)
ropivacaine, rupatadine, ruxolitinib, saquinavir,
Gastrointestinal/Hepatic Half-life: 1.54 hours
saxagliptin, sildenafil, silodosin, simeprevir,
Hepatotoxicity [2] Clinically important, potentially hazardous
simvastatin, solifenacin, sonidegib, sucralfate,
Nausea [7] interactions with: aspirin, caffeine,
sunitinib, tacrolimus, tadalafil, tamsulosin,
Vomiting [11] methotrexate, probenecid
tasimelteon, telaprevir, telithromycin,
Respiratory temsirolimus, ticagrelor, tiotropium, tofacitinib,
Apnea [3] tolterodine, tolvaptan, trabectedin, tramadol,
Hypoxia [3]
KETOPROFEN Over 100 updates per week on www.drugeruptiondata.com
Pregnancy category: C Other Cardiovascular

Important contra-indications noted in the Adverse effects [11] Hypertension (<10%)
prescribing guidelines for: nursing mothers; Allergic reactions [2] Central Nervous System
pediatric patients Headache (>10%) [4]
Note: NSAIDs may cause an increased risk of Somnolence (drowsiness) [3]
serious cardiovascular and gastrointestinal
adverse events, which can be fatal. This risk may
KETOROLAC Vertigo (dizziness) [4]
increase with duration of use. Gastrointestinal/Hepatic
Trade names: Acular (Allergan), Toradol (Roche) Abdominal pain (>10%)
Indications: Pain, relief of inflammation following Constipation (<10%)
Skin cataract surgery (ophthalmic solution) Diarrhea (7%) [2]
Anaphylactoid reactions/Anaphylaxis [4] Class: Analgesic, non-opioid, Non-steroidal anti- Dyspepsia (>10%)
Contact dermatitis [5] inflammatory (NSAID) Flatulence (<10%)
Dermatitis [29] Half-life: 28 hours Gastrointestinal bleeding [6]
Eczema [3] Clinically important, potentially hazardous Gastrointestinal ulceration (<10%) [2]
Erythema [4] interactions with: aspirin, buprenorphine, Nausea (>10%) [12]
Exanthems [3] dabigatran, diclofenac, enoxaparin, meloxicam, Vomiting (<10%) [8]
Peripheral edema (<3%) methotrexate, probenecid, rivaroxaban,
Photoallergic reaction [2] salicylates, tiagabine, tinzaparin Renal
Photocontact dermatitis [5] Pregnancy category: C Renal function abnormal (<10%)
Photosensitivity [35] Important contra-indications noted in the Hematologic
Pruritus (<10%) [4] prescribing guidelines for: nursing mothers; Anemia (<10%)
Rash (>10%) pediatric patients Prothrombin time increased (<10%)
Urticaria [6] Warning: GASTROINTESTINAL, Otic
Gastrointestinal/Hepatic CARDIOVASCULAR, RENAL, AND BLEEDING
Tinnitus (<10%)
Abdominal pain (3–9%) [2] RISK
Ocular
Constipation [2]
Corneal melting [4]
Diarrhea (3–9%) Skin Ocular burning [2]
Dyspepsia (11%) [2] Anaphylactoid reactions/Anaphylaxis [3]
Gastrointestinal bleeding [2] Dermatitis (39%) Local
Nausea (3–9%) [2] Diaphoresis (<10%) [2] Injection-site pain (<10%)
Pancreatitis [3] Edema (<10%) Other
Endocrine/Metabolic Exanthems (39%) Adverse effects [10]
Pseudoporphyria [2] Hematoma [2] Death [2]
Hypersensitivity [2] Side effects [2]
Renal Pruritus (<10%)
Renal function abnormal (3–9%) Purpura (<10%)
Local Rash (<10%)
Application-site reactions [2]
KETOTIFEN
Mucosal
Stomatitis (<10%) See: www.drugeruptiondata.com/drug/id/385
Xerostomia [2]
Litt’s Drug Eruption & Reaction Manual LAMOTRIGINE
Pregnancy category: C Pregnancy category: C

L-CARNITINE Important contra-indications noted in the Note: Combivir is lamivudine and zidovudine;
prescribing guidelines for: the elderly; nursing Epzicom is lamivudine and abacavir; Triumeq is
See: www.drugeruptiondata.com/drug/id/914 mothers; pediatric patients abacavir, dolutegravir and lamivudine; Trizivir is
lamivudine, abacavir and zidovudine,.
Skin
L-METHYLFOLATE Angioedema [2] Skin
Pruritus (2%) Angioedema [2]
See: www.drugeruptiondata.com/drug/id/1299 Rash [2] Exanthems [2]
Cardiovascular Hypersensitivity [4]
Atrioventricular block [3] Jaundice [2]
LABETALOL Hypotension [2] Pigmentation [2]
Pruritus [3]
Trade name: Trandate (Prometheus) Central Nervous System Rash (9%) [10]
Indications: Hypertension Balance disorder (4%) Stevens-Johnson syndrome [2]
Class: Adrenergic beta-receptor antagonist, Depression (2%) [2] Toxic epidermal necrolysis [2]
Antiarrhythmic class II Gait instability (2%) [4]
Headache (13%) [14] Hair
Half-life: 38 hours Alopecia [3]
Clinically important, potentially hazardous Incoordination [2]
interactions with: cimetidine, halothane, Irritability [2] Central Nervous System
imipramine, iobenguane, tricyclic antidepressants Memory loss (2%) Abnormal dreams [2]
Pregnancy category: C Sedation [3] Chills (<10%)
Important contra-indications noted in the Seizures [4] Headache [6]
prescribing guidelines for: nursing mothers; Somnolence (drowsiness) (7%) [10] Insomnia [3]
pediatric patients Tremor (7%) [4] Neurotoxicity [2]
Note: Cutaneous side effects of beta-receptor Vertigo (dizziness) (31%) [34] Paresthesias (>10%)
blockers are clinically polymorphous. They Neuromuscular/Skeletal Peripheral neuropathy [3]
apparently appear after several months of Asthenia (fatigue) (2–9%) [8] Vertigo (dizziness) [4]
continuous therapy. Ataxia (8%) [9] Neuromuscular/Skeletal
Gastrointestinal/Hepatic Asthenia (fatigue) [5]
Skin Diarrhea (4%) Myalgia/Myopathy (8%)
Anaphylactoid reactions/Anaphylaxis [2] Nausea (11%) [17] Rhabdomyolysis [3]
Edema (<2%) Pancreatitis [2] Gastrointestinal/Hepatic
Exanthems (<5%) [4] Vomiting (9%) [8] Abdominal pain [4]
Lichenoid eruption [4] Respiratory Diarrhea [4]
Lupus erythematosus [4] Nasopharyngitis [2] Hepatotoxicity [3]
Pityriasis rubra pilaris [2] Upper respiratory tract infection [2] Nausea [6]
Pruritus (<10%) [3] Pancreatitis [4]
Psoriasis (exacerbation) [3] Ocular Vomiting [2]
Scalp tingling [3] Abnormal vision [3]
Diplopia (11%) [13] Respiratory
Cardiovascular Nystagmus (5%) Upper respiratory tract infection [2]
Flushing (19%) Vision blurred (8%) [4] Endocrine/Metabolic
Hypotension [4] Acidosis [3]
Local
Central Nervous System Injection-site pain (2%) Hematologic
Dysgeusia (taste perversion) (<10%) Anemia [2]
Paresthesias (7%) [2] Other
Adverse effects [8] Other
Neuromuscular/Skeletal Adverse effects [9]
Other LACTULOSE
Side effects (6%) [2] LAMOTRIGINE
Trade name: Lamictal (GSK)
LACOSAMIDE Indications: Epilepsy
Trade name: Vimpat (UCB Pharma)

LAMIVUDINE Class: Anticonvulsant, Antiepileptic, Mood
stabilizer
Indications: Partial-onset seizures Synonym: 3TC Half-life: 24 hours
Class: Anticonvulsant, Antiepileptic Trade names: Combivir (ViiV), Epivir (ViiV), Clinically important, potentially hazardous
Half-life: 13 hours Epzicom (ViiV), Triumeq (ViiV), Trizivir (ViiV) interactions with: eslicarbazepine, lacosamide,
Clinically important, potentially hazardous Indications: HIV progression oral contraceptives, rufinamide
interactions with: alcohol, antipsychotics, Class: Antiretroviral, Nucleoside analog reverse Pregnancy category: C
carbamazepine, chloroquine, fosphenytoin, transcriptase inhibitor Important contra-indications noted in the
hydroxychloroquine, lamotrigine, MAO Half-life: 57 hours prescribing guidelines for: the elderly; nursing
inhibitors, mefloquine, orlistat, phenobarbital, Clinically important, potentially hazardous mothers
phenytoin, pregabalin, SSRIs, St John’s wort, interactions with: cobicistat/elvitegravir/ Warning: SERIOUS SKIN RASHES
tricyclic antidepressants emtricitabine/tenofovir disoproxil, emtricitabine,
trimethoprim Skin
Angioedema (<10%)
LAMOTRIGINE See all our books at www.crcpress.com
Anticonvulsant hypersensitivity syndrome Side effects [2] Pregnancy category: C

[17] Teratogenicity [6] Important contra-indications noted in the
DRESS syndrome [17] prescribing guidelines for: nursing mothers
Erythema (<10%) [2]
Exanthems (<10%) [18]
LANREOTIDE Skin
Hot flashes (<10%) Trade names: Somatuline Autogel (Ipsen), Erythema multiforme [2]
Hypersensitivity (<10%) [29] Somatuline Depot (Ipsen), Somatuline LA (Ipsen) Facial edema [2]
Lupus erythematosus [4] Indications: Acromegaly, carcinoid syndrome, Hypersensitivity [3]
Photosensitivity [2] thyrotrophic adenoma Lupus erythematosus [3]
Pruritus (3%) [3] Class: Somatostatin analog Peripheral edema [2]
Rash (1020%) [53] Half-life: 2 hours (immediate release) 5 days Pruritus (310%)
Stevens-Johnson syndrome (<10%) [49] (sustained release). Rash (310%)
Toxic epidermal necrolysis [51] Clinically important, potentially hazardous Toxic epidermal necrolysis [4]
Hair interactions with: antidiabetics, bromocriptine, Urticaria [3]
Alopecia [2] cyclosporine, insulin, metformin, repaglinide, Mucosal
Mucosal sulfonylureas Stomatitis [2]
Xerostomia (6%) Pregnancy category: C
Central Nervous System prescribing guidelines for: nursing mothers; Dysgeusia (taste perversion) [3]
Agitation [2] pediatric patients Headache (3%) [4]
Aseptic meningitis [4] Vertigo (dizziness) [2]
Fever [2] Gastrointestinal/Hepatic
Hallucinations [3] Hair
Alopecia [2] Abdominal pain [2]
Headache [6] Colitis [2]
Insomnia (5–10%) Cardiovascular Constipation [2]
Nervousness [2] Bradycardia (518%) Diarrhea (<5%) [6]
Neuroleptic malignant syndrome [2] Hypertension (5%) Hepatitis [2]
Pain (5%) Central Nervous System Nausea [2]
Seizures [9] Headache (7%)
Somnolence (drowsiness) (9%) [7] Endocrine/Metabolic
Pain (7%) Gynecomastia [2]
Suicidal ideation [2]
Tic disorder [2] Neuromuscular/Skeletal Other
Tremor [4] Arthralgia (7%) [2] Death [2]
Vertigo (dizziness) [8] Gastrointestinal/Hepatic
Neuromuscular/Skeletal Abdominal pain (719%) [6]
Asthenia (fatigue) (8%) [2] Cholelithiasis (gallstones) (2–17%) [2] LANTHANUM
Ataxia (2–5%) [3] Constipation (8%)
Rhabdomyolysis [3] Diarrhea (31–65%) [6] See: www.drugeruptiondata.com/drug/id/1113
Flatulence (6–14%) [3]
Gastrointestinal/Hepatic Loose stools (6%)
Abdominal pain (6%) Nausea (11%) [3]
Hepatotoxicity [4] Steatorrhea [2] LAPATINIB
Nausea [4] Vomiting (7%)
Respiratory Trade name: Tykerb (Novartis)
Endocrine/Metabolic Indications: Breast cancer
Cough (5%) Diabetes mellitus (7%)
Flu-like syndrome (7%) Class: Antineoplastic, Biologic, Epidermal growth
Hyperglycemia (7%) factor receptor (EGFR) inhibitor, Tyrosine kinase
Pharyngitis (5%) Hypoglycemia (7%)
Rhinitis (7%) inhibitor
Weight loss (511%) Half-life: 24 hours
Endocrine/Metabolic Hematologic Clinically important, potentially hazardous
SIADH [2] Anemia (5–14%) interactions with: alfuzosin, artemether/
Genitourinary Local lumefantrine, atazanavir, carbamazepine,
Urinary frequency (<5%) Injection-site induration [3] chloroquine, ciprofloxacin, clarithromycin,
Vaginitis (4%) Injection-site pain (4%) [4] clozapine, colchicine, conivaptan, CYP2C8
Renal Injection-site reactions (622%) [2] substrates, CYP3A4 inhibitors or inducers,
Nephrotoxicity [3] dabigatran, deferasirox, dexamethasone, digoxin,
Other docetaxel, dronedarone, efavirenz, eplerenone,
Hematologic Adverse effects [2] everolimus, fentanyl, food, gadobutrol, grapefruit
Agranulocytosis [3] juice, histamine H2-antagonists, indinavir,
Ocular irinotecan, itraconazole, ketoconazole,
Abnormal vision (2–5%) LANSOPRAZOLE nefazodone, nelfinavir, nilotinib, omeprazole, P-
Diplopia [5] glycoprotein inducers, paclitaxel, pantoprazole,
Hallucinations, visual [2] Trade name: Prevacid (TAP) pazopanib, phenobarbital, phenytoin,
Nystagmus (2–5%) Indications: Active duodenal ulcer pimecrolimus, pimozide, posaconazole, proton
Class: Proton pump inhibitor (PPI) pump inhibitors, QT prolonging agents, quinine,
Other
Half-life: 2 hours repaglinide, rifabutin, rifampin, rifapentin,
Adverse effects [7]
Clinically important, potentially hazardous ritonavir, rivaroxaban, safinamide, salmeterol,
interactions with: bosutinib, clopidogrel, saquinavir, saxagliptin, silodosin, St John’s wort,
Death [6]
delavirdine, eucalyptus, neratinib, prednisone, telithromycin, tetrabenazine, thioridazine,
Multiorgan failure [2]
rilpivirine, sucralfate tolvaptan, topotecan, voriconazole, ziprasidone
Litt’s Drug Eruption & Reaction Manual LEFLUNOMIDE
Important contra-indications noted in the LATANOPROST LEDIPASVIR &
pediatric patients Trade name: Xalatan (Pfizer) SOFOSBUVIR
Note: Lapitinib is used in conjunction with Indications: Reduction of elevated intraocular
pressure in open angle glaucoma or ocular Trade name: Harvoni (Gilead)
capecitabine.
hypertension Indications: Hepatitis C
Warning: HEPATOXICITY
Class: Prostaglandin analog Class: Hepatitis C virus NS5A inhibitor
Half-life: 17 minutes (ledipasvir), Hepatitis C virus nucleotide analog
Skin Clinically important, potentially hazardous NS5B polymerase inhibitor (sofosbuvir)
Acneform eruption (90%) [4] interactions with: thimerosal Half-life: 47 hours (ledipasvir); <27 hours
Depigmentation (21%) Pregnancy category: C (sofosbuvir)
Hand–foot syndrome (53%) [9] Important contra-indications noted in the Clinically important, potentially hazardous
Inflammation (15%) prescribing guidelines for: nursing mothers; interactions with: amiodarone, carbamazepine,
Pruritus [3] pediatric patients cobicistat/elvitegravir/emtricitabine/tenofovir
Rash (28%) [26] disoproxil, oxcarbazepine, phenobarbital,
Toxicity [6] phenytoin, rifabutin, rifampin, rifapentine,
Xerosis (10%) Skin ritonavir, rosuvastatin, simeprevir, St John’s wort,
Pigmentation [2] tenofovir disoproxil
Hair Pruritus [2]
Alopecia [2] Pregnancy category: N/A (Insufficient evidence
Rash (<10%) to inform drug-associated risk; contra-indicated in
Nails Cardiovascular pregnancy when given with ribavirin )
Paronychia [3] Angina (<10%) Important contra-indications noted in the
Mucosal Chest pain (<10%) prescribing guidelines for: nursing mothers;
Mucosal inflammation (15%) Central Nervous System pediatric patients
Mucositis [2] Headache [3] Note: See also separate entry for sofosbuvir.
Stomatitis (14%) Vertigo (dizziness) [2]
Central Nervous System Neuromuscular/Skeletal Skin
Anorexia (24%) [2] Arthralgia (<10%) Pruritus [6]
Insomnia (10%) Back pain (<10%) Rash [5]
Neuromuscular/Skeletal Myalgia/Myopathy (<10%) Cardiovascular
Asthenia (fatigue) (12%) [19] Respiratory Bradycardia [3]
Back pain (11%) Flu-like syndrome (<10%) Central Nervous System
Bone or joint pain [2] Upper respiratory tract infection (<10%) Headache (11–17%) [32]
Pain in extremities (12%)
Ocular Insomnia (3–6%) [11]
Gastrointestinal/Hepatic Conjunctival hyperemia [19] Irritability [5]
Abdominal pain (15%) Deepening of upper lid sulcus [5] Vertigo (dizziness) [3]
Diarrhea (65%) [44] Eyelashes – hypertrichosis [15] Neuromuscular/Skeletal
Dyspepsia (11%) Eyelashes – pigmentation [9] Arthralgia [3]
Hepatotoxicity [11] Eyelid edema (<4%) Asthenia (fatigue) (7–18%) [33]
Nausea (44%) [9] Eyelid erythema (<4%) Muscle spasm [2]
Vomiting (26%) [7] Eyelid pain (<10%) Myalgia/Myopathy [3]
Respiratory Eyelid pigmentation [4] Gastrointestinal/Hepatic
Dyspnea (12%) [2] Eyelid pruritus (2%) Diarrhea (3–7%) [12]
Endocrine/Metabolic Foreign body sensation [5] Hepatotoxicity [3]
ALT increased (37%) [5] Iris pigmentation [7] Nausea (6–9%) [20]
AST increased (49%) [4] Keratitis [3]
Macular edema [7] Respiratory
Hyperbilirubinemia [3]
Ocular adverse effects [7] Cough [3]
Hematologic Ocular hyperemia [4] Dyspnea [3]
Anemia [5] Ocular itching [8] Nasopharyngitis [2]
Febrile neutropenia [2] Ocular pigmentation (5%) [12] Upper respiratory tract infection [6]
Leukopenia [4] Periorbitopathy [2] Renal
Lymphopenia [2] Uveitis [5] Nephrotoxicity [3]
Neutropenia [8] Vision blurred [3]
Hematologic
Otic Xerophthalmia (<10%)
Anemia [7]
Tinnitus (14%) Other
Other
Other Allergic reactions (<10%)
Adverse effects [5]
Infection [2]
Death [2]
LARONIDASE LEFLUNOMIDE
LENALIDOMIDE Over 100 updates per week on www.drugeruptiondata.com
Vertigo (dizziness) (20%) Death [4]

LENALIDOMIDE Neuromuscular/Skeletal Infection [20]
Arthralgia (21%) [4] Teratogenicity [2]
Trade name: Revlimid (Celgene)
Indications: Transfusion-dependent anemia due Asthenia (fatigue) (15–31%) [33]
to myeloplastic syndromes, multiple myeloma (in Back pain (21%) [4]
combination with dexamethasone) Bone or joint pain (14%) LENVATINIB
Class: Biologic, Immunomodulator, Thalidomide Cramps (33%)
analog Muscle spasm [4] Trade name: Lenvima (Eisai)
Half-life: 3–5 hours Myalgia/Myopathy (18%) [3] Indications: Differentiated thyroid cancer, renal
Clinically important, potentially hazardous Pain in extremities (12%) cell cancer (in combination with everolimus)
interactions with: abatacept, anakinra, Gastrointestinal/Hepatic Class: Tyrosine kinase inhibitor
canakinumab, certolizumab, denosumab, Abdominal pain (8–12%) Half-life: 28 hours
dexamethasone, digoxin, erythropoietin Constipation (24%) [8] Clinically important, potentially hazardous
stimulating agents, estrogen containing therapies, Diarrhea (49%) [15] interactions with: none known
leflunomide, natalizumab, pimecrolimus, Gastrointestinal disorder [4] Pregnancy category: N/A (Can cause fetal
rilonacept, sipuleucel-T, tacrolimus, trastuzumab, Hepatotoxicity [3] harm)
vaccines Loose stools (6%) Important contra-indications noted in the
Pregnancy category: X Nausea (24%) [9] prescribing guidelines for: nursing mothers;
Important contra-indications noted in the Vomiting (10%) [5] pediatric patients
prescribing guidelines for: nursing mothers; Respiratory
pediatric patients Acute respiratory distress syndrome [2] Skin
Warning: FETAL RISK, HEMATOLOGIC Alveolar hemorrhage (pulmonary) [2] Exanthems (21%)
TOXICITY, and DEEP VEIN THOMBOSIS AND Bronchitis (11%) Hand–foot syndrome (32%) [2]
PULMONARY EMBOLISM Cough (20%) [5] Hyperkeratosis (7%)
Dyspnea (7–17%) [4] Peripheral edema (21%) [3]
Skin Nasopharyngitis (23%) Rash (21%)
Cellulitis (5%) Pharyngitis (16%) Toxicity [2]
DRESS syndrome [2] Pneumonia (12%) [9] Hair
Ecchymoses (5–8%) Pneumonitis [7] Alopecia (12%)
Edema (10%) Pulmonary toxicity [3] Mucosal
Erythema (5%) Rhinitis (7%) Aphthous stomatitis (41%)
Exanthems [3] Sinusitis (8%) Epistaxis (nosebleed) (12%)
Folliculitis [2] Upper respiratory tract infection (15%) [3] Gingivitis (10%)
Graft-versus-host reaction [2] Endocrine/Metabolic Glossitis (41%)
Hyperhidrosis (7%) [2] ALT increased (8%) [3] Glossodynia (25%)
Malignancies (secondary) [6] Appetite decreased (7%) Mucosal inflammation (41%)
Peripheral edema (26%) [4] Hyperglycemia [2] Oral ulceration (41%)
Pigmentation [2] Hypocalcemia (9%) Oropharyngeal pain (25%)
Pruritus (42%) [3] Hypokalemia (11%) [4] Parotitis (10%)
Rash (36%) [16] Hypomagnesemia (6%) Stomatitis (41%) [3]
Stevens-Johnson syndrome [5] Hyponatremia [2] Xerostomia (17%)
Sweet’s syndrome [3] Hypophosphatemia [3]
Toxicity [6] Cardiovascular
Hypothyroidism (7%) Hypertension (73%) [18]
Tumor lysis syndrome [3] Weight loss (20%)
Tumors [5] Hypotension (9%)
Xerosis (14%) [2] Genitourinary QT prolongation (9%)
Urinary tract infection (11%) Central Nervous System
Mucosal
Epistaxis (nosebleed) (15%) Renal Anorexia [3]
Xerostomia (7%) Nephrotoxicity [3] Dysgeusia (taste perversion) (18%)
Hematologic Headache (38%) [4]
Cardiovascular Insomnia (12%)
Chest pain (5%) Anemia (31%) [25]
Cytopenia [3] Vertigo (dizziness) (15%)
Hypertension (6%)
Palpitation (5%) Febrile neutropenia (5%) [8] Neuromuscular/Skeletal
Thromboembolism [5] Hemotoxicity [12] Arthralgia (62%)
Venous thromboembolism [13] Leukopenia (8%) [11] Asthenia (fatigue) (67%) [10]
Lymphopenia (5%) [8] Back pain (62%)
Central Nervous System Myelosuppression [6] Bone or joint pain (62%)
Anorexia (10%) Neutropenia (59%) [58] Myalgia/Myopathy (62%)
Depression (5%) Thrombocytopenia (62%) [50] Pain in extremities (62%)
Dysgeusia (taste perversion) (6%) Thrombosis [4]
Fever (21%) [3] Gastrointestinal/Hepatic
Headache (20%) Ocular Abdominal pain (31%) [2]
Hypoesthesia (7%) Vision blurred (17%) Constipation (29%) [3]
Insomnia (10%) [4] Local Diarrhea (67%) [11]
Neurotoxicity (7%) [8] Infusion-related reactions [2] Dyspepsia (13%)
Pain (7%) Injection-site reactions [2] Nausea (47%) [7]
Peripheral neuropathy (5%) [12] Vomiting (36%) [5]
Other
Rigors (6%) Adverse effects [13] Respiratory
Somnolence (drowsiness) [2] Cancer [2] Cough (24%)
Tremor (21%) Dysphonia (31%) [2]
Litt’s Drug Eruption & Reaction Manual LEUCOVORIN
Nasopharyngitis [2] Vertigo (dizziness) [2] Endocrine/Metabolic

Endocrine/Metabolic Neuromuscular/Skeletal Hypercholesterolemia [3]
ALP increased (>5%) Back pain [2] Hyperglycemia [3]
ALT increased (4%) [2] Gastrointestinal/Hepatic Genitourinary
Appetite decreased (54%) [6] Diarrhea [2] Vaginal dryness [4]
AST increased (5%) [2] Gastroesophageal reflux (3%) Hematologic
Creatine phosphokinase increased (3%) Leukopenia [2]
Dehydration (9%) Respiratory
Influenza (5%) Neutropenia [4]
Hyperbilirubinemia (>5%)
Hypercalcemia (>5%) Nasopharyngitis [2] Other
Hypercholesterolemia (>5%) Endocrine/Metabolic Adverse effects [2]
Hyperkalemia (>5%) Serum creatinine increased (4–8%) [2] Infection [2]
Hypoalbuminemia (>5%) Renal
Hypocalcemia (9%) Nephrolithiasis (<3%)
Hypoglycemia (>5%) Renal failure (<4%) LEUCOVORIN
Hypokalemia (6%)
Hypomagnesemia (>5%) Synonyms: citrovorum factor; folinic acid
Weight loss (51%) [5] Indications: Overdose of methotrexate, in
Genitourinary
LETROZOLE combination with fluorouracil in the palliative
Hematuria [2] treatment of patients with colorectal cancer
Trade name: Femara (Novartis) Class: Adjuvant
Urinary tract infection (11%) Indications: Breast cancer Half-life: 15 minutes
Renal Class: Aromatase inhibitor Clinically important, potentially hazardous
Proteinuria (34%) [9] Half-life: ~2 days interactions with: capecitabine, glucarpidase,
Hematologic Clinically important, potentially hazardous trimethoprim
Leukopenia [2] interactions with: none known Pregnancy category: C
Platelets decreased (2%) Pregnancy category: X
Thrombocytopenia [4] Important contra-indications noted in the
prescribing guidelines for: nursing mothers; Skin
Other pediatric patients Hand–foot syndrome [3]
Adverse effects [3] Rash [5]
Death [2] Toxicity [2]
Tooth disorder (10%) Skin
Exanthems (5%) Hair
Hot flashes (6%) [8] Alopecia [2]
Hyperhidrosis (<5%) Mucosal
LEPIRUDIN Leukocytoclastic vasculitis [2] Mucositis [6]
Pruritus (2%) Stomatitis [5]
See: www.drugeruptiondata.com/drug/id/2145 Psoriasis (5%) Cardiovascular
Rash (<10%) [5] Hypertension [6]
Vesiculation (5%)
LESINURAD Hair
Anorexia [5]
Alopecia (<5%) [3] Neurotoxicity [5]
Trade names: Duzallo (AstraZeneca), Zurampic
(AstraZeneca) Cardiovascular Peripheral neuropathy [4]
Indications: Gout-associated hyperuricemia (in Cardiac failure [2] Neuromuscular/Skeletal
combination with a xanthine oxidase inhibitor) Hypertension [3] Asthenia (fatigue) [8]
Class: URAT1 inhibitor Myocardial toxicity [2]
Half-life: 5 hours Central Nervous System Abdominal pain [2]
Clinically important, potentially hazardous Anorexia [3] Diarrhea [22]
interactions with: amiodarone, carbamazepine, Depression [3] Nausea [13]
CYP2C9 inducers or inhibitors, CYP3A Fever [2] Vomiting [11]
substrates, fluconazole, rifampin, valproic acid Headache [3]
Pregnancy category: N/A (No available data) Insomnia [2] Endocrine/Metabolic
Important contra-indications noted in the Mood changes [2] ALP increased [2]
prescribing guidelines for: nursing mothers; Vertigo (dizziness) [2] Renal
pediatric patients Neuromuscular/Skeletal Proteinuria [3]
Note: Contra-indicated in patients with severe
Arthralgia [10] Hematologic
renal impairment (including end stage renal
Asthenia (fatigue) [9] Anemia [9]
disease, kidney transplant recipients or patients
Back pain [3] Febrile neutropenia [3]
on dialysis), tumor lysis syndrome or Lesch-Nylan
Bone or joint pain [3] Leukopenia [6]
syndrome. Duzallo is lesinurad and allopurinol
Myalgia/Myopathy [7] Neutropenia [24]
(see separate entry).
Osteoporosis [7] Thrombocytopenia [6]
Warning: RISK OF ACUTE RENAL FAILURE,
MORE COMMON WHEN USED WITHOUT A Gastrointestinal/Hepatic Other
XANTHINE OXIDASE INHIBITOR Constipation [2] Adverse effects [2]
Diarrhea [7] Infection [2]
Nausea [8]
Cardiovascular Vomiting [4]
Cardiotoxicity (<2%)
Respiratory
Central Nervous System Dyspnea [3]
Headache (5%) [2]
LEUPROLIDE See all our books at www.crcpress.com
Other
LEUPROLIDE LEVETIRACETAM Adverse effects [8]
Death [2]
Trade names: Eligard (Sanofi-Aventis), Lupron Trade names: Elepsia XR (Sun Pharma), Keppra Infection (1326%) [7]
(TAP), Lupron Depot-Ped (AbbVie), Viadur (UCB)
(Bayer) Indications: Partial onset seizures
Indications: Prostate carcinoma, endometriosis Class: Anticonvulsant
Class: Gonadotropin-releasing hormone (GnRH) Half-life: 7 hours LEVOBETAXOLOL
agonist Clinically important, potentially hazardous
Half-life: 34 hours interactions with: carbamazepine, See: www.drugeruptiondata.com/drug/id/767
Clinically important, potentially hazardous eslicarbazepine
interactions with: none known Pregnancy category: C
Pregnancy category: X Important contra-indications noted in the LEVOBUNOLOL
Important contra-indications noted in the prescribing guidelines for: nursing mothers
prescribing guidelines for: nursing mothers See: www.drugeruptiondata.com/drug/id/397
Skin
Skin DRESS syndrome [7]
Anaphylactoid reactions/Anaphylaxis [3] Erythema [2] LEVOBUPIVACAINE
Dermatitis (5%) Erythema multiforme [2]
Dermatitis herpetiformis [2] Rash [5] See: www.drugeruptiondata.com/drug/id/922
Ecchymoses (<5%) Stevens-Johnson syndrome [3]
Edema (<10%) Toxic epidermal necrolysis [2]
Granulomas [2]
Hot flashes (12%) [6]
Urticaria [2] LEVOCETIRIZINE
Peripheral edema (412%) Aggression [7] Trade name: Xyzal (UCB Pharma)
Pigmentation (<5%) Agitation [5] Indications: Allergic rhinitis, chronic idiopathic
Pruritus (<5%) Anorexia [2] urticaria
Rash (<10%) Behavioral disturbances [4] Class: Histamine H1 receptor antagonist
Vasculitis [2] Compulsions [2] Half-life: 6–10 hours
Xerosis (<5%) Depression [8] Clinically important, potentially hazardous
Hair Encephalopathy [4] interactions with: none known
Alopecia (<5%) Fever [2] Pregnancy category: B
Cardiovascular Headache (25%) [12] Important contra-indications noted in the
Flushing (61%) [2] Irritability [9] prescribing guidelines for: the elderly; nursing
Thrombophlebitis (2%) Nervousness [2] mothers; pediatric patients
Neurotoxicity [3]
Central Nervous System Paresthesias (2%)
Dysgeusia (taste perversion) (<5%) Skin
Psychosis [3] Fixed eruption [3]
Paresthesias (<5%) Seizures [4]
Neuromuscular/Skeletal Sleep related disorder [2] Mucosal
Myalgia/Myopathy [2] Somnolence (drowsiness) [17] Xerostomia (2–3%)
Endocrine/Metabolic Suicidal ideation [4] Central Nervous System
Gynecomastia (7%) Vertigo (dizziness) (918%) [20] Headache [2]
Mastodynia (7%) Neuromuscular/Skeletal Sedation [2]
Asthenia (fatigue) (<22%) [20] Somnolence (drowsiness) (5–6%)
Ocular
Diplopia [2] Osteoporosis [2] Neuromuscular/Skeletal
Rhabdomyolysis [3] Asthenia (fatigue) (<4%)
Local
Injection-site granuloma [6] Gastrointestinal/Hepatic Gastrointestinal/Hepatic
Injection-site inflammation (2%) Abdominal pain [2] Hepatotoxicity [2]
Injection-site pain [2] Diarrhea [2] Respiratory
Injection-site reactions (24%) Hepatotoxicity [3] Nasopharyngitis (4–6%)
Nausea [4] Pharyngitis (<2%)
Vomiting [4]
LEVALBUTEROL Respiratory
Influenza [2] LEVODOPA
See: www.drugeruptiondata.com/drug/id/876 Nasopharyngitis [5]
Endocrine/Metabolic Synonyms: L-dopa; carbidopa
Creatine phosphokinase increased [3] Trade names: Duopa (Abbvie), Rytary (Impax),
LEVAMISOLE Libido decreased [2] Sinemet (Bristol-Myers Squibb), Stalevo (Orion)
Weight gain [4] Indications: Parkinsonism
See: www.drugeruptiondata.com/drug/id/395 Genitourinary Class: Dopamine precursor
Sexual dysfunction [2] Half-life: 13 hours
Renal interactions with: ACE inhibitors, acebutolol,
Nephrotoxicity [2] alfuzosin, alpha blockers, amisulpride, ampicillin,
Hematologic angiotensin II receptor antagonists, anti-
Hemotoxicity [2] hypertensives, antimuscarinics, antipsychotics,
Pancytopenia [2] baclofen, benzodiazepines, beta blockers,
Thrombocytopenia [2] bupropion, calcium channel blockers, captopril,
Litt’s Drug Eruption & Reaction Manual LEVOMEPROMAZINE
chloramphenicol, cholestyramine, cilazapril, Back pain [2] Radiation recall dermatitis [2]
clobazam, clonidine, darifenacin, diazoxide, Gastrointestinal/Hepatic Rash (2%) [2]
diuretics, dopamine D2 receptor antagonists, Abdominal pain [2] Stevens-Johnson syndrome [2]
enalapril, erythromycin, fosinopril, hydralazine, Constipation [4] Toxic epidermal necrolysis [5]
irbesartan, iron salts, isoniazid, levomepromazine, Diarrhea [2] Vasculitis [3]
linezolid, lisinopril, MAO inhibitors, memantine, Hepatotoxicity [2] Cardiovascular
methyldopa, metoclopramide, minoxidil, Nausea [9] Myocardial infarction [2]
moclobemide, moxonidine, nitrates, olanzapine, Vomiting [4] Palpitation [2]
olmesartan, oral iron, oxybutynin, paliperidone, QT prolongation [5]
papaverine, pericyazine, phenelzine, phenytoin, Endocrine/Metabolic
Weight loss [2] Torsades de pointes [6]
probenecid, pyridoxine, quetiapine, quinapril,
ramipril, rifampin, risperidone, sapropterin, Ocular Central Nervous System
selegiline, sodium nitroprusside, sulpiride, Hallucinations, visual [2] Anorexia [2]
tetrabenazine, tiotropium, trandolapril, Ocular adverse effects [2] Delirium [5]
tranylcypromine, tricyclic antidepressants, Depression [2]
Other Dysgeusia (taste perversion) [2]
trospium, volatile liquid general anesthetics, Adverse effects [2]
ziprasidone, zuclopenthixol, zuclopenthixol Headache (6%) [6]
Hiccups [2] Insomnia (4%) [3]
acetate, zuclopenthixol decanoate, zuclopenthixol
dihydrochloride Peripheral neuropathy [3]
Pregnancy category: C Psychosis [2]
Important contra-indications noted in the LEVOFLOXACIN Seizures [9]
prescribing guidelines for: nursing mothers; Vertigo (dizziness) [6]
pediatric patients Trade names: Iquix (Santen), Levaquin (Ortho- Neuromuscular/Skeletal
Note: Levodopa is always used in conjuntion with McNeil), Quixin (Johnson & Johnson), Tavanic Arthralgia [4]
carbidopa. Stalevo is levodopa, carbidopa and (Sanofi-Aventis) Myalgia/Myopathy [4]
entacapone. Contra-indicated in patients with Indications: Various infections caused by Myasthenia gravis (exacerbation) [3]
narrow-angle glaucoma or those with a history of susceptible organisms, inhalational anthrax (post Rhabdomyolysis [4]
melanoma. exposure) Tendinitis [2]
Class: Antibiotic, fluoroquinolone Tendinopathy/Tendon rupture [35]
Half-life: 68 hours
Skin Clinically important, potentially hazardous Gastrointestinal/Hepatic
Chromhidrosis (<10%) interactions with: alfuzosin, aminophylline, Abdominal pain [3]
Edema [2] amiodarone, antacids, antidiabetics, arsenic, Constipation (3%)
Exanthems [2] artemether/lumefantrine, BCG vaccine, Diarrhea (5%) [4]
Lupus erythematosus [2] chloroquine, ciprofloxacin, corticosteroids, Hepatotoxicity [4]
Melanoma [28] cyclosporine, didanosine, dronedarone, Nausea (7%) [6]
Rash [3] gadobutrol, insulin, lanthanum, mycophenolate, Vomiting [3]
Hair nilotinib, NSAIDs, oral iron, oral typhoid vaccine, Endocrine/Metabolic
Hair pigmentation [2] phenindione, pimozide, probenecid, QT ALT increased [3]
Nails prolonging agents, quinine, strontium ranelate, AST increased [3]
Nail growth [2] sucralfate, sulfonylureas, tetrabenazine, Hypoglycemia [3]
thioridazine, vitamin K antagonists, warfarin, zinc, Genitourinary
Mucosal ziprasidone, zolmitriptan
Xerostomia (<10%) [2] Vaginitis (2%)
Cardiovascular Important contra-indications noted in the Renal
Hypotension [2] prescribing guidelines for: the elderly; nursing Nephrotoxicity [5]
Orthostatic hypotension [4] mothers Hematologic
Central Nervous System Note: Fluoroquinolones are associated with an Thrombocytopenia [5]
Agitation [2] increased risk of tendinitis and tendon rupture in Other
Anosmia [2] all ages. This risk is further increased in older
Anxiety [2] patients usually over 60 years of age, in patients
Death [5]
Confusion [3] taking corticosteroid drugs, and in patients with
Side effects [2]
Delusions [2] kidney, heart or lung transplants.
Depression [3] Fluoroquinolones may exacerbate muscle
Dyskinesia [44] weakness in persons with myasthenia gravis.
Gait instability [3] Warning: SERIOUS ADVERSE REACTIONS LEVOLEUCOVORIN
Hallucinations [12] INCLUDING TENDINITIS, TENDON
RUPTURE, PERIPHERAL NEUROPATHY, See: www.drugeruptiondata.com/drug/id/1297
Insomnia [6]
Narcolepsy [2] CENTRIAL NERVOUS SYSTEM EFFECTS and
Neuroleptic malignant syndrome [7] EXACERBATION OF MYASTHENIA GRAVIS
Neurotoxicity [3] LEVOMEPROMAZINE
Psychosis [6] Skin
Restless legs syndrome [5] Anaphylactoid reactions/Anaphylaxis [6] See: www.drugeruptiondata.com/drug/id/2175
Somnolence (drowsiness) [5] Erythema [2]
Suicidal ideation [2] Erythema nodosum (<3%)
Tardive dyskinesia [2] Exanthems [2]
Vertigo (dizziness) [4] Hypersensitivity [5]
Neuromuscular/Skeletal Photosensitivity [3]
Arthralgia [2] Phototoxicity [5]
Asthenia (fatigue) [2] Pruritus (2%) [3]
Purpura [2]
LEVOMILNACIPRAN Over 100 updates per week on www.drugeruptiondata.com

LEVOMILNACIPRAN Adverse effects [2] Restless legs syndrome [2]
Bruxism (<2%) Neuromuscular/Skeletal
Trade name: Fetzima (Forest)
Indications: Major depressive disorder Bone loss [2]
Class: Antidepressant, Serotonin-norepinephrine Fractures [2]
reuptake inhibitor LEVONORGESTREL Endocrine/Metabolic
Half-life: 12 hours Thyrotoxicosis [3]
Clinically important, potentially hazardous Trade names: Kyleena (Bayer), Mirena (Bayer),
Plan B (Duramed) Other
interactions with: ketoconazole, MAO Adverse effects [2]
inhibitors, NSAIDs Indications: Intrauterine contraception,
treatment of heavy menstrual bleeding, Side effects [2]
Important contra-indications noted in the emergency contraception
prescribing guidelines for: nursing mothers; Class: Hormone, Progestogen
pediatric patients Half-life: 17 hours LIDOCAINE
Warning: SUICIDAL THOUGHTS AND Clinically important, potentially hazardous
BEHAVIORS interactions with: barbiturates, bosentan, Synonyms: lignocaine; xylocaine
carbamazepine, CYP3A4 inducers and inhibitors, Trade names: Anamantle HC (Doak), ELA-Max
efavirenz, felbamate, griseofulvin, nevirapine, (Ferndale), EMLA (AstraZeneca), Lidoderm
Skin oxcarbazepine, phenytoin, rifabutin, rifampin, St (Endo), Xylocaine (AstraZeneca)
Hyperhidrosis (9%) [8] John’s wort, topiramate, ulipristal Indications: Ventricular arrhythmias, topical
Pruritus (<2%) Pregnancy category: X anesthesia
Rash (2%) Important contra-indications noted in the Class: Anesthetic, local, Antiarrhythmic,
Urticaria (<2%) prescribing guidelines for: the elderly; nursing Antiarrhythmic class Ib
Xerosis (<2%) mothers; pediatric patients Half-life: terminal: 1.52 hours
Xerostomia [4] Central Nervous System interactions with: amiodarone, amprenavir,
Cardiovascular Headache (17%) [5] antiarrhythmics, atazanavir, cimetidine, cobicistat/
Angina (<2%) Vertigo (dizziness) (11%) elvitegravir/emtricitabine/tenofovir alafenamide,
Extrasystoles (<2%) cobicistat/elvitegravir/emtricitabine/tenofovir
Neuromuscular/Skeletal disoproxil, darunavir, delavirdine, fosamprenavir,
Hypertension (3%) [2] Asthenia (fatigue) (17%)
Hypotension (3%) indinavir, lopinavir, mivacurium, nevirapine,
Palpitation (5%) [4] Gastrointestinal/Hepatic nilutamide, oxprenolol, propranolol, telaprevir
Tachycardia (6%) [8] Abdominal pain (18%) Pregnancy category: B
Diarrhea (5%) Important contra-indications noted in the
Central Nervous System Nausea (23%) [6] prescribing guidelines for: nursing mothers;
Aggression (<2%) Vomiting (6%) [3] pediatric patients
Agitation (<2%)
Extrapyramidal symptoms (<2%) Endocrine/Metabolic
Headache [5] Amenorrhea [3] Skin
Insomnia [3] Mastodynia (11%) [2] Anaphylactoid reactions/Anaphylaxis [7]
Migraine (<2%) Menstrual irregularities (26%) [7] Angioedema [3]
Panic attack (<2%) Genitourinary Dermatitis [27]
Paresthesias (<2%) Vaginal bleeding [3] Eczema [3]
Syncope (<2%) Edema [2]
Other Erythema [3]
Vertigo (dizziness) [4] Adverse effects [2]
Yawning (<2%) Erythema multiforme [2]
Exanthems [2]
Gastrointestinal/Hepatic Exfoliative dermatitis [2]
Abdominal pain (<2%) LEVOTHYROXINE Fixed eruption [2]
Constipation (9%) [8] Hypersensitivity [9]
Flatulence (<2%) Synonyms: L-thyroxine sodium; T4 Pruritus [3]
Nausea (17%) [9] Trade names: Levothyroid (Forest), Levoxyl Toxicity [3]
Vomiting (5%) [4] (Monarch), Synthroid (AbbVie), Unithroid Urticaria [5]
Respiratory (Watson) Cardiovascular
Upper respiratory tract infection [2] Indications: Hypothyroidism Bradycardia [2]
Endocrine/Metabolic Class: Thyroid hormone, synthetic
Half-life: 67 days Central Nervous System
Appetite decreased (3%) Hoigne’s syndrome [2]
Genitourinary interactions with: colesevelam, dicumarol, Seizures [14]
Ejaculatory dysfunction (5%) [3] lanthanum, oral anticoagulants, orlistat, Shivering (<10%)
Erectile dysfunction (6%) [6] propranolol, raloxifene, red rice yeast, ritonavir, Hematologic
Hematuria (<2%) warfarin Methemoglobinemia [4]
Pollakiuria (<2%) Pregnancy category: A
Testicular pain (4%) Otic
Urinary hesitancy (4%) [3] Tinnitus [3]
Skin Local
Renal Angioedema [2]
Proteinuria (<2%) Application-site erythema [2]
Urticaria [3] Application-site reactions [3]
Ocular Cardiovascular Injection-site pain [2]
Conjunctival hemorrhage (<2%) Circulatory collapse [2]
Vision blurred (<2%)
Xerophthalmia (<2%)
Litt’s Drug Eruption & Reaction Manual LINEZOLID
Other Gastroesophageal reflux (<2%) Pregnancy category: C

Adverse effects [3] Vomiting (<2%) Important contra-indications noted in the
Death [3] Respiratory prescribing guidelines for: nursing mothers;
Sinusitis (3%) pediatric patients
LIFITEGRAST Skin
AGEP [3]
Trade name: Xiidra (Shire)
Indications: Ophthalmic solution for dry eye
LINAGLIPTIN Dermatitis [2]
Other
disease Trade names: Glyxambi (Boehringer Ingelheim), Allergic reactions (<5%)
Class: Lymphocyte function-associated antigen-1 Tradjenta (Boehringer Ingelheim)
(LFA-1) antagonist Indications: Type II diabetes mellitus
Half-life: N/A
Class: Antidiabetic, Dipeptidyl peptidase-4 (DPP-
4) inhibitor
LINDANE
interactions with: none known Half-life: 12 hours
Pregnancy category: N/A (No data available) Synonyms: hexachlorocyclohexane; gamma
Clinically important, potentially hazardous benzene hexachloride
Important contra-indications noted in the interactions with: efavirenz, rifampin
prescribing guidelines for: nursing mothers; Indications: Scabies, pediculosis capitis,
Pregnancy category: B pediculosis pubis
pediatric patients Important contra-indications noted in the Class: Chemical, Scabicide
prescribing guidelines for: nursing mothers; Half-life: 1722 hours
Central Nervous System pediatric patients Clinically important, potentially hazardous
Dysgeusia (taste perversion) (5–25%) [3] Note: Linagliptin should not be used in patients interactions with: oil-based hair dressings
Headache (<5%) with Type I diabetes or for the treatment of Pregnancy category: C
Respiratory diabetic ketoacidosis, and has not been studied in Important contra-indications noted in the
Sinusitis (<5%) combination with insulin. Glyxambi is linagliptin prescribing guidelines for: nursing mothers;
and empagliflozin. pediatric patients
Ocular
Conjunctival hyperemia (<5%)
Lacrimation (<5%) Cardiovascular Skin
Ocular adverse effects [2] Cardiotoxicity [3] Dermatitis [5]
Ocular burning [2] Hypertension [2] Erythema (2%) [2]
Ocular discharge (<5%) Central Nervous System Pruritus (2%) [5]
Ocular pruritus (5–25%) [2] Headache [5] Toxicity [2]
Reduced visual acuity (5–25%) [2] Neuromuscular/Skeletal Urticaria [2]
Vision blurred (<5%) Arthralgia [2] Central Nervous System
Xerophthalmia [2] Back pain [3] Neurotoxicity [3]
Local Pain in extremities [2] Pseudotumor cerebri [2]
Application-site reactions [3] Gastrointestinal/Hepatic Seizures [11]
Diarrhea [2] Neuromuscular/Skeletal
Nausea [3] Rhabdomyolysis [3]
LINACLOTIDE Respiratory Other
Cough [4] Adverse effects [4]
Trade name: Linzess (Forest) Nasopharyngitis [7] Death [19]
Indications: Irritable bowel syndrome with Upper respiratory tract infection [5]
constipation and chronic idiopathic constipation
Class: Amino acid, Guanylate cyclase-C agonist Endocrine/Metabolic
Half-life: N/A Hyperglycemia [2] LINEZOLID
Clinically important, potentially hazardous Hyperlipidemia [2]
interactions with: none known Hypertriglyceridemia [2] Trade name: Zyvox (Pfizer)
Pregnancy category: C Hypoglycemia [15] Indications: Various infections caused by
Important contra-indications noted in the Genitourinary susceptible organisms
prescribing guidelines for: nursing mothers; Urinary tract infection [3] Class: Antibiotic, oxazolidinone
pediatric patients Half-life: 45 hours
Note: Contra-indicated in patients with known Adverse effects [17]
or suspected mechanical gastrointestinal interactions with: alcohol, alpha blockers,
Infection [3] altretamine, amitriptyline, amoxapine,
obstruction.
Warning: PEDIATRIC RISK amphetamines, anilidopiperidine opioids,
antihypertensives, atomoxetine, beta blockers,

LINCOMYCIN buprenorphine, bupropion, buspirone, caffeine,
carbamazepine, clomipramine, cyclobenzaprine,
Headache (4%) Trade name: Lincocin (Pfizer) desipramine, desvenlafaxine,
Neuromuscular/Skeletal Indications: Various infections caused by dexmethylphenidate, dextromethorphan,
Asthenia (fatigue) (<2%) susceptible organisms diethylpropion, doxapram, doxepin, fluoxetine,
Gastrointestinal/Hepatic Class: Antibiotic, lincosamide fluvoxamine, hydromorphone, imipramine,
Abdominal distension (2–3%) Half-life: 211.5 hours levodopa, lithium, MAO inhibitors, maprotiline,
Abdominal pain (7%) [3] Clinically important, potentially hazardous meperidine, methadone, methyldopa,
Diarrhea (16–20%) [19] interactions with: mivacurium methylphenidate, mirtazapine, nortriptyline, oral
Dyspepsia (<2%) typhoid vaccine, paroxetine hydrochloride,
Flatulence (4–6%) [3] propoxyphene, protriptyline, reserpine, rifampin,
Gastroenteritis (3%) safinamide, serotonin 5-HT1D receptor agonists,
LINEZOLID See all our books at www.crcpress.com
serotonin/norepinephrine reuptake inhibitors, Allergic reactions (4%) Upper respiratory tract infection (10%) [3]
sertraline, sibutramine, SSRIs, tapentadol, Death [2] Endocrine/Metabolic
tetrabenazine, tetrahydrozoline, tramadol, Appetite decreased [6]
trazodone, tricyclic antidepressants, Hypoglycemia [10]
trimipramine, tryptophan, venlafaxine
LIOTHYRONINE Weight loss [6]
Important contra-indications noted in the Genitourinary
Synonym: T3 sodium Urinary tract infection (6%)
prescribing guidelines for: nursing mothers Trade names: Cytomel (Pfizer), Triostat (Par)
Indications: Hypothyroidism Local
Skin Class: Thyroid hormone, synthetic Injection-site reactions (2%) [3]
Cellulitis [2] Half-life: 1649 hours Other
Edema (2%) Clinically important, potentially hazardous Adverse effects [13]
Fungal dermatitis (2%) interactions with: anticoagulants, dicumarol, Malignant neoplasms (11%)
Pruritus [2] warfarin
Rash (<7%) [3] Pregnancy category: A
Mucosal LISDEXAMFETAMINE
Black tongue [2] Skin
Central Nervous System Urticaria [3] Trade name: Vyvanse (Shire)
Dysgeusia (taste perversion) (<2%) Indications: Attention-deficit hyperactivity
Fever (2–14%) disorder (ADHD)
Headache (<11%) [4] LIRAGLUTIDE Class: CNS stimulant, Dextroamphetamine
prodrug
Insomnia (3%)
Neurotoxicity [5] Trade names: Saxenda (Novo Nordisk), Victoza Half-life: 1 hour
Peripheral neuropathy [12] (Novo Nordisk), Xultophy (Novo Nordisk) Clinically important, potentially hazardous
Seizures (3%) Indications: To improve glycemic control in interactions with: acetazolamide, ammonium
Serotonin syndrome [27] adults with Type II diabetes mellitus (Victoza), chloride, analgesics, antacids, antihistamines,
Vertigo (dizziness) (2%) adjunct to diet and exercise for chronic weight antihypertensives, antipsychotics, atomoxetine,
management (Saxenda) cannabinoids, carbonic anhydrase inhibitors,
Gastrointestinal/Hepatic chlorpromazine, epinephrine, ethosuximide,
Abdominal pain (<2%) Class: Glucagon-like peptide-1 (GLP-1) receptor
agonist haloperidol, iobenguane, lithium, MAO inhibitors,
Constipation (2%) [2] meperidine, methenamine, phenobarbital,
Diarrhea (3–11%) [9] Half-life: 13 hours
Clinically important, potentially hazardous phenytoin, propoxyphene, sympathomimetics,
Gastrointestinal bleeding (2%) tricyclic antidepressants, urinary alkalinizing
Gastrointestinal disorder [2] interactions with: acetaminophen, atorvastatin,
digoxin, griseofulvin, lisinopril, warfarin agents
Loose stools (<2%) Pregnancy category: C
Nausea (3–10%) [9] Pregnancy category: C
Vomiting (<10%) [4] prescribing guidelines for: nursing mothers;
Respiratory pediatric patients pediatric patients
Apnea (2%) Note: Contra-indicated in patients with a Warning: ABUSE AND DEPENDENCE
Cough (<2%) personal or family history of medullary thyroid
Dyspnea (3%) carcinoma or in patients with multiple endocrine Skin
Pneumonia (3%) neoplasia syndrome Type 2. Xultophy is liraglutide Hyperhidrosis (3%)
Upper respiratory tract infection (4%) and insulin degludec. Rash (3%)
Endocrine/Metabolic Warning: RISK OF THYROID C-CELL TUMORS Mucosal
Acidosis [5] Xerostomia (4–26%) [20]
ALP increased (<4%) Cardiovascular
ALT increased (2–10%) Cardiovascular
Cardiotoxicity [2] Hypertension (3%)
AST increased (2–5%) Hypertension (3%)
Hypoglycemia [2] Tachycardia [3]
Hypokalemia (3%) Central Nervous System Central Nervous System
Hyponatremia [2] Headache (~5%) [7] Agitation (3%)
Vertigo (dizziness) (6%) [2] Anorexia (5%) [3]
Genitourinary
Candidal vaginitis (<2%) Neuromuscular/Skeletal Anxiety [8]
Asthenia (fatigue) [3] Fever (2%)
Renal Back pain (5%) [3] Headache [29]
Nephrotoxicity [2] Insomnia (13–23%) [28]
Hematologic Abdominal pain [3] Irritability (10%) [19]
Anemia (<6%) [6] Cholelithiasis (gallstones) [3] Restlessness (3%)
Leukopenia [2] Constipation (10%) [12] Somnolence (drowsiness) (2%) [2]
Myelosuppression [7] Diarrhea (17%) [31] Tic disorder (2%) [2]
Pancytopenia [4] Dyspepsia [3] Vertigo (dizziness) (5%) [6]
Sepsis (8%) Gastrointestinal disorder [3] Neuromuscular/Skeletal
Thrombocytopenia (<5%) [19] Nausea (28%) [61] Asthenia (fatigue) [3]
Ocular Pancreatitis [10] Back pain [2]
Optic neuropathy [14] Vomiting (11%) [30] Muscle spasm [2]
Local Respiratory Gastrointestinal/Hepatic
Injection-site reactions (3%) Influenza (7%) Abdominal pain (12%) [12]
Other Nasopharyngitis (5%) [6] Constipation [2]
Adverse effects (4%) [15] Sinusitis (6%) Diarrhea (7%)
Litt’s Drug Eruption & Reaction Manual LITHIUM
Nausea (6–7%) [10] Skin Pregnancy category: D

Vomiting (9%) [3] Angioedema [43]
Respiratory Edema of lip [2] Skin
Dyspnea (2%) Exanthems (3%) [4] Acneform eruption [20]
Influenza [2] Exfoliative dermatitis [2] Angioedema [2]
Nasopharyngitis [5] Kaposi’s sarcoma [2] Atopic dermatitis (3%)
Sinusitis [2] Lichenoid eruption [2] Darier’s disease [3]
Upper respiratory tract infection [11] Pemphigus foliaceus [2] Dermatitis [4]
Pityriasis rosea [2] Dermatitis herpetiformis [3]
Endocrine/Metabolic Purpura [2]
Appetite decreased (27–39%) [27] Edema [3]
Rash (2%) [5] Erythema [2]
Libido decreased (<2%) Urticaria [2]
Weight loss (9%) [9] Exanthems [11]
Mucosal Exfoliative dermatitis [3]
Genitourinary Tongue edema [2] Follicular keratosis [3]
Erectile dysfunction (<2%) Folliculitis [5]
Cardiovascular
Other Flushing [2] Hidradenitis [3]
Adverse effects [6] Hypotension (<4%) [3] Ichthyosis [2]
Central Nervous System Linear IgA bullous dermatosis [4]
Headache (4–6%) Lupus erythematosus [5]
LISINOPRIL Vertigo (dizziness) (5–12%) Myxedema [10]
Trade names: Prinivil (Merck), Prinzide (Merck), Neuromuscular/Skeletal Papulo-nodular lesions (elbows) [2]
Zestoretic (AstraZeneca), Zestril (AstraZeneca) Asthenia (fatigue) (3%) Pruritus [9]
Psoriasis (2%) [58]
Indications: Hypertension, as adjunctive therapy Gastrointestinal/Hepatic
in the management of heart failure, short-term Purpura [2]
Hepatotoxicity [2]
treatment following myocardial infarction in Pustules [2]
Intestinal angioedema [3]
hemodynamically stable patients Rash (<10%)
Pancreatitis [10]
Class: Angiotensin-converting enzyme (ACE) Seborrheic dermatitis [3]
Respiratory Toxicity [2]
inhibitor
Cough (4–9%) [15] Ulcerations (lower extremities) [5]
Half-life: 12 hours
Upper respiratory tract infection (<2%) Urticaria [3]
interactions with: alcohol, aldesleukin, Endocrine/Metabolic Vasculitis [4]
allopurinol, alpha blockers, alprostadil, amifostine, Hyperkalemia [3] Hair
amiloride, angiotensin II receptor antagonists, Other Alopecia (1019%) [17]
antacids, antidiabetics, antihypertensives, Death [3] Alopecia areata (2%) [3]
antipsychotics, anxiolytics and hypnotics, Nails
aprotinin, azathioprine, baclofen, beta blockers, Nail dystrophy [2]
calcium channel blockers, clonidine,
corticosteroids, cyclosporine, diazoxide,
LITHIUM Mucosal
diuretics, eplerenone, estrogens, everolimus, Lichenoid stomatitis [3]
Trade names: Eskalith (GSK), Lithobid (Solvay) Oral ulceration [4]
general anesthetics, gold & gold compounds,
Indications: Manic-depressive states Sialorrhea [4]
heparins, hydralazine, hypotensives, insulin,
Class: Antipsychotic, Mood stabilizer Stomatitis [2]
levodopa, liraglutide, lithium, MAO inhibitors,
Half-life: 1824 hours Xerostomia [5]
metformin, methyldopa, methylphenidate,
minoxidil, moxisylyte, moxonidine, nitrates,
interactions with: aceclofenac, acemetacin,
Cardiovascular
nitroprusside, NSAIDs, pentoxifylline, Brugada syndrome [5]
acetazolamide, acitretin, amitriptyline, arsenic,
phosphodiesterase 5 inhibitors, potassium salts, QT prolongation [4]
benazepril, bendroflumethiazide, benzthiazide,
prostacyclin analogues, rituximab, salicylates, Central Nervous System
captopril, celecoxib, chlorothiazide,
sirolimus, spironolactone, sulfonylureas, Amnesia [2]
chlorthalidone, cilazapril, citalopram, clozapine,
temsirolimus, tizanidine, tolvaptan, triamterene, Coma [2]
cyclopenthiazide, desvenlafaxine,
trimethoprim, yohimbine Dysgeusia (taste perversion) (>10%)
dichlorphenamide, diclofenac, enalapril,
Pregnancy category: D (category C in first Hallucinations [2]
ethoxzolamide, etoricoxib, fluoxetine,
trimester; category D in second and third Neuroleptic malignant syndrome [7]
flurbiprofen, fosinopril, haloperidol,
trimesters) Neurotoxicity [3]
hydrochlorothiazide, hydroflumethiazide,
Important contra-indications noted in the Parkinsonism [8]
indapamide, insulin degludec, insulin detemir,
prescribing guidelines for: nursing mothers; Pseudohallucinations [2]
insulin glargine, insulin glulisine, irbesartan,
pediatric patients Restless legs syndrome [4]
levomepromazine, linezolid, lisdexamfetamine,
Note: Prinzide and Zestoretic are lisinopril and Serotonin syndrome [5]
lisinopril, lorcaserin, lurasidone, meloxicam,
hydrochlorothiazide. Hydrochlorothiazide is a Somnambulism [3]
meperidine, mesoridazine, methyclothiazide,
sulfonamide and can be absorbed systemically. Tardive dyskinesia [2]
metolazone, metronidazole, milnacipran,
Sulfonamides can produce severe, possibly fatal, Tremor [3]
neostigmine, olanzapine, olmesartan,
paliperidone, paroxetine hydrochloride, Neuromuscular/Skeletal
pericyazine, phenylbutazone, piroxicam, Myasthenia gravis [2]
Contra-indicated in patients with a history of
polythiazide, quinapril, quinethazone, ramipril, Rhabdomyolysis [3]
angioedema related to previous treatment with
rocuronium, rofecoxib, sibutramine, sulpiride,
an ACE inhibitor and in patients with hereditary
tenoxicam, tetrabenazine, thalidomide, thiazides, Endocrine/Metabolic
or idiopathic angioedema. Diabetes insipidus [4]
tinidazole, tolmetin, trandolapril,
Warning: FETAL TOXICITY Hypercalcemia [3]
trichlormethiazide, trifluoperazine, valdecoxib,
venlafaxine, xipamide, ziprasidone, zofenopril, Hyperparathyroidism [5]
zuclopenthixol Hyperthyroidism [2]
LITHIUM Over 100 updates per week on www.drugeruptiondata.com
Hypothyroidism [3]
Thyrotoxicosis [2] LOMITAPIDE LOPERAMIDE
Weight gain [3]
Trade name: Juxtapid (Aegerion) Trade names: Imodium (McNeil), Maalox
Genitourinary Indications: Homozygous familial (Novartis)
Polyuria [2] hypercholesterolemia Indications: Diarrhea
Priapism [5] Class: Lipid regulator Class: Opiate agonist
Renal Half-life: 39.7 hours Half-life: 914 hours
Nephrogenic diabetes insipidus [2] Clinically important, potentially hazardous Clinically important, potentially hazardous
Nephrotoxicity [13] interactions with: bile acid sequestrants, interactions with: St John’s wort
Other boceprevir, clarithromycin, conivaptan, grapefruit Pregnancy category: B
Adverse effects [5] juice, indinavir, itraconazole, ketoconazole, Important contra-indications noted in the
Side effects (2333%) [4] lopinavir, lovastatin, mibefradil, nefazodone, prescribing guidelines for: nursing mothers;
Teratogenicity [3] nelfinavir, oral contraceptives, P-glycoprotein pediatric patients
substrates, posaconazole, ritonavir, saquinavir,
simvastatin, strong or moderate CYP3A4 Cardiovascular
inhibitors, telaprevir, telithromycin, voriconazole,
LIXISENATIDE warfarin
Pregnancy category: X Gastrointestinal/Hepatic
Trade names: Adlyxin (Sanofi-Aventis), Lyxumia Important contra-indications noted in the Abdominal pain [2]
(Sanofi-Aventis), Soliqua (Sanofi-Aventis) prescribing guidelines for: nursing mothers; Constipation [3]
Indications: To improve glycemic control in pediatric patients Nausea [2]
adults with Type II diabetes mellitus Warning: RISK OF HEPATOTOXICITY
Class: Glucagon-like peptide-1 (GLP-1) receptor
agonist
Half-life: 3 hours Mucosal LOPINAVIR
Clinically important, potentially hazardous Nasal congestion (10%)
Trade name: Kaletra (AbbVie)
interactions with: none known Cardiovascular Indications: HIV-1 infected children above the
Pregnancy category: N/A (Use during Angina (10%) age of 2 years and adults, in combination with
pregnancy only if the potential benefit justifies the Chest pain (24%) other antiretroviral agents
potential risk to the fetus) Palpitation (10%) Class: Antiretroviral, HIV-1 protease inhibitor
Important contra-indications noted in the Central Nervous System Half-life: 5–6 hours
prescribing guidelines for: nursing mothers; Fever (10%) Clinically important, potentially hazardous
pediatric patients Headache (10%) interactions with: abacavir, alfuzosin,
Note: Soliqua is lixisenatide and insulin glargine. Vertigo (dizziness) (10%) amiodarone, amprenavir, aripiprazole,
Neuromuscular/Skeletal artemether/lumefantrine, atazanavir, atorvastatin,
Central Nervous System Asthenia (fatigue) (17%) atovaquone, bepridil, bosentan, brigatinib,
Headache (9%) [2] Back pain (14%) bupropion, cabozantinib, carbamazepine,
Vertigo (dizziness) (7%) [2] chlorpheniramine, cisapride, clarithromycin,
Gastrointestinal/Hepatic colchicine, copanlisib, cyclosporine, darifenacin,
Gastrointestinal/Hepatic Abdominal pain (21–34%)
Abdominal distension (2%) darunavir, dasatinib, delavirdine, dexamethasone,
Constipation (21%) didanosine, digoxin, disulfiram, efavirenz, elbasvir
Abdominal pain (2%) Defecation (urgency) (10%)
Constipation (3%) & grazoprevir, eltrombopag, eluxadoline,
Diarrhea (79%) [3] ergotamine, estradiol, felodipine, fentanyl,
Diarrhea (8%) [9] Dyspepsia (38%) [3]
Dyspepsia (3%) flecainide, fluticasone propionate, fosamprenavir,
Flatulence (21%) glecaprevir & pibrentasvir, indinavir, itraconazole,
Nausea (25%) [21] Gastroenteritis (14%)
Vomiting (10%) [20] ketoconazole, lidocaine, lidocaine, lomitapide,
Gastroesophageal reflux (10%) lovastatin, maraviroc, methadone,
Endocrine/Metabolic Hepatotoxicity [5] methylergonovine, metronidazole, midazolam,
Hypoglycemia (3%) [7] Nausea (65%) [2] midostaurin, mifepristone, nelfinavir, neratinib,
Local Tenesmus (10%) nevirapine, nicardipine, nifedipine, nilotinib,
Injection-site reactions (4%) [2] Vomiting (34%) [3] olaparib, ombitasvir/paritaprevir/ritonavir,
Other Respiratory palbociclib, phenobarbital, phenytoin, pimozide,
Adverse effects [3] Influenza (21%) pitavastatin, ponatinib, primidone, quinidine,
Allergic reactions [2] Nasopharyngitis (17%) ranolazine, ribociclib, rifabutin, rifampin,
Pharyngolaryngeal pain (14%) rilpivirine, rivaroxaban, rosuvastatin, ruxolitinib,
Endocrine/Metabolic salmeterol, saquinavir, sildenafil, simeprevir,
simvastatin, sirolimus, sofosbuvir/velpatasvir/
LODOXAMIDE ALT increased (17%) [3]
Weight loss (24%) voxilaprevir, St John’s wort, tacrolimus, tadalafil,
telithromycin, tenofovir disoproxil, tipranavir,
See: www.drugeruptiondata.com/drug/id/1207 Other tolterodine, trazodone, triazolam, vardenafil,
Adverse effects [5] venetoclax, vinblastine, vincristine, voriconazole,
warfarin, zidovudine
LOMEFLOXACIN Pregnancy category: C
LOMUSTINE Important contra-indications noted in the
See: www.drugeruptiondata.com/drug/id/407 prescribing guidelines for: nursing mothers
See: www.drugeruptiondata.com/drug/id/408 Note: Kaletra is lopinavir and ritonavir.
Skin
Acneform eruption (<10%)
Lipodystrophy (<10%)
Litt’s Drug Eruption & Reaction Manual LORCASERIN
Rash (<10%) [5] Myalgia/Myopathy (>2%)

Hair Respiratory
LORCASERIN
Alopecia [3] Pharyngitis [2] Trade name: Belviq (Arena)
Central Nervous System Endocrine/Metabolic Indications: Obesity in adults who have at least
Vertigo (dizziness) [2] Gynecomastia (>2%) one weight-related health condition, such as high
Neuromuscular/Skeletal Mastodynia (<10%) blood pressure, Type II diabetes, or high
Asthenia (fatigue) (<10%) [2] Genitourinary cholesterol
Vaginitis (>2%) Class: Serotonin receptor agonist
Gastrointestinal/Hepatic Half-life: ~11 hours
Diarrhea (>10%) [5] Clinically important, potentially hazardous
Flatulence (<10%) interactions with: antipsychotics, bupropion,
Nausea (<10%) [4] LORAZEPAM dextromethorphan, lithium, MAO inhibitors,
Pancreatitis [2] SNRIs, SSRIs, St John’s wort, tramadol, tricyclic
Vomiting (<10%) [3] Trade name: Ativan (Valeant) antidepressants, triptans
Renal Indications: Anxiety, depression Pregnancy category: X
Nephrolithiasis [2] Class: Benzodiazepine Important contra-indications noted in the
Half-life: 1020 hours prescribing guidelines for: nursing mothers;
interactions with: alcohol, amprenavir,
LORACARBEF barbiturates, chlorpheniramine, clarithromycin,
clozapine, CNS depressants, cobicistat/ Skin
See: www.drugeruptiondata.com/drug/id/410 elvitegravir/emtricitabine/tenofovir alafenamide, Peripheral edema (5%)
efavirenz, erythromycin, esomeprazole, Rash (2%)
eszopiclone, imatinib, MAO inhibitors, narcotics, Mucosal
LORATADINE nelfinavir, phenothiazines, valproate Nasal congestion (3%)
Pregnancy category: D Oropharyngeal pain (4%)
Trade names: Alavert (Wyeth), Claritin Xerostomia (5%) [2]
(Schering), Claritin-D (Schering) Skin Cardiovascular
Indications: Allergic rhinitis, urticaria Dermatitis (<10%) Hypertension (5%)
Class: Histamine H1 receptor antagonist Diaphoresis (>10%) Valvulopathy (2–3%) [5]
Half-life: 320 hours Pseudolymphoma [2]
Clinically important, potentially hazardous Central Nervous System
Rash (>10%) Anxiety (4%)
interactions with: amiodarone
Pregnancy category: B Mucosal Cognitive impairment (2%) [2]
Nasal congestion (<10%) Depression (2%) [2]
Sialopenia (>10%) Euphoria [2]
Skin Xerostomia (>10%) Headache (15–17%) [11]
Anaphylactoid reactions/Anaphylaxis (>2%) Insomnia (4%)
Angioedema (>2%) Cardiovascular
Hypotension [2] Vertigo (dizziness) (7–9%) [9]
Dermatitis (>2%)
Diaphoresis (>2%) Central Nervous System Neuromuscular/Skeletal
Erythema multiforme (>2%) Agitation [2] Asthenia (fatigue) (7%) [3]
Fixed eruption [3] Akathisia (<10%) Back pain (6–12%) [2]
Peripheral edema (>2%) Amnesia (<10%) [18] Bone or joint pain (2%)
Photosensitivity (>2%) Catatonia [2] Muscle spasm (5%)
Pruritus (>2%) Confusion (<10%) Gastrointestinal/Hepatic
Purpura (>2%) Delirium [2] Constipation (6%)
Rash (>2%) Depression (<10%) Diarrhea (7%)
Urticaria (>2%) [4] Hallucinations [2] Gastroenteritis (3%)
Xerosis (>2%) Headache (<10%) Nausea (8–9%) [9]
Hair Somnolence (drowsiness) (<10%) [3] Vomiting (4%)
Alopecia (>2%) Tremor (<10%) Respiratory
Dry hair (>2%) Vertigo (dizziness) (<10%) [2] Cough (4%)
Mucosal Respiratory Nasopharyngitis (11–13%) [2]
Sialorrhea (>2%) Apnea (<10%) Upper respiratory tract infection (14%)
Stomatitis (>2%) Hyperventilation (<10%) Endocrine/Metabolic
Xerostomia (>10%) [9] Ocular Appetite decreased (2%)
Cardiovascular Visual disturbances (<10%) Diabetes mellitus (exacerbation) (3%)
Flushing (>2%) Local Hypoglycemia (29%) [3]
QT prolongation [2] Injection-site pain (>10%) Genitourinary
Torsades de pointes [4] Injection-site phlebitis (>10%) Urinary tract infection (7–9%)
Central Nervous System Other Other
Dysgeusia (taste perversion) (>2%) Adverse effects [2] Toothache (3%)
Headache (12%) [3]
Hyperesthesia (>2%)
Paresthesias (>2%) LORCAINIDE
Neuromuscular/Skeletal See: www.drugeruptiondata.com/drug/id/1304
LOSARTAN See all our books at www.crcpress.com
tacrolimus, telaprevir, telithromycin, ticagrelor,

LOSARTAN tipranavir, tolvaptan, verapamil LUBIPROSTONE
Pregnancy category: X
Trade names: Cozaar (Merck), Hyzaar (Merck) Important contra-indications noted in the Trade name: Amitiza (Takeda)
Indications: Hypertension prescribing guidelines for: nursing mothers Indications: Constipation, irritable bowel
Class: Angiotensin II receptor antagonist syndrome
(blocker), Antihypertensive Class: Chloride channel activator
Half-life: 2 hours Skin Half-life: 01.4 hours
Clinically important, potentially hazardous Exanthems (<5%) [3] Clinically important, potentially hazardous
interactions with: aliskiren, rifampin, Lupus erythematosus [4] interactions with: none known
voriconazole Pruritus (5%) [2] Pregnancy category: C
Pregnancy category: D (category C in first Rash (5%) [3] Important contra-indications noted in the
trimester; category D in second and third Central Nervous System prescribing guidelines for: nursing mothers;
trimesters) Parkinsonism [2] pediatric patients
Important contra-indications noted in the Neuromuscular/Skeletal Note: Contra-indicated in patients with known
prescribing guidelines for: nursing mothers Asthenia (fatigue) [2] or suspected mechanical gastrointestinal
Note: Hyzaar is losartan and Myalgia/Myopathy (<10%) [6] obstruction.
hydrochlorothiazide. Hydrochlorothiazide is a Rhabdomyolysis [41]
sulfonamide and can be absorbed systemically. Skin
Sulfonamides can produce severe, possibly fatal, Gastrointestinal/Hepatic
Hepatotoxicity [2] Peripheral edema (4%)
Stevens-Johnson syndrome. Pancreatitis [2] Central Nervous System
Warning: USE IN PREGNANCY Endocrine/Metabolic Headache (13%) [7]
Gynecomastia (<10%) Neuromuscular/Skeletal
Skin Arthralgia (3%)
Anaphylactoid reactions/Anaphylaxis [2] Asthenia (fatigue) (2%)
Angioedema [11] LOXAPINE Back pain (2%)
Purpura [2] Gastrointestinal/Hepatic
Mucosal Trade names: Adasuve (Teva), Loxitane Abdominal distension [5]
Nasal congestion (2%) (Watson) Abdominal pain (7%) [8]
Indications: Psychoses Diarrhea [18]
Central Nervous System Class: Antipsychotic, tricyclic Flatulence [3]
Ageusia (taste loss) [2] Half-life: 1219 hours (terminal) Nausea [19]
Vertigo (dizziness) (3%) Clinically important, potentially hazardous Vomiting [7]
Neuromuscular/Skeletal interactions with: none known Respiratory
Back pain (2%) Pregnancy category: C Dyspnea [3]
Respiratory Important contra-indications noted in the Flu-like syndrome (2%)
Upper respiratory tract infection (8%) prescribing guidelines for: the elderly; nursing Sinusitis (5%)
mothers; pediatric patients Upper respiratory tract infection (4%)
Endocrine/Metabolic Warning: BRONCHOSPASM and INCREASED
Hyperkalemia [7] MORTALITY IN ELDERLY PATIENTS WITH Other
Other DEMENTIA-RELATED PSYCHOSIS Adverse effects [3]
Adverse effects [7]
Skin
Rash (<10%) LUCINACTANT
LOTEPREDNOL Mucosal See: www.drugeruptiondata.com/drug/id/2847
Xerostomia (>10%)
Dysgeusia (taste perversion) (14%) [8] LULICONAZOLE
LOVASTATIN Sedation (12%) [4] Trade name: Luzu (Medicis)
Somnolence (drowsiness) [3] Indications: Interdigital tinea pedis, tinea cruris,
Trade names: Advicor (Kos), Altoprev Vertigo (dizziness) [2]
(Shionogi), Mevacor (Merck) and tinea corporis caused by the organisms
Indications: Hypercholesterolemia Neuromuscular/Skeletal Trichophyton rubrum and Epidermophyton floccosum
Class: HMG-CoA reductase inhibitor, Statin Rhabdomyolysis [3] Class: Antifungal, azole
Half-life: 12 hours Gastrointestinal/Hepatic Half-life: N/A
Clinically important, potentially hazardous Dysphagia [2] Clinically important, potentially hazardous
interactions with: amprenavir, atazanavir, interactions with: none known
Respiratory Pregnancy category: C
azithromycin, boceprevir, bosentan, Bronchospasm [3]
cholestyramine, clarithromycin, cyclosporine, Important contra-indications noted in the
Pulmonary toxicity [3] prescribing guidelines for: nursing mothers;
darunavir, dasabuvir/ombitasvir/paritaprevir/
ritonavir, delavirdine, efavirenz, elbasvir & Endocrine/Metabolic pediatric patients
grazoprevir, erythromycin, exenatide, fenofibrate, Gynecomastia (<10%)
fosamprenavir, gemfibrozil, glecaprevir & Skin
pibrentasvir, grapefruit juice, imatinib, indinavir, Contact dermatitis [2]
itraconazole, lomitapide, lopinavir, mifepristone,
nelfinavir, ombitasvir/paritaprevir/ritonavir,
paclitaxel, posaconazole, red rice yeast,
Litt’s Drug Eruption & Reaction Manual LYMECYCLINE
Other Mucosal
LUMACAFTOR/ Adverse effects [2] Sialorrhea (2%)
IVACAFTOR Central Nervous System
Agitation (5%)
Trade name: Orkambi (Vertex) LUMIRACOXIB Akathisia (13%) [19]
Indications: Cystic fibrosis in patients aged 12 Anxiety (5%)
years and older who are homozygous for the See: www.drugeruptiondata.com/drug/id/1245 Extrapyramidal symptoms [2]
F508del mutation in the CFTR gene Insomnia (10%) [2]
Class: CFTR potentiator, CYP3A4 inducer Parkinsonism (10%) [5]
Half-life: 26 hours
LURASIDONE Restlessness (2%) [2]
Sedation [8]
interactions with: rifampin, St John’s wort Trade name: Latuda (Sunovion) Somnolence (drowsiness) (17%) [13]
Pregnancy category: B Indications: Schizophrenia, depressive epidodes Vertigo (dizziness) (4%) [3]
Important contra-indications noted in the associated with bipolar I disorder Neuromuscular/Skeletal
prescribing guidelines for: nursing mothers; Class: Antipsychotic Dystonia (5%)
pediatric patients Half-life: 18 hours
Note: See also separate profile for ivacaftor. Gastrointestinal/Hepatic
Clinically important, potentially hazardous Dyspepsia (6%)
interactions with: alcohol, amphetamines, CNS Nausea (10%) [11]
Skin depressants, dasabuvir/ombitasvir/paritaprevir/ Vomiting (8%) [3]
Rash (7%) [2] ritonavir, dasatinib, deferasirox, diltiazem,
disopyramide, dopamine, dopamine agonists, Endocrine/Metabolic
Mucosal Hyperprolactinemia [2]
droperidol, efavirenz, epinephrine, hydroxyzine,
Rhinorrhea (6%) Weight gain (5%) [3]
ketoconazole, levomepromazine, lithium, MAO
Neuromuscular/Skeletal inhibitors, methylphenidate, metoclopramide, Other
Asthenia (fatigue) (9%) ombitasvir/paritaprevir/ritonavir, pimozide, Adverse effects [3]
Gastrointestinal/Hepatic procainamide, quinagolide, quinidine, rifampin,
Diarrhea (12%) strong CYP3A4 inducers or inhibitors,
tetrabenazine, tocilizumab
Flatulence (7%)
Nausea (13%) Pregnancy category: B
LUTROPIN ALFA
Respiratory See: www.drugeruptiondata.com/drug/id/1148
Dyspnea (13%) [3]
Influenza (5%)
Warning: INCREASED MORTALITY IN
ELDERLY PATIENTS WITH DEMENTIA- LYMECYCLINE
RELATED PSYCHOSIS
Endocrine/Metabolic See: www.drugeruptiondata.com/drug/id/1359
Creatine phosphokinase increased (7%)
Menstrual irregularities (10%)
MACITENTAN Over 100 updates per week on www.drugeruptiondata.com
Folliculitis (5%) Ocular

MACITENTAN Lipodystrophy (5%) Hallucinations, visual [2]
Pruritus (6%) [2] Other
Trade name: Opsumit (Actelion) Rash (17%) [2]
Indications: Pulmonary arterial hypertension Adverse effects [2]
Class: Endothelin receptor (ETR) antagonist Mucosal
Half-life: 16 hours Stomatitis (4%)
Clinically important, potentially hazardous Cardiovascular MAZINDOL
interactions with: ketoconazole, rifampin, Postural hypotension [2]
ritonavir, strong CYP3A4 inducers or inhibitors Central Nervous System See: www.drugeruptiondata.com/drug/id/418
Pregnancy category: X Depression (6%)
Important contra-indications noted in the Fever (21%) [2]
pediatric patients
Headache [3] MDMA
Pain (8%)
Note: Contra-indicated in pregnancy. Paresthesias (8%) Synonyms: 3,4-
Warning: EMBRYO-FETAL TOXICITY Peripheral neuropathy (5%) methylenedioxymethamphetamine; ecstasy; E; X;
Sleep disturbances (12%) molly; club drug
Skin Vertigo (dizziness) (14%) Indications: N/A
Peripheral edema [3] Neuromuscular/Skeletal Class: Amphetamine
Central Nervous System Asthenia (fatigue) [2] Half-life: N/A
Headache (14%) [6] Myalgia/Myopathy (5%) Clinically important, potentially hazardous
Gastrointestinal/Hepatic Gastrointestinal/Hepatic
Hepatotoxicity [5] Abdominal pain (14%)
Diarrhea [2] Skin
Respiratory Diaphoresis [4]
Bronchitis (12%) [2] Hepatotoxicity [2]
Influenza (6%) Respiratory Mucosal
Nasopharyngitis (20%) [6] Cough (22%) [2] Xerostomia [5]
Pharyngitis (20%) Flu-like syndrome (3%) Cardiovascular
Upper respiratory tract infection [2] Nasopharyngitis [2] Cardiotoxicity [2]
Genitourinary Pneumonia (4%) Myocardial infarction [2]
Urinary tract infection (9%) Upper respiratory tract infection (37%) [2] Central Nervous System
Hematologic Genitourinary Amnesia [2]
Anemia (13%) [8] Urinary tract infection (4%) Confusion [2]
Other Depression (37%) [14]
Adverse effects [6] Hallucinations [4]
Headache [2]
MAFENIDE Hyperthermia [3]
Memory loss [3]
See: www.drugeruptiondata.com/drug/id/931 MARIHUANA Neuroleptic malignant syndrome [4]
Neurotoxicity [5]
Synonyms: marijuana; grass; hashish; pot; Parkinsonism [4]
MAPROTILINE cannabis
Indications: Nausea and vomiting, substance
Psychosis [4]
Seizures [3]
See: www.drugeruptiondata.com/drug/id/416 abuse drug Serotonin syndrome [6]
Class: Antiemetic, Cannabinoid, Hallucinogen
Half-life: N/A Neuromuscular/Skeletal
Clinically important, potentially hazardous Myalgia/Myopathy [2]
MARAVIROC interactions with: atazanavir Rhabdomyolysis [34]
Pregnancy category: N/A Gastrointestinal/Hepatic
Trade names: Celsentri (ViiV), Selzentry (ViiV) Note: Marihuana is the popular name for the Hepatitis [2]
Indications: HIV infection dried flowering leaves of the hemp plant, cannabis Hepatotoxicity [4]
Class: Antiretroviral, CCR5 co-receptor sativa. It contains tetrahydrocannabinols. Nausea [2]
antagonist
Clinically important, potentially hazardous Cardiovascular Hyponatremia [5]
interactions with: atazanavir, clarithromycin, Cardiotoxicity [4] SIADH [8]
conivaptan, CYP3A4 inhibitors or inducers, Myocardial infarction [2] Genitourinary
darunavir, dasatinib, deferasirox, delavirdine, Central Nervous System Priapism [2]
efavirenz, etravirine, indinavir, ketoconazole, Amnesia [2] Hematologic
lopinavir, nelfinavir, oxcarbazepine, rifampin, Hallucinations [2] Coagulopathy [2]
rifapentine, ritonavir, saquinavir, St John’s wort, Neurotoxicity [2]
telithromycin, voriconazole Schizophrenia [3] Ocular
Pregnancy category: B Seizures [2] Hallucinations, visual [2]
Important contra-indications noted in the Stroke [2] Other
prescribing guidelines for: the elderly; nursing Gastrointestinal/Hepatic Bruxism [8]
mothers; pediatric patients Pancreatitis [2] Death [47]
Warning: HEPATOTOXICITY Dipsia (thirst) [2]
Genitourinary Multiorgan failure [2]
Priapism [2]
Skin
Dermatitis (5%)
Litt’s Drug Eruption & Reaction Manual MEFENAMIC ACID
MEASLES, MUMPS & Abdominal pain [4] MEDROXY-
RUBELLA (MMR) VIRUS PROGESTERONE
VACCINE MEBEVERINE Trade names: Depo-Provera (Pfizer), Lunelle
(Pfizer), Premphase (Wyeth), Prempro (Wyeth),
Trade name: M-M-R II (Merck) See: www.drugeruptiondata.com/drug/id/1418 Provera (Pfizer)
Indications: Protection against measles Indications: Secondary amenorrhea, renal or
(rubeola), mumps and rubella (German measles) endometrial carcinoma
Class: Vaccine
Half-life: N/A
MECAMYLAMINE Class: Progestogen
Half-life: 30 days
Clinically important, potentially hazardous See: www.drugeruptiondata.com/drug/id/965 Clinically important, potentially hazardous
interactions with: none known interactions with: acitretin, dofetilide
Pregnancy category: C Pregnancy category: X
prescribing guidelines for: nursing mothers; MECASERMIN Skin
pediatric patients
Note: Contra-indicated for pregnant females; See: www.drugeruptiondata.com/drug/id/1089 Acneform eruption (<5%)
patients who have had anaphylactic or
Chloasma (<10%)
anaphylactoid reactions to neomycin; febrile
Diaphoresis (<31%)
Edema (>10%)
respiratory illness or other active febrile infection; MECHLORETHAMINE Melasma (<10%)
patients receiving immunosuppressive therapy or
with blood dyscrasias, leukemia, lymphomas of
Pruritus (<10%)
Synonyms: mustine; nitrogen mustard
any type, or other malignant neoplasms affecting
Rash (<5%)
Indications: Hodgkin’s disease, mycosis
the bone marrow or lymphatic systems; primary fungoides Hair
and acquired immunodeficiency states, or Class: Alkylating agent Alopecia (<5%)
individuals with a family history of congenital or Half-life: <1 minute Cardiovascular
hereditary immunodeficiency, until the immune Clinically important, potentially hazardous Flushing (12%)
competence of the potential vaccine recipient is interactions with: aldesleukin, vaccines Thrombophlebitis (<10%)
demonstrated. Pregnancy category: D
Osteoporosis [2]
Skin Skin
Henoch–Schönlein purpura [2] Endocrine/Metabolic
Anaphylactoid reactions/Anaphylaxis
Rash [4] Amenorrhea [3]
(<10%) [4]
Galactorrhea [2]
Central Nervous System Bullous dermatitis [3]
Mastodynia (<5%)
Fever [7] Dermatitis [26]
Weight gain [3]
Seizures [3] Herpes zoster (>10%)
Hypersensitivity (<10%) Genitourinary
Neuromuscular/Skeletal Pigmentation [8] Vaginitis (<5%)
Asthenia (fatigue) [2] Pruritus [2] Local
Gastrointestinal/Hepatic Squamous cell carcinoma [3] Injection-site pain (>10%)
Vomiting [2] Urticaria [3]
Local Hair
Injection-site erythema [2]
Alopecia (<10%) MEFENAMIC ACID
Injection-site reactions [3] Dysgeusia (taste perversion) (<10%) Trade name: Ponstel (First Horizon)
Other Indications: Pain, dysmenorrhea
Local
Adverse effects [5] Class: Non-steroidal anti-inflammatory (NSAID)
Injection-site extravasation (<10%)
Infection [2] Half-life: 3.5 hours
Injection-site thrombophlebitis (<10%) [2]
interactions with: methotrexate
MEBENDAZOLE MECLIZINE Important contra-indications noted in the
Trade name: Vermox (Janssen) See: www.drugeruptiondata.com/drug/id/421 pediatric patients
Indications: Parasitic worm infestations
Note: NSAIDs may cause an increased risk of
Class: Anthelmintic, Antibiotic, imidazole
serious cardiovascular and gastrointestinal
Clinically important, potentially hazardous MECLOFENAMATE adverse events, which can be fatal. This risk may
interactions with: aminophylline
See: www.drugeruptiondata.com/drug/id/422 Warning: CARDIOVASCULAR AND
GASTROINTESTINAL RISK
Skin
Skin
Hair Erythema multiforme [2]
Alopecia [3] Fixed eruption [12]
Central Nervous System Pruritus (<10%)
Headache [2] Rash (>10%)
Vertigo (dizziness) [2] Toxic epidermal necrolysis [2]
MEFENAMIC ACID See all our books at www.crcpress.com
Cardiovascular Gastrointestinal/Hepatic Hypersensitivity [2]

Myocardial infarction [2] Abdominal pain [4] Photosensitivity (<2%)
Central Nervous System Diarrhea [4] Pruritus (<2%) [3]
Seizures [2] Nausea [8] Purpura (<2%)
Vomiting [14] Rash (<3%) [3]
Gastrointestinal/Hepatic Stevens-Johnson syndrome (<2%)
Hepatotoxicity [2] Otic
Tinnitus (<10%) Toxic epidermal necrolysis (<2%)
Renal Urticaria (<2%) [4]
Renal failure [2] Ocular Vasculitis (<2%)
Maculopathy [2]
Ocular Hair
Glaucoma [2] Other Alopecia (<2%)
Adverse effects [2]
Death [3] Mucosal
Ulcerative stomatitis (<2%)
MEFLOQUINE Xerostomia (<2%)
MELOXICAM Cardiovascular
Trade name: Lariam (Roche) Angina (<2%)
Indications: Malaria Arrhythmias (<2%)
Class: Antimalarial, Antiprotozoal Trade name: Mobic (Boehringer Ingelheim)
Indications: Osteoarthritis Cardiac failure (<2%)
Half-life: 2122 days Hypertension (<2%)
Clinically important, potentially hazardous Class: COX-2 inhibitor, Non-steroidal anti-
inflammatory (NSAID) Hypotension (<2%)
interactions with: acebutolol, artemether/ Myocardial infarction (<2%)
lumefantrine, ethosuximide, halofantrine, Half-life: 1520 hours
Clinically important, potentially hazardous Palpitation (<2%)
ketoconazole, lacosamide, moxifloxacin, Tachycardia (<2%)
oxcarbazepine, quinine, tiagabine, typhoid interactions with: ACE inhibitors, adrenergic
vaccine, vigabatrin neurone blockers, alcohol, aliskiren, alpha Central Nervous System
Pregnancy category: C blockers, angiotensin II receptor antagonists, Abnormal dreams (<2%)
Important contra-indications noted in the anticoagulants, antidepressants, antiplatelet Anxiety (<2%)
prescribing guidelines for: nursing mothers agents, aspirin, baclofen, beta blockers, bile acid Confusion (<2%)
Warning: NEUROPSYCHIATRIC ADVERSE sequestrants, calcium channel blockers, cardiac Depression (<2%)
REACTIONS glycosides, cholestyramine, clonidine, clopidogrel, Dysgeusia (taste perversion) (<2%)
collagenase, conivaptan, corticosteroids, Fever (<2%)
coumarins, cyclosporine, dabigatran, dasatinib, Headache (2–6%) [2]
Skin desmopressin, diazoxide, digoxin, diuretics, Insomnia (<4%)
Anaphylactoid reactions/Anaphylaxis [2] drotrecogin alfa, eplerenone, erlotinib, Nervousness (<2%)
Erythema [2] glucosamine, haloperidol, heparins, hydralazine, Pain (4%)
Exanthems (30%) ibritumomab, iloprost, ketorolac, lithium, Paresthesias (<2%)
Pruritus (410%) [2] methotrexate, methyldopa, mifamurtide, Seizures (<2%)
Psoriasis [2] minoxidil, moxonidine, nitrates, nitroprusside, Somnolence (drowsiness) (<2%)
Rash (<10%) NSAIDs, pemetrexed, penicillamine, pentosan, Syncope (<2%)
Stevens-Johnson syndrome [2] pentoxifylline, phenindione, pralatrexate, Tremor (<2%)
Toxic epidermal necrolysis [2] prasugrel, probenecid, prostacyclin analogues, Vertigo (dizziness) (<3%)
Vasculitis [3] quinolones, ritonavir, serotonin/norepinephrine Neuromuscular/Skeletal
Cardiovascular reuptake inhibitors, SSRIs, sulfonylureas, Arthralgia (<5%)
Palpitation [3] tacrolimus, thrombolytic agents, tositumomab & Asthenia (fatigue) [2]
Tachycardia [2] iodine131, treprostinil, vancomycin, venlafaxine, Back pain (<3%)
Central Nervous System vitamin K antagonists, voriconazole, zidovudine Bone or joint pain (2%)
Abnormal dreams [3] Pregnancy category: C (category D from 30
weeks gestation) Gastrointestinal/Hepatic
Aggression [2] Abdominal pain (2–5%) [2]
Amnesia [2] Important contra-indications noted in the
prescribing guidelines for: the elderly; nursing Black stools (<2%)
Anorexia [2] Colitis (<2%)
Anxiety [5] mothers
Note: NSAIDs may cause an increased risk of Constipation (<3%) [2]
Chills (<10%) Diarrhea (2–6%) [2]
Confusion [2] serious cardiovascular and gastrointestinal
adverse events, which can be fatal. This risk may Dyspepsia (4–10%) [2]
Delusions [2] Eructation (belching) (<2%)
Depression [7] increase with duration of use.
Warning: CARDIOVASCULAR AND Esophagitis (<2%)
Fever (<10%) [2] Flatulence (<3%)
Hallucinations [3] GASTROINTESTINAL RISKS
Gastritis (<2%)
Headache (<10%) [5] Gastroesophageal reflux (<2%)
Insomnia [3] Skin Gastrointestinal bleeding [2]
Mania [4] Anaphylactoid reactions/Anaphylaxis (<2%) Gastrointestinal perforation (<2%) [2]
Neurotoxicity [8] Angioedema (<2%) [3] Gastrointestinal ulceration (<2%) [3]
Psychosis [8] Bullous dermatitis (<2%) Hematemesis (<2%)
Seizures [6] Edema (25%) Hepatitis (<2%)
Sleep disturbances [2] Erythema [2] Hepatotoxicity [6]
Suicidal ideation [2] Erythema multiforme (<2%) Nausea (3–7%) [4]
Vertigo (dizziness) (<10%) [20] Exanthems (<2%) Pancreatitis (<2%)
Neuromuscular/Skeletal Facial edema (<2%) Vomiting (<3%)
Arthralgia [2] Hematoma [3]
Hot flashes (<2%) Respiratory
Asthenia (fatigue) (<10%) [2] Asthma (<2%)
Myalgia/Myopathy (<10%) [2] Hyperhidrosis (<2%)
Litt’s Drug Eruption & Reaction Manual MENINGOCOCCAL GROUP B VACCINE
Bronchospasm (<2%) Nails Genitourinary

Cough (<2%) Beau’s lines (transverse nail bands) [4] Urinary tract infection [2]
Dyspnea (<2%) Mucosal Ocular
Flu-like syndrome (2–3%) Mucositis [8] Hallucinations, visual [2]
Upper respiratory tract infection (<8%) Oral mucositis [4] Other
Endocrine/Metabolic Stomatitis (<10%) [2] Adverse effects [3]
ALT increased (<2%) Cardiovascular
Appetite increased (<2%) Atrial fibrillation [2]
AST increased (<2%)
Dehydration (<2%) Central Nervous System MENADIONE
GGT increased (<2%) Peripheral neuropathy [3]
Weight gain (<2%) Neuromuscular/Skeletal See: www.drugeruptiondata.com/drug/id/1961
Weight loss (<2%) Rhabdomyolysis [2]
Genitourinary Gastrointestinal/Hepatic
Albuminuria (<2%) Diarrhea [3] MENINGOCOCCAL
Hematuria (<2%) Hepatotoxicity [2]
Urinary frequency (<2%) Nausea [2]
GROUP B VACCINE
Urinary tract infection (<7%)
Hematologic Trade names: Bexsero (Novartis), Trumenba
Renal Febrile neutropenia [2] (Wyeth)
Nephrotoxicity [2] Neutropenia [5] Indications: Immunization to prevent invasive
Renal failure (<2%) Thrombocytopenia [5] disease caused by Neisseria meningitidis
Hematologic Other serogroup B
Anemia (<4%) Death [2] Class: Vaccine
Leukopenia (<2%) Half-life: N/A
Otic
Tinnitus (<2%) MEMANTINE Pregnancy category: B
Ocular Important contra-indications noted in the
Abnormal vision (<2%) Trade names: Ebixa (Lundbeck), Namenda prescribing guidelines for: the elderly; nursing
Conjunctivitis (<2%) (Forest) mothers; pediatric patients
Indications: Alzheimer’s disease, vascular
Other dementia
Adverse effects (18%) [6] Class: Adamantane, NMDA receptor antagonist Central Nervous System
Allergic reactions (<2%) Half-life: 6080 hours Chills (18–30%)
Clinically important, potentially hazardous Fever (2–8%) [3]
interactions with: amantadine, bromocriptine, Headache (41–57%)
MELPHALAN darifenacin, dextromethorphan, ketamine, Neuromuscular/Skeletal
levodopa, levomepromazine, oxybutynin, Arthralgia (16–22%)
Trade names: Alkeran (GSK), Evomela risperidone, rotigotine, tiotropium, trimethoprim, Asthenia (fatigue) (44–65%)
(Spectrum) trospium, zuclopenthixol Myalgia/Myopathy (35–41%)
Indications: Multiple myeloma, carcinomas Pregnancy category: B Gastrointestinal/Hepatic
Class: Alkylating agent Important contra-indications noted in the Diarrhea (9–15%)
Half-life: 90 minutes prescribing guidelines for: nursing mothers; Vomiting (2–8%)
interactions with: aldesleukin, PEG-interferon, Respiratory
tasonermin Upper respiratory tract infection [2]
Skin
Pregnancy category: D Peripheral edema (>2%) Local
Important contra-indications noted in the Injection-site edema (18–22%)
prescribing guidelines for: the elderly; nursing Central Nervous System Injection-site erythema (15–20%)
mothers; pediatric patients Agitation [2] Injection-site pain (85–93%) [2]
Warning: SEVERE BONE MARROW Confusion [3]
SUPPRESSION, HYPERSENSITIVITY, and Depression (>2%)
LEUKEMOGENICITY Gait instability [3]
Headache (6%) [3]
Vertigo (dizziness) (7%) [6]
Skin
Anaphylactoid reactions/Anaphylaxis [2] Neuromuscular/Skeletal
Angioedema [2] Arthralgia (>2%)
Dermatitis [2] Asthenia (fatigue) (2%)
Exanthems (4%) [4] Back pain (3%)
Hypersensitivity (<10%) Myoclonus [2]
Pruritus (<10%) Gastrointestinal/Hepatic
Rash (<10%) Constipation [2]
Toxicity [3] Diarrhea [2]
Urticaria [3] Vomiting [2]
Vasculitis (<10%)
Respiratory
Vesiculation (<10%)
Cough (4%)
Hair Flu-like syndrome (>2%)
Alopecia (<10%) [2] Nasopharyngitis [2]
MENINGOCOCCAL / HIB VACCINE Over 100 updates per week on www.drugeruptiondata.com
Mucosal Influenza (3%)

MENINGOCOCCAL Xerostomia (<10%) Nasopharyngitis (>3%) [3]
Pharyngitis (>3%)
GROUPS C & Y & Central Nervous System
Rhinitis (>3%)
Catatonia [2]
HAEMOPHILUS B Delirium [2] Sinusitis [2]
Seizures [2]
TETANUS TOXOID Serotonin syndrome [7] Genitourinary
Cystitis (>3%)
CONJUGATE VACCINE Local
Urinary tract infection (3%)
Injection-site erythema [2]
Synonym: HibMenCY Injection-site pain (<10%) Otic
Trade name: Menhibrix (GSK) Ear infection (>3%)
Indications: Immunization to prevent invasive Local
disease caused by Neisseria meningitidis
serogroups C and Y and Haemophilus influenzae
MEPHENYTOIN Injection-site reactions (8%) [2]
Other
Type B See: www.drugeruptiondata.com/drug/id/430 Infection (>3%)
Class: Vaccine
Toothache (>3%)
Half-life: N/A
interactions with: immunosuppressants MEPHOBARBITAL
MEPROBAMATE
prescribing guidelines for: pediatric patients See: www.drugeruptiondata.com/drug/id/432
Central Nervous System MEPIVACAINE

Fever (11–26%)
MEPTAZINOL
Irritability (62–71%)
Sedation (49–63%) See: www.drugeruptiondata.com/drug/id/1340
Endocrine/Metabolic
Appetite decreased (30–34%) MEPOLIZUMAB
Local Trade name: Nucala (GSK)
MERCAPTOPURINE
Injection-site edema (15–25%) [2] Indications: Adjunctive treatment for severe Synonyms: 6-mercaptopurine; 6-MP
Injection-site erythema (21–36%) eosinophilic asthma Trade name: Purinethol (Gate)
Injection-site pain (42–46%) [2] Class: Interleukin-5 antagonist, Monoclonal Indications: Leukemias
antibody Class: Antimetabolite, Antineoplastic
Half-life: 16–22 days Half-life: triphasic: 45 minutes; 2.5 hours; 10
MEPENZOLATE Clinically important, potentially hazardous hours
interactions with: none known Clinically important, potentially hazardous
See: www.drugeruptiondata.com/drug/id/1029 Pregnancy category: N/A (Insufficent evidence interactions with: aldesleukin, allopurinol,
to inform drug-associated risk) balsalazide, febuxostat, influenza vaccine,
Important contra-indications noted in the mycophenolate, natalizumab, olsalazine,
MEPERIDINE pediatric patients
trimethoprim, typhoid vaccine, vaccines, yellow
fever vaccine
Synonym: pethidine Pregnancy category: D
Trade name: Demerol (Sanofi-Aventis) Skin
Indications: Pain Eczema (3%) Skin
Class: Opiate agonist Pruritus (3%) Dermatitis (2%)
Half-life: 34 hours Rash (>3%) Hand–foot syndrome [3]
Clinically important, potentially hazardous Mucosal Hypersensitivity [2]
interactions with: acyclovir, alcohol, Nasal congestion (>3%) Neoplasms [2]
amphetamines, barbiturates, CNS depressants, Peripheral edema [2]
darunavir, duloxetine, fluoxetine, furazolidone,
Fever (>3%) Photosensitivity [2]
general anesthetics, glycopyrrolate, Pigmentation (<10%)
Headache (19%) [4]
glycopyrronium, indinavir, isocarboxazid, Rash (<10%) [2]
Vertigo (dizziness) (>3%)
linezolid, lisdexamfetamine, lithium, MAO
Neuromuscular/Skeletal Hair
inhibitors, moclobemide, phenelzine,
Asthenia (fatigue) (5%) [2] Alopecia [2]
phenobarbital, phenothiazines, phenytoin,
rasagiline, ritonavir, safinamide, selegiline, Back pain (5%) Mucosal
sibutramine, SSRIs, tipranavir, tranquilizers, Bone or joint pain (>3%) Mucositis (<10%)
tranylcypromine, tricyclic antidepressants, Muscle spasm (3%) Oral lesions (<5%) [2]
valacyclovir Gastrointestinal/Hepatic Stomatitis (<10%)
Pregnancy category: C Abdominal pain (3%) Central Nervous System
Important contra-indications noted in the Gastroenteritis (>3%) Fever [3]
prescribing guidelines for: the elderly; nursing Nausea (>3%) [2]
Vomiting (>3%) Hepatotoxicity [5]
Respiratory Nausea [2]
Skin Asthma [2] Pancreatitis [9]
Pruritus [3] Bronchitis (>3%) [2]
Dyspnea (>3%)
Litt’s Drug Eruption & Reaction Manual METAXALONE
Hematologic Nausea (2%) Eosinophilia [3]

Leukopenia [2] Endocrine/Metabolic Otic
Myelosuppression [2] ALT increased (2%) Tinnitus (<3%)
Myelotoxicity [3] AST increased (2%) Other
Other Local Adverse effects [11]
Death [2] Infusion-site reactions (4%) Allergic reactions [2]
Injection-site phlebitis (4%) Kounis syndrome [2]
MEROPENEM
Trade name: Meronem (AstraZeneca)
MESALAMINE MESNA
Indications: Aerobic and anaerobic infections, Synonyms: 5-aminosalicylic acid; 5-ASA; See: www.drugeruptiondata.com/drug/id/435
febrile neutropenia fisalamine; mesalazine
Class: Antibiotic, carbapenem, Thienamycin Trade names: Asacol (Procter & Gamble),
Half-life: 46 hours
Canasa (Aptalis), Lialda (Shire), Pentasa (Shire),
Rowasa (Solvay)
MESORIDAZINE
interactions with: oral contraceptives, Indications: Ulcerative colitis
probenecid, valproic acid See: www.drugeruptiondata.com/drug/id/436
Class: Aminosalicylate
Pregnancy category: B Half-life: 0.51.5 hours
Skin interactions with: azathioprine, NSAIDs, METAMIZOLE
AGEP [2] pantoprazole
Hypersensitivity [3] Pregnancy category: B See: www.drugeruptiondata.com/drug/id/1131
Rash (2%) [6] Important contra-indications noted in the
Central Nervous System prescribing guidelines for: the elderly; nursing
Headache (2%) mothers METAXALONE
Seizures [7]
Skin Trade name: Skelaxin (Elan)
Gastrointestinal/Hepatic Indications: Muscle spasm
Diarrhea [4] Diaphoresis (3%)
Exanthems [3] Class: Central muscle relaxant
Hepatotoxicity [3] Half-life: 4–14 hours
Nausea [2] Hypersensitivity [8]
Lupus erythematosus [2] Clinically important, potentially hazardous
Vomiting [2] interactions with: alcohol, barbiturates,
Photosensitivity [3]
Endocrine/Metabolic Psoriasis [2] conivaptan, droperidol, interferon alfa,
ALT increased [3] Rash (3%) [6] levomepromazine, St John’s wort, tricyclic
AST increased [3] antidepressants
Hair Pregnancy category: B
Local Alopecia [6] Important contra-indications noted in the
Cardiovascular prescribing guidelines for: nursing mothers;
Other Cardiotoxicity [2] pediatric patients
Adverse effects [14] Myocarditis [6] Note: Contra-indicated in patients with known
Death [2] Pericarditis [5] tendency to drug-induced, hemolytic, or other
Central Nervous System anemias, or significantly impaired renal or hepatic
Fever (<6%) [6] function.
MEROPENEM & Headache (2–25%) [5]
Pain (14%) Cardiovascular
VABORBACTAM * Vertigo (dizziness) (2–8%) Tachycardia [2]
Trade name: Vabomere (Rempex) Neuromuscular/Skeletal Central Nervous System
Indications: Complicated urinary tract infections Myalgia/Myopathy (3%) Agitation [2]
caused by susceptible bacteria Gastrointestinal/Hepatic Serotonin syndrome [2]
Class: Antibiotic, carbapenem (meropenem), Abdominal pain (<18%) [6] Somnolence (drowsiness) [3]
Beta-lactamase inhibitor (vaborbactam) Colitis (ulcerative / exacerbation) [3] Vertigo (dizziness) [3]
Half-life: 1–2 hours Diarrhea (2–8%) [4] Gastrointestinal/Hepatic
Clinically important, potentially hazardous Eructation (belching) (16%) Nausea [2]
interactions with: probenecid, valproic acid Flatulence (<6%) [2] Vomiting [2]
Pregnancy category: N/A (Potential risk to Nausea (3–13%) [3]
fetus based on animal studies) Pancreatitis [20]
Important contra-indications noted in the Vomiting (<5%) [2]
Respiratory
Note: See also separate entry for meropenem.
Eosinophilic pneumonia [4]
Pharyngitis (11%)
Skin Pneumonia [5]
Hypersensitivity (2%) Pneumonitis [2]
Central Nervous System Pulmonary toxicity [9]
Fever (2%) Renal
Headache (9%) Nephrotoxicity [6]
Gastrointestinal/Hepatic Hematologic
Diarrhea (3%) Anemia [2]
METFORMIN See all our books at www.crcpress.com
Myalgia/Myopathy (<10%) Mucosal

METFORMIN Gastrointestinal/Hepatic Xerostomia (<10%)
Trade names: Avandamet (GSK), Fortamet Abdominal pain (6%) [5] Cardiovascular
(Andrx), Glucophage (Merck Serono), Constipation [3] QT prolongation [36]
Glucovance (Merck Serono), Invokamet (Janssen), Diarrhea (10–35%) [31] Torsades de pointes [27]
Janumet (Merck Sharpe & Dohme), Synjardy Dyspepsia [5] Ventricular arrhythmia [2]
(Boehringer Ingelheim), Xigduo XR Flatulence [2] Central Nervous System
(AstraZeneca) Gastroenteritis [2] Hallucinations [2]
Indications: Diabetes Hepatotoxicity [6] Hyperalgesia [2]
Class: Antidiabetic, Biguanide Nausea (7–26%) [25] Neurotoxicity [2]
Half-life: 6 hours Pancreatitis [5] Serotonin syndrome [2]
Clinically important, potentially hazardous Vomiting (7–26%) [12] Somnolence (drowsiness) [2]
interactions with: ACE inhibitors, Respiratory Syncope [2]
acetazolamide, alcohol, amiloride, anabolic Bronchitis [3] Neuromuscular/Skeletal
steroids, beta blockers, calcium channel blockers, Dyspnea (<10%) Rhabdomyolysis [4]
captopril, cephalexin, cilazapril, cimetidine, Influenza [2]
corticosteroids, diazoxide, dichlorphenamide, Nasopharyngitis [6] Respiratory
digoxin, disopyramide, diuretics, enalapril, Respiratory tract infection (<10%) Respiratory depression [3]
estrogens, fosinopril, iodinated contrast agents, Sinusitis [2] Genitourinary
isoniazid, ketotifen, lanreotide, lisinopril, Upper respiratory tract infection [6] Sexual dysfunction [2]
luteinizing hormone releasing hormone analogs, Endocrine/Metabolic Local
MAO inhibitors, morphine, nicotinic acid, Acidosis [22] Injection-site pain (<10%)
octreotide, oral contraceptives, pegvisomant, Appetite decreased [5]
phenothiazines, phenytoin, procainamide, Other
Hypoglycemia [15]
progestogens, quinapril, quinidine, quinine, Adverse effects [2]
Weight gain [2]
ramipril, ranitidine, somatropin, Death [14]
Weight loss [5]
sympathomimetics, testosterone, thiazides,
thyroid products, topiramate, trandolapril, Genitourinary
Genital mycotic infections [8]
triamterene, trimethoprim, trospium,
Pollakiuria [3]
METHAMPHETAMINE
vancomycin, zonisamide
Pregnancy category: B Urinary tract infection [11]
Trade name: Desoxyn (Recordati)
Important contra-indications noted in the Renal Indications: Attention deficit disorder, obesity
prescribing guidelines for: the elderly; nursing Nephrotoxicity [5] Class: Amphetamine
mothers; pediatric patients Hematologic Half-life: 45 hours
Note: Lactic acidosis is a rare, but serious, Anemia [2] Clinically important, potentially hazardous
metabolic complication that can occur due to interactions with: fluoxetine, fluvoxamine,
metformin accumulation. Other MAO inhibitors, paroxetine hydrochloride,
Avandamet is metformin and rosiglitazone; Adverse effects [24] phenelzine, sertraline, tranylcypromine
Glucovance is metformin and glyburide; Death [2] Pregnancy category: C
Invokamet is metformin and canagliflozin; Vitamin B-12 deficiency [5] Important contra-indications noted in the
Janumet is metformin and sitagliptin; Synjardy is prescribing guidelines for: nursing mothers;
metformin and empagliflozin; Xigduo XR is pediatric patients
metformin and dapagliflozin. METHADONE Warning: POTENTIAL FOR ABUSE
Warning: LACTIC ACIDOSIS
Trade names: Dolophine (Roxane), Methadose Skin
Skin (Mallinckrodt) Diaphoresis (<10%)
Angioedema [2] Indications: Pain, narcotic addiction
Class: Opiate agonist Mucosal
Bullous pemphigoid [2]
Half-life: 1525 hours Xerostomia (<10%) [5]
Erythema (transient) [3]
Fixed eruption [2] Clinically important, potentially hazardous Cardiovascular
Lichenoid eruption [2] interactions with: abacavir, amprenavir, Polyarteritis nodosa [2]
Peripheral edema [5] boceprevir, citalopram, darunavir, delavirdine,
Photosensitivity (<10%) diazepam, efavirenz, erythromycin, fluconazole,
Depression [2]
Rash (<10%) [4] fluvoxamine, interferon alfa, ketoconazole,
Hallucinations [4]
Urticaria (<10%) [4] linezolid, lopinavir, nelfinavir, nilotinib, paroxetine
Insomnia [2]
Vasculitis [2] hydrochloride, PEG-interferon, quetiapine,
Neurotoxicity [6]
ribociclib, rifapentine, rilpivirine, safinamide, St
Cardiovascular Paranoia [2]
John’s wort, tipranavir, vandetanib, voriconazole,
Flushing (<10%) Parkinsonism [2]
zidovudine, zuclopenthixol
Hypertension [3] Psychosis [11]
Palpitation (<10%) Important contra-indications noted in the Neuromuscular/Skeletal
Central Nervous System prescribing guidelines for: pediatric patients Rhabdomyolysis (43%) [5]
Chills (<10%) Note: Methadone is not licensed for use in Other
Dysgeusia (taste perversion) (3%) children though it can be employed for the Bruxism [4]
Headache (6%) [10] management of neonatal opiate withdrawal Death [3]
Vertigo (dizziness) (<10%) [6] syndrome. Dental disease [2]
Arthralgia [5] Skin
Asthenia (fatigue) (9%) [2] Diaphoresis (<48%) [4]
Back pain [5] Pruritus [2]
Litt’s Drug Eruption & Reaction Manual METHOTREXATE
Molluscum contagiosum [2]

METHANTHELINE METHOTREXATE Necrosis [6]
Neoplasms [2]
See: www.drugeruptiondata.com/drug/id/441 Synonyms: amethopterin; MTX Nodular eruption [15]
Trade names: Rasuvo (Medac), Rheumatrex Non-Hodgkin’s lymphoma [2]
(Stada) Photosensitivity (5%) [9]
METHAZOLAMIDE Indications: Carcinomas, leukemias, lymphomas,
psoriasis, rheumatoid arthritis
Pigmentation (<10%)
Pruritus (<5%)
See: www.drugeruptiondata.com/drug/id/442 Class: Antimetabolite, Disease-modifying Pseudolymphoma [10]
antirheumatic drug (DMARD), Folic acid Radiation recall dermatitis [7]
antagonist Rash (<3%) [11]
Half-life: 310 hours Squamous cell carcinoma [2]
METHENAMINE Clinically important, potentially hazardous Stevens-Johnson syndrome [4]
interactions with: acemetacin, acitretin, Sunburn (reactivation) [6]
See: www.drugeruptiondata.com/drug/id/443 aldesleukin, aminoglycosides, amiodarone, Toxic epidermal necrolysis [8]
amoxicillin, ampicillin, aspirin, bacampicillin, Toxicity [9]
bismuth, carbenicillin, chloroquine, ciprofloxacin, Ulceration of psoriatic plaques [4]
METHICILLIN cisplatin, cloxacillin, co-trimoxazole, Ulcerations [12]
cyclopenthiazide, dapsone, demeclocycline, Urticaria [4]
See: www.drugeruptiondata.com/drug/id/444 dexamethasone, diclofenac, dicloxacillin, Vasculitis (>10%) [9]
doxycycline, echinacea, etodolac, etoricoxib,
etretinate, fenoprofen, flurbiprofen, folic acid Hair
Alopecia (<6%) [25]
METHIMAZOLE antagonists, gadobenate, haloperidol,
hydrocortisone, ibuprofen, indomethacin, Nails
Synonym: thiamazole infliximab, ketoprofen, ketorolac, leflunomide, Nail pigmentation [2]
Trade name: Tapazole (Paladin) magnesium trisalicylate, meclofenamate, Paronychia [2]
Indications: Hyperthyroidism mefenamic acid, meloxicam, methicillin, Mucosal
Class: Antithyroid, hormone modifier mezlocillin, minocycline, nabumetone, nafcillin, Aphthous stomatitis [2]
Half-life: 413 hours naproxen, natalizumab, NSAIDs, omeprazole, Gingivitis (>10%)
Clinically important, potentially hazardous oxacillin, oxaprozin, oxtriphylline, oxytetracycline, Glossitis (>10%)
interactions with: anticoagulants, dicumarol, pantoprazole, paromomycin, penicillin G, Mucocutaneous reactions [2]
warfarin penicillin V, penicillins, phenylbutazone, Mucositis [10]
Pregnancy category: D piperacillin, piperacillin/tazobactam, piroxicam, Nasal septal perforation [2]
polypeptide antibiotics, prednisolone, prednisone, Oral mucositis [6]
pristinamycin, probenecid, procarbazine, Oral ulceration [11]
Skin rofecoxib, salicylates, salsalate, sapropterin,
Aplasia cutis congenita [4] Stomatitis (310%) [18]
sulfadiazine, sulfamethoxazole, sulfapyridine,
Exanthems (<15%) [5] sulfasalazine, sulfisoxazole, sulindac, taxobactam, Cardiovascular
Hypersensitivity [2] tenoxicam, tetracycline, ticarcillin, tolmetin, Hypertension [2]
Lupus erythematosus (<10%) [10] trimethoprim, vaccines Pericardial effusion [2]
Pruritus (<5%) [4] Pregnancy category: X Pericarditis [3]
Rash (>10%) Important contra-indications noted in the Central Nervous System
Urticaria (>5%) [2] prescribing guidelines for: the elderly; nursing Encephalopathy [5]
Vasculitis [6] mothers; pediatric patients Fever [5]
Central Nervous System Warning: SEVERE TOXIC REACTIONS, Headache [16]
Ageusia (taste loss) (<10%) INCLUDING EMBRYOFETAL TOXICITY AND Leukoencephalopathy [61]
Neuromuscular/Skeletal DEATH Migraine [2]
Arthralgia [4] Neurotoxicity [11]
Skin Vertigo (dizziness) [2]
Hepatotoxicity [11] Abscess (peritoneal) [2] Neuromuscular/Skeletal
Pancreatitis [3] Acral erythema [13] Arthralgia [5]
Anaphylactoid reactions/Anaphylaxis Asthenia (fatigue) [13]
Respiratory (<10%) [9] Back pain [2]
Pulmonary toxicity [2] Bullous acral erythema [2] Bone or joint pain [2]
Hematologic Bullous dermatitis [4] Gastrointestinal/Hepatic
Agranulocytosis [10] Capillaritis [2] Abdominal pain [9]
Neutropenia [2] Carcinoma [2] Colitis [2]
Other Dermatitis [2] Diarrhea [12]
Edema [2] Dyspepsia [3]
Side effects (in high dosages) (28%) [2]
Erosion of psoriatic plaques [8] Gastroenteritis [2]
Teratogenicity [2]
Erythema (>10%) Hepatic steatosis [2]
Erythema multiforme [4] Hepatitis [3]
Erythroderma [2] Hepatotoxicity [54]
METHOCARBAMOL Exanthems (15%) [5] Nausea [28]
Folliculitis [2] Vomiting [12]
See: www.drugeruptiondata.com/drug/id/446 Hand–foot syndrome [3]
Herpes simplex [2] Respiratory
Herpes zoster [7] Cough [3]
METHOHEXITAL Hypersensitivity [4] Nasopharyngitis [6]
Lymphoma [5] Pharyngitis [2]
See: www.drugeruptiondata.com/drug/id/447 Malignant lymphoma [4] Pneumonia [6]
METHOTREXATE Over 100 updates per week on www.drugeruptiondata.com
Pneumonitis [8] Herpes zoster [2] Skin

Pulmonary toxicity [9] Hypomelanosis (<10%) Eczema [3]
Upper respiratory tract infection [8] Lupus erythematosus [3] Erythema multiforme [2]
Endocrine/Metabolic Photosensitivity [9] Exanthems (3%) [3]
ALT increased [7] Phototoxicity [7] Lichen planus [3]
AST increased [3] Pigmentation [3] Lichenoid eruption [9]
Diabetes mellitus [2] Porokeratosis (actinic) [3] Lupus erythematosus [14]
Gynecomastia [8] Pruritus (>10%) Peripheral edema (>10%)
Hypoalbuminemia [2] Rash (<10%) Photosensitivity [2]
Weight gain [2] Squamous cell carcinoma [4] Pigmentation [3]
Tumors [2] Seborrheic dermatitis [3]
Genitourinary Vitiligo [2] Urticaria [2]
Hair Mucosal
Renal Hypertrichosis [3] Oral lichenoid eruption [3]
Nephrotoxicity [25] Oral ulceration [6]
Renal failure [2] Nails
Nail pigmentation [5] Xerostomia (<10%)
Hematologic Photo-onycholysis [5] Central Nervous System
Anemia [8] Anxiety (<10%)
Febrile neutropenia [3] Mucosal
Cheilitis (<10%) Depression (<10%)
Hemotoxicity [2] Dyskinesia [2]
Leukopenia [10] Central Nervous System Fever (<10%)
Myelosuppression [6] Pain [2] Headache (<10%)
Myelotoxicity [4] Nightmares (<10%)
Neutropenia [9] Parkinsonism [2]
Pancytopenia [9]
METHOXYFLURANE Gastrointestinal/Hepatic
Hepatitis [2]
Ocular See: www.drugeruptiondata.com/drug/id/881 Hepatotoxicity [8]
Cotton wool spots [2]
Optic neuropathy [2] Endocrine/Metabolic
Amenorrhea [2]
Local METHSUXIMIDE Galactorrhea [4]
See: www.drugeruptiondata.com/drug/id/450 Hematologic
Other Hemolytic anemia [2]
Death [14]
Hodgkin’s disease (nodular sclerosing) [2] METHYCLOTHIAZIDE
Infection [23] METHYLERGONOVINE
Side effects [3] See: www.drugeruptiondata.com/drug/id/451
Teratogenicity [3] See: www.drugeruptiondata.com/drug/id/1871
METHYL SALICYLATE
METHOXSALEN METHYLNALTREXONE
Trade name: Oxsoralen (Valeant) See: www.drugeruptiondata.com/drug/id/2907
Indications: Psoriasis, vitiligo
Class: CYP1A2 inhibitor, Psoralen, Repigmenting METHYLDOPA
agent METHYLPHENIDATE
Half-life: 1.1 hours Trade name: Aldoclor (Merck)
Clinically important, potentially hazardous Indications: Hypertension Trade names: Concerta (Janssen), Metadate CD
interactions with: caffeine, chloroquine, Class: Adrenergic alpha-receptor agonist (Celltech), Methylin (Mallinckrodt), Ritalin
cyclosporine, fluoroquinolones, phenothiazines, Half-life: 1.7 hours (Novartis)
sulfonamides Clinically important, potentially hazardous Indications: Attention deficit disorder,
Pregnancy category: C interactions with: acebutolol, alfuzosin, narcolepsy
Important contra-indications noted in the bromocriptine, captopril, cilazapril, Class: Amphetamine
prescribing guidelines for: pediatric patients cyclopenthiazide, diclofenac, enalapril, ephedrine, Half-life: 24 hours
Note: Potential hazards of long-term therapy fosinopril, irbesartan, levodopa, Clinically important, potentially hazardous
include the possibilities of carcinogenicity and levomepromazine, linezolid, lisinopril, meloxicam, interactions with: amitriptyline, benazepril,
cataractogenicity. olmesartan, quinapril, ramipril, risperidone, bupropion, captopril, citalopram, clevidipine,
rotigotine, trandolapril, triamcinolone, cyclosporine, enalapril, escitalopram, irbesartan,
Skin zuclopenthixol linezolid, lisinopril, lurasidone, MAO inhibitors,
Anaphylactoid reactions/Anaphylaxis [2] Pregnancy category: B olmesartan, paliperidone, pantoprazole,
Basal cell carcinoma [3] Important contra-indications noted in the paroxetine hydrochloride, phenylbutazone,
Bullous dermatitis (with UVA) [4] prescribing guidelines for: nursing mothers pimozide, quinapril, safinamide, ziprasidone
Burning (<10%) [3] Note: Aldoril is methyldopa and Pregnancy category: C
Carcinoma [5] hydrochlorothiazide. Hydrochlorothiazide is a Important contra-indications noted in the
Dermatitis [4] sulfonamide and can be absorbed systemically. prescribing guidelines for: the elderly; nursing
Edema (<10%) Sulfonamides can produce severe, possibly fatal, mothers
Ephelides (<10%) [5] reactions such as toxic epidermal necrolysis and Warning: ABUSE AND DEPENDENCE
Erythema (<10%) Stevens-Johnson syndrome.
Exanthems [2]
Litt’s Drug Eruption & Reaction Manual METHYSERGIDE
Skin Hiccups [2]

Angioedema [2] METHYL- Infection [7]
Exanthems [2]
PREDNISOLONE
Hypersensitivity (<10%)
Leukoderma [2]
Trade names: Advantan (Intendis), Medrol METHYL-
(Pharmacia), Solu-Medrol (Pharmacia)
Mucosal Indications: Arthralgias, asthma, dermatoses, TESTOSTERONE
Xerostomia [7] inflammatory ocular conditions, rhinitis
Class: Corticosteroid, systemic Trade names: Android (Valeant), Estratest
Cardiovascular (Solvay), Testred (Valeant)
Cardiotoxicity [3] Half-life: 12–36 hours; 2–4 hours (plasma)
Clinically important, potentially hazardous Indications: Hypogonadism, impotence,
Palpitation [4] metastatic breast cancer
QT prolongation [2] interactions with: aminophylline, aprepitant,
aspirin, carbamazepine, clarithromycin, Class: Androgen
Tachycardia [5] Half-life: 2.53.5 hours
conivaptan, cyclosporine, daclizumab, darunavir,
Central Nervous System delavirdine, erythromycin, indinavir, itraconazole, Clinically important, potentially hazardous
Agitation [2] ketoconazole, live vaccines, oral contraceptives, interactions with: anticoagulants, cyclosporine,
Anorexia [7] phenobarbital, phenytoin, rifampin, telaprevir, warfarin
Anxiety [7] telithromycin, troleandomycin, voriconazole, Pregnancy category: X
Compulsions [2] warfarin Important contra-indications noted in the
Depression [2] Pregnancy category: C prescribing guidelines for: nursing mothers;
Fever [2] Important contra-indications noted in the pediatric patients
Hallucinations [6] prescribing guidelines for: nursing mothers;
Headache [12] pediatric patients Skin
Insomnia [14] Acneform eruption (>10%) [12]
Irritability [6] Edema (>10%)
Mood changes [2] Skin
Nervousness [2] Anaphylactoid reactions/Anaphylaxis [15] Hair
Neurotoxicity [3] Dermatitis [5] Alopecia [2]
Seizures [3] Hypersensitivity [3] Hirsutism (in females) (<10%) [9]
Somnolence (drowsiness) [3] Pruritus [2] Cardiovascular
Suicidal ideation [2] Rash [2] Flushing (<5%)
Tic disorder [6] Urticaria [5]
Endocrine/Metabolic
Tremor [2] Cardiovascular Mastodynia (>10%)
Vertigo (dizziness) [5] Arrhythmias [2]
Bradycardia [6] Genitourinary
Neuromuscular/Skeletal Priapism (>10%)
Asthenia (fatigue) [2] Flushing [2]
Dystonia [2] Hypertension [6]
Gastrointestinal/Hepatic Myocardial toxicity [2] METHYSERGIDE
Abdominal pain [12]
Nausea [7] Central Nervous System
Depression [5] Trade name: Sansert (Novartis)
Vomiting [5] Indications: Vascular (migraine) headaches
Respiratory Neurotoxicity [2] Class: Hallucinogen, Psychotomimetic
Cough [3] Psychosis [3] Half-life: 10 hours
Nasopharyngitis [4] Seizures [3] Clinically important, potentially hazardous
Upper respiratory tract infection [3] Vertigo (dizziness) [2] interactions with: acebutolol, almotriptan,
Endocrine/Metabolic amprenavir, azithromycin, chlortetracycline,
Neuromuscular/Skeletal clarithromycin, delavirdine, demeclocycline,
Appetite decreased [15] Arthralgia [2]
Weight loss [9] doxycycline, efavirenz, eletriptan, erythromycin,
Myalgia/Myopathy [4] frovatriptan, indinavir, itraconazole, lymecycline,
Genitourinary Osteonecrosis [9] minocycline, naratriptan, nelfinavir,
Priapism [5] Osteoporosis [2] oxytetracycline, ritonavir, rizatriptan, saquinavir,
Ocular Tendinopathy/Tendon rupture [2] sibutramine, sumatriptan, telithromycin,
Hallucinations, visual [6] Gastrointestinal/Hepatic tetracycline, tigecycline, troleandomycin,
Other Abdominal pain [3] voriconazole, zolmitriptan
Adverse effects [7] Gastrointestinal bleeding [2] Pregnancy category: X
Bruxism [2] Hepatotoxicity [8] Important contra-indications noted in the
Respiratory prescribing guidelines for: nursing mothers;
Dysphonia [2] pediatric patients
Endocrine/Metabolic
Hyperglycemia [4] Skin
Ocular Peripheral edema (<10%)
Cataract [3] Rash (<10%)
Glaucoma [2] Scleroderma [4]
Other Hair
Adverse effects [7] Alopecia [4]
Death [2] Cardiovascular
Valvulopathy [3]
METIPRANOLOL See all our books at www.crcpress.com
Otic
METIPRANOLOL METRONIDAZOLE Hearing loss [2]
See: www.drugeruptiondata.com/drug/id/998 Trade names: Flagyl (Pfizer), Metrocream Ocular
(Galderma), MetroGel (Galderma), Metrolotion Vision loss [2]
(Galderma), Noritate (Dermik), Vandazole Other
METOCLOPRAMIDE (Upsher-Smith)
Death [3]
See: www.drugeruptiondata.com/drug/id/456 susceptible organisms, rosacea Infection (fungal) (12%)
Class: Antibacterial, Antibiotic, nitroimidazole
METOLAZONE Clinically important, potentially hazardous

interactions with: alcohol, anisindione,
MEXILETINE
anticoagulants, astemizole, barbiturates, busulfan, See: www.drugeruptiondata.com/drug/id/460
See: www.drugeruptiondata.com/drug/id/457 cimetidine, dicumarol, disulfiram, dronabinol,
fluorouracil, lithium, lopinavir, mycophenolate,
phenytoin, primidone, thalidomide, tipranavir,
METOPROLOL uracil/tegafur, warfarin MEZLOCILLIN
Pregnancy category: B (in patients with
Trade names: Lopressor (Novartis), Toprol XL trichomoniasis, metronidazole is contra-indicated See: www.drugeruptiondata.com/drug/id/461
(AstraZeneca) during the first trimester of pregnancy)
Indications: Hypertension, angina pectoris Important contra-indications noted in the
Class: Adrenergic beta-receptor agonist, prescribing guidelines for: nursing mothers MIANSERIN
Antiarrhythmic class II
Half-life: 34 hours Skin See: www.drugeruptiondata.com/drug/id/1270
interactions with: cinacalcet, clonidine, Dermatitis [2]
alafenamide, cobicistat/elvitegravir/emtricitabine/
Exanthems (<5%) [2] MICAFUNGIN
Fixed eruption [14]
tenofovir disoproxil, dronedarone, epinephrine, Pruritus (<10%) [6] Trade name: Mycamine (Astellas)
mirabegron, paroxetine hydrochloride, Stevens-Johnson syndrome [4] Indications: Invasive candidiasis, esophageal
propoxyphene, tadalafil, telithromycin, tipranavir, Toxic epidermal necrolysis [2] candidiasis
venlafaxine, verapamil Urticaria [4] Class: Antifungal
Pregnancy category: C Half-life: 11–21 hours
Important contra-indications noted in the Mucosal
Glossitis [2] Clinically important, potentially hazardous
prescribing guidelines for: the elderly; pediatric interactions with: amphotericin B, conivaptan,
patients Tongue furry [2]
Xerostomia [2] cyclosporine, itraconazole, nifedipine, sirolimus
Note: Cutaneous side effects of beta-receptor Pregnancy category: C
blockers are clinically polymorphous. They Cardiovascular Important contra-indications noted in the
apparently appear after several months of Flushing [2] prescribing guidelines for: nursing mothers;
continuous therapy. Hypertension [2] pediatric patients
Skin Central Nervous System Skin
Eczema [2] Cerebellar syndrome [6] Anaphylactoid reactions/Anaphylaxis [2]
Erythroderma [2] Dysgeusia (taste perversion) [8] Peripheral edema (7%)
Lichenoid eruption [4] Encephalopathy [22] Pruritus (6%)
Pruritus (<5%) Fever [7] Rash (9%) [6]
Psoriasis (induction and aggravation of) [8] Headache (7%) [7] Ulcerations (5%)
Rash (<5%) [3] Neurotoxicity [13]
Raynaud’s phenomenon [3] Peripheral neuropathy [2] Mucosal
Psychosis [3] Epistaxis (nosebleed) (6%) [2]
Arrhythmias [2] Neuromuscular/Skeletal
Bradycardia [8] Ataxia [2] Cardiovascular
Hypotension [4] Bradycardia (3%)
Gastrointestinal/Hepatic Hypertension (7%) [2]
Central Nervous System Abdominal pain (5%) [8] Hypotension (9%)
Delirium [3] Diarrhea [15] Phlebitis (6%)
Hallucinations [2] Hepatotoxicity [5] Tachycardia (8%)
Sleep disturbances [2] Nausea [19]
Pancreatitis [6] Central Nervous System
Neuromuscular/Skeletal Anorexia (6%)
Asthenia (fatigue) [2] Vomiting [14]
Anxiety (6%)
Gastrointestinal/Hepatic Endocrine/Metabolic Fever (20%) [6]
Gastrointestinal disorder [2] ALT increased [2] Headache (16%) [3]
AST increased [2] Insomnia (10%)
Genitourinary
Peyronie’s disease [5] Genitourinary Rigors (9%)
Vulvovaginal candidiasis [2] Shock (8%)
Ocular
Hallucinations, visual [3] Hematologic Neuromuscular/Skeletal
Anemia [2] Asthenia (fatigue) (6%)
Bleeding [2] Back pain (5%)
Litt’s Drug Eruption & Reaction Manual MIDOSTAURIN
Gastrointestinal/Hepatic Central Nervous System

Abdominal pain (10%) [3] Chills (>5%) MIDODRINE
Constipation (11%) Gastrointestinal/Hepatic
Diarrhea (23%) [8] See: www.drugeruptiondata.com/drug/id/882
Nausea [2]
Dyspepsia (6%)
Hepatotoxicity [8] Local
Nausea (22%) [6] Injection-site pain (10%) MIDOSTAURIN *
Vomiting (22%) [5] Other
Respiratory Adverse effects [2] Trade name: Rydapt (Novartis)
Cough (8%) Indications: Aggressive systemic mastocytosis,
Dyspnea (6%) systemic mastocytosis with associated
hematological neoplasm, or mast cell leukemia,
Pneumonia (2%) MIDAZOLAM acute myeloid leukemia (FLT3 mutation-positive)
Endocrine/Metabolic in combination with cytarabine and daunorubicin
ALP increased (5%) [2] Trade name: Versed (Roche)
Indications: Preoperative sedation induction and cytarabine consolidation
ALT increased (5%) [6] Class: Multikinase inhibitor
AST increased (6%) [4] Class: Benzodiazepine
Half-life: 14 hours Half-life: 21 hours
Hyperbilirubinemia [3] Clinically important, potentially hazardous
Hyperglycemia (6%) Clinically important, potentially hazardous
interactions with: amprenavir, aprepitant, interactions with: boceprevir, carbamazepine,
Hyperkalemia (5%) clarithromycin, cobicistat, conivaptan, danoprevir,
Hypernatremia (5%) atazanavir, atorvastatin, boceprevir,
carbamazepine, chlorpheniramine, cimetidine, dasabuvir/ombitasvir/paritaprevir/ritonavir,
Hypocalcemia (7%) diltiazem, elvitegravir, enzalutamide, grapefruit
Hypoglycemia (6%) clarithromycin, clorazepate, CNS depressants,
cobicistat/elvitegravir/emtricitabine/tenofovir juice, idelalisib, indinavir, itraconazole,
Hypokalemia (18%) [3] ketoconazole, lopinavir, mitotane, nefazodone,
Hypomagnesemia (13%) alafenamide, cobicistat/elvitegravir/emtricitabine/
tenofovir disoproxil, conivaptan, darunavir, nelfinavir, ombitasvir/paritaprevir/ritonavir,
Hematologic dasabuvir/ombitasvir/paritaprevir/ritonavir, phenytoin, posaconazole, rifampin, ritonavir,
Anemia (10%) [3] delavirdine, dexamethasone, efavirenz, saquinavir, St John’s wort, stong CYP3A inducers
Febrile neutropenia (6%) enzalutamide, erythromycin, esomeprazole, and inhibitors, tipranavir, troleandomycin,
Hemolysis [3] fluconazole, fluoxetine, fosamprenavir, grapefruit voriconazole
Neutropenia (14%) juice, griseofulvin, imatinib, indinavir, itraconazole, Pregnancy category: N/A (May cause fetal
Sepsis (5%) ivermectin, ketoconazole, lopinavir, nelfinavir, toxicity based on findings in animal studies)
Thrombocytopenia (15%) [2] nevirapine, nilotinib, ombitasvir/paritaprevir/ Important contra-indications noted in the
Local ritonavir, phenobarbital, phenytoin, posaconazole, prescribing guidelines for: the elderly; nursing
Infusion-related reactions [2] primidone, ribociclib, rifabutin, rifampin, ritonavir, mothers; pediatric patients
Other roxithromycin, saquinavir, St John’s wort,

Adverse effects [5] telaprevir, telithromycin, tibolone, tipranavir, Skin
Infection (40%) voriconazole Cellulitis (5%)
Pregnancy category: D Edema (40%)
Erysipelas (5%)
Skin Hematoma (6%)
MICONAZOLE Edema [2] Herpes zoster (10%)
Pruritus [3] Hypersensitivity (4%)
Trade names: Monistat (Janssen), Oravig (Dara) Rash (14%)
Indications: Fungal infections, oropharyngeal Urticaria [2]
candidiasis Cardiovascular Mucosal
Class: Antibiotic, imidazole, Antifungal, azole Bradycardia [2] Epistaxis (nosebleed) (12%)
Half-life: initial: 40 minutes; terminal: 24 hours Hypotension [10] Oropharyngeal pain (4%)
Clinically important, potentially hazardous Central Nervous System Cardiovascular
interactions with: anisindione, anticoagulants, Agitation [3] Cardiac failure (6%)
astemizole, clopidogrel, dicumarol, gliclazide, Amnesia [38] Cardiotoxicity [2]
simvastatin, thioridazine, tolvaptan, vinblastine, Dysphoria [2] Hypotension (9%)
vincristine, warfarin Hallucinations [2] Myocardial infarction (4%)
Pregnancy category: C Sedation [2] Myocardial ischemia (4%)
Important contra-indications noted in the Vertigo (dizziness) [2] Pulmonary edema (3%)
prescribing guidelines for: nursing mothers; QT prolongation (11%) [3]
pediatric patients Gastrointestinal/Hepatic
Vomiting [3] Central Nervous System
Altered mental status (4%)
Skin Respiratory Chills (5%)
Angioedema (2%) Apnea [2] Fever (27%)
Contact dermatitis [2] Hypoxia [2] Headache (26%)
Dermatitis [11] Local Impaired concentration (7%)
Exanthems (287%) [5] Injection-site pain (>10%) Insomnia (11%)
Pruritus (236%) [3] Injection-site reactions (>10%) Tremor (6%)
Purpura (38%) Other Vertigo (dizziness) (13%)
Rash (9%) Adverse effects [7] Neuromuscular/Skeletal
Toxicity [2] Hiccups [3] Arthralgia (19%)
Urticaria (2%) Asthenia (fatigue) (34%) [4]
Cardiovascular Bone or joint pain (35%)
Flushing (<2%) [2] Gastrointestinal/Hepatic
Phlebitis (579%) [3] Abdominal pain (34%)
MIDOSTAURIN Over 100 updates per week on www.drugeruptiondata.com
Constipation (29%) [2] phenytoin, pimozide, posaconazole, quinidine, Other

Diarrhea (54%) [5] repaglinide, rifabutin, rifampin, rifapentine, Dipsia (thirst) (5–10%)
Dyspepsia (6%) ritonavir, ritonavir, saquinavir, simvastatin, Infection [2]
Gastritis (3%) sirolimus, St John’s wort, tacrolimus, telaprevir,
Gastrointestinal bleeding (14%) telithromycin, tenoxicam, triamcinolone,
Nausea (82%) [10] verapamil, voriconazole, warfarin
Vomiting (68%) [10] Pregnancy category: X
MIGLITOL
Respiratory Important contra-indications noted in the See: www.drugeruptiondata.com/drug/id/466
Bronchitis (6%) prescribing guidelines for: nursing mothers;
Cough (18%) pediatric patients
Dyspnea (23%) Note: Contra-indicated in pregnancy, with
Pleural effusion (13%) concurrent use of simvastatin or lovastatin and MIGLUSTAT
Pneumonia (10%) CYP3A substrates with narrow therapeutic range
or long-term corticosteroid use, and in women See: www.drugeruptiondata.com/drug/id/1006
Pneumonitis (2%)
Upper respiratory tract infection (30%) with a history of unexplained vaginal bleeding or
with endometrial hyperplasia with atypia or
Endocrine/Metabolic endometrial carcinoma. MILNACIPRAN
ALP increased (39%) Warning: TERMINATION OF PREGNANCY
ALT increased (31%) Trade name: Savella (Forest)
AST increased (32%) Indications: Fibromyalgia
GGT increased (35%) Skin
Edema (5–10%) Class: Antidepressant, Selective norepinepherine
Hyperamylasemia (20%) reuptake inhibitor
Hyperbilirubinemia (29%) Peripheral edema (26%)
Pruritus (4%) Half-life: 6–8 hours
Hyperglycemia (80%) [2] Clinically important, potentially hazardous
Hyperkalemia (23%) Rash (4%)
interactions with: alcohol, alpha / beta
Hyperuricemia (37%) Mucosal argonists, antipsychotics, aspirin, clomipramine,
Hypoalbuminemia (27%) Xerostomia (18%) clonidine, CNS-active drugs, digoxin, droperidol,
Hypocalcemia (39%) Cardiovascular epinephrine, levomepromazine, lithium, MAO
Hypokalemia (25%) [2] Chest pain (5–10%) inhibitors, norepinephrine, NSAIDs, serotonergic
Hypomagnesemia (20%) Hypertension (24%) drugs, sibutramine, St John’s wort, tryptophan,
Hyponatremia (34%) vitamin K antagonists
Hypophosphatemia (22%) Central Nervous System
Anorexia (10%) Pregnancy category: C
Serum creatinine increased (25%) Important contra-indications noted in the
Weight gain (6%) Anxiety (10%)
Chills (338%) prescribing guidelines for: the elderly; nursing
Genitourinary Fever (4%) mothers; pediatric patients
Urinary tract infection (16%) Headache (2–44%) Note: Contra-indicated in patients with
Renal Insomnia (5–10%) uncontrolled narrow-angle glaucoma.
Nephrotoxicity (11%) Pain (14%) Warning: SUICIDALITY AND
Somnolence (drowsiness) (10%) ANTIDEPRESSANT DRUGS
Hematologic
Anemia (60%) Vertigo (dizziness) (<22%)
Febrile neutropenia (8%) Neuromuscular/Skeletal Skin
Hyperlipasemia (37%) Arthralgia (30%) Hot flashes (12%)
Leukopenia (61%) Asthenia (fatigue) (<48%) Hyperhidrosis (9%) [6]
Lymphopenia (66%) Back pain (9–16%) Pruritus (2%)
Neutropenia (49%) Myalgia/Myopathy (14%) Rash (4%)
Sepsis (9%) Pain in extremities (12%) Mucosal
Thrombocytopenia (50%) Gastrointestinal/Hepatic Xerostomia (5%)
Abdominal pain (5–89%) [2] Cardiovascular
Constipation (10%) Chest pain (2%)
MIFEPRISTONE Diarrhea (12–20%) Flushing (4%)
Gastroesophageal reflux (5–10%) Hypertension (4%) [4]
Trade names: Korlym (Corcept), Mifeprex Nausea (43–61%) Palpitation (7%)
(Danco) Vomiting (16–26%) Tachycardia (2%) [2]
Indications: Medical termination of intrauterine Respiratory Central Nervous System
pregnancy (Mifeprex), Cushing’s syndrome in Dyspnea (16%) Anxiety (3%)
patients with Type II diabetes (Korlym) Nasopharyngitis (12%) Chills (2%)
Class: Corticosteroid antagonist, CYP3A4 Sinusitis (14%) Headache (17%) [7]
inhibitor, Progestogen antagonist Hypoesthesia (2%)
Adrenal insufficiency (4%) Insomnia (12%) [2]
Clinically important, potentially hazardous Migraine (4%)
interactions with: amprenavir, aprepitant, Appetite decreased (20%)
Hypoglycemia (5–10%) Paresthesias (3%)
atazanavir, boceprevir, bupropion, Serotonin syndrome [2]
carbamazepine, ciclesonide, ciprofloxacin, Hypokalemia (44%) [2]
Menstrual irregularities [2] Tremor (2%)
clarithromycin, conivaptan, cyclosporine, Vertigo (dizziness) (10%) [3]
darunavir, dihydroergotamine, diltiazem, Genitourinary
efavirenz, ergotamine, erythromycin, fentanyl, Metrorrhagia (5–10%) Gastrointestinal/Hepatic
fluconazole, fluvastatin, fosamprenavir, grapefruit Uterine pain (83%) Abdominal pain (3%)
juice, imatinib, indinavir, itraconazole, lopinavir, Vaginal bleeding (5–10%) Constipation (15%) [6]
lovastatin, mibefradil, nefazodone, nelfinavir, Vaginitis (3%) Nausea (39%) [17]
NSAIDs, oral contraceptives, phenobarbital, Vomiting (7%)
Litt’s Drug Eruption & Reaction Manual MINOXIDIL
Respiratory Pregnancy category: D Galactorrhea (black) [2]

Dyspnea (2%) Important contra-indications noted in the Thyroid dysfunction [2]
Upper respiratory tract infection (6%) prescribing guidelines for: nursing mothers; Otic
Endocrine/Metabolic pediatric patients Tinnitus [2]
Appetite decreased (2%) Ocular
Genitourinary Skin Conjunctival pigmentation [2]
Dysuria (>2%) [2] Anaphylactoid reactions/Anaphylaxis [3] Diplopia [2]
Ejaculatory dysfunction (>2%) [2] Angioedema [2] Papilledema [2]
Candidiasis [2] Scleral pigmentation [5]
Ocular Cellulitis [2]
Vision blurred (2%) DRESS syndrome [14] Other
Other Erythema multiforme [2] Adverse effects [4]
Adverse effects [3] Erythema nodosum [2] Tooth pigmentation (primarily in children)
Exanthems [5] (>10%) [22]
Fixed eruption [8]
MILRINONE Folliculitis [2] MINOXIDIL
Trade name: Primacor (Sanofi-Aventis)
Livedo reticularis [3] Trade names: Loniten (Par), Rogaine (Pfizer)
Indications: Severe congestive heart failure
Lupus erythematosus [50] (topical)
unresponsive to conventional maintenance
Photosensitivity (<10%) [9] Indications: Hypertension, androgenetic
therapy, acute heart failure, including low output
Pigmentation [123] alopecia
states following cardiac surgery
Pruritus [7] Class: Vasodilator
Class: Phosphodiesterase inhibitor
Purpura [4] Half-life: 4.2 hours
Rash [9] Clinically important, potentially hazardous
Raynaud’s phenomenon [2] interactions with: acebutolol, alcohol, alfuzosin,
interactions with: anagrelide
Serum sickness [4] captopril, cilazapril, diclofenac, enalapril,
Serum sickness-like reaction (35%) [6] fosinopril, guanethidine, levodopa,
Stevens-Johnson syndrome [2] levomepromazine, lisinopril, meloxicam,
Sweet’s syndrome [4] olmesartan, quinapril, ramipril, trandolapril,
pediatric patients
Urticaria [9] triamcinolone, trifluoperazine
Vasculitis [13] Pregnancy category: C
Cardiovascular Note: Topical [T].
Hypotension (<10%) [5]
Hair
Alopecia [2]
Supraventricular arrhythmias (<10%)
Vasodilation [2] Nails Skin
Ventricular tachycardia (<10%) Nail pigmentation (<5%) [19] Bullous dermatitis [2]
Photo-onycholysis [2] Dermatitis [T] (7%) [17]
Central Nervous System Eczema [2]
Headache (<10%) Mucosal Edema [T] (>10%) [2]
Black tongue [2] Exanthems [4]
Gingival pigmentation (8%) [2] Lupus erythematosus [3]
Oral pigmentation (7%) [22]
MILTEFOSINE Peripheral edema (7%)
Cardiovascular Pruritus [T] [10]
See: www.drugeruptiondata.com/drug/id/1336 Polyarteritis nodosa [12] Stevens-Johnson syndrome [2]
Central Nervous System Hair
Fever [2] Alopecia [T] [2]
MINOCYCLINE Headache [6] Hair pigmentation [2]
Intracranial pressure increased [4] Hirsutism (in women) (100%) [4]
Trade names: Dynacin (Medicis), Minocin Pseudotumor cerebri [14] Hypertrichosis (80100%) [22]
(Wyeth), Solodyn (Medicis) Vertigo (dizziness) [8] Cardiovascular
Indications: Various infections caused by Neuromuscular/Skeletal Palpitation [3]
susceptible organisms Arthralgia [6] Pericardial effusion [2]
Class: Antibiotic, tetracycline, Disease-modifying Asthenia (fatigue) [4]
antirheumatic drug (DMARD) Central Nervous System
Black bone disease [6] Headache [2]
Half-life: 1123 hours Myalgia/Myopathy [7]
Clinically important, potentially hazardous Vertigo (dizziness) [2]
interactions with: acitretin, aluminum, Gastrointestinal/Hepatic Respiratory
amoxicillin, ampicillin, antacids, bacampicillin, Abdominal pain [2] Pleural effusion [2]
BCG vaccine, bismuth, carbenicillin, cloxacillin, Diarrhea [2]
coumarins, digoxin, ergotamine, estradiol, Hepatitis [10]
estrogens, isotretinoin, kaolin, magnesium salts, Hepatotoxicity [20]
methotrexate, methoxyflurane, methysergide, Nausea [5]
mezlocillin, nafcillin, oral iron, oral typhoid Pancreatitis [2]
vaccine, oxacillin, penicillin G, penicillin V, Vomiting [3]
penicillins, phenindione, piperacillin, quinapril, Respiratory
retinoids, St John’s wort, strontium ranelate, Eosinophilic pneumonia [5]
sucralfate, sulfonylureas, ticarcillin, tripotassium Pneumonitis [2]
dicitratobismuthate, vitamin A, zinc Endocrine/Metabolic
Black thyroid syndrome [4]
MIRABEGRON See all our books at www.crcpress.com
Central Nervous System Vomiting [4]

MIRABEGRON Abnormal dreams (4%) Other
Anorexia (<10%) Adverse effects [6]
Trade name: Myrbetriq (Astellas) Cognitive impairment [2]
Indications: Overactive bladder Headache [2]
Class: Beta-3 adrenergic agonist Mania [2]
Half-life: 50 hours Neurotoxicity [3] MITOMYCIN
Clinically important, potentially hazardous Nightmares [2]
interactions with: antimuscarinics, desipramine, Restless legs syndrome [9] Synonyms: mitomycin-C; MTC
digoxin, flecainide, metoprolol, propafenone, Sedation [3] Trade name: Mutamycin (Bristol-Myers Squibb)
thioridazine Seizures [3] Indications: Carcinomas
Pregnancy category: C Serotonin syndrome [7] Class: Alkylating agent, Antibiotic, anthracycline
Important contra-indications noted in the Somnolence (drowsiness) (54%) [10] Half-life: 2378 minutes
prescribing guidelines for: nursing mothers; Tremor (<10%) [2] Clinically important, potentially hazardous
pediatric patients Vertigo (dizziness) (7%) [2] interactions with: aldesleukin
Neuromuscular/Skeletal Important contra-indications noted in the
Mucosal Arthralgia [4]
Xerostomia (3%) [3] prescribing guidelines for: nursing mothers;
Asthenia (fatigue) [7] pediatric patients
Cardiovascular Myalgia/Myopathy (<10%)
Hypertension (8–11%) [7] Rhabdomyolysis [4]
Tachycardia (<2%) [3] Skin
Gastrointestinal/Hepatic Dermatitis [9]
Central Nervous System Abdominal pain (<10%) Erythema multiforme [2]
Headache (2–4%) [4] Constipation (<10%) [2] Exanthems [2]
Vertigo (dizziness) (3%) Hepatotoxicity [3] Exfoliative dermatitis [2]
Neuromuscular/Skeletal Pancreatitis [2] Hand–foot syndrome [2]
Arthralgia (<2%) Vomiting (<10%) Thrombocytopenic purpura [2]
Back pain (3%) Respiratory Hair
Gastrointestinal/Hepatic Flu-like syndrome (<10%) Alopecia (<10%)
Constipation (2–3%) [4] Endocrine/Metabolic Nails
Diarrhea (<2%) ALT increased (2%) Nail pigmentation (purple) (<10%)
Gastrointestinal disorder [2] Appetite increased (12%) [2]
Galactorrhea [2] Mucosal
Respiratory Oral lesions (28%) [4]
Influenza (3%) Gynecomastia [2]
Weight gain (12%) [9] Oral ulceration (<10%)
Nasopharyngitis (4%) [2] Stomatitis (>10%)
Sinusitis (<3%) Other
Upper respiratory tract infection (2%) Adverse effects [2] Cardiovascular
Congestive heart failure (3–15%)
Genitourinary
Cystitis (2%) Central Nervous System
Urinary tract infection (3–6%) [4] MISOPROSTOL Anorexia (14%)
Fever (14%)
Other Paresthesias (<10%)
Adverse effects [3] Trade names: Arthrotec (Pfizer), Cytotec
(Pfizer) Neuromuscular/Skeletal
Indications: Prevention of NSAID-induced ulcer Asthenia (fatigue) [2]
Class: Corticosteroid antagonist, Progestogen Gastrointestinal/Hepatic
MIRTAZAPINE antagonist Nausea (14%)
Half-life: 2040 minutes Vomiting (14%)
Trade name: Remeron (Organon) Clinically important, potentially hazardous
Indications: Depression interactions with: none known Respiratory
Class: Adrenergic alpha-receptor agonist, Pregnancy category: X Cough (7%)
Antidepressant, tetracyclic Important contra-indications noted in the Renal
Half-life: 2040 hours prescribing guidelines for: nursing mothers; Nephrotoxicity [2]
interactions with: linezolid, tapentadol, Hematologic
Note: Arthrotec is diclofenac and misoprostol. Anemia (19–24%)
venlafaxine
Pregnancy category: C Hemolytic uremic syndrome [41]
Warning: SUICIDALITY AND Skin Neutropenia [2]
ANTIDEPRESSANT DRUGS Anaphylactoid reactions/Anaphylaxis [2] Ocular
Central Nervous System Epiphora [2]
Skin Chills [7] Keratitis [2]
Diaphoresis [2] Dysgeusia (taste perversion) [2] Ocular toxicity [3]
Edema (<10%) [2] Fever [13] Local
Peripheral edema (<10%) Headache (2%) Injection-site cellulitis (>10%)
Pigmentation [2] Shivering (17%) [8] Injection-site necrosis (>10%) [3]
Rash (<10%) Gastrointestinal/Hepatic
Mucosal Abdominal pain (7%) [7]
Glossitis (<10%) Diarrhea (13%) MITOTANE
Xerostomia (25%) [3] Dyspepsia (2%)
Flatulence (3%) See: www.drugeruptiondata.com/drug/id/473
Nausea (3%) [4]
Litt’s Drug Eruption & Reaction Manual MORPHINE
MITOXANTRONE MOCLOBEMIDE MONTELUKAST

Trade name: Novantrone (OSI) See: www.drugeruptiondata.com/drug/id/1275 Trade name: Singulair (Merck)
Indications: Acute myelogenous leukemia, Indications: Asthma
multiple sclerosis, prostate cancer Class: Leukotriene receptor antagonist
Class: Antibiotic, anthracycline, Antineoplastic
Half-life: median terminal: 75 hours
MODAFINIL Half-life: 2.75.5 hours
Clinically important, potentially hazardous Trade name: Provigil (Cephalon) interactions with: prednisone
interactions with: aldesleukin, safinamide Indications: Narcolepsy Pregnancy category: B
Pregnancy category: D Class: Analeptic, CNS stimulant, CYP1A2 Important contra-indications noted in the
Important contra-indications noted in the inducer, CYP3A4 inducer prescribing guidelines for: nursing mothers
prescribing guidelines for: nursing mothers; Half-life: ~15 hours
pediatric patients Clinically important, potentially hazardous Skin
interactions with: elbasvir & grazoprevir, Angioedema [3]
Skin enzalutamide, neratinib, olaparib, oral Churg-Strauss syndrome [27]
Diaphoresis (<10%) contraceptives, palbociclib, sonidegib, Rash (2%) [2]
Ecchymoses (7%) thalidomide, venetoclax Urticaria (2%)
Edema (>10%) Pregnancy category: C Central Nervous System
Fungal dermatitis (>15%) Important contra-indications noted in the Aggression [3]
Peripheral edema [2] prescribing guidelines for: the elderly; nursing Anxiety [2]
Petechiae (>10%) mothers; pediatric patients Depression [2]
Purpura (>10%) Hallucinations [2]
Hair Skin Headache [4]
Alopecia (2060%) [6] Fixed eruption [2] Irritability [2]
Cardiovascular Mucosal Neurotoxicity [5]
Cardiac failure [2] Xerostomia (5%) Nightmares [2]
Cardiotoxicity [4] Sleep disturbances [3]
Cardiovascular Suicidal ideation [2]
Congestive heart failure [3] Hypertension [2]
Central Nervous System Palpitation [2] Gastrointestinal/Hepatic
Chills (<10%) Abdominal pain [2]
Central Nervous System Hepatotoxicity [3]
Gastrointestinal/Hepatic Agitation [2]
Diarrhea [2] Chills (2%) Respiratory
Nausea [6] Hallucinations [2] Cough [2]
Vomiting [3] Headache (28%) [13] Flu-like syndrome (<10%)
Endocrine/Metabolic Insomnia (5%) [6] Other
Amenorrhea [4] Nervousness [2] Adverse effects [3]
Menstrual irregularities [2] Paresthesias (3%)
Psychosis [2]
Genitourinary Vertigo (dizziness) (5%) [3]
Urinary tract infection [2] MORICIZINE
Hematologic Back pain (6%) See: www.drugeruptiondata.com/drug/id/478
Anemia [2]
Febrile neutropenia [2] Gastrointestinal/Hepatic
Leukemia [4] Abdominal pain [2]
Leukopenia [4] Diarrhea (6%) [3] MORPHINE
Neutropenia [6] Nausea (11%) [6]
Thrombocytopenia [2] Respiratory Trade names: Avinza (Ligand), Duramorph
Rhinitis (7%) (Baxter) (Elkins-Sinn), Infumorph (Baxter), Kadian
Other (aaiPharma), Morphabond (Inspirion), MS Contin
Death [2] Ocular (Purdue), MSIR Oral (Purdue), Roxanol
Infection (>66%) [3] Hallucinations, visual [2] (aaiPharma)
Other Indications: Severe pain, acute myocardial
Adverse effects [3] infarction
MIVACURIUM Class: Opiate agonist
Half-life: 24 hours
See: www.drugeruptiondata.com/drug/id/1335 MOEXIPRIL interactions with: buprenorphine, cimetidine,
See: www.drugeruptiondata.com/drug/id/475 furazolidone, MAO inhibitors, metformin,
mianserin, pentazocine, rifapentine, trospium
MIZOLASTINE
See: www.drugeruptiondata.com/drug/id/1393 MOLINDONE
MIZORIBINE
See: www.drugeruptiondata.com/drug/id/1264 MOMETASONE
MORPHINE Over 100 updates per week on www.drugeruptiondata.com
Pregnancy category: C lanthanum, levomepromazine, magnesium salts,

Important contra-indications noted in the mefloquine, mizolastine, mycophenolate, MOXISYLYTE
prescribing guidelines for: nursing mothers; nilotinib, NSAIDs, oral iron, oral typhoid vaccine,
pediatric patients pentamidine, phenothiazines, pimavanserin, See: www.drugeruptiondata.com/drug/id/1350
Warning: ADDICTION, ABUSE, AND MISUSE; pimozide, probenecid, procainamide, QT
LIFETHREATENING RESPIRATORY prolonging agents, quinapril, quinidine, quinine,
DEPRESSION; ACCIDENTAL INGESTION; ribociclib, sevelamer, sotalol, strontium ranelate, MOXONIDINE
NEONATAL OPIOID WITHDRAWAL sucralfate, sulfonylureas, tetrabenazine,
SYNDROME; and INTERACTION WITH thioridazine, tricyclic antidepressants, vandetanib, See: www.drugeruptiondata.com/drug/id/1392
ALCOHOL vitamin K antagonists, warfarin, zinc, ziprasidone,
zolmitriptan, zuclopenthixol
Skin
MUPIROCIN
AGEP [3]
Edema [2] prescribing guidelines for: the elderly; nursing See: www.drugeruptiondata.com/drug/id/935
Pruritus (565%) [36] mothers; pediatric patients
Note: Fluoroquinolones are associated with an
Mucosal increased risk of tendinitis and tendon rupture in
Xerostomia (>10%) [8] all ages. This risk is further increased in older MUROMONAB-CD3
Cardiovascular patients usually over 60 years of age, in patients
Cardiotoxicity [3] taking corticosteroid drugs, and in patients with See: www.drugeruptiondata.com/drug/id/1251
Hypotension [5] kidney, heart or lung transplants.
Central Nervous System Fluoroquinolones may exacerbate muscle
Allodynia [4] weakness in persons with myasthenia gravis. MYCOPHENOLATE
Confusion [2] Moxeza is for topical ophthalmic use only.
Hallucinations [4] Warning: SERIOUS ADVERSE REACTIONS Synonyms: mycophenolate mofetil,
Hyperalgesia [10] INCLUDING TENDINITIS, TENDON mycophenolate sodium
Sedation [2] RUPTURE, PERIPHERAL NEUROPATHY, Trade names: CellCept (Roche), Myfortic
Somnolence (drowsiness) [4] CENTRAL NERVOUS SYSTEM EFFECTS and (Novartis)
Trembling (<10%) EXACERBATION OF MYASTHENIA GRAVIS Indications: Prophylaxis of organ rejection
Vertigo (dizziness) [5] Class: Immunosuppressant
Skin Half-life: 18 hours
Neuromuscular/Skeletal Clinically important, potentially hazardous
Myoclonus [5] AGEP [2]
Anaphylactoid reactions/Anaphylaxis [5] interactions with: antacids, azathioprine,
Rhabdomyolysis [2] basiliximab, belatacept, cholestyramine,
Bullous dermatitis [2]
Gastrointestinal/Hepatic Hypersensitivity [6] ciprofloxacin, corticosteroids, cyclophosphamide,
Constipation [7] Photosensitivity [5] cyclosporine, daclizumab, gemifloxacin,
Nausea [14] Pruritus [3] Hemophilus B vaccine, levofloxacin,
Vomiting [11] Rash [4] mercaptopurine, metronidazole, moxifloxacin,
Respiratory Thrombocytopenic purpura [2] norfloxacin, ofloxacin, pantoprazole, rifapentine,
Respiratory depression [5] Toxic epidermal necrolysis [2] sevelamer, tacrolimus, vaccines
Urticaria [3] Pregnancy category: D
Endocrine/Metabolic Important contra-indications noted in the
Amenorrhea [2] Cardiovascular prescribing guidelines for: the elderly; nursing
Phlebitis [2] mothers; pediatric patients
Genitourinary
QT prolongation [13] Warning: EMBRYOFETAL TOXICITY,
Urinary retention [2]
Torsades de pointes [7] MALIGNANCIES AND SERIOUS INFECTIONS
Local
Injection-site pain (>10%)
Dysgeusia (taste perversion) [3] Skin
Other Hallucinations [2]
Adverse effects [2] Acneform eruption (>10%) [3]
Headache (4%) [5] Carcinoma (non-melanoma) (4%)
Death [3] Somnolence (drowsiness) [2]
Hiccups [3] Edema (12%)
Vertigo (dizziness) (3%) [6] Herpes simplex [3]
Neuromuscular/Skeletal Herpes zoster [6]
Myasthenia gravis (exacerbation) [2] Peripheral edema (29%)
MOXIFLOXACIN Tendinopathy/Tendon rupture [3] Rash (8%) [2]
Gastrointestinal/Hepatic Warts [2]
Trade names: Avelox (Bayer), Moxeza (Alcon)
Abdominal pain [5] Hair
Diarrhea (6%) [6] Alopecia [3]
Class: Antibiotic, fluoroquinolone
Gastrointestinal disorder [2] Mucosal
Half-life: 12 hours
Hepatotoxicity [3] Gingival hyperplasia/hypertrophy [2]
Nausea (7%) [9] Oral candidiasis (10%)
interactions with: alfuzosin, aminophylline,
Vomiting [5] Oral ulceration [5]
amiodarone, amitriptyline, antacids, arsenic, Local Cardiovascular
artemether/lumefantrine, asenapine, Injection-site reactions [2] Hypertension [4]
atomoxetine, BCG vaccine, benperidol, bepridil, Other Thrombophlebitis (<10%)
bretylium, chloroquine, ciprofloxacin, Adverse effects [8]
corticosteroids, cyclosporine, degarelix, Central Nervous System
didanosine, disopyramide, dronedarone, Fever [3]
droperidol, erythromycin, gadobutrol, Headache (>20%) [5]
haloperidol, hydroxychloroquine, insulin, Insomnia [3]
Litt’s Drug Eruption & Reaction Manual MYCOPHENOLATE
Leukoencephalopathy [4] Nausea [5] Hematologic

Neurotoxicity [2] Vomiting [5] Anemia (>20%)
Pain (>20%) Respiratory Bone marrow suppression [2]
Tremor (11%) Bronchitis [2] Dyslipidemia [2]
Neuromuscular/Skeletal Cough [2] Leukopenia [4]
Arthralgia [4] Upper respiratory tract infection [3] Lymphopenia [3]
Asthenia (fatigue) [6] Myelotoxicity [2]
Endocrine/Metabolic Neutropenia [4]
Back pain (6%) Hyperglycemia [4]
Myalgia/Myopathy [4] Thrombocytopenia [4]
Hyperlipidemia [3]
Gastrointestinal/Hepatic Other
Genitourinary Adverse effects [19]
Abdominal distension [2] Urinary tract infection [2]
Abdominal pain [6] Death [2]
Colitis [3] Renal Infection (1220%) [18]
Diarrhea [13] Nephrotoxicity [3] Teratogenicity [4]
Hepatotoxicity [5]
NABILONE See all our books at www.crcpress.com
Vomiting (3–9%)
NABILONE Endocrine/Metabolic
NALBUPHINE
Trade name: Cesamet (Valeant) Pseudoporphyria [8] Trade name: Nubain (Endo)
Indications: Nausea and vomiting Renal Indications: Moderate to severe pain
Class: Antiemetic, Cannabinoid Nephrotoxicity [2] Class: Opiate agonist
Half-life: 2 hours Otic Half-life: 5 hours
Clinically important, potentially hazardous Tinnitus (<10%) Clinically important, potentially hazardous
interactions with: CNS depressants interactions with: CNS depressants, diazepam,
Pregnancy category: C Other hydrocodone, hydromorphone, oxymorphone,
Adverse effects [6] pentobarbital, promethazine, tapentadol
Mucosal Pregnancy category: B
Xerostomia [6] Note: Nalbuphine contains sulfites.
Cardiovascular
NADOLOL
Hypotension [8] Skin
Trade name: Corzide (Monarch) Clammy skin (9%)
Central Nervous System Indications: Hypertension, angina pectoris Diaphoresis (9%)
Dyskinesia [3] Class: Adrenergic beta-receptor antagonist,
Somnolence (drowsiness) [2] Antiarrhythmic class II Mucosal
Vertigo (dizziness) [15] Half-life: 1024 hours Xerostomia (4%)
Neuromuscular/Skeletal Clinically important, potentially hazardous Central Nervous System
Asthenia (fatigue) [5] interactions with: clonidine, epinephrine, Vertigo (dizziness) (5%)
verapamil Local
Pregnancy category: C Injection-site pain [4]
NABUMETONE prescribing guidelines for: nursing mothers;
pediatric patients
Trade name: Relafen (GSK) Note: Corzide is nadolol and NALDEMEDINE *
Indications: Arthritis bendroflumethiazide. Cutaneous side effects of
Class: Non-steroidal anti-inflammatory (NSAID) beta-receptor blockers are clinically Trade name: Symproic (Shionogi)
Half-life: 22.530 hours polymorphous. They apparently appear after Indications: Opioid-induced constipation in adult
Clinically important, potentially hazardous several months of continuous therapy. Contra- patients with chronic non-cancer pain
interactions with: methotrexate indicated in patients with bronchial asthma, sinus Class: Opioid antagonist
Pregnancy category: C bradycardia and greater than first degree Half-life: 11 hours
Important contra-indications noted in the conduction block, cardiogenic shock, and overt Clinically important, potentially hazardous
prescribing guidelines for: nursing mothers; cardiac failure. interactions with: amiodarone, aprepitant,
pediatric patients atazanavir, captopril, carbamazepine,
Note: NSAIDs may cause an increased risk of clarithromycin, cyclosporine, diltiazem,
serious cardiovascular and gastrointestinal Skin erythromycin, fluconazole, itraconazole,
adverse events, which can be fatal. This risk may Edema (<5%) ketoconazole, moderate or strong CYP3A
increase with duration of use. Psoriasis [4] inhibitors, other opioid antagonists, P-gp
Warning: CARDIOVASCULAR AND Raynaud’s phenomenon (2%) [2] inhibitors, phenytoin, quercetin, quinidine,
GASTROINTESTINAL RISKS Cardiovascular rifampin, ritonavir, saquinavir, St John’s wort,
Bradycardia (2%) strong CYP3A inducers, verapamil
Skin Central Nervous System Pregnancy category: N/A (Potential for opioid
Diaphoresis (<3%) Hypoesthesia (fingers and toes) (>5%) withdrawal in fetus)
Edema (39%) Paresthesias (>5%) Important contra-indications noted in the
Erythema [2] Vertigo (dizziness) (2%) prescribing guidelines for: nursing mothers;
Hypersensitivity [3] pediatric patients
Neuromuscular/Skeletal Note: Contra-indicated in patients with known
Photosensitivity [2] Asthenia (fatigue) (2%)
Pruritus (39%) [2] or suspected gastrointestinal obstruction. Opioid
Rash (39%) [4] Other withdrawal symptoms have occurred in patients
Adverse effects [4] treated with naldemedine.
Mucosal
Stomatitis (<3%)
Xerostomia (<3%) Skin
NAFARELIN Hypersensitivity (<2%)
Rash (<2%)
Headache (3–9%) [2] See: www.drugeruptiondata.com/drug/id/484
Insomnia (3–9%) Gastrointestinal/Hepatic
Nervousness (3–9%) Abdominal pain (8–11%)
Somnolence (drowsiness) (3–9%) Diarrhea (7%) [2]
Vertigo (dizziness) (3–9%) NAFCILLIN Gastroenteritis (2–3%)
Nausea (4–6%)
Gastrointestinal/Hepatic See: www.drugeruptiondata.com/drug/id/485 Vomiting (3%)
Constipation (3–9%) Respiratory
Diarrhea (14%) [5] Bronchospasm (<2%)
Dyspepsia (13%) [4] Other
Flatulence (3–9%) Adverse effects [3]
Gastrointestinal ulceration [3]
Hepatotoxicity [2]
Nausea (3–9%) [2]
Litt’s Drug Eruption & Reaction Manual NAPROXEN
Cardiovascular Nausea [7]

NALIDIXIC ACID Arrhythmias [2] Vomiting [5]
Bradycardia [2] Respiratory
See: www.drugeruptiondata.com/drug/id/486 Hypertension [8] Influenza [2]
Hypotension [2] Nasopharyngitis [2]
Pulmonary edema [2]
NALMEFENE Local
Central Nervous System Injection-site pain [2]
Headache [4] Injection-site reactions [4]
See: www.drugeruptiondata.com/drug/id/1303 Seizures [5]
Somnolence (drowsiness) [3] Other
Adverse effects [3]
NALOXEGOL Asthenia (fatigue) [3]
Myoclonus [2]
Trade name: Movantik (AstraZeneca)
NANDROLONE
Indications: Opioid-induced constipation
Class: Opioid receptor antagonist Constipation [6] Trade name: Deca-Durabolin (Organon)
Half-life: 6–11 hours Nausea [3] Indications: Anemia of renal insufficiency,
Clinically important, potentially hazardous Vomiting [2] control of metastatic breast cancer, osteoporosis
interactions with: diltiazem, erythromycin, Other in post-menopausal women
grapefruit juice, verapamil Adverse effects [4] Class: Anabolic steroid
Pregnancy category: C Death [2] Half-life: 6–14 days
prescribing guidelines for: nursing mothers; interactions with: acenocoumarol, anisindione,
pediatric patients anticoagulants, dabigatran, danaparoid,
Note: Contra-indicated in patients with known
NALTREXONE fondaparinux, heparin, warfarin
or suspected gastrointestinal obstruction, patients Trade names: Contrave (Takeda), Depade Pregnancy category: X
at increased risk of recurrent gastrointestinal (Mallinckrodt), Nalorex (Bristol-Myers Squibb), Important contra-indications noted in the
obstruction, and patients concomitantly using Opizone (Genus), ReVia (Meda), Troxyca (Pfizer), prescribing guidelines for: nursing mothers;
strong CYP3A4 inhibitors. Vivitrex (Alkermes), Vivitrol (Alkermes) pediatric patients
Indications: Substance abuse, opioid Note: Deca Durabolin contains Arachis oil
Skin dependence, alcohol dependence (peanut oil) and should not be taken / applied by
Hyperhidrosis (<3%) Class: Opioid antagonist patients known to be allergic to peanut.
Central Nervous System Half-life: 4 hours

Headache (4%) [3] Clinically important, potentially hazardous Hair
interactions with: opioid analgesics, opioid Hirsutism [3]
Gastrointestinal/Hepatic containing medications
Abdominal pain (12–21%) [5] Other
Pregnancy category: C Adverse effects [2]
Diarrhea (6–9%) [5] Important contra-indications noted in the
Flatulence (3–6%) [2] prescribing guidelines for: nursing mothers;
Nausea (7–8%) [5] pediatric patients
Vomiting (3–5%) Note: Naltrexone has the capacity to cause NAPHAZOLINE
Other hepatocellular injury when given in excessive
Adverse effects [2] doses. See: www.drugeruptiondata.com/drug/id/2195
Troxyca is naltrexone and oxycodone. Contra-
indicated in acute hepatitis or liver failure; patients
NALOXONE receiving opioid analgesics, with current NAPROXEN
physiologic opioid dependence, or in acute opioid
Trade names: Suboxone (Reckitt Benckiser), withdrawal. Trade names: Aleve (Bayer), Naprosyn (Roche),
Talwin-NX (Sanofi-Aventis), Targiniq (Purdue) Synflex (Roche)
Indications: Narcotic overdose Skin Indications: Pain, arthritis
Class: Opioid antagonist Pruritus [2] Class: Non-steroidal anti-inflammatory (NSAID)
Half-life: <1.5 hours Rash (<10%) Half-life: 15 hours
Cardiovascular interactions with: methotrexate, methyl
interactions with: cobicistat/elvitegravir/ Hypertension [3]
emtricitabine/tenofovir alafenamide, cobicistat/ salicylate, prednisolone
elvitegravir/emtricitabine/tenofovir disoproxil, Central Nervous System Pregnancy category: C
thioridazine Chills (<10%) Important contra-indications noted in the
Pregnancy category: C Compulsions [2] prescribing guidelines for: the elderly; nursing
Important contra-indications noted in the Depression [2] mothers; pediatric patients
prescribing guidelines for: nursing mothers Headache [3] Note: NSAIDs may cause an increased risk of
Note: Subuxone contains buprenorphine; Insomnia [3] serious cardiovascular and gastrointestinal
Targiniq is naloxone and oxycodone. Seizures [2] adverse events, which can be fatal. This risk may
Vertigo (dizziness) [4] increase with duration of use.
Diaphoresis (<10%) Arthralgia (>10%) Skin
Pruritus [2] Asthenia (fatigue) [3] Anaphylactoid reactions/Anaphylaxis [2]
Rash (<10%) Gastrointestinal/Hepatic Angioedema [5]
Mucosal Constipation [5]
Diaphoresis (<3%) [3]
Xerostomia [2] Hepatotoxicity [5]
DRESS syndrome [4]
NAPROXEN Over 100 updates per week on www.drugeruptiondata.com
Ecchymoses (39%) Respiratory

Edema (<9%) NATALIZUMAB Flu-like syndrome (4%)
Exanthems (<14%) [9] Synonym: antegren
Fixed eruption [25] Trade name: Tysabri (Biogen)
Hypersensitivity [2] Indications: Multiple sclerosis, Crohn’s disease NEBIVOLOL
Lichen planus [3] Class: Immunomodulator, Monoclonal antibody
Half-life: 11 days Trade names: Bystolic (Forest), Byvalson
Lichenoid eruption [3] (Forest), Nebilet (Menarini)
Lupus erythematosus [2] Clinically important, potentially hazardous
interactions with: abatacept, alefacept, Indications: Hypertension
Photosensitivity [16] Class: Adrenergic beta-receptor antagonist, Beta
Pruritus (317%) [5] azacitidine, azathioprine, betamethasone,
cabazitaxel, certolizumab, cortocosteroids, blocker
Purpura (<3%) [4] Half-life: 8 hours
Pustules [2] cyclosporine, denileukin, docetaxel, fingolimod,
gefitinib, leflunomide, lenalidomide, Clinically important, potentially hazardous
Rash (39%) [2] interactions with: beta blockers, cinacalcet,
Toxic epidermal necrolysis [5] mercaptopurine, methotrexate, oxaliplatin,
pazopanib, pemetrexed, rilonacept, temsirolimus, clonidine, CYP2D6 inhibitors, delavirdine, digitalis
Urticaria (<5%) [6] glycosides, duloxetine, terbinafine, tipranavir
Vasculitis [9] triamcinolone, vedolizumab
Hair Important contra-indications noted in the Important contra-indications noted in the
Alopecia [3] prescribing guidelines for: nursing mothers; prescribing guidelines for: nursing mothers;
Mucosal pediatric patients pediatric patients
Stomatitis (<3%) Note: Contra-indicated in patients who have or Note: Byvalson is nebivolol and valsartan.
Xerostomia [2] have had progressive multifocal Warning: Byvalson: FETAL TOXICITY
Cardiovascular leukoencephalopathy.
Chest pain [2] Warning: PROGRESSIVE MULTIFOCAL Cardiovascular
Myocardial infarction [2] LEUKOENCEPHALOPATHY Bradycardia [3]
Central Nervous System Central Nervous System
Somnolence (drowsiness) [2] Skin Headache (6–9%) [9]
Vertigo (dizziness) [6] Dermatitis (6%) Vertigo (dizziness) (2–4%) [5]
Herpes simplex [2] Neuromuscular/Skeletal
Neuromuscular/Skeletal Hypersensitivity [6]
Leg cramps [2] Asthenia (fatigue) (2–5%) [4]
Pruritus (4%)
Gastrointestinal/Hepatic Rash (9%) Gastrointestinal/Hepatic
Abdominal pain [4] Diarrhea (<2%)
Central Nervous System Nausea (<3%)
Constipation [2] Depression (17%)
Diarrhea [3] Headache (35%) [3] Respiratory
Dyspepsia [9] Leukoencephalopathy [77] Nasopharyngitis [3]
Hepatotoxicity [4] Tremor (3%) Upper respiratory tract infection [3]
Nausea [10] Other
Respiratory Asthenia (fatigue) (24%) [4] Adverse effects [3]
Nasopharyngitis [2]
Endocrine/Metabolic Hepatotoxicity [4]
Pseudoporphyria [29]
Genitourinary
NECITUMUMAB
Renal Vaginitis (8%)
Nephrotoxicity [3] Trade name: Portrazza (Lilly)
Local Indications: Metastatic squamous non-small cell
Hematologic Application-site reactions (22%) lung cancer (in combination with cisplatin and
Thrombocytopenia [2] Infusion-related reactions [3] gemcitabine)
Otic Infusion-site reactions [2] Class: Epidermal growth factor receptor (EGFR)
Tinnitus [2] Other inhibitor, Monoclonal antibody
Other Adverse effects [4] Half-life: 14 days
Adverse effects [10] Allergic reactions (7%) [4] Clinically important, potentially hazardous
Death [2] Death [6] interactions with: none known
Side effects (59%) [3] Infection (2%) [3] Pregnancy category: N/A (Can cause fetal
harm)
NARATRIPTAN NATEGLINIDE pediatric patients
Note: See separate entries for cisplatin and
See: www.drugeruptiondata.com/drug/id/489 Trade name: Starlix (Novartis) gemcitabine.
Indications: Diabetes Type II Warning: CARDIOPULMONARY ARREST and
Class: Meglitinide HYPOMAGNESEMIA
interactions with: none known Skin
Pregnancy category: C Acneform eruption (9–15%)
Important contra-indications noted in the Fissures (5%)
prescribing guidelines for: nursing mothers; Hypersensitivity (2%)
pediatric patients Pruritus (7%) [2]
Rash (44%) [9]
Toxicity (8%) [2]
Litt’s Drug Eruption & Reaction Manual NEPAFENAC
Xerosis (7%) [2] barbiturates, benzodiazepines, brigatinib,

Skin
Mucosal cabazitaxel, cabozantinib, calcifediol,
Stomatitis (11%) carbamazepine, chlordiazepoxide, ciclesonide,
Contact dermatitis (<10%) [72]
cisapride, clonazepam, clorazepate, copanlisib,
Cardiovascular Eczema [2]
crizotinib, cyclosporine, darifenacin, dasatinib,
Cardiac arrest (3%) Exanthems [2]
delavirdine, diazepam, dihydroergotamine,
Phlebitis (2%) Rash (<10%)
eletriptan, eplerenone, ergot alkaloids,
Venous thromboembolism (9%) [4] Toxic epidermal necrolysis [2]
ergotamine, erlotinib, estrogens, eszopiclone,
Urticaria (<10%)
Central Nervous System etravirine, eucalyptus, everolimus, fentanyl,
Headache (11%) [2] fesoterodine, flibanserin, flurazepam, fluticasone Otic
propionate, indinavir, ivabradine, ixabepilone, Hearing loss [3]
Asthenia (fatigue) [3] lapatinib, lomitapide, lopinavir, lorazepam,
Muscle spasm (2%) lovastatin, maraviroc, methadone,
methylergonovine, methysergide, midazolam, NEOSTIGMINE
midostaurin, mifepristone, neratinib, olaparib,
Diarrhea (16%) [2] omeprazole, oral contraceptives, oxazepam, Trade name: Prostigmin (Valeant)
Dysphagia (3%) paclitaxel, palbociclib, pantoprazole, pazopanib, Indications: Myasthenia gravis
Vomiting (29%) phenytoin, pimozide, ponatinib, primidone, Class: Acetylcholinesterase inhibitor,
Respiratory progestogens, quazepam, quinidine, quinine, Cholinesterase inhibitor, Parasympathomimetic
Hemoptysis (10%) ranolazine, rifabutin, rifampin, rilpivirine, ritonavir, Half-life: 52 minutes
Pulmonary embolism (5%) rivaroxaban, romidepsin, rosuvastatin, ruxolitinib, Clinically important, potentially hazardous
Pulmonary toxicity [2] saquinavir, sildenafil, simeprevir, simvastatin, interactions with: aminoglycosides,
solifenacin, St John’s wort, sunitinib, tacrolimus, antiarrhythmics, anticholinergics, chloroquine,
Endocrine/Metabolic
tadalafil, telithromycin, temazepam, temsirolimus, clindamycin, hydroxychloroquine, kanamycin,
Hypocalcemia (45%)
ticagrelor, tolterodine, tolvaptan, triazolam, lithium, local and general anesthetics, neomycin,
Hypokalemia (28%)
vardenafil, vemurafenib, vorapaxar non-depolarising muscle relaxants, polymixins,
Hypomagnesemia (83%) [8]
Pregnancy category: B propafenone, propranolol, streptomycin,
Hypophosphatemia (31%)
Important contra-indications noted in the succinylcholine
Weight loss (13%)
prescribing guidelines for: nursing mothers Pregnancy category: C (Anticholinesterase
Hematologic Note: Protease inhibitors cause dyslipidemia drugs may cause uterine irritability and induce
Anemia [2] which includes elevated triglycerides and premature labor when given intravenously to
Febrile neutropenia [2] cholesterol and redistribution of body fat centrally pregnant women near term)
Neutropenia [4] to produce the so-called ‘protease paunch’, Important contra-indications noted in the
Thrombocytopenia [3] breast enlargement, facial atrophy, and ‘buffalo prescribing guidelines for: nursing mothers;
Ocular hump’. pediatric patients
Conjunctivitis (7%) Note: Neostigmine bromide is given orally;
Local Skin neostigmine methylsulfate is given parenterally.
Infusion-related reactions (2%) [2] Rash (<10%) [4] Contra-indicated in patients with a previous
history of reaction to bromides, or those with
Other Gastrointestinal/Hepatic
peritonitis or mechanical obstruction of the
Adverse effects [2] Diarrhea [3]
intestinal or urinary tract.
Death [2] Hepatotoxicity [3]
Genitourinary
Skin
Urolithiasis [2]
NEDOCROMIL Hematologic
Cardiovascular
Lymphopenia [2]
See: www.drugeruptiondata.com/drug/id/966 Atrioventricular block [3]
Bradycardia [3]
Cardiac arrest [3]
NEOMYCIN Tachycardia [2]
NEFAZODONE Central Nervous System
Trade names: Maxitrol (Falcon), Neosporin
See: www.drugeruptiondata.com/drug/id/491 Anxiety [2]
(Monarch)
Sedation [2]
susceptible organisms Gastrointestinal/Hepatic
NELARABINE Class: Antibiotic, aminoglycoside Abdominal pain [3]
Diarrhea [2]
Half-life: 3 hours
See: www.drugeruptiondata.com/drug/id/1121 Clinically important, potentially hazardous Nausea [14]
interactions with: acarbose, aldesleukin, Vomiting [12]
aminoglycosides, atracurium, bacitracin, Respiratory
bumetanide, doxacurium, ethacrynic acid,
NELFINAVIR furosemide, methoxyflurane, neostigmine,
Bronchospasm [3]
pancuronium, penicillin V, polypeptide antibiotics,

Trade name: Viracept (ViiV)
rocuronium, sorafenib, succinylcholine,
Indications: HIV infection
teicoplanin, torsemide, vecuronium NEPAFENAC
Class: Antiretroviral, CYP3A4 inhibitor, HIV-1
protease inhibitor See: www.drugeruptiondata.com/drug/id/1090
pediatric patients
interactions with: abiraterone, afatinib,
Note: Aminoglycosides may cause neurotoxicity
alfuzosin, amiodarone, amprenavir, aripiprazole,
and/or nephrotoxicity.
artemether/lumefantrine, atorvastatin, avanafil,
NERATINIB See all our books at www.crcpress.com
Hematologic Skin
NERATINIB * Anemia [2] Angioedema [2]
Leukopenia [2] DRESS syndrome [12]
Trade name: Nerlynx (Puma) Neutropenia [3] Exanthems [6]
Indications: Early stage HER2-overexpressed/ Hypersensitivity [15]
amplified breast cancer, to follow adjuvant Lipodystrophy [2]
trastuzumab-based therapy
Class: Kinase inhibitor NESIRITIDE Rash (<48%) [31]
Half-life: 7–17 hours Toxic epidermal necrolysis [16]
Toxicity [3]
interactions with: aprepitant, boceprevir,
bosentan, carbamazepine, cimetidine, Mucosal
ciprofloxacin, clarithromycin, clotrimazole, NETUPITANT & Gingivitis (<3%)
Ulcerative stomatitis (4%)
cobicistat, conivaptan, crizotinib, cyclosporine,
dabigatran, dasabuvir/ombitasvir/paritaprevir/ PALONOSETRON Central Nervous System
ritonavir, digoxin, diltiazem, dronedarone, Fever [2]
efavirenz, enzalutamide, erythromycin, etravirine, Synonym: NEPA Paresthesias (2%)
fexofenadine, fluconazole, fluvoxamine, grapefruit Trade name: Akynzeo (Helsinn) Peripheral neuropathy [2]
juice, H2-receptor antagonists, idelalisib, imatinib, Indications: Acute and delayed nausea and
vomiting associated with cancer chemotherapy Neuromuscular/Skeletal
indinavir, itraconazole, ketoconazole, Myalgia/Myopathy (<10%)
lansoprazole, lopinavir, mitotane, modafinil, Class: Neurokinin 1 receptor antagonist
nefazodone, nelfinavir, ombitasvir/paritaprevir/ (netupitant), Serotonin type 3 receptor antagonist Gastrointestinal/Hepatic
ritonavir, phenytoin, posaconazole, rifampin, (palonosetron) Hepatic failure [2]
ritonavir, saquinavir, St John’s wort, strong or Half-life: 40 hours Hepatotoxicity [30]
moderate CYP3A4 inhibitors or inducers, Clinically important, potentially hazardous Endocrine/Metabolic
tipranavir, tofisopam, troleandomycin, verapamil, interactions with: rifampin Acidosis [2]
voriconazole Pregnancy category: C
Important contra-indications noted in the Other
prescribing guidelines for: nursing mothers; Adverse effects [7]
harm)
pediatric patients Death [3]
pediatric patients Skin
Erythema (3%) NIACIN
Skin Central Nervous System Synonyms: nicotinic acid; vitamin B3
Fissures (2%) Headache (9%) [7] Trade names: Advicor (Kos), Niacor (Upsher-
Rash (18%)
Neuromuscular/Skeletal Smith), Niaspan (Merck), Simcor (AbbVie), Slo-
Xerosis (6%) Niacin (Upsher-Smith)
Asthenia (fatigue) (4–8%)
Nails Indications: Hyperlipidemia
Nail disorder (8%) Class: Vitamin
Mucosal Dyspepsia (4%) [2] Half-life: 45 minutes
Epistaxis (nosebleed) (5%) Clinically important, potentially hazardous
Other interactions with: antihypertensives,
Stomatitis (14%)
Adverse effects [2] atorvastatin, bile acid sequestrants, insulin aspart,
Xerostomia (3%)
Hiccups [2] insulin degludec, insulin detemir, insulin glargine,
Cardiovascular insulin glulisine, pitavastatin, rosuvastatin,
Cardiotoxicity [2] selenium
Central Nervous System NEVIRAPINE Pregnancy category: C (Where niacin is co-
Anorexia [4] administered with a statin, refer to the pregnancy
Peripheral neuropathy [2] Trade name: Viramune (Boehringer Ingelheim) category for the statin)
Neuromuscular/Skeletal Indications: HIV infection Important contra-indications noted in the
Asthenia (fatigue) (27%) [4] Class: Antiretroviral, CYP3A4 inducer, Non- prescribing guidelines for: nursing mothers;
Muscle spasm (11%) nucleoside reverse transcriptase inhibitor pediatric patients
Half-life: 45 hours Note: Contra-indicated in patients with active
Gastrointestinal/Hepatic Clinically important, potentially hazardous liver or peptic ulcer disease, or arterial bleeding.
Abdominal distension (5%) interactions with: amiodarone, amprenavir, Simcor is niacin and simvastatin.
Abdominal pain (36%) atazanavir, carbamazepine, caspofungin,
Diarrhea (95%) [13] clarithromycin, clonazepam, cyclosporine,
Dyspepsia (10%) Skin
diltiazem, disopyramide, efavirenz, ethosuximide, Acanthosis nigricans (8%) [14]
Hepatotoxicity (<2%) etravirine, fentanyl, fluconazole, fosamprenavir,
Nausea (43%) [8] Exanthems (<3%)
indinavir, itraconazole, ketoconazole, Pruritus (<5%) [9]
Vomiting (26%) [5] levonorgestrel, lidocaine, lopinavir, midazolam, Rash [5]
Endocrine/Metabolic nifedipine, rifampin, rilpivirine, simeprevir, St
ALT increased (9%) John’s wort, verapamil Cardiovascular
Appetite decreased (12%) Pregnancy category: B Flushing (<30%) [31]
AST increased (7%) Important contra-indications noted in the Central Nervous System
Dehydration (4%) prescribing guidelines for: nursing mothers Paresthesias (<10%) [2]
Weight loss (5%) Warning: LIFE-THREATENING (INCLUDING Neuromuscular/Skeletal
Genitourinary FATAL) HEPATOTOXICITY and SKIN Myalgia/Myopathy [5]
Urinary tract infection (5%) REACTIONS
Hepatotoxicity [3]
Litt’s Drug Eruption & Reaction Manual NIFEDIPINE
Endocrine/Metabolic nevirapine, oxcarbazepine, parenteral

Hyperglycemia [2] NICOTINE magnesium, phenytoin, posaconazole,
Ocular propranolol, rifampin, ritonavir, St John’s wort,
Trade names: Habitrol Patch (Novartis), tacrolimus, vardenafil, vincristine
Maculopathy [3] Nicoderm (GSK), Nicorette (GSK), Nicotrol Pregnancy category: C
(Pfizer) Important contra-indications noted in the
Indications: Aid to smoking cessation prescribing guidelines for: the elderly; nursing
NIACINAMIDE Class: Alkaloid mothers; pediatric patients
Half-life: varies with the delivery system Note: Tenif is atenolol and nifedipine.
Synonyms: nicotinamide; vitamin B3 Clinically important, potentially hazardous
Indications: Prophylaxis and treatment of interactions with: adenosine, bendamustine,
pellagra heparin, horsetail Skin
Class: Vitamin Pregnancy category: D AGEP [3]
Half-life: 45 minutes Important contra-indications noted in the Angioedema [2]
Clinically important, potentially hazardous prescribing guidelines for: nursing mothers; Bullous dermatitis [2]
interactions with: atorvastatin, primidone, pediatric patients Dermatitis (<2%)
rosuvastatin Note: Smoking cessation therapy has various Diaphoresis (<2%) [2]
Pregnancy category: A (the pregnancy category delivery systems. These include: transdermal Edema [3]
will be C if used in doses above the RDA) patches, chewing gum, nasal spray, inhaler, and Erysipelas [2]
oral forms. Erythema [2]
Skin Erythema nodosum [2]
Pruritus (<5%) [2] Skin Exanthems [9]
Central Nervous System Acneform eruption (3%) Exfoliative dermatitis [5]
Paresthesias (<10%) Diaphoresis (<3%) Fixed eruption [2]
Erythema (>10%) Lichenoid eruption [3]
Hematologic Pigmentation [3] Lupus erythematosus [3]
Thrombocytopenia [2] Pruritus (>10%) Peripheral edema [12]
Mucosal Photosensitivity [5]
Sialorrhea (>10%) Pruritus (<2%) [3]
NICARDIPINE Stomatitis (>10%) Purpura (<2%) [3]
Xerostomia (<3%) Rash (<3%) [2]
Trade name: Cardene (Roche) Stevens-Johnson syndrome [3]
Indications: Angina, hypertension Central Nervous System
Headache (18–26%) Telangiectasia [2]
Class: Calcium channel blocker Toxic epidermal necrolysis [2]
Half-life: 24 hours Neuromuscular/Skeletal Urticaria [7]
Clinically important, potentially hazardous Arthralgia (5%) Vasculitis [4]
interactions with: amprenavir, atazanavir, Back pain (6%)
boceprevir, cobicistat/elvitegravir/emtricitabine/ Myalgia/Myopathy (<10%)
Hair
tenofovir alafenamide, cobicistat/elvitegravir/
Alopecia [4]
emtricitabine/tenofovir disoproxil, delavirdine, Dyspepsia (18%)
Mucosal
epirubicin, imatinib, indinavir, lopinavir, Flatulence (4%) Gingival hyperplasia/hypertrophy (610%)
posaconazole, propranolol, telaprevir Pancreatitis [2] [75]
Pregnancy category: C Throat irritation/pain (66%) Xerostomia (<3%)
prescribing guidelines for: the elderly; pediatric Respiratory
Cough (32%) [2] Erythromelalgia [4]
patients Flushing (325%) [9]
Rhinitis (23%)
Hypotension [9]
Skin Other Pulmonary edema [3]
Peripheral edema (7%) [2] Death [2] Tachycardia [4]
Rash [3] Hiccups [2]
Urticaria [3] Chills (2%)
Mucosal Headache (19%) [7]
Gingival hyperplasia/hypertrophy [2] NIFEDIPINE Paresthesias (<3%)
Cardiovascular Tremor (28%)
Trade names: Adalat (Bayer), Coracten (UCB), Vertigo (dizziness) [5]
Erythromelalgia [2] Procardia (Pfizer), Tenif (AstraZeneca), Tensipine
Flushing (6%) [2] MR (Genus), Valni XL (Winthrop)
Pulmonary edema [5] Indications: Angina, hypertension Asthenia (fatigue) (4%)
Endocrine/Metabolic Class: Calcium channel blocker Gastrointestinal/Hepatic
Gynecomastia [2] Half-life: 2–5 hours (immediate release products) Hepatotoxicity [3]
Other Clinically important, potentially hazardous Nausea (2%) [2]
Adverse effects [2] interactions with: acebutolol, amprenavir, Endocrine/Metabolic
Side effects [2] atazanavir, beta blockers, boceprevir, Gynecomastia [6]
carbamazepine, cobicistat/elvitegravir/
emtricitabine/tenofovir alafenamide, cobicistat/ Other
elvitegravir/emtricitabine/tenofovir disoproxil, Adverse effects [4]
NICORANDIL cyclosporine, delavirdine, digoxin, diltiazem, Side effects [3]
dronedarone, efavirenz, epirubicin, fentanyl,
See: www.drugeruptiondata.com/drug/id/1081 fluoxetine, grapefruit juice, imatinib, indinavir,
insulin, lopinavir, micafungin, mizolastine,
NILOTINIB Over 100 updates per week on www.drugeruptiondata.com
Central Nervous System Periorbital edema (<10%)

NILOTINIB Anorexia (<10%) Xerophthalmia (<10%)
Depression (<10%) [2] Other
Trade name: Tasigna (Novartis) Fever (<10%) [2]
Indications: Chronic myelogenous leukemia Adverse effects [3]
Headache (~10%) [13] Death [3]
Class: Antineoplastic, Epidermal growth factor Hypoesthesia (<10%)
receptor (EGFR) inhibitor, Tyrosine kinase Side effects [3]
Insomnia (<10%)
inhibitor Pain [2]
Half-life: 17 hours Paresthesias (<10%)
Clinically important, potentially hazardous Stroke [2] NILUTAMIDE
interactions with: amiodarone, amitriptyline, Vertigo (dizziness) (<10%)
amoxapine, arsenic, astemizole, bepridil, See: www.drugeruptiondata.com/drug/id/1212
carbamazepine, chloroquine, cisapride, Neuromuscular/Skeletal
citalopram, clarithromycin, clozapine, conivaptan, Arthralgia (<10%) [3]
Asthenia (fatigue) (<10%) [9]
darunavir, dasatinib, degarelix, delavirdine,
digoxin, dihydroergotamine, disopyramide, Bone or joint pain (<10%) NIMESULIDE
dolasetron, efavirenz, ergotamine, grapefruit Muscle spasm [3]
Myalgia/Myopathy (<10%) [5] See: www.drugeruptiondata.com/drug/id/1228
juice, halofantrine, haloperidol, indinavir,
itraconazole, ketoconazole, lapatinib, Neck pain (<10%)
levofloxacin, lopinavir, methadone, midazolam, Gastrointestinal/Hepatic
moxifloxacin, oxcarbazepine, pazopanib, Abdominal distension (<10%) NIMODIPINE
phenobarbital, phenytoin, pimozide, Abdominal pain (<10%) [2]
procainamide, quinidine, rifampin, rifapentine, Constipation (~10%) [2] See: www.drugeruptiondata.com/drug/id/500
ritonavir, sotalol, St John’s wort, telavancin, Diarrhea (~10%) [4]
telithromycin, terfenadine, voriconazole, Dyspepsia (<10%)
vorinostat, ziprasidone Flatulence (<10%) NINTEDANIB
Pregnancy category: D Hepatotoxicity [5]
Important contra-indications noted in the Nausea (~10%) [8] Trade name: Ofev (Boehringer Ingelheim)
prescribing guidelines for: nursing mothers; Pancreatitis (<10%) [4] Indications: Idiopathic pulmonary fibrosis
pediatric patients Vomiting (~10%) Class: Tyrosine kinase inhibitor
Note: Contra-indicated in patients with Respiratory Half-life: 9.5 hours
hypokalemia, hypomagnesemia, or long QT Clinically important, potentially hazardous
Cough (<10%)
syndrome. interactions with: anticoagulants,
Dysphonia (<10%)
Warning: QT PROLONGATION AND carbamazepine, erythromycin, phenytoin, St
Dyspnea (<10%)
SUDDEN DEATHS John’s wort
Nasopharyngitis [2]
Pleural effusion [2]
Pulmonary hypertension [2]
Acneform eruption (<10%) prescribing guidelines for: nursing mothers;
Endocrine/Metabolic pediatric patients
Dermatitis (<10%) ALT increased (4%) [3]
Eczema (<10%) AST increased (<3%) [2]
Edema [3] Diabetes mellitus (<10%) Skin
Erythema (<10%) [2] Hyperamylasemia [2] Hand–foot syndrome [2]
Exanthems [2] Hyperbilirubinemia [6] Rash [4]
Folliculitis (<10%) Hypercalcemia (<10%) Hair
Hematoma (<10%) Hypercholesterolemia (<10%) Alopecia [2]
Hyperhidrosis (<10%) Hyperglycemia (6–12%) [5]
Peripheral edema (<10%) Mucosal
Hyperkalemia (2–6%) Epistaxis (nosebleed) [2]
Pruritus (<10%) [13] Hyperlipidemia (<10%)
Rash (<10%) [16] Hypocalcemia (<10%) Cardiovascular
Sweet’s syndrome [3] Hypokalemia (<10%) [2] Cardiotoxicity [2]
Toxicity [7] Hypomagnesemia (<10%) Hypertension (5%) [7]
Urticaria (<10%) Hyponatremia (<10%) Myocardial infarction (2%)
Xerosis [2] Hypophosphatemia (5–17%) [3] Central Nervous System
Hair Hypothyroidism [2] Anorexia [6]
Alopecia (<10%) [4] Weight gain (<10%) Headache (8%)
Cardiovascular Weight loss (<10%) Peripheral neuropathy [2]
Angina (<10%) Genitourinary Neuromuscular/Skeletal
Arrhythmias (<10%) [2] Pollakiuria (<10%) Asthenia (fatigue) [15]
Arterial occlusion [5] Hematologic Gastrointestinal/Hepatic
Atrial fibrillation (<10%) Anemia (4–27%) [8] Abdominal pain (15%) [6]
Atrioventricular block (<10%) Febrile neutropenia (<10%) Diarrhea (62%) [28]
Bradycardia (<10%) Hyperlipasemia [3] Gastrointestinal disorder [4]
Cardiotoxicity [4] Lymphopenia (<10%) Hepatotoxicity (14%) [10]
Chest pain (<10%) Neutropenia (12–42%) [8] Nausea (24%) [21]
Extrasystoles (<10%) Pancytopenia (<10%) Vomiting (12%) [18]
Flushing (<10%) Thrombocytopenia (10–42%) [9]
Hypertension (<10%) Respiratory
Myocardial infarction [2] Ocular Bronchitis [3]
Palpitation (<10%) Conjunctivitis (<10%) Cough [3]
QT prolongation (<10%) [8] Ocular hemorrhage (<10%) Dyspnea [4]
Litt’s Drug Eruption & Reaction Manual NITROFURAZONE
Nasopharyngitis [3] Dyspepsia (18%)

Pneumonia [3] Nausea (74%) NITISINONE
Upper respiratory tract infection [2] Vomiting (34%)
Endocrine/Metabolic Respiratory
ALT increased [11] Bronchitis (<10%)
Appetite decreased (11%) [6] Dyspnea (20%)
AST increased [9] Nasopharyngitis (23%) NITRAZEPAM
Weight loss (10%) [2] Endocrine/Metabolic See: www.drugeruptiondata.com/drug/id/1262
Hematologic ALT increased (10%)
Anemia [3] Appetite decreased (25%)
Bleeding (10%) [3] AST increased (10%)
Leukopenia [2] Creatine phosphokinase increased (<10%) NITROFURANTOIN
Neutropenia [4] GGT increased (<10%)
Thrombocytopenia [2] Hypokalemia (<10%) Trade names: Furadantin (First Horizon),
Serum creatinine increased (<10%) Macrobid (Procter & Gamble), Macrodantin
Other (Procter & Gamble)
Adverse effects [5] Weight loss (<10%)
Indications: Various urinary tract infections
Death [3] Genitourinary caused by susceptible organisms
Urinary tract infection (13%) Class: Antibiotic
Hematologic Half-life: 1–2 minutes
NIRAPARIB * Anemia (50%) [2] Clinically important, potentially hazardous
Leukopenia (17%) interactions with: norfloxacin
Trade name: Zejula (Tesaro) Neutropenia (30%) [2] Pregnancy category: B
Indications: Maintenance treatment of adult Thrombocytopenia (61%) [2] Important contra-indications noted in the
patients with recurrent epithelial ovarian, fallopian Ocular prescribing guidelines for: nursing mothers;
tube, or primary peritoneal cancer who are in a Conjunctivitis (<10%) pediatric patients
complete or partial response to platinum-based
chemotherapy Skin
Class: Poly (ADP-ribose) polymerase (PARP)
inhibitor NISOLDIPINE Anaphylactoid reactions/Anaphylaxis [2]
Angioedema [4]
Half-life: 36 hours Dermatitis [3]
Clinically important, potentially hazardous Trade name: Sular (First Horizon)
Indications: Hypertension DRESS syndrome [4]
interactions with: none known Eczema [2]
Pregnancy category: N/A (Can cause fetal Class: Calcium channel blocker
Half-life: 712 hours Erythema multiforme [3]
harm) Exanthems (<5%) [9]
interactions with: amprenavir, conivaptan, Exfoliative dermatitis [3]
prescribing guidelines for: nursing mothers; Lupus erythematosus [8]
pediatric patients cyclosporine, darunavir, delavirdine, efavirenz,
epirubicin, grapefruit juice, imatinib, indinavir, Purpura [2]
itraconazole, ketoconazole, oxcarbazepine, Rash [2]
Skin propranolol, telaprevir, telithromycin, Stevens-Johnson syndrome [2]
Peripheral edema (<10%) voriconazole Toxic epidermal necrolysis [5]
Rash (21%) Pregnancy category: C Urticaria [8]
Mucosal Hair
Epistaxis (nosebleed) (<10%) Skin Alopecia [5]
Mucositis (20%) Peripheral edema (22%) [6] Central Nervous System
Stomatitis (20%) Rash (2%) Neurotoxicity [2]
Xerostomia (10%) Paresthesias (<10%)
Cardiovascular Headache [4] Gastrointestinal/Hepatic
Hypertension (20%) Hepatitis [2]
Palpitation (10%) Endocrine/Metabolic
Gynecomastia [2] Hepatotoxicity [14]
Tachycardia (<10%)
Respiratory
Central Nervous System Pneumonitis [3]
Anxiety (11%)
Depression (<10%) NITAZOXANIDE Pulmonary toxicity [8]
Dysgeusia (taste perversion) (10%) Other
Headache (26%) Trade name: Alinia (Romark) Adverse effects [3]
Insomnia (27%) Indications: Diarrhea caused by Cryptosporidium Death [3]
Vertigo (dizziness) (18%) parvum or Giardia lamblia (in children)
Class: Antiprotozoal
Arthralgia (13%)
Half-life: N/A
NITROFURAZONE
Asthenia (fatigue) (57%) interactions with: none known
Back pain (18%) See: www.drugeruptiondata.com/drug/id/1022
Abdominal distension (33%) Headache [2]
Constipation (40%) Gastrointestinal/Hepatic
Diarrhea (20%) Abdominal pain [3]
Diarrhea [2]
NITROGLYCERIN See all our books at www.crcpress.com
Edema (17%) [2] Hyponatremia (25–38%)

NITROGLYCERIN Erythema [3] Hypophosphatemia [2]
Erythema multiforme (<10%) Hypophysitis [10]
Synonyms: glyceryl trinitrate; nitroglycerol; NTG Exanthems [2] Hypothyroidism [16]
Trade names: Minitran (3M), Nitrodur Exfoliative dermatitis (<10%) Serum creatinine increased (22%) [2]
(Schering) (Key), Nitrolingual (First Horizon), Hypersensitivity [2] Thyroid dysfunction [7]
Nitrostat (Pfizer) Lichenoid eruption [2] Thyroiditis [7]
Indications: Acute angina Pruritus (11–19%) [25] Weight loss (13%)
Class: Nitrate, Vasodilator Psoriasis (<10%) [3]
Half-life: 14 minutes Renal
Rash (16–21%) [33] Nephrotoxicity [10]
Clinically important, potentially hazardous Sarcoidosis [6]
interactions with: acetylcysteine, alteplase, Renal failure [4]
heparin, sildenafil, tadalafil, vardenafil Toxicity [4] Hematologic
Pregnancy category: C Vitiligo (<10%) [13] Anemia (28%) [4]
Important contra-indications noted in the Hemolytic anemia [4]
prescribing guidelines for: nursing mothers; Mucosal Hyperlipasemia [4]
pediatric patients Stomatitis (<10%) Lymphopenia (47%) [3]
Xerostomia [2] Neutropenia [6]
Skin Cardiovascular Thrombocytopenia (14%) [5]
Dermatitis (to topical systems) [25] Chest pain (13%) Ocular
Eczema [2] Myocarditis [5] Iridocyclitis (<10%)
Erythema (to transdermal delivery system) Ventricular arrhythmia (<10%) Uveitis [3]
[2] Central Nervous System Local
Exfoliative dermatitis (<10%) Encephalopathy [6] Infusion-related reactions (<10%) [5]
Purpura [2] Fever (17%) [8]
Rash (<10%) Neurotoxicity [4] Other
Urticaria [2] Pain (10%) Adverse effects [25]
Peripheral neuropathy (<10%) Death [11]
Cardiovascular Side effects [2]
Bradycardia [2] Vertigo (dizziness) (<10%)
Flushing (>10%) Neuromuscular/Skeletal
Hypotension [4] Arthralgia (13%) [7]
Central Nervous System Asthenia (fatigue) (19–50%) [26] NIZATIDINE
Headache [14] Bone or joint pain (36%)
Migraine [2]
Polymyositis [2]
NITROPRUSSIDE
Synovial effusions [2] NORFLOXACIN
Abdominal pain (16%) Trade names: Chibroxin (Merck), Noroxin
See: www.drugeruptiondata.com/drug/id/1214 (Merck)
Colitis [20]
Constipation (24%) Indications: Various urinary tract infections
Diarrhea (18%) [26] caused by susceptible organisms, conjunctivitis
NIVOLUMAB Hepatitis [9] Class: Antibiotic, fluoroquinolone, CYP3A4
Hepatotoxicity [12] inhibitor
Trade name: Opdivo (Bristol-Myers Squibb) Nausea (29%) [13] Half-life: 3–4 hours
Indications: Metastatic squamous non-small cell Pancreatitis [4] Clinically important, potentially hazardous
lung cancer with progression on or after Vomiting (19%) [2] interactions with: aminophylline, amiodarone,
platinum-based chemotherapy, unresectable or antacids, arsenic, artemether/lumefantrine,
metastatic melanoma and disease progression Respiratory bepridil, bretylium, caffeine, ciprofibrate,
following ipilimumab and, if BRAF V600 mutation Bronchitis (<10%) clozapine, cyclosporine, dairy products,
positive, a BRAF inhibitor, advanced renal cell Cough (17–32%) [2] didanosine, disopyramide, erythromycin,
carcinoma with prior anti-angiogenic therapy, Dyspnea (38%) [3] glyburide, lanthanum, mycophenolate,
Hodgkin lymphoma that has relapsed or Pneumonia (10%) [4] nitrofurantoin, NSAIDs, oral iron, oral typhoid
progressed after autologous hematopoietic stem Pneumonitis [27] vaccine, oxtriphylline, phenothiazines,
cell transplantation and post-transplantation Pulmonary toxicity [2] probenecid, procainamide, quinidine, ropinirole,
brentuximab vedotin Upper respiratory tract infection (11%) sotalol, strontium ranelate, sucralfate, tacrine,
Class: Monoclonal antibody, Programmed death Endocrine/Metabolic tamoxifen, tizanidine, tricyclic antidepressants,
receptor-1 (PD-1) inhibitor Adrenal insufficiency [3] warfarin, zinc, zolmitriptan
Half-life: 27 days ALP increased (14–22%) Pregnancy category: C
Clinically important, potentially hazardous ALT increased (12–16%) [5] Important contra-indications noted in the
interactions with: none known Appetite decreased (35%) [9] prescribing guidelines for: the elderly; nursing
Pregnancy category: N/A (Can cause fetal AST increased (16–28%) [4] mothers; pediatric patients
harm) Diabetes mellitus [10] Note: Fluoroquinolones are associated with an
Important contra-indications noted in the Hyperamylasemia [2] increased risk of tendinitis and tendon rupture in
prescribing guidelines for: nursing mothers; Hypercalcemia (20%) all ages. This risk is further increased in older
pediatric patients Hyperkalemia (15–18%) patients usually over 60 years of age, in patients
Hyperthyroidism [9] taking corticosteroid drugs, and in patients with
Skin Hypocalcemia (18%) kidney, heart or lung transplants.
Bullous pemphigoid [5] Hypokalemia (20%) Fluoroquinolones may exacerbate muscle
Dermatitis [3] Hypomagnesemia (20%) weakness in persons with myasthenia gravis.
Litt’s Drug Eruption & Reaction Manual NYSTATIN
Skin
Pregnancy category: D Central Nervous System
Important contra-indications noted in the Headache (50%)
Exanthems [2]
prescribing guidelines for: pediatric patients Neuromuscular/Skeletal
Fixed eruption [3]
Warning: SUICIDALITY AND Back pain (41%)
Phototoxicity [4]
ANTIDEPRESSANT DRUGS Scoliosis (5%)
Nails Gastrointestinal/Hepatic
Skin Constipation (30%)
Photo-onycholysis [2]
Diaphoresis (<10%)
Neuromuscular/Skeletal Photosensitivity [2] Respiratory
Rhabdomyolysis [2] Bronchitis (>5%)
Mucosal Upper respiratory tract infection (39%)
Tendinopathy/Tendon rupture [4]
Xerostomia (>10%) [9]
Other Otic
Central Nervous System Ear infection (5%)
Adverse effects [2]
Dysgeusia (taste perversion) (>10%)
Parkinsonism (<10%)
NORTRIPTYLINE Other
NYSTATIN
Adverse effects [2] Trade names: Mycology-II (Bristol-Myers
Trade names: Aventyl (Ranbaxy), Pamelor
(Mallinckrodt) Squibb), Mycostatin (Bristol-Myers Squibb)
Indications: Depression Indications: Candidiasis
Class: Antidepressant, tricyclic NUSINERSEN * Class: Antifungal
Half-life: 2831 hours Half-life: ~2–3 hours
Clinically important, potentially hazardous Trade name: Spinraza (Biogen) Clinically important, potentially hazardous
interactions with: amprenavir, arbutamine, Indications: Spinal muscular atrophy interactions with: none known
clonidine, cobicistat/elvitegravir/emtricitabine/ Class: Survival motor neuron-2 (SMN2)-directed Pregnancy category: C
tenofovir alafenamide, cobicistat/elvitegravir/ antisense oligonucleotide Important contra-indications noted in the
emtricitabine/tenofovir disoproxil, epinephrine, Half-life: 63–87 days (in plasma) prescribing guidelines for: nursing mothers
fluoxetine, formoterol, guanethidine, Clinically important, potentially hazardous
isocarboxazid, linezolid, MAO inhibitors, interactions with: none known Skin
phenelzine, quinolones, sparfloxacin, Pregnancy category: N/A (No data available) AGEP [5]
tranylcypromine Important contra-indications noted in the Dermatitis [12]
prescribing guidelines for: nursing mothers Eczema [2]
Fixed eruption [2]
OBETICHOLIC ACID Over 100 updates per week on www.drugeruptiondata.com
Leukoencephalopathy [2] Pregnancy category: C

OBETICHOLIC ACID Gastrointestinal/Hepatic Important contra-indications noted in the
Nausea [3] prescribing guidelines for: nursing mothers;
Trade name: Ocaliva (Intercept) pediatric patients
Indications: Primary biliary cholangitis Respiratory
Class: Farnesoid X receptor (FXR) agonist Cough (10%) [2]
Half-life: N/A Ocular
Endocrine/Metabolic Cataract (2–4%)
Clinically important, potentially hazardous ALP increased (16%)
interactions with: aminophylline, tizanidine, Conjunctival hemorrhage (5–20%)
AST increased (25%) Conjunctival hyperemia (2–4%)
warfarin Hyperkalemia (31%)
Pregnancy category: N/A (Insufficient evidence Dyschromatopsia (2%)
Hypoalbuminemia (22%) Intraocular inflammation (7%)
to inform drug-associated risk) Hypocalcemia (32%)
Important contra-indications noted in the Intraocular pressure increased (4%)
Hypokalemia (13%) Iritis (2–4%)
pediatric patients Hematologic Macular edema (2–4%)
Note: Contra-indicated in patients with complete Anemia (12%) [4] Macular hole (5–20%)
biliary obstruction. Leukopenia (7%) Ocular adverse effects [2]
Neutropenia (40%) [12] Ocular hemorrhage (2%)
Thrombocytopenia (15%) [7] Ocular pain (5–20%) [2]
Skin Photophobia (2–4%)
Eczema (3–6%) Local
Infusion-related reactions (69%) [15] Photopsia (5–20%) [4]
Peripheral edema (3–7%) Reduced visual acuity (5–20%) [2]
Pruritus (56–70%) [4] Other Retinal edema (5–20%)
Rash (7–10%) Infection (38%) [8] Vision blurred (5–20%)
Urticaria (<10%) Vision impaired (5–20%)
Mucosal Vision loss [3]
Oropharyngeal pain (7–8%) OCRELIZUMAB * Vitreous detachment (2–4%)
Cardiovascular Vitreous floaters (5–20%) [4]
Palpitation (3–7%) Trade name: Ocrevus (Genentech) Xerophthalmia (2–4%)
Indications: Relapsing or primary progressive
Central Nervous System forms of multiple sclerosis
Fever (<7%)
Syncope (<7%)
Class: CD20-directed cytolytic monoclonal
antibody, Monoclonal antibody
OCTREOTIDE
Vertigo (dizziness) (7%) Half-life: 26 days Trade name: Sandostatin (Novartis)
Neuromuscular/Skeletal Clinically important, potentially hazardous Indications: Diarrhea, sulfonylurea poisoning
Arthralgia (6–10%) interactions with: none known Class: Somatostatin analog
Asthenia (fatigue) (19–25%) Pregnancy category: N/A (May cause fetal Half-life: 1.5 hours
Gastrointestinal/Hepatic toxicity based on findings in animal studies) Clinically important, potentially hazardous
Abdominal pain (10–19%) Important contra-indications noted in the interactions with: bromocriptine, insulin aspart,
Constipation (7%) prescribing guidelines for: nursing mothers; insulin degludec, metformin
pediatric patients Pregnancy category: B
Endocrine/Metabolic Note: Contra-indicated in active hepatitis B virus Important contra-indications noted in the
Thyroid dysfunction (4–6%) infection. prescribing guidelines for: the elderly; nursing
OBINUTUZUMAB Depression (8%) Skin
Neuromuscular/Skeletal Cellulitis (<4%)
Trade name: Gazyva (Genentech)
Back pain (6%) Diaphoresis (5–15%)
Indications: Chronic lymphocytic leukemia (in
Pain in extremities (5%) Edema (<10%)
combination with chlorambucil), follicular
Petechiae (<4%)
lymphoma (firstly with bendamustine then as Respiratory
Pruritus (18%)
monotherapy) Upper respiratory tract infection (40–49%)
Purpura (<4%)
Class: CD20-directed cytolytic monoclonal [2]
Rash (5–15%)
antibody, Monoclonal antibody Hematologic Raynaud’s phenomenon (<4%)
Half-life: 28 days Neutropenia (13%) Urticaria (<4%)
interactions with: live vaccines Local Hair
Pregnancy category: N/A (Insufficient evidence Infusion-related reactions (34–40%) [6] Alopecia (~13%) [4]
to inform drug-associated risk) Other Cardiovascular
Important contra-indications noted in the Infection (58%) [3] Arrhythmias (3–9%)
prescribing guidelines for: nursing mothers; Bradycardia (19–25%) [4]
pediatric patients Chest pain (20%)
Warning: HEPATITIS B VIRUS REACTIVATION
AND PROGRESSIVE MULTIFOCAL
OCRIPLASMIN Flushing (<4%)
Hypertension (13%) [3]
LEUKOENCEPHALOPATHY Trade name: Jetrea (ThromboGenics) QT prolongation [2]
Indications: Symptomatic vitreomacular Thrombophlebitis (<4%)
Skin adhesion Central Nervous System
Tumor lysis syndrome [5] Class: Enzyme Anorexia (4–6%)
Central Nervous System Half-life: N/A Headache [3]
Fever (10%) [4] Clinically important, potentially hazardous Pain (4–6%)
Headache [2] interactions with: none known Rigors (5–15%)
Litt’s Drug Eruption & Reaction Manual OFLOXACIN
Vertigo (dizziness) [2] Central Nervous System kidney, heart or lung transplants.
Neuromuscular/Skeletal Chills (8%) Fluoroquinolones may exacerbate muscle
Arthralgia (5–15%) Fever (20%) [2] weakness in persons with myasthenia gravis.
Asthenia (fatigue) [4] Headache (6%) Warning: SERIOUS ADVERSE REACTIONS
Myalgia/Myopathy (5–15%) [2] Insomnia (7%) INCLUDING TENDINITIS, TENDON
Peripheral neuropathy [2] RUPTURE, PERIPHERAL NEUROPATHY,
Gastrointestinal/Hepatic CENTRIAL NERVOUS SYSTEM EFFECTS and
Abdominal pain (5–61%) [4] Neuromuscular/Skeletal
Asthenia (fatigue) (15%) [4] EXACERBATION OF MYASTHENIA GRAVIS
Diarrhea (34–58%) [4]
Flatulence (38%) Back pain (8%)
Hepatotoxicity [3] Gastrointestinal/Hepatic Skin
Loose stools [2] Diarrhea (18%) [2] Anaphylactoid reactions/Anaphylaxis [4]
Nausea (5–61%) [6] Nausea (11%) [3] Angioedema [3]
Pancreatitis [2] Exanthems [3]
Respiratory Fixed eruption [4]
Vomiting (4–21%) Bronchitis (11%) Hypersensitivity [2]
Respiratory Cough (19%) Photosensitivity [8]
Cough (5–15%) Dyspnea (14%) Phototoxicity [3]
Pharyngitis (5–15%) Nasopharyngitis (8%) Pruritus (<3%) [5]
Rhinitis (5–15%) Pneumonia (23%) Pruritus ani et vulvae (<3%)
Sinusitis (5–15%) Pulmonary toxicity [3] Rash (<10%) [5]
Endocrine/Metabolic Upper respiratory tract infection (11%) Stevens-Johnson syndrome [4]
Galactorrhea (<4%) Hematologic Toxic epidermal necrolysis [3]
Gynecomastia (<4%) Anemia (16%) [4] Urticaria [3]
Hyperglycemia [6] Hemolysis [2] Vasculitis [4]
Hypothyroidism (12%) Hemolytic anemia [2] Nails
Genitourinary Leukopenia [2] Photo-onycholysis [2]
Vaginitis (<4%) Lymphopenia [2]
Neutropenia (>10%) [11] Mucosal
Hematologic Sepsis (8%) Oral mucosal eruption [3]
Anemia (15%) Thrombocytopenia [5] Xerostomia (<3%)
Neutropenia [2] Cardiovascular
Thrombocytopenia [3] Local
Infusion-related reactions [10] QT prolongation [3]
Otic Infusion-site reactions [2] Central Nervous System
Ear pain (5–15%) Dysgeusia (taste perversion) (<3%) [2]
Other
Local Adverse effects [2] Hallucinations [2]
Injection-site granuloma [2] Infection (70%) [10] Headache [3]
Injection-site pain (8%) [2] Insomnia [2]
Peripheral neuropathy [2]
Psychosis [2]
OFATUMUMAB OFLOXACIN Seizures [2]
Trade names: Floxin (Ortho-McNeil), Ocuflox
Trade name: Arzerra (Novartis) (Allergan), Taravid (Sanofi-Aventis) Neuromuscular/Skeletal
Indications: Chronic lymphocytic leukemia Indications: Various infections caused by Arthralgia [2]
Class: CD20-directed cytolytic monoclonal susceptible organisms Arthropathy [2]
antibody, Monoclonal antibody Class: Antibiotic, fluoroquinolone Asthenia (fatigue) [2]
Half-life: 14 days Half-life: 48 hours Myalgia/Myopathy [2]
Clinically important, potentially hazardous Clinically important, potentially hazardous Rhabdomyolysis [2]
interactions with: live vaccines interactions with: aminophylline, amiodarone, Tendinopathy/Tendon rupture [7]
Pregnancy category: N/A (May cause fetal B- antacids, arsenic, artemether/lumefantrine, BCG Gastrointestinal/Hepatic
cell depletion) vaccine, bendamustine, bepridil, bretylium, Abdominal pain [3]
Important contra-indications noted in the calcium salts, clozapine, corticosteroids, Diarrhea [2]
prescribing guidelines for: nursing mothers; cyclosporine, CYP1A2 substrates, didanosine, Nausea [4]
pediatric patients disopyramide, erythromycin, insulin, lanthanum, Vomiting [2]
Warning: HEPATITIS B VIRUS REACTIVATION magnesiuim salts, mycophenolate, NSAIDs, oral
AND PROGRESSIVE MULTIFOCAL Genitourinary
iron, oral typhoid vaccine, oxtriphylline, Vaginitis (<10%)
LEUKOENCEPHALOPATHY phenothiazines, probenecid, procainamide,
quinapril, quinidine, sevelamer, sotalol, St John’s Local
Skin wort, strontium ranelate, sucralfate, Injection-site pain (<10%)
Herpes (6%) sulfonylureas, tricyclic antidepressants, vitamin K Other
Hyperhidrosis (5%) antagonists, warfarin, zinc, zolmitriptan Adverse effects [10]
Peripheral edema (9%) Pregnancy category: C Death [2]
Rash (14%) [2] Important contra-indications noted in the Side effects [2]
Toxicity [3] prescribing guidelines for: the elderly; nursing
Urticaria (8%) mothers; pediatric patients
Cardiovascular Note: Fluoroquinolones are associated with an
Angina [2] increased risk of tendinitis and tendon rupture in
Hypertension (5%) all ages. This risk is further increased in older
Hypotension (5%) patients usually over 60 years of age, in patients
Tachycardia (5%) taking corticosteroid drugs, and in patients with
OLANZAPINE See all our books at www.crcpress.com
Sedation [17]
OLANZAPINE Seizures [8] OLAPARIB
Trade names: Symbyax (Lilly), Zyprexa (Lilly), Somnolence (drowsiness) (20–39%) [11] Trade name: Lynparza (AstraZeneca)
Zyprexa Relprevv (Lilly) Suicidal ideation [2] Indications: BRCA-mutated ovarian cancer
Indications: Schizophrenia, bipolar I disorder Tardive dyskinesia [5] Class: Poly (ADP-ribose) polymerase (PARP)
Class: Antipsychotic, Muscarinic antagonist Tremor (<10%) [5] inhibitor
Half-life: 2154 hours Twitching (2%) Half-life: 7–17 hours
Clinically important, potentially hazardous Vertigo (dizziness) [5] Clinically important, potentially hazardous
interactions with: alcohol, antihypertensive interactions with: amprenavir, aprepitant,
agents, carbamazepine, ciprofloxacin, CNS acting Neuromuscular/Skeletal atazanavir, boceprevir, bosentan, carbamazepine,
drugs, diazepam, dopamine agonists, eszopiclone, Asthenia (fatigue) (8–20%) [4] ciprofloxacin, clarithromycin, crizotinib,
fluoxetine, fluvoxamine, insulin degludec, insulin Back pain (<10%) darunavir, diltiazem, efavirenz, erythromycin,
detemir, insulin glargine, levodopa, lithium, Dystonia [6] etravirine, fluconazole, fosamprenavir, grapefruit
tetrabenazine, valproic acid Myalgia/Myopathy [2] juice, imatinib, indinavir, itraconazole,
Pregnancy category: C Rhabdomyolysis [9] ketoconazole, lopinavir, modafinil, nafcillin,
Important contra-indications noted in the Gastrointestinal/Hepatic nefazodone, nelfinavir, phenytoin, posaconazole,
prescribing guidelines for: the elderly; nursing Abdominal pain (<10%) rifampin, ritonavir, saquinavir, St John’s wort,
mothers; pediatric patients Constipation (9–11%) [2] strong and moderate CYP3A inhibitors,
Note: Can cause DRESS and other serious skin Diarrhea (<10%) [2] telaprevir, telithromycin, verapamil, voriconazole
reactions. Dyspepsia (7–11%) Pregnancy category: D
Symbyax is olanzapine and fluoxetine; Zypraxa Flatulence (<10%) Important contra-indications noted in the
Relprevv is olanzapine pamoate. Hepatotoxicity [4] prescribing guidelines for: nursing mothers;
Warning: INCREASED MORTALITY IN Nausea (<10%) pediatric patients
ELDERLY PATIENTS WITH DEMENTIA- Pancreatitis [7]
RELATED PSYCHOSIS Vomiting (<10%) Skin
POST-INJECTION DELIRIUM/SEDATION SYN- Respiratory Eczema (<10%)
DROME (Zyprexa Relprevv) Cough (<10%) Hot flashes (<10%)
Nasopharyngitis [2] Peripheral edema (10–20%)
Skin Pharyngitis (<10%) Pruritus (<10%)
Angioedema [2] Pneumonia [2] Rash (25%) [2]
Edema [3] Pulmonary embolism [3] Xerosis (<10%)
Hypersensitivity [2] Rhinitis (<10%) Hair
Peripheral edema (<10%) [5] Sinusitis (<10%) Alopecia [2]
Psoriasis [2] Endocrine/Metabolic Mucosal
Purpura (<10%) Appetite increased [2] Stomatitis (<10%)
Rash (>2%) [2] Diabetes mellitus [7]
Vesiculobullous eruption (2%) Diabetic ketoacidosis [2] Cardiovascular
Xanthomas [2] Galactorrhea [2] Hypertension (<10%) [2]
Glucose dysregulation [3] Venous thromboembolism (<10%)
Hair
Alopecia [3] Gynecomastia [2] Central Nervous System
Hypercholesterolemia [2] Anxiety (<10%)
Mucosal Hyperglycemia [6] Depression (<10%)
Epistaxis (nosebleed) (<10%) Hyperprolactinemia [2] Dysgeusia (taste perversion) (21%) [2]
Sialorrhea [4] Metabolic syndrome [11] Fever (<10%)
Xerostomia (13%) [11] Weight gain (5–40%) [60] Headache (25%) [4]
Cardiovascular Genitourinary Insomnia (<10%)
Hypertension (<10%) Priapism [19] Peripheral neuropathy (<10%) [2]
Hypotension (<10%) [4] Sexual dysfunction [2] Neuromuscular/Skeletal
Orthostatic hypotension [2] Urinary incontinence (<10%) Arthralgia (21–32%)
QT prolongation [6] Urinary tract infection (<10%) Asthenia (fatigue) (66–68%) [18]
Tachycardia (<10%) Back pain (25%)
Torsades de pointes [3] Hematologic
Agranulocytosis [2] Myalgia/Myopathy (22–25%)
Venous thromboembolism [4]
Dyslipidemia [4] Gastrointestinal/Hepatic
Central Nervous System Eosinophilia [2] Abdominal pain (43–47%) [3]
Akathisia (<10%) [7] Neutropenia [4] Constipation (10–20%) [2]
Amnesia [2] Pancytopenia [2] Diarrhea (28–31%) [8]
Compulsions [2] Dyspepsia (25%) [3]
Confusion [2] Ocular
Amblyopia (<10%) Gastric obstruction [2]
Delirium [6] Nausea (64–75%) [14]
Extrapyramidal symptoms [3] Oculogyric crisis [2]
Vision blurred [2] Vomiting (32–43%) [10]
Fever [2]
Hallucinations [2] Other Respiratory
Headache (17%) [3] Adverse effects [9] Cough (21%) [2]
Insomnia (12%) [3] Death [7] Dyspnea (10–20%)
Neuroleptic malignant syndrome [35] Nasopharyngitis (26–43%)
Parkinsonism (<10%) [6] Pharyngitis (43%)
Psychosis [2] Pulmonary embolism (<10%)
Restless legs syndrome [7] Upper respiratory tract infection (26–43%)
Restlessness [2]
Litt’s Drug Eruption & Reaction Manual OLOPATADINE
Endocrine/Metabolic Hematologic
ALT increased [2] Lymphopenia (77%) OLODATEROL
Appetite decreased (22–25%) [4] Neutropenia (65%) [2]
Creatine phosphokinase increased (26–30%) Prothrombin time increased (33%) Trade names: Stiolto Respimat (Boehringer
Hyperglycemia (<10%) Thrombocytopenia (63%) Ingelheim), Striverdi Respimat (Boehringer
Hypomagnesemia (<10%) Ingelheim)
Ocular Indications: Chronic obstructive pulmonary
Genitourinary Xerophthalmia (11%) disease including chronic bronchitis and
Dysuria (<10%) Local emphysema
Urinary incontinence (<10%) Infusion-related reactions (13%) Class: Beta-2 adrenergic agonist
Urinary tract infection (10–20%) Half-life: 8 hours
Anemia (25–34%) [17]
OLMESARTAN interactions with: adrenergics, beta blockers,
diuretics, MAO inhibitors, QT interval prolonging
Leukopenia (<10%) [3] Trade names: Benicar (Sankyo), Olmetec agents, steroids, tricyclic antidepressants,
Lymphopenia (56%) (Daiichi Sankyo) xanthine derivatives
Myelodysplastic syndrome [2] Indications: Hypertension Pregnancy category: C
Myeloid leukemia [2] Class: Angiotensin II receptor antagonist Important contra-indications noted in the
Neutropenia (25–32%) [12] (blocker), Antihypertensive prescribing guidelines for: nursing mothers;
Thrombocytopenia (26–30%) [8] Half-life: ~13 hours pediatric patients
Other Clinically important, potentially hazardous Note: Stiolto Respimat is olodaterol and
Adverse effects [5] interactions with: ACE inhibitors, adrenergic tiotropium.
Death [3] neurone blockers, aldesleukin, aliskiren, Warning: ASTHMA-RELATED DEATH
alprostadil, amifostine, antihypertensives,
antipsychotics, anxiolytics and hypnotics, Skin
OLARATUMAB baclofen, beta blockers, calcium channel blockers, Rash (2%)
clonidine, colesevelam, corticosteroids, Cardiovascular
Trade name: Lartruvo (Lilly) cyclosporine, diazoxide, diuretics, eltrombopag, Hypertension [2]
Indications: Treatment of adult patients with soft eplerenone, estrogens, general anesthetics,
heparins, hydralazine, levodopa, lithium, MAO Central Nervous System
tissue sarcoma (with doxorubicin) with a Fever (>2%)
histologic subtype for which an anthracycline- inhibitors, methyldopa, methylphenidate,
minoxidil, moxisylyte, moxonidine, nitrates, Headache [3]
containing regimen is appropriate and which is Vertigo (dizziness) (2%) [2]
not amenable to curative treatment with nitroprusside, NSAIDs, pentoxifylline,
radiotherapy or surgery phosphodiesterase 5 inhibitors, potassium salts, Neuromuscular/Skeletal
Class: Monoclonal antibody, Platelet-derived quinine, rituximab, tacrolimus, tizanidine, Arthralgia (2%) [2]
growth factor receptor alpha blocking antibody tolvaptan, trimethoprim Back pain (4%) [4]
Half-life: ~11 days Pregnancy category: D (category C in first Gastrointestinal/Hepatic
Clinically important, potentially hazardous trimester; category D in second and third Constipation (>2%)
interactions with: none known trimesters) Diarrhea (3%) [3]
Pregnancy category: N/A (Can cause fetal Important contra-indications noted in the
harm) Bronchitis (5%) [4]
Important contra-indications noted in the pediatric patients
Note: Contra-indicated in patients with diabetes. COPD [2]
prescribing guidelines for: the elderly; nursing Cough (4%) [3]
mothers; pediatric patients Warning: FETAL TOXICITY
Dyspnea [3]
Note: See separate entry for doxorubicin. Nasopharyngitis (11%) [4]
Skin Pneumonia (>2%) [3]
Hair Angioedema [3] Upper respiratory tract infection (8%) [4]
Alopecia (52%) Edema [2]
Peripheral edema [2] Genitourinary
Mucosal Urinary tract infection (3%) [3]
Mucositis (53%) [2] Cardiovascular
Hypotension [2]
Anxiety (11%) Central Nervous System OLOPATADINE
Headache (20%) Vertigo (dizziness) (3%) [8]
Neurotoxicity (22%) Neuromuscular/Skeletal Trade names: Pataday (Alcon), Patanol (Alcon)
Neuromuscular/Skeletal Asthenia (fatigue) [2] Indications: Pruritus due to allergic
Asthenia (fatigue) (64%) Gastrointestinal/Hepatic conjunctivitis, rhinitis
Bone or joint pain (64%) Diarrhea [4] Class: Histamine H1 receptor antagonist
Enteropathy [20] Half-life: 3 hours
Gastrointestinal/Hepatic Clinically important, potentially hazardous
Abdominal pain (23%) Gastrointestinal disorder [6]
Diarrhea (34%) [3] Respiratory Pregnancy category: C
Nausea (73%) [2] Upper respiratory tract infection [2] Important contra-indications noted in the
Vomiting (45%) [2] Endocrine/Metabolic prescribing guidelines for: nursing mothers;
Endocrine/Metabolic Hyperkalemia [3] pediatric patients
ALP increased (16%) Other
Appetite decreased (31%) Adverse effects [6] Central Nervous System
Hyperglycemia (52%) Headache (7%) [2]
Hypokalemia (21%)
Hypomagnesemia (16%) Ocular
Eyelid burning (<5%)
OLOPATADINE Over 100 updates per week on www.drugeruptiondata.com
Eyelid edema (<5%) Anxiety (<10%) Conjunctivitis (<10%)

Eyelid stinging (<5%) Cerebral hemorrhage (<10%) Diplopia (<10%)
Chills (13%) Eyelid edema (<10%)
Confusion (<10%) Lacrimation (<10%)
OLSALAZINE Depression (<10%)
Ocular pain (<10%)
See: www.drugeruptiondata.com/drug/id/512 Fever (24–29%) [4] Xerophthalmia (<10%)
Headache (13%) [4] Local
Hypoesthesia (<10%) Infusion-site reactions (22–34%)
Insomnia (10%)
OMACETAXINE Mood changes (<10%)
Injection-site reactions (22–34%)
Paresthesias (<10%) Other
Trade name: Synribo (Ivax) Seizures (<10%) Infection (46–56%) [3]
Indications: Chronic myeloid leukemia (CML) in Tremor (<10%)
patients with resistance and/or intolerance to two Vertigo (dizziness) (<10%)
or more tyrosine kinase inhibitors
Class: Protein synthesis inhibitor Neuromuscular/Skeletal OMALIZUMAB
Half-life: ~6 hours Arthralgia (19%)
Asthenia (fatigue) (23–31%) [5] Trade name: Xolair (Genentech)
Clinically important, potentially hazardous Indications: Asthma
interactions with: none known Back pain (11%)
Bone or joint pain (<10%) Class: IgE-targeting monoclonal antibody,
Pregnancy category: D Monoclonal antibody
Important contra-indications noted in the Gouty tophi (<10%)
Muscle spasm (<10%) Half-life: 26 days
prescribing guidelines for: the elderly; nursing Clinically important, potentially hazardous
mothers; pediatric patients Myalgia/Myopathy (<10%)
Pain in extremities (11–13%) interactions with: none known
Skin Gastrointestinal/Hepatic Important contra-indications noted in the
Burning (<10%) Abdominal distension (<10%) prescribing guidelines for: nursing mothers
Ecchymoses (<10%) Abdominal pain (13–14%) Warning: ANAPHYLAXIS
Edema (<10%) Black stools (<10%)
Erythema (<10%) Constipation (15%)
Diarrhea (35–42%) [6] Skin
Exfoliative dermatitis (<10%) Anaphylactoid reactions/Anaphylaxis [10]
Hematoma (<10%) Dyspepsia (<10%)
Gastritis (<10%) Angioedema [2]
Hot flashes (<10%) Churg-Strauss syndrome [13]
Hyperhidrosis (<10%) Gastroesophageal reflux (<10%)
Gastrointestinal bleeding (<10%) Dermatitis (2%)
Hypersensitivity (<10%) Pruritus (2%)
Lesions (<10%) Hemorrhoids (<10%)
Nausea (32%) [6] Rash [2]
Peripheral edema (13%) Serum sickness [2]
Petechiae (<10%) Vomiting (12–15%)
Serum sickness-like reaction [2]
Pigmentation (<10%) Respiratory Urticaria (7%) [3]
Pruritus (<10%) Cough (15–16%)
Purpura (<10%) Dysphonia (<10%) Central Nervous System
Rash (10%) Dyspnea (11%) Headache (15%) [8]
Ulcerations (<10%) Hemoptysis (<10%) Pain (7%)
Xerosis (<10%) Pharyngolaryngeal pain (<10%) Vertigo (dizziness) (3%)
Hair Endocrine/Metabolic Neuromuscular/Skeletal
Alopecia (15%) ALT increased (2–6%) Arthralgia (8%) [2]
Appetite decreased (<10%) Asthenia (fatigue) (3%) [2]
Mucosal Myalgia/Myopathy [2]
Aphthous stomatitis (<10%) Creatine phosphokinase increased (9–16%)
Epistaxis (nosebleed) (11–15%) Dehydration (<10%) Gastrointestinal/Hepatic
Gingival bleeding (<10%) Diabetes mellitus (<10%) Abdominal pain [3]
Nasal congestion (<10%) Genitourinary Diarrhea [2]
Oral bleeding (<10%) Dysuria (<10%) Nausea [3]
Oral ulceration (<10%) Hematologic Respiratory
Rhinorrhea (<10%) Anemia (51–61%) [6] Cough [2]
Stomatitis (<10%) Bone marrow suppression (10%) Nasopharyngitis [4]
Xerostomia (<10%) Febrile neutropenia (10–20%) Sinusitis (16%) [4]
Cardiovascular Hemoglobin decreased (62–80%) Upper respiratory tract infection (20%) [5]
Acute coronary syndrome (<10%) Leukocytosis (6%) Local
Angina (<10%) Myelosuppression [2] Injection-site pain [2]
Arrhythmias (<10%) Neutropenia (50%) [7] Injection-site reactions (45%) [7]
Bradycardia (<10%) Platelets decreased (85–88%) Other
Extrasystoles (<10%) Thrombocytopenia (56–74%) [8] Adverse effects [5]
Hypertension (<10%) Otic Infection [2]
Hypotension (<10%) Ear pain (<10%)
Palpitation (<10%) Ototoxicity (<10%)
Tachycardia (<10%) Tinnitus (<10%)
Central Nervous System Ocular
Agitation (<10%) Cataract (<10%)
Anorexia (13%) Conjunctival hemorrhage (<10%)
Litt’s Drug Eruption & Reaction Manual ONDANSETRON
ALT increased [3] Central Nervous System

OMBITASVIR/ AST increased [3] Anorexia [3]
Dysgeusia (taste perversion) (<10%) [4]
PARITAPREVIR/ Hematologic
Headache (7%) [2]
Anemia [6]
RITONAVIR Hemoglobin decreased [2] Paresthesias [2]
Other Vertigo (dizziness) (2%)
Trade names: Technivie (AbbVie), Viekira Pak Adverse effects [2]
(AbbVie), Viekirax (AbbVie) Death [2] Neuromuscular/Skeletal
Indications: Genotype 4 chronic hepatitis C virus Asthenia (fatigue) [2]
infection in patients without cirrhosis (in Myalgia/Myopathy (<10%)
combination with ribavirin) Rhabdomyolysis [2]
Class: CYP3A4 inhibitor (ritonavir), Direct-acting OMEPRAZOLE Gastrointestinal/Hepatic
antiviral, Hepatitis C virus NS3/4A protease
Trade names: Prilosec (AstraZeneca), Yosprala Abdominal distension [2]
inhibitor (paritaprevir), Hepatitis C virus NS5A
(Aralez) Abdominal pain (5%) [4]
inhibitor (ombitasvir)
Indications: Duodenal ulcer, gastric ulcer, Constipation [3]
Half-life: 21–25 hours (ombitasvir); 6 hours
gastroesophageal reflux disease (GERD), erosive Diarrhea (4%) [9]
(paritaprevir); 4 hours (ritonavir)
esophagitis Flatulence (3%)
Class: CYP1A2 inducer, Proton pump inhibitor Hepatitis [4]
interactions with: atazanavir, carbamazepine,
(PPI) Hepatotoxicity [3]
cisapride, colchicine, dihydroergotamine,
Half-life: 0.51 hour Nausea (4%) [7]
dronedarone, efavirenz, ergotamine, ethinyl
Clinically important, potentially hazardous Pancreatitis [2]
estradiol-containing medications, lopinavir,
interactions with: amoxicillin, atazanavir, Vomiting (3%) [6]
lovastatin, lurasidone, methylergonovine,
midazolam, midostaurin, neratinib, phenobarbital, bendamustine, benzodiazepines, cilostazol, Respiratory
phenytoin, pimozide, ranolazine, rifampin, clarithromycin, clobazam, clopidogrel, clozapine, Cough [2]
rilpivirine, salmeterol, sildenafil, simvastatin, St coumarins, cyclosporine, dasatinib, delavirdine, Upper respiratory tract infection (2%)
John’s wort, triazolam, voriconazole diazepam, digoxin, disulfiram, enzalutamide, Endocrine/Metabolic
Pregnancy category: B (pregnancy category will erlotinib, escitalopram, itraconazole,
Gynecomastia [11]
be X when administered with ribavirin) ketoconazole, lapatinib, methotrexate, nelfinavir,
Hypomagnesemia [7]
Important contra-indications noted in the phenytoin, posaconazole, prednisone, raltegravir,
rilpivirine, saquinavir, sofosbuvir & velpatasvir, St Renal
John’s wort, tacrolimus, tipranavir, ulipristal, Nephrotoxicity [9]
pediatric patients
Note: Contra-indicated in patients with voriconazole, warfarin Hematologic
moderate or severe hepatic impairment or with Pregnancy category: C Agranulocytosis [3]
known hypersensitivity to ritonavir (see separate Important contra-indications noted in the Hemolytic anemia [2]
entry). See also separate entry for ribavirin. prescribing guidelines for: nursing mothers; Leukopenia [3]
Viekira Pak is ombitasvir/paritaprevir/ritonavir co- pediatric patients Neutropenia [3]
packaged with dasabuvir. Note: Yosprala is omeprazole and aspirin.
Ocular
Visual disturbances [2]
Skin Skin
Other
Dermatitis (<5%) AGEP [2]
Adverse effects [9]
Eczema (<5%) Anaphylactoid reactions/Anaphylaxis [7]
Erythema (<5%) Angioedema [5]
Exfoliative dermatitis (<5%) Baboon syndrome (SDRIFE) [2]
Photosensitivity (<5%) Bullous pemphigoid [2] ONDANSETRON
Pruritus (5%) [8] Contact dermatitis [2]
Eczema [2] Trade names: Zofran (GSK), Zuplenz (Par)
Psoriasis (<5%)
Edema (<10%) [2] Indications: Nausea and vomiting
Rash (<5%) [4]
Erythroderma [2] Class: 5-HT3 antagonist, Antiemetic, Serotonin
Ulcerations (<5%)
Exfoliative dermatitis [3] type 3 receptor antagonist
Urticaria (<5%)
Hypersensitivity [2] Half-life: 3–6 hours
Central Nervous System Lichen planus [2] Clinically important, potentially hazardous
Headache [17] Lichen spinulosus [2] interactions with: apomorphine,
Insomnia (5%) [11] Lichenoid eruption [2] carbamazepine, phenytoin, ribociclib, rifampin,
Irritability [2] Lupus erythematosus [5] tramadol
Vertigo (dizziness) [2] Pemphigus (exacerbation) [2] Pregnancy category: B
Neuromuscular/Skeletal Peripheral edema [2] Important contra-indications noted in the
Arthralgia [2] Pruritus (<10%) [8] prescribing guidelines for: nursing mothers;
Asthenia (fatigue) (7–25%) [17] Rash (2%) [6] pediatric patients
Gastrointestinal/Hepatic Toxic epidermal necrolysis [5]
Diarrhea [10] Urticaria (<10%) [9] Skin
Nausea (9%) [13] Vasculitis [2] Anaphylactoid reactions/Anaphylaxis [5]
Vomiting [2] Xerosis [2] Fixed eruption [2]
Hair Pruritus (5%)
Respiratory
Cough [3] Alopecia [2] Mucosal
Dyspnea [2] Mucosal Sialopenia (<5%)
Nasopharyngitis [2] Oral candidiasis [3] Xerostomia (<10%) [3]
Endocrine/Metabolic Xerostomia (<10%) [2] Cardiovascular
Acidosis [2] Bradycardia [2]
Flushing [2]
ONDANSETRON See all our books at www.crcpress.com
Hypotension [3] wort, teriflunomide, tigecycline, triamcinolone,

Myocardial ischemia [2] troleandomycin, tuberculostatics, ursodiol, ORITAVANCIN
QT prolongation [11] zolmitriptan
Torsades de pointes [3] Warning: CIGARETTE SMOKING AND Trade name: Orbactiv (Medicines Co)
Ventricular tachycardia [2] SERIOUS CARDIOVASCULAR EVENTS Indications: Acute bacterial skin and skin
structure infections caused or suspected to be
Central Nervous System caused by susceptible isolates of designated
Anxiety (6%) Skin Gram-positive microorganisms
Chills (510%) Acneform eruption [17] Class: Antibiotic, lipoglycopeptide
Fever (2–8%) Angioedema [4] Half-life: 245 hours
Headache (17–25%) [14] Candidiasis [9] Clinically important, potentially hazardous
Paresthesias (2%) Chloasma [13] interactions with: warfarin
Seizures [3] Erythema multiforme [2] Pregnancy category: C
Somnolence (drowsiness) (8%) [4] Erythema nodosum [18] Important contra-indications noted in the
Vertigo (dizziness) (4–7%) [8] Exanthems [2] prescribing guidelines for: nursing mothers;
Neuromuscular/Skeletal Herpes gestationis [3] pediatric patients
Asthenia (fatigue) (9–13%) Lupus erythematosus [29]
Melanoma [5]
Gastrointestinal/Hepatic Melasma [8] Skin
Abdominal pain [2] Perioral dermatitis [8] Abscess (4%) [3]
Constipation (6–11%) [7] Photosensitivity [12] Angioedema (<2%)
Diarrhea (8–16%) [3] Pigmentation [18] Cellulitis [4]
Respiratory Pruritus [5] Erythema multiforme (<2%)
Hypoxia (9%) Purpura [3] Hypersensitivity (<2%)
Seborrhea [3] Leukocytoclastic vasculitis (<2%)
Endocrine/Metabolic Pruritus (<2%) [3]
ALT increased [2] Spider angioma [2]
Sweet’s syndrome [2] Rash (<2%)
Local Telangiectasia [6] Urticaria (<2%)
Injection-site reactions (4%) Urticaria [2] Cardiovascular
Other Hair Phlebitis [2]
Adverse effects [3] Alopecia [19] Tachycardia (3%)
Death [2] Alopecia areata [4] Central Nervous System
Hiccups [2] Hirsutism [12] Fever [4]
Mucosal Headache (7%) [6]
Gingival hyperplasia/hypertrophy [2] Vertigo (dizziness) (3%) [4]
ORAL Cardiovascular Neuromuscular/Skeletal
CONTRACEPTIVES Thrombophlebitis [2]
Osteomyelitis (<2%)
Venous thromboembolism [6]
Trade names: Alesse (Wyeth), Aviane (Barr), Central Nervous System Gastrointestinal/Hepatic
Brevicon (Watson), Demulen (Pfizer), Desogen Chorea [2] Constipation [5]
(Organon), Estrostep (Pfizer), Evra (Johnson & Depression [2] Diarrhea (4%) [6]
Johnson), Levlen (Bayer), Levlite (Bayer), Levora Headache [3] Nausea (10%) [7]
(Watson), Lo/Ovral (Wyeth), Loestrin (Barr), Vomiting (5%) [5]
Lunelle (Pfizer), Mircette (Organon), Modicon Respiratory
Colitis [3]
(Ortho), Necon (Watson), Nordette (Monarch), Bronchospasm (<2%)
Nausea [4]
Norinyl (Watson), Ortho Tri-Cyclen (Ortho- Wheezing (<2%)
McNeil), Ortho-Cept (Ortho-McNeil), Ortho- Endocrine/Metabolic
Cyclen (Ortho-McNeil), Ortho-Novum (Ortho- Acute intermittent porphyria [5] Endocrine/Metabolic
McNeil), Ovcon (Warner Chilcott), Ovral Galactorrhea [2] ALT increased (3%) [4]
(Wyeth), Tri-Levlen (Bayer), Tri-Norinyl (Watson), Mastodynia [3] AST increased (2%) [2]
Triphasil (Wyeth), Trivora (Watson), Yasmin Porphyria cutanea tarda [28] Hyperuricemia (<2%)
(Bayer), Yaz (Bayer), Zovia (Watson) Porphyria variegata [2] Hypoglycemia (<2%)
Indications: Prevention of pregnancy Genitourinary Hematologic
Class: Hormone Vaginal bleeding [4] Anemia (<2%)
Half-life: N/A Eosinophilia (<2%)
Local
Application-site reactions (92%) [2] Local
interactions with: aminophylline, amprenavir, Infusion-site reactions (2%) [3]
anticonvulsants, aprepitant, atazanavir, Other Injection-site extravasation [3]
atorvastatin, beclomethasone, bexarotene, Adverse effects [3] Injection-site phlebitis [3]
bosentan, budesonide, cigarette smoking, Injection-site reactions [2]
danazol, doxycycline, efavirenz, eslicarbazepine,
exenatide, flucloxacillin, flunisolide, fluticasone
propionate, glecaprevir & pibrentasvir,
hydrocortisone, insulin aspart, insulin degludec,
insulin detemir, insulin glargine, insulin glulisine,
isotretinoin, lamotrigine, lomitapide, lymecycline,
metformin, methylprednisolone, mifepristone,
modafinil, naratriptan, nelfinavir, oxcarbazepine,
perampanel, prednisolone, prednisone, rifabutin,
rifampin, ritonavir, roflumilast, selegiline, St John’s
Litt’s Drug Eruption & Reaction Manual OSPEMIFENE
Otic Pregnancy category: N/A (Can cause fetal

ORLISTAT Otitis media (3–4%) harm)
Other Important contra-indications noted in the
Trade names: Alli (GSK), Xenical (Roche) prescribing guidelines for: nursing mothers;
Indications: Obesity, weight reduction Adverse effects [7]
Tooth disorder (3–4%) pediatric patients
Class: Lipase inhibitor
Half-life: 12 hours
Rash (41%) [7]
interactions with: acarbose, amiodarone, ORPHENADRINE Xerosis (31%) [2]
antiepileptics, coumarins, cyclosporine,
ergocalciferol, ethosuximide, lacosamide, See: www.drugeruptiondata.com/drug/id/517 Nails
levothyroxine, oxcarbazepine, paricalcitol, Nail toxicity (25%)
phytonadione, tiagabine, vigabatrin, vitamin A, Paronychia [2]
vitamin E, warfarin
OSELTAMIVIR Mucosal
Stomatitis (12%)
Important contra-indications noted in the Trade name: Tamiflu (Roche)
prescribing guidelines for: nursing mothers; Cardiovascular
Indications: Influenza infection QT prolongation (3%)
pediatric patients Class: Antiviral, Neuraminidase inhibitor
Note: Contra-indicated in organ transplant Venous thromboembolism (7%)
recipients. Orlistat interferes with the medicines Clinically important, potentially hazardous Central Nervous System
used to prevent transplant rejection. interactions with: none known Cerebrovascular accident (3%)
Pregnancy category: C Headache (10%)
Lichenoid eruption [2] Skin Asthenia (fatigue) (14%) [2]
Peripheral edema (3%) Rash [5] Back pain (13%)
Rash (4%) Toxic epidermal necrolysis [2] Gastrointestinal/Hepatic
Xerosis (2%) Constipation (15%)
Mucosal Delirium [5] Diarrhea (42%) [7]
Gingivitis (2–4%) Hallucinations [3] Nausea (17%) [2]
Central Nervous System Headache [2] Respiratory
Anxiety (3–5%) Insomnia [2] Cough (14%)
Depression (3%) Neuropsychiatric disturbances [3] Dyspnea [2]
Headache (31%) [2] Neurotoxicity [5] Pneumonia (4%)
Sleep related disorder (4%) Seizures [2] Pneumonitis (3%)
Vertigo (dizziness) (5%) Suicidal ideation [2] Pulmonary toxicity [5]
Neuromuscular/Skeletal Gastrointestinal/Hepatic Endocrine/Metabolic
Arthralgia (5%) Abdominal pain (2–5%) [2] Appetite decreased (16%) [2]
Asthenia (fatigue) (3–7%) Diarrhea (<3%) [8] Hypermagnesemia (20%)
Back pain (14%) Hemorrhagic colitis [5] Hyponatremia (26%)
Bone or joint pain (2%) Nausea (4–10%) [16] Hematologic
Myalgia/Myopathy (4%) Vomiting (2–15%) [16] Anemia (44%)
Tendinitis (2%) Respiratory Lymphopenia (63%)
Gastrointestinal/Hepatic Respiratory failure [2] Neutropenia (33%)
Abdominal pain (26%) [4] Upper respiratory tract infection [2] Thrombocytopenia (54%)
Cholelithiasis (gallstones) (3%) Hematologic Ocular
Defecation (increased) (3–11%) [2] Thrombocytopenia [2] Ocular adverse effects (18%)
Fecal incontinence (2–8%)
Fecal urgency (3–23%) [2] Other
Flatulence (with discharge) (2–24%) [2] Adverse effects [7]
Hepatic failure [2] OSPEMIFENE
Hepatitis [3]
Hepatotoxicity [4] OSIMERTINIB Trade name: Osphena (Shionogi)
Indications: Dyspareunia due to menopausal
Nausea (4–8%)
Pancreatitis [5] Trade name: Tagrisso (AstraZeneca) vulvar and vaginal atrophy
Vomiting (4%) Indications: Metastatic epidermal growth factor Class: Estrogen agonist, Estrogen antagonist,
receptor T790M mutation-positive non-small cell Selective estrogen receptor modulator (SERM)
Respiratory Half-life: 26 hours
Influenza (40%) lung cancer
Class: Kinase inhibitor Clinically important, potentially hazardous
Upper respiratory tract infection (26–38%) interactions with: fluconazole, ketoconazole,
[2] Half-life: 48 hours
Clinically important, potentially hazardous other estrogen agonists or antagonists, rifampin
Endocrine/Metabolic interactions with: carbamazepine, cyclosporine, Pregnancy category: X
Hypoglycemia (in diabetic patients) [2] ergot alkaloids, fentanyl, itraconazole, Important contra-indications noted in the
Menstrual irregularities (10%) nefazodone, phenytoin, quinidine, rifampin, prescribing guidelines for: nursing mothers;
Genitourinary ritonavir, St John’s wort, strong CYP3A inhibitors pediatric patients
Urinary tract infection (6–8%) or inducers, telithromycin Note: Contra-indicated in patients with
Vaginitis (3–4%) undiagnosed abnormal genital bleeding, known or
suspected estrogen-dependent neoplasia, active
Renal DVT or pulmonary embolism, or active arterial
Nephrotoxicity [9] thromboembolic disease.
Renal failure [2]
OSPEMIFENE Over 100 updates per week on www.drugeruptiondata.com
Warning: ENDOMETRIAL CANCER AND Purpura (25%) Pulmonary fibrosis [2]

CARDIOVASCULAR DISORDERS Radiation recall dermatitis [3] Pulmonary toxicity [2]
Rash (5–11%) [11] Rhinitis (4–10%)
Skin Thrombocytopenic purpura [2] Upper respiratory tract infection (4%)
Hot flashes (8%) [7] Toxicity [2] Endocrine/Metabolic
Hyperhidrosis (2%) Urticaria [2] ALP increased (42%)
Xerosis (6%) ALT increased (57%)
Muscle spasm (3%) Hair AST increased [2]
Alopecia (3–38%) [3] Dehydration (9%)
Genitourinary Hyperglycemia (14%)
Urinary tract infection [2] Mucosal
Epistaxis (nosebleed) (<16%) Hypoalbuminemia (8%)
Vaginal discharge (4%) Hypocalcemia (7%)
Gingivitis (25%)
Mucositis (10%) [4] Hypokalemia (11%)
Oral mucositis [2] Hyponatremia (8%) [2]
OXACILLIN Stomatitis (32–42%) [3] Serum creatinine increased (4%) [2]
Xerostomia (5%) Weight gain (10%)
Indications: Various infections caused by Weight loss (11%)
susceptible organisms Cardiovascular
Chest pain (4%) [2] Genitourinary
Class: Antibiotic, penicillin Urinary frequency (5%)
Half-life: 2360 minutes Flushing (2–7%) [2]
Clinically important, potentially hazardous Hypertension [5] Renal
interactions with: anticoagulants, cyclosporine, Hypotension (5%) [2] Nephrotoxicity [3]
demeclocycline, doxycycline, imipenem/cilastatin, Tachycardia [3] Hematologic
methotrexate, minocycline, oxytetracycline, Thromboembolism (4%) Anemia (27–76%) [24]
tetracycline Central Nervous System Febrile neutropenia (<4%) [7]
Pregnancy category: B Anorexia (13–35%) [4] Hemolytic anemia [4]
Important contra-indications noted in the Anxiety (5%) Leukocytopenia [2]
prescribing guidelines for: the elderly; nursing Chills [3] Leukopenia (34–85%) [14]
mothers; pediatric patients Depression (9%) Lymphopenia (6%)
Dysesthesia (often cold-induced or cold- Myelosuppression [4]
Skin exacerbated) (38%) [7] Neutropenia (25–81%) [52]
Exanthems [2] Dysgeusia (taste perversion) (<14%) Thrombocytopenia (20–77%) [38]
Rash (<22%) Dysphasia (5%) Thrombosis (6%)
Fever (16–27%) [9] Ocular
Other Headache (7–13%)
Adverse effects [2] Abnormal vision (5%)
Hyperalgesia [2] Conjunctivitis (9%)
Hypoesthesia [2] Epiphora [3]
Insomnia (4–13%) Lacrimation (4–9%)
OXALIPLATIN Leukoencephalopathy [4] Vision blurred [2]
Neurotoxicity (48%) [37]
Trade name: Eloxatin (Sanofi-Aventis) Pain (5–9%) Local
Indications: Metastatic carcinoma of the colon Paresthesias (77%) [7] Injection-site reactions (5–11%) [2]
or rectum (in combination with fluorouracil/ Peripheral neuropathy (92%) [38] Other
leucovorin (FOLFOX)) Rigors (8%) Adverse effects [2]
Class: Alkylating agent, Antineoplastic Sensory disturbances (8%) Allergic reactions (3%) [4]
Half-life: 391 hours Vertigo (dizziness) (7–8%) Death [3]
Clinically important, potentially hazardous Neuromuscular/Skeletal Hiccups (5%)
interactions with: aminoglycosides, BCG Arthralgia (5–10%) Infection (8–25%) [2]
vaccine, capreomycin, cardiac glycosides, Asthenia (fatigue) (44–70%) [21]
clozapine, denosumab, diuretics, leflunomide, Ataxia [2]
natalizumab, pimecrolimus, polymyxins,
sipuleucel-T, tacrolimus, taxanes, topotecan,
Back pain (11–16%) OXAPROZIN
trastuzumab, vaccines, vitamin K antagonists Trade name: Daypro (Pfizer)
Pregnancy category: D Gastrointestinal/Hepatic
Abdominal pain (18–31%) [4] Indications: Arthritis
Important contra-indications noted in the Class: Non-steroidal anti-inflammatory (NSAID)
prescribing guidelines for: nursing mothers; Constipation (22–32%) [2]
Diarrhea (44–56%) [41] Half-life: 4250 hours
pediatric patients Clinically important, potentially hazardous
Warning: ANAPHYLACTIC REACTIONS Dyspepsia (8–12%)
Flatulence (6–9%) interactions with: methotrexate
Gastroesophageal reflux (3%) Pregnancy category: C
Skin Hepatotoxicity [8] Important contra-indications noted in the
Anaphylactoid reactions/Anaphylaxis [11] Nausea (59–74%) [23] prescribing guidelines for: nursing mothers;
Diaphoresis (5%) [2] Sinusoidal obstruction syndrome [2] pediatric patients
Edema (13–15%) [2] Vomiting (27–47%) [19] Note: NSAIDs may cause an increased risk of
Erythema [4] serious cardiovascular and gastrointestinal
Exanthems (25%) Respiratory adverse events, which can be fatal. This risk may
Hand–foot syndrome (7–13%) [12] Cough (9–35%) increase with duration of use.
Hot flashes (25%) Dyspnea (5–18%) [2]
Hypersensitivity (12%) [29] Pharyngitis (10%)
Pneumonia [2] Skin
Peripheral edema (11%) Pruritus (<10%)
Pruritus (6%) [5] Pulmonary embolism [2]
Rash (>10%) [2]
Litt’s Drug Eruption & Reaction Manual OXYBUTYNIN
Stevens-Johnson syndrome [2] Pregnancy category: C Sinusitis (4%)

Toxic epidermal necrolysis [4] Important contra-indications noted in the Upper respiratory tract infection (5–10%)
Gastrointestinal/Hepatic prescribing guidelines for: nursing mothers; Endocrine/Metabolic
Hepatotoxicity [3] pediatric patients Hyponatremia (<5%) [16]
Endocrine/Metabolic SIADH [3]
Pseudoporphyria [3] Skin Weight gain (<2%)
Acneform eruption (<2%) Genitourinary
Renal Diaphoresis (3%)
Nephrotoxicity [2] Ejaculatory dysfunction [3]
DRESS syndrome [6] Urinary frequency (<2%)
Other Ecchymoses (4%) Urinary tract infection (<5%)
Adverse effects [3] Edema (<2%) Vaginitis (2%)
Exanthems [4]
Hot flashes (<2%) Hematologic
Hyperhidrosis (3%) Leukopenia [3]
OXAZEPAM Hypersensitivity [6] Thrombocytopenia [2]
Trade name: Serax (Mayne) Lymphadenopathy (2%) Otic
Indications: Anxiety, depression Purpura (2%) Ear pain (<2%)
Class: Benzodiazepine Rash (<6%) [11] Ocular
Half-life: 36 hours Stevens-Johnson syndrome [10] Abnormal vision (2–14%)
Clinically important, potentially hazardous Toxic epidermal necrolysis [4] Accommodation disorder (<3%)
interactions with: amprenavir, Mucosal Diplopia (<40%) [10]
chlorpheniramine, clarithromycin, efavirenz, Epistaxis (nosebleed) (4%) Nystagmus (2–26%)
esomeprazole, imatinib, nelfinavir Rectal hemorrhage (2%) Other
Pregnancy category: D Xerostomia (3%) Adverse effects [7]
Important contra-indications noted in the Cardiovascular Allergic reactions (2%) [3]
prescribing guidelines for: pediatric patients Chest pain (2%) Dipsia (thirst) (2%)
Hypotension (<3%) Infection (2–7%)
Skin Central Nervous System Teratogenicity [3]
Dermatitis (<10%) Agitation (<2%) Toothache (2%)
Diaphoresis (>10%) Amnesia (4%)
Rash (>10%) Anorexia (3–5%)
Mucosal Anxiety (5–7%) OXERUTINS
Sialopenia (>10%) Coma [2]
Sialorrhea (<10%) Confusion (<7%) See: www.drugeruptiondata.com/drug/id/1358
Xerostomia (>10%) Dysgeusia (taste perversion) (5%)
Emotional lability (2–3%)
Fever (3%) OXILAN
OXCARBAZEPINE Gait instability (5–17%)
Headache (13–32%) [8] See: www.drugeruptiondata.com/drug/id/1149
Trade names: Oxtellar XR (Supernus), Trileptal Hyperesthesia (3%)
(Novartis) Hypoesthesia (<3%)
Incoordination (<4%)
Indications: Partial epileptic seizures
Class: Anticonvulsant, CYP3A4 inducer, Mood Insomnia (2–6%) OXPRENOLOL
stabilizer Nervousness (2–4%)
Seizures (2–5%) [5] See: www.drugeruptiondata.com/drug/id/1391
Clinically important, potentially hazardous Somnolence (drowsiness) (5–36%) [5]
interactions with: alcohol, antipsychotics, Speech disorder (<3%)
carbamazepine, chloroquine, clopidogrel, Tremor (3–16%) [2] OXTRIPHYLLINE
cobicistat/elvitegravir/emtricitabine/tenofovir Vertigo (dizziness) (3–49%) [12]
alafenamide, cobicistat/elvitegravir/emtricitabine/ Neuromuscular/Skeletal See: www.drugeruptiondata.com/drug/id/1971
tenofovir disoproxil, cyclosporine, CYP3A4 Asthenia (fatigue) (3–15%) [5]
substrates, dronedarone, emtricitabine/rilpivirine/ Ataxia (<31%) [2]
tenofovir alafenamide, eslicarbazepine, Back pain (4%) OXYBUTYNIN
everolimus, exemestane, guanfacine, Myoclonus [3]
hydroxychloroquine, imatinib, ixabepilone, Osteoporosis [2] Trade names: Cystrin (Sanofi-Aventis), Ditropan
ledipasvir & sofosbuvir, levomepromazine, Gastrointestinal/Hepatic (Ortho-McNeil), Lyrinel (Janssen-Cilag)
levonorgestrel, MAO inhibitors, maraviroc, Abdominal pain (3–13%) Indications: Neurogenic bladder, urinary
mefloquine, nifedipine, nilotinib, nisoldipine, oral Constipation (2–6%) incontinence, palmar and axillary hyperhidrosis
contraceptives, orlistat, pazopanib, perampanel, Diarrhea (5–7%) Class: Anticholinergic, Antimuscarinic, Muscarinic
phenobarbital, phenytoin, praziquantel, Dyspepsia (5–6%) antagonist
ranolazine, rilpivirine, risperidone, romidepsin, Gastritis (<2%) Half-life: 2–3 hours
saxagliptin, selegiline, simeprevir, sofosbuvir, Nausea (15–29%) [8] Clinically important, potentially hazardous
sofosbuvir & velpatasvir, sofosbuvir/velpatasvir/ Vomiting (13–36%) [4] interactions with: alcohol, anticholinergics,
voxilaprevir, sorafenib, SSRIs, St John’s wort, antihistamines, arbutamine, cannabinoids,
tadalafil, tenofovir alafenamide, thiazide diuretics, Respiratory clozapine, conivaptan, diphenoxylate,
tolvaptan, tricyclic antidepressants, ulipristal, Cough (5%) disopyramide, domperidone, haloperidol,
valproic acid, zuclopenthixol Pharyngitis (3%) ketoconazole, levodopa, MAO inhibitors,
Pneumonia (2%) memantine, metoclopramide, nefopam, nitrates,
Rhinitis (2–5%)
OXYBUTYNIN See all our books at www.crcpress.com
parasympathomimetics, pramlintide, secretin, Warning: ADDICTION, ABUSE and MISUSE;

tricyclic antidepressants LIFETHREATENING RESPIRATORY OXYMORPHONE
Pregnancy category: B DEPRESSION; ACCIDENTAL INGESTION;
Important contra-indications noted in the NEONATAL OPIOID WITHDRAWAL Trade name: Opana (Endo)
prescribing guidelines for: nursing mothers SYNDROME; and CYTOCHROME P450 3A4 Indications: Pain (moderate to severe)
Note: Contra-indicated in patients with urinary INTERACTION Class: Analgesic, Opiate agonist
retention, gastric retention and other severe Half-life: 7–9 hours
decreased gastrointestinal motility conditions, Clinically important, potentially hazardous
Skin interactions with: anticholinergics,
uncontrolled narrow-angle glaucoma and in Pruritus [7]
patients who are at risk for these conditions. buprenorphine, butorphanol, cimetidine, CNS
Mucosal depressants, MAO inhibitors, nalbuphine,
Xerostomia [2] pentazocine
Skin Pregnancy category: C
Hot flashes (<10%) Central Nervous System
Fever [2] Important contra-indications noted in the
Pruritus [2] prescribing guidelines for: the elderly; nursing
Rash (<10%) Headache [6]
Insomnia [3] mothers; pediatric patients
Mucosal Sedation [2] Note: Contra-indicated in patients with a known
Sialopenia [2] Serotonin syndrome [2] hypersensitivity to morphine analogs such as
Xerostomia (71%) [31] Somnolence (drowsiness) [13] codeine; in patients with respiratory depression,
Central Nervous System Vertigo (dizziness) [8] except in monitored settings and in the presence
Cognitive impairment [4] of resuscitative equipment; in patients with acute
Neuromuscular/Skeletal or severe bronchial asthma or hypercarbia; in any
Headache (8%) [2] Asthenia (fatigue) [9]
Insomnia (6%) patient who has or is suspected of having paralytic
Nervousness (7%) Gastrointestinal/Hepatic ileus; and in patients with moderate or severe
Somnolence (drowsiness) (14%) Abdominal pain [3] hepatic impairment.
Vertigo (dizziness) (17%) [2] Constipation [12]
Diarrhea [2] Skin
Gastrointestinal/Hepatic Ileus [2]
Constipation (15%) [4] Hyperhidrosis (<10%)
Nausea [21] Pruritus (8%) [2]
Dyspepsia (6%) Vomiting [18]
Nausea [3] Mucosal
Ocular Xerostomia (<10%)
Genitourinary Hallucinations, visual [2]
Urinary retention (6%) Cardiovascular
Urinary tract infection (7%) Local Hypotension (<10%)
Injection-site pain (<10%) Tachycardia (<10%)
Ocular
Vision blurred (10%) Other Central Nervous System
Adverse effects [9] Anxiety (<10%)
Other Death [3]
Adverse effects [4] Confusion (3%)
Tooth disorder [2] Fever (14%)
Headache (7%)
Sedation (<10%)
OXYCODONE OXYMETAZOLINE * Somnolence (drowsiness) (9%) [2]
Vertigo (dizziness) (7%)
Trade name: Rhofade (Allergan) Gastrointestinal/Hepatic
Trade names: OxyContin (Purdue), OxyIR Indications: Persistant facial erythema associated
(Purdue), Percocet (Endo), Roxicodone Abdominal distension (<10%)
with rosacea Constipation (4%) [3]
(aaiPharma), Targiniq (Purdue), Troxyca (Pfizer), Class: Alpha adrenoceptor agonist
Tylox (Ortho-McNeil), Xtampza ER (Collegium) Flatulence (<10%)
Half-life: N/A Nausea (19%) [4]
Indications: Pain Clinically important, potentially hazardous
Class: Opiate agonist Vomiting (9%) [2]
Half-life: 4.6 hours Pregnancy category: N/A (No available data to Respiratory
Clinically important, potentially hazardous inform drug-associated risk) Hypoxia (<10%)
interactions with: cimetidine, clonazepam, Important contra-indications noted in the Local
telithromycin, voriconazole prescribing guidelines for: nursing mothers; Injection-site reactions (<10%)
Pregnancy category: B pediatric patients
Important contra-indications noted in the Note: For topical use only. See separate entry for
prescribing guidelines for: the elderly; nursing tetracaine & oxymetazoline as intranasal
mothers; pediatric patients formulation.
OXYTETRACYCLINE
Note: Oxycodone is often combined with Oxymetazoline is also available as an ophthalmic
acetaminophen (Percocet, Roxicet, Tylox) or See: www.drugeruptiondata.com/drug/id/525
solution and a nasal decongestant in over-the-
aspirin (Percodan, Roxiprin); Targiniq is counter products.
oxycodone and naloxone; Troxyca is oxycodone
and naltrexone. Contra-indicated in patients with
Skin
OXYTOCIN
significant respiratory depression, acute or severe
bronchial asthma, or with known or suspected Rosacea (exacerbation) (<3%) Trade name: Pitocin (Par)
gastrointestinal obstruction, including paralytic Local Indications: Induction of labor
ileus. Application-site dermatitis (<3%) Class: Oxytocic
Application-site pain (<2%) Half-life: N/A
Application-site pruritus (<2%) Clinically important, potentially hazardous
interactions with: cyclopropane, gemeprost,
halothane, prostaglandins
Litt’s Drug Eruption & Reaction Manual OXYTOCIN
Pregnancy category: X Mucosal Respiratory

Xerostomia [3] Hypoxia [2]
Skin Cardiovascular Genitourinary
Anaphylactoid reactions/Anaphylaxis [7] Bradycardia [2] Urinary frequency [3]
Uterine hyperstimulation [2]
PACLITAXEL Over 100 updates per week on www.drugeruptiondata.com
Bradycardia (3%) Injection-site extravasation (>10%) [4]

PACLITAXEL Cardiotoxicity [3] Injection-site pain (>10%)
Congestive heart failure [3] Injection-site reactions (13%) [2]
Trade name: Taxol (Bristol-Myers Squibb) Flushing (28%) [3]
Indications: Breast cancer and metastatic Other
Hypertension [12] Adverse effects [8]
carcinoma of the ovary Hypotension (4–12%)
Class: Antineoplastic, Taxane Allergic reactions (15%) [8]
Myocardial infarction [2] Death [12]
Half-life: 517 hours Tachycardia (2%)
Clinically important, potentially hazardous Infection (322%) [12]
interactions with: atazanavir, bexarotene, Central Nervous System Kounis syndrome [2]
buspirone, carbamazepine, cisplatin, Anorexia [6]
clarithromycin, delavirdine, doxorubicin, Dysgeusia (taste perversion) [3]
efavirenz, eletriptan, felodipine, gadobenate, Fever [4]
Headache [2]
PALBOCICLIB
gemfibrozil, indinavir, itraconazole, ketoconazole,
lapatinib, lovastatin, nefazodone, nelfinavir, Insomnia [2] Trade name: Ibrance (Pfizer)
repaglinide, rifampin, ritonavir, rosiglitazone, Neurotoxicity [39] Indications: Treatment of postmenopausal
saquinavir, sildenafil, simvastatin, telithromycin, Pain [9] women with estrogen receptor (ER)-positive,
teriflunomide, thalidomide, trastuzumab, Paresthesias (>10%) [5] human epidermal growth factor receptor 2
triazolam Peripheral neuropathy (42–70%) [35] (HER2)-negative advanced breast cancer (in
Pregnancy category: D Seizures [2] combination with letrozole)
Important contra-indications noted in the Vertigo (dizziness) [7] Class: Kinase inhibitor
prescribing guidelines for: the elderly; nursing Neuromuscular/Skeletal Half-life: 29 hours
mothers; pediatric patients Arthralgia (60%) [15] Clinically important, potentially hazardous
Note: Studies have shown that elderly patients Asthenia (fatigue) (17%) [54] interactions with: bosentan, carbamazepine,
have an increased risk of severe Bone or joint pain [3] clarithromycin, efavirenz, etravirine, grapefruit
myelosuppression, severe neuropathy and a Myalgia/Myopathy (1960%) [23] juice, indinavir, itraconazole, ketoconazole,
higher incidence of cardiovascular events. Gastrointestinal/Hepatic lopinavir, modafinil, nafcillin, nefazodone,
Abdominal pain (>10%) [2] nelfinavir, phenytoin, posaconazole, rifampin,
Skin Constipation [6] ritonavir, saquinavir, St John’s wort, telaprevir,
Acneform eruption [6] Diarrhea (38%) [39] telithromycin, verapamil, voriconazole
Acral erythema [4] Dyspepsia [2] Pregnancy category: N/A (Can cause fetal
Anaphylactoid reactions/Anaphylaxis [3] Gastrointestinal bleeding [2] harm)
Dermatitis [2] Gastrointestinal disorder [2] Important contra-indications noted in the
Desquamation (7%) Gastrointestinal perforation [3] prescribing guidelines for: nursing mothers;
Edema (21%) [2] Hepatotoxicity [5] pediatric patients
Erythema [6] Nausea (52%) [33]
Exanthems [2] Pancreatitis [4] Skin
Fixed eruption [2] Vomiting [26] Peripheral edema [2]
Folliculitis [2] Respiratory Rash [4]
Hand–foot syndrome [17] Cough [3] Hair
Hypersensitivity (31–45%) [25] Dyspnea (2%) [4] Alopecia (22%)
Lupus erythematosus [5] Pneumonia [5]
Photosensitivity [4] Mucosal
Pneumonitis [4] Epistaxis (nosebleed) (11%) [2]
Pigmentation [3] Pulmonary toxicity [5]
Pruritus [6] Stomatitis (25%)
Pustules [2] Endocrine/Metabolic Central Nervous System
Radiation recall dermatitis [10] ALP increased [2] Fever [2]
Rash (12%) [18] ALT increased [10] Headache [2]
Recall reaction [2] Appetite decreased [4] Peripheral neuropathy (13%)
Scleroderma [6] AST increased [7]
Hyperglycemia [4] Neuromuscular/Skeletal
Toxicity [9] Asthenia (fatigue) (13–41%) [10]
Tumor lysis syndrome [2] SIADH [3]
Urticaria (2–4%) [4] Renal Gastrointestinal/Hepatic
Proteinuria [3] Constipation [2]
Hair Diarrhea (21%) [6]
Alopecia (87100%) [47] Hematologic Nausea (25%) [7]
Nails Anemia (47%) [34] Vomiting (15%) [3]
Leukonychia (Mees’ lines) [2] Bleeding [2]
Febrile neutropenia [19] Respiratory
Nail changes (2%) [6] Dyspnea [2]
Nail pigmentation (2%) [2] Hemotoxicity [10]
Leukopenia (90%) [27] Upper respiratory tract infection (31%)
Onycholysis [9]
Pyogenic granuloma [2] Lymphopenia [2] Endocrine/Metabolic
Myelosuppression [4] Appetite decreased (16%)
Mucosal Myelotoxicity [3]
Epistaxis (nosebleed) [2] Hematologic
Neutropenia (78–98%) [83] Anemia (35%) [9]
Mucosal inflammation [3] Thrombocytopenia (4–20%) [29]
Mucositis (17–35%) [12] Febrile neutropenia [7]
Oral lesions (38%) Ocular Leukopenia (43%) [11]
Stomatitis (239%) [9] Macular edema [10] Lymphopenia [2]
Maculopathy [2] Neutropenia (75%) [21]
Cardiovascular Thrombocytopenia (17%) [6]
Atrial fibrillation [2] Local
Injection-site cellulitis (>10%)
Litt’s Drug Eruption & Reaction Manual PALONOSETRON
Other Skin Genitourinary

Adverse effects [3] Anaphylactoid reactions/Anaphylaxis (<2%) Ejaculatory dysfunction (<2%)
Infection [2] Edema (<2%) Erectile dysfunction [2]
Peripheral edema [4] Sexual dysfunction [3]
Pruritus (<2%) Urinary tract infection (<2%)
PALIFERMIN Rash (<2%) Ocular
Mucosal Vision blurred (3%)
Trade name: Kepivance (Amgen) Nasal congestion (<2%) Local
Indications: Severe oral mucositis in cancer Sialorrhea (<6%) [2] Injection-site pain [9]
patients Tongue edema (3%)
Class: Keratinocyte growth factor Xerostomia (<4%) Other
Half-life: 4.5 hours Adverse effects [7]
Cardiovascular Death [3]
Clinically important, potentially hazardous Arrhythmias (<2%)
interactions with: heparin Atrioventricular block (<2%)
Pregnancy category: C Bradycardia (<2%)
Important contra-indications noted in the Bundle branch block (<3%) PALIVIZUMAB
prescribing guidelines for: nursing mothers Hypertension (<2%)
Palpitation (<2%) [2] Trade name: Synagis (Medimmune)
Skin Tachycardia (<14%) [6] Indications: Prophylaxis of serious lower
Acanthosis nigricans [2] respiratory tract disease caused by respiratory
Central Nervous System syncytial virus in pediatric patients
Edema (28%) [2] Agitation (<2%) [6]
Erythema (32%) [2] Class: Immunomodulator, Monoclonal antibody
Akathisia (3–17%) [22] Half-life: 18 days
Hand–foot syndrome [3] Anxiety (2–9%) [9]
Pruritus (35%) [3] Clinically important, potentially hazardous
Depression [2] interactions with: none known
Rash (62%) [7] Dysarthria (<4%) [2] Pregnancy category: C
Mucosal Extrapyramidal symptoms (4–23%) [15]
Tongue edema (17%) [3] Headache (4–14%) [16]
Tongue pigmentation (17%) Insomnia (<2%) [22] Skin
Neuroleptic malignant syndrome [6] Anaphylactoid reactions/Anaphylaxis [3]
Cardiovascular Rash (26%)
Hypertension (~12%) Nightmares (<2%)
Parkinsonism [4] Central Nervous System
Central Nervous System Psychosis [3] Fever [2]
Dysesthesia (12%) Schizophrenia [6]
Dysgeusia (taste perversion) (16%) [4] Local
Sleep related disorder (2–3%) Injection-site bruising (<3%)
Fever (39%) Somnolence (drowsiness) (6–26%) [13]
Pain (16%) Injection-site edema (<3%)
Tardive dyskinesia [3] Injection-site erythema [3]
Paresthesias (12%) Tremor [7] Injection-site induration (<3%)
Neuromuscular/Skeletal Vertigo (dizziness) (2–6%) [3] Injection-site pain (<9%) [2]
Arthralgia (10%) Neuromuscular/Skeletal Injection-site reactions [2]
Dystonia [6]
PALIPERIDONE Hyperkinesia [2] PALONOSETRON
Rhabdomyolysis [3]
Trade name: Invega (Janssen) Gastrointestinal/Hepatic Trade name: Aloxi (MGI)
Indications: Schizophrenia Abdominal pain (<3%) Indications: Antiemetic (for cancer
Class: Antipsychotic Constipation (4–5%) [3] chemotherapy)
Half-life: ~23 hours Dyspepsia (5–6%) Class: 5-HT3 antagonist, Antiemetic, Serotonin
Clinically important, potentially hazardous Flatulence (<2%) type 3 receptor antagonist
interactions with: ACE inhibitors, alcohol, alpha Nausea [3] Half-life: 40 hours
blockers, amphetamines, angiotensin II receptor Vomiting (3–11%) Clinically important, potentially hazardous
antagonists, carbamazepine, CNS depressants, interactions with: none known
dopamine agonists, droperidol, general Respiratory
Cough (<3%) Pregnancy category: B
anesthetics, itraconazole, levodopa, Note: See also the fixed drug combination
levomepromazine, lithium, methylphenidate, Nasopharyngitis (2–5%) [6]
Pharyngolaryngeal pain (<2%) Netupitant & Palonosetron (separate entry).
metoclopramide, myleosuppressives, P-
glycoprotein inhibitors or inducers, quinagolide, Pulmonary embolism [2]
risperidone, tetrabenazine, valproic acid Rhinitis (<3%) Skin
Pregnancy category: C Endocrine/Metabolic Hot flashes (<15)
Important contra-indications noted in the ALT increased (<2%) Pruritus (822%)
prescribing guidelines for: the elderly; nursing Amenorrhea (6%) [3] Rash (6%)
mothers; pediatric patients Appetite decreased (<2%) Central Nervous System
Note: Invega is not recommended for patients Appetite increased (2–3%) Anorexia [2]
with creatinine clearance below 10 mL/min. AST increased (<2%) Fever [2]
Paliperidone is the active metabolite of Galactorrhea (4%) [5] Headache (9%) [13]
risperidone (see separate entry). Gynecomastia (3%) Vertigo (dizziness) [4]
Warning: INCREASED MORTALITY IN Hyperprolactinemia [10] Neuromuscular/Skeletal
ELDERLY PATIENTS WITH DEMENTIA- Hyponatremia [2] Asthenia (fatigue) [3]
RELATED PSYCHOSIS Menstrual irregularities (<2%) Osteonecrosis (jaw) [13]
Weight gain (2–7%) [19]
PALONOSETRON See all our books at www.crcpress.com
Gastrointestinal/Hepatic Hematologic Pregnancy category: C

Abdominal pain [2] Anemia (43%) Important contra-indications noted in the
Constipation [10] Granulocytopenia (20%) prescribing guidelines for: nursing mothers;
Diarrhea [2] Ocular pediatric patients
Endocrine/Metabolic Conjunctivitis [5] Warning: DERMATOLOGIC TOXICITY and
AST increased [2] Episcleritis [2] INFUSION REACTIONS
Renal Orbital inflammation [2]

Nephrotoxicity [3] Scleritis [4] Skin
Uveitis [12] Acneform eruption (57%) [18]
Other Vision blurred [2] Desquamation [3]
Hiccups [3] Eczema [2]
Local
Injection-site reactions (18%) Erythema (65%) [5]
Exfoliative dermatitis (25%) [2]
PAMIDRONATE Fissures (20%) [4]
Folliculitis [3]
Trade name: Aredia (Novartis) PANCREATIN Hand–foot syndrome [3]
Indications: Hypercalcemia, Paget’s disease, Papulopustular eruption [4]
osteogenesis imperfecta See: www.drugeruptiondata.com/drug/id/1389 Peripheral edema (12%)
Class: Bisphosphonate Pruritus (57%) [9]
Half-life: 1.6 hours Rash (22%) [30]
Clinically important, potentially hazardous PANCRELIPASE Toxicity (90%) [26]
interactions with: none known Xerosis (10%) [12]
Pregnancy category: D See: www.drugeruptiondata.com/drug/id/1180 Hair
Important contra-indications noted in the Alopecia [3]
prescribing guidelines for: nursing mothers; Hair changes (9%) [2]
pediatric patients PANCURONIUM Nails
Nail changes (9–29%) [2]
Skin See: www.drugeruptiondata.com/drug/id/886 Paronychia (25%) [13]
Candidiasis (6%)
Mucosal
Atrial fibrillation (6%) PANDEMIC INFLUENZA Mucositis [4]
Hypertension (6%) Stomatitis (7%) [4]
Tachycardia (6%) VACCINE (H1N1)
Central Nervous System Trade names: Celvapan (Baxter), Focetria Anorexia [3]
Anorexia (26%) (Novartis), Pandemrix (GSK), Tamiflu (Roche) Fever [2]
Fever (18–39%) [8] Indications: Pandemic influenza vaccine (H1N1) Neurotoxicity [2]
Headache (26%) Class: Vaccine
Insomnia (22%) Neuromuscular/Skeletal
Half-life: N/A Asthenia (fatigue) (26%) [15]
Somnolence (drowsiness) (6%) Clinically important, potentially hazardous
Neuromuscular/Skeletal interactions with: none known
Arthralgia (14%) [2] Pregnancy category: C
Asthenia (fatigue) (37%) [2] Note: This is the vaccine for swine flu.
Bone or joint pain [3] Diarrhea (21%) [19]
Fractures [3] Nausea (23%) [8]
Skin Vomiting (19%) [8]
Myalgia/Myopathy [3] Lymphadenopathy (<10%)
Osteonecrosis [19] Respiratory
Central Nervous System Cough (14%)
Gastrointestinal/Hepatic Fever [3]
Abdominal pain (23%) Dyspnea [2]
Guillain–Barré syndrome [2] Pulmonary embolism [3]
Constipation (6%) Headache (>10%)
Dyspepsia (23%) Pulmonary fibrosis [3]
Seizures [2] Pulmonary toxicity [7]
Nausea (54%)
Vomiting (36%) [2] Neuromuscular/Skeletal Endocrine/Metabolic
Asthenia (fatigue) [2] Dehydration [3]
Respiratory
Cough (26%) Other Hypocalcemia [3]
Flu-like syndrome [3] Adverse effects [4] Hypokalemia [6]
Rhinitis (6%) Hypomagnesemia [20]
Sinusitis (16%) Hematologic
Endocrine/Metabolic PANITUMUMAB Anemia [2]
Hypocalcemia [10] Neutropenia [5]
Hypophosphatemia [2] Trade name: Vectibix (Amgen) Thrombocytopenia [3]
Hypothyroidism (6%) Indications: Metastatic colorectal carcinoma Ocular
progression Conjunctivitis (4%) [2]
Genitourinary Class: Antineoplastic, Biologic, Epidermal growth
Azotemia (prerenal) (4%) Corneal perforation [2]
factor receptor (EGFR) inhibitor, Monoclonal Eyelashes – hypertrichosis (6%)
Urinary tract infection (19%) antibody Lacrimation (2%)
Renal Half-life: ~7.5 days Ocular toxicity (15%) [2]
Nephrotoxicity [11] Clinically important, potentially hazardous Trichomegaly [3]
Litt’s Drug Eruption & Reaction Manual PAPAVERINE
Local Nausea (36%) [17] Pregnancy category: B

Infusion-related reactions (3%) [5] Vomiting (26%) [11] Important contra-indications noted in the
Injection-site reactions (4%) Respiratory prescribing guidelines for: nursing mothers
Other Cough (<10%)
Adverse effects [5] Dyspnea (<10%) [5] Skin
Death [2] Pneumonia [5] Anaphylactoid reactions/Anaphylaxis [7]
Infection [3] Respiratory failure (<10%) Edema (<2%)
Wheezing (<10%) Facial edema (<4%)
Endocrine/Metabolic Lupus erythematosus (discoid) [3]
PANOBINOSTAT ALP increased (<10%)
Photosensitivity (<2%)
Appetite decreased (28%) [4]
Trade name: Farydak (Novartis) Creatine phosphokinase increased (41%) [4] Pruritus (<2%)
Indications: Multiple myeloma (in combination Dehydration (<10%) [2] Rash (<2%) [3]
with bortezomib and dexamethasone) Hyperbilirubinemia (21%) [3] Urticaria (<4%) [2]
Class: Histone deacetylase (HDAC) inhibitor Hyperglycemia (<10%) Mucosal
Half-life: 37 hours Hypermagnesemia (27%) Xerostomia (<2%)
Clinically important, potentially hazardous Hyperphosphatemia (29%) Central Nervous System
interactions with: antiarrhythmics, QT Hyperuricemia (<10%) Depression (<2%)
prolonging agents, sensitive CYP2D6 substrates, Hypoalbuminemia (63%) Fever (>4%) [3]
strong CYP3A4 inducers Hypocalcemia (67%) [2] Headache (12%) [2]
Pregnancy category: N/A (can cause fetal harm) Hypokalemia (52%) [7] Vertigo (dizziness) (3%)
Important contra-indications noted in the Hypomagnesemia (<10%)
prescribing guidelines for: the elderly; pediatric Hyponatremia (49%) [2] Neuromuscular/Skeletal
patients Hypophosphatemia (63%) [4] Arthralgia (<4%)
Warning: FATAL AND SERIOUS TOXICITIES: Hypothyroidism (<10%) Myalgia/Myopathy (<4%)
SEVERE DIARRHEA AND CARDIAC Weight loss (12%) [3] Gastrointestinal/Hepatic
TOXICITIES Genitourinary Abdominal pain (6%)
Urinary incontinence (<10%) Constipation (<4%)
Skin Diarrhea (9%)
Renal Flatulence (<4%)
Edema (<10%) Renal failure (<10%)
Erythema (<10%) Hepatitis (<2%)
Lesions (<10%) Hematologic Nausea (7%)
Peripheral edema (29%) [3] Anemia (62%) [13] Pancreatitis [2]
Rash (<10%) [5] Febrile neutropenia [2] Vomiting (4%)
Leukopenia (81%) [5] Respiratory
Mucosal Lymphopenia (82%) [6]
Cheilitis (<10%) Flu-like syndrome (<10%)
Myelosuppression [5] Upper respiratory tract infection (>4%)
Xerostomia (<10%) Neutropenia (75%) [20]
Cardiovascular Sepsis [2] Endocrine/Metabolic
Arrhythmias (12%) Thrombocytopenia (97%) [34] Creatine phosphokinase increased (<2%)
Hypertension (<10%) Hypomagnesemia [3]
Other
Hypotension (<10%) [2] Adverse effects [2] Renal
Orthostatic hypotension (<10%) Death (8%) Nephrotoxicity [4]
Palpitation (<10%) Hematologic
QT prolongation [7] Leukopenia (<2%)
Anorexia [5]
PANTOPRAZOLE Thrombocytopenia (<2%) [5]
Ocular
Chills (<10%) Trade names: Protium (Nycomed), Protonix Vision blurred (<2%)
Dysgeusia (taste perversion) (<10%) [3] (Wyeth)
Fever (26%) [3] Other
Indications: Esophagitis associated with
Headache (<10%) [3] Adverse effects [2]
gastroesophageal reflux disease (GERD),
Insomnia (<10%) Allergic reactions (<4%)
Zollinger-Ellison syndrome, erosive esophagitis
Peripheral neuropathy [8] Infection (<10%)
Class: Proton pump inhibitor (PPI)
Syncope (<10%) [2] Kounis syndrome [2]
Half-life: 1 hour
Tremor (<10%) Clinically important, potentially hazardous
Vertigo (dizziness) (<10%) [2] interactions with: alcohol, allopurinol,
Neuromuscular/Skeletal atazanavir, cefditoren, clopidogrel, conivaptan, PANTOTHENIC ACID
Asthenia (fatigue) (60%) [29] CYP2C19 inducers and substrates, dabigatran,
Back pain [2] dasatinib, delavirdine, dexmethylphenidate, See: www.drugeruptiondata.com/drug/id/529
Joint disorder (<10%) digoxin, erlotinib, eucalyptus, fluconazole,
Gastrointestinal/Hepatic indinavir, iron salts, itraconazole, ketoconazole,
Abdominal distension (<10%) lapatinib, mesalamine, methotrexate, PAPAVERINE
Abdominal pain (<10%) [4] methylphenidate, mycophenolate, nelfinavir,
Colitis (<10%) PEG-interferon, posaconazole, raltegravir, Indications: Peripheral and cerebral ischemia
Constipation [5] rilpivirine, saquinavir, tipranavir, topotecan, Class: Opium alkaloid, Vasodilator, peripheral
Diarrhea (68%) [27] ulipristal, voriconazole, warfarin Half-life: 0.52 hours
Dyspepsia (<10%) [2] Clinically important, potentially hazardous
Flatulence (<10%) interactions with: levodopa, reboxetine
Gastritis (<10%)
PAPAVERINE Over 100 updates per week on www.drugeruptiondata.com
Pregnancy category: C mazindol, methadone, methamphetamine, Constipation (5–18%) [2]

Important contra-indications noted in the methylene blue, methylphenidate, metoprolol, Diarrhea (9–12%) [3]
prescribing guidelines for: nursing mothers; moclobemide, molindone, NSAIDs, Nausea (26%) [6]
pediatric patients perphenazine, phendimetrazine, phenelzine, Vomiting [2]
phenobarbital, phentermine, Respiratory
Cardiovascular phenylpropanolamine, phenytoin, pimozide, Pharyngitis (4%)
Hypotension [2] primidone, procyclidine, propafenone, Rhinitis (3%)
propranolol, pseudoephedrine, ranolazine, Sinusitis (4%)
Genitourinary rasagiline, risperidone, ritonavir, selegiline,
Priapism (11%) [16] sibutramine, St John’s wort, sumatriptan, Endocrine/Metabolic
sympathomimetics, tamoxifen, tamsulosin, Galactorrhea [4]
tetrabenazine, thioridazine, tramadol, Gynecomastia [2]
PARAMETHADIONE tranylcypromine, trazodone, tricyclic Libido decreased (3–15%)
SIADH [18]
antidepressants, troleandomycin, tryptophan,
See: www.drugeruptiondata.com/drug/id/532 valbenazine, vortioxetine Weight gain [8]
Pregnancy category: D Genitourinary
Important contra-indications noted in the Ejaculatory dysfunction (13–28%)
PARICALCITOL prescribing guidelines for: nursing mothers;
pediatric patients
Erectile dysfunction [2]
Priapism [4]
See: www.drugeruptiondata.com/drug/id/943 Note: For menopausal indications see separate Sexual dysfunction [7]
entry for paroxetine mesylate. Otic
Warning: SUICIDALITY AND Hallucinations, auditory [3]
ANTIDEPRESSANT DRUGS
PAROMOMYCIN Ocular
Glaucoma [2]
Trade name: Humatin (Pfizer) Skin Hallucinations, visual [2]
Indications: Intestinal amebiasis Diaphoresis (11%) [10] Vision impaired [2]
Class: Antibiotic, aminoglycoside Ecchymoses [2]
Exanthems [2] Other
Half-life: N/A Adverse effects [2]
Clinically important, potentially hazardous Hyperhidrosis [2]
Photosensitivity [3] Bruxism [4]
interactions with: methotrexate, Congenital malformations [2]
succinylcholine Pruritus [3]
Rash (2%) Death [2]
Pregnancy category: C Infection (5–6%)
Vasculitis [2]
Skin Mucosal
Pruritus [2] Xerostomia (18%) [16]
Cardiovascular
PAROXETINE
Pain [2] Venous thromboembolism [2] MESYLATE
Abnormal dreams (3–4%) Trade name: Brisdelle (Noven)
Abdominal pain [2]
Agitation (3–6%) Indications: Vasomotor symptoms associated
Local Akathisia [3] with the menopause
Injection-site pain [2] Anxiety (5%) [2] Class: Selective serotonin reuptake inhibitor
Chills (2%) [2] (SSRI)
Delirium [3] Half-life: N/A
PAROXETINE HYDRO- Depression [3] Clinically important, potentially hazardous
interactions with: eluxadoline, linezolid, MAO
Dysarthria [2]
CHLORIDE Dysgeusia (taste perversion) (2%) inhibitors, methylene blue, pimozide, tamoxifen,
Extrapyramidal symptoms [2] thioridazine
Trade names: Paxil (GSK), Paxil CR (GSK), Headache (17–28%) [12] Pregnancy category: X
Seroxat (GSK) Insomnia (11–24%) [5] Important contra-indications noted in the
Indications: Depression, obsessive-compulsive Irritability [2] prescribing guidelines for: the elderly; nursing
disorder, panic disorder, social and generalized Mania [2] mothers; pediatric patients
anxiety disorders, post-traumatic stress disorder Nervousness (4–9%) Note: Brisdelle contains a low dose of paroxetine
Class: Antidepressant, Selective serotonin Neuroleptic malignant syndrome [4] and is not indicated for psychiatric conditions.
reuptake inhibitor (SSRI) Paresthesias (4%) Paroxetine mesylate is also available as Pexeva.
Half-life: 21 hours Parkinsonism [3] For psychiatric indications see separate entry for
Clinically important, potentially hazardous Restless legs syndrome [7] paroxetine hydrochloride.
interactions with: alcohol, amitriptyline, Serotonin syndrome [19] Warning: SUICIDAL THOUGHTS AND
amphetamines, antiepileptics, aprepitant, Somnolence (drowsiness) (15–24%) [4] BEHAVIORS
aripiprazole, artemether/lumefantrine, asenapine, Suicidal ideation [4]
aspirin, astemizole, atomoxetine, barbiturates, Tic disorder [3] Central Nervous System
clarithromycin, clozapine, cobicistat/elvitegravir/ Tremor (4–11%) [5] Headache (6%)
emtricitabine/tenofovir alafenamide, cobicistat/ Vertigo (dizziness) (6–14%) [7]
elvitegravir/emtricitabine/tenofovir disoproxil, Neuromuscular/Skeletal
Yawning (2–4%)
coumarins, cyproheptadine, darifenacin, Asthenia (fatigue) (5%)
darunavir, deutetrabenazine, dexibuprofen, Gastrointestinal/Hepatic
dextroamphetamine, diethylpropion, digitalis, Nausea (4%) [2]
digoxin, duloxetine, eluxadoline, entacapone, Vomiting (4%)
erythromycin, galantamine, iloperidone, Gastrointestinal/Hepatic
isocarboxazid, linezolid, lithium, MAO inhibitors, Abdominal pain (4%) [2]
Litt’s Drug Eruption & Reaction Manual PEGAPTANIB
Other hypersensitivity reactions, such as urticaria, Pneumonitis [2]

Adverse effects [2] angioedema, bronchoconstriction, anaphylaxis, Endocrine/Metabolic
Stevens-Johnson syndrome, and toxic epidermal ALT increased [3]
necrolysis to interferon alpha or any other Appetite decreased [2]
product component; or with autoimmune
PASIREOTIDE hepatitis.
AST increased [3]
Diabetes mellitus [2]
See: www.drugeruptiondata.com/drug/id/3135 Warning: RISK OF SERIOUS DISORDERS AND Thyroid dysfunction [2]
RIBAVIRIN-ASSOCIATED EFFECTS Weight loss (16%) [3]
DEPRESSION AND OTHER NEUROPSYCHIA-
Genitourinary
TRIC DISORDERS
PATIROMER Urinary tract infection [2]
Renal
Trade name: Veltassa (Relypsa) Skin Nephrotoxicity [4]
Indications: Hyperkalemia Dermatitis (7%)
Class: Potassium binder Diaphoresis (6%) Hematologic
Half-life: N/A DRESS syndrome [2] Anemia (14%) [44]
Clinically important, potentially hazardous Eczema [2] Hemotoxicity [2]
interactions with: none known Exanthems [5] Leukopenia [6]
Pregnancy category: N/A (Not expected to Fixed eruption [2] Lymphopenia (14%) [2]
cause fetal risk) Lupus erythematosus [3] Neutropenia (21%) [20]
Important contra-indications noted in the Nummular eczema [2] Sepsis [2]
prescribing guidelines for: pediatric patients Photosensitivity [4] Thrombocytopenia (5%) [15]
Warning: BINDING TO OTHER ORAL Pruritus (12%) [11] Otic
MEDICATIONS Psoriasis [4] Hearing loss [2]
Rash (6%) [24] Tinnitus [2]
Gastrointestinal/Hepatic Rosacea fulminans [2] Ocular
Abdominal pain (2%) Sarcoidosis [9] Retinopathy [7]
Constipation (7%) [11] Stevens-Johnson syndrome [2] Vision blurred (4%)
Diarrhea (5%) [5] Toxic epidermal necrolysis [2]
Toxicity [3] Local
Flatulence (2%) [3] Injection-site pain (2%)
Nausea (2%) [2] Vasculitis [2]
Vitiligo [3] Injection-site reactions (22%) [4]
Vomiting (<2%) [3]
Xerosis (11%) [2] Other
Endocrine/Metabolic Adverse effects [26]
Hypokalemia (5%) [5] Hair
Alopecia (22%) [5] Death [2]
Hypomagnesemia (5–9%) [6] Infection (3%) [4]
Alopecia areata [2]
Cardiovascular
Flushing (6%)
PAZOPANIB PEGAPTANIB
See: www.drugeruptiondata.com/drug/id/1430 Anorexia (17%) [2] Trade name: Macugen (Valeant)
Chills [2] Indications: Neovascular (wet) age-related
Cognitive impairment [2] macular degeneration
PEG-INTERFERON Depression (1629%) [10] Class: Vascular endothelial growth factor
Dysgeusia (taste perversion) (<10%) [5] antagonist
Trade names: PegIntron (Schering), Sylatron Fever (37%) [8] Half-life: 10±4 days
(Schering) Headache (54%) [16] Clinically important, potentially hazardous
Indications: Chronic hepatitis C, melanoma Insomnia (19%) [4] interactions with: none known
Class: Immunomodulator, Interferon Irritability [2] Pregnancy category: B
Half-life: ~40 hours Neurotoxicity [2] Important contra-indications noted in the
Clinically important, potentially hazardous Pain (12%) prescribing guidelines for: nursing mothers;
interactions with: ACE inhibitors, Parkinsonism [2] pediatric patients
acetaminophen, aldesleukin, bupivacaine, Psychosis [2] Note: Contra-indicated in patients with ocular or
cilostazol, cinacalcet, CYP2C9 substrates, Vertigo (dizziness) (16%) [3] periocular infections.
CYP2D6 substrates, delavirdine, duloxetine, Neuromuscular/Skeletal
estradiol, fesoterodine, fingolimod, fluoxetine, Arthralgia (28%) [2] Skin
indinavir, melphalan, methadone, Asthenia (fatigue) (56%) [24] Dermatitis (<5%)
methylnaltrexone, pantoprazole, pegloticase, Back pain (9%)
ribavirin, sildenafil, tapentadol, telbivudine, Myalgia/Myopathy (3842%) [4] Cardiovascular
theophylline, theophylline derivatives, tiotropium, Arterial occlusion (carotid) (<5%)
Gastrointestinal/Hepatic Chest pain (<5%)
trimethoprim, voriconazole, warfarin, zidovudine Abdominal pain (15%)
Pregnancy category: C (pregnancy category Hypertension (10–40%)
Diarrhea (16%) [4] Myocardial ischemia (transient) (<5%)
will be X when used in combination with Hepatotoxicity [5]
ribavirin) Nausea (24%) [12] Central Nervous System
Important contra-indications noted in the Pancreatitis [4] Cerebrovascular accident (<5%)
prescribing guidelines for: nursing mothers; Vomiting (24%) [2] Headache (6–10%)
pediatric patients Ischemic injury (transient) (<5%)
Note: PEG-interferon is commonly administered Respiratory Vertigo (dizziness) (<10%)
with ribavirin and many of the reactions listed Cough (6%)
Dyspnea (13%) [2] Neuromuscular/Skeletal
below are in combination therapy with this drug.
Flu-like syndrome (46%) [11] Arthralgia (<5%)
Contra-indicated in patients with known
PEGAPTANIB See all our books at www.crcpress.com
Gastrointestinal/Hepatic Fever (>5%) Other

Diarrhea (6–10%) Headache (<5%) Adverse effects [2]
Nausea (6–10%) Paresthesias (<5%)
Vomiting (<5%) Seizures (<5%) [2]
Respiratory Neuromuscular/Skeletal PEGVISOMANT
Bronchitis (6–10%) Arthralgia (<5%)
Pleural effusion (<5%) Myalgia/Myopathy (<5%) Trade name: Somavert (Pfizer)
Endocrine/Metabolic Gastrointestinal/Hepatic Indications: Acromegaly
Diabetes mellitus (<5%) Abdominal pain (<5%) Class: Growth hormone analog
Hepatotoxicity [3] Half-life: 6 days
Urinary retention (<5%) Pancreatitis [3]
interactions with: acarbose, exenatide,
Urinary tract infection (6–10%) Hematologic hydromorphone, insulin, latex, metformin,
Otic Leukopenia [2] opioids, oral hypoglycemics, pioglitazone,
Hearing loss (<5%) Neutropenia [2] saxagliptin, tapentadol
Otitis media (<5%) Thrombocytopenia [2] Pregnancy category: B
Ocular Other Important contra-indications noted in the
Blepharitis (6–10%) Allergic reactions (>5%) [6] prescribing guidelines for: the elderly; nursing
Cataract (10–40%) [2]
Conjunctival edema (<5%)
Conjunctival hemorrhage (10–40%) PEGINESATIDE Skin
Conjunctivitis (<10%) Lipohypertrophy (<5%) [2]
Corneal abnormalities (<5%) See: www.drugeruptiondata.com/drug/id/2887 Peripheral edema (48%)
Corneal deposits (<5%) Cardiovascular
Corneal edema (10–40%) Chest pain (4–8%)
Endophthalmitis (<5%) [4]
Eyelid irritation (<5%)
PEGLOTICASE Hypertension (8%)
Intraocular pressure increased (10–40%) Central Nervous System
Trade name: Krystexxa (Savient) Pain (4–14%)
Meibomianitis (<5%) Indications: Chronic gout
Mydriasis (<5%) Paresthesias (7%)
Class: Enzyme Vertigo (dizziness) (4–8%)
Ocular edema (<5%) Half-life: N/A
Ocular hypertension (10–40%) Clinically important, potentially hazardous Neuromuscular/Skeletal
Ocular inflammation (<5%) [2] interactions with: PEG-interferon Back pain (4–8%)
Ocular pain (10–40%) Pregnancy category: C Gastrointestinal/Hepatic
Ocular stinging (10–40%) Important contra-indications noted in the Diarrhea (4–14%)
Ophthalmitis (<5%) prescribing guidelines for: nursing mothers; Hepatitis [2]
Periorbital hematoma (<5%) pediatric patients Hepatotoxicity [6]
Photopsia (6–10%) Note: Contra-indicated for patients at higher risk Nausea (8–14%)
Punctate keratitis (10–40%) for G6PD deficiency (e.g. those of African and
Reduced visual acuity (10–40%) Respiratory
Mediterranean ancestry) who should be screened
Retinal detachment (<10%) [5] Flu-like syndrome (4–12%)
due to the risk of hemolysis and
Retinal edema (<5%) Sinusitis (4–8%)
methemoglobinemia.
Vision blurred (10–40%) Warning: ANAPHYLAXIS and INFUSION Local
Visual disturbances (10–40%) REACTIONS Injection-site reactions (8–11%) [4]
Vitreous floaters (10–40%) Other
Anaphylactoid reactions/Anaphylaxis (5%) Infection (23%)
PEGASPARGASE [3]
Ecchymoses (11%)
Trade name: Oncaspar (Enzon)
Indications: Acute lymphoblastic leukemia Cardiovascular PEMBROLIZUMAB
Class: Antineoplastic Chest pain (6%)
Synonym: lambrolizumab
Half-life: 5.7 days Central Nervous System Trade name: Keytruda (Merck Sharpe &
Clinically important, potentially hazardous Vertigo (dizziness) [3] Dohme)
interactions with: none known Neuromuscular/Skeletal Indications: Unresectable or metastatic
Pregnancy category: C Arthralgia [3] melanoma and disease progression following
Back pain [2] ipilimumab and, if BRAF V600 mutation positive, a
Skin Gouty tophi (flare) (77%) [7] BRAF inhibitor
Anaphylactoid reactions/Anaphylaxis (<5%) Gastrointestinal/Hepatic Class: Monoclonal antibody, Programmed death
[2] Constipation (6%) receptor-1 (PD-1) inhibitor
Angioedema (<5%) Nausea (12%) [3] Half-life: 26 days
Edema (>5%) Vomiting (5%) Clinically important, potentially hazardous
Rash (<5%) interactions with: none known
Urticaria (<5%) Respiratory Pregnancy category: D
Dyspnea [2] Important contra-indications noted in the
Cardiovascular Nasopharyngitis (7%)
Hypotension (>5%) prescribing guidelines for: nursing mothers;
Tachycardia (>5%) Local pediatric patients
Infusion-related reactions [4]
Central Nervous System Infusion-site reactions (26%) [4]
Chills (<5%)
Litt’s Drug Eruption & Reaction Manual PENBUTOLOL
Skin Hematologic Neuromuscular/Skeletal

Bullous pemphigoid [4] Anemia (14–55%) [6] Asthenia (fatigue) (25–34%) [34]
Dermatitis [2] Neutropenia [3] Gastrointestinal/Hepatic
Exanthems [3] Sepsis (<10%) [2] Abdominal pain (<5%)
Lichen planus [2] Thrombocytopenia [4] Constipation (<6%) [4]
Lichenoid eruption [3] Ocular Diarrhea (5–13%) [13]
Peripheral edema (17%) Iridocyclitis [2] Hepatotoxicity [7]
Pruritus (30%) [15] Uveitis [5] Nausea (19–31%) [17]
Psoriasis [3] Vomiting (9–16%) [10]
Rash (29%) [14] Local
Sarcoidosis [4] Infusion-related reactions [2] Respiratory
Scleroderma [2] Other Cough [2]
Toxicity [5] Adverse effects [17] Dysphonia [2]
Vasculitis [2] Death [6] Dyspnea [4]
Vitiligo (11%) [9] Side effects [3] Hemoptysis [2]
Pharyngitis (15%)
Hair Pulmonary toxicity [2]
Alopecia [2]
PEMETREXED Endocrine/Metabolic
Central Nervous System ALT increased (8–10%) [3]
Chills (14%) Appetite decreased [5]
Encephalopathy [3] Trade name: Alimta (Lilly)
Indications: Non-squamous non-small cell lung AST increased (7–8%) [3]
Fever (11%) [5] Creatine phosphokinase increased (<5%)
Headache (16%) [3] cancer, mesothelioma (in combination with
cisplatin) [3]
Insomnia (14%) Hyperglycemia [2]
Neurotoxicity [3] Class: Antimetabolite, Folic acid antagonist
Half-life: 3.5 hours Hyperkalemia [2]
Peripheral neuropathy [2] Hypokalemia [2]
Vertigo (dizziness) (11%) Clinically important, potentially hazardous
interactions with: clozapine, digoxin, Hypomagnesemia [3]
Neuromuscular/Skeletal leflunomide, meloxicam, natalizumab, Hyponatremia [3]
Arthralgia (20%) [8] nephrotoxic drugs, NSAIDs, phenytoin, Renal
Asthenia (fatigue) (47%) [20] pimecrolimus, probenecid, pyrimethamine, Nephrotoxicity [3]
Back pain (12%) sipuleucel-T, tacrolimus, trastuzumab, vaccines
Myalgia/Myopathy (14%) [6] Hematologic
Pregnancy category: D Anemia (15–19%) [22]
Myasthenia gravis [5] Important contra-indications noted in the
Pain in extremities (18%) Febrile neutropenia (<5%) [10]
prescribing guidelines for: nursing mothers; Hemotoxicity [3]
Gastrointestinal/Hepatic pediatric patients Leukocytopenia [2]
Abdominal pain (12%) [2] Leukopenia (6–12%) [11]
Colitis [11] Skin Lymphocytopenia [2]
Constipation (21%) AGEP [4] Myelosuppression [3]
Diarrhea (20%) [11] Cellulitis [3] Neutropenia (6–11%) [22]
Hepatitis [5] Desquamation (10–14%) Sepsis [2]
Hepatotoxicity [6] Edema (<5%) Thrombocytopenia (<8%) [14]
Nausea (30%) [9] Erythema multiforme (<5%) Thrombotic complications [2]
Pancreatitis [6] Hypersensitivity (<5%)
Vomiting (16%) [3] Ocular
Peripheral edema [4] Conjunctivitis (<5%)
Respiratory Pruritus (<7%) Eyelid edema [3]
Cough (30%) [5] Radiation recall dermatitis [7] Lacrimation (<5%)
Dyspnea (18%) [4] Rash (10–14%) [20]
Pneumonia [4] Toxic epidermal necrolysis [5] Other
Pneumonitis (3%) [15] Toxicity [2] Adverse effects (53%) [14]
Upper respiratory tract infection (11%) Urticaria [3] Allergic reactions (<5%)
Vasculitis [2] Death [5]
Endocrine/Metabolic Hiccups [2]
ALT increased [4] Hair Infection (<5%) [7]
Appetite decreased (26%) [7] Alopecia (<6%) [5]
AST increased (24%) [4] Mucosal
Diabetes mellitus [5] Epistaxis (nosebleed) [2]
Hyperglycemia (40%) Mucositis (7%) [6]
PEMIROLAST
Hyperthyroidism [5] Stomatitis (7–15%) [6]
Hypertriglyceridemia (25%) See: www.drugeruptiondata.com/drug/id/887
Hypoalbuminemia (34%) Cardiovascular
Hypocalcemia (24%) Hypertension [6]
Hyponatremia (35%) [2] Venous thromboembolism [2] PEMOLINE
Hypophysitis [7] Central Nervous System
Hypothyroidism (8%) [13] Anorexia (19–22%) [8] See: www.drugeruptiondata.com/drug/id/534
Thyroid dysfunction [5] Depression (14%)
Thyroiditis [4] Dysgeusia (taste perversion) [2]
Renal Fever (<8%) [2]
Headache [4]
PENBUTOLOL
Nephrotoxicity [5]
Renal failure [3] Insomnia [2] See: www.drugeruptiondata.com/drug/id/535
Neurotoxicity (<9%)
Peripheral neuropathy [2]
PENCICLOVIR Over 100 updates per week on www.drugeruptiondata.com
Nails
PENCICLOVIR Nail pigmentation [4] PENICILLIN V
See: www.drugeruptiondata.com/drug/id/1178 Mucosal Trade name: V-cillin K (Lilly)
Aphthous stomatitis [2] Indications: Cellulitis, endocarditis, erysipelas,
Mucosal lesions (pemphigus-like) [2] oral infections, otitis media, rheumatic fever,
Oral ulceration [5]
PENICILLAMINE Stomatitis [6]
scarlet fever, tonsillitis
Class: Antibiotic, penicillin
Trade name: Depen (MedPointe) Central Nervous System Half-life: 4 hours
Indications: Wilson’s disease, rheumatoid Ageusia (taste loss) (12%) [2] Clinically important, potentially hazardous
arthritis Dysgeusia (taste perversion) (metallic taste) interactions with: estrogens, methotrexate,
Class: Antidote, Chelator, Disease-modifying [8] minocycline, neomycin, phenindione, probenecid,
antirheumatic drug (DMARD) Hypogeusia (2533%) [2] sulfinpyrazone, warfarin
Half-life: 1.73.2 hours Neuromuscular/Skeletal Pregnancy category: B
Clinically important, potentially hazardous Dystonia [4]
interactions with: aluminum, antacids, ascorbic Myasthenia gravis [73] Skin
acid, bone marrow suppressants, chloroquine, Polymyositis [8] Anaphylactoid reactions/Anaphylaxis [2]
clozapine, cytotoxic agents, diclofenac, ferrous Respiratory DRESS syndrome [2]
sulfate, food, gold & gold compounds, Pulmonary toxicity [2] Hypersensitivity [3]
hydroxychloroquine, iron, magnesium, Serum sickness [2]
meloxicam, primaquine, probenecid, sodium Endocrine/Metabolic Serum sickness-like reaction [2]
picosulfate Gynecomastia [5] Urticaria [3]
Pregnancy category: D Renal Central Nervous System
Important contra-indications noted in the Glomerulonephritis [3] Fever [3]
prescribing guidelines for: nursing mothers; Nephrotoxicity [5]
pediatric patients Proteinuria [2] Neuromuscular/Skeletal
Note: As an antidote, it is difficult to differentiate Arthralgia [2]
Hematologic
side effects due to the drug from those due to the
Hemotoxicity [2] Gastrointestinal/Hepatic
effects of the poison. Diarrhea [2]
Other
Adverse effects [2]
Skin
Bullous dermatitis [3] PENTAGASTRIN
Bullous pemphigoid [6]
Cicatricial pemphigoid [2] PENICILLIN G See: www.drugeruptiondata.com/drug/id/538
Cutis laxa [13]
Dermatitis [4] Trade name: Crystapen (Britannia)
Dermatomyositis [14] Indications: Anthrax, cellulitis, endocarditis,
Edema of lip (<10%) infections, otitis media, rheumatic fever, PENTAMIDINE
Ehlers–Danlos syndrome [2] respiratory infections, septicemia
Class: Antibiotic, penicillin Trade names: NebuPent (Astellas), Pentacarinat
Elastosis perforans serpiginosa [43] (Sanofi-Aventis), Pentam 300 (Astellas)
Epidermolysis bullosa [4] Half-life: 4 hours
Clinically important, potentially hazardous Indications: Pneumocystis jiroveci infection,
Epidermolysis bullosa acquisita [2] trypanosomiasis, leishmaniasis
Erythema multiforme (<5%) interactions with: estrogens, methotrexate,
minocycline, phenindione, probenecid, Class: Antiprotozoal
Exanthems [8] Half-life: 9.1–13.2 hours (intramuscular); 6.5
Fragility [2] sulfinpyrazone, warfarin
Pregnancy category: B hours (intravenous)
Hypersensitivity [3] Clinically important, potentially hazardous
Lichen planus [4] Important contra-indications noted in the
prescribing guidelines for: nursing mothers interactions with: adefovir, aminoglycosides,
Lichenoid eruption [7] amiodarone, amisulpride, amitriptyline,
Lupus erythematosus [43] amphotericin B, cisplatin, droperidol,
Morphea [2] Skin erythromycin, foscarnet, insulin aspart, insulin
Pemphigus [75] Anaphylactoid reactions/Anaphylaxis [5] degludec, insulin detemir, insulin glargine, insulin
Pemphigus erythematodes (SenearUsher) Dermatitis [2] glulisine, ivabradine, levomepromazine,
[10] Hypersensitivity [4] moxifloxacin, phenothiazines, saquinavir,
Pemphigus foliaceus [16] Jarisch–Herxheimer reaction [21] sparfloxacin, sulpiride, tricyclic antidepressants,
Pemphigus herpetiformis [3] Nicolau syndrome [2] trifluoperazine, vancomycin
Pemphigus vulgaris [2] Rash [4] Pregnancy category: C
Peripheral edema (<10%) Serum sickness-like reaction [2] Important contra-indications noted in the
Pruritus (4450%) [2] prescribing guidelines for: nursing mothers;
Pseudoxanthoma elasticum [16] pediatric patients
Hoigne’s syndrome [16]
Psoriasis [4] Note: The rate of adverse side effects is
Seizures [2]
Purpura [5] increased in patients with AIDS.
Rash (4450%) [6] Gastrointestinal/Hepatic
Scleroderma [7] Hepatotoxicity [2]
Toxic epidermal necrolysis [2] Genitourinary Skin
Urticaria (4450%) [2] Exanthems (<15%) [10]
Cystitis [3]
Vasculitis [7] Pruritus [2]
Renal Rash (<47%) [4]
Hair Nephrotoxicity [2] Toxic epidermal necrolysis [3]
Alopecia [3] Urticaria [3]
Hirsutism [2]
Hematologic
Thrombosis [2]
Litt’s Drug Eruption & Reaction Manual PERICYAZINE
Cardiovascular Confusion (<2%)

QT prolongation [8] PEPLOMYCIN Depression [2]
Torsades de pointes [4] Dysarthria (<4%)
See: www.drugeruptiondata.com/drug/id/1129 Euphoria (<2%)
Dysgeusia (taste perversion) (metallic taste) Gait instability (<4%) [11]
(2%) Headache (11–13%) [15]
Paresthesias [2] PERAMIVIR Hypersomnia (<3%)
Vertigo (dizziness) [2] Hypoesthesia (<3%)
Trade name: Rapivab (BioCryst) Incoordination (<2%)
Neuromuscular/Skeletal Indications: Influenza Irritability (4–12%) [16]
Myalgia/Myopathy (<5%) Class: Antiviral, Neuraminidase inhibitor Memory loss (<2%)
Rhabdomyolysis [4] Half-life: ~20 hours Mood changes (<2%)
Gastrointestinal/Hepatic Clinically important, potentially hazardous Neurotoxicity [2]
Pancreatitis [6] interactions with: live attenuated influenza Paresthesias (<2%)
vaccine Sedation [2]
Local
Pregnancy category: C Seizures [3]
Injection-site irritation [2]
Important contra-indications noted in the Somnolence (drowsiness) (9–18%) [27]
prescribing guidelines for: nursing mothers; Suicidal ideation [3]
Injection-site reactions (>10%)
pediatric patients Vertigo (dizziness) (16–43%) [32]
Other
Adverse effects [4]
Cardiovascular Arthralgia (<3%)
Hypertension (2%) Asthenia (fatigue) (<12%) [18]
Central Nervous System Ataxia (<8%) [6]
PENTAZOCINE Behavioral disturbances [2] Back pain (2–5%)
Insomnia (3%) Bone or joint pain (<2%)
See: www.drugeruptiondata.com/drug/id/540 Myalgia/Myopathy (<3%)
Gastrointestinal/Hepatic Pain in extremities (<3%)
Constipation (4%)
Diarrhea (8%) [6] Gastrointestinal/Hepatic
PENTOBARBITAL Nausea [4] Constipation (2–3%)
Vomiting [4] Nausea (3–8%) [6]
See: www.drugeruptiondata.com/drug/id/541 Vomiting (2–4%) [2]
Endocrine/Metabolic
ALT increased (3%) Respiratory
AST increased (3%) Cough (<4%)
PENTOSAN Creatine phosphokinase increased (4%) Nasopharyngitis [2]
Hyperglycemia (5%) Upper respiratory tract infection (3–4%)
Hematologic Endocrine/Metabolic
Neutropenia (8%) [4] Hyponatremia (<2%)
Weight gain (4%) [8]
PENTOSTATIN Thrombocytopenia [2]
Ocular
See: www.drugeruptiondata.com/drug/id/543 Diplopia (<3%)
PERAMPANEL
Other
PENTOXIFYLLINE Trade name: Fycompa (Eisai) Adverse effects [6]
Indications: Partial-onset seizures, primary
Trade names: Pentoxil (Upsher-Smith), Trental generalized tonic-clonic seizures
(Sanofi-Aventis) Class: AMPA glutamate receptor antagonist,
Anticonvulsant, Antiepileptic
PERFLUTREN
Indications: Peripheral vascular disease,
intermittent claudication Half-life: ~105 hours See: www.drugeruptiondata.com/drug/id/1057
Class: Vasodilator, peripheral, Xanthine alkaloid Clinically important, potentially hazardous
Half-life: 0.40.8 hours interactions with: alcohol, carbamazepine, oral
contraceptives, oxcarbazepine, phenobarbital,
interactions with: abciximab, benazepril, phenytoin, primidone, rifampin, St John’s wort PERGOLIDE
captopril, ceftobiprole, cilostazol, ciprofloxacin, Pregnancy category: C
Important contra-indications noted in the See: www.drugeruptiondata.com/drug/id/545
citalopram, clevidipine, clopidogrel, diclofenac,
enalapril, eptifibatide, fosinopril, insulin degludec, prescribing guidelines for: the elderly; nursing
insulin glargine, insulin glulisine, irbesartan, mothers; pediatric patients
lisinopril, meloxicam, olmesartan, quinapril, Warning: SERIOUS PSYCHIATRIC AND PERICYAZINE
ramipril, tinzaparin BEHAVIORAL REACTIONS
Pregnancy category: C See: www.drugeruptiondata.com/drug/id/1411
Skin
Mucosal Peripheral edema (<2%)
Xerostomia [2] Mucosal
Cardiovascular Oropharyngeal pain (2%)
Flushing (2%) [2] Central Nervous System
Aggression (<3%) [11]
Anxiety (2–4%)
Balance disorder (<5%)
Behavioral disturbances [4]
PERINDOPRIL See all our books at www.crcpress.com
Neuromuscular/Skeletal midazolam, mifepristone, nilotinib, ombitasvir/

PERINDOPRIL Rhabdomyolysis [2] paritaprevir/ritonavir, oxcarbazepine,
Endocrine/Metabolic oxtriphylline, paroxetine hydrochloride,
Trade names: Aceon (Solvay), Prestalia perampanel, piracetam, pizotifen, prednisolone,
(Symplmed) Mastodynia (<10%)
prednisone, propranolol, ranolazine, regorafenib,
Indications: Hypertension, coronary disease Genitourinary rilpivirine, riociguat, rivaroxaban, roflumilast,
Class: Angiotensin-converting enzyme (ACE) Priapism [2] romidepsin, rufinamide, simeprevir, sodium
inhibitor, Antihypertensive oxybate, sofosbuvir, sofosbuvir & velpatasvir,
Half-life: 1.53 hours sofosbuvir/velpatasvir/voxilaprevir, solifenacin,
PERTUZUMAB sonidegib, sorafenib, sunitinib, telaprevir,
telithromycin, temsirolimus, teniposide, tenofovir
Pregnancy category: D (category C in first See: www.drugeruptiondata.com/drug/id/2937 alafenamide, tiagabine, ticagrelor, tipranavir,
trimester; category D in second and third trabectedin, triamcinolone, ulipristal, vandetanib,
trimesters) vemurafenib, voriconazole, warfarin
Important contra-indications noted in the Pregnancy category: D
prescribing guidelines for: nursing mothers; PHENACEMIDE Important contra-indications noted in the
pediatric patients prescribing guidelines for: the elderly; nursing
Note: Prestalia is perindopril and amlodipine. See: www.drugeruptiondata.com/drug/id/1981
mothers
Warning: FETAL TOXICITY Note: Aromatic antiepileptic drugs, phenytoin,
phenobarbital, carbamazepine and primidone, are
Skin PHENAZOPYRIDINE a frequent cause of severe cutaneous adverse
Angioedema [6] reactions. A strong genetic association between
Edema (4%) See: www.drugeruptiondata.com/drug/id/548 HLA-B*1502 and phenobarbital-induced Stevens-
Peripheral edema [3] Johnson syndrome and toxic epidermal necrolysis
Pruritus (<10%) has been shown in Han Chinese patients.
Rash (<10%) PHENDIMETRAZINE
Mucosal Skin
Tongue edema [2] See: www.drugeruptiondata.com/drug/id/549 Anticonvulsant hypersensitivity syndrome
Central Nervous System [10]
Paresthesias (2%) Bullous dermatitis [5]
Vertigo (dizziness) [2] PHENELZINE DRESS syndrome [13]
Neuromuscular/Skeletal See: www.drugeruptiondata.com/drug/id/550 Erythroderma [2]
Back pain (6%) Exanthems [13]
Respiratory Exfoliative dermatitis [6]
Fixed eruption [9]
Cough (12%) [16] PHENINDAMINE Hypersensitivity [12]
Other
Adverse effects [2]
Purpura [2]
Rash [4]
PERMETHRIN PHENOBARBITAL Toxic epidermal necrolysis [26]
Synonyms: phenobarbitone;
Nails
phenylethylmalonylurea Nail hypoplasia [2]
Trade name: Luminal (Sanofi-Aventis) Mucosal
Indications: Insomnia, seizures Gingival hyperplasia/hypertrophy [4]
PERPHENAZINE Class: Anticonvulsant, Barbiturate, CYP3A4 Central Nervous System
Trade names: Decentan (Merck), Fentazin inducer Behavioral disturbances [3]
(Goldshield), Trilafon (Schering) Half-life: 26 days Somnolence (drowsiness) [2]
Indications: Psychotic disorders, nausea and Clinically important, potentially hazardous Vertigo (dizziness) [2]
vomiting interactions with: abacavir, abiraterone, afatinib,
alcohol, amprenavir, anticoagulants, Neuromuscular/Skeletal
Class: Antiemetic, Antipsychotic, Phenothiazine Asthenia (fatigue) [2]
Half-life: 9 hours antihistamines, apremilast, aprepitant,
betamethasone, boceprevir, brompheniramine, Hypoplasia of phalanges [2]
interactions with: cobicistat/elvitegravir/ buclizine, buprenorphine, cabazitaxel, Gastrointestinal/Hepatic
emtricitabine/tenofovir alafenamide, cobicistat/ cabozantinib, caffeine, calcifediol, Hepatotoxicity [2]
elvitegravir/emtricitabine/tenofovir disoproxil, chlorpheniramine, cobicistat/elvitegravir/ Local
paroxetine hydrochloride, sparfloxacin emtricitabine/tenofovir disoproxil, crizotinib, Injection-site pain (>10%)
Pregnancy category: C darunavir, dasabuvir/ombitasvir/paritaprevir/ Injection-site thrombophlebitis (>10%)
Note: Perphenazine is also used in combination ritonavir, dasatinib, deferasirox, delavirdine,
dexamethasone, dicumarol, doxercalciferol, Other
with amitriptyline. Allergic reactions [2]
dronedarone, eliglustat, emtricitabine/rilpivirine/
tenofovir alafenamide, enzalutamide, estradiol, Death [2]
Skin ethanolamine, ethosuximide, etravirine, Side effects [2]
Exanthems [2] fesoterodine, flibanserin, fluconazole, flunisolide, Teratogenicity [5]
Lupus erythematosus [4] fosamprenavir, gefitinib, hydrocortisone, imatinib,
Rash (<10%) indinavir, influenza vaccine, itraconazole,
Central Nervous System ixabepilone, lacosamide, lapatinib, ledipasvir & PHENOLPHTHALEIN
Tardive dyskinesia [2] sofosbuvir, lisdexamfetamine, lopinavir,
meperidine, methsuximide, methylprednisolone, See: www.drugeruptiondata.com/drug/id/553
Litt’s Drug Eruption & Reaction Manual PHENYTOIN
PHENOXY-BENZAMINE Important contra-indications noted in the PHENYTOIN
See: www.drugeruptiondata.com/drug/id/554 Synonyms: diphenylhydantoin; DPH; phenytoin
sodium
Cardiovascular Trade name: Dilantin (Pfizer)
Flushing (<10%) [2]
PHENSUXIMIDE Central Nervous System
Indications: Grand mal seizures
Class: Antiarrhythmic class Ib, Anticonvulsant,
See: www.drugeruptiondata.com/drug/id/555 Headache [2] Antiepileptic, hydantoin, CYP3A4 inducer
Genitourinary Half-life: 742 hours (dose dependent)
Priapism [4] Clinically important, potentially hazardous
interactions with: abacavir, abiraterone,
PHENTERMINE acitretin, afatinib, amiodarone, amitriptyline,
amlodipine, amprenavir, apixaban, apremilast,
Trade names: Adipex-P (Teva), Ionamin PHENYLBUTAZONE aprepitant, artemether/lumefantrine,
(Celltech), Lomaira (Avanthi), Qsymia (Vivus) beclomethasone, boceprevir, brigatinib,
Indications: Obesity See: www.drugeruptiondata.com/drug/id/1257 brivaracetam, buprenorphine, cabazitaxel,
Class: Amphetamine cabozantinib, caffeine, calcium, capecitabine,
Half-life: 1924 hours caspofungin, cefazolin, ceritinib, chloramphenicol,
interactions with: fluoxetine, fluvoxamine,
PHENYLEPHRINE cimetidine, ciprofloxacin, citalopram, clobazam,
clorazepate, cobicistat/elvitegravir/emtricitabine/
MAO inhibitors, paroxetine hydrochloride, Trade names: Rynatan (MedPointe), Tussi-12D tenofovir disoproxil, cobimetinib, colesevelam,
phenelzine, sertraline, tranylcypromine (MedPointe) copanlisib, crizotinib, cyclosporine, cyproterone,
Pregnancy category: X Indications: Nasal congestion, glaucoma, dabigatran, daclatasvir, darunavir, dasabuvir/
Important contra-indications noted in the hypotension ombitasvir/paritaprevir/ritonavir, dasatinib,
prescribing guidelines for: the elderly; nursing Class: Adrenergic alpha-receptor agonist, deferasirox, deflazacort, delavirdine,
mothers; pediatric patients Sympathomimetic dexamethasone, diazoxide, disulfiram, dopamine,
Note: Qsymia is phentermine and topiramate. Half-life: 2.5 hours doxycycline, dronedarone, efavirenz, elbasvir &
Clinically important, potentially hazardous grazoprevir, eliglustat, emtricitabine/rilpivirine/
Mucosal interactions with: epinephrine, furazolidone, tenofovir alafenamide, enzalutamide, erlotinib,
Xerostomia [6] iobenguane, MAO inhibitors, oxprenolol, eslicarbazepine, ethosuximide, etravirine,
Cardiovascular phenelzine, tranylcypromine everolimus, ezogabine, fesoterodine, flibanserin,
Cardiotoxicity [3] Pregnancy category: C floxuridine, fluconazole, flunisolide, fluoxetine,
Hypertension [11] Important contra-indications noted in the fosamprenavir, gefitinib, gold & gold compounds,
Palpitation [3] prescribing guidelines for: nursing mothers; hydrocortisone, ibrutinib, idelalisib, imatinib,
Tachycardia [4] pediatric patients indinavir, influenza vaccine, isoniazid, isotretinoin,
Valvulopathy [17] isradipine, itraconazole, ixabepilone, ixazomib,
Skin lacosamide, lapatinib, ledipasvir & sofosbuvir,
Central Nervous System leflunomide, levodopa, levomepromazine,
Anxiety [2] Dermatitis [16]
Hypersensitivity [2] levonorgestrel, lisdexamfetamine, lomustine,
Cognitive impairment [4] lopinavir, meperidine, metformin, methsuximide,
Depression [3] Stinging (from nasal or ophthalmic
preparations) (<10%) methylprednisolone, metronidazole, midazolam,
Dysgeusia (taste perversion) [4] midostaurin, mifepristone, mivacurium,
Headache [2] Cardiovascular naldemedine, nelfinavir, neratinib, nifedipine,
Insomnia [7] Bradycardia [3] nilotinib, nilutamide, nintedanib, olaparib,
Paresthesias [6] Hypertension [2] ombitasvir/paritaprevir/ritonavir, omeprazole,
Vertigo (dizziness) [4] Ocular ondansetron, osimertinib, oxcarbazepine,
Gastrointestinal/Hepatic Blepharoconjunctivitis [4] oxtriphylline, palbociclib, paroxetine
Constipation [5] Periorbital dermatitis [4] hydrochloride, pemetrexed, perampanel,
Endocrine/Metabolic Other phenylbutazone, pimavanserin, piracetam,
Adverse effects [2] ponatinib, posaconazole, prednisolone,
Acidosis [3]
prednisone, propranolol, regorafenib, rifapentine,
Renal rilpivirine, riociguat, risperidone, ritonavir,
Nephrotoxicity [2] rivaroxaban, roflumilast, romidepsin, saquinavir,
Other PHENYL- simeprevir, sofosbuvir, sofosbuvir & velpatasvir,
Death [4] sofosbuvir/velpatasvir/voxilaprevir, solifenacin,
Teratogenicity [2]
PROPANOLAMINE sonidegib, sorafenib, St John’s wort, sucralfate,
sunitinib, tegafur/gimeracil/oteracil, telaprevir,
telithromycin, temsirolimus, teniposide, tenofovir
alafenamide, thalidomide, tiagabine, ticagrelor,
PHENTOLAMINE ticlopidine, tinidazole, tipranavir, tizanidine,
tolvaptan, triamcinolone, trimethoprim, ulipristal,
Trade name: Regitine (Novartis)
uracil/tegafur, valbenazine, vandetanib,
Indications: Hypertensive episodes in
vemurafenib, venetoclax, vigabatrin, vorapaxar,
pheochromocytoma
voriconazole, vortioxetine, zidovudine,
Class: Adrenergic alpha-receptor antagonist
zuclopenthixol
Note: Aromatic antiepileptic drugs, phenytoin,
phenobarbital, carbamazepine and primidone, are
a frequent cause of severe cutaneous adverse
reactions. A strong genetic association between
PHENYTOIN Over 100 updates per week on www.drugeruptiondata.com
HLA-B*1502 and phenytoin-induced Stevens- Myasthenia gravis [2] Ocular burning (<10%)
Johnson syndrome and toxic epidermal necrolysis Osteoporosis [2] Ocular stinging (>10%)
has been shown in Han Chinese patients. Rhabdomyolysis [6]
Children whose mothers receive phenytoin Gastrointestinal/Hepatic
during pregnancy are born with fetal hydantoin
syndrome. The main features of this syndrome
Hepatotoxicity [10] PHYTONADIONE
are mental and growth retardation, unusual facies, Respiratory
Cough [2] Synonym: vitamin K1
digital and nail hypoplasia, and coarse scalp hair. Trade names: Mephyton (Valeant), Vitamin K
Occasionally neonatal acne will be present. Ocular (AbbVie)
Hallucinations, visual [2] Indications: Coagulation disorders
Skin Local Class: Vitamin
Acne keloid [2] Injection-site extravasation [2] Half-life: 24 hours
Acneform eruption [8] Injection-site necrosis [2] Clinically important, potentially hazardous
AGEP [5] Other interactions with: cholestyramine, orlistat,
Angioedema [2] Adverse effects [3] warfarin
Anticonvulsant hypersensitivity syndrome Death [4] Pregnancy category: C
[10] Hiccups [2] Important contra-indications noted in the
Coarse facies [4] Teratogenicity [3] prescribing guidelines for: nursing mothers;
Dermatomyositis [2] pediatric patients
DRESS syndrome [32]
Erythema multiforme [11] Skin
Erythroderma [9] PHYSOSTIGMINE Anaphylactoid reactions/Anaphylaxis [4]
Exanthems (671%) [22] Dermatitis [9]
Exfoliative dermatitis [15] Synonym: eserine
Indications: Miotic in glaucoma treatment, Eczema [2]
Fixed eruption [5] Nicolau syndrome [2]
Hypersensitivity [47] reverses toxic CNS effects caused by
anticholinergic drugs Scleroderma [12]
Kaposi’s varicelliform eruption [2] Urticaria [4]
Linear IgA bullous dermatosis [8] Class: Cholinesterase inhibitor
Lupus erythematosus [19] Half-life: 1540 minutes Local
Lymphoma [6] Clinically important, potentially hazardous Injection-site eczematous eruption [10]
Mycosis fungoides [7] interactions with: bethanechol, corticosteroids, Injection-site erythema [2]
Pemphigus [2] galantamine, methacholine, succinylcholine Injection-site induration [15]
Pigmentation [4] Pregnancy category: C Other
Pruritus [5] Important contra-indications noted in the Allergic reactions [2]
Pseudolymphoma [31] prescribing guidelines for: nursing mothers
Purple glove syndrome [10] Note: Antilirium is a derivative of the Calabar
Purpura [4] bean, and its active moiety, physostigmine, is also
Pustules [3] known as eserine. Physostigmine is used to PILOCARPINE
Rash (<10%) [13] reverse the effect upon the nervous system
caused by clinical or toxic dosages of drugs and Trade names: Ocusert Pilo (Akorn), Pilopine
Reticular hyperplasia [2] (Alcon), Salagen (MGI)
Serum sickness-like reaction [2] herbs capable of producing the anticholinergic
syndrome. Some of the drugs responsible are: Indications: Glaucoma, miosis induction,
Stevens-Johnson syndrome (14%) [58] xerostomia
Toxic epidermal necrolysis (2%) [65] amitriptyline, amoxapine, atropine, benztropine,
biperiden, clidinium, cyclobenzaprine, Class: Miotic, Muscarinic cholinergic agonist
Urticaria [5] Half-life: N/A
Vasculitis (2%) [11] desipramine, doxepin, hyoscyamine, imipramine,
lorazepam, maprotiline, nortriptyline, Clinically important, potentially hazardous
Hair protriptyline, propantheline, scopolamine, interactions with: acebutolol, galantamine
Alopecia [3] trimipramine. Some herbals that can elicit the Pregnancy category: C
Hirsutism [8] anticholinergic syndrome are black henbane, Important contra-indications noted in the
Nails deadly nightshade, Devil’s apple, Jimson weed, prescribing guidelines for: nursing mothers;
Nail changes [2] Loco seeds or weeds, Matrimony vine, night pediatric patients
Nail hypoplasia [3] blooming jessamine, stinkweed.
Mucosal Skin
Gingival hyperplasia/hypertrophy (>10%) Skin Burning (<10%)
[57] Diaphoresis (>10%) Dermatitis [4]
Mucocutaneous eruption [2] Erythema (<10%) Diaphoresis [5]
Edema (4%)
Cardiovascular Mucosal Hyperhidrosis [2]
Bradycardia [2] Sialorrhea (>10%) Hypersensitivity (<10%)
Polyarteritis nodosa [2] Cardiovascular Stinging (<10%)
Central Nervous System Atrial fibrillation [2] Central Nervous System
Ageusia (taste loss) [2] Bradycardia [3] Dysgeusia (taste perversion) (2%)
Fetal hydantoin syndrome [8] Central Nervous System Headache [2]
Hallucinations [2] Seizures (<10%) [4]
Neurotoxicity [2] Ocular
Twitching (<10%) Cataract [2]
Paresthesias [2]
Restless legs syndrome [2] Gastrointestinal/Hepatic
Nausea [4]
Neuromuscular/Skeletal Vomiting [3]
Digital malformations [4]
Myalgia/Myopathy [2] Ocular
Epiphora (>10%)
Litt’s Drug Eruption & Reaction Manual PIPECURONIUM
Rosacea [5]
PIMAVANSERIN Tinea [3] PIOGLITAZONE
Trade name: Nuplazid (Acadia) Cardiovascular Trade name: Actos (Takeda)
Indications: Hallucinations and delusions Cardiac arrest [2] Indications: Type II diabetes
associated with Parkinson’s disease psychosis Respiratory Class: Antidiabetic, CYP3A4 inducer,
Class: Antipsychotic Upper respiratory tract infection (19%) Thiazolidinedione
Half-life: 57 hours Local Half-life: 37 hours
Clinically important, potentially hazardous Application-site burning (826%) Clinically important, potentially hazardous
interactions with: amiodarone, carbamazepine, Application-site reactions (2%) interactions with: alcohol, conivaptan,
chlorpromazine, clarithromycin, disopyramide, corticosteroids, CYP2C8 inhibitors and inducers,
drugs known to prolong the QT interval, Other dapagliflozin, deferasirox, gemfibrozil, insulin,
gatifloxacin, indinavir, itraconazole, ketoconazole, Infection (5%) [2] pegvisomant, pregabalin, rifampin, saxagliptin,
moxifloxacin, phenytoin, procainamide, quinidine, somatropin, teriflunomide, trimethoprim
rifampin, sotalol, St John’s wort, strong CYP3A4 Pregnancy category: C
inhibitors and inducers, thioridazine, ziprasidone PIMOZIDE Important contra-indications noted in the
Pregnancy category: N/A (No data available) prescribing guidelines for: nursing mothers;
Important contra-indications noted in the Trade name: Orap (Teva) pediatric patients
prescribing guidelines for: the elderly; nursing Indications: Tourette’s syndrome, schizophrenia Note: Contra-indicated in patients with
mothers; pediatric patients Class: Antipsychotic established NYHA Class III or IV heart failure.
Warning: INCREASED MORTALITY IN Half-life: 50 hours Warning: CONGESTIVE HEART FAILURE
ELDERLY PATIENTS WITH DEMENTIA- Clinically important, potentially hazardous
RELATED PSYCHOSIS interactions with: amitriptyline, amoxapine, Skin
amphetamines, amprenavir, aprepitant, arsenic, Edema (411%) [29]
Skin artemether/lumefantrine, astemizole, atazanavir, Peripheral edema [12]
Peripheral edema (7%) [2] azithromycin, azole antifungals, boceprevir,
ceritinib, citalopram, clarithromycin, crizotinib, Cardiovascular
Central Nervous System darunavir, dasabuvir/ombitasvir/paritaprevir/ Cardiac failure (<10%) [14]
Confusion (6%) ritonavir, dasatinib, degarelix, delavirdine, Cardiomyopathy [3]
Gait instability (2%) [3] dirithromycin, dolasetron, droperidol, efavirenz, Cardiotoxicity [2]
Hallucinations (5%) [2] eluxadoline, enzalutamide, erythromycin, Myocardial infarction [3]
Gastrointestinal/Hepatic fluoxetine, fosamprenavir, grapefruit juice, Central Nervous System
Constipation (4%) imatinib, indinavir, itraconazole, ketoconazole, Headache (9%) [4]
Nausea (7%) lapatinib, levofloxacin, levomepromazine, Stroke [2]
Genitourinary lopinavir, lurasidone, methylphenidate, Neuromuscular/Skeletal
Urinary tract infection [2] mifepristone, moxifloxacin, nefazodone, Asthenia (fatigue) (4%)
nelfinavir, nilotinib, ombitasvir/paritaprevir/ Bone loss [4]
ritonavir, paroxetine hydrochloride, pazopanib, Fractures [10]
pemoline, phenothiazines, posaconazole,
PIMECROLIMUS protease inhibitors, quinidine, quinine, ribociclib,
ritonavir, saquinavir, sertraline, sotalol, Gastrointestinal/Hepatic
Trade name: Elidel (Valeant) sparfloxacin, sulpiride, telaprevir, telavancin, Diarrhea [4]
Indications: Second-line therapy for the short- telithromycin, thioridazine, tipranavir, tricyclic Hepatotoxicity [8]
term and non-continuous chronic treatment of antidepressants, trifluoperazine, troleandomycin, Nausea [3]
mild to moderate atopic dermatitis vandetanib, voriconazole, vorinostat, zileuton, Vomiting [2]
Class: Immunomodulator, Macrolactam ziprasidone Respiratory
Half-life: N/A Pregnancy category: C Nasopharyngitis [3]
Clinically important, potentially hazardous Important contra-indications noted in the Pharyngitis (5%)
interactions with: abatacept, alcohol, alefacept, prescribing guidelines for: nursing mothers; Sinusitis (6%)
aprepitant, azacitidine, betamethasone, pediatric patients Upper respiratory tract infection (13%)
cabazitaxel, calcium channel blockers, cimetidine,
conivaptan, CYP3A4 inhibitors, darunavir, Endocrine/Metabolic
delavirdine, denileukin, docetaxel, efavirenz, Skin Hypoglycemia [10]
erythromycin, fingolimod, fluconazole, gefitinib, Facial edema (<10%) Weight gain [19]
immunosuppressants, indinavir, itraconazole, Rash (8%) Genitourinary
ketoconazole, lapatinib, leflunomide, Mucosal Bladder cancer [7]
lenalidomide, oxaliplatin, pazopanib, pemetrexed, Sialorrhea (14%) Hematologic
telithromycin, temsirolimus, triamcinolone, Xerostomia (>10%) [3]
Anemia (<2%) [2]
voriconazole Cardiovascular Pancytopenia [2]
Pregnancy category: C QT prolongation [4]
prescribing guidelines for: nursing mothers; Neuromuscular/Skeletal Macular edema [2]
pediatric patients Myalgia/Myopathy (3%) Other
Warning: LONG-TERM SAFETY OF TOPICAL Endocrine/Metabolic Adverse effects [4]
CALCINEURIN INHIBITORS HAS NOT BEEN Gynecomastia (>10%) Death [3]
ESTABLISHED. Tooth disorder (5%)
Skin PINDOLOL
Burning [4] PIPECURONIUM
Dermatitis [2] See: www.drugeruptiondata.com/drug/id/563
Peripheral edema [3] See: www.drugeruptiondata.com/drug/id/949
PIPERACILLIN See all our books at www.crcpress.com
Skin Angioedema [3]

PIPERACILLIN Photosensitivity (9%) [21] Dermatitis [5]
Phototoxicity [2] Erythema multiforme [12]
See: www.drugeruptiondata.com/drug/id/565 Pruritus (8%) [3] Erythroderma [2]
Rash (30%) [13] Exanthems (>5%) [8]
Cardiovascular Fixed eruption [15]
PIPERACILLIN/ Chest pain (5%) [3] Lichenoid eruption [5]
TAZOBACTAM Central Nervous System Pemphigus [3]
Anorexia (13%) [10] Photosensitivity [40]
Trade name: Zosyn (Wyeth) Dysgeusia (taste perversion) (6%) Pruritus (<10%) [6]
Indications: Moderate to severe infections Headache (22%) [3] Purpura [2]
Class: Antibacterial Insomnia (10%) Rash (>10%)
Half-life: 0.7-1.2 hours Sedation [2] Stevens-Johnson syndrome [2]
Clinically important, potentially hazardous Vertigo (dizziness) (18%) [6] Toxic epidermal necrolysis [12]
interactions with: heparin, methotrexate Neuromuscular/Skeletal Urticaria [7]
Pregnancy category: B Arthralgia (10%) Vasculitis [3]
Important contra-indications noted in the Asthenia (fatigue) (6–26%) [8] Vesiculation [2]
Gastrointestinal/Hepatic Hair
Abdominal pain (24%) [7] Alopecia [3]
Skin Diarrhea (26%) [10] Mucosal
AGEP [2] Dyspepsia (19%) [9] Aphthous stomatitis [4]
DRESS syndrome [3] Gastroesophageal reflux (11%) [5]
Hypersensitivity [2] Gastrointestinal disorder [2] Central Nervous System
Rash [5] Hepatotoxicity [4] Anorexia (<10%)
Nausea (36%) [17] Vertigo (dizziness) (<10%)
Fever [3] Vomiting (13%) [6] Gastrointestinal/Hepatic
Neurotoxicity [2] Respiratory Abdominal pain (<10%)
Cough [2] Constipation (<10%)
Dyspnea [2] Diarrhea (<10%)
Diarrhea [4]
Nasopharyngitis [2] Dyspepsia (<10%)
Hepatotoxicity [3]
Sinusitis (11%) Flatulence (<10%)
Nausea [2]
Upper respiratory tract infection (27%) [2] Gastrointestinal ulceration (<10%)
Vomiting [2]
Nausea (<10%)
Endocrine/Metabolic Endocrine/Metabolic Vomiting (<10%)
Hypokalemia [3] ALT increased [5]
Appetite decreased (8%) [3] Renal
Renal Renal function abnormal (<10%)
Nephrotoxicity [4] AST increased [5]
Weight loss (10%) [3] Otic
Hematologic Hearing loss [2]
Hemolytic anemia [3]
Other
Adverse effects [9] Tinnitus [2]
Hemotoxicity [2]
Other
Adverse effects [2]
Other Side effects (47%)
Adverse effects [3] PIROXICAM
Trade name: Feldene (Pfizer)
Indications: Arthritis PITAVASTATIN
PIRACETAM Class: Non-steroidal anti-inflammatory (NSAID)
Half-life: 50 hours Trade name: Livalo (Kowa)
See: www.drugeruptiondata.com/drug/id/1328 Clinically important, potentially hazardous Indications: Primary hyperlipidemia, mixed
interactions with: ACE inhibitors, aspirin, dyslipidemia
furosemide, lithium, methotrexate, ritonavir, Class: Statin
PIRBUTEROL warfarin Half-life: 12 hours
Pregnancy category: D (pregnancy category C Clinically important, potentially hazardous
See: www.drugeruptiondata.com/drug/id/566 prior to 30 weeks gestation; category D starting interactions with: alcohol, cyclosporine,
at 30 weeks gestation) erythromycin, gemfibrozil, lopinavir, niacin,
Important contra-indications noted in the rifampin, ritonavir, sofosbuvir/velpatasvir/
prescribing guidelines for: the elderly; nursing voxilaprevir
PIRFENIDONE mothers Pregnancy category: X
Note: NSAIDs may cause an increased risk of Important contra-indications noted in the
Trade name: Esbriet (Intermune)
serious cardiovascular and gastrointestinal prescribing guidelines for: nursing mothers;
Indications: Idiopathic pulmonary fibrosis
adverse events, which can be fatal. This risk may pediatric patients
Class: Immunosuppressant, Pyridone
increase with duration of use. Note: Contra-indicated in patients with active
Half-life: 3 hours
Elderly patients are at greater risk for serious liver disease.
gastrointestinal events.
interactions with: ciprofloxacin, fluvoxamine
Warning: CARDIOVASCULAR AND Skin
GASTROINTESTINAL RISKS Hypersensitivity (<2%)
prescribing guidelines for: nursing mothers; Rash (<2%)
pediatric patients Skin Urticaria (<2%)
AGEP [2]
Litt’s Drug Eruption & Reaction Manual POMALIDOMIDE
Central Nervous System Pregnancy category: C

Headache (<2%) PNEUMOCOCCAL Important contra-indications noted in the
Neuromuscular/Skeletal VACCINE pediatric patients
Arthralgia (<2%)
Back pain (2–4%) Note: Severe allergic reactions have been
Trade names: PCV (Lederle), PncOMP (Merck),
Myalgia/Myopathy (2–3%) [5] reported following polidocanol use, including
Pneumovax II (Sanofi-Aventis), Pnu-Immune
Pain in extremities (<2%) anaphylactic reactions, some of them fatal. Severe
(Lederle), PPV (Lederle), Prevnar (Wyeth)
reactions are more frequent with use of larger
Gastrointestinal/Hepatic Indications: Prevention of bacteremia,
volumes (>3 mL).
Constipation (2–4%) meningitis, pneumonia, respiratory tract
Contra-indicated in patients with acute
Diarrhea (2–3%) infections, otitis media, sinusitis
thromboembolic diseases.
Class: Vaccine
Respiratory Half-life: N/A
Influenza (<2%) Clinically important, potentially hazardous Skin
Nasopharyngitis (<2%) [2] interactions with: none known Anaphylactoid reactions/Anaphylaxis [4]
Endocrine/Metabolic Pregnancy category: C Pigmentation [2]
ALT increased [2] Urticaria [2]
AST increased [2] Skin Cardiovascular
Creatine phosphokinase increased [2] Anaphylactoid reactions/Anaphylaxis [2] Cardiac arrest [2]
Other Rash [2] Phlebitis [2]
Adverse effects [4] Serum sickness [2] Central Nervous System
Sweet’s syndrome [2] Migraine [2]
Urticaria [5]
PIZOTIFEN Central Nervous System Leg pain [2]
Fever [21]
See: www.drugeruptiondata.com/drug/id/1369 Hematologic
Headache [4]
Thrombosis [2]
Irritability [3]
Seizures [4] Local
PLASMA (HUMAN) Sleep disturbances [2] Injection-site hematoma (42%)
Injection-site irritation (41%)
BLOOD PRODUCT Arthralgia [3]
Injection-site pain (24%)
Injection-site pigmentation (38%)
See: www.drugeruptiondata.com/drug/id/3195 Injection-site pruritus (19%)
Respiratory Injection-site thrombosis (6%)
Respiratory tract infection [2]
PLECANATIDE * Endocrine/Metabolic
Trade name: Trulance (Synergy) Appetite decreased [3] POLYTHIAZIDE
Indications: Chronic idiopathic constipation Local
Class: Guanylate cyclase-C agonist Injection-site edema [8] See: www.drugeruptiondata.com/drug/id/569
Half-life: N/A Injection-site erythema [10]
Clinically important, potentially hazardous Injection-site induration [3]
interactions with: none known Injection-site pain [10] POMALIDOMIDE
Pregnancy category: N/A (Insufficient data to Injection-site reactions [10]
inform drug-associated risks) Other Trade name: Pomalyst (Celgene)
Important contra-indications noted in the Adverse effects [3] Indications: Multiple myeloma in patients who
prescribing guidelines for: the elderly; nursing have received at least two prior therapies
mothers; pediatric patients including lenalidomide and bortezomib
Warning: RISK OF SERIOUS DEHYDRATION Class: Immunomodulator, Thalidomide analog
IN PEDIATRIC PATIENTS PODOPHYLLOTOXIN Half-life: 7.5–9.5 hours
Gastrointestinal/Hepatic interactions with: ketoconazole, P-glycoprotein,
Abdominal distension (<2%) rifampin
Abdominal pain [2] Pregnancy category: X
Diarrhea (5%) [5] POLIDOCANOL Important contra-indications noted in the
Flatulence (<2%) prescribing guidelines for: nursing mothers;
Nausea [2] Trade names: Asclera (Chemische Fabrik pediatric patients
Vomiting [2] Kreussler), Varithena (BTG) Warning: EMBRYO-FETAL TOXICITY and
Indications: Uncomplicated spider veins and VENOUS AND ARTERIAL
Respiratory uncomplicated reticular veins in the lower THROMBOEMBOLISM
Sinusitis (<2%) extremity
Upper respiratory tract infection (<2%) Class: Sclerosant, local
Skin
Endocrine/Metabolic Half-life: 1.5 hours
Edema [4]
ALT increased (<2%) Clinically important, potentially hazardous
Hyperhidrosis (6%)
AST increased (<2%) interactions with: none known
Pruritus (15%)
Rash (22%) [2]
PLICAMYCIN Xerosis (9%)
POMALIDOMIDE Over 100 updates per week on www.drugeruptiondata.com
Mucosal Neuromuscular/Skeletal
Epistaxis (nosebleed) (15%) PORFIMER Arthralgia (11%)
Cardiovascular Asthenia (fatigue) (3–17%) [2]
See: www.drugeruptiondata.com/drug/id/1177 Back pain (10%)
Chest pain (22%)
Venous thromboembolism [8] Bone or joint pain (16%)
Central Nervous System POSACONAZOLE
Anxiety (11%) Gastrointestinal/Hepatic
Chills (9%) Abdominal pain (5–27%) [3]
Trade name: Noxafil (Schering) Constipation (21%)
Confusion (10%) Indications: Aspergillus and Candida infection
Fever (19%) [3] Diarrhea (10–42%) [6]
prophylaxis in immunocompromised patients Dyspepsia (10%)
Headache (13%) Class: Antibiotic, triazole, Antifungal, azole
Insomnia (7%) Flatulence [2]
Half-life: 35 hours Hepatitis (<5%)
Neurotoxicity (18%) [3] Clinically important, potentially hazardous
Pain (6%) Hepatomegaly (<5%)
interactions with: alprazolam, atazanavir, Hepatotoxicity (<5%) [6]
Peripheral neuropathy (10%) [2] atorvastatin, boceprevir, brigatinib, cabozantinib,
Tremor (9%) [2] Nausea (9–38%) [11]
calcium channel blockers, cimetidine, copanlisib, Vomiting (7–29%) [5]
Vertigo (dizziness) (20%) cyclosporine, digoxin, dihydroergotamine,
Neuromuscular/Skeletal diltiazem, dronedarone, efavirenz, ergotamine, Respiratory
Arthralgia (16%) esomeprazole, everolimus, felodipine, flibanserin, Cough (3–25%)
Asthenia (fatigue) (12–55%) [10] fosamprenavir, HMG-CoA reductase inhibitors, Dyspnea (<20%)
Back pain (32%) [3] ibrutinib, lapatinib, lomitapide, lovastatin, Pharyngitis (12%)
Bone or joint pain (11–12%) [2] metoclopramide, midazolam, midostaurin, Pneumonia (3–10%)
Muscle spasm (19%) mifepristone, neratinib, nicardipine, nifedipine, Pulmonary embolism (<5%)
Myalgia/Myopathy [2] olaparib, omeprazole, palbociclib, pantoprazole, Upper respiratory tract infection (7%)
Pain in extremities (5%) phenytoin, pimozide, ponatinib, quinidine, Endocrine/Metabolic
Gastrointestinal/Hepatic regorafenib, rifabutin, rilpivirine, ritonavir, Adrenal insufficiency (<5%)
Constipation (36%) [2] rivaroxaban, ruxolitinib, simeprevir, simvastatin, ALP increased (3–13%)
Diarrhea (34%) [2] sirolimus, sonidegib, tacrolimus, telaprevir, ALT increased (3–11%) [2]
Nausea (36%) temsirolimus, triazolam, venetoclax, verapamil, AST increased (6–17%) [2]
Vomiting (14%) vinblastine, vincristine, vorapaxar Dehydration (<11%)
Pregnancy category: C Hyperbilirubinemia [2]
Respiratory Important contra-indications noted in the Hyperglycemia (11%)
Cough (14%) prescribing guidelines for: nursing mothers; Hypocalcemia (9%)
Dyspnea (34%) [5] pediatric patients Hypokalemia (30%)
Pneumonia (23%) [7] Hypomagnesemia (18%)
Upper respiratory tract infection (32%) Weight loss (<14%)
Skin
Endocrine/Metabolic Edema (9%) Genitourinary
Appetite decreased (22%) Herpes (14%) Vaginal bleeding (10%)
Dehydration [2] Herpes simplex (3–15%)
Hypercalcemia (21%) Renal
Hyperhidrosis (2–10%) Renal failure (<5%)
Hyperglycemia (12%) [2] Jaundice (<5%)
Hypocalcemia (6%) Peripheral edema (15%) Hematologic
Hypokalemia (10%) Petechiae (11%) Anemia (2–25%)
Hyponatremia (10%) Pruritus (11%) Febrile neutropenia (20%)
Serum creatinine increased (15%) Rash (3–19%) [3] Hemolytic uremic syndrome (<5%)
Weight loss (14%) Thrombocytopenic purpura (<5%) Neutropenia (4–23%)
Genitourinary Thrombocytopenia (29%)
Mucosal
Urinary tract infection (8%) Epistaxis (nosebleed) (14%) Ocular
Renal Mucositis (17%) Vision blurred (~2%)
Renal failure (15%) Oral candidiasis (<12%) Other
Hematologic Cardiovascular Adverse effects [11]
Anemia (38%) [13] Hypertension (18%) Allergic reactions (<5%)
Febrile neutropenia [2] Hypotension (14%) Infection (18%)
Leukopenia (11%) [3] QT prolongation [3]
Lymphopenia (4%) [2] Tachycardia (12%)
Myelosuppression [4] Torsades de pointes (<5%) POTASSIUM IODIDE
Neutropenia (52%) [22] Central Nervous System
Sepsis [2] Anorexia (2–19%) Synonyms: KI; Lugol’s solution
Thrombocytopenia (25%) [14] Anxiety (9%) Trade name: SSKI (Upsher-Smith)
Other Dysgeusia (taste perversion) (~2%) Indications: Hyperthyroidism, erythema
Death [3] Fever (6–45%) nodosum, sporotrichosis
Infection [9] Headache (8–28%) [6] Class: Antihyperthyroid, Antimycobacterial
Insomnia (<17%) Half-life: N/A
Neurotoxicity [2] Clinically important, potentially hazardous
Paresthesias (<5%) interactions with: ACE inhibitors, potassium-
PONATINIB Rigors (<20%) sparing diuretics, spironolactone, triamterene
Tremor (~2%)
Litt’s Drug Eruption & Reaction Manual PRASUGREL
Pregnancy category: D Skin

Important contra-indications noted in the Edema (5%) PRASTERONE *
prescribing guidelines for: nursing mothers Peripheral edema (5%) [3]
Trade name: Intrarosa (Endoceutics)
Mucosal Indications: Moderate to severe dyspareunia, a
Skin Xerostomia (7%) [3] symptom of vulvar and vaginal atrophy, due to
Acneform eruption (<10%) [3] Cardiovascular menopause
Angioedema (<10%) Chest pain (3%) Class: Steroid
Bullous pemphigoid [2] Hypotension (~53%) [2] Half-life: N/A
Dermatitis herpetiformis [2] Orthostatic hypotension [2] Clinically important, potentially hazardous
Iododerma [17] interactions with: none known
Psoriasis [2] Central Nervous System
Abnormal dreams (11%) Pregnancy category: N/A (Indicated for post-
Urticaria (<10%) menopausal women only)
Vasculitis [3] Akathisia (2–3%)
Amnesia (4–6%) Note: Contra-indicated in patients with
Central Nervous System Anorexia (<5%) undiagnosed abnormal genital bleeding or with a
Dysgeusia (taste perversion) (<10%) [2] Compulsions [6] known or suspected history of breast cancer.
Gastrointestinal/Hepatic Confusion [2]
Gastrointestinal disorder [2] Depression (2%) Genitourinary
Endocrine/Metabolic Dyskinesia (17–47%) [3] Vaginal discharge (5–14%) [2]
Hypothyroidism [2] Hallucinations (5–17%) [6]
Hyperesthesia (3%)
Impulse control disorder [10]
PRASUGREL
PRALATREXATE Insomnia (4–27%) [2] Trade name: Effient (Lilly)
Restless legs syndrome [2] Indications: Acute coronary syndrome in
See: www.drugeruptiondata.com/drug/id/1431 Somnolence (drowsiness) (9–36%) [9] patients who are to be managed with
Tremor (4%) percutaneous coronary intervention
Twitching (2%) Class: Antiplatelet, thienopyridine
PRALIDOXIME Vertigo (dizziness) (2–26%) [6] Half-life: 2–15 hours
Neuromuscular/Skeletal Clinically important, potentially hazardous
Trade name: Protopam (Baxter) Antecollis [2] interactions with: cangrelor, clopidogrel,
Indications: Muscle weakness and respiratory Arthralgia (4%) conivaptan, coumarins, darunavir, delavirdine,
depression caused by organophosphate drugs Asthenia (fatigue) (<14%) [2] diclofenac, indinavir, meloxicam, NSAIDs,
which have anticholinesterase activity, antidote to phenindione, telithromycin, voriconazole,
overdose of anticholinesterase drugs Gastrointestinal/Hepatic
Constipation [5] warfarin
Class: Antidote Pregnancy category: B
Half-life: 2.4–5.3 hours Nausea [9]
Vomiting (4%) [3] Important contra-indications noted in the
Clinically important, potentially hazardous prescribing guidelines for: the elderly; nursing
interactions with: succinylcholine Respiratory mothers; pediatric patients
Pregnancy category: C Cough (3%) Note: Contra-indicated in patients with active
Important contra-indications noted in the Dyspnea (4%) pathological bleeding, prior transient ischemic
prescribing guidelines for: the elderly; nursing Rhinitis (3%) attack or stroke.
mothers Warning: BLEEDING RISK
Genitourinary
Note: Pralidoxime is not effective in the
Urinary frequency (6%)
treatment of poisoning due to phosphorus,
Urinary tract infection (4%) Skin
inorganic phosphates, or organophosphates not
having anticholinesterase activity. Pralidoxime is Other Hypersensitivity [2]
not indicated as an antidote for intoxication by Adverse effects (2%) [5] Peripheral edema (3%)
pesticides of the carbamate class since it may Rash (3%) [4]
increase the toxicity of carbaryl. In therapy it has Mucosal
been difficult to differentiate side effects due to PRAMLINTIDE Epistaxis (nosebleed) (6%)
the drug from those due to the effects of the Cardiovascular
poison. See: www.drugeruptiondata.com/drug/id/1069 Atrial fibrillation (3%)
Bradycardia (3%)
Chest pain (3%)
PRAMIPEXOLE PRANLUKAST Hypertension (8%)
Hypotension (4%)
Trade name: Mirapex (Boehringer Ingelheim) See: www.drugeruptiondata.com/drug/id/1269 Central Nervous System
Indications: Parkinsonism, restless legs Fever (3%)
syndrome Headache (6%)
Class: Dopamine receptor agonist
Half-life: ~8 hours
PRANOPROFEN Vertigo (dizziness) (4%)
See: www.drugeruptiondata.com/drug/id/1278 Asthenia (fatigue) (4%)
interactions with: levomepromazine,
risperidone, zuclopenthixol Back pain (5%)
Pregnancy category: C Pain in extremities (3%)
prescribing guidelines for: nursing mothers; Diarrhea (3%)
pediatric patients Gastrointestinal bleeding (2%)
Nausea (5%)
PRASUGREL See all our books at www.crcpress.com
Respiratory Cough (3–8%)

Cough (4%) Influenza (9%) PRAZOSIN
Dyspnea (5%) Pharyngitis (2%)
Respiratory distress [2] Pulmonary toxicity (4%) See: www.drugeruptiondata.com/drug/id/575
Endocrine/Metabolic Rhinitis (4%)
Hypercholesterolemia (7%) Upper respiratory tract infection (6–21%)
Hyperlipidemia (7%) Endocrine/Metabolic PREDNICARBATE
Hematologic ALT increased (3%)
Creatine phosphokinase increased (4%) [3] See: www.drugeruptiondata.com/drug/id/1095
Anemia (2%)
Bleeding (<14%) [24] GGT increased (2%)
Hemorrhage [2] Weight gain (4%)
Leukopenia (3%) Weight loss (3%) PREDNISOLONE
Other Genitourinary
Urinary tract infection (3%) Trade names: Blephamide (Allergan), Delta-
Adverse effects [2] Cortef (Pharmacia), Hydeltrasol (Merck),
Malignant neoplasms (2%) Renal Inflamase (Novartis), Pediapred (UCB), Prelone
Renal failure [2] (Teva)
Ocular Indications: Arthralgias, asthma, dermatoses,
PRAVASTATIN Diplopia (3%) inflammatory ocular conditions
Vision blurred (3%) Class: Corticosteroid, systemic
Trade names: Lipostat (Bristol-Myers Squibb), Other Half-life: 2–4 hours
Pravachol (Bristol-Myers Squibb) Adverse effects [2] Clinically important, potentially hazardous
Indications: Hypercholesterolemia Infection (3%) interactions with: aluminum, aminophylline,
Class: HMG-CoA reductase inhibitor, Statin carbamazepine, carbimazole, cyclosporine,
Half-life: ~23 hours daclizumab, diuretics, etoposide, etretinate,
Clinically important, potentially hazardous grapefruit juice, indomethacin, isoniazid,
interactions with: azithromycin, ciprofibrate, PRAZEPAM itraconazole, ketoconazole, live vaccines,
clarithromycin, colchicine, cyclosporine, methotrexate, naproxen, oral contraceptives,
darunavir, efavirenz, erythromycin, gemfibrozil, See: www.drugeruptiondata.com/drug/id/573 pancuronium, phenobarbital, phenytoin, rifampin,
imatinib, red rice yeast, telithromycin troleandomycin
Pregnancy category: X Pregnancy category: C
Important contra-indications noted in the PRAZIQUANTEL
prescribing guidelines for: nursing mothers Skin
Trade name: Biltricide (Bayer) Acneform eruption [4]
Skin Indications: Helmintic infections AGEP [2]
Dermatomyositis [2] Class: Anthelmintic Candidiasis [2]
Eczema (generalized) [2] Half-life: 0.81.5 hours Dermatitis [3]
Edema (3%) Clinically important, potentially hazardous Edema [7]
Lichenoid eruption [2] interactions with: dexamethasone, efavirenz, Erythema [2]
Pruritus [2] oxcarbazepine, rifampin, rifapentine Erythema multiforme [2]
Rash (5–7%) [7] Pregnancy category: B Exanthems [3]
Important contra-indications noted in the Kaposi’s sarcoma [3]
Cardiovascular prescribing guidelines for: nursing mothers
Angina (5%) Pruritus [2]
Chest pain (3–10%) Stevens-Johnson syndrome [2]
Skin Toxicity [2]
Central Nervous System Diaphoresis (<10%)
Anxiety (5%) Hair
Edema [2] Alopecia [2]
Fever (2%) Pruritus [3]
Headache (6%) Rash [2] Cardiovascular
Nervousness (5%) Urticaria [5] Atrial fibrillation [2]
Paresthesias (3%) Cardiotoxicity [4]
Sleep disturbances (3%) Central Nervous System Flushing [2]
Vertigo (dizziness) (4–7%) Fever [2] Hypertension [13]
Headache [7] Tachycardia [2]
Neuromuscular/Skeletal Seizures [2]
Asthenia (fatigue) (3–8%) Somnolence (drowsiness) [2] Central Nervous System
Bone or joint pain (25%) Vertigo (dizziness) [7] Behavioral disturbances [2]
Cramps (5%) Depression [4]
Myalgia/Myopathy (2–3%) [9] Neuromuscular/Skeletal
Asthenia (fatigue) [3] Neuromuscular/Skeletal
Rhabdomyolysis [24] Arthralgia [4]
Gastrointestinal/Hepatic Gastrointestinal/Hepatic Asthenia (fatigue) [5]
Abdominal distension (2%) Abdominal pain [9] Back pain [4]
Diarrhea (7%) Diarrhea [5] Bone or joint pain [5]
Dyspepsia (3%) Nausea [5] Myalgia/Myopathy [2]
Flatulence (3%) Vomiting [6] Osteonecrosis [4]
Nausea (7%) Other Osteoporosis [32]
Pancreatitis [4] Adverse effects [2] Gastrointestinal/Hepatic
Vomiting (7%) Allergic reactions [2] Constipation [3]
Respiratory Diarrhea [2]
Bronchitis (3%) Hepatotoxicity [6]
Litt’s Drug Eruption & Reaction Manual PRILOCAINE
Nausea [2] Central Nervous System Impaired concentration [2]

Pancreatitis [2] Headache [3] Insomnia [3]
Respiratory Leukoencephalopathy [3] Memory loss [2]
Upper respiratory tract infection [2] Peripheral neuropathy [4] Neurotoxicity [3]
Neuromuscular/Skeletal Pain (5%)
Endocrine/Metabolic Sedation [6]
Cushing’s syndrome [2] Arthralgia [2]
Asthenia (fatigue) [7] Somnolence (drowsiness) [45]
Diabetes mellitus [4] Suicidal ideation [4]
Hyperglycemia [3] Bone or joint pain [2]
Fractures [3] Tremor [2]
Hypokalemia [7] Vertigo (dizziness) (4%) [58]
Hematologic Osteonecrosis [3] Neuromuscular/Skeletal
Anemia [3] Osteoporosis [23] Asthenia (fatigue) (5%) [8]
Febrile neutropenia [3] Ataxia [8]
Neutropenia [4] Gastrointestinal/Hepatic
Constipation [3] Back pain (2%)
Thrombocytopenia [2] Muscle spasm [2]
Diarrhea [4]
Ocular Nausea [4] Myoclonus [4]
Cataract [5] Vomiting [2] Rhabdomyolysis [3]
Chorioretinopathy [2] Gastrointestinal/Hepatic
Glaucoma [2] Respiratory
Cough [2] Constipation [5]
Intraocular pressure increased [4] Diarrhea [2]
Other Endocrine/Metabolic Nausea [9]
Adverse effects [11] Diabetes mellitus [2] Vomiting [3]
Allergic reactions [2] Hyperglycemia [3]
Weight gain [2] Endocrine/Metabolic
Death [2] Appetite increased [2]
Infection [17] Hematologic Weight gain [21]
Side effects [4] Anemia [5]
Febrile neutropenia [3] Genitourinary
Leukopenia [3] Erectile dysfunction [3]
PREDNISONE Lymphopenia [3] Ocular
Neutropenia [15] Diplopia (9%) [2]
Trade names: Deltasone (Pharmacia), Thrombocytopenia [10] Ocular edema [2]
Meticorten (Schering) Ocular Vision blurred (6%) [7]
Indications: Arthralgias, asthma, dermatoses, Cataract [3] Other
inflammatory ocular conditions Other Adverse effects [6]
Class: Corticosteroid, systemic
Adverse effects [10] Infection (7%)
Half-life: N/A
Death [3] Side effects [2]
Infection [12]
interactions with: aluminum, aminophylline,
Side effects [3]
aspirin, chlorambucil, cimetidine, clarithromycin,
cyclophosphamide, cyclosporine, dicumarol,
PRENYLAMINE
diuretics, docetaxel, estrogens, grapefruit juice, See: www.drugeruptiondata.com/drug/id/1985
indomethacin, influenza vaccine, itraconazole, PREGABALIN
ketoconazole, lansoprazole, live vaccines,
methotrexate, montelukast, omeprazole, oral Trade name: Lyrica (Pfizer)
contraceptives, pancuronium, phenobarbital, Indications: Neuropathy, post-herpetic PRILOCAINE
phenytoin, ranitidine, rifampin, timolol, neuralgia, partial epilepsy, fibromyalgia
tolbutamide, vitamin A, yellow fever vaccine Class: Anticonvulsant, GABA analog Trade name: Citanest (AstraZeneca)
Pregnancy category: B Half-life: 6 hours Indications: Local anesthetic
Important contra-indications noted in the Clinically important, potentially hazardous Class: Membrane integrity antagonist, Potassium
prescribing guidelines for: the elderly; nursing interactions with: lacosamide, pioglitazone channel antagonist, Sodium channel antagonist
mothers Pregnancy category: C Half-life: 2 hours
prescribing guidelines for: nursing mothers; interactions with: adenosine, amide-type
Skin pediatric patients anesthetics, antimalarials, co-trimoxazole,
Dermatitis [4] dronedarone, nitric compounds, sulfonamides
Ecchymoses [2] Pregnancy category: B
Erythema [3] Skin
Kaposi’s sarcoma [7] Edema (2%) [9]
Squamous cell carcinoma [2] Peripheral edema (9%) [14]
pediatric patients
Thinning [2] Mucosal
Toxicity [2] Xerostomia (5%) [11]
Skin
Hair Cardiovascular Angioedema [3]
Alopecia [2] Cardiac failure [3] Contact dermatitis [3]
Mucosal Chest pain (2%) Hypersensitivity [2]
Stomatitis [2] Central Nervous System Petechiae [3]
Cardiovascular Anorgasmia [2] Purpura [3]
Cardiotoxicity [2] Confusion [2] Central Nervous System
Hypertension [7] Depression [2] Coma [4]
Gait instability [4] Paresthesias [3]
Headache (7%) [8]
PRILOCAINE Over 100 updates per week on www.drugeruptiondata.com
Seizures [2]
Hematologic
PROCAINAMIDE PROCHLORPERAZINE
Methemoglobinemia [11] Trade names: Procan (Pfizer), Procanbid (Pfizer) Trade name: Compazine (GSK)
Other Indications: Ventricular arrhythmias Indications: Psychotic disorders, control of
Adverse effects [2] Class: Antiarrhythmic, Antiarrhythmic class Ia severe nausea and vomiting
Half-life: 2.54.5 hours Class: Antiemetic, Antipsychotic, Muscarinic
Clinically important, potentially hazardous antagonist, Phenothiazine
PRIMAQUINE interactions with: abarelix, amiodarone,
amisulpride, arsenic, artemether/lumefantrine,
Half-life: 23 hours
See: www.drugeruptiondata.com/drug/id/576 asenapine, astemizole, ciprofloxacin, enoxacin, interactions with: antihistamines, arsenic,
ethoxzolamide, gatifloxacin, glycopyrrolate, chlorpheniramine, dofetilide, pericyazine,
glycopyrronium, imidapril, lomefloxacin, piperazine, quinine, quinolones, sparfloxacin
lurasidone, metformin, mivacurium, moxifloxacin, Pregnancy category: C
PRIMIDONE nilotinib, norfloxacin, ofloxacin, pimavanserin, Important contra-indications noted in the
quinine, quinolones, ribociclib, rocuronium, prescribing guidelines for: the elderly; nursing
See: www.drugeruptiondata.com/drug/id/577 sotalol, sparfloxacin, tetrabenazine, trimethoprim, mothers; pediatric patients
trospium, vandetanib, zofenopril
PRISTINAMYCIN Important contra-indications noted in the Anaphylactoid reactions/Anaphylaxis
prescribing guidelines for: nursing mothers; (<10%)
See: www.drugeruptiondata.com/drug/id/1311 pediatric patients Fixed eruption [3]
Photosensitivity (<10%) [3]
Skin Pruritus (<10%)
PROBENECID Dermatitis (6%) Rash (<10%)
Exanthems (<8%) [5] Toxic epidermal necrolysis [2]
Indications: Gouty arthritis Hypersensitivity [2] Mucosal
Class: Uricosuric Lupus erythematosus (>10%) [175] Xerostomia (>10%)
Half-life: 612 hours (dose-dependent) Purpura [3]
Clinically important, potentially hazardous Urticaria (<5%) Central Nervous System
interactions with: acemetacin, acetaminophen, Vasculitis [5] Akathisia [14]
amphotericin B, ampicillin/sulbactam, Extrapyramidal symptoms [3]
Mucosal Neuroleptic malignant syndrome [3]
benzodiazepines, captopril, cefazolin, cefditoren, Oral mucosal eruption (2%)
cefixime, ceftaroline fosamil, ceftazidime & Parkinsonism [4]
avibactam, ceftriaxone, ciprofloxacin, Cardiovascular Neuromuscular/Skeletal
deferiprone, doripenem, ertapenem, Hypotension [2] Dystonia [6]
flucloxacillin, furosemide, gemifloxacin, QT prolongation [4]
Torsades de pointes [3] Endocrine/Metabolic
glibenclamide, ketoprofen, ketorolac, levodopa,
Gynecomastia (<10%)
levofloxacin, meloxicam, meropenem & Central Nervous System
vaborbactam, methotrexate, moxifloxacin, Dysgeusia (taste perversion) (34%)
norfloxacin, NSAIDs, ofloxacin, pemetrexed, Psychosis [2]
penicillamine, penicillin G, penicillin V, salicylates,
PROCYCLIDINE
sulfamethoxazole, sulfonamides, torsemide,
zidovudine
prescribing guidelines for: nursing mothers; Hepatotoxicity [3]
Nausea [3]
PROGESTINS
pediatric patients
Respiratory Trade names: Aygestin (Barr), Megace (Bristol-
Skin Pulmonary toxicity [2] Myers Squibb), Micronor (Ortho), Ovrette
Pruritus (<10%) Hematologic (Wyeth), Provera (Pfizer)
Rash (<10%) Agranulocytosis [4] Indications: Prevention of pregnancy
Urticaria (<5%) Neutropenia [3] Class: Progestogen
Pancytopenia [2] Half-life: N/A
Gingivitis (<10%) Pure red cell aplasia [3]
interactions with: acitretin, aprepitant,
Cardiovascular dofetilide, rosuvastatin, voriconazole
Flushing (<10%)
Renal
PROCARBAZINE Skin
Nephrotoxicity [3] See: www.drugeruptiondata.com/drug/id/580 Acneform eruption [3]
Hematologic Dermatitis [4]
Thrombocytopenia [2] Diaphoresis (31%)
Urticaria [2]
Cardiovascular
Flushing (12%)
Endocrine/Metabolic
Amenorrhea [2]
Litt’s Drug Eruption & Reaction Manual PROPRANOLOL
Mucosal Respiratory
PROMAZINE Oral lesions (>5%) Apnea [4]
Xerostomia (2%) Cough [2]
See: www.drugeruptiondata.com/drug/id/584 Hypoxia [7]
Cardiovascular
Bradycardia [3] Respiratory depression [2]
Brugada syndrome [7] Endocrine/Metabolic
PROMETHAZINE Cardiotoxicity [3] Acidosis [2]
Congestive heart failure [2] Renal
Trade name: Phenergan (Wyeth) Hypotension [3]
Indications: Allergic rhinitis, urticaria Green urine [8]
Class: Histamine H1 receptor antagonist Central Nervous System Local
Half-life: 1014 hours Dysgeusia (taste perversion) (323%) Infusion-related reactions [3]
Clinically important, potentially hazardous Seizures [3] Injection-site pain (>10%) [35]
interactions with: antihistamines, arsenic, Syncope [2]
Other
chlorpheniramine, dofetilide, nalbuphine, Gastrointestinal/Hepatic Adverse effects [4]
piperazine, quinolones, sparfloxacin, zaleplon Hepatotoxicity [8] Death [8]
Pregnancy category: C Local Hiccups [3]
Important contra-indications noted in the Injection-site pain (2890%) [4]
Note: Not for intra-arterial or subcutaneous PROPOXYPHENE
injection and contra-indicated in comatose states. PROPANTHELINE
Warning: RESPIRATORY DEPRESSION and See: www.drugeruptiondata.com/drug/id/589
SEVERE TISSUE INJURY, INCLUDING See: www.drugeruptiondata.com/drug/id/587
GANGRENE
PROPRANOLOL
Skin PROPOFOL
Dermatitis [3] Trade names: Hemangeol (Pierre Fabre), Inderal
Erythema multiforme [2] Trade name: Diprivan (AstraZeneca) (Wyeth)
Lupus erythematosus [2] Indications: Induction and maintenance of Indications: Hypertension, angina pectoris, atrial
Photosensitivity [12] anesthesia fibrillation, myocardial infarction, migraine,
Purpura [2] Class: Anesthetic, general tremor, infantile hemangioma
Toxic epidermal necrolysis [2] Half-life: initial: 40 minutes; terminal: 3 days Class: Antiarrhythmic, Antiarrhythmic class II,
Urticaria [3] Clinically important, potentially hazardous Beta adrenergic blocker, Beta blocker
interactions with: zinc Half-life: 26 hours
Mucosal Pregnancy category: B Clinically important, potentially hazardous
Xerostomia (<10%) [2] Important contra-indications noted in the interactions with: alcohol, aluminum hydroxide,
Cardiovascular prescribing guidelines for: nursing mothers; aminophylline, amiodarone, barbiturates,
QT prolongation [2] pediatric patients bupivacaine, chlorpromazine, cholestyramine,
Central Nervous System cimetidine, ciprofloxacin, clonidine, colestipol,
Neuroleptic malignant syndrome [2] Skin delavirdine, diazepam, dronedarone, epinephrine,
Seizures [2] Anaphylactoid reactions/Anaphylaxis ethanol, fluconazole, fluoxetine, fluvoxamine,
Somnolence (drowsiness) [3] (<10%) [8] haloperidol, imipramine, insulin, insulin detemir,
Angioedema [2] insulin glargine, insulin glulisine, isoniazid,
Exanthems (6%) [2] levothyroxine, lidocaine, neostigmine, nicardipine,
nifedipine, nilutamide, nisoldipine, oxtriphylline,
PROPAFENONE Rash (5%)
Urticaria [2] paroxetine hydrochloride, phenobarbital,
phenytoin, propafenone, pyridostigmine,
Trade name: Rythmol (Reliant) Hair quinidine, rifampin, ritonavir, rizatriptan, sodium
Indications: Ventricular arrhythmias Hair pigmentation [3] iodide I-131, teniposide, terbutaline, tolbutamide,
Class: Antiarrhythmic, Antiarrhythmic class Ic Cardiovascular verapamil, warfarin, zileuton, zolmitriptan
Half-life: 1032 hours Bradycardia [14] Pregnancy category: C
Clinically important, potentially hazardous Brugada syndrome [2] Important contra-indications noted in the
interactions with: amitriptyline, boceprevir, Cardiac failure [2] prescribing guidelines for: nursing mothers;
carvedilol, clozapine, cobicistat/elvitegravir/ Hypotension [17] pediatric patients
emtricitabine/tenofovir alafenamide, cobicistat/ Tachycardia [2] Note: Cutaneous side effects of beta-receptor
elvitegravir/emtricitabine/tenofovir disoproxil, blockers are clinically polymorphous. They
delavirdine, digoxin, efavirenz, fosamprenavir, Central Nervous System
Amnesia [10] apparently appear after several months of
grapefruit juice, mirabegron, neostigmine, continuous therapy.
paroxetine hydrochloride, propranolol, Hallucinations [3]
pyridostigmine, rifapentine, ritonavir, telaprevir, Seizures [8]
tipranavir Twitching (<10%) Skin
Pregnancy category: C Neuromuscular/Skeletal Acneform eruption [2]
Important contra-indications noted in the Ataxia [2] Angioedema [2]
prescribing guidelines for: nursing mothers; Rhabdomyolysis [9] Cold extremities [6]
pediatric patients Dermatitis [2]
Gastrointestinal/Hepatic Eczema [2]
Nausea [3] Exanthems [4]
Skin Pancreatitis [7] Lichenoid eruption [3]
Lupus erythematosus [3] Vomiting [4] Lupus erythematosus [2]
Psoriasis [2] Necrosis [3]
Rash (<3%)
PROPRANOLOL See all our books at www.crcpress.com
Pemphigus [2] Neuromuscular/Skeletal

Psoriasis [21] PROTAMINE SULFATE Arthralgia (4%)
Rash (<10%) [2] Gastrointestinal/Hepatic
Raynaud’s phenomenon [3] Indications: Heparin overdose
Class: Heparin antagonist Constipation (2%)
Stevens-Johnson syndrome [2] Nausea (4%)
Urticaria [3] Half-life: 2 hours
Clinically important, potentially hazardous Vomiting (4%)
Hair interactions with: none known Respiratory
Alopecia [6] Pregnancy category: C Dyspnea (2%)
Nails Hypoxia (2%)
Nail thickening [2] Skin Respiratory distress (2%)
Cardiovascular Anaphylactoid reactions/Anaphylaxis [42] Endocrine/Metabolic
Bradycardia [19] Angioedema [3] Hypokalemia (2%)
Cardiac arrest [2] Hypersensitivity [10] Hematologic
Flushing [2] Rash [2] Prothrombin time increased (3%)
Hypertension [2] Urticaria [5]
Hypotension [19] Cardiovascular
Central Nervous System Hypertension [2] PROTRIPTYLINE
Agitation [2] Hypotension [6]
Amnesia [2] Other See: www.drugeruptiondata.com/drug/id/594
Confusion [2] Adverse effects [2]
Delirium [3] Allergic reactions [13]
Hallucinations [5] Death [13]
Headache [2] PSEUDOEPHEDRINE
Insomnia [2]
Nightmares [2] Trade names: Allegra-D (Sanofi-Aventis),
Psychosis [3] PROTEIN C CONCEN- Benadryl (Pfizer), Bromfed (Muro), Entex
Sleep disturbances [9] (Andrx), Robitussin-CF (Wyeth), Sudafed (Pfizer),
Somnolence (drowsiness) [4] TRATE (HUMAN) Trinalin (Schering)
Vertigo (dizziness) [3] Indications: Nasal congestion
See: www.drugeruptiondata.com/drug/id/1247 Class: Adrenergic alpha-receptor agonist
Neuromuscular/Skeletal Half-life: 916 hours
Asthenia (fatigue) [4] Clinically important, potentially hazardous
PROTHROMBIN interactions with: bromocriptine, fluoxetine,
Gastrointestinal/Hepatic fluvoxamine, furazolidone, iobenguane, MAO
Constipation [2] COMPLEX inhibitors, paroxetine hydrochloride, phenelzine,
Diarrhea [6] rasagiline, sertraline, tranylcypromine
Gastroesophageal reflux [2] CONCENTRATE Pregnancy category: C
Nausea [2]
(HUMAN)
Respiratory Skin
Bronchospasm [3] Synonym: PCC AGEP [3]
Wheezing [3] Trade name: Kcentra (CSL Behring) Baboon syndrome (SDRIFE) [2]
Endocrine/Metabolic Indications: Urgent reversal of acquired Dermatitis [3]
Hyperkalemia [4] coagulation factor deficiency induced by vitamin K Diaphoresis (<10%)
Hypoglycemia [15] antagonist therapy in adult patients with acute Erythroderma [2]
Weight gain [2] major bleeding Exanthems [4]
Class: Coagulant Fixed eruption [14]
Genitourinary Half-life: 4–60 hours
Peyronie’s disease [6] Cardiovascular
Clinically important, potentially hazardous Myocardial infarction [2]
Ocular interactions with: none known Palpitation [2]
Hallucinations, visual [4] Pregnancy category: C
Other Somnolence (drowsiness) [2]
Adverse effects [10] prescribing guidelines for: nursing mothers;
Death [3] pediatric patients Ocular
Tooth decay [2] Warning: ARTERIAL AND VENOUS Hallucinations, visual [2]
THROMBOEMBOLIC COMPLICATIONS
PROPYLTHIOURACIL Skin PSORALENS

Hematoma (3%)
See: www.drugeruptiondata.com/drug/id/591 Trade names: Oxsoralen (Valeant), Trisoralen
Cardiovascular
(Valeant)
Hypertension (3%)
Indications: Psoriasis, eczema, vitiligo, cutaneous
Hypotension (5%)
T-cell lymphoma
PROPYPHENAZONE Orthostatic hypotension (4%)
Tachycardia (3%) Class: Psoralen
Half-life: 2 hours
See: www.drugeruptiondata.com/drug/id/1405 Central Nervous System Clinically important, potentially hazardous
Headache (8%) interactions with: none known
Intracranial hemorrhage (3%) Pregnancy category: C
Neurotoxicity (3%)
Litt’s Drug Eruption & Reaction Manual PYRIMETHAMINE
Skin
Anaphylactoid reactions/Anaphylaxis [2] PYRIDOSTIGMINE PYRIMETHAMINE
Basal cell carcinoma [3]
Bullous pemphigoid (with UVA) [13] Trade names: Mestinon (Valeant), Regonol Trade names: Daraprim (GSK), Fansidar (Roche)
Burning (<10%) [3] (Novartis) Indications: Malaria
Dermatitis [11] Indications: Myasthenia gravis Class: Antimalarial, Antiprotozoal
Eczema [2] Class: Acetylcholinesterase inhibitor Half-life: 8095 hours
Edema (<10%) Half-life: ~2 hours Clinically important, potentially hazardous
Ephelides (<10%) [5] Clinically important, potentially hazardous interactions with: dapsone, pemetrexed,
Erythema [2] interactions with: aminoglycosides, bacitracin, trimethoprim, zidovudine
Herpes simplex [2] clindamycin, colistin, edrophonium, polymyxin B, Pregnancy category: C
Herpes zoster [2] propafenone, propranolol, quinidine, tetracyclines Important contra-indications noted in the
Hypomelanosis (<10%) Pregnancy category: B prescribing guidelines for: the elderly; nursing
Lupus erythematosus [5] Important contra-indications noted in the mothers
Melanoma [3] prescribing guidelines for: nursing mothers; Note: Fansidar is pyrimethamine and sulfadoxine.
Photosensitivity [14] pediatric patients Sulfadoxine is a sulfonamide and can be absorbed
Phototoxicity [14] systemically. Sulfonamides can produce severe,
Pigmentation [9] Central Nervous System possibly fatal, reactions such as toxic epidermal
Porokeratosis (actinic) [3] Neurotoxicity [3] necrolysis and Stevens-Johnson syndrome.
Pruritus (>10%) [4] Parkinsonism [2]
Rash (<10%) Gastrointestinal/Hepatic Skin
Squamous cell carcinoma [4] Abdominal pain [5] Angioedema [2]
Tumors (for the most part malignant) [18] Diarrhea [2] Bullous dermatitis [2]
Vesiculation [2] Nausea [3] DRESS syndrome [2]
Vitiligo [2] Erythema multiforme [4]
Other Exanthems [3]
Hair Adverse effects [2]
Hypertrichosis [4] Exfoliative dermatitis [2]
Side effects [2] Fixed eruption [3]
Nails Hypersensitivity (>10%)
Nail pigmentation [4] Lichenoid eruption [2]
Photo-onycholysis [3] PYRIDOXINE Photosensitivity (>10%) [3]
Mucosal Pigmentation [5]
Cheilitis (<10%) See: www.drugeruptiondata.com/drug/id/598 Pruritus [2]
Central Nervous System Stevens-Johnson syndrome (<10%) [25]
Pain [3] Toxic epidermal necrolysis [15]
PYRILAMINE Central Nervous System
PYRAZINAMIDE See: www.drugeruptiondata.com/drug/id/599 Neuromuscular/Skeletal
See: www.drugeruptiondata.com/drug/id/597 Gastrointestinal/Hepatic
Diarrhea [2]
Nausea [2]
Vomiting [2]
Other
Adverse effects [2]
Death [4]
QUAZEPAM Over 100 updates per week on www.drugeruptiondata.com
Sedation [15] Skin

QUAZEPAM Seizures [7] Exanthems [3]
Serotonin syndrome [2] Exfoliative dermatitis (8%) [3]
See: www.drugeruptiondata.com/drug/id/601 Sleep related disorder [2] Fixed eruption [3]
Somnambulism [2] Lichenoid eruption (12%) [6]
Somnolence (drowsiness) (18%) [23] Ochronosis [2]
QUETIAPINE Suicidal ideation [3] Pigmentation [9]
Tardive dyskinesia (5%) [3] Squamous cell carcinoma [2]
Trade name: Seroquel (AstraZeneca) Tic disorder [3] Hair
Indications: Schizophrenia, bipolar I disorder Tremor [3] Alopecia (80%) [2]
Class: Antipsychotic, Mood stabilizer Vertigo (dizziness) (11%) [13]
Half-life: ~6 hours Nails
Neuromuscular/Skeletal Nail pigmentation (ala nasi) (blue-gray) [2]
Clinically important, potentially hazardous Asthenia (fatigue) (5%) [5]
interactions with: alcohol, amoxapine, Ataxia (2%) Mucosal
antihypertensive agents, arsenic, atazanavir, Dystonia [2] Oral pigmentation [4]
azithromycin, CNS acting drugs, darunavir, Pisa syndrome [2] Gastrointestinal/Hepatic
dolasetron, dopamine, drugs known to cause Rhabdomyolysis [4] Nausea [2]
electrolyte imbalance or increase QT interval, Vomiting [2]
erythromycin, fluconazole, hepatic enzyme Gastrointestinal/Hepatic
inducers, itraconazole, ketoconazole, levodopa, Abdominal pain (4–7%)
methadone, P4503A inhibitors, pazopanib, Colitis [3]
telavancin, tipranavir, tricyclic antidepressants, Constipation (8%) [4] QUINAGOLIDE
voriconazole Dyspepsia (5%)
Pregnancy category: C Hepatotoxicity [2] See: www.drugeruptiondata.com/drug/id/1377
Important contra-indications noted in the Nausea (7%)
prescribing guidelines for: the elderly; nursing Pancreatitis [4]
Vomiting (6%)
mothers; pediatric patients QUINAPRIL
Warning: INCREASED MORTALITY IN Respiratory
ELDERLY PATIENTS WITH DEMENTIA- Pneumonia [2] Trade names: Accupril (Pfizer), Accupro
RELATED PSYCHOSIS Endocrine/Metabolic (Pfizer), Accuretic (Pfizer)
SUICIDALITY AND ANTIDEPRESSANT DRUGS ALT increased (5%) Indications: Hypertension, heart failure
Appetite increased [3] Class: Angiotensin-converting enzyme (ACE)
Diabetes mellitus [2] inhibitor, Antihypertensive, Vasodilator
Skin
Hyperglycemia [3] Half-life: 2 hours
Diaphoresis (<10%)
Hypertriglyceridemia [3] Clinically important, potentially hazardous
Hyperhidrosis (2%)
Libido decreased (2%) interactions with: alcohol, aldesleukin,
Metabolic syndrome [2] allopurinol, alpha blockers, alprostadil, amifostine,
Rash (4%)
SIADH [2] amiloride, angiotensin II receptor antagonists,
Mucosal antacids, antidiabetics, antihypertensives,
Weight gain (5%) [23]
Sialorrhea [3] antipsychotics, anxiolytics and hypnotics,
Xerostomia (9%) [22] Genitourinary aprotinin, azathioprine, baclofen, beta blockers,
Priapism [14] calcium channel blockers, chlortetracycline,
Cardiovascular
Sexual dysfunction [2] ciprofloxacin, clonidine, corticosteroids,
Bradycardia [2]
Urinary retention [2] cyclosporine, demeclocycline, diazoxide,
Hypertension (41%)
Hypotension [6] Hematologic diuretics, doxycycline, eplerenone, estrogens,
Postural hypotension [2] Leukopenia [2] everolimus, gemifloxacin, general anesthetics,
QT prolongation [7] Neutropenia [2] gold & gold compounds, heparins, hydralazine,
Tachycardia (6%) [3] Thrombocytopenia [3] insulin, levodopa, lithium, lymecycline, MAO
Ocular inhibitors, metformin, methyldopa,
Amblyopia (2–3%) methylphenidate, minocycline, minoxidil,
Abnormal dreams (2–3%)
Vision blurred (<4%) moxifloxacin, moxisylyte, moxonidine, nitrates,
Agitation (20%) [2]
nitroprusside, NSAIDs, ofloxacin, oxytetracycline,
Akathisia (8%) [6] Other pentoxifylline, phosphodiesterase 5 inhibitors,
Anxiety (2–4%) Adverse effects [11] potassium salts, prostacyclin analogues, quinine,
Compulsions [3] Death [8] quinolones, rituximab, salicylates, sirolimus,
Confusion [2] Toothache (2–3%) spironolactone, sulfonylureas, temsirolimus,
Delirium [2]
tetracycline, tetracyclines, tigecycline, tizanidine,
Depression (3%) [3]
tolvaptan, triamterene, trimethoprim
Extrapyramidal symptoms [3]
Headache (21%) [6] QUINACRINE Pregnancy category: D (category C in first
trimester; category D in second and third
Hypoesthesia (2%)
Synonym: mepacrine trimesters)
Hypomania [3]
Trade name: Atabrine (Winthrop) Important contra-indications noted in the
Impulse control disorder [2]
Indications: Various infections caused by prescribing guidelines for: nursing mothers;
Insomnia (9%)
susceptible helminths pediatric patients
Mania [2]
Class: Antibiotic, Antimalarial Note: Contra-indicated in patients with a history
Half-life: 410 hours of angioedema related to previous treatment with
Pain (7%)
Clinically important, potentially hazardous an ACE inhibitor.
Paresthesias (3%)
interactions with: none known Warning: FETAL TOXICITY
Parkinsonism (4%) [4]
Psychosis [2]
Litt’s Drug Eruption & Reaction Manual QUINUPRISTIN/DALFOPRISTIN
Skin Skin Pregnancy category: C

Angioedema [9] Acneform eruption [2] Important contra-indications noted in the
Diaphoresis [3] AGEP [2] prescribing guidelines for: nursing mothers;
Edema [4] Dermatitis [4] pediatric patients
Peripheral edema [3] Exanthems [6] Note: Qualaquin (quinine sulfate) is not idicated
Photosensitivity [2] Exfoliative dermatitis [5] for the prevention or treatment of nocturnal leg
Pruritus [7] Fixed eruption [2] cramps.
Rash [5] Lichen planus [7] Contra-indicated in patients with prolongation of
Central Nervous System Lichenoid eruption [6] QT interval, G6PD deficiency, myasthenia gravis,
Dysgeusia (taste perversion) [3] Livedo reticularis [6] or optic neuritis.
Neuromuscular/Skeletal Photosensitivity [21]
Myalgia/Myopathy (2%) Skin
Pigmentation [3] Acneform eruption [2]
Respiratory Pruritus [3] Acral necrosis [2]
Cough [9] Psoriasis [5] Dermatitis [6]
Other Purpura [13] Erythema multiforme [2]
Adverse effects [2] Rash (<10%) Exanthems (<5%) [3]
Toxic epidermal necrolysis [2] Exfoliative dermatitis [2]
Vasculitis [5] Fixed eruption [12]
Mucosal Lichen planus [3]
QUINESTROL Oral mucosal eruption [2] Lichenoid eruption [3]
Cardiovascular Livedo reticularis (photosensitive) [3]
Congestive heart failure [2] Photosensitivity [19]
Flushing [2] Pigmentation [6]
QT prolongation [8] Purpura [13]
QUINETHAZONE Torsades de pointes [13] Raynaud’s phenomenon [2]
See: www.drugeruptiondata.com/drug/id/606 Central Nervous System Thrombocytopenic purpura [8]
Dysgeusia (taste perversion) (>10%) Toxic epidermal necrolysis [3]
Headache (<10%) Urticaria [2]
QUINIDINE Syncope [2] Vasculitis [5]
Tremor (2%)
Cardiovascular
Indications: Tachycardia, atrial fibrillation Gastrointestinal/Hepatic Cardiotoxicity [2]
Class: Antiarrhythmic, Antiarrhythmic class Ia, Diarrhea (>10%) [5]
Antimalarial, Antiprotozoal
Genitourinary Leg cramps [2]
Half-life: 68 hours Urinary tract infection [2]
Rhabdomyolysis [2]
interactions with: abarelix, afatinib, amiloride, Hematologic Endocrine/Metabolic
amiodarone, amisulpride, amitriptyline, Thrombocytopenia [2] Hypoglycemia [3]
amprenavir, anisindione, anticoagulants, Renal
aripiprazole, arsenic, artemether/lumefantrine, Nephrotoxicity [2]
asenapine, astemizole, atazanavir, boceprevir, QUININE Hematologic
celiprolol, ceritinib, ciprofloxacin, clevidipine,
clozapine, cobicistat/elvitegravir/emtricitabine/ Trade name: Qualaquin (URL Pharma) Hemolytic anemia [2]
tenofovir alafenamide, cobicistat/elvitegravir/ Indications: Malaria Hemolytic uremic syndrome [16]
emtricitabine/tenofovir disoproxil, crizotinib, Class: Antimalarial, Antiprotozoal Thrombocytopenia [11]
dabigatran, darunavir, dasatinib, degarelix, Half-life: 814 hours Thrombotic microangiopathy [2]
delavirdine, deutetrabenazine, dicumarol, digoxin, Clinically important, potentially hazardous Otic
duloxetine, eluxadoline, enoxacin, enzalutamide, interactions with: amantadine, amiodarone, Hearing loss [4]
ethoxzolamide, fosamprenavir, gatifloxacin, amitriptyline, amoxapine, anisindione, Ototoxicity [2]
glycopyrrolate, glycopyrronium, indinavir, anticoagulants, arsenic, artemether/lumefantrine, Tinnitus [9]
itraconazole, ketoconazole, lomefloxacin, astemizole, atazanavir, atorvastatin, cimetidine, Ocular
lopinavir, lurasidone, metformin, mifepristone, cisapride, citalopram, class Ia or III Amblyopia [8]
mivacurium, moxifloxacin, naldemedine, antiarrhythmics, clevidipine, CYP3A4 and
nelfinavir, nilotinib, norfloxacin, ofloxacin, CYP2D6 substrates, CYP3A4 inducers or Other
osimertinib, oxprenolol, pimavanserin, pimozide, inhibitors, darunavir, dasatinib, degarelix, Adverse effects [3]
pipecuronium, posaconazole, pristinamycin, dicumarol, digoxin, disopyramide, dofetilide, Death [2]
propranolol, pyridostigmine, quinine, quinolones, dolasetron, droperidol, enalapril, flecainide,
ranolazine, ribociclib, rifapentine, ritonavir, fosamprenavir, halofantrine, haloperidol,
rocuronium, sertindole, sotalol, sparfloxacin, histamine, indinavir, lapatinib, levofloxacin, QUINUPRISTIN/
sulpiride, telaprevir, telithromycin, tetrabenazine, mefloquine, metformin, moxifloxacin, nelfinavir,
tipranavir, tramadol, valbenazine, vecuronium, neuromuscular blocking agents, olmesartan, oral DALFOPRISTIN
venetoclax, verapamil, voriconazole, vortioxetine, typhoid vaccine, pazopanib, pimozide,
warfarin, zuclopenthixol procainamide, prochlorperazine, quinapril, See: www.drugeruptiondata.com/drug/id/609
Pregnancy category: C quinidine, ramipril, rifampin, ritonavir, saquinavir,
Important contra-indications noted in the sotalol, succinylcholine, telavancin, telithromycin,
prescribing guidelines for: nursing mothers; terfenadine, tipranavir, voriconazole, vorinostat,
pediatric patients warfarin, ziprasidone
RABEPRAZOLE See all our books at www.crcpress.com
Neuromuscular/Skeletal Sinusitis (10%)

RABEPRAZOLE Bone or joint pain [3] Endocrine/Metabolic
Trade name: Aciphex (Eisai) (Janssen) Gastrointestinal/Hepatic Mastodynia (4%) [2]
Indications: Gastroesophageal reflux disease Diarrhea (25%) [6] Weight gain (9%)
(GERD), duodenal ulcers, Zollinger-Ellison Nausea (36%) [5] Genitourinary
syndrome Vomiting (19%) [4] Vaginal bleeding (6%)
Class: Proton pump inhibitor (PPI) Endocrine/Metabolic Vaginitis (4%)
Half-life: 1–2 hours Dehydration (3%) Hematologic
Clinically important, potentially hazardous Renal Thrombosis [2]
interactions with: atazanavir, clopidogrel, Renal failure (3%)
cyclosporine, digoxin, ketoconazole, rilpivirine, Other
Renal function abnormal (<3%) Adverse effects [2]
simvastatin, warfarin
Pregnancy category: B Hematologic Infection (11%)
Important contra-indications noted in the Anemia (93%) [7]
prescribing guidelines for: nursing mothers Leukopenia (35%) [3]
Lymphocytopenia (72%) [3]
Myelosuppression [2]
RALTEGRAVIR
Skin Neutropenia (18%) [6]
Pruritus [2] Trade name: Isentress (Merck)
Pancytopenia (2%) Indications: HIV-1 infection
Rash [2] Thrombocytopenia (31%) [6] Class: Antiretroviral, Integrase strand transfer
Central Nervous System Other inhibitor
Dysgeusia (taste perversion) [2] Adverse effects [2] Half-life: 9 hours
Headache (2–5%) [4] Clinically important, potentially hazardous
Pain (3%) interactions with: atazanavir, efavirenz,
Vertigo (dizziness) [4] histamine H2 antagonists, omeprazole,
RALOXIFENE pantoprazole, proton pump inhibitors, rifampin,
Asthenia (fatigue) [3] Trade name: Evista (Lilly) St John’s wort, strong UGT inducers, tipranavir
Gastrointestinal/Hepatic Indications: Osteoporosis, reduction in risk of Pregnancy category: C
Abdominal pain [6] invasive breast cancer in postmenopausal women Important contra-indications noted in the
Constipation (2%) with osteoporosis or at high risk for invasive prescribing guidelines for: nursing mothers;
Diarrhea (3%) [8] breast cancer pediatric patients
Dyspepsia [3] Class: Selective estrogen receptor modulator
Flatulence [2] (SERM) Skin
Gastrointestinal bleeding [2] Half-life: 27.7 hours DRESS syndrome [4]
Nausea [5] Clinically important, potentially hazardous Herpes zoster (<2%)
Vomiting [5] interactions with: cholestyramine, Hypersensitivity (<2%) [7]
Respiratory levothyroxine Pruritus (4%)
Cough [3] Pregnancy category: X Rash [8]
Upper respiratory tract infection [2] Important contra-indications noted in the Central Nervous System
prescribing guidelines for: nursing mothers; Depression (<2%) [2]
Endocrine/Metabolic pediatric patients
Hypomagnesemia [2] Headache (2%) [9]
Warning: INCREASED RISK OF VENOUS Insomnia (4%) [4]
Renal THROMBOEMBOLISM AND DEATH FROM Neurotoxicity [2]
Nephrotoxicity [2] STROKE Vertigo (dizziness) (<2%)
Other Neuromuscular/Skeletal
Adverse effects [4] Skin Asthenia (fatigue) (<2%) [4]
Diaphoresis (3%) Myalgia/Myopathy [3]
Hot flashes (8–29%) [14] Rhabdomyolysis [8]
RADIUM-223 Peripheral edema (35%) [4]
Rash (6%) Gastrointestinal/Hepatic
Abdominal pain (<2%) [2]
DICHLORIDE Cardiovascular Diarrhea [7]
Chest pain (3%) Dyspepsia (<2%)
Synonym: Ra-223 dichloride Venous thromboembolism [5] Gastritis (<2%)
Trade name: Xofigo (Bayer)
Central Nervous System Hepatitis [2]
Indications: Castration-resistant prostate cancer
Insomnia (6%) Hepatotoxicity (<2%) [3]
Class: Radiopharmaceutical, alpha-emitting
Stroke [4] Nausea (<2%) [8]
Half-life: 11.4 days
Neuromuscular/Skeletal Vomiting (<2%)
interactions with: none known Arthralgia (11–16%) Endocrine/Metabolic
Pregnancy category: X Leg cramps (6–12%) [5] ALT increased [3]
Important contra-indications noted in the Myalgia/Myopathy (8%) Creatine phosphokinase increased [3]
prescribing guidelines for: nursing mothers; Gastrointestinal/Hepatic Renal
pediatric patients Abdominal pain (7%) Nephrolithiasis (<2%)
Vomiting (5%) Renal failure (<2%)
Skin Respiratory Other
Peripheral edema (13%) [3] Bronchitis (10%) Adverse effects [6]
Central Nervous System Flu-like syndrome (~2%)
Anorexia [2] Pharyngitis (8%)
Pneumonia (3%)
Litt’s Drug Eruption & Reaction Manual RANIBIZUMAB
quinine, rituximab, sirolimus, spironolactone, Rash (4%)

RALTITREXED sulfonylureas, telmisartan, temsirolimus, Mucosal
tizanidine, tolvaptan, triamterene, trimethoprim Epistaxis (nosebleed) (5%) [2]
See: www.drugeruptiondata.com/drug/id/1298 Pregnancy category: D (category C in first Stomatitis [3]
trimester; category D in second and third
trimesters) Cardiovascular
RAMELTEON Important contra-indications noted in the Hypertension (16%) [21]
prescribing guidelines for: nursing mothers; Thromboembolism (2%) [2]
Trade name: Rozerem (Takeda) pediatric patients Venous thromboembolism [2]
Indications: Insomnia Note: Contra-indicated in patients with a history Central Nervous System
Class: Hypnotic, Melatonin receptor agonist of angioedema related to previous treatment with Anorexia [2]
Half-life: 12.6 hours an ACE inhibitor, or a history of hereditary or Headache (9%) [3]
Clinically important, potentially hazardous idiopathic angioedema. Neuromuscular/Skeletal
interactions with: alcohol, antifungals, CNS Warning: FETAL TOXICITY Asthenia (fatigue) [13]
depressants, conivaptan, CYP1A2 inhibitors,
donepezil, doxepin, droperidol, fluconazole, Gastrointestinal/Hepatic
Skin Abdominal pain [2]
fluvoxamine, food, ketoconazole, Angioedema [11]
levomepromazine, rifampin, rifapentine, St John’s Ascites [2]
Diaphoresis [2] Constipation [3]
wort, voriconazole, zolpidem Lichen planus pemphigoides [3]
Pregnancy category: C Diarrhea (14%) [7]
Photosensitivity [2] Gastric obstruction (2%)
Important contra-indications noted in the Pruritus [3]
prescribing guidelines for: nursing mothers; Gastrointestinal perforation [4]
Rash [4] Hepatotoxicity [2]
pediatric patients
Hair Nausea [4]
Alopecia (<10%) Vomiting [4]
Depression (2%) Cardiovascular Respiratory
Dysgeusia (taste perversion) (2%) Angina (3%) Dyspnea [3]
Headache (7%) [8] Flushing [2] Endocrine/Metabolic
Insomnia (exacerbation) (3%) Hypotension (11%) [3] Appetite decreased [2]
Somnolence (drowsiness) (3%) [9] Postural hypotension (2%) Hyponatremia (6%)
Vertigo (dizziness) (4%) [6] Central Nervous System Renal
Neuromuscular/Skeletal Headache (5%) [2] Proteinuria [10]
Arthralgia (2%) Syncope (2%)
Vertigo (dizziness) (2–4%) [4] Hematologic
Asthenia (fatigue) (3%) [4] Anemia [5]
Myalgia/Myopathy (2%) Neuromuscular/Skeletal Bleeding [5]
Gastrointestinal/Hepatic Asthenia (fatigue) (2%) Febrile neutropenia [9]
Nausea (3%) [3] Gastrointestinal/Hepatic Hemorrhage [3]
Respiratory Hepatotoxicity [2] Leukopenia [6]
Upper respiratory tract infection (3%) Nausea (2%) Neutropenia (5%) [12]
Pancreatitis [2] Thrombocytopenia [5]
Genitourinary Vomiting (2%)
Urinary tract infection [2] Local
Respiratory Infusion-related reactions [4]
Other Cough (8–12%) [22]
Adverse effects [7] Other
Endocrine/Metabolic Adverse effects [2]
Hyperkalemia [2] Death [3]
RAMIPRIL Other
Adverse effects [4]
Trade names: Altace (Monarch), Tritace (Sanofi- RANIBIZUMAB
Aventis)
Indications: Hypertension RAMUCIRUMAB Trade name: Lucentis (Genentech)
Indications: Neovascular (wet) age-related
Class: Angiotensin-converting enzyme (ACE)
inhibitor, Antihypertensive, Vasodilator Trade name: Cyramza (Lilly) macular degeneration, macular edema (following
Half-life: 2–17 hours Indications: Gastric cancer retinal vein occlusion)
Clinically important, potentially hazardous Class: Monoclonal antibody, Vascular endothelial Class: Monoclonal antibody, Vascular endothelial
interactions with: alcohol, aldesleukin, growth factor antagonist growth factor antagonist
allopurinol, alpha blockers, alprostadil, amifostine, Half-life: N/A Half-life: 9 days
amiloride, angiotensin II receptor antagonists, Clinically important, potentially hazardous Clinically important, potentially hazardous
antacids, antihypertensives, antipsychotics, interactions with: none known interactions with: none known
azathioprine, baclofen, beta blockers, calcium Pregnancy category: C Pregnancy category: C
channel blockers, clonidine, corticosteroids, Important contra-indications noted in the Important contra-indications noted in the
cyclosporine, diazoxide, diuretics, eplerenone, prescribing guidelines for: nursing mothers; prescribing guidelines for: nursing mothers;
estrogens, everolimus, general anesthetics, gold & pediatric patients pediatric patients
gold compounds, heparins, hydralazine, Warning: HEMORRHAGE, GASTROINSTINAL Note: Contra-indicated in patients with ocular or
hypotensives, insulin, levodopa, lithium, MAO PERFORATION, AND IMPAIRED WOUND periocular infections.
inhibitors, metformin, methyldopa, minoxidil, HEALING
moxisylyte, moxonidine, nitrates, nitroprusside, Cardiovascular
NSAIDs, pentoxifylline, phosphodiasterase 5 Skin Atrial fibrillation (<5%)
inhibitors, potassium salts, prostacyclin analogues, Peripheral edema [2] Hypertension [4]
RANIBIZUMAB Over 100 updates per week on www.drugeruptiondata.com
Myocardial infarction [2] Cardiovascular

Thromboembolism [3] RANITIDINE Palpitation (<2%)
Central Nervous System QT prolongation [7]
Trade name: Zantac (Concordia) Torsades de pointes [2]
Anxiety (<4%) Indications: Duodenal ulcer
Headache (3–12%) Class: Histamine H2 receptor antagonist Central Nervous System
Insomnia (<5%) Half-life: 2.5 hours Headache (3%) [4]
Stroke [3] Clinically important, potentially hazardous Vertigo (dizziness) [10]
Neuromuscular/Skeletal interactions with: alfentanil, delavirdine, Neuromuscular/Skeletal
Arthralgia (2–11%) fentanyl, gefitinib, metformin, prednisone, Asthenia (fatigue) [3]
Pain in extremities (<5%) rilpivirine, risperidone Gastrointestinal/Hepatic
Gastrointestinal/Hepatic Pregnancy category: B Abdominal pain (<2%)
Gastroenteritis (<4%) Important contra-indications noted in the Constipation [8]
Nausea (<9%) prescribing guidelines for: nursing mothers Nausea [9]
Respiratory Vomiting [2]
Bronchitis (<12%) Skin Otic
COPD (<7%) AGEP [2] Tinnitus (<2%)
Cough (2–9%) Anaphylactoid reactions/Anaphylaxis [18]
Dyspnea (<5%) Dermatitis [6]
Influenza (3–7%) Eczema [2]
Nasopharyngitis (5–16%) [2] Exanthems [5] RAPACURONIUM
Sinusitis (3–8%) Hypersensitivity [2]
Photosensitivity [2] See: www.drugeruptiondata.com/drug/id/806
Pseudolymphoma [2]
Endocrine/Metabolic Purpura [2]
Hypercholesterolemia (<5%) Rash (<10%) RASAGILINE
Genitourinary Toxic epidermal necrolysis [2]
Urinary tract infection (<9%) Urticaria [4] Trade name: Azilect (Teva)
Hematologic Central Nervous System Indications: Parkinsonism
Anemia (<8%) Confusion [2] Class: Monoamine oxidase B inhibitor
Somnolence (drowsiness) [2] Half-life: 0.62.0 hours
Blepharitis (<13%) Respiratory interactions with: aminophylline, amitriptyline,
Cataract (2–17%) [4] Pneumonia [2] ciprofloxacin, citalopram, dextromethorphan,
Conjunctival hemorrhage (48–74%) [4] Endocrine/Metabolic entacapone, fluoxetine, fluvoxamine, MAO
Conjunctival hyperemia (<8%) Gynecomastia [3] inhibitors, meperidine, paroxetine hydrochloride,
Endophthalmitis [9] Porphyria [3] pethidine, pseudoephedrine, SSRIs
Hallucinations, visual [2] Pregnancy category: C
Intraocular inflammation (<18%) [5] Other
Adverse effects [3] Important contra-indications noted in the
Intraocular pressure increased (7–24%) [7] prescribing guidelines for: nursing mothers;
Iridocyclitis [2] pediatric patients
Lacrimation (increased) (2–14%)
Maculopathy (6–11%) RANOLAZINE Skin
Ocular adverse effects [3]
Ocular hemorrhage [5] Trade name: Ranexa (CV Therapeutics) Ecchymoses (2%)
Ocular hyperemia (5–11%) Indications: Angina Mucosal
Ocular pain (17–35%) [3] Class: Anti-ischemic, Fatty acid oxidation Xerostomia (3%)
Ocular pruritus (<12%) inhibitor Cardiovascular
Ocular stinging (7–15%) Half-life: 7 hours Hypotension (5%)
Posterior capsule opacification (<8%) Clinically important, potentially hazardous
Retinal atrophy [2] interactions with: aprepitant, atazanavir, Central Nervous System
Retinal detachment [2] clarithromycin, conivaptan, cyclosporine, CYP3A Depression (5%) [2]
Retinal vein occlusion [2] inducers, CYP3A inhibitors, darunavir, dasabuvir/ Dyskinesia (>10%)
Vision blurred (5–18%) ombitasvir/paritaprevir/ritonavir, delavirdine, Fever (3%)
Visual disturbances (5–18%) diltiazem, dofetilide, efavirenz, erythromycin, Gait instability (5%)
Vitreous detachment (4–21%) grapefruit juice, indinavir, itraconazole, Headache (14%) [2]
Vitreous floaters (7–27%) [2] ketoconazole, lopinavir, nelfinavir, ombitasvir/ Paresthesias (2%)
Xerophthalmia (3–12%) paritaprevir/ritonavir, oxcarbazepine, paroxetine Somnolence (drowsiness) [3]
hydrochloride, phenobarbital, quinidine, rifampin, Vertigo (dizziness) (2%) [3]
Local
Injection-site bleeding (<6%) rifapentine, ritonavir, simvastatin, sotalol, Neuromuscular/Skeletal
telithromycin, thioridazine, tipranavir, venetoclax, Arthralgia (7%) [2]
Other verapamil, voriconazole, ziprasidone Asthenia (fatigue) (2%)
Adverse effects [5] Pregnancy category: C Dystonia (2%)
Systemic reactions [2] Important contra-indications noted in the Neck pain (2%)
prescribing guidelines for: nursing mothers Gastrointestinal/Hepatic
Note: Contra-indicated in patients with existing
Dyspepsia (7%)
QT prolongation, and in patients with liver
Gastroenteritis (3%)
disease.
Nausea [2]
Respiratory
Mucosal Flu-like syndrome (5%)
Xerostomia (<2%)
Litt’s Drug Eruption & Reaction Manual RIBAVIRIN
Rhinitis (3%) Photosensitivity [6]

Ocular
RESLIZUMAB Pruritus [O] (13–29%) [26]
Conjunctivitis (3%) Psoriasis [2]
Trade name: Cinqair (Teva) Rash [O] (5–28%) [38]
Indications: Adjunctive treatment for severe Sarcoidosis [16]
eosinophilic asthma Stevens-Johnson syndrome [2]
RASBURICASE Class: Interleukin-5 antagonist, Monoclonal Toxic epidermal necrolysis [2]
antibody Toxicity [2]
See: www.drugeruptiondata.com/drug/id/942 Half-life: 24 days Vasculitis [2]
Clinically important, potentially hazardous Vitiligo [2]
interactions with: none known Xerosis [O] (10–24%) [2]
REBOXETINE Pregnancy category: N/A (Insufficient evidence
to inform drug-associated risk) Hair
Important contra-indications noted in the Alopecia [O] (27–36%) [5]
Trade name: Edronax (Pfizer) Alopecia areata [2]
Indications: Clinical depression, panic disorder prescribing guidelines for: nursing mothers;
Class: Antidepressant, Noradrenaline reuptake pediatric patients Cardiovascular
inhibitor Warning: ANAPHYLAXIS Flushing [O] (4%)
Clinically important, potentially hazardous Mucosal Depression [O] (20–36%) [10]
interactions with: azithromycin, bosentan, Oropharyngeal pain (3%) Dysgeusia (taste perversion) [O] (4–9%) [4]
itraconazole, ketoconazole, MAO inhibitors, Central Nervous System Fever [O] (32–55%) [7]
papaverine, voriconazole Headache [3] Headache [INH] ( Insomnia [O] (25–41%)
Pregnancy category: N/A (not recommended [26]
in pregnancy) Respiratory Irritability [9]
Important contra-indications noted in the Asthma (exacerbation) [3] Neurotoxicity [2]
prescribing guidelines for: the elderly; nursing Nasopharyngitis [4] Pain [O] (10%)
mothers; pediatric patients Upper respiratory tract infection [3] Rigors [O] (25–48%)
Endocrine/Metabolic Suicidal ideation [O] (2%) [2]
Skin Creatine phosphokinase increased (14%) Vertigo (dizziness) [O] (14–26%) [6]
Diaphoresis [8] Neuromuscular/Skeletal
Mucosal Arthralgia [INH] (22–34%) [7]
Xerostomia [12] RETAPAMULIN Asthenia (fatigue) [59]
Muscle spasm [3]
Central Nervous System See: www.drugeruptiondata.com/drug/id/1248 Myalgia/Myopathy [INH] (40–64%) [4]
Headache [5]
Insomnia [9] Gastrointestinal/Hepatic
Somnolence (drowsiness) [2] Diarrhea [16]
Genitourinary
RETEPLASE Hepatotoxicity [6]
Nausea [INH] (<10%) [37]
Ejaculatory dysfunction [2] See: www.drugeruptiondata.com/drug/id/616 Pancreatitis [4]
Vomiting [O] (9–25%) [3]
Respiratory
REGADENOSON RIBAVIRIN Cough [O] (7–23%) [9]
Dyspnea [O] (13–26%) [5]
See: www.drugeruptiondata.com/drug/id/1293 Trade names: Copegus (Roche), Rebetol Flu-like syndrome [O] (13–18%) [8]
(Schering-Plough), Rebetron (Schering), Virazole Nasopharyngitis [3]
(Valeant) Pneumonitis [2]
REGORAFENIB Indications: Respiratory syncytial viral infections Rhinitis [O] (8%)
Class: Antiviral, nucleoside analog Upper respiratory tract infection [3]
See: www.drugeruptiondata.com/drug/id/3067 Half-life: 24 hours Endocrine/Metabolic
Clinically important, potentially hazardous ALT increased [6]
interactions with: abacavir, azathioprine, Appetite decreased [2]
REMIFENTANIL didanosine, emtricitabine, interferon alfa, PEG-
interferon, stavudine, zidovudine
AST increased [5]
See: www.drugeruptiondata.com/drug/id/1414 Pregnancy category: X Hyperbilirubinemia [3]
Important contra-indications noted in the Hyperuricemia [O] (33–38%)
prescribing guidelines for: nursing mothers Thyroid dysfunction [2]
Note: [INH] = Inhalation; [O] = Oral. Rebetron
REPAGLINIDE is ribavirin and interferon.
Weight loss [O] (10–29%) [2]
Warning: RISK OF SERIOUS DISORDERS AND Genitourinary
See: www.drugeruptiondata.com/drug/id/614 RIBAVIRIN-ASSOCIATED EFFECTS Erectile dysfunction [2]
Renal
Skin Nephrotoxicity [5]
RESERPINE Dermatitis [O] (16%) Hematologic
DRESS syndrome [2] Anemia [INH] (<10%) [74]
See: www.drugeruptiondata.com/drug/id/615 Eczema [O] (4–5%) [3] Hemoglobin decreased [3]
Exanthems [5] Hemotoxicity [2]
Lichenoid eruption [2] Leukopenia [O] (6–45%) [3]
Nummular eczema [2] Lymphopenia [O] (12–14%) [2]
Peripheral edema [2] Neutropenia [O] (8–42%) [18]
RIBAVIRIN See all our books at www.crcpress.com
Thrombocytopenia [INH] (<15%) [10] Endocrine/Metabolic Diarrhea (3%)

Otic ALT increased (46%) Dyspepsia (3%)
Hearing loss [2] Appetite decreased (19%) Eructation (belching) (3%)
Tinnitus [2] AST increased (44%) Flatulence (2%)
Hyperbilirubinemia (18%) Hepatotoxicity [2]
Ocular Serum creatinine increased (20%) Nausea (6%)
Retinopathy [6]
Genitourinary Ocular
Local Urinary tract infection (11%) Intraocular inflammation [2]
Injection-site reactions [2] Ocular toxicity [2]
Hematologic
Other Anemia (18%) Uveitis [31]
Adverse effects [24] Leukopenia (33%) [5] Visual disturbances [2]
Death [4] Lymphopenia (11%) [2]
Infection [INH] [4] Neutropenia (75%) [8]
Vogt-Koyanagi-Harada syndrome [6] RIFAMPIN
Synonym: rifampicin
RIBOCICLIB * RIBOFLAVIN Trade names: Rifadin (Sanofi-Aventis),
See: www.drugeruptiondata.com/drug/id/618 Rimactane (Novartis)
Trade name: Kisqali (Novartis) Indications: Tuberculosis
Indications: Treatment of postmenopausal Class: Antibiotic, rifamycin, CYP1A2 inducer,
women with hormone receptor (HR)-positive, CYP3A4 inducer
human epidermal growth factor receptor 2 RIFABUTIN Half-life: 35 hours
(HER2)-negative advanced or metastatic breast Clinically important, potentially hazardous
cancer (in combination with an aromatase Trade name: Mycobutin (Pfizer) interactions with: abacavir, abiraterone, afatinib,
inhibitor) Indications: Disseminated Mycobacterium avium amiodarone, amprenavir, anisindione, antacids,
Class: Kinase inhibitor infection anticoagulants, apixaban, apremilast, aprepitant,
Half-life: 30–55 hours Class: Antibiotic, rifamycin, CYP3A4 inducer artemether/lumefantrine, atazanavir, atorvastatin,
Clinically important, potentially hazardous Half-life: 45 hours atovaquone, atovaquone/proguanil,
interactions with: alfentanil, amiodarone, Clinically important, potentially hazardous beclomethasone, bedaquiline, betamethasone,
bepridil, boceprevir, chloroquine, clarithromycin, interactions with: abiraterone, amiodarone, bisoprolol, boceprevir, bosentan, brentuximab
conivaptan, cyclosporine, CYP3A4 substrates, amprenavir, anisindione, anticoagulants, vedotin, brigatinib, brivaracetam, buprenorphine,
dihydroergotamine, disopyramide, ergotamine, atazanavir, atovaquone, atovaquone/proguanil, cabazitaxel, cabozantinib, canagliflozin,
everolimus, fentanyl, grapefruit juice, halofantrine, azithromycin, bedaquiline, boceprevir, caspofungin, ceritinib, clobazam, clozapine,
haloperidol, indinavir, itraconazole, ketoconazole, cabazitaxel, cabozantinib, cobicistat/elvitegravir/ cobimetinib, copanlisib, corticosteroids,
lopinavir, methadone, midazolam, moxifloxacin, emtricitabine/tenofovir alafenamide, cobicistat/ cortisone, crizotinib, cyclosporine, cyproterone,
ondansetron, pimozide, procainamide, QT elvitegravir/emtricitabine/tenofovir disoproxil, dabigatran, daclatasvir, dapsone, darunavir,
prolonging drugs, quinidine, rifampin, ritonavir, corticosteroids, crizotinib, cyclosporine, dapsone, dasabuvir/ombitasvir/paritaprevir/ritonavir,
saquinavir, sirolimus, sotalol, strong CYP3A4 darunavir, delavirdine, dicumarol, efavirenz, dasatinib, deferasirox, deflazacort, delavirdine,
inducers and inhibitors, tacrolimus, voriconazole enzalutamide, etravirine, flibanserin, dexamethasone, diclofenac, dicumarol, digoxin,
Pregnancy category: N/A (Can cause fetal fosamprenavir, indinavir, itraconazole, doxycycline, dronedarone, edoxaban, efavirenz,
harm) ixabepilone, lapatinib, ledipasvir & sofosbuvir, elbasvir & grazoprevir, eliglustat, eluxadoline,
Important contra-indications noted in the levonorgestrel, lopinavir, midazolam, emtricitabine/rilpivirine/tenofovir alafenamide,
prescribing guidelines for: nursing mothers; mifepristone, nelfinavir, oral contraceptives, enzalutamide, estradiol, eszopiclone, etoricoxib,
pediatric patients posaconazole, rilpivirine, ritonavir, romidepsin, etravirine, everolimus, fesoterodine, flibanserin,
simeprevir, sofosbuvir, sofosbuvir & velpatasvir, fludrocortisone, flunisolide, fosamprenavir,
sofosbuvir/velpatasvir/voxilaprevir, solifenacin, gadoxetate, gefitinib, gestrinone, glecaprevir &
Skin sonidegib, sorafenib, sunitinib, tacrolimus,
Peripheral edema (12%) pibrentasvir, halothane, hydrocortisone, ibrutinib,
temsirolimus, tenofovir alafenamide, thalidomide, idelalisib, imatinib, indinavir, isavuconazonium
Pruritus (14%) tipranavir, tolvaptan, vandetanib, vemurafenib,
Rash (17%) sulfate, isoniazid, itraconazole, ixabepilone,
voriconazole ixazomib, ketoconazole, lapatinib, ledipasvir &
Hair Pregnancy category: B sofosbuvir, leflunomide, lesinurad, levodopa,
Alopecia (33%) Important contra-indications noted in the levonorgestrel, linagliptin, linezolid, lopinavir,
Mucosal prescribing guidelines for: the elderly; nursing lorcainide, losartan, lumacaftor/ivacaftor,
Stomatitis (12%) mothers; pediatric patients lurasidone, macitentan, maraviroc,
methylprednisolone, midazolam, midostaurin,
Skin mifepristone, naldemedine, nelfinavir, neratinib,
Fever (13%)
Lupus erythematosus [2] netupitant & palonosetron, nevirapine, nifedipine,
Headache (22%)
Pigmentation [2] nilotinib, olaparib, ombitasvir/paritaprevir/
Insomnia (12%)
Rash (11%) [2] ritonavir, ondansetron, oral contraceptives,
Neuromuscular/Skeletal osimertinib, ospemifene, oxtriphylline, paclitaxel,
Asthenia (fatigue) (37%) [3] Central Nervous System
palbociclib, pazopanib, perampanel,
Back pain (20%) Anorexia (2%)
phenylbutazone, pimavanserin, pioglitazone,
Gastrointestinal/Hepatic pitavastatin, pomalidomide, ponatinib,
Fever (2%)
Abdominal pain (11%) praziquantel, prednisolone, prednisone,
Headache (3%)
Constipation (25%) propranolol, propyphenazone, protease
Diarrhea (35%) Neuromuscular/Skeletal inhibitors, pyrazinamide, quinine, raltegravir,
Nausea (52%) [5] Arthralgia [6] ramelteon, ranolazine, regorafenib, ribociclib,
Vomiting (29%) [2] Myalgia/Myopathy (2%) rilpivirine, riociguat, ritonavir, rivaroxaban,
Gastrointestinal/Hepatic roflumilast, romidepsin, rosiglitazone, saquinavir,
Respiratory
Abdominal pain (4%) simeprevir, simvastatin, sofosbuvir, sofosbuvir &
Dyspnea (12%)
Litt’s Drug Eruption & Reaction Manual RILUZOLE
velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, Gastrointestinal/Hepatic

solifenacin, sonidegib, sorafenib, sunitinib, RIFAPENTINE Abdominal distension (<8%)
tacrolimus, tadalafil, tasimelteon, telaprevir, Abdominal pain (2–9%) [10]
telithromycin, temsirolimus, tenofovir See: www.drugeruptiondata.com/drug/id/621 Ascites (11%)
alafenamide, terbinafine, thalidomide, ticagrelor, Black stools (<2%)
tipranavir, tofacitinib, tolvaptan, trabectedin, Constipation (4–6%)
treprostinil, triamcinolone, triazolam, RIFAXIMIN Diarrhea (<2%) [6]
trimethoprim, troleandomycin, ulipristal, Fecal urgency (6%)
valbenazine, vandetanib, vemurafenib, venetoclax, Trade names: Xifaxan (Salix), Xifaxanta Flatulence (11%) [2]
vorapaxar, voriconazole, vortioxetine, warfarin, (Norgine) Hernia (<2%)
zaleplon, zidovudine, zolpidem Indications: Diarrhea in travelers (caused by Nausea (5–14%) [8]
Pregnancy category: C non-invasive strains of E. coli), reduction in risk of Tenesmus (7%)
overt hepatic encephalopathy recurrence (in Vomiting (2%) [3]
Skin adults) Respiratory
Acneform eruption [3] Class: Antibiotic, rifamycin Cough (7%)
AGEP [2] Half-life: 2–5 hours Dyspnea (<6%)
Anaphylactoid reactions/Anaphylaxis [8] Clinically important, potentially hazardous Flu-like syndrome (2–5%)
Dermatitis [3] interactions with: BCG vaccine Nasopharyngitis (<7%) [4]
Diaphoresis (<10%) Pregnancy category: C Pharyngitis (<2%)
DRESS syndrome [5] Important contra-indications noted in the Pharyngolaryngeal pain (<2%)
Erythema multiforme [4] prescribing guidelines for: nursing mothers; Pneumonia (2–5%)
Exanthems (<5%) [6] pediatric patients Rhinitis (<5%)
Fixed eruption [6] Sinusitis [2]
Hypersensitivity [5] Skin Upper respiratory tract infection (2–5%) [6]
Linear IgA bullous dermatosis [3] Cellulitis (2–5%) Endocrine/Metabolic
Pemphigus [9] Clammy skin (<2%) AST increased (<2%)
Pruritus (<62%) [9] Diaphoresis (<2%) Dehydration (<5%)
Purpura [6] Edema (2–5%) Hyperglycemia (2–5%)
Rash (<5%) [5] Hot flashes (<2%) Hyperkalemia (2–5%)
Red man syndrome [7] Hyperhidrosis (<2%) Hypoglycemia (2–5%)
Serum sickness-like reaction [2] Peripheral edema (15%) [2] Hyponatremia (2–5%)
Stevens-Johnson syndrome [5] Pruritus (9%) Weight gain (2–5%)
Thrombocytopenic purpura [2] Rash (<5%)
Toxic epidermal necrolysis [6] Sunburn (<2%) Genitourinary
Urticaria [8] Dysuria (<2%)
Mucosal Hematuria (<2%)
Vasculitis [5] Epistaxis (nosebleed) (2–5%) Polyuria (<2%)
Cardiovascular Gingival lesions (<2%) Urinary frequency (<2%)
Flushing (7%) [8] Rhinorrhea (<2%)
Xerostomia (2–5%) Renal
Central Nervous System Proteinuria (<2%)
Fever [2] Cardiovascular
Seizures [3] Chest pain (<5%) [2] Hematologic
Vertigo (dizziness) [2] Hypotension (2–5%) Anemia (8%)
Lymphocytosis (<2%)
Neuromuscular/Skeletal Central Nervous System Monocytosis (<2%)
Asthenia (fatigue) [3] Abnormal dreams (<2%) Neutropenia (<2%)
Gastrointestinal/Hepatic Ageusia (taste loss) (<2%)
Amnesia (2–5%) Otic
Abdominal pain [3] Ear pain (<2%)
Diarrhea [2] Anorexia (<5%)
Confusion (2–5%) Tinnitus (<2%)
Hepatitis [3]
Hepatotoxicity [18] Depression (7%) Other
Nausea [4] Dysgeusia (taste perversion) (<2%) [2] Breast cancer [2]
Vomiting [2] Fever (3–6%)
Headache (10%) [8]
Respiratory Hypoesthesia (2–5%)
Pneumonitis [2] Impaired concentration (2–5%)
RILONACEPT
Endocrine/Metabolic Insomnia (<7%) See: www.drugeruptiondata.com/drug/id/1307
Amenorrhea [2] Migraine (<2%)
Porphyria [2] Pain (<5%)
Renal Syncope (<2%)
Nephrotoxicity [10] Tremor (2–5%) RILPIVIRINE
Hematologic See: www.drugeruptiondata.com/drug/id/2507
Agranulocytosis [2] Neuromuscular/Skeletal
Anemia [3] Arthralgia (<6%)
Thrombocytopenia [11] Asthenia (fatigue) (<12%) [3]
Back pain (6%) RILUZOLE
Other Muscle spasm (<9%)
Adverse effects [12] Myalgia/Myopathy (<5%) See: www.drugeruptiondata.com/drug/id/622
Death [7] Neck pain (<2%)
Side effects (5%) Pain in extremities (2–5%)
RIMANTADINE Over 100 updates per week on www.drugeruptiondata.com
Skin
RIMANTADINE Ecchymoses (4%) RISPERIDONE
See: www.drugeruptiondata.com/drug/id/623 Pruritus (3%) Trade names: Risperdal (Ortho-McNeil)
Rash (8%) (Janssen), Risperdal Consta (Ortho-McNeil)
(Janssen)
Cardiovascular
RIMONABANT Chest pain (5%)
Indications: Schizophrenia, bipolar mania,
irritability associated with autistic disorder
Hypertension (11%) Class: Antipsychotic, Mood stabilizer
Central Nervous System Half-life: 330 hours
Depression (7%) Clinically important, potentially hazardous
Fever [2] interactions with: ACE inhibitors, alcohol, alpha
RIOCIGUAT Headache (10%) [3] blockers, amantadine, angiotensin II receptor
Insomnia (5%) antagonists, anxiolytics and hypnotics,
Trade name: Adempas (Bayer) Pain (14%) apomorphine, artemether/lumefantrine,
Indications: Pulmonary hypertension Paresthesias (2%) barbiturates, bromocriptine, cabergoline, calcium
Class: Soluble guanylate cyclase (sGC) stimulator Vertigo (dizziness) (7%) channel blockers, carbamazepine, cimetidine,
Half-life: 7–12 hours citalopram, clozapine, cobicistat/elvitegravir/
Arthralgia (10–24%) [6] emtricitabine/tenofovir alafenamide, cobicistat/
interactions with: antacids, carbamazepine, elvitegravir/emtricitabine/tenofovir disoproxil,
dipyridamole, nitrates or nitric oxide donors, Asthenia (fatigue) (5%)
Back pain (28%) [4] ethosuximide, fluoxetine, general anesthetics,
nitroprusside, phenobarbital, phenytoin, rifampin, histamine, levodopa, memantine, methyldopa,
sildenafil, St John’s wort, tadalafil, theophylline, Bone or joint pain (7%) [5]
Fractures (9%) [9] metoclopramide, opioid analgesics,
vardenafil oxcarbazepine, paliperidone, paroxetine
Pregnancy category: X Myalgia/Myopathy (7%) [3]
Neck pain (5%) [3] hydrochloride, pergolide, phenytoin,
Important contra-indications noted in the pramipexole, primidone, ranitidine, ritonavir,
prescribing guidelines for: nursing mothers; Osteonecrosis [5]
Tendinopathy/Tendon rupture (3%) ropinirole, rotigotine, sodium oxybate,
pediatric patients sympathomimetics, tetrabenazine, tramadol,
Warning: EMBRYO-FETAL TOXICITY Gastrointestinal/Hepatic tricyclics, valproic acid
Abdominal pain (12%) [3] Pregnancy category: C
Skin Constipation (13%) [3] Important contra-indications noted in the
Peripheral edema [2] Diarrhea (11%) [4] prescribing guidelines for: nursing mothers;
Dyspepsia (11%) [2] pediatric patients
Cardiovascular Esophagitis [2]
Hypotension (10%) [6] Note: Safety and effectiveness have not been
Gastrointestinal disorder [3] established for pediatric patients with
Central Nervous System Hepatotoxicity [6] schizophrenia <13 years of age, for bipolar mania
Headache (27%) [3] Nausea (11%) [2] <10 years of age, and for autistic disorder <5
Syncope [2] Respiratory years of age. [C] = in children.
Vertigo (dizziness) (20%) Bronchitis (10%) Warning: INCREASED MORTALITY IN
Gastrointestinal/Hepatic Cough (6%) ELDERLY PATIENTS WITH DEMENTIA-
Constipation (5%) Flu-like syndrome (11%) [2] RELATED PSYCHOSIS
Diarrhea (12%) Influenza [3]
Dyspepsia (21%) [2] Nasopharyngitis [3] Skin
Gastroesophageal reflux (5%) Pharyngitis (6%) Angioedema [6]
Nausea (14%) Rhinitis (6%) Edema [3]
Vomiting (10%) Sinusitis (9%) Peripheral edema (16%) [4]
Hematologic Genitourinary Photosensitivity (<10%) [2]
Anemia (7%) Urinary tract infection (11%) Rash [C] (11%) (2–4%)
Bleeding (2%) [2] Ocular Seborrhea (2%)
Other Cataract (7%) Urticaria [2]
Adverse effects [5] Ocular adverse effects [3] Xerosis (2%)
Scleritis [2] Hair
Other Alopecia [2]
RISEDRONATE Adverse effects [5] Mucosal
Allergic reactions (4%) Sialopenia (5%)
Trade names: Actonel (Procter & Gamble), Infection (31%) [2] Sialorrhea [C] (22%) (<3%) [11]
Atelvia (Warner Chilcott) Tooth disorder (2%) Xerostomia [C] (13%) (4%) [7]
Indications: Paget’s disease of bone, Cardiovascular
osteoporosis Bradycardia [2]
Class: Bisphosphonate Cardiotoxicity [2]
Half-life: terminal: 220 hours Hypotension [2]
Clinically important, potentially hazardous QT prolongation [4]
interactions with: antacids, calcium Tachycardia [C] (7%) (<5%)
supplements, iron preparations, laxatives, Venous thromboembolism [6]
magnesium-based supplements Ventricular arrhythmia [2]
prescribing guidelines for: nursing mothers; Agitation [2]
pediatric patients Akathisia [C] (16%) (5–9%) [18]
Anorexia [C] (8%) (2%)
Litt’s Drug Eruption & Reaction Manual RITONAVIR
Anxiety [C] (16%) (2–16%) [5] Ocular darifenacin, dasatinib, deferasirox, delavirdine,
Catatonia [2] Abnormal vision [C] (4–7%) (<3%) diazepam, diclofenac, dihydroergotamine,
Compulsions [3] Vision blurred [3] docetaxel, dronedarone, dutasteride, efavirenz,
Depression (14%) [7] Local eletriptan, eluxadoline, ergot alkaloids,
Extrapyramidal symptoms [16] Injection-site pain [2] ergotamine, erlotinib, estazolam, estradiol,
Fever [C] (20%) (<2%) eszopiclone, etravirine, everolimus, ezetimibe,
Headache [9] Other fentanyl, fesoterodine, flecainide, flibanserin,
Insomnia [9] Adverse effects [11] flurazepam, fluticasone propionate, glecaprevir &
Neuroleptic malignant syndrome [25] Death [3] pibrentasvir, halazepam, indacaterol,
Neurotoxicity [2] Tooth disorder (<3%) isavuconazonium sulfate, itraconazole, ivabradine,
Parkinsonism [C] (2–16%) (12–20%) [7] ixabepilone, ketoconazole, lapatinib, ledipasvir &
Psychosis [3] sofosbuvir, levomepromazine, levothyroxine,
Rabbit syndrome [3] RITODRINE lomitapide, macitentan, maraviroc, meloxicam,
Restless legs syndrome [2] meperidine, meptazinol, methylergonovine,
Schizophrenia [2] Indications: Preterm labor methysergide, midazolam, midostaurin,
Sedation [4] Class: Beta-2 adrenergic agonist, Tocolytic mifepristone, naldemedine, nelfinavir, neratinib,
Seizures [3] Half-life: 1.312 hours nifedipine, nilotinib, olaparib, oral contraceptives,
Serotonin syndrome [3] Clinically important, potentially hazardous osimertinib, paclitaxel, palbociclib, paroxetine
Somnolence (drowsiness) [C] (12–67%) (5– interactions with: glycopyrrolate hydrochloride, pazopanib, phenytoin, pimozide,
14%) [16] Pregnancy category: B piroxicam, pitavastatin, ponatinib, posaconazole,
Stuttering [2] propafenone, propoxyphene, propranolol,
Suicidal ideation [3] Skin quazepam, quinidine, quinine, ranolazine,
Tardive dyskinesia [5] ribociclib, rifabutin, rifampin, rifapentine,
Anaphylactoid reactions/Anaphylaxis (<3%)
Tremor [C] (10–12%) (6%) [6] rilpivirine, rimonabant, risperidone, rivaroxaban,
Diaphoresis (<14%)
Vertigo (dizziness) [C] (7–16%) (4–10%) [5] romidepsin, rosuvastatin, ruxolitinib, saquinavir,
Erythema (1015%) [2]
Neuromuscular/Skeletal sildenafil, silodosin, simeprevir, simvastatin,
Pustules [2]
Arthralgia (2–3%) sofosbuvir, sofosbuvir/velpatasvir/voxilaprevir,
Rash (<3%)
Asthenia (fatigue) [C] (18–42%) (<3%) [4] solifenacin, St John’s wort, sunitinib, tadalafil,
Back pain (2–3%) telaprevir, telithromycin, temsirolimus, tenofovir
Vasculitis [2]
Dystonia [C] (9–18%) (5–11%) [4] disoproxil, ticagrelor, tolvaptan, trabectedin,
Cardiovascular triazolam, ulipristal, vardenafil, vemurafenib,
Pisa syndrome [3]
Chest pain [2] venetoclax, vorapaxar, voriconazole, zolpidem,
Rhabdomyolysis [7]
Myocardial ischemia [2] zuclopenthixol
Gastrointestinal/Hepatic Pulmonary edema [3] Pregnancy category: B
Abdominal pain [C] (15–18%) (3–4%) Central Nervous System Important contra-indications noted in the
Constipation [C] (21%) (8–9%) [4] prescribing guidelines for: nursing mothers
Chills (310%)
Diarrhea [C] (7%) (73%) Note: Protease inhibitors cause dyslipidemia
Tremor (>10%)
Dyspepsia [C] (5–16%) (4–10%) which includes elevated triglycerides and
Dysphagia [2] Neuromuscular/Skeletal
cholesterol and redistribution of body fat centrally
Nausea [C] (8–16%) (4–9%) [4] Rhabdomyolysis [4]
to produce the so-called ‘protease paunch’,
Pancreatitis [2] Gastrointestinal/Hepatic breast enlargement, facial atrophy, and ‘buffalo
Vomiting [C] (10–25%) Hepatotoxicity [3] hump’. Kaletra is ritonavir and lopinavir. See also
Respiratory Endocrine/Metabolic separate entry for ombitasvir/paritaprevir/
Cough [C] (34%) (3%) Hypokalemia [2] ritonavir.
Dyspnea [C] (2–5%) (2%) Warning: DRUG-DRUG INTERACTIONS
Ocular LEADING TO POTENTIALLY SERIOUS AND/
Pneumonia [2]
Glaucoma [2] OR LIFE THREATENING REACTIONS
Pulmonary embolism [3]
Rhinitis [C] (13–36%) (7–11%) Other
Upper respiratory tract infection [C] (34%) Adverse effects [2] Skin
(2–3%) Acneform eruption (4%)
Endocrine/Metabolic Bullous dermatitis (<2%)
Amenorrhea [6] RITONAVIR Dermatitis (<2%)
Appetite decreased [2] Diaphoresis (<10%)
Appetite increased [C] (49%) [3] Trade names: Kaletra (AbbVie), Norvir (AbbVie) Ecchymoses (<2%)
Diabetes mellitus [2] Indications: HIV infection Eczema (<2%)
Galactorrhea (<10%) [14] Class: Antiretroviral, CYP3A4 inhibitor, HIV-1 Edema (6%)
Gynecomastia (<10%) [6] protease inhibitor Exanthems (<2%) [2]
Hyperprolactinemia [22] Half-life: 35 hours Facial edema (8%)
Metabolic syndrome [5] Clinically important, potentially hazardous Folliculitis (<2%)
Weight gain [C] (5%) [33] interactions with: abiraterone, afatinib, Hypersensitivity (8%)
alfentanil, alfuzosin, alprazolam, amiodarone, Jaundice [3]
Genitourinary
amitriptyline, amprenavir, aprepitant, astemizole, Lipodystrophy [4]
Priapism (<10%) [27]
atazanavir, atorvastatin, atovaquone, atovaquone/ Peripheral edema (6%)
Sexual dysfunction [3]
proguanil, avanafil, azithromycin, bepridil, Photosensitivity (<2%)
Urinary incontinence [C] (5–22%) (2%)
boceprevir, bosentan, brigatinib, buprenorphine, Pruritus (12%)
bupropion, buspirone, cabazitaxel, cabozantinib, Psoriasis (<2%)
Renal calcifediol, carbamazepine, ceritinib, Rash (27%) [12]
Enuresis [4] chlordiazepoxide, ciclesonide, citalopram, Seborrhea (<2%)
Hematologic clozapine, cobicistat/elvitegravir/emtricitabine/ Toxicity [2]
Neutropenia [2] tenofovir disoproxil, colchicine, conivaptan, Urticaria (8%)
copanlisib, crizotinib, cyclosporine, cyproterone,
RITONAVIR See all our books at www.crcpress.com
Xanthomas [2] Ocular Myocardial infarction [2]

Xerosis (<2%) Vision blurred (6%) Central Nervous System
Hair Other Anxiety (5%)
Alopecia [2] Adverse effects [9] Chills (33%) [15]
Mucosal Allergic reactions (<2%) Encephalitis [3]
Cheilitis (<2%) Fever (53%) [23]
Gingivitis (<2%) Headache (19%) [4]
Leukoencephalopathy [27]
Oral candidiasis (<2%) RITUXIMAB Neurotoxicity [3]
Oral ulceration (<2%)
Oropharyngeal pain (16%) Trade names: MabThera (Roche), Rituxan Pain (12%)
Xerostomia (<2%) (Genentech) Peripheral neuropathy [5]
Indications: Non-Hodgkin’s lymphoma, chronic Rigors [4]
Cardiovascular Vertigo (dizziness) (10%)
Cardiotoxicity [2] lymphocytic leukemia, rhematoid arthritis (in
Flushing (13%) combination with methotrexate), granulomatosis Neuromuscular/Skeletal
Hypertension (3%) with polyangiitis and mycroscopic polyangiitis (in Arthralgia (10%) [2]
Hypotension (2%) combination with glucocorticoids) Asthenia (fatigue) (26%) [16]
Orthostatic hypotension (2%) Class: Biologic, CD20-directed cytolytic Back pain (10%)
monoclonal antibody, Disease-modifying Myalgia/Myopathy (10%) [2]
Central Nervous System antirheumatic drug (DMARD),
Ageusia (taste loss) (<2%) Gastrointestinal/Hepatic
Immunosuppressant, Monoclonal antibody Abdominal pain (14%)
Confusion (3%) Half-life: 60 hours (after first infusion)
Dysgeusia (taste perversion) (16%) Colitis [4]
Clinically important, potentially hazardous Constipation [2]
Headache [8] interactions with: benazepril, captopril,
Hyperesthesia (<2%) Diarrhea (10%) [9]
certolizumab, cisplatin, clevidipine, enalapril, Hepatitis [3]
Impaired concentration (3%) fosinopril, irbesartan, lisinopril, olmesartan,
Insomnia [2] Hepatotoxicity [7]
quinapril, ramipril Nausea (23%) [12]
Neurotoxicity [2] Pregnancy category: C
Paresthesias (51%) Pancreatitis [2]
Important contra-indications noted in the Vomiting (10%) [8]
Parosmia (<2%) prescribing guidelines for: nursing mothers;
Peripheral neuropathy (10%) pediatric patients Respiratory
Syncope (3%) Warning: FATAL INFUSION REACTIONS, Acute respiratory distress syndrome [3]
Vertigo (dizziness) (16%) [2] SEVERE MUCOCUTANEOUS REACTIONS, Bronchospasm (8%) [6]
Neuromuscular/Skeletal HEPATITIS B VIRUS REACTIVATION and Cough (increased) (13%) [6]
Arthralgia (19%) PROGRESSIVE MULTIFOCAL Dyspnea (7%) [7]
Asthenia (fatigue) (46%) [3] LEUKOENCEPHALOPATHY Flu-like syndrome [3]
Back pain (19%) Nasopharyngitis [3]
Myalgia/Myopathy (4–9%) Pneumonia [20]
Skin Pneumonitis [2]
Rhabdomyolysis [2] Anaphylactoid reactions/Anaphylaxis [7] Pulmonary toxicity [14]
Gastrointestinal/Hepatic Angioedema (11%) [4] Rhinitis (12%) [2]
Abdominal pain (26%) [2] Dermatitis [2] Sinusitis (6%) [5]
Diarrhea (68%) [14] Diaphoresis (15%) [2] Upper respiratory tract infection [9]
Dyspepsia (12%) Erythema [2]
Flatulence (8%) Herpes simplex [2] Endocrine/Metabolic
Gastrointestinal bleeding (2%) Herpes zoster [7] ALT increased [2]
Gastrointestinal disorder [4] Hypersensitivity [5] AST increased [2]
Hepatotoxicity (9%) [5] Kaposi’s sarcoma [3] Hyperglycemia (9%)
Nausea (57%) [12] Paraneoplastic pemphigus [2] Hyponatremia [2]
Vomiting (32%) [7] Peripheral edema (8%) Genitourinary
Respiratory Pruritus (14%) [8] Urinary tract infection [8]
Cough (22%) Psoriasis [4] Renal
Nasopharyngitis [2] Pyoderma gangrenosum [3] Nephrotoxicity [3]
Upper respiratory tract infection [2] Rash (15%) [12]
Sarcoidosis [2] Hematologic
Endocrine/Metabolic Serum sickness [21] Anemia (8%) [12]
ALT increased [3] Serum sickness-like reaction [5] Cytopenia [3]
Cushing’s syndrome [7] Stevens-Johnson syndrome [5] Febrile neutropenia [15]
Gynecomastia [2] Toxic epidermal necrolysis [3] Hemotoxicity [3]
Hyperbilirubinemia [5] Toxicity [3] Hypogammaglobulinemia [6]
Hypercholesterolemia (3%) [2] Tumor lysis syndrome [3] Leukopenia (14%) [14]
Hyperlipidemia [2] Urticaria (8%) [5] Lymphocytopenia [2]
Hypertriglyceridemia (9%) [2] Vasculitis [4] Lymphopenia (48%) [10]
Genitourinary Myelosuppression [5]
Mucosal Myelotoxicity [2]
Urinary frequency (4%) Mucocutaneous reactions [2] Neutropenia (14%) [49]
Renal Stomatitis [2] Sepsis [3]
Fanconi syndrome [4] Cardiovascular Thrombocytopenia (12%) [37]
Nephrolithiasis [3] Cardiotoxicity [5] Thrombosis [2]
Nephrotoxicity [2] Flushing (5%)
Renal failure [2] Local
Hypertension (6%) [2] Application-site reactions [4]
Hypotension (10%) [10] Infusion-related reactions [22]
Litt’s Drug Eruption & Reaction Manual ROFECOXIB
Infusion-site reactions [11] Rhinitis (4%)

Injection-site pain [2] RIVASTIGMINE Endocrine/Metabolic
Injection-site reactions [4] Dehydration (2%)
Trade name: Exelon (Novartis)
Other Indications: Alzheimer’s disease and dementia Weight loss (3%) [2]
Adverse effects [28] Class: Acetylcholinesterase inhibitor, Genitourinary
Allergic reactions [4] Cholinesterase inhibitor Urinary incontinence (>2%)
Death [26] Half-life: 12 hours Urinary tract infection (7%)
Infection (31%) [51] Clinically important, potentially hazardous Local
interactions with: galantamine Application-site pruritus [2]
Pregnancy category: B Application-site reactions [3]
RIVAROXABAN Important contra-indications noted in the
Other
Trade name: Xarelto (Janssen) pediatric patients Adverse effects [5]
Indications: Prevention of venous Death [2]
thromboembolism in patients undergoing knee or Infection (>2%)
Skin
hip replacement surgery, treatment of deep vein Dermatitis [2]
thrombosis and pulmonary embolism Diaphoresis (10%)
Class: Anticoagulant, Direct factor Xa inhibitor Exanthems [2] RIZATRIPTAN
Half-life: 5–9 hours Hyperhidrosis (4%)
Clinically important, potentially hazardous Peripheral edema (>2%) Trade name: Maxalt (Merck)
interactions with: anticoagulants, aspirin, Rash (>2%) [2] Indications: Migraine
atazanavir, atorvastatin, carbamazepine, Class: 5-HT1 agonist, Serotonin receptor agonist,
clarithromycin, clopidogrel, combined P- Cardiovascular Triptan
glycoprotein and strong CYP3A4 inhibitors and Bradycardia [5] Half-life: 23 hours
inducers, conivaptan, dabigatran, darunavir, Chest pain (>2%) Clinically important, potentially hazardous
delavirdine, diclofenac, efavirenz, enoxaparin, Hypertension (3%) interactions with: dihydroergotamine, ergot-
erythromycin, fosamprenavir, HIV protease QT prolongation [2] containing drugs, isocarboxazid, MAO inhibitors,
inhibitors, indinavir, itraconazole, ketoconazole, Thrombophlebitis (<2%) methysergide, naratriptan, phenelzine,
ketorolac, lapatinib, lopinavir, nelfinavir, Central Nervous System propranolol, sibutramine, SSRIs, St John’s wort,
phenobarbital, phenytoin, posaconazole, rifampin, Aggression (3%) sumatriptan, tranylcypromine, zolmitriptan
ritonavir, saquinavir, St John’s wort, telithromycin, Agitation (>2%) Pregnancy category: C
tipranavir, voriconazole Anorexia (6–17%) [2] Important contra-indications noted in the
Pregnancy category: C Anxiety (4–5%) prescribing guidelines for: nursing mothers
Important contra-indications noted in the Confusion (8%) Note: Safety and effectiveness in pediatric
prescribing guidelines for: nursing mothers; Delusions of parasitosis (>2%) patients <6 years of age have not been
pediatric patients Depression (6%) established.
Note: Contra-indicated in patients with active Hallucinations (4%)
pathological bleeding. Headache (4–17%) Mucosal
Warning: PREMATURE DISCONTINUATION Insomnia (3–9%) Xerostomia (3%)
OF XARELTO INCREASES THE RISK OF Nervousness (>2%)
THROMBOTIC EVENTS Pain (>2%) Cardiovascular
SPINAL/EPIDURAL HEMATOMA Parkinsonism (2%) Chest pain (<3%) [2]
Restlessness [2] Central Nervous System
Skin Somnolence (drowsiness) (3–5%) Headache (<2%)
Hematoma [3] Syncope (3%) [3] Neurotoxicity [2]
Pruritus (2%) Tremor (4–10%) [3] Pain (3%)
Rash [3] Vertigo (dizziness) (6–21%) [4] Paresthesias (3–4%)
Neuromuscular/Skeletal Somnolence (drowsiness) (4–6%)
Mucosal Vertigo (dizziness) (4–9%) [10]
Epistaxis (nosebleed) [6] Arthralgia (>2%)
Gingival bleeding [2] Asthenia (fatigue) (2–9%) Neuromuscular/Skeletal
Back pain (>2%) Asthenia (fatigue) (4–7%) [9]
Gastrointestinal/Hepatic Dystonia [2] Jaw pain (<2%)
Abdominal pain [2] Fractures (>2%) Neck pain (<2%)
Black stools [2] Myalgia/Myopathy (20%)
Gastrointestinal bleeding [3] Gastrointestinal/Hepatic
Pisa syndrome [2] Nausea (4–6%)
Hepatotoxicity [4]
Gastrointestinal/Hepatic Other
Genitourinary Abdominal pain (4–13%)
Hematuria [5] Adverse effects [4]
Hematologic Diarrhea (7–19%) [4]
Anemia (3%) Dyspepsia (9%)
Bleeding [13] Eructation (belching) (2%) ROCURONIUM
Hemorrhage [5] Flatulence (4%)
Nausea (29–47%) [12] See: www.drugeruptiondata.com/drug/id/1187
Other
Vomiting (17–31%) [12]
Adverse effects [4]
Respiratory
Bronchitis (>2%) ROFECOXIB
Cough (>2%)
Flu-like syndrome (3%) See: www.drugeruptiondata.com/drug/id/631
Pharyngitis (>2%)
ROFLUMILAST Over 100 updates per week on www.drugeruptiondata.com
Mucosal
ROFLUMILAST ROLAPITANT Stomatitis (6–10%)
Trade names: Daliresp (Takeda), Daxas (Takeda) Trade name: Varubi (Tesaro) Cardiovascular
Indications: To reduce the risk of COPD Indications: Delayed nausea and vomiting from Hypotension (7–23%)
exacerbations in patients with severe COPD chemotherapy, in combination with Supraventricular arrhythmias (>2%)
associated with chronic bronchitis and a history of dexamethasone and a 5HT3-receptor antagonist Tachycardia (10%)
exacerbations Class: Antiemetic, Neurokinin 1 receptor Ventricular arrhythmia (>2%)
Class: Anti-inflammatory, Phosphodiesterase antagonist Central Nervous System
inhibitor, Phosphodiesterase type 4 (PDE4) Half-life: ~7 days Anorexia (23–54%) [5]
inhibitor Clinically important, potentially hazardous Chills (11–17%)
Half-life: 17 hours interactions with: thioridazine Dysgeusia (taste perversion) (15–40%)
Clinically important, potentially hazardous Pregnancy category: N/A (No data available) Fever (20–47%)
interactions with: aminophylline, Important contra-indications noted in the Headache (15–34%)
carbamazepine, cimetidine, denileukin, efavirenz, prescribing guidelines for: nursing mothers; Neuromuscular/Skeletal
enoxacin, erythromycin, fingolimod, fluvoxamine, pediatric patients Asthenia (fatigue) (53–77%) [10]
ketoconazole, oral contraceptives, pazopanib,
phenobarbital, phenytoin, rifampin Gastrointestinal/Hepatic
Mucosal Abdominal pain (13–14%)
Pregnancy category: C Stomatitis (4%)
Important contra-indications noted in the Constipation (12–40%)
prescribing guidelines for: nursing mothers; Central Nervous System Diarrhea (20–36%)
pediatric patients Headache [5] Nausea (56–86%) [9]
Note: Contra-indicated in patients with Vertigo (dizziness) (6%) Vomiting (34–52%) [5]
moderate to severe liver impairment (Child-Pugh Neuromuscular/Skeletal Respiratory
B or C class). Asthenia (fatigue) [5] Cough (18–21%)
Gastrointestinal/Hepatic Dyspnea (13–21%)
Cardiovascular Abdominal pain (3%) Endocrine/Metabolic
Cardiotoxicity [2] Constipation [6] ALT increased (3–22%)
Hypertension [3] Dyspepsia (4%) [3] AST increased (3–28%)
Central Nervous System Endocrine/Metabolic Hyperglycemia (2–51%)
Anorexia [2] Appetite decreased (9%) Hypermagnesemia (27%)
Anxiety (<2%) [2] Hyperuricemia (33%)
Genitourinary Hypoalbuminemia (3–48%)
Depression (<2%) Urinary tract infection (4%)
Headache (4%) [21] Hypocalcemia (4–52%)
Insomnia (2%) [6] Hematologic Hypokalemia (6–20%)
Neurotoxicity [3] Anemia (3%) Hypomagnesemia (22–28%)
Suicidal ideation [2] Neutropenia (7–9%) [2] Hyponatremia (<20%)
Tremor (<2%) Other Hypophosphatemia (27%)
Vertigo (dizziness) [3] Hiccups (5%) [3] Weight loss (10–15%)
Back pain (3%) [4] Anemia (19–72%) [3]
Muscle spasm (<2%) ROMIDEPSIN Leukopenia (4–55%) [2]
Lymphopenia (4–57%) [2]
Gastrointestinal/Hepatic Neutropenia (11–66%) [5]
Abdominal pain (<2%) [2] Trade name: Istodax (Celgene)
Indications: Cutaneous T-cell lymphoma (CTCL) Sepsis (>2%)
Diarrhea (10%) [25] Thrombocytopenia (17–72%) [8]
Dyspepsia (<2%) Class: Histone deacetylase (HDAC) inhibitor
Gastritis (<2%) Half-life: 3 hours Other
Nausea (5%) [24] Clinically important, potentially hazardous Adverse effects [2]
Vomiting (<2%) [2] interactions with: atazanavir, carbamazepine, Infection (46–54%) [2]
clarithromycin, conivaptan, coumadin derivatives,
Respiratory CYP3A4 inhibitors and inducers, darunavir,
Bronchitis [3]
COPD [3]
delavirdine, dexamethasone, efavirenz, indinavir,
itraconazole, ketoconazole, nefazodone,
ROMIPLOSTIM
Dyspnea [3] nelfinavir, oxcarbazepine, phenobarbital,
Influenza (3%) [3] See: www.drugeruptiondata.com/drug/id/1305
phenytoin, rifabutin, rifampin, rifapentine,
Nasopharyngitis [4] ritonavir, saquinavir, St John’s wort, telithromycin,
Pneumonia [3] voriconazole, warfarin
Rhinitis (<2%) Pregnancy category: D ROPINIROLE
Sinusitis (<2%) Important contra-indications noted in the
Upper respiratory tract infection [4] prescribing guidelines for: nursing mothers; Trade name: Requip (GSK)
Endocrine/Metabolic pediatric patients Indications: Parkinsonism
Appetite decreased (2%) [4] Class: Dopamine receptor agonist
Weight loss (8%) [24] Half-life: ~6 hours
Genitourinary Dermatitis (4–27%) interactions with: ciprofloxacin, estradiol,
Urinary tract infection (<2%) Edema (>2%) levomepromazine, norfloxacin, risperidone,
Other Exfoliative dermatitis (4–27%) warfarin, zuclopenthixol
Adverse effects [6] Peripheral edema (6–10%)
Pruritus (7–31%)
Litt’s Drug Eruption & Reaction Manual ROSUVASTATIN
Important contra-indications noted in the ROPIVACAINE ROSUVASTATIN
pediatric patients See: www.drugeruptiondata.com/drug/id/1771 Trade name: Crestor (AstraZeneca)
Indications: Hypercholesterolemia, mixed
dyslipidemia
Skin
Diaphoresis (3–6%) ROSIGLITAZONE Class: HMG-CoA reductase inhibitor, Statin
Herpes simplex (5%) Clinically important, potentially hazardous
Hyperhidrosis (3%) Trade names: Avandamet (GSK), Avandaryl
(GSK), Avandia (GSK) interactions with: alcohol, amiodarone,
Peripheral edema (2–7%) [2] antacids, atazanavir, ciprofibrate, colchicine,
Rash [2] Indications: Type II diabetes
Class: Antidiabetic, Thiazolidinedione conivaptan, coumarins, cyclosporine, daptomycin,
Mucosal Half-life: 3–4 hours darunavir, dronedarone, elbasvir & grazoprevir,
Xerostomia (5%) Clinically important, potentially hazardous eltrombopag, eluxadoline, erythromycin,
Cardiovascular interactions with: CYP2C8 inhibitors and ethinylestradiol, fenofibrate, fibrates,
Cardiotoxicity [2] inducers, gemfibrozil, grapefruit juice, paclitaxel, fosamprenavir, fusidic acid, gemfibrozil, indinavir,
Chest pain (4%) rifampin, teriflunomide ledipasvir & sofosbuvir, lopinavir, nelfinavir, niacin,
Flushing (3%) Pregnancy category: C niacinamide, phenindione, progestins, protease
Hypotension [2] Important contra-indications noted in the inhibitors, ritonavir, safinamide, saquinavir,
Orthostatic hypotension [4] prescribing guidelines for: nursing mothers sofosbuvir/velpatasvir/voxilaprevir, tipranavir,
Note: Thiazolidinediones, including rosiglitazone, trabectedin, vitamin K antagonists, warfarin
Central Nervous System Pregnancy category: X
Amnesia (3%) cause or exacerbate congestive heart failure in
some patients. Important contra-indications noted in the
Dyskinesia [9] prescribing guidelines for: nursing mothers
Hallucinations (<5%) [7] Contra-indicated in patients with established
Headache (6%) [5] NYHA Class III or IV heart failure. Avandaryl is
Hyperesthesia (4%) rosiglitazone and glimepiride; Avandamet is Skin
Impulse control disorder [3] rosiglitazone and metformin. Peripheral edema (>2%)
Insomnia [2] Warning: CONGESTIVE HEART FAILURE Rash (>2%)
Pain (3–8%) Central Nervous System
Paresthesias (5%) Skin Depression (>2%)
Psychosis [5] Edema (5%) [12] Headache (6%)
Sleep related disorder [2] Peripheral edema [11] Pain (>2%)
Somnolence (drowsiness) (11–40%) [13] Cardiovascular Paresthesias (>2%)
Syncope (<12%) [3] Cardiac failure [13] Vertigo (dizziness) (4%) [3]
Tremor (6%) Congestive heart failure [2] Neuromuscular/Skeletal
Vertigo (dizziness) (6–40%) [16] Myocardial infarction [9] Arthralgia (>2%)
Yawning (3%) Myocardial ischemia [3] Asthenia (fatigue) (3%) [2]
Neuromuscular/Skeletal Central Nervous System Back pain (3%)
Arthralgia (4%) Headache (6%) Myalgia/Myopathy (3%) [18]
Asthenia (fatigue) (8–11%) [4] Stroke [2] Rhabdomyolysis [16]
Back pain [2] Gastrointestinal/Hepatic
Myalgia/Myopathy (3%) Neuromuscular/Skeletal
Arthralgia (5%) Abdominal pain (>2%)
Gastrointestinal/Hepatic Back pain (4%) Constipation (2%)
Abdominal pain (3–7%) [2] Fractures [5] Hepatitis [2]
Constipation [2] Hepatotoxicity [5]
Diarrhea (5%) Gastrointestinal/Hepatic Nausea (3%)
Dyspepsia (4–10%) [3] Hepatotoxicity [9]
Nausea [2] Respiratory
Nausea (40–60%) [18] Cough (>2%)
Vomiting (11%) [3] Respiratory Flu-like syndrome (2%)
Respiratory Dyspnea [2] Rhinitis (2%)
Cough (3%) Nasopharyngitis (6%) Sinusitis (2%)
Dyspnea (3%) Respiratory tract infection (10%)
Endocrine/Metabolic
Flu-like syndrome (3%) Endocrine/Metabolic Creatine phosphokinase increased [2]
Pharyngitis (6–9%) Weight gain [4] Diabetes mellitus [3]
Rhinitis (4%) Genitourinary
Sinusitis (4%) Renal
Bladder disorder [2] Nephrotoxicity [4]
Genitourinary Hematologic Renal failure [3]
Impotence (3%) Anemia [2]
Urinary tract infection (5%) Other
Ocular Adverse effects [8]
Ocular Macular edema [8]
Abnormal vision (6%) Proptosis [2]
Xerophthalmia (2%)
Other
Adverse effects [5] Death [6]
Infection (viral) (11%)
ROTAVIRUS VACCINE See all our books at www.crcpress.com
Tremor (>2%) [2] Pregnancy category: N/A (Can cause fetal

ROTAVIRUS VACCINE Vertigo (dizziness) (3–18%) [7] harm)
Trade names: Rotarix (GSK), RotaTeq (Merck) prescribing guidelines for: nursing mothers;
Indications: Prevention of rotavirus Arthralgia (4%)
Asthenia (fatigue) (8%) [10] pediatric patients
gastroenteritis
Half-life: N/A Back pain (6%)
Clinically important, potentially hazardous Myalgia/Myopathy (2%) Skin
interactions with: none known Gastrointestinal/Hepatic Dermatitis (13%)
Pregnancy category: C Abdominal pain (>2%) Erythema (13%)
Constipation (5%) Exanthems (13%)
Diarrhea (>2%) Hand–foot syndrome (2%)
Central Nervous System Photosensitivity (10%)
Fever [3] Dyspepsia (4%)
Gastrointestinal disorder [2] Pruritus (9%)
Gastrointestinal/Hepatic Nausea (38%) [24] Rash (13%)
Intussusception [2] Vomiting (13%) [6] Central Nervous System
Respiratory Dysgeusia (taste perversion) (39%) [2]
Cough (>2%) Fever (11%)
ROTIGOTINE Flu-like syndrome (>2%) Vertigo (dizziness) (17%)
Rhinitis (>2%) Neuromuscular/Skeletal
Trade name: Neupro (Schwarz) Sinusitis (3%) Asthenia (fatigue) (77%) [4]
Indications: Parkinsonism, restless legs Upper respiratory tract infection (>2%)
syndrome Gastrointestinal/Hepatic
Class: Dopamine receptor agonist Genitourinary Abdominal pain (32%) [2]
Half-life: 5–7 hours Urinary frequency (>2%) Constipation (40%) [2]
Clinically important, potentially hazardous Urinary tract infection (3%) Diarrhea (34%) [2]
interactions with: antipsychotics, Ocular Nausea (77%) [4]
levomepromazine, memantine, methyldopa, Abnormal vision (3%) Vomiting (46%) [4]
metoclopramide, risperidone, zuclopenthixol Hallucinations, visual (2%) [2] Respiratory
Pregnancy category: C Visual disturbances (3%) Dyspnea (21%)
Important contra-indications noted in the Local Endocrine/Metabolic
prescribing guidelines for: nursing mothers; Application-site erythema [4] ALT increased (74%) [3]
pediatric patients Application-site pruritus [4] Appetite decreased (39%)
Note: Neupro contains sodium metabisulfite Application-site reactions (37%) [31] AST increased (73%) [4]
which is capable of causing anaphylactoid Hypercholesterolemia (40%)
reactions in patients with sulfite allergy. Other
Adverse effects [6] Serum creatinine increased (92%)
Hematologic
Skin Anemia (44%) [6]
Diaphoresis (4%)
Erythema (2%) ROXATIDINE Lymphocytopenia (45%)
Neutropenia (15%) [2]
Peripheral edema (7%) [3] Thrombocytopenia (21%) [2]
Rash (2%) [3] See: www.drugeruptiondata.com/drug/id/1080
Mucosal
Xerostomia (3%) [3]
ROXITHROMYCIN RUFINAMIDE
Cardiovascular
Chest pain (>2%) See: www.drugeruptiondata.com/drug/id/1117 See: www.drugeruptiondata.com/drug/id/1320
Hypertension (3%)
Hypotension [2]
Central Nervous System RUCAPARIB * RUPATADINE
Abnormal dreams (3%)
Anorexia (3%) Trade name: Rubraca (Clovis) See: www.drugeruptiondata.com/drug/id/1387
Anxiety (>2%) Indications: Advanced BRCA-mutated ovarian
Depression (>2%) cancer
Dyskinesia [4]
Gait instability [2]
Class: Poly (ADP-ribose) polymerase (PARP) RUXOLITINIB
inhibitor
Hallucinations (2%) [3] Half-life: 17 hours See: www.drugeruptiondata.com/drug/id/2717
Headache (14%) [8] Clinically important, potentially hazardous
Impulse control disorder [4] interactions with: none known
Insomnia (10%) [3]
Somnolence (drowsiness) (25%) [16]
Litt’s Drug Eruption & Reaction Manual SAQUINAVIR
Renal
SACCHARIN Nephrotoxicity [3] SALMETEROL
Renal failure (5%)
Indications: Sugar substitute See: www.drugeruptiondata.com/drug/id/635
Class: Sweetening agent Other
Half-life: N/A Adverse effects [2]
SALSALATE
Pregnancy category: N/A SAFINAMIDE * Trade name: Mono-Gesic (Schwarz)
Note: Saccharin is a sulfonamide and can be Indications: Arthritis
absorbed systemically. Sulfonamides can produce Trade name: Xadago (Newron) Class: Non-steroidal anti-inflammatory (NSAID),
severe, possibly fatal, reactions such as toxic Indications: Adjunctive treatment to levodopa/ Salicylate
epidermal necrolysis and Stevens-Johnson carbidopa in patients with Parkinson’s disease Half-life: 78 hours
syndrome. experiencing ’off’ episodes Clinically important, potentially hazardous
Class: Monoamine oxidase B inhibitor interactions with: dichlorphenamide,
Skin Half-life: 20–26 hours methotrexate
Dermatitis [3] Clinically important, potentially hazardous Pregnancy category: C
Exanthems [2] interactions with: cyclobenzaprine, Important contra-indications noted in the
Photosensitivity [3] dextromethorphan, dopaminergic antagonists, prescribing guidelines for: nursing mothers;
Pruritus [3] imatinib, irinotecan, isoniazid, lapatinib, linezolid, pediatric patients
Urticaria [5] meperidine, methadone, methylphenidate, Note: NSAIDs may cause an increased risk of
metoclopramide, mitoxantrone, other MAO serious cardiovascular and gastrointestinal
inhibitors, propoxyphene, rosuvastatin, adverse events, which can be fatal. This risk may
serotonergic drugs, St John’s wort, sulfasalazine,
SACUBITRIL/ sympathomimetics, topotecan, tramadol, tricyclic
or tetracyclic antidepressants
VALSARTAN Pregnancy category: C Skin
Important contra-indications noted in the Anaphylactoid reactions/Anaphylaxis
Trade name: Entresto (Novartis) (<10%)
Indications: To reduce risk of cardiovascular Rash (<10%)
pediatric patients
death and hospitalization for heart failure in
chronic heart failure
Class: Angiotensin receptor neprilysin inhibitor Skin
(ARNI) Peripheral edema [2] SAPROPTERIN
Half-life: <12 hours Cardiovascular See: www.drugeruptiondata.com/drug/id/1271
Clinically important, potentially hazardous Hypertension [3]
interactions with: ACE inhibitors, aliskiren, Orthostatic hypotension (2%)
lithium, NSAIDs, potassium-sparing diuretics
Pregnancy category: N/A (Can cause fetal Central Nervous System
Anxiety (2%)
SAQUINAVIR
harm)
Important contra-indications noted in the Dyskinesia (17–21%) [5] Trade name: Invirase (Roche)
prescribing guidelines for: nursing mothers; Fever [3] Indications: Advanced HIV infection
pediatric patients Gait instability (4–6%) [2] Class: Antiretroviral, CYP3A4 inhibitor, HIV-1
Note: Contra-indicated in patients with a history Headache [3] protease inhibitor
of angioedema related to previous therapy with Insomnia (<4%) [2] Half-life: 12 hours
angiotensin-converting enzyme inhibitor or Parkinsonism (exacerbation) [2] Clinically important, potentially hazardous
angiotensin II receptor blocker. See also separate Tremor [2] interactions with: abiraterone, afatinib,
profile for valsartan. Vertigo (dizziness) [2] alprazolam, amitriptyline, amprenavir, astemizole,
Warning: FETAL TOXICITY Neuromuscular/Skeletal atazanavir, atorvastatin, avanafil, brigatinib,
Asthenia (fatigue) [2] cabazitaxel, cabozantinib, calcifediol, clindamycin,
Back pain [3] clozapine, copanlisib, crizotinib, darifenacin,
Skin
Gastrointestinal/Hepatic darunavir, dasatinib, delavirdine,
Angioedema (<2%) [2]
Abdominal pain [2] dihydroergotamine, dronedarone, efavirenz,
Constipation [2] elbasvir & grazoprevir, eluxadoline, eplerenone,
Cardiovascular ergot derivatives, everolimus, fentanyl,
Hypotension (18%) [4] Dyspepsia (<2%)
Nausea (3–6%) [2] fesoterodine, flibanserin, fluticasone propionate,
Orthostatic hypotension (2%) itraconazole, ixabepilone, ketoconazole, lapatinib,
Vomiting [2]
Central Nervous System levomepromazine, lomitapide, lopinavir,
Gait instability (2%) Respiratory maraviroc, methysergide, midazolam,
Vertigo (dizziness) (6%) [2] Cough (2%) [2] midostaurin, mifepristone, naldemedine,
Nasopharyngitis [2] nelfinavir, neratinib, olaparib, omeprazole,
Endocrine/Metabolic paclitaxel, palbociclib, pantoprazole, pazopanib,
Arthralgia [2]
ALT increased (3–7%) pentamidine, phenytoin, pimozide, ponatinib,
Gastrointestinal/Hepatic AST increased (6–7%) quinine, ribociclib, rifampin, rilpivirine, ritonavir,
Constipation [2] Weight loss [2] rivaroxaban, romidepsin, rosuvastatin, ruxolitinib,
Respiratory sildenafil, simeprevir, simvastatin, solifenacin,
Ocular
Cough (9%) [4] sonidegib, St John’s wort, sunitinib, tadalafil,
Cataract [3]
Nasopharyngitis [2] telithromycin, temsirolimus, ticagrelor, tipranavir,
Vision blurred [2]
tolvaptan, vardenafil, vemurafenib, vorapaxar,
Endocrine/Metabolic voriconazole
Hyperkalemia (12%) [4]
SAQUINAVIR Over 100 updates per week on www.drugeruptiondata.com
Pregnancy category: B Upper respiratory tract infection (3–4%) Other

Important contra-indications noted in the Endocrine/Metabolic Adverse effects [7]
prescribing guidelines for: nursing mothers ALT increased (5%) [3] Infection [2]
Note: Protease inhibitors cause dyslipidemia AST increased (38–43%)
which includes elevated triglycerides and Hypertriglyceridemia (<3%)
cholesterol and redistribution of body fat centrally
to produce the so-called ‘protease paunch’, Genitourinary SCOPOLAMINE
breast enlargement, facial atrophy, and ‘buffalo Urinary tract infection (3%)
hump’. Hematologic
Leukopenia (<2%)
Skin Neutropenia (7–10%) [5]
Acneform eruption (<2%) Local
SEBELIPASE ALFA
Candidiasis (<2%) Injection-site erythema (4–5%) Trade name: Kanuma (Alexion)
Dermatitis (<2%) Injection-site pruritus (2%) Indications: Lysosomal acid lipase deficiency
Diaphoresis (<2%) Injection-site reactions (6–7%) Class: Enzyme replacement
Eczema (<2%) Other Half-life: 5–7 minutes
Erythema (<2%) Infection [5] Clinically important, potentially hazardous
Exanthems (<2%) interactions with: none known
Folliculitis (<2%) Pregnancy category: N/A (No available data)
Herpes simplex (<2%)
Herpes zoster (<2%) SAXAGLIPTIN Important contra-indications noted in the
Photosensitivity (<2%)
Pigmentation (<2%) Trade names: Onglyza (Bristol-Myers Squibb),
Seborrheic dermatitis (<2%) Qtern (AstraZeneca) Skin
Ulcerations (<2%) Indications: Type II diabetes mellitus Hypersensitivity (20%)
Urticaria (<2%) Class: Antidiabetic, Dipeptidyl peptidase-4 (DPP- Urticaria (33%)
Verrucae (<2%) 4) inhibitor Mucosal
Xerosis (<2%) Half-life: 2.5–3.1 hours Oropharyngeal pain (17%)
Hair interactions with: ACE inhibitors, alcohol, Cardiovascular
Hair changes (<2%) aprepitant, beta blockers, bexarotene, colchicine, Chest pain (<8%)
Mucosal conivaptan, corticosteroids, CYP3A4 inducers, Tachycardia (<30%)
Cheilitis (<2%) darunavir, dasatinib, delavirdine, diazoxide, Central Nervous System
Gingivitis (<2%) diuretics, efavirenz, estradiol, estrogens, Anxiety (<8%)
Glossitis (<2%) hypoglycemic agents, indinavir, ketoconazole, Fever (25–56%)
Oral ulceration (2%) lapatinib, MAO inhibitors, oxcarbazepine, P- Headache (28%)
Stomatitis (<2%) glycoprotein inhibitors and inducers, Neuromuscular/Skeletal
Xerostomia (<2%) pegvisomant, pioglitazone, rifapentine, Asthenia (fatigue) (8%)
Cardiovascular somatropin, strong CYP3A4/5 inhibitors, Hypotonia (<30%)
QT prolongation [3] telithromycin, terbinafine, testosterone,
voriconazole Gastrointestinal/Hepatic
Central Nervous System Pregnancy category: B Constipation (8%)
Dysesthesia (<2%) Important contra-indications noted in the Diarrhea (67%)
Dysgeusia (taste perversion) (<2%) prescribing guidelines for: nursing mothers; Nausea (8%)
Hyperesthesia (<2%) pediatric patients Vomiting (67%)
Paresthesias (3%) Note: Qtern is saxagliptin and dapagliflozin. Respiratory
Gastrointestinal/Hepatic Cough (33%)
Hepatotoxicity [2] Skin Nasopharyngitis (11–33%)
Endocrine/Metabolic Hypersensitivity (<2%) Rhinitis (56%)
Gynecomastia [2] Peripheral edema (2–3%) Hematologic
Cardiovascular Anemia (44%)
Cardiac disorder [2] Other
SARILUMAB * Cardiac failure [2] Sneezing (<30%)
Trade name: Kevzara (Sanofi) Headache (7%) [7]
Indications: Rheumatoid arthritis
Class: Anti-interleukin-6 receptor monoclonal Gastrointestinal/Hepatic SECNIDAZOLE *
antibody, Monoclonal antibody Abdominal pain (2%)
Diarrhea [5] Trade name: Solosec (Symbiomix)
Half-life: 8–10 days (concentration-dependent)
Gastroenteritis (2%) Indications: Bacterial vaginosis
Vomiting (2%) Class: Antibiotic, nitroimidazole
Pregnancy category: N/A (Based on animal Respiratory Clinically important, potentially hazardous
data, may cause fetal harm) Nasopharyngitis [4] interactions with: none known
Important contra-indications noted in the Sinusitis (3%) [2] Pregnancy category: N/A (Insufficient evidence
prescribing guidelines for: the elderly; nursing Upper respiratory tract infection (8%) [8] to inform drug-associated risk)
mothers; pediatric patients Endocrine/Metabolic Important contra-indications noted in the
Warning: RISK OF SERIOUS INFECTIONS Hypoglycemia [9] prescribing guidelines for: nursing mothers;
Genitourinary pediatric patients
Respiratory Urinary tract infection (7%) [7] Note: Potential risk for carcinogenicity from
Nasopharyngitis (>3%) animal studies – avoid chronic use.
Litt’s Drug Eruption & Reaction Manual SERTRALINE
SELEGILINE Arthralgia (11%)
Headache (4%) [3] Jaw pain (26%) [5]
Synonyms: deprenyl; L-deprenyl Myalgia/Myopathy (16%)
Gastrointestinal/Hepatic Trade names: Eldepryl (Somerset), Emsam Pain in extremities (17%)
Abdominal pain (2%) (Mylan Specialty), Zelapar (Valeant)
Diarrhea (3%) Indications: Parkinsonism Gastrointestinal/Hepatic
Nausea [3] Class: Antidepressant, Monoamine oxidase B Diarrhea (42%) [3]
inhibitor Nausea (33%) [5]
Genitourinary Vomiting (18%)
Vulvovaginal candidiasis (10%)
Vulvovaginal pruritus (2%)
Clinically important, potentially hazardous Endocrine/Metabolic
interactions with: amitriptyline, carbidopa, Appetite decreased (6%)
citalopram, doxepin, ephedra, ephedrine, Hematologic
escitalopram, fluoxetine, fluvoxamine, levodopa, Anemia (8%)
SECOBARBITAL meperidine, methadone, moclobemide,
naratriptan, nefazodone, oral contraceptives,
See: www.drugeruptiondata.com/drug/id/640 oxcarbazepine, paroxetine hydrochloride,
propoxyphene, sertraline, tramadol, valbenazine, SERMORELIN
venlafaxine
SECRETIN Pregnancy category: C
See: www.drugeruptiondata.com/drug/id/641 prescribing guidelines for: nursing mothers;
pediatric patients SERTACONAZOLE
Warning: SUICIDALITY IN CHILDREN AND
ADOLESCENTS See: www.drugeruptiondata.com/drug/id/1023
SECUKINUMAB
Trade name: Cosentyx (Novartis) Mucosal
Indications: Plaque psoriasis, psoriatic arthritis, Xerostomia (>10%) [2] SERTINDOLE
ankylosing spondylitis Cardiovascular
Class: Interleukin-17A (IL-17A) antagonist, Hypertension [2] See: www.drugeruptiondata.com/drug/id/2455
Monoclonal antibody
Hallucinations [2]
Headache [2] SERTRALINE
Trade name: Zoloft (Pfizer)
Important contra-indications noted in the Gastrointestinal/Hepatic Indications: Depression, panic disorders,
prescribing guidelines for: nursing mothers; Nausea [2] obsessive compulsive disorders
pediatric patients Local Class: Antidepressant, Selective serotonin
Note: Use with caution in patients with Application-site reactions [5] reuptake inhibitor (SSRI)
inflammatory bowel disease. Half-life: 2426 hours
Other
Bruxism (<10%) Clinically important, potentially hazardous
Skin interactions with: amphetamines, astemizole,
Candidiasis [4] clarithromycin, clozapine, darunavir,
Neoplasms [2] dextroamphetamine, diethylpropion, droperidol,
Pruritus [3] SELENIUM efavirenz, erythromycin, isocarboxazid, linezolid,
Psoriasis (exacerbation) [2] MAO inhibitors, mazindol, methamphetamine,
See: www.drugeruptiondata.com/drug/id/915 metoclopramide, phendimetrazine, phenelzine,
Cardiovascular
phentermine, phenylpropanolamine, pimozide,
Hypertension [2]
pseudoephedrine, selegiline, sibutramine, St
Headache [13]
SELEXIPAG John’s wort, sumatriptan, sympathomimetics,
tranylcypromine, trazodone, troleandomycin,
Neuromuscular/Skeletal Trade name: Uptravi (Actelion) zolmitriptan
Arthralgia [3] Indications: Pulmonary arterial hypertension Pregnancy category: C
Class: Prostacyclin receptor agonist
Half-life: <3 hours Skin
Clinically important, potentially hazardous Angioedema [3]
Respiratory interactions with: gemfibrozil, strong CYP2C8 Diaphoresis (8%) [6]
Nasopharyngitis (11–12%) [19] inhibitors Rash (<10%)
Upper respiratory tract infection (3%) [12] Pregnancy category: N/A (No data available) Stevens-Johnson syndrome [2]
Hematologic Important contra-indications noted in the
prescribing guidelines for: nursing mothers Hair
Neutropenia [4]
Alopecia [3]
Local
Skin Mucosal
Rash (11%) Xerostomia (16%) [7]
Other
Cardiovascular Cardiovascular
Adverse effects [5]
Flushing (12%) Chest pain (<10%)
Infection (29%) [12]
Flushing (2%)
Central Nervous System Palpitation (<10%)
Headache (65%) [7] QT prolongation [3]
SERTRALINE See all our books at www.crcpress.com
Central Nervous System Palpitation (<2%)

Akathisia [6] SILDENAFIL Postural hypotension (<2%)
Anxiety (<10%) Tachycardia (<2%)
Coma [2] Trade names: Revatio (Pfizer), Viagra (Pfizer) Vasodilation [3]
Headache (>10%) Indications: Erectile dysfunction, hypertension Ventricular arrhythmia [2]
Hypoesthesia (5%) Class: Phosphodiesterase type 5 (PDE5) inhibitor
Insomnia (>10%) Abnormal dreams (<2%)
Mania [4] Clinically important, potentially hazardous
interactions with: alfuzosin, alpha blockers, Amnesia [3]
Pain (<10%) Anorgasmia (<2%)
Paresthesias (<10%) amlodipine, amprenavir, amyl nitrite, antifungals,
antihypertensives, atazanavir, boceprevir, Chills (<2%)
Restless legs syndrome [3] Depression (<2%)
Seizures [2] bosentan, cimetidine, clarithromycin, cobicistat/
elvitegravir/emtricitabine/tenofovir alafenamide, Fever (6%)
Serotonin syndrome [10] Headache (16–46%) [40]
Somnolence (drowsiness) (>10%) cobicistat/elvitegravir/emtricitabine/tenofovir
disoproxil, conivaptan, CYP3A4 inhibitors and Hyperesthesia (<2%)
Tremor (<10%) [3] Insomnia (7%)
Vertigo (dizziness) (>10%) [3] inducers, darunavir, dasabuvir/ombitasvir/
paritaprevir/ritonavir, dasatinib, deferasirox, Migraine (<2%)
Yawning (<10%) Neurotoxicity (<2%)
delavirdine, disopyramide, erythromycin,
Neuromuscular/Skeletal etravirine, fosamprenavir, grapefruit juice, high-fat Pain (<2%)
Asthenia (fatigue) (>10%) foods, HMG-CoA reductase inhibitors, indinavir, Paresthesias (3%)
Back pain (<10%) isosorbide, isosorbide dinitrate, isosorbide Seizures [3]
Gastrointestinal/Hepatic mononitrate, itraconazole, ketoconazole, Somnolence (drowsiness) (<2%)
Constipation (<10%) lopinavir, macrolide antibiotics, nelfinavir, Stroke [2]
Diarrhea (>10%) [3] nicorandil, nitrates, nitroglycerin, ombitasvir/ Subarachnoid hemorrhage [2]
Hepatotoxicity [4] paritaprevir/ritonavir, other phosphodiesterase 5 Syncope (<2%)
Nausea (10%) [2] inhibitors, paclitaxel, PEG-interferon, riociguat, Tremor (<2%)
Vomiting (>10%) ritonavir, sapropterin, saquinavir, St John’s wort, Vertigo (dizziness) (2%) [7]
Respiratory telaprevir, telithromycin, tipranavir Neuromuscular/Skeletal
Rhinitis (<10%) Pregnancy category: B Arthralgia (<2%)
Important contra-indications noted in the Asthenia (fatigue) (<2%) [2]
Endocrine/Metabolic prescribing guidelines for: nursing mothers; Ataxia (<2%)
Galactorrhea [4] pediatric patients Back pain [3]
Gynecomastia [2] Bone or joint pain (<2%)
Hyponatremia [4] Gouty tophi (<2%)
Libido decreased (>10%) Skin
Dermatitis (<2%) Hypertonia (<2%)
SIADH [14] Myalgia/Myopathy (7%) [4]
Weight gain (<10%) Diaphoresis (<2%)
Edema (<2%) Tendinopathy/Tendon rupture (<2%)
Genitourinary Erythema (6%) Gastrointestinal/Hepatic
Impotence (<10%) Exfoliative dermatitis (<2%) Abdominal pain (<2%) [3]
Priapism [5] Facial edema (<2%) Colitis (<2%)
Sexual dysfunction (10%) [4] Genital edema (<2%) Diarrhea (3–9%) [4]
Otic Herpes simplex (<2%) Dyspepsia (7–17%) [15]
Tinnitus (<10%) Lichenoid eruption [2] Dysphagia (<2%)
Peripheral edema (<2%) Esophagitis (<2%)
Ocular
Photosensitivity (<2%) Gastritis (<2%)
Abnormal vision (<10%)
Pruritus (<2%) Gastroenteritis (<2%)
Hallucinations, visual [3]
Rash (2%) Hepatotoxicity [2]
Other Ulcerations (<2%) Nausea [4]
Adverse effects [4] Urticaria (<2%) Vomiting (<2%)
Mucosal Respiratory
Bruxism [3]
Epistaxis (nosebleed) (9–13%) [2] Asthma (<2%)
Death [5]
Gingivitis (<2%) Bronchitis (<2%)
Glossitis (<2%) Cough (<2%)
Nasal congestion [7] Dyspnea (7%) [4]
SEVELAMER Rectal hemorrhage (<2%) Hemoptysis [2]
Stomatitis (<2%) Hypoxia [3]
See: www.drugeruptiondata.com/drug/id/1402 Xerostomia (<2%) Laryngitis (<2%)
Cardiovascular Pharyngitis (<2%)
Angina (<2%) Pneumonia [2]
SEVOFLURANE Atrial fibrillation [2] Respiratory failure [3]
Atrioventricular block (<2%) Rhinitis (4%) [6]
See: www.drugeruptiondata.com/drug/id/1197 Cardiac arrest (<2%) [2] Sinusitis (<2%)
Cardiac failure (<2%) Stridor [2]
Cardiomyopathy (<2%) Upper respiratory tract infection [2]
SIBUTRAMINE Chest pain (<2%) [2] Endocrine/Metabolic
Congestive heart failure [2] Gynecomastia (<2%)
See: www.drugeruptiondata.com/drug/id/644 Flushing (1025%) [34] Hyperglycemia (<2%)
Hypotension (<2%) [5] Hypernatremia (<2%)
Myocardial infarction [4] Hyperuricemia (<2%)
Myocardial ischemia (<2%)
Litt’s Drug Eruption & Reaction Manual SIMVASTATIN
Genitourinary Vertigo (dizziness) (3%) [8] Vomiting [2]

Cystitis (<2%) Neuromuscular/Skeletal Respiratory
Ejaculatory dysfunction (<2%) Asthenia (fatigue) (<2%) Dyspnea (12%)
Nocturia (<2%) Flu-like syndrome [3]
Priapism [6] Gastrointestinal/Hepatic
Urinary frequency (<2%) Abdominal pain (<2%) Endocrine/Metabolic
Urinary incontinence (<2%) Diarrhea (3%) [2] Hyperbilirubinemia [9]
Urinary tract infection (3%) Respiratory Hematologic
Hematologic Nasopharyngitis (2%) Anemia [11]
Anemia (<2%) Sinusitis (<2%) Neutropenia [3]
Leukopenia (<2%) Genitourinary Other
Otic Ejaculatory dysfunction (25%) [28] Adverse effects [7]
Ear pain (<2%) Retrograde ejaculation (28%) [4]
Hearing loss (<2%) [4] Other
Tinnitus (<2%) [2] Adverse effects [2] SIMVASTATIN
Ocular Dipsia (thirst) (7%) [2]
Abnormal vision [3] Trade names: Inegy (MSD), Simcor (AbbVie),
Cataract (<2%) Vytorin (MSD), Zocor (Merck)
Conjunctivitis (<2%) SILTUXIMAB Indications: Hypercholesterolemia
Class: HMG-CoA reductase inhibitor, Statin
Dyschromatopsia (blue-green vision) (311%)
[5] See: www.drugeruptiondata.com/drug/id/3515 Half-life: 1.9 hours
Mydriasis (<2%) Clinically important, potentially hazardous
Ocular hemorrhage (<2%) interactions with: alitretinoin, amiodarone,
amlodipine, amprenavir, atazanavir, azithromycin,
Ocular pain (<2%)
Ocular pigmentation (<2%)
SIMEPREVIR boceprevir, bosentan, carbamazepine,
Optic neuropathy [18] ciprofibrate, clarithromycin, clopidogrel,
Trade name: Olysio (Janssen) colchicine, conivaptan, coumarins, cyclosporine,
Photophobia (<2%) Indications: Hepatitis C
Retinal vein occlusion [2] danazol, darunavir, dasabuvir/ombitasvir/
Class: Direct-acting antiviral, Hepatitis C virus paritaprevir/ritonavir, dasatinib, delavirdine,
Vision blurred [4] NS3/4A protease inhibitor
Visual disturbances [5] diltiazem, dronedarone, efavirenz, elbasvir &
Half-life: 10–13 hours grazoprevir, erythromycin, fosamprenavir, fusidic
Xerophthalmia (<2%) Clinically important, potentially hazardous acid, gemfibrozil, glecaprevir & pibrentasvir,
Other interactions with: atazanavir, carbamazepine, grapefruit juice, HIV protease inhibitors, imatinib,
Adverse effects [5] cisapride, clarithromycin, cobicistat/elvitegravir/ imidazoles, indinavir, itraconazole, ketoconazole,
Allergic reactions (<2%) emtricitabine/tenofovir disoproxil, darunavir, lomitapide, lopinavir, miconazole, mifepristone,
Death [3] delavirdine, dexamethasone, efavirenz, nefazodone, nelfinavir, ombitasvir/paritaprevir/
Dipsia (thirst) (<2%) erythromycin, etravirine, fluconazole, ritonavir, paclitaxel, pazopanib, posaconazole,
fosamprenavir, indinavir, itraconazole, rabeprazole, ranolazine, red rice yeast, rifampin,
ketoconazole, ledipasvir & sofosbuvir, lopinavir, ritonavir, roxithromycin, saquinavir, selenium, St
SILODOSIN milk thistle, nelfinavir, nevirapine, oxcarbazepine,
phenobarbital, phenytoin, posaconazole, rifabutin,
John’s wort, tacrolimus, telaprevir, telithromycin,
ticagrelor, tipranavir, triazoles, verapamil,
Trade names: Rapaflo (Watson), Urief (Kissei) rifampin, rifapentine, ritonavir, saquinavir, St voriconazole, warfarin
Indications: Benign prostatic hyperplasia John’s wort, telithromycin, tipranavir, Pregnancy category: X
Class: Adrenergic alpha-receptor antagonist voriconazole Important contra-indications noted in the
Half-life: 4.76 hours Pregnancy category: X (simeprevir is prescribing guidelines for: nursing mothers;
Clinically important, potentially hazardous pregnancy category C but must not be used in pediatric patients
interactions with: alpha blockers, monotherapy) Note: Simcor is simvastatin and niacin; Vytorin is
antihypertensives, atorvastatin, clarithromycin, Important contra-indications noted in the simvastatin and ezetimibe.
conivaptan, cyclosporine, darunavir, delavirdine, prescribing guidelines for: nursing mothers;
diltiazem, erythromycin, indinavir, itraconazole, pediatric patients
Note: Must be used in combination with PEG- Skin
ketoconazole, lapatinib, ritonavir, stong CYP3A4 Dermatomyositis [5]
inhibitors, telithromycin, vasodilators, verapamil, interferon and ribavirin (see separate entries).
Warning: RISK OF HEPATITIS B VIRUS Eczema (5%) [4]
voriconazole Edema (3%)
Pregnancy category: B (Not indicated for use in REACTIVATION IN PATIENTS COINFECTED
WITH HCV AND HBV Eosinophilic fasciitis [2]
women) Erythema multiforme [2]
Important contra-indications noted in the Lichen planus pemphigoides [2]
prescribing guidelines for: pediatric patients Skin Lupus erythematosus [5]
Note: Contra-indicated in patients with severe Photosensitivity (28%) [5] Peripheral edema [2]
hepatic or renal impairment. Pruritus (22%) [8] Photosensitivity [7]
Rash (28%) [10] Pruritus [3]
Mucosal Central Nervous System Purpura [3]
Nasal congestion (2%) [3] Fever [2] Rash (<10%) [4]
Rhinorrhea (<2%) Headache [13] Vasculitis [2]
Cardiovascular Insomnia [3] Mucosal
Orthostatic hypotension (3%) [9] Neuromuscular/Skeletal Stomatitis [2]
Postural hypotension [2] Asthenia (fatigue) [10] Cardiovascular
Central Nervous System Myalgia/Myopathy (16%) Atrial fibrillation (6%)
Headache (2%) [3] Gastrointestinal/Hepatic Central Nervous System
Insomnia (<2%) Nausea (22%) [9] Cognitive impairment [3]
SIMVASTATIN Over 100 updates per week on www.drugeruptiondata.com
Headache (3–7%) ramipril, ribociclib, St John’s wort, tacrolimus, Endocrine/Metabolic

Memory loss [2] telaprevir, telithromycin, tipranavir, venetoclax, Hypercholesterolemia [2]
Vertigo (dizziness) (5%) voriconazole, zotarolimus Hyperlipidemia [2]
Neuromuscular/Skeletal Pregnancy category: C Hypertriglyceridemia [2]
Asthenia (fatigue) (9%) [3] Important contra-indications noted in the Renal
Compartment syndrome [2] prescribing guidelines for: the elderly; nursing Nephrotoxicity [2]
Myalgia/Myopathy (<10%) [37] mothers; pediatric patients Proteinuria [5]
Rhabdomyolysis [87] Warning: IMMUNOSUPPRESSION, USE IS
NOT RECOMMENDED IN LIVER OR LUNG Hematologic
Tendinopathy/Tendon rupture [3] Anemia [3]
TRANSPLANT PATIENTS
Gastrointestinal/Hepatic Dyslipidemia [4]
Abdominal pain (7%) Hemolytic uremic syndrome [2]
Constipation (2–7%) Skin Leukopenia [2]
Diarrhea [5] Abscess (320%) Neutropenia [2]
Gastritis (5%) Acneform eruption (2031%) [9] Thrombosis [2]
Hepatitis [4] Angioedema [5]
Cellulitis (320%) Otic
Hepatotoxicity [7] Tinnitus (320%)
Nausea (5%) Dermatitis [3]
Pancreatitis [7] Diaphoresis (320%) Ocular
Ecchymoses (320%) Eyelid edema (40%) [2]
Respiratory Edema (1624%) [6]
Bronchitis (7%) Local
Facial edema (320%) [2]
Upper respiratory tract infection (9%) Application-site pruritus [2]
Folliculitis [3]
Endocrine/Metabolic Fungal dermatitis (320%) Other
Creatine phosphokinase increased [2] Hypertrophy (320%) Adverse effects [5]
Diabetes mellitus [4] Lymphedema [2] Death [3]
Peripheral edema (5464%) [3] Infection [5]
Renal
Nephrotoxicity [2] Pruritus (320%)
Renal failure [9] Purpura (320%)
Hematologic
Rash (1020%) [5] SITAGLIPTIN
Toxicity [2]
Leukopenia [2] Ulcerations (320%) Trade names: Janumet (Merck Sharpe &
Other Vasculitis [2] Dohme), Januvia (Merck Sharpe & Dohme)
Adverse effects [9] Hair Indications: Type II diabetes mellitus
Death [5] Hirsutism (320%) Class: Antidiabetic, Dipeptidyl peptidase-4 (DPP-
4) inhibitor
Nails Half-life: 12 hours
Onychopathy [2]
SINCALIDE Mucosal
interactions with: alcohol, anabolic steroids,
See: www.drugeruptiondata.com/drug/id/1165 Aphthous stomatitis (9%) [8] beta blockers, corticosteroids, diazoxide, digoxin,
Gingival hyperplasia/hypertrophy (320%) [2] estrogens, loop diuretics, MAO inhibitors,
Gingivitis (320%) progestogens, testosterone, thiazides
Mucositis [2] Pregnancy category: B
SINECATECHINS Oral candidiasis (320%) Important contra-indications noted in the
Oral ulceration (320%) [8] prescribing guidelines for: the elderly; nursing
See: www.drugeruptiondata.com/drug/id/1300 Stomatitis (320%) [6] mothers; pediatric patients
Cardiovascular Note: Janumet is sitagliptin and metformin.
Thrombophlebitis (320%)
SIPULEUCEL-T Central Nervous System Skin
Chills (320%) Angioedema [3]
See: www.drugeruptiondata.com/drug/id/2647 Bullous pemphigoid [2]
Depression (3–20%)
Fever [2] Edema [3]
Hyperesthesia (320%) Rash [2]
SIROLIMUS Paresthesias (320%) Central Nervous System
Tremor (2131%) Headache [5]
Synonym: rapamycin
Trade name: Rapamune (Wyeth) Neuromuscular/Skeletal Neuromuscular/Skeletal
Indications: Prophylaxis of organ rejection in Arthralgia (25–31%) [3] Arthralgia [2]
renal transplants, lymphangioleiomyomatosis Asthenia (fatigue) [3] Bone or joint pain [2]
Class: Immunosuppressant, Macrolactam, Non- Myalgia/Myopathy [2] Rhabdomyolysis [4]
calcineurin inhibitor Gastrointestinal/Hepatic Gastrointestinal/Hepatic
Half-life: 62 hours Diarrhea [3] Abdominal pain (2%)
Clinically important, potentially hazardous Hepatitis [2] Constipation [3]
interactions with: atazanavir, benazepril, Hepatotoxicity [3] Diarrhea [9]
boceprevir, captopril, ceritinib, cobicistat/ Respiratory Hepatotoxicity [2]
elvitegravir/emtricitabine/tenofovir disoproxil, Cough [2] Nausea [10]
crizotinib, cyclosporine, darunavir, dasatinib, Flu-like syndrome (3–20%) Pancreatitis [9]
delavirdine, dronedarone, efavirenz, eluxadoline, Pneumonitis [7] Vomiting [6]
enalapril, enzalutamide, fosinopril, Hemophilus B Pulmonary toxicity [3] Respiratory
vaccine, indinavir, itraconazole, lisinopril, lopinavir, Upper respiratory tract infection (20–26%) Nasopharyngitis [5]
micafungin, mifepristone, posaconazole, quinapril, [2] Upper respiratory tract infection [2]
Litt’s Drug Eruption & Reaction Manual SOFOSBUVIR & VELPATASVIR
Endocrine/Metabolic Hematologic
Creatine phosphokinase increased [2] SODIUM OXYBATE Anemia (6–21%) [32]
Hypoglycemia [10] Lymphopenia [2]
Weight gain [3] See: www.drugeruptiondata.com/drug/id/919 Neutropenia (<17%) [5]
Weight loss [2] Other
Renal Adverse effects [8]
Renal failure [2] SODIUM PICOSULFATE Infection [2]
Other See: www.drugeruptiondata.com/drug/id/2988
Adverse effects [7]
Cancer [3] SOFOSBUVIR &
SODIUM THIOSULFATE VELPATASVIR
SITAXENTAN See: www.drugeruptiondata.com/drug/id/2807 Trade name: Epclusa (Gilead)
Indications: Hepatitis C
Class: Direct-acting antiviral, Hepatitis C virus
SOFOSBUVIR NS5A inhibitor (velpatasvir), Hepatitis C virus
nucleotide analog NS5B polymerase inhibitor
SMALLPOX VACCINE Trade name: Sovaldi (Gilead) (sofosbuvir)
Indications: Hepatitis C Half-life: <27 hours (sofosbuvir); 15 hours
Trade name: Dryvax (Wyeth) Class: Direct-acting antiviral, Hepatitis C virus (velpatasvir)
Indications: Prevention of smallpox (variola) nucleotide analog NS5B polymerase inhibitor Clinically important, potentially hazardous
Class: Vaccine Half-life: <27 hours interactions with: amiodarone, carbamazepine,
Half-life: ~5 years Clinically important, potentially hazardous efavirenz, omeprazole, oxcarbazepine,
Clinically important, potentially hazardous interactions with: carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin,
interactions with: corticosteroids oxcarbazepine, phenobarbital, phenytoin, rifapentine, St John’s wort, topotecan
Pregnancy category: C rifabutin, rifampin, rifapentine, ritonavir, St John’s Pregnancy category: N/A (Insufficient evidence
wort, tipranavir to inform drug-associated risk; contra-indicated in
Skin Pregnancy category: N/A (May cause fetal pregnancy when given with ribavirin)
Basal cell carcinoma [4] harm) Important contra-indications noted in the
Bullous dermatitis [2] Important contra-indications noted in the prescribing guidelines for: nursing mothers;
Carcinoma [2] prescribing guidelines for: nursing mothers; pediatric patients
Dermatitis [2] pediatric patients Note: See also separate entry for sofosbuvir.
Eczema vaccinatum [13] Note: Used in combination with daclatasvir,
Erythema multiforme [8] ledipasvir, ribavirin, velpatasvir or with PEG- Skin
Exanthems [7] interferon and ribavirin (see separate entries). Rash (2%)
Folliculitis [2] Central Nervous System
Herpes simplex [2] Skin Headache (22%) [13]
Herpes zoster [2] Pruritus (11–27%) [11] Insomnia (5%) [6]
Melanoma [2] Rash (8–18%) [9]
Photosensitivity [2] Neuromuscular/Skeletal
Purpura [11] Cardiovascular Arthralgia [2]
Rash [3] Bradyarrhythmia [2] Asthenia (fatigue) (5–15%) [13]
Scar [2] Bradycardia [2]
Stevens-Johnson syndrome [3] Central Nervous System Hepatotoxicity (2–6%)
Toxic epidermal necrolysis [5] Chills (2–18%) [2] Nausea (9%) [11]
Tumors [3] Fever (4–18%) [3]
Respiratory
Urticaria [5] Headache (24–44%) [48]
Nasopharyngitis [4]
Vaccinia [25] Insomnia (15–29%) [19]
Vaccinia gangrenosum [3] Irritability (10–16%) [5] Endocrine/Metabolic
Vaccinia necrosum [6] Vertigo (dizziness) [3] Creatine phosphokinase increased (<2%)
Central Nervous System Neuromuscular/Skeletal Hematologic
Headache [2] Arthralgia [2] Anemia [3]
Asthenia (fatigue) (30–59%) [47] Thrombocytopenia [2]
Other
Allergic reactions [2] Back pain [2]
Death [8] Myalgia/Myopathy (6–16%) [4]
SODIUM IODIDE I-131 Nausea (13–34%) [35]
Vomiting [2]
See: www.drugeruptiondata.com/drug/id/2657 Respiratory
Cough [4]
Flu-like syndrome (3–18%) [3]
SODIUM NITRITE Nasopharyngitis [2]
See: www.drugeruptiondata.com/drug/id/2797 Endocrine/Metabolic
Appetite decreased (6–18%)
SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR See all our books at www.crcpress.com
Cardiovascular Endocrine/Metabolic
SOFOSBUVIR/ QT prolongation [3] ALT increased (19%)
Appetite decreased (30%)
VELPATASVIR/ Central Nervous System
AST increased (19%)
VOXILAPREVIR * Neuromuscular/Skeletal
Creatine phosphokinase increased (61%) [7]
Asthenia (fatigue) (<2%) Hyperglycemia (51%)
Trade name: Vosevi (Gilead)
Indications: Chronic HCV infection Gastrointestinal/Hepatic Weight loss (30%) [3]
Class: Direct-acting antiviral, Hepatitis C virus Abdominal pain (2%) Hematologic
NS3/4A protease inhibitor (voxilaprevir), Constipation [11] Anemia (32%)
Hepatitis C virus NS5A inhibitor (velpatasvir), Ocular Lymphopenia (28%)
Hepatitis C virus nucleotide analog NS5B Vision blurred (45%) [5]
polymerase inhibitor (sofosbuvir) Xerophthalmia (2%)
Half-life: <29 hours (sofosbuvir); 17 hours
(velpatasvir); 33 hours (voxilaprevir)
Other SORAFENIB
Adverse effects [5]
Trade name: Nexavar (Bayer)
interactions with: amiodarone, atazanavir,
Indications: Advanced renal cell carcinoma
carbamazepine, cyclosporine, efavirenz, lopinavir,
Class: Antineoplastic, Epidermal growth factor
oxcarbazepine, phenobarbital, phenytoin, SOMATROPIN receptor (EGFR) inhibitor, Tyrosine kinase
pitavastatin, rifabutin, rifampin, rifapentine,
See: www.drugeruptiondata.com/drug/id/1035 inhibitor
ritonavir, rosuvastatin, St John’s wort, tipranavir
to inform drug-associated risk)
interactions with: bevacizumab,
Important contra-indications noted in the SONIDEGIB carbamazepine, clozapine, conivaptan, coumarins,
CYP3A4 inducers, darunavir, delavirdine,
pediatric patients Trade name: Odomzo (Novartis) dexamethasone, digoxin, docetaxel, doxorubicin,
Note: See also separate entries for sofosbuvir Indications: Basal cell carcinoma efavirenz, indinavir, irinotecan, neomycin,
and sofosbuvir & velpatasvir. Class: Hedgehog (Hh) signaling pathway inhibitor oxcarbazepine, phenobarbital, phenytoin,
Warning: RISK OF HEPATITIS B VIRUS Half-life: 28 days rifabutin, rifampin, rifapentine, St John’s wort,
REACTIVATION IN PATIENTS COINFECTED Clinically important, potentially hazardous telithromycin, voriconazole, warfarin
WITH HCV AND HBV interactions with: atazanavir, carbamazepine, Pregnancy category: D
diltiazem, efavirenz, fluconazole, itraconazole, Important contra-indications noted in the
Skin ketoconazole, modafinil, nefazodone, prescribing guidelines for: nursing mothers;
Rash (<2%) phenobarbital, phenytoin, posaconazole, rifabutin, pediatric patients
rifampin, saquinavir, St John’s wort, telithromycin, Note: In combination with carboplatin and
voriconazole paclitaxel, Nexavar is contra-indicated in patients
Headache (21–23%) [6]
Pregnancy category: N/A (Can cause fetal with squamous cell lung cancer.
Insomnia (3–6%)
harm)
Asthenia (fatigue) (6–19%) [7] prescribing guidelines for: nursing mothers; Skin
pediatric patients Acneform eruption (<10%) [6]
Gastrointestinal/Hepatic Actinic keratoses [4]
Diarrhea (13–14%) [6] Note: Patients should not donate blood or blood
products while receiving sonidegib and for at least AGEP [2]
Nausea (10–13%) [6] Desquamation (19–40%) [9]
20 months after the last dose.
Endocrine/Metabolic Warning: EMBRYO-FETAL TOXICITY Eczema [2]
Hyperbilirubinemia (4–13%) Edema [3]
Hematologic Erythema (>10%) [4]
Skin Erythema multiforme [11]
Hyperlipasemia (2–3%) Pruritus (10%) Exanthems [3]
Hair Exfoliative dermatitis (<10%)
Alopecia (53%) [6] Facial erythema [3]
SOLIFENACIN Central Nervous System Folliculitis [3]
Anorexia [2] Hand–foot syndrome (21–30%) [113]
Trade name: Vesicare (Astellas) Hyperkeratosis [4]
Indications: Overactive bladder Dysgeusia (taste perversion) (46%) [6]
Class: Antimuscarinic, Muscarinic antagonist Headache (15%)
Keratoacanthoma [4]
Half-life: 4568 hours Pain (14%)
Clinically important, potentially hazardous Vertigo (dizziness) [2]
Milia [2]
interactions with: atazanavir, carbamazepine, Neuromuscular/Skeletal Nevi [3]
clarithromycin, indinavir, itraconazole, Asthenia (fatigue) (41%) [5] Palmar–plantar toxicity [2]
ketoconazole, nefazodone, nelfinavir, Bone or joint pain (32%) Pigmentation [2]
phenobarbital, phenytoin, rifabutin, rifampin, Muscle spasm (54%) [6] Pruritus (14–19%) [10]
rifapentine, ritonavir, saquinavir, St John’s wort, Myalgia/Myopathy (19%) [5] Psoriasis [2]
troleandomycin, voriconazole Radiation recall dermatitis [3]
Pregnancy category: C Rash (19–40%) [51]
Important contra-indications noted in the Recall reaction [2]
Diarrhea (32%)
prescribing guidelines for: nursing mothers; Seborrheic dermatitis [2]
Hepatotoxicity [2]
pediatric patients Squamous cell carcinoma [8]
Nausea (39%) [4]
Vomiting (11%) [3] Stevens-Johnson syndrome [2]
Mucosal Toxicity [16]
Xerostomia (1127%) [21] Xerosis (10–11%) [6]
Litt’s Drug Eruption & Reaction Manual SPIRONOLACTONE
Hair Genitourinary Bradycardia [9]

Alopecia (14–27%) [26] Erectile dysfunction (<10%) Cardiac failure [2]
Hair pigmentation [2] Renal Cardiogenic shock [2]
Nails Proteinuria [3] Cardiotoxicity [2]
Splinter hemorrhage [4] Renal failure (<10%) [2] Hypotension [3]
Subungual hemorrhage [2] QT prolongation [18]
Hematologic Torsades de pointes [24]
Mucosal Anemia (44%) [10]
Epistaxis (nosebleed) [2] Hemorrhage (15–18%) [4] Central Nervous System
Glossodynia (<10%) Hemotoxicity [2] Depression [2]
Mucositis (<10%) [12] Leukopenia (>10%) [3] Paresthesias (3%)
Stomatitis (<10%) [13] Lymphopenia (23–47%) [5] Neuromuscular/Skeletal
Xerostomia (<10%) Myelosuppression [2] Asthenia (fatigue) (6%) [2]
Cardiovascular Neutropenia (<10%) [7] Other
Cardiac failure [2] Thrombocytopenia (12–46%) [17] Adverse effects [2]
Cardiotoxicity (3%) [3] Thrombosis [2]
Congestive heart failure (<10%) Other
Flushing (<10%)
Hypertension (9–17%) [52]
Death [9]
SPARFLOXACIN
Myocardial infarction (<10%) Infection [2] See: www.drugeruptiondata.com/drug/id/650
Central Nervous System Side effects (71%) [4]
Anorexia (16–29%) [15]
Depression (<10%)
Encephalopathy [2] SOTALOL SPECTINOMYCIN
Fever (<10%) [6] See: www.drugeruptiondata.com/drug/id/651
Headache (10%) [5] Trade name: Betapace (Bayer)
Neurotoxicity (240%) [4] Indications: Ventricular arrhythmias
Pain (>10%) [4] Class: Antiarrhythmic, Antiarrhythmic class II,
Neuromuscular/Skeletal Antiarrhythmic class III, Beta adrenergic blocker, SPINOSAD
Arthralgia (<10%) Beta blocker
Half-life: 718 hours See: www.drugeruptiondata.com/drug/id/2185
Back pain [3] Clinically important, potentially hazardous
Bone or joint pain (>10%) [3] interactions with: abarelix, amiodarone,
Myalgia/Myopathy (<10%) amisulpride, amitriptyline, arsenic, artemether/ SPIRONOLACTONE
lumefantrine, asenapine, astemizole,
Gastrointestinal/Hepatic atomoxetine, bepridil, ciprofloxacin, class I and Trade names: Aldactazide (Pfizer), Aldactone
Abdominal pain (11–31%) [9] class III antiarrhythmics, clonidine, degarelix, (Pfizer)
Ascites [2] disopyramide, dronedarone, droperidol, Indications: Hyperaldosteronism, hirsutism,
Constipation (14–15%) [4] enoxacin, gatifloxacin, guanethidine, haloperidol, hypertension, edema for patients with congestive
Diarrhea (43–55%) [64] insulin, isoprenaline, ivabradine, heart failure, cirrhosis of the liver or nephrotic
Dyspepsia (<10%) levomepromazine, lomefloxacin, loop diuretics, syndrome
Dysphagia (<10%) mizolastine, moxifloxacin, nilotinib, norfloxacin, Class: Aldosterone antagonist, Diuretic
Gastrointestinal bleeding [5] ofloxacin, oral macrolides, phenothiazines, Half-life: 7884 minutes
Hepatotoxicity (11%) [24] pimavanserin, pimozide, procainamide, quinidine, Clinically important, potentially hazardous
Nausea (23–24%) [14] quinine, quinolones, ranolazine, reserpine, interactions with: ACE inhibitors, alcohol,
Pancreatitis [7] ribociclib, salbutamol, sertindole, sparfloxacin, amiloride, barbiturates, benazepril, captopril,
Pneumatosis intestinalis [2] sulpiride, terbutaline, tetrabenazine, thiazides and cyclosporine, enalapril, fosinopril, lisinopril,
Vomiting (15–16%) [8] related diruetics, tolterodine, tricyclic mitotane, moexipril, narcotics, NSAIDs,
Respiratory antidepressants, trifluoperazine, vandetanib, potassium chloride, potassium iodide, quinapril,
Cough (13%) [2] zuclopenthixol ramipril, trandolapril, triamterene, zofenopril
Dysphonia [5] Pregnancy category: B Pregnancy category: C
Dyspnea (14%) [4] Important contra-indications noted in the Important contra-indications noted in the
Flu-like syndrome (<10%) prescribing guidelines for: nursing mothers; prescribing guidelines for: nursing mothers;
Hoarseness (<10%) pediatric patients pediatric patients
Pulmonary toxicity [2] Note: Contra-indicated in patients with bronchial Note: Aldactazide is spironolactone and
asthma, sinus bradycardia, second and third hydrochlorothiazide. Hydrochlorothiazide is a
Endocrine/Metabolic
degree AV block, unless a functioning pacemaker sulfonamide and can be absorbed systemically.
ALT increased [9]
is present, congenital or acquired long QT Sulfonamides can produce severe, possibly fatal,
Appetite decreased (<10%) [5]
syndromes, cardiogenic shock, or uncontrolled reactions such as toxic epidermal necrolysis and
AST increased [8]
congestive heart failure. Stevens-Johnson syndrome.
Creatine phosphokinase increased [2]
Warning: Spironolactone has been shown to be a
Skin tumorigen in chronic toxicity studies in rats
Hypoalbuminemia (56%)
Hypocalcemia [2] Edema (5%)
Hypokalemia [2] Pruritus (<10%) Skin
Hyponatremia [2] Psoriasis [3] Bullous pemphigoid [2]
Hypophosphatemia (35–45%) [7] Rash (3%) Dermatitis [6]
Hypothyroidism [8] Scleroderma [3] Eczema [2]
Thyroid dysfunction [4] Cardiovascular Exanthems (<5%) [6]
Weight loss (10–30%) [12] Arrhythmias [2] Lichenoid eruption [2]
Atrioventricular block [2] Melasma [2]
SPIRONOLACTONE Over 100 updates per week on www.drugeruptiondata.com
Pigmentation [3] Pregnancy category: C Other

Pruritus [3] Important contra-indications noted in the Allergic reactions (4%) [4]
Rash (<10%) [2] prescribing guidelines for: nursing mothers
Urticaria [2] Warning: LACTIC ACIDOSIS and
Xerosis (40%) [2] HEPATOMEGALY with STEATOSIS;
PANCREATITIS
STREPTOMYCIN
Hair
Alopecia [2] Trade name: Streptomycin (Pfizer)
Endocrine/Metabolic Skin Indications: Tuberculosis
Amenorrhea [2] Diaphoresis (19%) Class: Antibiotic, aminoglycoside
Gynecomastia [29] Lipoatrophy [7] Half-life: 25 hours
Hyperkalemia [9] Lipodystrophy [8] Clinically important, potentially hazardous
Rash (40%) interactions with: aldesleukin, aminoglycosides,
Renal Toxic epidermal necrolysis [2] atracurium, bacitracin, bumetanide, doxacurium,
Renal function abnormal [2] Toxicity [2] ethacrynic acid, furosemide, methoxyflurane,
Central Nervous System neostigmine, non-depolarizing muscle relaxants,
Chills (50%) pancuronium, polypeptide antibiotics,
STANOZOLOL Neurotoxicity [4] rocuronium, succinylcholine, teicoplanin,
Peripheral neuropathy (52%) [11] torsemide, vecuronium
Trade name: Winstrol (Ovation) Pregnancy category: D
Indications: Hereditary angioedema Neuromuscular/Skeletal Important contra-indications noted in the
Class: Anabolic steroid Myalgia/Myopathy (32%) [2] prescribing guidelines for: nursing mothers
Half-life: N/A Gastrointestinal/Hepatic Note: Aminoglycosides may cause neurotoxicity
Clinically important, potentially hazardous Diarrhea (50%) and/or nephrotoxicity.
interactions with: anticoagulants, warfarin Hepatotoxicity [2]
Pregnancy category: X Nausea (39%) Skin
Important contra-indications noted in the Pancreatitis [6] Anaphylactoid reactions/Anaphylaxis [3]
prescribing guidelines for: nursing mothers Vomiting (39%) Dermatitis [2]
Endocrine/Metabolic DRESS syndrome [3]
Skin Acidosis [11] Erythema multiforme [4]
Acneform eruption (>10%) [2] Diabetes mellitus [2] Exanthems (>5%) [8]
Pigmentation (<10%) Fat distribution abnormality [4] Exfoliative dermatitis [11]
Hair Gynecomastia [4] Lupus erythematosus [5]
Hirsutism (in women) [3] Renal Nicolau syndrome [2]
Fanconi syndrome [2] Photosensitivity [2]
Cardiovascular Pruritus [2]
Cardiomyopathy [2] Other Purpura [3]
Hypertension [2] Adverse effects [3] Stevens-Johnson syndrome [3]
Myocardial infarction [2] Allergic reactions (9%) Toxic epidermal necrolysis [9]
Myocardial ischemia [2] Urticaria [3]
Central Nervous System Mucosal
Chills (<10%) STREPTOKINASE Cheilitis (2%)
Gastrointestinal/Hepatic Glossitis (2%)
Hepatotoxicity [3] Trade names: Kabikinase (Pfizer), Streptase Oral mucosal eruption [2]
(AstraZeneca) Stomatitis [2]
Endocrine/Metabolic Indications: Pulmonary embolism, acute
Gynecomastia (>10%) myocardial infarction Renal
Genitourinary Class: Fibrinolytic Nephrotoxicity [2]
Priapism (>10%) Half-life: 83 minutes Otic
Renal Clinically important, potentially hazardous Ototoxicity [6]
Nephrotoxicity [3] interactions with: bivalirudin, lepirudin Ocular
Pregnancy category: C Optic neuropathy [2]
Other
Death [3] Other
Anaphylactoid reactions/Anaphylaxis [2] Allergic reactions [2]
Angioedema (>10%) [2]
STAVUDINE Diaphoresis (<10%)
Exanthems (<5%) [2]
Synonym: D4T Pruritus (<10%) STREPTOZOCIN
Trade name: Zerit (Bristol-Myers Squibb) Purpura [2]
Indications: HIV infection Rash (<10%) Trade name: Zanosar (Gensia)
Class: Antiretroviral, Nucleoside analog reverse Serum sickness [4] Indications: Carcinoma of the pancreas,
transcriptase inhibitor Serum sickness-like reaction [3] carcinoid tumor, Hodgkin’s disease
Half-life: 1.44 hours Urticaria (<5%) Class: Alkylating agent, Antineoplastic
Clinically important, potentially hazardous Vasculitis [7] Half-life: 35 minutes
interactions with: doxorubicin, ribavirin, Clinically important, potentially hazardous
zidovudine Neuromuscular/Skeletal interactions with: aldesleukin
Rhabdomyolysis [2] Pregnancy category: D
Ocular Important contra-indications noted in the
Periorbital edema (>10%) prescribing guidelines for: nursing mothers
Litt’s Drug Eruption & Reaction Manual SUGAMMADEX
Neuromuscular/Skeletal Mucosal
Asthenia (fatigue) [2] SUCCINYLCHOLINE Xerostomia [2]
Gastrointestinal/Hepatic Synonym: suxamethonium Gastrointestinal/Hepatic
Abdominal pain [2] Trade name: Anectine (Sabex) Constipation (2%)
Nausea [2] Indications: Skeletal muscle relaxation during
Vomiting [2] general anesthesia
Renal Class: Cholinesterase inhibitor, Depolarizing SUCRALOSE
Nephrotoxicity [2] muscle relaxant
Hematologic Half-life: N/A Trade name: Splenda (McNeil)
Neutropenia [2] Clinically important, potentially hazardous Indications: Weight reduction
interactions with: amikacin, aminoglycosides, Class: Sweetening agent
Local donepezil, galantamine, gentamicin, Half-life: 25 hours
Injection-site pain (<10%) hydromorphone, kanamycin, levomepromazine, Clinically important, potentially hazardous
neomycin, neostigmine, paromomycin, interactions with: none known
physostigmine, pipecuronium, pralidoxime, Pregnancy category: N/A
STRONTIUM quinine, streptomycin, tapentadol, thalidomide,
tobramycin, vancomycin, vecuronium Central Nervous System
RANELATE Pregnancy category: C Migraine [3]
See: www.drugeruptiondata.com/drug/id/1386 prescribing guidelines for: the elderly; nursing
mothers
Warning: RISK OF CARDIAC ARREST FROM SUFENTANIL
SUCCIMER HYPERKALEMIC RHABDOMYOLYSIS
Synonym: DMSA Skin
Trade name: Chemet (Sanofi-Aventis) Anaphylactoid reactions/Anaphylaxis [13]
Indications: Heavy metal poisoning
Mucosal
SUGAMMADEX
Class: Chelator
Sialorrhea (<10%) Trade name: Bridion (Organon)
Half-life: 2 days
Clinically important, potentially hazardous Cardiovascular Indications: Reversal of neuromuscular blockade
interactions with: other chelating agents Bradycardia [2] induced by rocuronium bromide and vecuronium
Pregnancy category: C Central Nervous System bromide in adults undergoing surgery
Important contra-indications noted in the Malignant hyperthermia [7] Class: Cyclodextrin, Selective relaxant binding
prescribing guidelines for: nursing mothers; Paralysis [3] agent
pediatric patients Twitching [4] Half-life: ~2 hours
Neuromuscular/Skeletal interactions with: toremifene
Skin Myalgia/Myopathy [11] Pregnancy category: N/A (No data available)
Candidiasis (16%) Rhabdomyolysis [26] Important contra-indications noted in the
Exanthems (11%)
Pruritus (11%)
Endocrine/Metabolic prescribing guidelines for: the elderly; nursing
Hyperkalemia [8] mothers; pediatric patients
Rash (<11%) [2]
Mucosal Other
Death [3] Skin
Mucocutaneous eruption (11%)
Central Nervous System Erythema (<2%)
Chills (16%) Hypersensitivity [7]
Dysgeusia (taste perversion) (metallic) SUCRALFATE Pruritus (2–3%)
(21%)
Trade name: Carafate (Aptalis) Mucosal
Fever (16%)
Indications: Duodenal ulcer Oropharyngeal pain (3–5%)
Headache (16%)
Class: Chelator Xerostomia (<2%) [2]
Pain (3%)
Half-life: N/A Cardiovascular
Paresthesias (13%)
Clinically important, potentially hazardous Bradycardia (<5%)
Neuromuscular/Skeletal interactions with: anagrelide, chlortetracycline, QT prolongation (<6%) [2]
Back pain (16%) ciprofloxacin, clorazepate, demeclocycline, Tachycardia (2–5%)
Gastrointestinal/Hepatic doxycycline, gemifloxacin, ketoconazole,
lansoprazole, levofloxacin, lomefloxacin, Central Nervous System
lymecycline, minocycline, moxifloxacin, Anxiety (<3%)
Respiratory Chills (3–7%)
norfloxacin, ofloxacin, oxtriphylline,
Flu-like syndrome (16%) Depression (<2%)
oxytetracycline, paricalcitol, phenytoin,
sparfloxacin, tetracycline, tigecycline, Dysgeusia (taste perversion) [3]
voriconazole Fever (5–9%)
Pregnancy category: B Headache (5–10%) [2]
Important contra-indications noted in the Hypoesthesia (<3%)
prescribing guidelines for: the elderly; nursing Insomnia (2–5%)
mothers; pediatric patients Pain (36–52%)
Note: Sucralfate use can lead to symptoms of Restlessness (<2%)
aluminum toxicity. Somnolence (drowsiness) [2]
Vertigo (dizziness) (3–6%)
SUGAMMADEX See all our books at www.crcpress.com
Neuromuscular/Skeletal Vertigo (dizziness) [2] Other

Bone or joint pain (<2%) Neuromuscular/Skeletal Allergic reactions [2]
Myalgia/Myopathy (<2%) Asthenia (fatigue) [2] Side effects (2%) [2]
Pain in extremities (<6%)
Gastrointestinal/Hepatic Diarrhea [2]
Other
SULFASALAZINE
Diarrhea [2]
Flatulence (<3%) Death [7] Synonyms: salicylazosulfapyridine; salazopyrin
Nausea (23–26%) [3] Trade name: Azulfidine (Pfizer)
Vomiting (11–15%) [2] Indications: Inflammatory bowel disease,
Respiratory SULFA- ulcerative colitis, rheumatoid arthritis
Bronchospasm [2] Class: Aminosalicylate, Disease-modifying
Cough (<8%)
METHOXAZOLE antirheumatic drug (DMARD), Sulfonamide
Endocrine/Metabolic Trade names: Bactrim (Women First), Septra Clinically important, potentially hazardous
Creatine phosphokinase increased (<2%) (Monarch) interactions with: cholestyramine,
Hypocalcemia (<2%) Indications: Various infections caused by methotrexate, safinamide
Hematologic susceptible organisms Pregnancy category: B
Anemia (<2%) Class: Antibiotic, sulfonamide, Folic acid Important contra-indications noted in the
antagonist prescribing guidelines for: nursing mothers;
Local Half-life: 712 hours pediatric patients
Injection-site pain (4–6%) Clinically important, potentially hazardous Note: Sulfasalazine is a sulfonamide and can be
Other interactions with: anticoagulants, azathioprine, absorbed systemically. Sulfonamides can produce
Allergic reactions [2] cyclosporine, methotrexate, pralatrexate, severe, possibly fatal, reactions such as toxic
probenecid, warfarin epidermal necrolysis and Stevens-Johnson
Pregnancy category: C syndrome.
SULFACETAMIDE Note: Sulfamethoxazole is a sulfonamide and can
be absorbed systemically. Sulfonamides can
Contra-indicated in patients with intestinal or
urinary obstruction, or with porphyria.
See: www.drugeruptiondata.com/drug/id/894 produce severe, possibly fatal, reactions such as
toxic epidermal necrolysis and Stevens-Johnson
syndrome.
Skin
Sulfamethoxazole is commonly used in
AGEP [3]
SULFADIAZINE conjunction with trimethoprim (see separate
entry for co-trimoxazole).
Angioedema [3]
See: www.drugeruptiondata.com/drug/id/661 Bullous pemphigoid [3]
Cyanosis (<10%)
Skin Dermatitis [2]
AGEP [3] DRESS syndrome [31]
SULFADOXINE Anaphylactoid reactions/Anaphylaxis [4] Erythema multiforme [8]
Angioedema (<5%) Erythema nodosum [2]
Trade name: Fansidar (Roche) Dermatitis [4]
Indications: Malaria
Exanthems (223%) [23]
DRESS syndrome [4] Exfoliative dermatitis [5]
Class: Antibiotic, sulfonamide, Antimalarial Erythema multiforme [15]
Half-life: 58 days
Fixed eruption [7]
Erythema nodosum [2] Hypersensitivity (<5%) [21]
Clinically important, potentially hazardous Exanthems (<5%) [30]
Lichen planus [3]
Exfoliative dermatitis [3] Lupus erythematosus [34]
Pregnancy category: C Fixed eruption [29]
Photosensitivity (10%) [4]
Hypersensitivity [6] Pigmentation [3]
prescribing guidelines for: the elderly; nursing Linear IgA bullous dermatosis [3]
Pruritus (10%) [8]
Lupus erythematosus [3] Pseudolymphoma [2]
Note: Sulfadoxine is a sulfonamide and can be Photosensitivity (>10%) [3]
Pustules [2]
Pruritus (10%) [7] Rash (>10%) [19]
severe, possibly fatal, reactions such as toxic Purpura [3]
epidermal necrolysis and Stevens-Johnson
Raynaud’s phenomenon [3]
Pustules [6] Stevens-Johnson syndrome [9]
syndrome. Radiation recall dermatitis [3]
Fansidar is sulfadoxine and pyrimethamine (this
Toxic epidermal necrolysis (<10%) [13]
Rash (>10%) [3] Urticaria (<5%) [11]
combination is almost always prescribed). Stevens-Johnson syndrome (<10%) [22] Vasculitis [4]
Skin Toxic epidermal necrolysis (<10%) [32] Hair
Erythema multiforme [3] Urticaria [9] Alopecia [6]
Exfoliative dermatitis [3] Vasculitis [6] Mucosal
Fixed eruption [2] Mucosal Mucocutaneous reactions (6%) [2]
Hypersensitivity (>10%) Oral mucosal eruption [2] Oral mucosal eruption [4]
Photosensitivity (>10%) [2] Oral ulceration [2] Oral ulceration [3]
Pruritus [2] Stomatitis (<10%)
Stevens-Johnson syndrome (<10%) [24] Neuromuscular/Skeletal
Rhabdomyolysis [4] Cardiovascular
Toxic epidermal necrolysis [17] Flushing [2]
Mucosal Renal
Nephrotoxicity [2] Central Nervous System
Glossitis (>10%) Anorexia (10%)
Central Nervous System Hematologic Aseptic meningitis [3]
Tremor (>10%) Thrombocytopenia [2] Fever [4]
Litt’s Drug Eruption & Reaction Manual SUNITINIB
Headache (10%) [7] Purpura [2] Neurotoxicity [3]

Vertigo (dizziness) (<10%) Rash (>10%) Pain (<2%) [2]
Neuromuscular/Skeletal Stevens-Johnson syndrome [5] Paresthesias (3–5%) [11]
Arthralgia [2] Toxic epidermal necrolysis [13] Somnolence (drowsiness) [3]
Asthenia (fatigue) [5] Urticaria [4] Stroke [2]
Mucosal Vertigo (dizziness) (<2%) [10]
Gastrointestinal/Hepatic Warm feeling (2–3%)
Abdominal pain (<10%) Oral mucosal eruption (3%) [2]
Dyspepsia (10%) [3] Stomatitis [2] Neuromuscular/Skeletal
Hepatotoxicity [14] Xerostomia [2] Asthenia (fatigue) (2–3%) [5]
Nausea (10%) [7] Gastrointestinal/Hepatic Jaw pain (<3%)
Pancreatitis [6] Hepatotoxicity [4] Muscle spasm [2]
Vomiting (10%) [2] Pancreatitis [3] Myalgia/Myopathy (2%) [2]
Neck pain (<3%)
Respiratory
Pulmonary toxicity [3] Gastrointestinal/Hepatic
Upper respiratory tract infection [3] SULPIRIDE Colitis [2]
Nausea [12]
Renal
Nephrotoxicity [4] See: www.drugeruptiondata.com/drug/id/1351 Respiratory
Renal failure [2] Nasopharyngitis [2]
Hematologic
Agranulocytosis [5] SUMATRIPTAN Local
Anemia (<10%) Application-site erythema [2]
Leukopenia (<10%) [4] Trade names: Alsuma (King), Imigran (GSK), Injection-site reactions (1058%) [2]
Neutropenia [2] Imitrex (GSK), Onzetra Xsail (Avanir), Sumavel Other
Thrombocytopenia (<10%) DosePro (Endo), Zecuity (Teva) Adverse effects [10]
Indications: Migraine attacks, cluster headaches
Ocular Class: 5-HT1 agonist, Serotonin receptor agonist,
Conjunctival pigmentation [2] Triptan
Other Half-life: 2.5 hours SUNITINIB
Adverse effects [9] Clinically important, potentially hazardous
Death [4] interactions with: citalopram, Trade name: Sutent (Pfizer)
Side effects (5%) dihydroergotamine, ergot-containing drugs, Indications: Gastrointestinal stromal tumor,
escitalopram, fluoxetine, fluvoxamine, advanced renal cell carcinoma, advanced
isocarboxazid, MAO inhibitors, methysergide, pancreatic neuroendocrine tumor
naratriptan, nefazodone, paroxetine Class: Antineoplastic, Epidermal growth factor
SULFINPYRAZONE hydrochloride, phenelzine, rizatriptan, sertraline, receptor (EGFR) inhibitor, Tyrosine kinase
sibutramine, SNRIs, SSRIs, St John’s wort, inhibitor
See: www.drugeruptiondata.com/drug/id/665 Half-life: 4060 hours
tranylcypromine, venlafaxine, zolmitriptan
Pregnancy category: C Clinically important, potentially hazardous
Important contra-indications noted in the interactions with: atazanavir, bevacizumab,
SULFISOXAZOLE prescribing guidelines for: the elderly; nursing carbamazepine, clarithromycin, clozapine,
mothers; pediatric patients dexamethasone, digoxin, efavirenz, grapefruit
See: www.drugeruptiondata.com/drug/id/666 Note: Contra-indicated in patients with Wolff- juice, indinavir, itraconazole, ketoconazole,
Parkinson-White syndrome, peripheral vascular nefazodone, nelfinavir, phenobarbital, phenytoin,
disease, ischemic bowel disease, uncontrolled rifabutin, rifampin, rifapentine, ritonavir,
SULINDAC hypertension, severe hepatic impairment or a saquinavir, St John’s wort, telithromycin,
temsirolimus, voriconazole
history of coronary artery disease, coronary
Trade name: Clinoril (Merck) vasospasm, stroke, transient ischemic attack, or Pregnancy category: D
Indications: Arthritis hemiplegic or basilar migraine; or with recent Important contra-indications noted in the
Class: Non-steroidal anti-inflammatory (NSAID) (within 24 hours) use of another 5-HT1 agonist prescribing guidelines for: nursing mothers;
Half-life: 7.816.4 hours (e.g. another triptan) or an ergotamine-containing pediatric patients
Clinically important, potentially hazardous medication, or current or recent (past 2 weeks) Note: [G] = treated for gastrointestinal tumor;
interactions with: methotrexate, warfarin use of a monoamine oxidase-A inhibitor. [R] = treated for renal cell carcinoma; [P] treated
Pregnancy category: C (category C in first and for pancreatic neuroendocrine tumor.
second trimesters; category D in third trimester) Warning: HEPATOTOXICITY
Skin
Important contra-indications noted in the Burning (<10%)
prescribing guidelines for: nursing mothers; Diaphoresis (2%) Skin
pediatric patients Hot flashes (>10%) Acral erythema [2]
Note: NSAIDs may cause an increased risk of Edema [6]
serious cardiovascular and gastrointestinal Mucosal Erythema [6]
adverse events, which can be fatal. This risk may Nasal discomfort [2] Facial edema [3]
increase with duration of use. Xerostomia [2] Hand–foot syndrome (1214%) [68]
Cardiovascular Lesions [2]
Skin Chest pain (<2%) [7] Nevi [2]
Anaphylactoid reactions/Anaphylaxis [4] Flushing (7%) [4] Peripheral edema [R] (17%)
Erythema multiforme [8] Hypertension [2] Pigmentation [14]
Exanthems (<5%) [9] Myocardial infarction [5] Pruritus [R] [3]
Fixed eruption [5] Central Nervous System Pyoderma gangrenosum [8]
Photosensitivity [2] Dysgeusia (taste perversion) [10] Rash (1438%) [17]
Pruritus (<10%) [5] Headache [2] Thrombocytopenic purpura [4]
SUNITINIB Over 100 updates per week on www.drugeruptiondata.com
Toxicity [24] Gastrointestinal/Hepatic Thrombocytopenia [39]

Xerosis (17%) [3] Abdominal pain (2033%) [2] Ocular
Hair Constipation [3] Epiphora [R] (6%)
Alopecia (512%) [5] Diarrhea [36] Periorbital edema [R] (7%)
Hair pigmentation [G] [8] Dyspepsia [R] [P] [3]
Esophagitis [2] Other
Nails Gastrointestinal bleeding [4] Adverse effects [17]
Splinter hemorrhage [2] Gastrointestinal disorder [2] Death [7]
Subungual hemorrhage [4] Hepatotoxicity [7] Side effects [3]
Mucosal Nausea [17]
Epistaxis (nosebleed) [2] Pneumatosis intestinalis [2]
Glossodynia [R] [P] (15%) Vomiting [14] SUVOREXANT
Mucosal inflammation [4] Respiratory
Mucositis (2953%) [18] Cough [R] (817%) [2] Trade name: Belsomra (Merck Sharpe &
Stomatitis [17] Dyspnea [5] Dohme)
Xerostomia [R] [P] [2] Pulmonary toxicity [3] Indications: Insomnia
Cardiovascular Radiation recall pneumonitis [2] Class: Orexin receptor antagonist
Aortic dissection [3] Half-life: 10–22 hours
Endocrine/Metabolic Clinically important, potentially hazardous
Cardiac failure [2] ALT increased [4]
Cardiomyopathy [2] interactions with: none known
Appetite decreased [2] Pregnancy category: C
Cardiotoxicity [7] AST increased [2]
Congestive heart failure [2] Important contra-indications noted in the
Hypothyroidism [R] [29] prescribing guidelines for: nursing mothers;
Hypertension [56] Serum creatinine increased [2]
QT prolongation [2] pediatric patients
Thyroid dysfunction [8] Note: Contra-indicated in patients with
Ventricular arrhythmia [2]
Renal narcolepsy.
Central Nervous System Nephrotoxicity [4]
Anorexia [8] Proteinuria [3]
Dysgeusia (taste perversion) (2143%) [6] Mucosal
Fever [R] (1518%) [2] Hematologic Xerostomia (2%)
Headache (1325%) [4] Anemia [20] Central Nervous System
Leukoencephalopathy [3] Bleeding [5] Abnormal dreams (2%) [2]
Neurotoxicity [R] (10%) Bone marrow suppression [2] Headache (7%) [2]
Pain [R] (18%) Cytopenia [2] Sedation [2]
Vertigo (dizziness) [R] (16%) Hemorrhage [2] Somnolence (drowsiness) (7%) [6]
Hemotoxicity [3] Vertigo (dizziness) (3%)
Neuromuscular/Skeletal Hyperlipasemia [2]
Arthralgia [R] (1228%) Leukopenia [16] Gastrointestinal/Hepatic
Asthenia (fatigue) (22%) [69] Lymphocytopenia [2] Diarrhea (2%)
Back pain [R] (1117%) Lymphopenia [8] Respiratory
Myalgia/Myopathy [G] (1417%) Myelosuppression [3] Cough (2%)
Osteonecrosis [3] Neutropenia [44] Upper respiratory tract infection (2%)
Litt’s Drug Eruption & Reaction Manual TADALAFIL
Rosacea [5] Hematologic

TACRINE Thrombocytopenic purpura [2] Anemia (>10%) [2]
Toxicity [3] Angiopathy [4]
See: www.drugeruptiondata.com/drug/id/669 Dyslipidemia [3]
Hair
Alopecia (>3%) [6] Hemolytic anemia [2]
Hypertrichosis [2] Hemolytic uremic syndrome [18]
TACROLIMUS Mucosal
Leukopenia (>10%) [5]
Neutropenia [3]
Trade names: Envarsus XR (Veloxis), Prograf Gingival hyperplasia/hypertrophy [6] Thrombotic microangiopathy [5]
(Astellas), Protopic (Astellas) Oral candidiasis (>3%)
Oral pigmentation [2] Otic
Indications: Prophylaxis of organ rejection, Tinnitus [2]
atopic dermatitis (topical) Oral ulceration [2]
Class: Calcineurin inhibitor, Immunosuppressant, Cardiovascular Ocular
Macrolactam Cardiomyopathy [3] Diplopia [2]
Half-life: ~8.7 hours Flushing [4] Ocular burning [3]
Clinically important, potentially hazardous Hypertension (49%) [8] Optic neuropathy [2]
interactions with: abatacept, afatinib, alefacept, QT prolongation [2] Vision blurred [2]
amiodarone, amprenavir, atazanavir, azacitidine, Vision loss [3]
beta blockers, betamethasone, boceprevir, Encephalopathy [10] Local
bosentan, cabazitaxel, caspofungin, ceritinib, Fever (>10%) [2] Application-site burning [6]
cinacalcet, cobicistat/elvitegravir/emtricitabine/ Headache [9] Application-site erythema [3]
tenofovir disoproxil, crizotinib, cyclosporine, Leukoencephalopathy [14] Application-site infection [2]
CYP3A4 inhibitors and inducers, dabigatran, dairy Neurotoxicity [10] Application-site irritation [2]
products, danazol, darunavir, dasatinib, Pain [2] Application-site pruritus [7]
delavirdine, denileukin, dexlansoprazole, Paresthesias (40%) [4] Other
diclofenac, docetaxel, dronedarone, efavirenz, Parkinsonism [2] Adverse effects [13]
elbasvir & grazoprevir, eluxadoline, enzalutamide, Seizures (<10%) [4] Cancer [2]
erythromycin, etoricoxib, fingolimod, gefitinib, Tremor (>10%) [9] Infection (>10%) [15]
grapefruit juice, Hemophilus B vaccine, HMG- Vertigo (dizziness) [3]
CoA reductase inhibitors, ibuprofen,
immunosuppressants, indinavir, irbesartan, Neuromuscular/Skeletal
itraconazole, ketoconazole, leflunomide, Arthralgia (>10%) [2] TADALAFIL
lenalidomide, lopinavir, lovastatin, meloxicam, Asthenia (fatigue) (>10%) [3]
mifepristone, mycophenolate, nelfinavir, Back pain (>10%) Trade names: Adcirca (Lilly), Cialis (Lilly)
nifedipine, olmesartan, omeprazole, oxaliplatin, Bone or joint pain [2] Indications: Erectile dysfunction, pulmonary
pazopanib, pemetrexed, posaconazole, Myalgia/Myopathy (>3%) arterial hypertension
potassium, potassium-sparing diuretics, Gastrointestinal/Hepatic Class: Phosphodiesterase type 5 (PDE5) inhibitor
pralatrexate, ribociclib, rifabutin, rifampin, Abdominal pain [3] Half-life: 15–18 hours
rifapentine, sevelamer, simvastatin, sirolimus, St Constipation (>10%) Clinically important, potentially hazardous
John’s wort, telaprevir, telithromycin, Diarrhea (>10%) [5] interactions with: alcohol, alfuzosin, alpha
temsirolimus, tinidazole, tipranavir, tofacitinib, Dyspepsia (>10%) blockers, amlodipine, amyl nitrite, angiotensin II
triamcinolone, vaccines, voriconazole Dysphagia (>3%) receptor blockers, antifungals, antihypertensives,
Pregnancy category: C Hepatotoxicity [11] atazanavir, bendroflumethiazide, boceprevir,
Important contra-indications noted in the Nausea (>10%) [3] bosentan, clarithromycin, cobicistat/elvitegravir/
prescribing guidelines for: the elderly; nursing Pancreatitis [3] emtricitabine/tenofovir alafenamide, cobicistat/
mothers; pediatric patients Vomiting (>10%) elvitegravir/emtricitabine/tenofovir disoproxil,
Warning: MALIGNANCIES AND SERIOUS conivaptan, CYP3A4 inhibitors or inducers,
Respiratory darunavir, dasatinib, delavirdine, disopyramide,
INFECTIONS Cough (>10%) doxazosin, efavirenz, enalapril, erythromycin,
Dyspnea (>10%) etravirine, fosamprenavir, grapefruit juice,
Skin Pulmonary toxicity [2] indinavir, itraconazole, ketoconazole, lopinavir,
Anaphylactoid reactions/Anaphylaxis [3] Endocrine/Metabolic macrolide antibiotics, metoprolol, nelfinavir,
Burning (46%) [13] Creatine phosphokinase increased (>10%) nicorandil, nitrates, nitroglycerin, nitroprusside,
Dermatitis [2] [3] oxcarbazepine, phosphodiesterase 5 inhibitors,
Diaphoresis (>3%) Diabetes mellitus [6] rifampin, rifapentine, riociguat, ritonavir,
Ecchymoses (>3%) Diabetic ketoacidosis [5] sapropterin, saquinavir, St John’s wort,
Edema (>10%) Gynecomastia [3] tamsulosin, telaprevir, telithromycin, voriconazole
Erythema (12%) [3] Hyperglycemia [10] Pregnancy category: B (Cialis is not indicated
Exanthems (4%) [2] Hyperkalemia [3] for use in women)
Folliculitis (10%) [2] Hyperlipidemia [2] Important contra-indications noted in the
Graft-versus-host reaction [2] Hypomagnesemia (>10%) [2] prescribing guidelines for: pediatric patients
Herpes simplex (13%) [4] Hypophosphatemia (>10%)
Kaposi’s sarcoma [2] SIADH [2]
Kaposi’s varicelliform eruption [2] Skin
Lymphoma [2] Genitourinary Diaphoresis (<2%)
Peripheral edema (26%) Urinary tract infection [2] Facial edema (<2%)
Photosensitivity (>3%) Renal Peripheral edema [2]
Pigmentation [2] Nephrotoxicity [42] Pruritus (<2%)
Pruritus (2536%) [11] Renal failure [2] Rash (<2%)
Pustules (6%) Renal function abnormal [3] Mucosal
Rash (24%) [2] Epistaxis (nosebleed) (<2%) [2]
TADALAFIL See all our books at www.crcpress.com
Nasal congestion [4] Pregnancy category: N/A (Contraception

Rectal hemorrhage (<2%) TAFLUPROST advised to prevent pregnancy during treatment)
Xerostomia (<2%) Important contra-indications noted in the
Trade names: Saflutan (Merck Sharpe & prescribing guidelines for: nursing mothers;
Cardiovascular Dohme), Zioptan (Merck Sharpe & Dohme)
Angina (<2%) pediatric patients
Indications: Reduction of elevated intraocular
Chest pain (<2%) pressure in open angle glaucoma or ocular
Flushing (23%) [16] hypertension Skin
Hypotension (<2%) Class: Antiglaucoma, Prostaglandin analog Cellulitis (<5%) [3]
Myocardial infarction (<2%) Half-life: 0.5 hours Herpes (oral) (<5%)
Palpitation (<2%) Clinically important, potentially hazardous Vitiligo (<5%)
Postural hypotension (<2%) interactions with: none known Mucosal
Tachycardia (<2%) Pregnancy category: C Oropharyngeal pain (6%)
Central Nervous System Important contra-indications noted in the Central Nervous System
Amnesia [3] prescribing guidelines for: nursing mothers; Chills (49%) [4]
Headache (415%) [36] pediatric patients Fever (43%) [3]
Hyperesthesia (<2%) Headache (19%)
Hypoesthesia (<2%) Central Nervous System Vertigo (dizziness) (10%)
Insomnia (<2%) Headache (6%)
Pain (<3%) Neuromuscular/Skeletal
Paresthesias (<2%) Respiratory Arthralgia (17%)
Somnolence (drowsiness) (<2%) Cough (3%) Asthenia (fatigue) (50%) [4]
Syncope (<2%) Genitourinary Myalgia/Myopathy (18%)
Vertigo (dizziness) (<2%) [6] Urinary tract infection (2%) Pain in extremities (16%)
Neuromuscular/Skeletal Ocular Gastrointestinal/Hepatic
Arthralgia (<2%) Cataract (3%) Abdominal pain (9%)
Asthenia (fatigue) (<2%) Conjunctival hyperemia (4–20%) [7] Constipation (12%)
Back pain (26%) [21] Conjunctivitis (5%) Diarrhea (19%)
Myalgia/Myopathy (<4%) [15] Deepening of upper lid sulcus [4] Nausea (36%)
Neck pain (<2%) Eyelashes – hypertrichosis (2%) Vomiting (21%)
Gastrointestinal/Hepatic Eyelashes – pigmentation (2%) [2] Respiratory
Diarrhea [2] Eyelid erythema (<10%) Flu-like syndrome (31%) [2]
Dyspepsia [8] Eyelid pigmentation [3] Endocrine/Metabolic
Dysphagia (<2%) Keratoconjunctivitis (<10%) Weight loss (6%)
Esophagitis (<2%) Lacrimation (<10%)
Ocular burning [3] Renal
Gastritis (<2%) Glomerulonephritis (<5%)
Gastroesophageal reflux (<2%) Ocular hyperemia [2]
Hepatotoxicity [2] Ocular itching [5] Local
Loose stools (<2%) Ocular pain (3%) Injection-site pain (28%)
Nausea (<2%) [3] Ocular pigmentation (<10%)
Vomiting (<2%) Ocular pruritus (5%) [2]
Ocular stinging (7%) [4] TAMOXIFEN
Respiratory Photophobia (<10%)
Dyspnea (<2%) Vision blurred (2%)
Pharyngitis (<2%) Trade name: Nolvadex (AstraZeneca)
Visual disturbances (<10%) Indications: Advanced breast cancer
Endocrine/Metabolic Xerophthalmia (3%) Class: Selective estrogen receptor modulator
GGT increased (<2%) Other (SERM)
Genitourinary Adverse effects [5] Half-life: 5–7 days
Erection (<2%) Clinically important, potentially hazardous
Priapism (spontaneous) (<2%) [2] interactions with: anastrozole, bexarotene,
Hematologic TALIGLUCERASE cinacalcet, delavirdine, droperidol, duloxetine,
gadobenate, paroxetine hydrochloride,
Anemia [2]
Platelets decreased [2] See: www.drugeruptiondata.com/drug/id/2927 rifapentine, terbinafine, tipranavir
Otic Important contra-indications noted in the
Hearing loss (<2%) [4] prescribing guidelines for: nursing mothers;
Tinnitus (<2%) TALIMOGENE pediatric patients
Ocular
Chorioretinopathy [2]
LAHERPAREPVEC
Skin
Conjunctival hyperemia (<2%) Synonym: T-VEC Carcinosarcoma [2]
Conjunctivitis (<2%) Trade name: Imlygic (Amgen) Diaphoresis [4]
Dyschromatopsia (<2%) Indications: Unresectable cutaneous, Edema (26%) [3]
Eyelid edema (<2%) subcutaneous, and nodal lesions in patients with Exanthems (3%) [3]
Eyelid pain (<2%) melanoma recurrent after initial surgery Hot flashes [18]
Lacrimation (<2%) Class: Oncolytic virus immunotherapy Lupus erythematosus [2]
Optic neuropathy [7] Half-life: N/A Pruritus ani et vulvae [2]
Vision blurred (<2%) Clinically important, potentially hazardous Radiation recall dermatitis [6]
Other interactions with: none known Rash (<10%) [2]
Adverse effects [4] Sarcoma [9]
Toxicity [3]
Litt’s Drug Eruption & Reaction Manual TARTRAZINE
Tumors [3]
Vasculitis [5] TAMSULOSIN TAPENTADOL
Xerosis (7%)
Trade names: Flomax (Boehringer Ingelheim), Trade names: Nucynta (Janssen), Nucynta ER
Hair Jalyn (GSK) (Janssen), Palexia (Grunenthal)
Alopecia [7] Indications: Benign prostatic hypertrophy Indications: Immediate release formulation:
Hirsutism [2] Class: Adrenergic alpha-receptor antagonist moderate to severe acute pain, extended release
Mucosal Half-life: 913 hours formulation: moderate to severe chronic pain and
Stomatitis [2] Clinically important, potentially hazardous neuropathic pain associated with diabetic
Xerostomia (7%) [2] interactions with: alpha adrenergic blockers, peripheral neuropathy when a continuous
Cardiovascular cimetidine, conivaptan, darunavir, delavirdine, analgesic is needed for an extended period of
Flushing (>10%) [9] erythromycin, indinavir, ketoconazole, paroxetine time
Myocardial ischemia [2] hydrochloride, phosphodiesterase 5 inhibitors, Class: Analgesic, opioid
QT prolongation [3] tadalafil, telithromycin, terbinafine, vardenafil, Half-life: 5 hours
Thromboembolism [6] voriconazole, warfarin Clinically important, potentially hazardous
Thrombophlebitis [3] Pregnancy category: B (not indicated for use in interactions with: alcohol, alvimopan,
Venous thromboembolism [6] women; Jalyn is pregnancy category X) amphetamines, anesthestics, anitemetics,
Important contra-indications noted in the anticholinergics, buprenorphine, butorphanol,
Central Nervous System prescribing guidelines for: nursing mothers; CNS depressants, desmopressin, droperidol,
Depression [5] pediatric patients hypnotics, linezolid, MAO inhibitors, mirtazapine,
Headache [3] Note: Jalyn is tamsulosin and dutasteride. nalbuphine, PEG-interferon, pegvisomant,
Insomnia [4] pentazocine, phenothiazines, sedatives,
Mood changes [3] sibutramine, SNRIs, SSRIs, St John’s wort,
Parkinsonism [2] Mucosal
Xerostomia [4] succinylcholine, thiazide diuretics, tramadol,
Stroke [4] tranquilizers, trazodone, tricyclic antidepressants,
Vertigo (dizziness) [3] Cardiovascular triptans
Neuromuscular/Skeletal Chest pain (4%) Pregnancy category: C
Asthenia (fatigue) [5] Hypotension (6–19%) [3] Important contra-indications noted in the
Bone or joint pain [3] Postural hypotension [3] prescribing guidelines for: the elderly; nursing
Fractures [2] Central Nervous System mothers; pediatric patients
Leg cramps [2] Headache (19–21%) [6] Note: Contra-indicated in patients with impaired
Myalgia/Myopathy [4] Insomnia (<2%) pulmonary function or paralytic ileus. Should not
Gastrointestinal/Hepatic Somnolence (drowsiness) (3–4%) be used in patients currently using or within 14
Hepatic steatosis [2] Vertigo (dizziness) (15–17%) [16] days of using a monoamine oxidase inhibitor.
Hepatotoxicity [10] Neuromuscular/Skeletal Warning: For extended release oral tablets:
Nausea [4] Asthenia (fatigue) (8–9%) [2] ABUSE POTENTIAL, LIFE-THREATENING
Pancreatitis [4] Back pain (7–8%) RESPIRATORY DEPRESSION, ACCIDENTAL
Vomiting [3] EXPOSURE, and INTERACTION WITH
Gastrointestinal/Hepatic ALCOHOL
Respiratory Constipation [2]
Pulmonary embolism [7] Diarrhea (4–6%)
Nausea (3–4%) Mucosal
Endocrine/Metabolic Xerostomia [4]
ALP increased [2] Respiratory
Amenorrhea [8] Cough (3–5%) Central Nervous System
Galactorrhea (<10%) Pharyngitis (5–6%) Headache [4]
Hypercholesterolemia [2] Rhinitis (13–18%) [2] Neurotoxicity [2]
Hypertriglyceridemia [7] Sinusitis (2–4%) Somnolence (drowsiness) [8]
Libido decreased [4] Vertigo (dizziness) (4%) [9]
Endocrine/Metabolic
Weight gain [4] Libido decreased (<2%) Neuromuscular/Skeletal
Genitourinary Asthenia (fatigue) [3]
Genitourinary
Dyspareunia [4] Ejaculatory dysfunction (8–18%) [9] Gastrointestinal/Hepatic
Endometrial cancer [5] Erectile dysfunction [2] Constipation [15]
Ovarian hyperstimulation syndrome [2] Priapism [4] Diarrhea [2]
Sexual dysfunction [2] Urinary retention [3] Gastrointestinal disorder [2]
Vaginal bleeding [4] Nausea (4%) [21]
Vaginal discharge [5] Ocular Vomiting (3%) [14]
Vaginal dryness [5] Floppy iris syndrome [34]
Vision blurred (<2%) Other
Hematologic Adverse effects [4]
Hemolytic uremic syndrome [2] Other
Thrombosis [9] Adverse effects [3]
Infection (9–11%)
Ocular Tooth disorder (<2%) TARTRAZINE
Cataract [9]
Keratopathy [4] Class: Food additive
Macular edema [2] Half-life: N/A
Maculopathy [5] Clinically important, potentially hazardous
Ocular adverse effects [5] interactions with: none known
Ocular toxicity [5] Note: Tartrazine intolerance has been estimated
Retinopathy [5] to affect between 0.01% and 0.1% of the
Vision impaired [3] population. Adverse reactions are most common
in people who are sensitive to aspirin.
TARTRAZINE Over 100 updates per week on www.drugeruptiondata.com
Banned in Austria and Norway. Hematologic

TAZAROTENE Anemia (<2%)
Skin Trade names: Avage (Allergan), Fabior (GSK), Ocular
Anaphylactoid reactions/Anaphylaxis [8] Tazorac (Allergan), Zorac (Allergan) Asthenopia (<2%)
Angioedema [11] Indications: Acne vulgaris, mild to moderate Vision blurred (<2%)
Atopic dermatitis [2] plaque psoriasis involving up to 10% body surface Vision impaired (<2%)
Hypersensitivity [9] area Vitreous floaters (<2%)
Pruritus [2] Half-life: 18 hours Local
Purpura [5] Clinically important, potentially hazardous Infusion-related reactions (<2%)
Urticaria (often related to aspirin interactions with: none known
intolerance) [33] Other
Pregnancy category: X Adverse effects [2]
Vasculitis [3] Important contra-indications noted in the Infection (<2%)
Other prescribing guidelines for: the elderly; nursing
Adverse effects [3] mothers; pediatric patients
Skin
TEDUGLUTIDE
Burning (10–20%) [5] Trade name: Gattex (Hospira)
TASIMELTEON Contact dermatitis (5–10%) Indications: Treatment of short bowel syndrome
Desquamation (5–10%) in adult patients dependent on parenteral support
Trade name: Hetlioz (Vanda) Erythema (10–20%) [5] Class: Glucagon-like peptide-2 (GLP-2) analog
Indications: Non-24-hour sleep-wake disorder Pruritus (10–25%) [11] Half-life: 1–2 hours
Class: Melatonin receptor agonist Psoriasis (5–10%) Clinically important, potentially hazardous
Half-life: 2–3 hours Rash (5–10%) interactions with: none known
Clinically important, potentially hazardous Scaling [2] Pregnancy category: B
interactions with: fluvoxamine, ketoconazole, Stinging (<3%) [2] Important contra-indications noted in the
rifampin Xerosis (<3%) [5] prescribing guidelines for: nursing mothers;
Pregnancy category: C Local pediatric patients
Important contra-indications noted in the Application-site reactions [2]
mothers; pediatric patients Other Skin
Adverse effects [2] Edema [4]
Side effects [2] Hypersensitivity (<10%)
Abnormal dreams (10%) [3] Central Nervous System
Headache (17%) [3] Headache (16%) [6]
Nightmares (10%) [3] TEDIZOLID Sleep disturbances (<10%)
Respiratory Gastrointestinal/Hepatic
Trade name: Sivextro (Cubist) Abdominal distension (14%) [4]
Upper respiratory tract infection (7%) [2] Indications: Acute bacterial skin and skin Abdominal pain (30%) [8]
Endocrine/Metabolic structure infections caused by susceptible bacteria Constipation [3]
ALT increased (10%) [2] Class: Antibiotic, oxazolidinone Flatulence (<10%)
Genitourinary Half-life: 12 hours Gastrointestinal disorder [2]
Urinary tract infection (7%) [3] Clinically important, potentially hazardous Hepatotoxicity [3]
interactions with: none known Nausea (18%) [7]
Pregnancy category: C Vomiting (<10%) [2]
TASONERMIN prescribing guidelines for: nursing mothers; Respiratory
pediatric patients Cough (<10%)
See: www.drugeruptiondata.com/drug/id/1400 Nasopharyngitis [2]
Skin
Dermatitis (<2%) Local
TAVABOROLE Hypersensitivity (<2%) Injection-site erythema [2]
Pruritus (<2%) Injection-site reactions (22%)
Indications: Onychomycosis Urticaria (<2%) Other
Class: Antifungal, oxaborole
Cardiovascular Adverse effects [9]
Half-life: N/A
Clinically important, potentially hazardous Flushing (<2%)
interactions with: none known Hypertension (<2%)
Pregnancy category: C Palpitation (<2%)
Important contra-indications noted in the Tachycardia (<2%)
prescribing guidelines for: nursing mothers; Central Nervous System
pediatric patients Headache (6%) [3]
Hypoesthesia (<2%)
Nails Insomnia (<2%)
Onychocryptosis (3%) Vertigo (dizziness) (2%) [3]
Local Gastrointestinal/Hepatic
Application-site erythema (2%) [2] Diarrhea (4%) [4]
Application-site exfoliation (3%) Nausea (8%) [5]
Vomiting (3%) [4]
Litt’s Drug Eruption & Reaction Manual TELAPREVIR
Nausea (23%) [18] Pruritus (<10%)

TEGAFUR/GIMERACIL/ Vomiting (8%) [13] Rash (<10%) [4]
Red man syndrome [3]
OTERACIL Respiratory
Urticaria [2]
Pharyngitis (<5%)
Synonyms: TS-1; S-1 Pneumonitis [4] Central Nervous System
Trade name: Teysuno (Taiho Pharma) Rhinitis (<5%) Fever (<10%)
Indications: Gastric, colorectal, head and neck Endocrine/Metabolic Gastrointestinal/Hepatic
cancers, non-small cell lung cancer, inoperable or ALT increased (12%) [5] Hepatotoxicity (2%) [2]
recurrent breast cancer, pancreatic cancer Appetite decreased [5] Renal
Class: Antineoplastic AST increased (12%) [3] Nephrotoxicity [2]
Half-life: N/A Hyperbilirubinemia [3]
Clinically important, potentially hazardous Hyponatremia [4] Hematologic
interactions with: capecitabine, flucytosine, Weight loss (<5%) Neutropenia [2]
fluorouracil, other fluoropyrimidine-group Otic
Genitourinary
antineoplastics, phenytoin, uracil/tegafur, warfarin Ototoxicity [2]
Glycosuria (<5%)
Pregnancy category: N/A (Contra-indicated in
Hematuria (<5%) Other
pregnancy)
Important contra-indications noted in the Renal Adverse effects [2]
prescribing guidelines for: the elderly; nursing Nephrotoxicity [2]
mothers; pediatric patients Proteinuria (<5%)
Note: Contra-indicated in patients with severe Hematologic TELAPREVIR
bone marrow depression, hepatic or renal Anemia [26]
impairment. Bleeding (<5%) Trade name: Incivek (Vertex)
Not available in the USA. Bone marrow suppression [2] Indications: Hepatitis C (must only be used in
Febrile neutropenia [12] combination with PEG-interferon alfa and
Skin Hemotoxicity [5] ribavirin)
Leukocytopenia [2] Class: CYP3A4 inhibitor, Direct-acting antiviral,
Dermatitis (<5%)
Leukopenia (87%) [25] Hepatitis C virus NS3/4A protease inhibitor
Desquamation (<5%)
Myelosuppression [6] Half-life: 4–11 hours
Edema (<5%) [3]
Neutropenia (44%) [48] Clinically important, potentially hazardous
Erythema (<5%)
Thrombocytopenia (11%) [18] interactions with: alfuzosin, alprazolam,
Hand–foot syndrome (<5%) [12]
amiodarone, amlodipine, atazanavir, atorvastatin,
Herpes simplex (<5%) Ocular bepridil, bosentan, budesonide, carbamazepine,
Jaundice (<5%) Conjunctivitis (<5%) cisapride, dabigatran, darunavir, desipramine,
Pigmentation (21%) [9] Keratitis (<5%) dexamethasone, digoxin, dihydroergotamine,
Pruritus (<5%) Lacrimation (<5%) diltiazem, efavirenz, ergotamine, escitalopram,
Rash (12%) [6] Ocular adverse effects [2] estradiol, felodipine, flecainide, flibanserin,
Raynaud’s phenomenon (<5%) Ocular pain (<5%) fluticasone propionate, fosamprenavir,
Ulcerations (<5%) Reduced visual acuity (<5%) itraconazole, ketoconazole, lidocaine, lomitapide,
Xerosis (<5%) [2]
Other lovastatin, methylergonovine,
Hair Adverse effects [21] methylprednisolone, midazolam, mifepristone,
Alopecia (<5%) [4] Death [3] nicardipine, nisoldipine, olaparib, palbociclib,
Nails phenobarbital, phenytoin, pimozide, ponatinib,
Nail disorder (<5%) posaconazole, propafenone, quinidine, rifampin,
Paronychia (<5%) [2] TEGASEROD ritonavir, ruxolitinib, salmeterol, sildenafil,
simvastatin, sirolimus, St John’s wort, tacrolimus,
Mucosal
See: www.drugeruptiondata.com/drug/id/936 tadalafil, telithromycin, tenofovir disoproxil,
Mucositis [7]
trazodone, triazolam, vardenafil, venetoclax,
Stomatitis (17%) [9]
verapamil, vorapaxar, voriconazole, warfarin,
Cardiovascular zolpidem
Flushing (<5%) TEICOPLANIN Pregnancy category: X
Hypertension (<5%) Important contra-indications noted in the
Hypotension (<5%) Trade name: Targocid (Sanofi-Aventis) prescribing guidelines for: the elderly; nursing
Indications: Staphylococcal infections mothers; pediatric patients
Class: Antibiotic, glycopeptide Note: Must be used in combination with PEG-
Anorexia (34%) [25]
Half-life: 150 hours interferon alfa and ribavirin (see separate entries).
Fever (<5%) [2]
Clinically important, potentially hazardous Warning: SERIOUS SKIN REACTIONS
Headache (<5%)
interactions with: amikacin, cephaloridine,
Neurotoxicity [4]
colistin, gentamicin, kanamycin, neomycin,
Paresthesias (<5%) Skin
streptomycin, tobramycin, vancomycin
Peripheral neuropathy [3] Dermatitis [2]
Pregnancy category: N/A (Not recommended
Vertigo (dizziness) (<5%) DRESS syndrome [6]
in pregnancy)
Warm feeling (<5%) Exanthems [6]
Neuromuscular/Skeletal prescribing guidelines for: nursing mothers Pruritus (including anal pruritus) (53%) [14]
Arthralgia (<5%) Rash (56%) [38]
Asthenia (fatigue) (22%) [14] Stevens-Johnson syndrome [3]
Skin Toxic epidermal necrolysis [2]
DRESS syndrome [3] Toxicity [2]
Gastrointestinal/Hepatic Erythema (<10%)
Diarrhea (19%) [37] Exanthems [2] Central Nervous System
Hepatotoxicity [6] Hypersensitivity [3] Dysgeusia (taste perversion) (10%)
TELAPREVIR See all our books at www.crcpress.com
Neuromuscular/Skeletal Upper respiratory tract infection (>5%) Gastrointestinal/Hepatic

Asthenia (fatigue) (56%) [4] Endocrine/Metabolic Abdominal distension (>5%)
Gastrointestinal/Hepatic ALT increased (3%) Abdominal pain (>5%)
Anorectal discomfort (11%) Creatine phosphokinase increased [4] Constipation (>5%)
Diarrhea (26%) [2] Flatulence (7%)
Hematologic Nausea (13%) [2]
Hemorrhoids (12%) Neutropenia (2%)
Hepatotoxicity [5] Endocrine/Metabolic
Nausea (39%) [4] ALP increased (<5%)
Vomiting (13%) ALT increased (<5%)
Renal
TELITHROMYCIN Appetite decreased (7%)
Nephrotoxicity [3] AST increased (<5%)
See: www.drugeruptiondata.com/drug/id/1038 GGT increased (9%)
Hematologic
Anemia [36]
Neutropenia [6]
TELMISARTAN TEMAZEPAM
Other Trade name: Micardis (Boehringer Ingelheim) Trade name: Restoril (Mallinckrodt)
Adverse effects [19] Indications: Hypertension Indications: Insomnia, anxiety
Infection [4] Class: Angiotensin II receptor antagonist Class: Benzodiazepine
(blocker), Antihypertensive Half-life: 815 hours
Half-life: 24 hours Clinically important, potentially hazardous
TELAVANCIN interactions with: ramipril
interactions with: amprenavir,
chlorpheniramine, clarithromycin, efavirenz,
Pregnancy category: D (category C in first esomeprazole, imatinib, mianserin, nelfinavir
trimester; category D in second and third Pregnancy category: X
trimesters) Important contra-indications noted in the
Important contra-indications noted in the prescribing guidelines for: the elderly; nursing
TELBIVUDINE prescribing guidelines for: nursing mothers; mothers; pediatric patients
pediatric patients
Trade names: Sebvio (Novartis), Tyzeka Warning: FETAL TOXICITY
(Novartis) Skin
Indications: Hepatitis B (chronic) Dermatitis (<10%)
Class: Nucleoside analog reverse transcriptase
Skin Diaphoresis (>10%)
inhibitor Angioedema [2] Rash (>10%)
Half-life: ~15 hours Peripheral edema [2]
Mucosal
Clinically important, potentially hazardous Cardiovascular Sialopenia (>10%)
interactions with: interferon alfa, PEG- Hypotension [2] Sialorrhea (<10%)
interferon Central Nervous System Xerostomia (2%)
Pregnancy category: B Headache [4]
Important contra-indications noted in the Other
Vertigo (dizziness) [5] Adverse effects [2]
mothers; pediatric patients Neuromuscular/Skeletal
Skin Respiratory TEMOZOLOMIDE
Pruritus (2%) Cough [9]
Rash (4%) Endocrine/Metabolic Trade name: Temodar (MSD)
Hyperkalemia [2] Indications: Anaplastic astrocytoma, newly
Cardiovascular diagnosed glioblastoma multiforme concomitantly
Arrhythmias [2] with radiotherapy and then as maintenance
Central Nervous System treatment
Fever (4%) TELOTRISTAT ETHYL * Class: Alkylating agent, Antineoplastic
Headache (11%) Half-life: 1.8 hours
Insomnia (3%) Trade name: Xermelo (Lexicon) Clinically important, potentially hazardous
Neurotoxicity [2] Indications: Carcinoid syndrome diarrhea in interactions with: clozapine, digoxin, valproic
Vertigo (dizziness) (4%) combination with somatostatin analog (SSA) acid
therapy for adults inadequately controlled by SSA Pregnancy category: D
Neuromuscular/Skeletal therapy
Arthralgia (4%) Important contra-indications noted in the
Class: Tryptophan hydroxylase inhibitor prescribing guidelines for: the elderly; nursing
Asthenia (fatigue) (>5%) [2] Half-life: <1 hour
Back pain (4%) mothers; pediatric patients
Myalgia/Myopathy (3%) [8] interactions with: CYP3A4 substrates
Gastrointestinal/Hepatic Pregnancy category: N/A (No data available) Skin
Abdominal distension (3%) Important contra-indications noted in the Peripheral edema (11%)
Abdominal pain (12%) prescribing guidelines for: nursing mothers; Pruritus (8%)
Diarrhea [2] pediatric patients Rash (8%) [8]
Dyspepsia (3%) Toxicity [3]
Hepatitis (exacerbation) (2%) Central Nervous System Hair
Respiratory Depression (9%) Alopecia [3]
Cough (7%) Fever (7%) Cardiovascular
Flu-like syndrome (7%) Headache (11%) Thromboembolism [2]
Pharyngolaryngeal pain (5%)
Litt’s Drug Eruption & Reaction Manual TENOFOVIR ALAFENAMIDE
Central Nervous System Rash (47%) [14] Other

Anorexia [3] Toxicity [3] Adverse effects [9]
Fever [2] Xerosis (11%) Death [2]
Headache [3] Nails Infection (20%) [5]
Paresthesias (9%) Nail disorder (14%)
Neuromuscular/Skeletal Paronychia [2]
Asthenia (fatigue) [14] Mucosal TENECTEPLASE
Myalgia/Myopathy (5%) Mucositis (30%) [12]
Gastrointestinal/Hepatic Oral mucositis [2] See: www.drugeruptiondata.com/drug/id/812
Constipation [2] Stomatitis [16]
Diarrhea [8] Cardiovascular
Hepatotoxicity [6] Chest pain (16%) TENIPOSIDE
Nausea [9] Hypertension (7%) [3]
Vomiting [4] See: www.drugeruptiondata.com/drug/id/1204
Endocrine/Metabolic Anorexia (30%) [3]
Mastodynia (6%) Chills (8%)
Hematologic Depression (4%) TENOFOVIR
Anemia [3] Dysgeusia (taste perversion) (20%) [2]
Febrile neutropenia [2] Fever (24%)
ALAFENAMIDE
Hemotoxicity [5] Headache (15%)
Trade names: Descovy (Gilead), Vemlidy
Leukopenia [6] Insomnia (12%)
(Gilead)
Lymphocytopenia [4] Neurotoxicity [2]
Indications: Hepatitis B
Lymphopenia [4] Pain (28%)
Class: Antiviral, Hepatitis B virus necleoside
Myelosuppression [3] Neuromuscular/Skeletal analog reverse transcriptase inhibitor
Neutropenia [10] Arthralgia (18%) Half-life: <1 hour
Thrombocytopenia [11] Asthenia (fatigue) (30%) [20] Clinically important, potentially hazardous
Other Back pain (20%) interactions with: carbamazepine,
Death [7] Myalgia/Myopathy (8%) oxcarbazepine, phenobarbital, phenytoin,
Infection [5] Gastrointestinal/Hepatic rifabutin, rifampin, rifapentine, St John’s wort
Abdominal pain (21%) Pregnancy category: N/A (No data available)
Diarrhea [7] Important contra-indications noted in the
TEMSIROLIMUS Nausea [7] prescribing guidelines for: nursing mothers;
pediatric patients
Vomiting [2]
Trade name: Torisel (Wyeth) Note: Descovy is tenofovir alafenamide and
Respiratory emtricitabine. See also separate profile for
Indications: Renal cell carcinoma, other cancers Cough (26%) [3]
Class: Analog of sirolimus, Antineoplastic, mTOR tenofovir alafenamide in combination with
Dyspnea [7] cobicistat, elvitegravir and emtricitabine.
inhibitor Pharyngitis (12%)
Half-life: 17 hours Warning: LACTIC ACIDOSIS/SEVERE
Pneumonia [2] HEPATOMEGALY WITH STEATOSIS and POST
Clinically important, potentially hazardous Pneumonitis (36%) [11]
interactions with: ACE inhibitors, atazanavir, TREATMENT SEVERE ACUTE
Rhinitis (10%) EXACERBATION OF HEPATITIS B
BCG vaccine, benazepril, captopril, Upper respiratory tract infection (7%)
carbamazepine, clarithromycin, clozapine,
conivaptan, cyclosporine, darunavir, dasatinib, Endocrine/Metabolic Central Nervous System
denosumab, dexamethasone, digoxin, enalapril, ALT increased [4] Headache (9%) [3]
fluconazole, fosinopril, grapefruit juice, AST increased [2]
Dehydration [2] Neuromuscular/Skeletal
hypoglycemic agents, indinavir, itraconazole, Asthenia (fatigue) (6%)
ketoconazole, leflunomide, lisinopril, live and Hypercholesterolemia [4]
Hyperglycemia [14] Back pain (5%)
inactive vaccines, macolide antibiotics,
natalizumab, nefazodone, nelfinavir, P- Hyperlipidemia [2] Gastrointestinal/Hepatic
glycoprotein inhibitors, phenobarbital, phenytoin, Hypertriglyceridemia [5] Abdominal pain (7%)
pimecrolimus, posaconazole, protease inhibitors, Hypokalemia [3] Nausea (5%)
quinapril, ramipril, rifabutin, rifampin, rifapentine, Hypophosphatemia [4] Respiratory
ritonavir, saquinavir, St John’s wort, sunitinib, Serum creatinine increased [2]
Cough (6%)
tacrolimus, telithromycin, tipranavir, trastuzumab, Genitourinary Nasopharyngitis [2]
voriconazole Urinary tract infection (15%) Upper respiratory tract infection [2]
Pregnancy category: D Hematologic Endocrine/Metabolic
Important contra-indications noted in the Anemia [10] ALT increased (8%)
prescribing guidelines for: the elderly; nursing Febrile neutropenia [3] AST increased (3%)
mothers; pediatric patients Hemorrhage [2] Creatine phosphokinase increased (3%)
Note: Contra-indicated in patients with bilirubin Hemotoxicity [2] Hyperamylasemia (3%)
>1.5xULN. Immunosupression [2] Hypercholesterolemia (4%)
Leukopenia [4] Genitourinary
Skin Lymphopenia [4]
Glycosuria (5%)
Acneform eruption (10%) [4] Neutropenia [5]
Edema [2] Thrombocytopenia [16] Other
Exanthems [3] Adverse effects [2]
Ocular
Hypersensitivity (9%) [3] Conjunctivitis (7%)
Pruritus (19%) [3]
TENOFOVIR DISOPROXIL Over 100 updates per week on www.drugeruptiondata.com
Hepatotoxicity [3]
TENOFOVIR Nausea (8%) [10] TERBINAFINE
Pancreatitis [5]
DISOPROXIL Vomiting (4–5%) [5] Trade name: Lamisil (Novartis)
Indications: Fungal infections of the skin and nails
Trade names: Atripla (Gilead), Complera Respiratory Class: Antifungal
(Gilead), Truvada (Gilead), Viread (Gilead) Nasopharyngitis [3] Half-life: ~36 hours
Indications: HIV infection in combination with at Pneumonia (2–5%) Clinically important, potentially hazardous
least two other antiretroviral agents Upper respiratory tract infection [2] interactions with: amitriptyline, amphotericin B,
Class: Antiretroviral, Nucleoside analog reverse Endocrine/Metabolic atomoxetine, caffeine, carbamazepine,
transcriptase inhibitor Acidosis [3] cimetidine, codeine, conivaptan, cyclosporine,
Half-life: 12–18 hours ALT increased [3] CYP2D6 substrates, desipramine, estrogens,
Clinically important, potentially hazardous Creatine phosphokinase increased [3] fesoterodine, fluconazole, nebivolol,
interactions with: acyclovir, adefovir, atazanavir, Hypokalemia [2] progestogens, rifampin, rifapentine, saxagliptin,
cidofovir, cobicistat/elvitegravir/emtricitabine/ Hypophosphatemia [3] tamoxifen, tamsulosin, tetrabenazine,
tenofovir disoproxil, darunavir, didanosine, Weight loss (2%) thioridazine, tramadol, tricyclic antidepressants
ganciclovir, high-fat foods, indinavir, ledipasvir & Pregnancy category: B
Renal
sofosbuvir, lopinavir, protease inhibitors, ritonavir, Important contra-indications noted in the
Fanconi syndrome [25]
telaprevir, tipranavir, trospium, valacyclovir, prescribing guidelines for: nursing mothers;
Nephrotoxicity [41]
valganciclovir pediatric patients
Proteinuria [4]
Renal failure [10]
Renal tubular necrosis [2] Skin
pediatric patients Other AGEP [24]
Note: Atripla is tenofovir disoproxil, efavirenz Adverse effects [11] Baboon syndrome (SDRIFE) [2]
and emtricitabine; Complera is tenofovir
Dermatitis (<10%)
disoproxil, emtricitabine and rilpivirine; Truvada is
Eczema [2]
tenofovir disoproxil and emtricitabine. See also
separate profile for tenofovir disoproxil in
TENOXICAM Erythroderma [2]
combination with cobicistat, elvitegravir and
Exanthems [5]
See: www.drugeruptiondata.com/drug/id/1346 Fixed eruption [3]
emtricitabine.
Warning: LACTIC ACIDOSIS/SEVERE
HEPATOMEGALY WITH STEATOSIS and POST
Lichenoid eruption [2]
TREATMENT EXACERBATION OF HEPATITIS TERAZOSIN Lupus erythematosus [30]
Pityriasis rosea [2]
Trade name: Hytrin (AbbVie) Pruritus (3%) [6]
Skin Indications: Hypertension, benign prostatic Psoriasis [14]
Diaphoresis (3%) hypertrophy Pustules [3]
Lichenoid eruption [2] Class: Adrenergic alpha-receptor antagonist Rash (6%) [3]
Rash (5–18%) [4] Half-life: 12 hours Stevens-Johnson syndrome [2]
Stevens-Johnson syndrome [2] Clinically important, potentially hazardous Toxic epidermal necrolysis [3]
Cardiovascular interactions with: vardenafil Urticaria [7]
Chest pain (3%) Pregnancy category: C Hair
Central Nervous System Alopecia (<10%)
Abnormal dreams [3] Skin Nails
Anorexia (3%) Edema (<10%) Onychocryptosis [2]
Anxiety (6%) [2] Lichenoid eruption [2]
Depression (4–11%) Peripheral edema (6%) Central Nervous System
Fever (2–8%) Ageusia (taste loss) [17]
Mucosal Dysgeusia (taste perversion) (3%) [8]
Headache (5–14%) [10] Xerostomia (<10%)
Insomnia (3–5%) [2] Headache (13%)
Neurotoxicity (3%) [6]
Cardiovascular Gastrointestinal/Hepatic
Pain (7–13%) Postural hypotension [2] Abdominal pain (2%)
Peripheral neuropathy (<3%) Central Nervous System Diarrhea (6%)
Somnolence (drowsiness) [2] Paresthesias (3%) Dyspepsia (4%)
Vertigo (dizziness) (<3%) [4] Vertigo (dizziness) [3] Flatulence (2%)
Neuromuscular/Skeletal Genitourinary Hepatotoxicity [11]
Arthralgia (5%) Priapism [2] Nausea (3%)
Asthenia (fatigue) (6–7%) [6] Ocular Other
Back pain (3–9%) Floppy iris syndrome [2] Adverse effects [3]
Bone or joint pain [4] Allergic reactions (<10%)
Fractures [2] Side effects (3%)
Myalgia/Myopathy (3%) [2]
Osteomalacia [5]
Abdominal pain (4–7%) [2]
Diarrhea (11%) [7]
Dyspepsia (3–4%)
Flatulence (3%)
Hepatic failure [2]
Litt’s Drug Eruption & Reaction Manual TERIPARATIDE
Skin
TERBUTALINE Acneform eruption (<3%) TERIPARATIDE
Burning (2–3%)
Trade names: Brethine (aaiPharma), Bricanyl Herpes (oral) (2–4%) Trade name: Forteo (Lilly)
(AstraZeneca) Pruritus (3–4%) Indications: Osteoporosis in postmenopausal
Indications: Bronchospasm women and men at increased risk of fractures
Class: Beta-2 adrenergic agonist, Bronchodilator, Hair Class: Parathyroid hormone analog
Tocolytic Alopecia (10–13%) [14] Half-life: 1 hour
Half-life: 1116 hours Cardiovascular Clinically important, potentially hazardous
Clinically important, potentially hazardous Hypertension (4%) [3] interactions with: alcohol, digoxin
interactions with: alpha blockers, atomoxetine, Palpitation (2–3%) Pregnancy category: C
beta blockers, betahistine, cannabinoids, Central Nervous System Important contra-indications noted in the
epinephrine, insulin aspart, insulin degludec, Anxiety (3–4%) prescribing guidelines for: nursing mothers;
insulin detemir, insulin glargine, insulin glulisine, Carpal tunnel syndrome (<3%) pediatric patients
iobenguane, loop diuretics, MAO inhibitors, Headache (19–22%) [4] Warning: POTENTIAL RISK OF
propranolol, sotalol, sympathomimetics, tricyclic Paresthesias (9–10%) [3] OSTEOSARCOMA
antidepressants, yohimbine Peripheral neuropathy (<2%) [2]
Asthenia (fatigue) [2] Diaphoresis (2%)
prescribing guidelines for: nursing mothers; Herpes zoster (3%)
pediatric patients Back pain (<3%) [2]
Bone or joint pain (4–5%) Rash (5%)
Warning: PROLONGED TOCOLYSIS
Myalgia/Myopathy (3–4%) Cardiovascular
Gastrointestinal/Hepatic Angina (3%)
Skin Hypertension (7%)
Diaphoresis (<10%) Abdominal distension (<2%)
Abdominal pain (5–6%) Central Nervous System
Mucosal Diarrhea (15–18%) [11] Anxiety (4%)
Xerostomia (<10%) Gastroenteritis (2–4%) Depression (4%)
Cardiovascular Hepatotoxicity [4] Dysgeusia (taste perversion) (<2%)
Arrhythmias [2] Nausea (9–14%) [9] Headache (8%) [8]
Central Nervous System Respiratory Insomnia (4–5%)
Dysgeusia (taste perversion) (<10%) Bronchitis (5–8%) Pain (21%)
Tremor [2] Influenza (9–12%) [2] Paresthesias (<2%)
Nasopharyngitis [2] Syncope (3%)
Gastrointestinal/Hepatic Vertigo (dizziness) (4–8%) [7]
Nausea [2] Sinusitis (4–6%)
Upper respiratory tract infection (9%) Neuromuscular/Skeletal
Other Arthralgia (10%) [3]
Side effects [2] Endocrine/Metabolic
ALT increased (12–14%) [11] Asthenia (fatigue) (9%)
AST increased (2–3%) Bone tumor [2]
GGT increased (3–5%) Leg cramps (3%) [4]
TERCONAZOLE Hypophosphatemia (mild) (18%) Myalgia/Myopathy [2]
Weight loss (2–3%) Neck pain (3%)
See: www.drugeruptiondata.com/drug/id/679 Pain in extremities [3]
Genitourinary
Cystitis (2–4%) Gastrointestinal/Hepatic
Constipation (5%)
TERFENADINE Renal
Renal failure [2]
Diarrhea (5%)
Dyspepsia (5%)
See: www.drugeruptiondata.com/drug/id/680 Hematologic Gastritis (2–7%)
Immunosupression (10–15%) Nausea (9–14%) [8]
Leukopenia (<2%) [2] Vomiting (3%)
TERIFLUNOMIDE Lymphopenia [2]
Neutropenia (2–4%) [4]
Respiratory
Cough (6%)
Trade name: Aubagio (Sanofi-Aventis) Ocular Dyspnea (4–6%)
Indications: Relapsing forms of multiple sclerosis Conjunctivitis (<3%) Pharyngitis (6%)
Class: Pyrimidine synthesis inhibitor Vision blurred (3%) Pneumonia (4–6%)
Half-life: N/A
Other Rhinitis (10%)
Clinically important, potentially hazardous Endocrine/Metabolic
Adverse effects [4]
interactions with: alosetron, caffeine, Hypercalcemia [6]
Allergic reactions (2–3%)
duloxetine, ethinylestradiol, leflunomide, live
Infection [5] Local
vaccines, oral contraceptives, paclitaxel,
Side effects [2] Injection-site pain (<2%)
pioglitazone, repaglinide, rosiglitazone,
Toothache (4%)
theophylline, tizanidine, warfarin Other
Pregnancy category: X Adverse effects [4]
Important contra-indications noted in the Tooth disorder (2%)
Warning: HEPATOTOXICITY and RISK OF
TERATOGENICITY
TERLIPRESSIN See all our books at www.crcpress.com
Edema (<10%) Central Nervous System

TERLIPRESSIN Rash (2%) Dysgeusia (taste perversion) (8%)
Hair Headache (10%)
Trade names: Glypressin (IS Pharma), Hypoesthesia (intranasal and pharyngeal)
Terlipressin (Ferring) (Bissendorf Peptide) Alopecia [3]
Hirsutism (<10%) [12] (10%)
Indications: Esophageal variceal hemorrhage Sensory disturbances (2%)
Class: Vasopressin agonist Cardiovascular Vertigo (dizziness) (3%)
Half-life: 50–70 minutes Cardiotoxicity [2]
Clinically important, potentially hazardous Flushing (<10%) Ocular
interactions with: none known Myocardial infarction [3] Lacrimation (13%)
Pregnancy category: N/A (Contra-indicated in Endocrine/Metabolic Other
pregnancy) Gynecomastia [2] Sneezing (4%)
Mastodynia (>10%)
Skin Genitourinary
Gangrene [2] Priapism (>10%) [10] TETRACYCLINE
Necrosis [12]
Hematologic Trade names: Helidac (Prometheus), Sumycin
Cardiovascular Thrombosis [2]
Myocardial infarction [3] (Par)
QT prolongation [2] Local Indications: Various infections caused by
Torsades de pointes [2] Application-site bullae (12%) susceptible organisms
Application-site burning (3%) Class: Antibiotic, tetracycline
Central Nervous System Application-site erythema (7%) Half-life: 611 hours
Seizures [3] Application-site induration (3%) Clinically important, potentially hazardous
Neuromuscular/Skeletal Application-site pruritus (37%) interactions with: ACE inhibitors, acitretin,
Rhabdomyolysis [3] Application-site vesicles (6%) aluminum, amoxicillin, ampicillin, antacids,
Endocrine/Metabolic Injection-site pain [2] atovaquone, atovaquone/proguanil, bacampicillin,
Hyponatremia [8] Other betamethasone, bismuth, bromelain, calcium
Adverse effects [3] salts, carbenicillin, cholestyramine, cloxacillin,
Other colestipol, corticosteroids, coumarins, dairy
Adverse effects [2] products, dicloxacillin, didanosine, digoxin,
ergotamine, food, gliclazide, isotretinoin, kaolin,
TETRABENAZINE methicillin, methotrexate, methoxyflurane,
TESAMORELIN See: www.drugeruptiondata.com/drug/id/1301
methysergide, mezlocillin, nafcillin, oral iron, oral
typhoid vaccine, oxacillin, penicillins, phenindione,
See: www.drugeruptiondata.com/drug/id/2155 piperacillin, quinapril, retinoids, rocuronium,
sodium picosulfate, strontium ranelate, sucralfate,
TETRACAINE & sulfonylureas, ticarcillin, tripotassium
dicitratobismuthate, vitamin A, zinc
TESTOLACTONE OXYMETAZOLINE * Pregnancy category: D
See: www.drugeruptiondata.com/drug/id/1172 Trade name: Kovanaze (St Renatus)
Skin
Indications: Regional anesthesia in restorative
Acneform eruption [2]
dentistry
Angioedema [2]
TESTOSTERONE Class: Alpha adrenoceptor agonist
Candidiasis [2]
(oxymetazoline), Anesthetic, local (tetracaine)
Trade names: Androderm (Actavis), AndroGel Erythema multiforme [7]
Half-life: <2 hours
(AbbVie), Delatestryl (Endo), Fortesta (Endo), Exanthems [3]
Natesto (Endo), Testim (Auxilium) Exfoliative dermatitis [2]
interactions with: beta blockers, MAO
Indications: Androgen replacement, Fixed eruption (15%) [43]
inhibitors, other intranasal products, tricyclic
hypogonadism, postpartum breast pain Hypersensitivity [2]
antidepressants
Class: Androgen Jarisch–Herxheimer reaction [3]
Half-life: 10100 minutes Lichenoid eruption [3]
to inform drug-associated risk)
Clinically important, potentially hazardous Lupus erythematosus [6]
interactions with: acarbose, anisindione, Photosensitivity (<10%) [12]
anticoagulants, cyclosporine, dicumarol, Phototoxicity [4]
metformin, saxagliptin, sitagliptin, warfarin Pigmentation [4]
Note: For intranasal use only. See separate entry
Pregnancy category: N/A (Contra-indicated in Psoriasis (exacerbation) [2]
for oxymetazoline as topical formulation.
pregnancy) Stevens-Johnson syndrome [4]
Important contra-indications noted in the Toxic epidermal necrolysis [13]
Mucosal Urticaria [5]
Epistaxis (nosebleed) (2%)
pediatric patients Nails
Mucosal ulceration (2–3%)
Note: Contra-indicated in men with carcinoma of Onycholysis [5]
Nasal congestion (32%) [3]
the breast or known or suspected carcinoma of Photo-onycholysis [8]
Nasal discomfort (26%)
the prostate. Central Nervous System
Nasal dryness (2%)
Warning: SECONDARY EXPOSURE TO Pseudotumor cerebri [6]
Oropharyngeal pain (14%)
TESTOSTERONE
Rhinorrhea (52%) [3] Gastrointestinal/Hepatic
Cardiovascular Diarrhea [2]
Skin Blood pressure variations (3–5%) Hepatotoxicity [2]
Acneform eruption (>10%) [20] Bradycardia (3%) Pancreatitis [3]
Carcinoma [2] Hypertension (3%)
Dermatitis (4%) [2]
Litt’s Drug Eruption & Reaction Manual THIOGUANINE
Genitourinary Mucosal
Vaginitis [3] Oral candidiasis (4–11%) THALLIUM
Other Xerostomia (8%) [9]
Indications: For diagnostic use in myocardial
Adverse effects [4] Cardiovascular perfusion imaging
Tooth pigmentation (commonly in under 8- Bradycardia [5] Class: Radioactive element
year-olds) (>10%) [12] Cardiotoxicity [2] Half-life: 73.1 hours
Hypotension (16%) Clinically important, potentially hazardous
Thromboembolism [2] interactions with: none known
TETRAZEPAM Venous thromboembolism [5] Pregnancy category: C
See: www.drugeruptiondata.com/drug/id/2015 Agitation (9–26%) Hair
Fever (19–23%) [2] Alopecia [11]
Hyperesthesia [2]
Nails
THALIDOMIDE Insomnia (9%)
Neurotoxicity (22%) [24] Leukonychia (Mees’ lines) [2]
Trade name: Thalomid (Celgene) Paresthesias (6–16%) [8] Cardiovascular
Indications: Graft-versus-host reactions, Parkinsonism [2] Tachycardia [3]
recalcitrant aphthous stomatitis Peripheral neuropathy [26] Central Nervous System
Class: Immunosuppressant, TNF modulator Somnolence (drowsiness) (36%) [13] Encephalopathy [5]
Half-life: 5–7 hours Tremor (4–26%) [6] Peripheral neuropathy [5]
Clinically important, potentially hazardous Vertigo (dizziness) (4–20%) [16]
interactions with: alcohol, amiodarone, Neuromuscular/Skeletal Abdominal pain [5]
antihistamines, antipsychotics, bortezomib, Arthralgia (13%)
calcium channel blockers, carbamazepine, Asthenia (fatigue) (79%) [16] Other
cimetidine, cisplatin, CNS depressants, digoxin, Myalgia/Myopathy (7%) Death [2]
disulfiram, docetaxel, famotidine, griseofulvin, Gastrointestinal/Hepatic
lithium, metronidazole, modafinil, opioids, Abdominal pain (3%)
paclitaxel, penicillins, phenytoin, rifabutin, Constipation [13] THIABENDAZOLE
rifampin, St John’s wort, succinylcholine, Diarrhea (4–19%)
vincristine Flatulence (8%) Synonym: tiabendazole
Pregnancy category: X Hepatotoxicity [4] Indications: Various infections caused by
Important contra-indications noted in the Pancreatitis [2] susceptible helminths
prescribing guidelines for: nursing mothers; Class: Anthelmintic, Antibiotic, imidazole
pediatric patients Respiratory Half-life: 1.2 hours
Note: Thalidomide is a potent teratogen, an Dyspnea (42%) Clinically important, potentially hazardous
agent that causes congenital malformations and Pharyngitis (4–8%) interactions with: none known
developmental abnormalities if introduced during Pneumonia [2] Pregnancy category: C
gestation. Some of these teratogenic side effects Rhinitis (4%)
of thalidomide include fetal limb growth Sinusitis (3–8%)
Skin
retardation (arms, legs, hands, feet), ingrown Endocrine/Metabolic Dermatitis [3]
genitalia, absence of lung, partial/total loss of Amenorrhea [6] Erythema multiforme [3]
hearing or sight, malformed digestive tract, heart, Gynecomastia [2] Exanthems (>5%) [4]
kidney, and stillborn infant. Weight gain (22%) Fixed eruption [2]
Warning: FETAL RISK AND VENOUS Weight loss (23%) Rash (<10%)
THROMBOEMBOLIC EVENTS
Genitourinary Sjögren’s syndrome [3]
Erectile dysfunction [2] Stevens-Johnson syndrome (<10%)
Skin Impotence (38%) Toxic epidermal necrolysis [2]
Bullous dermatitis (5%) Leukorrhea (17–35%) Urticaria (<5%)
Dermatitis [2] Hematologic Central Nervous System
Diaphoresis (13%) Anemia (6–13%) [4] Vertigo (dizziness) [3]
Edema (57%) [11] Neutropenia (31%) [9]
Erythema [2] Gastrointestinal/Hepatic
Thrombocytopenia [6] Abdominal pain [2]
Erythema nodosum [2] Thrombosis [13]
Erythroderma [2] Nausea [2]
Exanthems [2] Other
Exfoliative dermatitis [4] Adverse effects [8]
Facial erythema (<5%) [2] Death [2] THIAMINE
Hypersensitivity [3] Infection (6–8%) [6]
Peripheral edema (3–8%) [4] Teratogenicity [6] See: www.drugeruptiondata.com/drug/id/686
Pruritus (3–8%) [3] Toothache (4%)
Psoriasis [2]
Purpura [2]
Rash (1150%) [24]
THIMEROSAL
Urticaria (3%) [2]
Vasculitis [2]
Xerosis (21%) [5] THIOGUANINE
THIOPENTAL Over 100 updates per week on www.drugeruptiondata.com
Tremor (9–21%) [7] Bradycardia [2]

THIOPENTAL Vertigo (dizziness) (27–31%) [22] Chest pain (3–4%)
Neuromuscular/Skeletal Hypertension (4%)
See: www.drugeruptiondata.com/drug/id/688 Hypotension (3%)
Ataxia (5–9%) Ventricular arrhythmia [7]
Dystonia [5] Central Nervous System
THIORIDAZINE Myalgia/Myopathy (2–5%) Headache (7%)
Gastrointestinal/Hepatic Vertigo (dizziness) (5%)
Abdominal pain (5–7%) Neuromuscular/Skeletal
Diarrhea (2–10%) Asthenia (fatigue) (3%)
Nausea (11%) [7] Back pain (4%)
THIOTEPA Vomiting (7%) Rhabdomyolysis [2]
See: www.drugeruptiondata.com/drug/id/690 Respiratory Gastrointestinal/Hepatic
Cough (4%) Diarrhea (4%)
Flu-like syndrome (6–9%) Nausea (4%)
Pharyngitis (7–8%) Respiratory
THIOTHIXENE Endocrine/Metabolic Cough (5%)
See: www.drugeruptiondata.com/drug/id/691 Appetite increased (2%) Dyspnea (14%) [19]
Genitourinary Pneumonitis [2]
Urinary tract infection (<5%) Hematologic
THYROTROPIN ALFA Ocular Bleeding (12%) [11]
Amblyopia (4–9%) Other
See: www.drugeruptiondata.com/drug/id/1357 Nystagmus (2%) Adverse effects [2]
Other
Adverse effects [6]
TIAGABINE Infection (10–19%) [3] TICARCILLIN
Trade name: Gabitril (Cephalon) See: www.drugeruptiondata.com/drug/id/693
Indications: Partial seizures
Class: Anticonvulsant, Mood stabilizer
TIANEPTINE
Half-life: 79 hours
See: www.drugeruptiondata.com/drug/id/2065 TICLOPIDINE
interactions with: alcohol, antipsychotics, See: www.drugeruptiondata.com/drug/id/694
carbamazepine, chloroquine, conivaptan,
CYP3A4 inhibitors and inducers, dasatinib, TIBOLONE
deferasirox, droperidol, hydroxychloroquine,
ketorolac, levomepromazine, MAO inhibitors, See: www.drugeruptiondata.com/drug/id/1310 TIGECYCLINE
mefloquine, orlistat, phenobarbital, phenytoin,
SSRIs, St John’s wort, tricyclic antidepressants See: www.drugeruptiondata.com/drug/id/1078
Pregnancy category: C TICAGRELOR
prescribing guidelines for: the elderly; nursing Trade name: Brilinta (AstraZeneca) TILUDRONATE
mothers; pediatric patients Indications: Thrombotic cardiovascular events
Class: Antiplatelet, Antiplatelet, cyclopentyl See: www.drugeruptiondata.com/drug/id/1203
Skin triazolo-pyrimidine (CPTP)
Ecchymoses (<6%) Half-life: 7 hours
Pruritus (2%) Clinically important, potentially hazardous
interactions with: atazanavir, carbamazepine,
TIMOLOL
Rash (5%) [2]
clarithromycin, dexamethasone, digoxin, See: www.drugeruptiondata.com/drug/id/695
Cardiovascular efavirenz, indinavir, itraconazole, ketoconazole,
Vasodilation (2%) lovastatin, nefazodone, nelfinavir, phenobarbital,
Central Nervous System phenytoin, rifampin, ritonavir, saquinavir,
Confusion (5%) simvastatin, telithromycin, venetoclax, TINIDAZOLE
Depression (<7%) [4] voriconazole
Emotional lability (3%) Pregnancy category: C See: www.drugeruptiondata.com/drug/id/1051
Gait instability (3–5%) Important contra-indications noted in the
Headache [8] prescribing guidelines for: nursing mothers;
Hostility (2–5%) pediatric patients TINZAPARIN
Impaired concentration (6–14%) [2] Note: Maintenance doses of aspirin above 100
Insomnia (5–6%) mg reduce the effectiveness of ticagrelor and Trade name: Innohep (Leo Pharma)
Nervousness (10–14%) [10] should be avoided. Contra-indicated in patients Indications: Acute symptomatic deep vein
Pain (2–7%) with a history of intracranial hemorrhage, or thrombosis
Paresthesias (4%) active pathological bleeding, and in patients with Class: Anticoagulant, Heparin, low molecular
Seizures [4] severe hepatic impairment. weight
Somnolence (drowsiness) (18–21%) [9] Warning: BLEEDING RISK Half-life: 34 hours
Speech disorder (4%) Clinically important, potentially hazardous
Status epilepticus (non-convulsive) [17] Cardiovascular interactions with: aliskiren, angiotensin II
Syncope [2] Atrial fibrillation (4%) recepton antagonists, aspirin, butabarbital,
Litt’s Drug Eruption & Reaction Manual TIPRANAVIR
clopidogrel, collagenase, dasatinib, dextran, Pregnancy category: C Death [7]

diclofenac, dipyridamole, drotrecogin alfa, Important contra-indications noted in the Infection (4%)
glyceryl trinitrate, ibritumomab, iloprost, prescribing guidelines for: nursing mothers;
ketorolac, NSAIDs, oral anticoagulants, pentosan, pediatric patients
pentoxifylline, platelet inhibitors, prostacyclin
analogues, salicylates, sulfinpyrazone,
Note: Stiolto Respimat is tiotropium and
olodaterol.
TIPRANAVIR
throbolytics, ticlopidine, tositumomab & iodine131 Trade name: Aptivus (Boehringer Ingelheim)
Pregnancy category: B Skin Indications: Antiretroviral treatment of HIV-1
Important contra-indications noted in the Candidiasis (4%) Class: HIV-1 protease inhibitor, Sulfonamide
prescribing guidelines for: the elderly; nursing Edema (5%) Half-life: 4.86.0 hours
mothers; pediatric patients Herpes zoster (<3%) Clinically important, potentially hazardous
Warning: SPINAL / EPIDURAL HEMATOMAS Rash (4%) interactions with: abacavir, alcohol, alfuzosin,
Mucosal alprazolam, amiodarone, antacids, antifungals,
Skin Epistaxis (nosebleed) (4%) apixaban, artemether/lumefantrine, atazanavir,
Bullous dermatitis (<10%) Oral candidiasis [2] atomoxetine, atorvastatin, bepridil, bosentan,
Pruritus (<10%) Stomatitis (<3%) buprenorphine, calcium channel blockers,
Mucosal Xerostomia (1016%) [22] carbamazepine, cisapride, clarithromycin,
Epistaxis (nosebleed) (2%) codeine, conivaptan, copanlisib, corticosteroids,
Cardiovascular cyclosporine, CYP2D6 substrates, CYP3A4
Cardiovascular Angina (<3%) inducers, dabigatran, darifenacin, deferasirox,
Chest pain (2%) Cardiotoxicity [2] delavirdine, didanosine, digoxin,
Central Nervous System Chest pain (7%) [2] dihydroergotamine, disulfiram, efavirenz, elbasvir
Fever (2%) Hypertension [2] & grazoprevir, eluxadoline, enfuvirtide,
Headache (2%) Central Nervous System eplerenone, ergotamine, esomeprazole, estradiol,
Pain (2%) Depression (<3%) estrogens, etravirine, fesoterodine, flecainide,
Neuromuscular/Skeletal Headache [6] fluconazole, fosamprenavir, fusidic acid, garlic,
Paresthesias (<3%) HMG-CoA reductase inhibitors, lopinavir,
Back pain (2%)
Vertigo (dizziness) [2] lovastatin, meperidine, methadone, metoprolol,
Respiratory metronidazole, midazolam, midostaurin,
Pulmonary embolism (2%) Neuromuscular/Skeletal
nebivolol, nefazodone, neratinib, omeprazole, P-
Arthralgia (>3%)
Endocrine/Metabolic glycoprotein substrates, pantoprazole,
Back pain [4]
ALT increased (13%) phenobarbital, phenytoin, pimozide,
Bone or joint pain (<3%)
AST increased (9%) propafenone, protease inhibitors, proton pump
Leg pain (<3%)
inhibitors, quetiapine, quinidine, quinine,
Genitourinary Myalgia/Myopathy (4%)
raltegravir, ranolazine, rifabutin, rifampin,
Urinary tract infection (4%) Gastrointestinal/Hepatic rilpivirine, rivaroxaban, rosuvastatin, salmeterol,
Hematologic Abdominal pain (5%) saquinavir, sildenafil, simeprevir, simvastatin,
Bleeding [4] Constipation (4%) [2] sirolimus, sofosbuvir, sofosbuvir/velpatasvir/
Hemorrhage (2%) Diarrhea [3] voxilaprevir, St John’s wort, tacrolimus,
Local Dyspepsia (6%) tamoxifen, telithromycin, temsirolimus, tenofovir
Injection-site hematoma (16%) Gastroesophageal reflux (<3%) disoproxil, tetrabenazine, theophylline,
Vomiting (4%) thioridazine, tramadol, trazodone, triazolam,
Respiratory tricyclic antidepressants, valproic acid, vardenafil,
Asthma [4] vitamin E, zidovudine
TIOPRONIN Bronchitis [4] Pregnancy category: C
COPD (exacerbation) [5] Important contra-indications noted in the
Cough (>3%) [8] prescribing guidelines for: the elderly; nursing
Dysphonia (<3%) mothers; pediatric patients
Dyspnea [4] Note: Tipranavir is a sulfonamide and can be
TIOTROPIUM Flu-like syndrome (>3%) absorbed systemically. Sulfonamides can produce
Influenza [3] severe, possibly fatal, reactions such as toxic
Trade names: Spiriva (Boehringer Ingelheim), Laryngitis (<3%) epidermal necrolysis and Stevens-Johnson
Stiolto Respimat (Boehringer Ingelheim) Nasopharyngitis [11] syndrome.
Indications: Bronchospasm (associated with Pharyngitis (9%) Tipranavir is co-administered with ritonavir.
COPD) Pneumonia [3] Contra-indicated in patients with moderate or
Class: Anticholinergic, Muscarinic antagonist Rhinitis (6%) [3] severe (Child-Pugh Class B or C) hepatic
Half-life: 56 days Sinusitis (11%) impairment.
Clinically important, potentially hazardous Upper respiratory tract infection (41%) [4] Warning: HEPATOTOXICITY and
interactions with: acetylcholinesterase INTRACRANIAL HEMORRHAGE
inhibitors, anticholinergics, antihistamines, Endocrine/Metabolic
botulinum toxin (A & B), cannabinoids, Hypercholesterolemia (<3%)
Hyperglycemia (<3%) Skin
conivaptan, disopyramide, domperidone,
Exanthems (<2%)
haloperidol, ketoconazole, levodopa, MAO Genitourinary
Herpes simplex (<2%)
inhibitors, memantine, metoclopramide, Urinary tract infection (7%)
Herpes zoster (<2%)
nefopam, parasympathomimetics, PEG- Ocular Hypersensitivity (<2%)
interferon, phenothiazines, potassium chloride, Cataract (<3%) Lipoatrophy (<2%)
pramlintide, secretin, sublingual nitrates, tricyclic
Other Lipodystrophy (<2%)
antidepressants
Adverse effects [12] Lipohypertrophy (<2%)
Allergic reactions (<3%) Pruritus (<2%)
Rash (3%) [2]
TIPRANAVIR See all our books at www.crcpress.com
Central Nervous System rocuronium, succinylcholine, teicoplanin,

Anorexia (<2%) TIZANIDINE torsemide, vecuronium
Depression (2%) Pregnancy category: D (category D for
Fever (14%) Trade name: Zanaflex (Acorda) injection and inhalation; category B for ophthalmic
Headache (5%) Indications: Muscle spasticity, multiple sclerosis use)
Insomnia (2%) Class: Adrenergic alpha2-receptor agonist Important contra-indications noted in the
Intracranial hemorrhage (<2%) [3] Half-life: 2.5 hours prescribing guidelines for: the elderly; nursing
Neurotoxicity (<2%) Clinically important, potentially hazardous mothers; pediatric patients
Peripheral neuropathy (2%) interactions with: acebutolol, alfuzosin, Note: Aminoglycosides may cause neurotoxicity
Sleep related disorder (<2%) benazepril, captopril, cilazapril, ciprofloxacin, and/or nephrotoxicity.
Somnolence (drowsiness) (<2%) enalapril, fluvoxamine, fosinopril, irbesartan, TobraDex is tobramycin and dexamethasone.
Vertigo (dizziness) (<2%) lisinopril, norfloxacin, obeticholic acid,
olmesartan, phenytoin, quinapril, ramipril,
Neuromuscular/Skeletal rofecoxib, teriflunomide, trandolapril Skin
Asthenia (fatigue) (2%) Pregnancy category: C Exanthems [4]
Cramps (<2%) Important contra-indications noted in the Hypersensitivity [3]
Myalgia/Myopathy (2%) prescribing guidelines for: the elderly; pediatric Rash [2]
Gastrointestinal/Hepatic patients Central Nervous System
Abdominal distension (<2%) Dysgeusia (taste perversion) [2]
Abdominal pain (6%) Skin Fever [2]
Dyspepsia (<2%) Pallor [2] Respiratory
Flatulence (<2%) Pruritus (<10%) Cough [3]
Gastroesophageal reflux (<2%) Rash (<10%)
Hepatic failure (<2%) Renal
Hepatitis (<2%) Mucosal Nephrotoxicity [6]
Hepatotoxicity [4] Xerostomia (49–88%) [14] Ocular
Nausea (9%) Cardiovascular Conjunctivitis [2]
Pancreatitis (<2%) Bradycardia (<10%) [5] Eyelid dermatitis [2]
Vomiting (6%) Hypotension (16–33%) [3] Intraocular pressure increased [2]
Dyspnea (2%) Dyskinesia (3%)
Flu-like syndrome (<2%) Nervousness (3%) TOCAINIDE
Endocrine/Metabolic Somnolence (drowsiness) (48–92%) [4]
ALT increased (2%) [2] Speech disorder (3%) See: www.drugeruptiondata.com/drug/id/700
Appetite decreased (<2%) Tremor (<10%)
Dehydration (2%) Vertigo (dizziness) (41–45%) [3]
Diabetes mellitus (<2%) Neuromuscular/Skeletal TOCILIZUMAB
GGT increased (2%) Asthenia (fatigue) (41–78%) [5]
Hyperamylasemia (<2%) Gastrointestinal/Hepatic Trade name: Actemra (Roche)
Hypercholesterolemia (<2%) Constipation (4%) Indications: Rheumatoid arthritis, juvenile
Hyperglycemia (<2%) Hepatotoxicity (6%) [4] idiopathic arthritis, Castleman’s disease
Hyperlipidemia (3%) Vomiting (3%) Class: Anti-interleukin-6 receptor monoclonal
Hypertriglyceridemia (4%) [2] antibody, Disease-modifying antirheumatic drug
Weight loss (3%) Respiratory (DMARD), Monoclonal antibody
Flu-like syndrome (3%) Half-life: 8–14 days
Hematologic Pharyngitis (3%)
Anemia (3%) Clinically important, potentially hazardous
Rhinitis (3%) interactions with: efavirenz, fesoterodine,
Neutropenia (2%)
Thrombocytopenia (<2%) Genitourinary fingolimod, infliximab, lurasidone, paricalcitol,
Urinary frequency (3%) pazopanib, typhoid vaccine, yellow fever vaccine
Other Urinary tract infection (10%) Pregnancy category: N/A (Based on animal
Adverse effects [3] data, may cause fetal harm)
Ocular
Amblyopia (3%)
TIROFIBAN Other
Infection (6%)
pediatric patients
Warning: RISK OF SERIOUS INFECTIONS
Skin
TOBRAMYCIN Anaphylactoid reactions/Anaphylaxis [5]
TIXOCORTOL Trade names: TOBI (Chiron), TobraDex (Alcon)
Cellulitis [9]
Herpes zoster [8]
See: www.drugeruptiondata.com/drug/id/1099 Indications: Various serious infections caused by Hypersensitivity [5]
susceptible organisms, superficial ocular infections Malignancies [2]
Class: Antibiotic, aminoglycoside Peripheral edema (<2%)
Half-life: 23 hours Psoriasis [2]
Clinically important, potentially hazardous Rash (2%) [6]
interactions with: adefovir, aldesleukin, Urticaria [2]
aminoglycosides, atracurium, bumetanide,
daptomycin, doxacurium, ethacrynic acid,
Mucosal
Mucosal ulceration [2]
furosemide, neuromuscular blockers,
Oral ulceration (2%)
pancuronium, polypeptide antibiotics,
Stomatitis (<2%)
Litt’s Drug Eruption & Reaction Manual TOLTERODINE
Cardiovascular Other
Cardiotoxicity [3] TOFACITINIB Adverse effects [8]
Hypertension (6%) [3] Infection (20–22%) [11]
Trade name: Xeljanz (Pfizer)
Central Nervous System Indications: Rheumatoid arthritis
Headache (7%) [7] Class: Janus kinase (JAK) inhibitor
Neurotoxicity [2] Half-life: ~3 hours TOLAZAMIDE
Vertigo (dizziness) (3%) Clinically important, potentially hazardous
Neuromuscular/Skeletal interactions with: azathioprine, biologic See: www.drugeruptiondata.com/drug/id/701
Arthralgia [4] disease-modifying antirheumatics, cyclosporine,
Fractures [2] CYP3A4 inhibitors, fluconazole, ketoconazole,
Gastrointestinal/Hepatic live vaccines, potent immunosuppressives, TOLAZOLINE
Abdominal pain (2%) rifampin, strong CYP inducers, strong CYP2C19
Diarrhea [2] inhibitors, tacrolimus See: www.drugeruptiondata.com/drug/id/702
Gastroenteritis [6] Pregnancy category: C
Gastrointestinal bleeding [3] Important contra-indications noted in the
Gastrointestinal perforation [8] prescribing guidelines for: the elderly; nursing
TOLBUTAMIDE
Gastrointestinal ulceration (<2%)
Hepatotoxicity [15] Warning: SERIOUS INFECTIONS AND See: www.drugeruptiondata.com/drug/id/703
Nausea [3] MALIGNANCY
Pancreatitis [2]
Respiratory Skin TOLCAPONE
Bronchitis (3%) [6] Erythema (<2%)
Cough (<2%) Herpes zoster [5] See: www.drugeruptiondata.com/drug/id/704
Dyspnea (<2%) Peripheral edema (<2%)
Influenza [3] Pruritus (<2%)
Rash (<2%) [3]
Nasopharyngitis (7%) [7]
Pharyngitis [3] Mucosal
TOLMETIN
Pneumonia [12] Nasal congestion (<2%) See: www.drugeruptiondata.com/drug/id/705
Pneumothorax [2] Cardiovascular
Pulmonary toxicity [5] Hypertension (2%)
Endocrine/Metabolic
Central Nervous System TOLTERODINE
Fever (<2%)
ALT increased (6%) [10] Headache (3–4%) [10] Trade name: Detrol (Pharmacia & Upjohn)
AST increased [4] Insomnia (<2%) Indications: Urinary incontinence
Hypercholesterolemia [4] Paresthesias (<2%) Class: Muscarinic antagonist
Hyperlipidemia [5] Half-life: 24 hours
Hypertriglyceridemia [2] Neuromuscular/Skeletal
Arthralgia (<2%) Clinically important, potentially hazardous
Hypothyroidism (<2%) interactions with: itraconazole, ketoconazole,
Weight gain (<2%) Bone or joint pain (<2%)
Tendinitis (<2%) lopinavir, nelfinavir, sotalol, voriconazole, warfarin
Genitourinary Pregnancy category: C
Urinary tract infection [3] Gastrointestinal/Hepatic Important contra-indications noted in the
Abdominal pain (<2%) [2] prescribing guidelines for: nursing mothers;
Renal Diarrhea (3–4%) [8] pediatric patients
Nephrolithiasis (<2%) Dyspepsia (<2%) [2]
Pyelonephritis [3] Gastritis (<2%)
Hematologic Nausea (<2%) [3] Skin
Vomiting (<2%) Erythema (2%)
Hemotoxicity [2]
Rash (2%)
Leukopenia (<2%) [5] Respiratory
Lymphopenia [2] Bronchitis [3] Mucosal
Neutropenia [19] Cough (<2%) Xerostomia (35%) [38]
Sepsis [2] Dyspnea (<2%) Cardiovascular
Ocular Influenza [2] Chest pain (2%)
Conjunctivitis (<2%) Nasopharyngitis (3–4%) [8] Central Nervous System
Local Tuberculosis [3] Headache (7%) [4]
Infusion-related reactions [3] Upper respiratory tract infection (4–5%) [8] Somnolence (drowsiness) (3%)
Infusion-site reactions [2] Endocrine/Metabolic Vertigo (dizziness) (5%) [4]
Other ALT increased [2] Neuromuscular/Skeletal
Adverse effects [11] AST increased [2] Arthralgia (2%)
Death [5] Creatine phosphokinase increased [2] Asthenia (fatigue) (4%)
Infection [39] Dehydration (<2%)
Genitourinary Abdominal pain (5%) [2]
Urinary tract infection (2%) [5] Constipation (7%) [13]
Hematologic Diarrhea (4%)
Anemia (<2%) Dyspepsia (4%)
Neutropenia [3] Respiratory
TOLTERODINE Over 100 updates per week on www.drugeruptiondata.com
Genitourinary Paresthesias (>5%) [33] Neuromuscular/Skeletal

Dysuria (2%) Psychosis [3] Asthenia (fatigue) [9]
Ocular Seizures [3] Gastrointestinal/Hepatic
Vision blurred [3] Somnambulism [2] Abdominal pain [2]
Xerophthalmia (3%) [2] Somnolence (drowsiness) (>5%) [5] Diarrhea [5]
Suicidal ideation [2] Hepatotoxicity [3]
Other Tremor (>10%)
Adverse effects [6] Nausea [3]
Vertigo (dizziness) (>5%) [12] Vomiting [4]
Neuromuscular/Skeletal Respiratory
TOLVAPTAN Asthenia (fatigue) (>5%) [9] Dyspnea [3]
Ataxia [2]
See: www.drugeruptiondata.com/drug/id/1384 Renal
Gastrointestinal/Hepatic Nephrotoxicity [2]
Constipation [5]
TOPIRAMATE Diarrhea [3] Hematologic
Anemia [11]
Nausea [5]
Trade names: Qsymia (Vivus), Qudexy (Upsher- Febrile neutropenia [5]
Respiratory Granulocytopenia [2]
Smith), Topamax (Janssen), Trokendi XR Flu-like syndrome (<2%)
(Supernus) Myelosuppression [2]
Indications: Partial onset seizures, migraine Endocrine/Metabolic Neutropenia [16]
Class: Anticonvulsant, Mood stabilizer Acidosis [4] Thrombocytopenia [15]
Half-life: 21 hours Appetite decreased [4] Other
Clinically important, potentially hazardous Gynecomastia (8%) Adverse effects [2]
interactions with: eslicarbazepine, Hyperammonemia [2] Death [5]
levonorgestrel, metformin, rufinamide, ulipristal, Mastodynia (39%) Infection [2]
valproic acid Weight gain [2]
Pregnancy category: D Weight loss (>5%) [15]
Important contra-indications noted in the Genitourinary TOREMIFENE
prescribing guidelines for: nursing mothers; Erectile dysfunction [2]
pediatric patients Renal Trade name: Fareston (ProStrakan)
Note: Qsymia is topiramate and phentermine. Nephrolithiasis [5] Indications: Metastatic breast cancer
Ocular Class: Selective estrogen receptor modulator
Skin Diplopia [2] (SERM)
Anhidrosis [2] Glaucoma [16] Half-life: ~5 days
Bromhidrosis (2%) Myopia [9] Clinically important, potentially hazardous
Diaphoresis (2%) Uveitis [5] interactions with: amoxapine, arsenic,
Edema (2%) Vision loss [3] dolasetron, efavirenz, pazopanib, sugammadex,
Fixed eruption [2] telavancin
Hot flashes (<10%) Other Pregnancy category: D
Hypohidrosis [2] Adverse effects [11] Important contra-indications noted in the
Palmar erythema [2] Death [2] prescribing guidelines for: nursing mothers;
Pruritus (2%) [3] Infection (>5%) pediatric patients
Rash (4%) [3] Side effects [3] Warning: QT PROLONGATION
Teratogenicity [8]
Hair
Alopecia [2] Skin
Mucosal Diaphoresis (20%) [6]
Gingival hyperplasia/hypertrophy [2]
TOPOTECAN Edema (5%) [2]
Gingivitis (2%) Hot flashes (35%) [4]
Trade name: Hycamtin (GSK)
Xerostomia (3%) [5] Indications: Metastatic ovarian carcinoma Cardiovascular
Cardiovascular Class: Antineoplastic, Topoisomerase 1 inhibitor Flushing [3]
Flushing (>5%) Half-life: 3–6 hours Thromboembolism [3]
Tachycardia [3] Clinically important, potentially hazardous Venous thromboembolism [2]
Central Nervous System interactions with: atorvastatin, darunavir, Central Nervous System
Anorexia (>5%) [4] gefitinib, lapatinib, oxaliplatin, pantoprazole, Headache [2]
Anxiety [3] safinamide, sofosbuvir & velpatasvir Vertigo (dizziness) [2]
Cognitive impairment (>5%) [16] Pregnancy category: D Gastrointestinal/Hepatic
Confusion (>5%) Important contra-indications noted in the Hepatotoxicity [3]
Depression [11] prescribing guidelines for: nursing mothers; Nausea [2]
Dysgeusia (taste perversion) (>5%) [9] pediatric patients Vomiting [2]
Encephalopathy [3] Warning: BONE MARROW SUPPRESSION
Endocrine/Metabolic
Fever (>5%) ALP increased [2]
Headache [2] Hair Galactorrhea (<10%)
Hyperthermia [3] Alopecia (59%) [7]
Impaired concentration [3] Genitourinary
Mucosal Priapism (<10%)
Insomnia [7] Mucositis [2]
Irritability [2] Vaginal bleeding [2]
Stomatitis (24%) [4] Vaginal discharge [2]
Nervousness (>5%)
Neurotoxicity [5] Central Nervous System Ocular
Palinopsia [3] Fever [2] Cataract [3]
Paresthesias (9%)
Litt’s Drug Eruption & Reaction Manual TRAMETINIB
Respiratory depression [2]

TORSEMIDE TRAMADOL Endocrine/Metabolic
Trade names: Demadex (Roche), Torem Trade names: Rybix ODT (Victory Pharma), Adrenal insufficiency [2]
(Roche) Ultracet (Ortho-McNeil), Ultram (Ortho-McNeil) Hypoglycemia [7]
Indications: Essential hypertension, edema due Indications: Pain Hyponatremia [3]
to congestive heart failure, hepatic, pulmonary or Class: Opiate agonist Genitourinary
renal edema Half-life: 67 hours Urinary frequency (<5%)
Class: Diuretic, loop Clinically important, potentially hazardous Urinary retention (<5%)
Half-life: 24 hours interactions with: alcohol, amitriptyline, Otic
Clinically important, potentially hazardous carbamazepine, cinacalcet, citalopram, Hallucinations, auditory [2]
interactions with: ACE inhibitors, amikacin, delavirdine, desflurane, desvenlafaxine,
aminoglycosides, aminophylline, anti-diabetics, duloxetine, erythromycin, fluoxetine, Ocular
antihypertensives, cephalosporins, cisplatin, fluvoxamine, ketoconazole, levomepromazine, Hallucinations, visual [3]
gentamicin, indomethacin, kanamycin, neomycin, linezolid, lorcaserin, MAO inhibitors, nefazodone, Mydriasis [2]
probenecid, salicylates, streptomycin, tobramycin ondansetron, paroxetine hydrochloride, Visual disturbances (<5%)
Pregnancy category: B phenelzine, quinidine, risperidone, safinamide, Other
Important contra-indications noted in the tapentadol, terbinafine, tianeptine, tipranavir, Adverse effects [8]
prescribing guidelines for: nursing mothers; tranylcypromine, venlafaxine, vilazodone, Death [2]
pediatric patients zuclopenthixol
Note: Torsemide is a sulfonamide and can be Pregnancy category: C
severe, possibly fatal, reactions such as toxic
TRAMETINIB
epidermal necrolysis and Stevens-Johnson mothers; pediatric patients Trade name: Mekinist (Novartis)
syndrome. Indications: Melanoma (unresectable or
Skin metastatic) in patients with BRAF V600E or
Skin Anaphylactoid reactions/Anaphylaxis [2] V600K mutations
Photosensitivity (<10%) Angioedema [2] Class: MEK inhibitor
Urticaria (<10%) Contact dermatitis [2] Half-life: 4–5 days
Vasculitis [2] Diaphoresis (9%) [3] Clinically important, potentially hazardous
Central Nervous System Hypersensitivity [2] interactions with: none known
Headache (7%) Peripheral edema [2] Pregnancy category: D
Vertigo (dizziness) (3%) Pruritus (<10%) [4] Important contra-indications noted in the
Rash (<5%) [2] prescribing guidelines for: nursing mothers;
Neuromuscular/Skeletal Urticaria (<18%) pediatric patients
Arthralgia (2%)
Asthenia (fatigue) (2%) Mucosal
Myalgia/Myopathy (2%) Xerostomia (10%) [5] Skin
Cardiovascular Acneform eruption (19%) [7]
Gastrointestinal/Hepatic Actinic keratoses [2]
Constipation (2%) Flushing [2]
Vasodilation (<5%) Cellulitis (<10%)
Diarrhea (2%) Dermatitis (19%) [2]
Dyspepsia (2%) Central Nervous System Edema (32%)
Nausea (2%) Anorexia (<5%) Erythema [2]
Respiratory Anxiety (<5%) Exanthems [2]
Cough (2%) Catatonia [2] Folliculitis (<10%)
Pharyngolaryngeal pain (2%) Confusion (<5%) Keratosis pilaris [2]
Rhinitis (3%) Euphoria (<5%) Lymphedema (32%)
Fever [2] Panniculitis [4]
Endocrine/Metabolic Headache [8]
Pseudoporphyria [2] Papulopustular eruption [2]
Insomnia [3] Peripheral edema (32%) [7]
Nervousness (<5%) Pruritus (10%) [3]
Restless legs syndrome [5] Pustules (<10%)
TOSITUMOMAB & Seizures [16] Rash (57%) [16]
IODINE131 Sleep related disorder (<5%)
Squamous cell carcinoma [3]
Toxicity (87%) [5]
Somnolence (drowsiness) [7] Xerosis (11%) [2]
See: www.drugeruptiondata.com/drug/id/1015 Tremor (510%)
Vertigo (dizziness) [18] Hair
Alopecia [3]
TOSUFLOXACIN Asthenia (fatigue) (<5%) [3] Nails
Hypertonia (<5%) Paronychia (10%)
See: www.drugeruptiondata.com/drug/id/1309 Mucosal
Abdominal pain (<5%) [3] Aphthous stomatitis (15%)
Constipation [8] Epistaxis (nosebleed) (13%)
TRABECTEDIN Diarrhea [2] Gingival bleeding (13%)
Flatulence (<5%) Mucosal inflammation (15%)
See: www.drugeruptiondata.com/drug/id/1385 Nausea [25] Oral ulceration (15%)
Vomiting [23] Rectal hemorrhage (13%)
Stomatitis (15%) [2]
Respiratory Xerostomia (<10%)
Apnea [2]
TRAMETINIB See all our books at www.crcpress.com
Cardiovascular sulfonylureas, tizanidine, triamterene,

Bradycardia (<10%) trimethoprim TRANYLCYPROMINE
Cardiomyopathy (7%) Pregnancy category: D (category C in first
Cardiotoxicity [5] trimester; category D in second and third See: www.drugeruptiondata.com/drug/id/713
Hypertension (15%) [6] trimesters)
Chills [2]
prescribing guidelines for: nursing mothers; TRASTUZUMAB
pediatric patients
Note: Contra-indicated in patients with Trade name: Herceptin (Genentech)
Fever [7]
hereditary/idiopathic angioedema and in patients Indications: Metastatic breast cancer
Headache [3]
with a history of angioedema related to previous Class: Antineoplastic, HER2/neu receptor
treatment with an ACE inhibitor. Tarka is antagonist, Monoclonal antibody
Neuromuscular/Skeletal trandolapril and verapamil. Half-life: 2–16 days (dose dependent)
Arthralgia [3] Warning: FETAL TOXICITY Clinically important, potentially hazardous
Asthenia (fatigue) [13] interactions with: abatacept, abciximab,
Rhabdomyolysis (<10%) alefacept, antineoplastics, azacitidine,
Skin
Gastrointestinal/Hepatic Angioedema [3] betamethasone, cabazitaxel, denileukin,
Abdominal pain (13%) Edema (>3%) docetaxel, doxorubicin, fingolimod, gefitinib,
Black stools (13%) immunosuppressants, leflunomide, lenalidomide,
Mucosal
Constipation [2] oxaliplatin, paclitaxel, pazopanib, pemetrexed,
Xerostomia (>3%)
Diarrhea (43%) [15] temsirolimus
Hepatotoxicity [2] Cardiovascular Pregnancy category: D
Nausea [11] Bradycardia (5%) Important contra-indications noted in the
Vomiting [5] Cardiogenic shock (4%) prescribing guidelines for: nursing mothers;
Hypotension (11%) pediatric patients
Respiratory
Pneumonitis (2%) Central Nervous System Warning: CARDIOMYOPATHY, INFUSION
Hyperesthesia (>3%) REACTIONS, EMBRYO-FETAL TOXICITY, and
Endocrine/Metabolic PULMONARY TOXICITY
Stroke (3%)
ALP increased (24%)
Syncope (6%)
Vertigo (dizziness) (23%) Skin
AST increased (60%) [3] Neuromuscular/Skeletal Acneform eruption (2%) [4]
Hypoalbuminemia (42%) Asthenia (fatigue) (3%) Edema (8%)
Myalgia/Myopathy (5%) Erythema [2]
Genitourinary Hand–foot syndrome [10]
Hematuria (13%) Gastrointestinal/Hepatic Herpes simplex (2%)
Vaginal bleeding (13%) Dyspepsia (6%) Hypersensitivity [2]
Gastritis (4%) Peripheral edema (5–10%)
Hematologic
Anemia (38%) [3] Respiratory Photosensitivity [2]
Hemorrhage (13%) Cough (35%) [5] Pruritus (2%)
Neutropenia [2] Endocrine/Metabolic Radiation recall dermatitis [2]
Thrombocytopenia [3] Creatine phosphokinase increased (5%) Rash (4–18%) [11]
Hyperkalemia (5%) Toxicity [3]
Ocular
Chorioretinopathy [2] Hypocalcemia (5%) Hair
Conjunctival hemorrhage (13%) Alopecia [6]
Retinopathy [2] Nails
Vision blurred (<10%) [2] TRANEXAMIC ACID Nail disorder (2%)
Xerophthalmia (<10%)
Mucosal
Other Trade name: Cyklokapron (Pharmacia)
Epistaxis (nosebleed) (2%)
Adverse effects [5] Indications: Fibrinolysis
Mucositis [3]
Class: Antifibrinolytic
Stomatitis [4]
Half-life: 2 hours
TRANDOLAPRIL Clinically important, potentially hazardous Cardiovascular
interactions with: none known Arrhythmias (3%)
Trade names: Mavik (AbbVie), Tarka (AbbVie) Pregnancy category: B Cardiac disorder [4]
Indications: Hypertension Cardiac failure [4]
Class: Angiotensin-converting enzyme (ACE) Cardiomyopathy [2]
inhibitor, Antihypertensive, Vasodilator Skin Cardiotoxicity [26]
Half-life: 6 hours Fixed eruption [2]
Congestive heart failure (2–7%) [7]
Clinically important, potentially hazardous Central Nervous System Hypertension (4%) [3]
interactions with: alcohol, aldesleukin, aliskiren, Headache [3] Myocardial toxicity [3]
allopurinol, alpha blockers, amiloride, angiotensin Seizures [11] Palpitation (3%)
II receptor antagonists, antacids, antidiabetics, Tachycardia (5%)
antipsychotics, anxiolytics and hypnotics, Gastrointestinal/Hepatic
baclofen, beta blockers, calcium channel blockers, Abdominal pain [2] Central Nervous System
clonidine, corticosteroids, cyclosporine, Endocrine/Metabolic Anorexia (14%) [3]
diazoxide, diuretics, estrogens, general Menstrual irregularities [3] Chills (5–32%) [8]
anesthetics, gold & gold compounds, heparins, Depression (6%)
hydralazine, insulin, levodopa, lithium, MAO
Renal Fever (6–36%) [6]
inhibitors, metformin, methyldopa, minoxidil, Nephrotoxicity [3] Headache (10–26%) [2]
moxisylyte, moxonidine, nitrates, nitroprusside, Other Insomnia (14%)
NSAIDs, potassium salts, spironolactone, Adverse effects [2] Neurotoxicity [4]
Litt’s Drug Eruption & Reaction Manual TREPROSTINIL
Pain (47%) [2] Pregnancy category: C

Paresthesias (2–9%) Important contra-indications noted in the TRAZODONE
Peripheral neuropathy [5] prescribing guidelines for: nursing mothers;
Vertigo (dizziness) (4–13%) pediatric patients Trade names: Desyrel (Bristol-Myers Squibb),
Oleptro (Angelini)
Neuromuscular/Skeletal Indications: Depression
Arthralgia (6–8%) [4] Cardiovascular Class: Antidepressant, tricyclic, Serotonin
Asthenia (fatigue) (5–47%) [17] Angina (<5%) reuptake inhibitor
Back pain (5–22%) Bradycardia (<5%) Half-life: 36 hours
Bone or joint pain (3–7%) Chest pain (<5%) Clinically important, potentially hazardous
Muscle spasm (3%) Hypertension (<5%) [2] interactions with: amiodarone, amprenavir,
Myalgia/Myopathy (4%) [3] Hypotension (<5%) atazanavir, boceprevir, citalopram, cobicistat/
Gastrointestinal/Hepatic Central Nervous System elvitegravir/emtricitabine/tenofovir alafenamide,
Abdominal pain (2–22%) Anxiety (<5%) cobicistat/elvitegravir/emtricitabine/tenofovir
Constipation (2%) Depression (<5%) disoproxil, darunavir, delavirdine, fluoxetine,
Diarrhea (7–25%) [29] Dysgeusia (taste perversion) [3] fluvoxamine, ginkgo biloba, indinavir, linezolid,
Dyspepsia (2%) Headache (<5%) lopinavir, MAO inhibitors, nefazodone, paroxetine
Hepatotoxicity [8] Pain (<5%) hydrochloride, sertraline, tapentadol, telaprevir,
Nausea (6–33%) [8] Neuromuscular/Skeletal tipranavir, venlafaxine
Vomiting (4–23%) [4] Arthralgia (<5%) Pregnancy category: C
Respiratory Back pain (<5%) Important contra-indications noted in the
Cough (5–26%) prescribing guidelines for: nursing mothers;
Gastrointestinal/Hepatic pediatric patients
Dyspnea (3–22%) Dyspepsia (<5%)
Flu-like syndrome (10%) [3] Warning: SUICIDALITY IN CHILDREN AND
Gastrointestinal disorder (<5%) ADOLESCENTS
Influenza (4%) Nausea [2]
Pharyngitis (12%) Respiratory Skin
Pharyngolaryngeal pain (2%) Bronchitis (<5%) Edema (<10%)
Pneumonia [2] Flu-like syndrome (<5%) Exanthems [6]
Pneumonitis [2] Sinusitis (<5%) Photosensitivity [2]
Pulmonary toxicity [4] Endocrine/Metabolic Psoriasis (exacerbation) [2]
Rhinitis (2–14%) Hypercholesterolemia (<5%) Urticaria [3]
Sinusitis (2–9%) Genitourinary Hair
Upper respiratory tract infection (3%) Prostatitis (<5%) Alopecia [2]
Endocrine/Metabolic Urinary incontinence (<5%) Mucosal
ALT increased [5] Urinary tract infection (<5%) Xerostomia (>10%) [6]
Appetite decreased [2] Ocular
AST increased [3] Cardiovascular
Abnormal vision (<4%) Arrhythmias [2]
Hyperbilirubinemia [2] Blepharitis (<4%)
Hyperglycemia [3] QT prolongation [2]
Cataract (<4%)
Genitourinary Conjunctival hyperemia [10] Central Nervous System
Urinary tract infection (3–5%) Conjunctivitis (<4%) Dysgeusia (taste perversion) (>10%)
Corneal staining (<4%) Headache [3]
Hematologic Sedation (>5%)
Anemia (4%) [7] Deepening of upper lid sulcus [7]
Eyelashes – hypertrichosis [3] Serotonin syndrome [7]
Febrile neutropenia [15] Somnolence (drowsiness) (>5%) [3]
Leukopenia (3%) [10] Eyelid crusting (<4%)
Foreign body sensation (5–10%) Tremor (<10%)
Neutropenia [27] Vertigo (dizziness) (>5%) [4]
Thrombocytopenia [6] Iris pigmentation (<4%) [2]
Keratitis (<4%) Neuromuscular/Skeletal
Local Lacrimation (<4%) Myalgia/Myopathy (<10%)
Infusion-related reactions [4] Ocular adverse effects [4]
Injection-site reactions (21–40%) [6] Gastrointestinal/Hepatic
Ocular hemorrhage (3550%) Constipation (>5%)
Other Ocular hyperemia [7] Nausea [2]
Adverse effects [4] Ocular inflammation (<4%)
Allergic reactions (3%) [2] Ocular pain (5–10%) Genitourinary
Death [5] Ocular pigmentation (<5%) [4] Priapism (12%) [23]
Infection (20%) [2] Ocular pruritus (510%) [6] Sexual dysfunction [2]
Ocular stinging (510%) Ocular
Photophobia (<4%) Vision blurred (>5%)
TRAVOPROST Reduced visual acuity (5–10%)
Subconjunctival hemorrhage (<4%)
Uveitis [5]
Trade names: Izba (Alcon), Travatan (Alcon),
Vision blurred [2]
TREPROSTINIL
Travatan Z (Alcon)
Indications: Reduction of elevated intraocular Xerophthalmia (<4%) See: www.drugeruptiondata.com/drug/id/953
pressure in open-angle glaucoma or ocular Other
hypertension Allergic reactions (<5%)
Class: Prostaglandin analog Infection (<5%)
Half-life: N/A
TRETINOIN Over 100 updates per week on www.drugeruptiondata.com
Pain [O] (37%)

TRETINOIN Paresthesias [O] (17%) TRIAZOLAM
Pseudotumor cerebri [O] [11]
Synonyms: all-trans-retinoic acid; ATRA Shivering [O] (63%) See: www.drugeruptiondata.com/drug/id/716
Trade names: Aknemycin Plus (EM Industries), Tremor [O] (<10%)
Renova (Ortho), Retin-A Micro (Ortho), Solage
(Galderma), Vesanoid (Roche)
Indications: Acne vulgaris, skin aging, facial Arthralgia [O] (10%) [3] TRICHLORMETHIAZIDE
roughness, fine wrinkles, hyperpigmentation [T], Bone or joint pain [O] (77%) [3]
Myalgia/Myopathy (14%) [3] See: www.drugeruptiondata.com/drug/id/717
acute promyelocytic leukemia [O]
Class: Antineoplastic, Retinoid Gastrointestinal/Hepatic
Half-life: 0.52 hours Hepatotoxicity [3]
Clinically important, potentially hazardous Pancreatitis [2] TRIENTINE
interactions with: aldesleukin, bexarotene Hematologic
Pregnancy category: D (category B (topical), See: www.drugeruptiondata.com/drug/id/718
Hemorrhage [2]
category C (oral), category D in third trimester)
prescribing guidelines for: nursing mothers; Diplopia [2]
Ocular pigmentation [O] (<10%)
TRIFLUOPERAZINE
pediatric patients
Note: Oral retinoids can cause birth defects, and Ocular pruritus [O] (10%) See: www.drugeruptiondata.com/drug/id/719
women should avoid tretinoin when pregnant or Xerophthalmia [O] (<10%) [2]
trying to conceive. Avoid prolonged exposure to Local
sunlight.
[T] = Topical; [O] = Oral.
Injection-site reactions (17%) TRIFLURIDINE
Other
Death [O] [2] See: www.drugeruptiondata.com/drug/id/1205
Skin Infection [O] (58%)
Burning [O][T] (1040%) [20]
Cellulitis [O] (<10%)
TRIFLURIDINE &
TRIAMCINOLONE
Crusting [2] TIPIRACIL
Dermatitis [7] See: www.drugeruptiondata.com/drug/id/1108
Desquamation (14%) Trade name: Lonsurf (Monarch)
Diaphoresis (20%) Indications: Metastatic colorectal cancer in
Differentiation syndrome [O] (25%) [19] patients who have been previously treated with
Edema (29%) [8] TRIAMTERENE fluoropyrimidine-, oxaliplatin-and irinotecan-
Erythema [O][T] (<49%) [19] based chemotherapy, an anti-VEGF biological
Erythema nodosum [4] Trade names: Dyazide (GSK), Dyrenium therapy, and if RAS wild-type, an anti-EGFR
Exfoliative dermatitis [O] (8%) [3] (Concordia) therapy
Facial edema [O] (<10%) Indications: Edema Class: Antineoplastic, Thymidine phosphorylase
Flaking [O] (23%) Class: Diuretic, potassium-sparing inhibitor, Thymidine-based nucleoside analogue
Hyperkeratosis [O] (78%) Half-life: 12 hours Half-life: 2 hours
Hypomelanosis (5%) [2] Clinically important, potentially hazardous Clinically important, potentially hazardous
Pallor [O] (<10%) interactions with: ACE inhibitors, acemetacin, interactions with: none known
Palmar–plantar desquamation [O] (<10%) benazepril, captopril, cyclosporine, enalapril, Pregnancy category: N/A (Can cause fetal
Peeling [4] fosinopril, indomethacin, lisinopril, metformin, harm)
Photosensitivity [O][T] (10%) [3] moexipril, potassium iodide, potassium salts, Important contra-indications noted in the
Pigmentation (5%) [3] quinapril, ramipril, spironolactone, trandolapril, prescribing guidelines for: nursing mothers;
Pruritus [O][T] (5–40%) [14] zofenopril pediatric patients
Rash [O][T] (54%) [3] Pregnancy category: C Note: See also separate entry for trifluridine.
Scaling (1040%) [16] Important contra-indications noted in the
Stinging (<26%) [8] prescribing guidelines for: nursing mothers;
pediatric patients Hair
Note: Dyazide and Maxzide are triamterene and Alopecia (7%)
Ulcerations (scrotal) [9]
Vasculitis [2] hydrochlorothiazide. Hydrochlorothiazide is a Mucosal
Xerosis [O] (49100%) [19] sulfonamide and can be absorbed systemically. Stomatitis (8%)
Sulfonamides can produce severe, possibly fatal,
Hair Central Nervous System
Alopecia areata [O] (14%) Dysgeusia (taste perversion) (7%)
Fever (19%)
Nails
Pyogenic granuloma [3] Neuromuscular/Skeletal
Skin
Mucosal Edema (<10%)
Cheilitis [O] (10%) Lupus erythematosus (with Gastrointestinal/Hepatic
Xerostomia [O] (10%) hydrochlorothiazide) [2] Abdominal pain (21%) [2]
Photosensitivity [2] Diarrhea (32%) [2]
Cardiovascular
Rash (<10%) Nausea (48%) [3]
Phlebitis (11%)
Vomiting (28%)
Central Nervous System Respiratory
Depression [O] (14%)
Fever [O] [6]
Pulmonary embolism (2%)
Headache [2]
Intracranial pressure increased [2]
Litt’s Drug Eruption & Reaction Manual TYPHOID VACCINE
Endocrine/Metabolic Skin
Appetite decreased (39%) DRESS syndrome [2] TRIPELENNAMINE
Genitourinary Fixed eruption [6]
Pruritus (<10%) See: www.drugeruptiondata.com/drug/id/728
Rash (37%)
Hematologic Stevens-Johnson syndrome [5]
Anemia (77%) [7]
Toxic epidermal necrolysis [3] TRIPROLIDINE
Granulocytopenia [3] Central Nervous System
Aseptic meningitis [3] See: www.drugeruptiondata.com/drug/id/729
Leukopenia [7]
Neutropenia (67%) [9] Neuromuscular/Skeletal
Thrombocytopenia (42%) [3] Rhabdomyolysis [3]
Other Gastrointestinal/Hepatic
TRIPTORELIN
Infection (27%) Hepatotoxicity [2] See: www.drugeruptiondata.com/drug/id/814
Endocrine/Metabolic
Hyperkalemia [3]
TRIHEXYPHENIDYL Hyponatremia [2] TROGLITAZONE
Hematologic
See: www.drugeruptiondata.com/drug/id/720 Anemia [2] See: www.drugeruptiondata.com/drug/id/1861
TRIMEPRAZINE TROLEANDOMYCIN
TRIMETREXATE
TRIMETHADIONE TROSPIUM
TRIMIPRAMINE
Trade name: Surmontil (Odyssey)
Indications: Major depression
TRIMETHOBENZAMIDE Class: Antidepressant, tricyclic TROVAFLOXACIN
See: www.drugeruptiondata.com/drug/id/723 Clinically important, potentially hazardous See: www.drugeruptiondata.com/drug/id/732
interactions with: amprenavir, arbutamine,
bupropion, clonidine, epinephrine, formoterol,
TRIMETHOPRIM guanethidine, isocarboxazid, linezolid, MAO
inhibitors, phenelzine, quinolones, sparfloxacin, TRYPTOPHAN
Trade names: Bactrim (Women First), Septra tranylcypromine, venlafaxine
Pregnancy category: C See: www.drugeruptiondata.com/drug/id/798
(Monarch)
Indications: Various urinary tract infections Important contra-indications noted in the
caused by susceptible organisms, acute otitis prescribing guidelines for: pediatric patients
media in children, acute and chronic bronchitis Warning: SUICIDALITY AND TYPHOID VACCINE
Class: Antibiotic ANTIDEPRESSANT DRUGS
Half-life: 810 hours Trade names: Typherix (GSK), Typhim Vi (Sanofi
Clinically important, potentially hazardous Skin Pasteur), Vivotif (Berna Biotech)
interactions with: ACE inhibitors, amantadine, Indications: Immunization against typhoid fever
Diaphoresis (<10%)
angiotensin II receptor antagonists, antidiabetics, Class: Vaccine
Mucosal Half-life: N/A
azathioprine, benazepril, captopril, carvedilol, Xerostomia (>10%) [2]
cilazapril, conivaptan, coumarins, cyclosporine, Clinically important, potentially hazardous
CYP2C8 substrates, CYP2C9 inhibitors, CYP3A4 Cardiovascular interactions with: alcohol, antibiotics,
inducers, dapsone, deferasirox, digoxin, QT prolongation [2] antimalarials, atovaquone/proguanil, azathioprine,
dofetilide, enalapril, eplerenone, fosinopril, belimumab, cefixime, ceftaroline fosamil,
irbesartan, lamivudine, leucovorin, ceftobiprole, chloroquine, ciprofloxacin,
Dysgeusia (taste perversion) (>10%)
levoleucovorin, lisinopril, memantine, corticosteroids, daptomycin, fingolimod,
Parkinsonism (<10%)
mercaptopurine, metformin, methotrexate, gemifloxacin, hydroxychloroquine,
Seizures [4]
olmesartan, oral typhoid vaccine, PEG-interferon, immunosuppressants, interferon gamma,
phenytoin, pioglitazone, pralatrexate, leflunomide, mefloquine, mercaptopurine,
procainamide, pyrimethamine, quinapril, ramipril, sulfonamides, telavancin, tigecycline, tinidazole,
repaglinide, rifampin, sulfonylureas, trandolapril
TRIOXSALEN tocilizumab, ustekinumab
prescribing guidelines for: nursing mothers prescribing guidelines for: nursing mothers;
Note: Although trimethoprim has been known to pediatric patients
elicit occasional adverse reactions by itself, it is Note: Vivotif is a live oral vaccine.
most commonly used in conjunction with
sulfamethoxazole (co-trimoxazole - see separate Skin
entry). Anaphylactoid reactions/Anaphylaxis [2]
TYPHOID VACCINE See all our books at www.crcpress.com
Central Nervous System Gastrointestinal/Hepatic Injection-site erythema (4–5%) [2]

Fever (<3%) [5] Abdominal pain (6%) [2] Injection-site induration (5–15%)
Headache (5–20%) [3] Diarrhea (<3%) Injection-site pain (27–41%) [5]
Myelitis [2] Nausea (2–8%) Other
Neuromuscular/Skeletal Vomiting (2%) Adverse effects [4]
Asthenia (fatigue) (4–24%) [3] Local Death [2]
Myalgia/Myopathy (3–7%) [3] Injection-site edema [3]
Litt’s Drug Eruption & Reaction Manual USTEKINUMAB

ULIPRISTAL URIDINE TRIACETATE Pharyngitis (8%)
Rhinitis (5%)
See: www.drugeruptiondata.com/drug/id/1421 See: www.drugeruptiondata.com/drug/id/3997 Sinusitis (5–11%)
Endocrine/Metabolic
UMECLIDINIUM UROFOLLITROPIN Weight gain [2]
Trade name: Incruse (GSK) See: www.drugeruptiondata.com/drug/id/990 Genitourinary
Indications: Chronic obstructive pulmonary Dysmenorrhea (5%)
disease (COPD) Urinary tract infection (6%)
Class: Anticholinergic, Muscarinic antagonist
UROKINASE Hematologic
Half-life: 11 hours Leukopenia (3%)
Clinically important, potentially hazardous Other
interactions with: anticholinergics Adverse effects [3]
Pregnancy category: C URSODIOL Allergic reactions (5%)
Important contra-indications noted in the Infection (viral) (9–19%)
prescribing guidelines for: nursing mothers; Synonyms: ursodeoxycholic acid; UDCA
pediatric patients Trade names: Actigall (Watson), Destolit
(Norgine), Urdox (Wockhardt), Urso 250 USTEKINUMAB
Mucosal (Aptalis), Urso Forte (Aptalis), Ursogal (Galen)
Indications: The dissolution of radiolucent (i.e. Trade name: Stelara (Centocor)
Oropharyngeal pain [2] Indications: Plaque psoriasis (moderate to
non-radio opaque) cholesterol gallstones in
Cardiovascular patients with a functioning gallbladder, primary severe), active psoriatic arthritis, active Crohn’s
Angina [2] biliary cirrhosis, biliary calculus, cholelithiasis disease (moderate to severe)
Arrhythmias [2] Class: Cholesterol antagonist, Urolithic Class: Interleukin-12/23 antagonist, Monoclonal
Extrasystoles [3] Half-life: 100 hours antibody
Hypertension [3] Half-life: 15–32 days
Supraventricular tachycardia [2] Clinically important, potentially hazardous
interactions with: aluminum based antacids,
Tachycardia [2] interactions with: live vaccines
aluminum hydroxide, charcoal, cholestyramine, Pregnancy category: B
Central Nervous System clofibrate, colestimide, colestipol, cyclosporine, Important contra-indications noted in the
Dysgeusia (taste perversion) [3] dapsone, estradiol, estrogens, nitrendipine, oral prescribing guidelines for: nursing mothers;
Headache [12] contraceptives, P4503A substrates pediatric patients
Arthralgia (2%) [2] Skin
Back pain [5] Cellulitis (<10%)
Gastrointestinal/Hepatic Herpes zoster [2]
Constipation [2] Malignancies [2]
Skin Pruritus (<10%)
Respiratory Lichenoid eruption [3] Psoriasis [3]
Bronchitis [2] Pruritus [3]
COPD (exacerbation) [5] Rash (3%)
Mucosal
Cough (3%) [6] Nasal congestion (<10%)
Dysphonia [4]
Hair Cardiovascular
Influenza [2] Alopecia (<5%)
Cardiotoxicity [3]
Nasopharyngitis (8%) [12] Cardiovascular Central Nervous System
Pharyngitis [2] Chest pain (3%) Depression (<10%)
Pneumonia [4] Central Nervous System Headache (<10%) [8]
Sinusitis [3] Headache (18–25%) Leukoencephalopathy [3]
Upper respiratory tract infection [5] Insomnia (2%) Vertigo (dizziness) (<10%)
Genitourinary Vertigo (dizziness) (17%) Neuromuscular/Skeletal
Urinary tract infection [2] Neuromuscular/Skeletal Arthralgia [3]
Other Arthralgia (7%) Asthenia (fatigue) (<10%) [2]
Adverse effects [4] Asthenia (fatigue) (3–7%) Back pain (<10%)
Back pain (7–12%) Myalgia/Myopathy (<10%)
Bone or joint pain (6%) Psoriatic arthralgia [2]
UNOPROSTONE Gastrointestinal/Hepatic
Gastrointestinal/Hepatic Diarrhea (<10%)
See: www.drugeruptiondata.com/drug/id/819 Abdominal pain (43%) Hepatotoxicity [2]
Cholecystitis (5%) Respiratory
Constipation (26%) Nasopharyngitis (10%) [9]
Diarrhea (27%) [4]
URACIL/TEGAFUR Dyspepsia (16%) [2]
Pharyngolaryngeal pain (<10%)
Flatulence (7%)
See: www.drugeruptiondata.com/drug/id/1118 Local
Nausea (14%) [4]
Vomiting (9–14%) [3]
Other
URAPIDIL Respiratory Adverse effects [11]
Bronchitis (6%)
Infection [12]
See: www.drugeruptiondata.com/drug/id/1302 Cough (7%)
VALACYCLOVIR Over 100 updates per week on www.drugeruptiondata.com
Nausea (2%) [2] tipranavir, vorinostat, zidovudine, zinc,

VALACYCLOVIR Vomiting (3%) zuclopenthixol
Genitourinary Pregnancy category: D
Trade name: Valtrex (GSK) Warning: LIFE THREATENING ADVERSE
Indications: Genital herpes, herpes simplex, Urinary retention (<5%)
Urinary tract infection [2] REACTIONS
herpes zoster
Class: Antiviral, Guanine nucleoside analog Ocular
Half-life: 3 hours Vision blurred (<5%) Skin
Clinically important, potentially hazardous Anticonvulsant hypersensitivity syndrome [6]
interactions with: cobicistat/elvitegravir/ DRESS syndrome [9]
Ecchymoses (<5%) [4]
emtricitabine/tenofovir alafenamide, cobicistat/
elvitegravir/emtricitabine/tenofovir disoproxil,
VALDECOXIB Edema [3]
immunosuppressants, meperidine, tenofovir Erythema multiforme [3]
See: www.drugeruptiondata.com/drug/id/902 Erythroderma [3]
disoproxil
Pregnancy category: B Exanthems (5%) [3]
Important contra-indications noted in the Facial edema (>5%)
prescribing guidelines for: the elderly; pediatric VALGANCICLOVIR Furunculosis (<5%)
patients Hypersensitivity [5]
Trade name: Valcyte (Roche) Lupus erythematosus [5]
Indications: Cytomegalovirus retinitis (CMV) in Peripheral edema (<5%)
Central Nervous System patients with AIDS, prevention of CMV disease in Petechiae (<5%)
Hallucinations [2] high-risk transplant patients Pruritus (>5%)
Headache [5] Class: Antiviral, Guanine nucleoside analog Pseudolymphoma [2]
Neurotoxicity [4] Half-life: 4 hours (in severe renal impairment up Purpura [2]
Gastrointestinal/Hepatic to 68%) Rash (>5%) [7]
Abdominal pain [2] Clinically important, potentially hazardous Stevens-Johnson syndrome [11]
Nausea [4] interactions with: abacavir, cobicistat/ Toxic epidermal necrolysis [7]
Vomiting [3] elvitegravir/emtricitabine/tenofovir alafenamide, Vasculitis [3]
Renal cobicistat/elvitegravir/emtricitabine/tenofovir Hair
Nephrotoxicity [2] disoproxil, emtricitabine, tenofovir disoproxil Alopecia (7%) [22]
Pregnancy category: N/A (May cause fetal Curly hair [6]
toxicity based on findings in animal studies) Hirsutism [2]
VALBENAZINE * prescribing guidelines for: nursing mothers Nails
Note: Valganciclovir is rapidly converted to Nail pigmentation [2]
Trade name: Ingrezza (Neurocrine Biosciences) ganciclovir in the body. Mucosal
Indications: Tardive dyskinesia Warning: HEMATOLOGIC TOXICITY, Gingival hyperplasia/hypertrophy [8]
Class: Vesicular monoamine transporter 2 IMPAIRMENT OF FERTILITY, FETAL TOXICITY, Glossitis (<5%)
inhibitor MUTAGENESIS AND CARCINOGENESIS Stomatitis (<5%)
Half-life: 15–22 hours Xerostomia (<5%) [2]
interactions with: carbamazepine, Mucosal Central Nervous System
clarithromycin, digoxin, fluoxetine, isocarboxazid, Oral candidiasis [2] Brain atrophy [2]
itraconazole, ketoconazole, MAO inhibitors, Central Nervous System Cerebral edema [2]
paroxetine hydrochloride, phenelzine, phenytoin, Fever [3] Cognitive impairment [2]
quinidine, rifampin, selegiline, St John’s wort, Headache [2] Coma [3]
strong CYP2D6 inducers, strong CYP3A4 Neurotoxicity [2] Confusion [2]
inducers or inhibitors Paresthesias (8%) Delirium [2]
Pregnancy category: N/A (May cause fetal Dysgeusia (taste perversion) (<5%)
Hematologic Encephalopathy [17]
harm) Neutropenia [8]
Important contra-indications noted in the Gait instability [2]
prescribing guidelines for: nursing mothers; Other Headache [2]
pediatric patients Allergic reactions (<5%) Neurotoxicity [4]
Infection (<5%) Paresthesias (<5%)
Parkinsonism [15]
Mucosal Sedation [3]
Xerostomia (<5%) Seizures [10]
VALPROIC ACID Somnolence (drowsiness) [11]
Akathisia (<3%) Synonyms: valproate sodium; divalproex Tremor [14]
Gait instability (<4%) Trade names: Depacon (AbbVie), Depakene Vertigo (dizziness) [7]
Headache (3%) [4] (AbbVie), Depakote (AbbVie) Neuromuscular/Skeletal
Impaired concentration (<5%) Indications: Seizures, migraine Asthenia (fatigue) [4]
Restlessness (<3%) Class: Anticonvulsant, Antipsychotic Osteoporosis [3]
Sedation (<11%) Half-life: 616 hours Rhabdomyolysis [3]
Somnolence (drowsiness) (<11%) [4] Clinically important, potentially hazardous
Vertigo (dizziness) (<4%) Gastrointestinal/Hepatic
interactions with: amitriptyline, aspirin, Constipation [2]
Neuromuscular/Skeletal ceftobiprole, cholestyramine, clobazam, Dyspepsia [2]
Arthralgia (2%) clozapine, doripenem, eslicarbazepine, Hepatic steatosis [2]
Asthenia (fatigue) (<11%) [5] ethosuximide, indinavir, ivermectin, lesinurad, Hepatotoxicity [19]
Gastrointestinal/Hepatic levomepromazine, meropenem & vaborbactam, Nausea [4]
Constipation (<5%) [2] olanzapine, oxcarbazepine, paliperidone, Pancreatitis [32]
risperidone, rufinamide, temozolomide,
Litt’s Drug Eruption & Reaction Manual VANDETANIB
Vomiting [2] Warning: FETAL TOXICITY Red man syndrome (<14%) [50]
Respiratory Red neck syndrome [2]
Pleural effusion [3] Skin Stevens-Johnson syndrome [10]
Pneumonitis [2] Angioedema (>2%) [9] Toxic epidermal necrolysis [10]
Edema [5] Urticaria [8]
Endocrine/Metabolic Vasculitis [2]
Acute intermittent porphyria [2] Peripheral edema [3]
Appetite increased [2] Photosensitivity [2] Cardiovascular
Hyperammonemia [13] Pruritus (>2%) Cardiac arrest [2]
Hyponatremia [2] Pseudolymphoma [2] Extravasation [2]
Metabolic syndrome [3] Rash (>2%) Flushing (<10%)
Porphyria [2] Mucosal Hypotension [3]
SIADH [6] Aphthous stomatitis (<10%) Phlebitis (1423%) [6]
Weight gain [23] Xerostomia (>10%) Central Nervous System
Genitourinary Cardiovascular Chills (>10%) [2]
Vaginitis (<5%) Hypotension [2] Dysgeusia (taste perversion) (>10%)
Fever [7]
Renal Central Nervous System Headache [4]
Enuresis [2] Dysgeusia (taste perversion) (>10%) Vertigo (dizziness) [2]
Fanconi syndrome [4] Headache [7]
Paresthesias (>2%) Gastrointestinal/Hepatic
Hematologic Constipation [3]
Bone marrow suppression [4] Vertigo (dizziness) [9]
Diarrhea [7]
Coagulopathy [2] Neuromuscular/Skeletal Gastrointestinal disorder [2]
Eosinophilia [2] Arthralgia (<10%) Nausea [11]
Hemotoxicity [3] Myalgia/Myopathy (1029%) Vomiting [5]
Neutropenia [3] Gastrointestinal/Hepatic
Thrombocytopenia [4] Endocrine/Metabolic
Enteropathy [2] ALT increased [2]
Otic Respiratory AST increased [2]
Hearing loss [2] Cough [2] Renal
Ocular Nasopharyngitis [3] Nephrotoxicity [32]
Ocular adverse effects [2] Upper respiratory tract infection [2] Renal failure [3]
Other Endocrine/Metabolic Hematologic
Adverse effects [8] Hyperkalemia [3] Anemia [2]
Allergic reactions (<5%) Other Eosinophilia [3]
Congenital malformations [4] Adverse effects [5] Leukopenia [2]
Death [8] Allergic reactions (>2%) Neutropenia [7]
Teratogenicity [31] Thrombocytopenia [16]
Otic
VALRUBICIN VANCOMYCIN Ototoxicity [5]
Tinnitus [2]
Trade name: Vancocin (Lilly) Local
See: www.drugeruptiondata.com/drug/id/964 Indications: Various infections caused by Infusion-related reactions [2]
Class: Antibiotic, glycopeptide Other
VALSARTAN Half-life: 511 hours Adverse effects [5]
Allergic reactions (<5%) [5]
Trade names: Byvalson (Forest), Diovan interactions with: meloxicam, metformin, Death [5]
(Novartis), Diovan HCT (Novartis), Exforge pentamidine, rocuronium, succinylcholine,
(Novartis), Valturna (Novartis) teicoplanin, trospium
Indications: Hypertension Pregnancy category: C VANDETANIB
Class: Angiotensin II receptor antagonist
(blocker), Antihypertensive Skin Trade name: Caprelsa (AstraZeneca)
Half-life: 9 hours Abscess [2] Indications: Medullary thyroid cancer
Clinically important, potentially hazardous AGEP [8] Class: Tyrosine kinase inhibitor
interactions with: none known Anaphylactoid reactions/Anaphylaxis [14] Half-life: 19 days
Pregnancy category: D Angioedema [3] Clinically important, potentially hazardous
Important contra-indications noted in the Bullous dermatitis [5] interactions with: amiodarone, amoxapine,
prescribing guidelines for: nursing mothers; Cellulitis [3] antiarrhythmics, arsenic, carbamazepine,
pediatric patients DRESS syndrome [18] chloroquine, clarithromycin, CYP3A4 inducers,
Note: Byvalson is valsartan and nebivolol; Erythema multiforme [5] dexamethasone, disopyramide, dofetilide,
Exforge is valsartan and amlodipine; Valturna is Exanthems [16] dolasetron, efavirenz, granisetron, haloperidol,
valsartan and aliskiren; Diovan HCT is valsartan Exfoliative dermatitis [4] methadone, moxifloxacin, pazopanib,
and hydrochlorothiazide. Hydrochlorothiazide is Fixed eruption [2] phenobarbital, phenytoin, pimozide,
a sulfonamide and can be absorbed systemically. Hypersensitivity [8] procainamide, QT prolonging agents, rifabutin,
Sulfonamides can produce severe, possibly fatal, Leukocytoclastic vasculitis [4] rifampin, rifapentine, sotalol, St John’s wort,
reactions such as toxic epidermal necrolysis and Linear IgA bullous dermatosis [50] telavancin
Stevens-Johnson syndrome. Lupus erythematosus [2]
See also separate profile for Sacubitril/Valsartan. Pruritus [12]
Rash [19]
VANDETANIB See all our books at www.crcpress.com
Pregnancy category: D Platelets decreased (9%) Neuromuscular/Skeletal

Important contra-indications noted in the Other Arthralgia (<2%)
prescribing guidelines for: nursing mothers; Adverse effects [6] Back pain (<2%)
pediatric patients Death [3] Cramps (<2%)
Note: Contra-indicated in patients with Myalgia/Myopathy (<2%)
congenital long QT syndrome. Gastrointestinal/Hepatic
Warning: QT PROLONGATION, TORSADES
DE POINTES, AND SUDDEN DEATH VARDENAFIL Abdominal pain (<2%)
Diarrhea (<2%)
Trade name: Levitra (Bayer) Dyspepsia [3]
Skin Indications: Erectile dysfunction Gastritis (<2%)
Acneform eruption (35%) [4] Class: Phosphodiesterase type 5 (PDE5) inhibitor Gastroesophageal reflux (<2%)
Folliculitis [5] Half-life: 45 hours Nausea (<2%)
Hand–foot syndrome [4] Clinically important, potentially hazardous Vomiting (<2%)
Photosensitivity (13%) [8] interactions with: alfuzosin, alpha blockers, Respiratory
Phototoxicity [3] amyl nitrite, antifungals, antihypertensives, Dyspnea (<2%)
Pigmentation [6] atazanavir, boceprevir, bosentan, cobicistat/ Flu-like syndrome (3%)
Pruritus (11%) [2] elvitegravir/emtricitabine/tenofovir alafenamide, Rhinitis (9%) [10]
Rash (53%) [34] cobicistat/elvitegravir/emtricitabine/tenofovir Sinusitis (3%)
Stevens-Johnson syndrome [2] disoproxil, conivaptan, CYP3A4 inhibitors,
Toxicity [9] Endocrine/Metabolic
darunavir, dasatinib, disopyramide, doxazosin,
Xerosis (15%) [3] ALT increased (<2%)
erythromycin, etravirine, fosamprenavir,
Creatine phosphokinase increased (<2%)
Hair grapefruit juice, high-fat foods, indinavir,
Hair changes [2] itraconazole, ketoconazole, lopinavir, macrolide Genitourinary
antibiotics, nelfinavir, nicorandil, nifedipine, Erection (<2%)
Nails Priapism (<2%)
Paronychia [5] nitrates, nitroglycerin, nitroprusside,
Splinter hemorrhage [2] phosphodiesterase 5 inhibitors, protease Otic
inhibitors, riociguat, ritonavir, sapropterin, Hearing loss [2]
Mucosal saquinavir, tamsulosin, telaprevir, terazosin, Tinnitus (<2%)
Mucositis [2] tipranavir
Stomatitis [2] Ocular
Pregnancy category: B (not indicated for use in
Conjunctivitis (<2%)
Cardiovascular women)
Dyschromatopsia (<2%)
Hypertension (33%) [24] Important contra-indications noted in the
Intraocular pressure increased (<2%)
QT prolongation (14%) [25] prescribing guidelines for: pediatric patients
Ocular hyperemia (<2%)
Central Nervous System Ocular pain (<2%)
Anorexia [3] Skin Photophobia (<2%)
Depression (10%) Anaphylactoid reactions/Anaphylaxis (<2%) Visual disturbances (<2%)
Headache (26%) [4] Angioedema (<2%)
Other
Insomnia (13%) Diaphoresis (<2%)
Allergic reactions (<2%)
Neurotoxicity [2] Erythema (<2%)
Neuromuscular/Skeletal Facial edema (<2%)
Asthenia (fatigue) (15–24%) [17] Photosensitivity (<2%)
Pruritus (<2%) VARENICLINE
Gastrointestinal/Hepatic Rash (<2%)
Abdominal pain (21%) Trade names: Champix (Pfizer), Chantix (Pfizer)
Constipation [2] Mucosal
Indications: Smoking deterrent
Diarrhea (57%) [44] Nasal congestion [4]
Class: Nicotinic antagonist
Dyspepsia (11%) Xerostomia (<2%)
Half-life: 24 hours
Hepatotoxicity [4] Cardiovascular Clinically important, potentially hazardous
Nausea (33%) [14] Angina (<2%) interactions with: none known
Vomiting (15%) [6] Chest pain (<2%) Pregnancy category: C
Respiratory Flushing (11%) [14] Important contra-indications noted in the
Cough (11%) Hypotension (<2%) prescribing guidelines for: nursing mothers;
Dyspnea [3] Myocardial infarction (<2%) pediatric patients
Nasopharyngitis (11%) Palpitation (<2%) Warning: SERIOUS NEUROPSYCHIATRIC
QT prolongation [2] EVENTS
Endocrine/Metabolic Tachycardia (<2%)
ALT increased (51%) [2] Ventricular arrhythmia (<2%)
Appetite decreased (21%) [3] Skin
Hypocalcemia (11%) Central Nervous System AGEP [3]
Hypothyroidism [2] Amnesia (<2%) Rash (<3%)
Thyroid dysfunction [2] Dysesthesia (<2%)
Mucosal
Weight loss (10%) [2] Headache (715%) [16]
Xerostomia (4–6%)
Pain (<2%)
Renal Paresthesias (<2%) Cardiovascular
Proteinuria (10%) [2] Seizures (<2%) Cardiotoxicity [5]
Hematologic Sleep related disorder (<2%) Central Nervous System
Anemia [3] Somnolence (drowsiness) (<2%) Abnormal dreams (9–13%) [16]
Hemorrhage [2] Syncope (<2%) Aggression [3]
Hemotoxicity [2] Vertigo (dizziness) (2%) [3] Anorexia (<2%)
Myelosuppression [2] Anxiety [5]
Neutropenia [5] Depression [9]
Litt’s Drug Eruption & Reaction Manual VEMURAFENIB
Dysgeusia (taste perversion) (5–8%) Pain in extremities (3%)

Hallucinations [2] VASOPRESSIN Gastrointestinal/Hepatic
Headache (15–19%) [12] Abdominal pain [7]
Insomnia (18–19%) [15] Trade name: Vasostrict (Par)
Indications: Diabetes insipidus, prevention and Colitis [5]
Mania [5] Crohn’s disease (exacerbation) [2]
Mood changes [4] treatment of postoperative abdominal distension,
hypotension in adults with vasodilatory shock Nausea (9%) [9]
Neuropsychiatric disturbances [2] Vomiting [4]
Nightmares (<2%) (Vasostrict)
Psychosis [7] Class: Antidiuretic hormone Respiratory
Sleep disturbances [7] Half-life: 1020 minutes Bronchitis (4%)
Sleep related disorder (2–5%) [3] Clinically important, potentially hazardous Cough (5%) [3]
Somnolence (drowsiness) (3%) [2] interactions with: none known Influenza (4%)
Suicidal ideation [7] Pregnancy category: C Nasopharyngitis (13%) [11]
Important contra-indications noted in the Sinusitis (3%)
Neuromuscular/Skeletal prescribing guidelines for: pediatric patients Upper respiratory tract infection (7%) [7]
Hematologic
Gastrointestinal/Hepatic Skin Anemia [4]
Abdominal pain (5–7%) [3] Bullous dermatitis [4]
Constipation (5–8%) [4] Local
Diaphoresis (<10%) Infusion-related reactions (4%) [4]
Dyspepsia (5%) [2] Ecchymoses [2]
Flatulence (6–9%) Pallor (<10%) Other
Hepatotoxicity [2] Purpura [2] Adverse effects [7]
Nausea (16–30%) [28] Urticaria (<10%) Cancer [2]
Vomiting (<5%) [2] Infection [5]
Respiratory Tremor (<10%)
Dyspnea (<2%)
Upper respiratory tract infection (5–7%) Neuromuscular/Skeletal VELAGLUCERASE ALFA
Rhabdomyolysis [6]
Endocrine/Metabolic
Appetite decreased (<2%) Endocrine/Metabolic See: www.drugeruptiondata.com/drug/id/1651
Appetite increased (3–4%) SIADH [2]
Ocular Local
Hallucinations, visual [2] Injection-site inflammation [7] VEMURAFENIB
Other Other
Death [3] Trade name: Zelboraf (Roche)
Adverse effects [10] Indications: Melanoma (metastatic or
Death [3] unresectable)
Class: BRAF inhibitor
VECURONIUM Half-life: 57 hours
VARICELLA VACCINE See: www.drugeruptiondata.com/drug/id/991
interactions with: amoxapine, arsenic,
Trade names: Varilrix (GSK), Varivax (Merck) atazanavir, carbamazepine, clarithromycin, CYP
Indications: Immunization, varicella substrates, dolasetron, efavirenz, indinavir,
Class: Vaccine VEDOLIZUMAB itraconazole, ketoconazole, nefazodone,
Half-life: N/A nelfinavir, pazopanib, phenobarbital, phenytoin,
Clinically important, potentially hazardous Trade name: Entyvio (Takeda) rifabutin, rifampin, rifapentine, ritonavir,
interactions with: none known Indications: Ulcerative colitis, Crohn’s disease saquinavir, telavancin, telithromycin,
Pregnancy category: C Class: Integrin receptor antagonist, Monoclonal voriconazole, warfarin
antibody Pregnancy category: D
Skin Half-life: 25 days Important contra-indications noted in the
Herpes zoster [10] Clinically important, potentially hazardous prescribing guidelines for: nursing mothers;
Rash [10] interactions with: live vaccines, natalizumab, pediatric patients
Stevens-Johnson syndrome [2] TNF blockers
Pregnancy category: B Skin
Fever (15%) [3] Acneform eruption [6]
prescribing guidelines for: nursing mothers; Actinic keratoses [4]
Ocular pediatric patients DRESS syndrome [4]
Uveitis [2] Eccrine squamous syringometaplasia [2]
Local Skin Erythema (14%) [2]
Injection-site edema (19%) Pruritus (3%) Exanthems [8]
Injection-site erythema (19%) Rash (3%) [2] Granulomas [2]
Injection-site hematoma (19%) Mucosal Grover’s disease [4]
Injection-site induration (19%) Oropharyngeal pain (3%) Hand–foot syndrome [8]
Injection-site pain (19%) Hyperkeratosis (24%) [17]
Injection-site pruritus (19%) Central Nervous System Keratoacanthoma [27]
Injection-site reactions [4] Fever (9%) [5] Keratoses [4]
Headache (12%) [11] Keratosis pilaris [10]
Neuromuscular/Skeletal Lymphoma [2]
Arthralgia (12%) [8] Melanoma [2]
Asthenia (fatigue) (6%) [6] Milia [2]
Back pain (4%) [3] Neoplasms [2]
VEMURAFENIB Over 100 updates per week on www.drugeruptiondata.com
Nevi [6]
Panniculitis [9] VENETOCLAX VENLAFAXINE
Papillomas (21%)
Papular lesions (5%) Trade name: Venclexta (AbbVie) Trade names: Effexor (Wyeth), Effexor XL
Peripheral edema (17%) Indications: Chronic lymphocytic leukemia in (Wyeth)
Photosensitivity (33%) [27] patients with 17p deletion, as detected by an FDA Indications: Major depressive disorder
Pruritus (23%) [10] approved test, who have received at least one Class: Antidepressant, Serotonin-norepinephrine
Radiation recall dermatitis [2] prior therapy reuptake inhibitor
Rash (37%) [23] Class: BCL-2 inhibitor Half-life: 37 hours
Squamous cell carcinoma (24%) [35] Half-life: 26 hours Clinically important, potentially hazardous
Stevens-Johnson syndrome [4] Clinically important, potentially hazardous interactions with: 5HT1 agonists, artemether/
Sunburn (10%) interactions with: amiodarone, azithromycin, lumefantrine, aspirin, atomoxetine, clozapine,
Toxic epidermal necrolysis [5] bosentan, captopril, carbamazepine, carvedilol, desvenlafaxine, dexibuprofen, diclofenac,
Toxicity [10] ciprofloxacin, clarithromycin, conivaptan, duloxetine, entacapone, haloperidol, indinavir,
Vasculitis [2] cyclosporine, digoxin, diltiazem, dronedarone, isocarboxazid, ketoconazole, linezolid, lithium,
Verruca vulgaris [2] efavirenz, erythromycin, etravirine, everolimus, MAO inhibitors, meloxicam, metoclopramide,
Verrucous lesions [3] felodipine, fluconazole, grapefruit juice, indinavir, metoprolol, mirtazapine, moclobemide,
Vitiligo [2] itraconazole, ketoconazole, live vaccines, naratriptan, NSAIDs, phenelzine, selegiline,
Warts [2] lopinavir, modafinil, nafcillin, phenytoin, sibutramine, SNRIs, SSRIs, St John’s wort,
Xerosis [5] posaconazole, quercetin, quinidine, ranolazine, sumatriptan, tramadol, tranylcypromine,
rifampin, ritonavir, sirolimus, St John’s wort, stong trazodone, trimipramine, triptans, voriconazole,
Hair or moderate P-gp inhibitors or substrates, strong warfarin
Alopecia (45%) [18] or moderate CYP3A inducers or inhibitors, Pregnancy category: C
Hair changes [2] telaprevir, ticagrelor, verapamil, voriconazole Important contra-indications noted in the
Nails Pregnancy category: N/A (May cause fetal prescribing guidelines for: the elderly; nursing
Paronychia [3] harm) mothers; pediatric patients
Pyogenic granuloma [2] Important contra-indications noted in the Warning: SUICIDALITY AND
Mucosal prescribing guidelines for: nursing mothers; ANTIDEPRESSANT DRUGS
Gingival hyperplasia/hypertrophy [2] pediatric patients
Note: Concomitant use of strong CYP3A Skin
Cardiovascular inhibitors during initiation and ramp-up phase is
QT prolongation [2] Diaphoresis [7]
contra-indicated. Ecchymoses [2]
Central Nervous System Hyperhidrosis [2]
Dysgeusia (taste perversion) (14%) Skin Pruritus (<10%)
Fever (19%) [5] Peripheral edema (11%) Rash (3%)
Headache (23%) [2] Tumor lysis syndrome (6%) [7]
Paralysis [2] Hair
Central Nervous System Alopecia [2]
Neuromuscular/Skeletal Fever (16%) [3]
Arthralgia (53%) [19] Mucosal
Headache (15%) [2] Xerostomia (22%) [10]
Back pain (8%) Neuromuscular/Skeletal Cardiovascular
Bone or joint pain (8%) Asthenia (fatigue) (21%) [3] Cardiac failure [2]
Myalgia/Myopathy (8–13%) [2] Back pain (10%) Cardiomyopathy [3]
Pain in extremities (18%) Gastrointestinal/Hepatic Hypertension [7]
Gastrointestinal/Hepatic Constipation (14%) Myocardial infarction [2]
Constipation (12%) Diarrhea (35%) [5] Orthostatic hypotension [2]
Diarrhea (28%) [7] Nausea (33%) [6] Preeclampsia [2]
Hepatotoxicity [4] Vomiting (15%) QT prolongation [6]
Nausea (35%) [8] Respiratory Tachycardia [2]
Vomiting (18%) [3] Cough (13%) Central Nervous System
Respiratory Pneumonia (8%) [3] Akathisia [2]
Cough (8%) Upper respiratory tract infection (22%) [3] Delirium [2]
Endocrine/Metabolic Dysgeusia (taste perversion) (2%)
Endocrine/Metabolic Headache [8]
ALT increased [5] Hyperkalemia (20%)
Hyperphosphatemia (15%) Insomnia [5]
Appetite decreased (18%) [2] Mania [10]
AST increased [5] Hyperuricemia (6%)
Hypocalcemia (9%) Paresthesias (3%)
GGT increased [2] Psychosis [3]
Hypokalemia (12%)
Ocular Restless legs syndrome [3]
Chorioretinopathy [2] Hematologic Seizures [7]
Uveitis [3] Anemia (29%) [5] Serotonin syndrome [22]
Vision blurred [2] Febrile neutropenia [3] Somnolence (drowsiness) [9]
Neutropenia (45%) [7] Tremor (<10%) [3]
Other Thrombocytopenia (22%) [5]
Adverse effects [11] Vertigo (dizziness) [10]
Other Yawning [2]
Death [3] Neuromuscular/Skeletal
Dystonia [2]
Rhabdomyolysis [3]
Litt’s Drug Eruption & Reaction Manual VIGABATRIN
Gastrointestinal/Hepatic Exfoliative dermatitis [2] Neuromuscular/Skeletal

Constipation [6] Hyperkeratosis (palms) [2] Arthralgia (<10%)
Hepatotoxicity [8] Lupus erythematosus [2] Asthenia (fatigue) (<10%)
Nausea [16] Peripheral edema (<10%) Back pain (<10%)
Vomiting [3] Photosensitivity [4] Myasthenia gravis (<10%)
Respiratory Pruritus [6] Gastrointestinal/Hepatic
Pneumonitis [3] Rash [2] Constipation (<10%)
Stevens-Johnson syndrome [5] Nausea (<10%)
Endocrine/Metabolic Urticaria [5]
Appetite decreased [2] Vasculitis [2] Respiratory
Galactorrhea [4] Flu-like syndrome (<10%)
Hyponatremia [4] Hair Pharyngitis (<10%)
Libido increased [2] Alopecia [5]
Endocrine/Metabolic
Mastodynia [2] Mucosal Creatine phosphokinase increased (<10%)
SIADH [6] Gingival hyperplasia/hypertrophy (19%) [10]
Weight gain [2] Genitourinary
Cardiovascular Albuminuria (<10%)
Genitourinary Atrial fibrillation [2]
Ejaculatory dysfunction [2] Atrioventricular block [2] Hematologic
Sexual dysfunction [8] Bradycardia [10] Anemia (<10%)
Urinary incontinence [2] Congestive heart failure [2] Leukocytosis (<10%)
Flushing (<7%) [4] Leukopenia (<10%)
Ocular
Glaucoma [2] Hypotension [2] Otic
Hallucinations, visual [3] Torsades de pointes [2] Hearing loss (<10%)
Other Central Nervous System Ocular
Adverse effects [3] Parkinsonism [2] Blepharitis (<10%)
Bruxism [7] Seizures [3] Cataract (<10%)
Neuromuscular/Skeletal Conjunctivitis (<10%)
Rhabdomyolysis [2] Diplopia (<10%)
Endophthalmitis [2]
VERAPAMIL Endocrine/Metabolic Intraocular inflammation [2]
Gynecomastia [8] Lacrimation (<10%)
Trade names: Calan (Pfizer), Covera-HS Other Ocular itching (<10%)
(Pfizer), Isoptin (AbbVie), Tarka (AbbVie), Verelan Side effects [2] Vision loss (severe) (<5%)
(Schwarz) Visual disturbances (10–30%)
Indications: Angina, arrhythmias, hypertension Xerophthalmia (<10%)
Class: Antiarrhythmic class IV, Calcium channel
blocker, CYP3A4 inhibitor VERNAKALANT Local
Half-life: 28 hours Infusion-site pain (<10%)
Clinically important, potentially hazardous See: www.drugeruptiondata.com/drug/id/1406 Injection-site reactions (10–30%)
interactions with: acebutolol, afatinib, aliskiren, Other
amiodarone, amitriptyline, amprenavir, aspirin, Cancer (gastrointestinal) (<10%)
atazanavir, atenolol, atorvastatin, avanafil, VERTEPORFIN
betaxolol, betrixaban, bisoprolol, carbamazepine,
carteolol, celiprolol, clonidine, cobicistat/ Trade name: Visudyne (Novartis)
elvitegravir/emtricitabine/tenofovir alafenamide, Indications: Neovascular (wet) age-related
VIDARABINE
cobicistat/elvitegravir/emtricitabine/tenofovir macular degeneration
disoproxil, colchicine, dabigatran, dantrolene, Class: Photosensitizer
darifenacin, deflazacort, delavirdine, digoxin, Half-life: 56 hours
dofetilide, dronedarone, dutasteride, epirubicin, Clinically important, potentially hazardous
eplerenone, erythromycin, esmolol, everolimus, interactions with: none known VIGABATRIN
fingolimod, flibanserin, indacaterol, lovastatin, Pregnancy category: C
metoprolol, mifepristone, nadolol, naldemedine, Important contra-indications noted in the Trade name: Sabril (Lundbeck)
naloxegol, neratinib, nevirapine, olaparib, prescribing guidelines for: nursing mothers; Indications: Epilepsy, infantile spasms (West’s
oxprenolol, oxtriphylline, palbociclib, penbutolol, pediatric patients syndrome)
pindolol, posaconazole, propranolol, quinidine, Class: Anticonvulsant, Antiepileptic
ranolazine, sibutramine, silodosin, simvastatin, Half-life: 7.5 hours
telaprevir, telithromycin, timolol, trabectedin, Eczema (<10%)
venetoclax interactions with: antipsychotics, chloroquine,
Photosensitivity (<10%) [2] hydroxychloroquine, MAO inhibitors, mefloquine,
Important contra-indications noted in the Mucosal orlistat, phenytoin, rufinamide, SSRIs, St John’s
prescribing guidelines for: nursing mothers; Burning mouth syndrome (<10%) wort, tricyclic antidepressants
pediatric patients Cardiovascular Pregnancy category: C
Note: Tarka is verapamil and trandolapril. Atrial fibrillation (<10%) Important contra-indications noted in the
Chest pain [2] prescribing guidelines for: nursing mothers;
Hypertension (<10%) pediatric patients
Skin Warning: VISION LOSS
Angioedema [3] Central Nervous System
Diaphoresis [2] Fever (<10%)
Edema (2%) Hypoesthesia (<10%) Skin
Erythema multiforme [4] Sleep related disorder (<10%) Peripheral edema (5–7%)
Exanthems [8] Vertigo (dizziness) (<10%) Rash (6%) [2]
VIGABATRIN See all our books at www.crcpress.com
Cardiovascular Vision impaired [20]

Chest pain (<5%) Other
VINBLASTINE
Central Nervous System Adverse effects [3] Trade names: Velban (Lilly), Velbe (Lilly), Velsar
Abnormal dreams (<5%) Dipsia (thirst) (2%) (Lilly)
Anxiety (4%) Toothache (2–5%) Indications: Lymphomas, melanoma, carcinomas
Confusion (4–14%) Class: Antimitotic, Vinca alkaloid
Depression (8%) [4] Half-life: initial: 3.7 minutes; terminal: 24.8 hours
Dysarthria (2%)
Encephalopathy [4]
VILAZODONE Clinically important, potentially hazardous
interactions with: aldesleukin, aprepitant,
Fever (4–7%) Trade name: Viibryd (Merck KGaA) erythromycin, fluconazole, itraconazole,
Gait instability (6–12%) Indications: Major depressive disorder ketoconazole, lopinavir, miconazole,
Headache (18%) Class: Antidepressant, Serotonin-norepinephrine posaconazole
Hypoesthesia (4–5%) reuptake inhibitor Pregnancy category: D
Hyporeflexia (4–5%) Half-life: 25 hours Important contra-indications noted in the
Impaired concentration (9%) Clinically important, potentially hazardous prescribing guidelines for: nursing mothers
Incoordination (7%) interactions with: anticoagulants, aspirin,
Insomnia (7%) buspirone, CNS-active agents, CYP3A4 inhibitors
Irritability (7%) Skin
or inducers, efavirenz, erythromycin, Acral necrosis [2]
Memory loss (7%) ketoconazole, MAO inhibitors, NSAIDs, SNRIs,
Nervousness (2–5%) Dermatitis (<10%)
SSRIs, tramadol, triptans, tryptophan, warfarin Photosensitivity (<10%) [2]
Peripheral neuropathy (4%) Pregnancy category: C
Psychosis [2] Pigmentation [3]
Important contra-indications noted in the Radiation recall dermatitis [2]
Sedation (4%) prescribing guidelines for: nursing mothers;
Seizures (11%) [4] Rash (<10%)
pediatric patients Raynaud’s phenomenon (<10%) [17]
Somnolence (drowsiness) (17%) [3] Warning: SUICIDALITY AND
Status epilepticus (2–5%) ANTIDEPRESSANT DRUGS Hair
Tremor (7%) Alopecia (>10%)
Vertigo (dizziness) (15%) Mucosal
Mucosal
Neuromuscular/Skeletal Xerostomia (8%) Mucositis [2]
Arthralgia (5–10%) Oral lesions (<5%)
Asthenia (fatigue) (16%) [2] Cardiovascular Stomatitis (>10%)
Back pain (4–7%) Palpitation (2%)
Muscle spasm (3%) Central Nervous System Dysgeusia (taste perversion) (metallic taste)
Myalgia/Myopathy (3–5%) Abnormal dreams (4%) (>10%)
Pain in extremities (2–6%) Headache [3] Paresthesias (<10%)
Gastrointestinal/Hepatic Insomnia (6%) [4]
Paresthesias (3%) Neuromuscular/Skeletal
Abdominal distension (2%) Myalgia/Myopathy (<10%)
Abdominal pain (2–3%) Restlessness (3%)
Constipation (5–8%) Somnolence (drowsiness) (3%) [2] Endocrine/Metabolic
Diarrhea (7%) Tremor (2%) SIADH [4]
Dyspepsia (4–5%) Vertigo (dizziness) (9%) [2] Renal
Nausea (7%) Neuromuscular/Skeletal Nephrotoxicity [2]
Vomiting (6%) Arthralgia (3%) Hematologic
Respiratory Asthenia (fatigue) (4%)
Hemolytic uremic syndrome [2]
Bronchitis (5%) Gastrointestinal/Hepatic Neutropenia [2]
Cough (2–14%) Diarrhea (28%) [14] Otic
Influenza (5–7%) Dyspepsia (3%)
Tinnitus [2]
Nasopharyngitis (10%) Flatulence (3%)
Pharyngolaryngeal pain (7–14%) Gastroenteritis (3%) Local
Upper respiratory tract infection (10%) Nausea (23%) [14] Injection-site necrosis [2]
Endocrine/Metabolic Vomiting (5%) [4] Other
Appetite increased (<5%) Endocrine/Metabolic Adverse effects [2]
Weight gain (10%) [4] Appetite increased (2%)
Genitourinary Libido decreased (4–5%)
Dysmenorrhea (5–9%) Genitourinary VINCRISTINE
Erectile dysfunction (5%) Ejaculatory dysfunction (2%)
Urinary tract infection (4–5%) Erectile dysfunction (2%) Synonym: oncovin
Sexual dysfunction (3%) [2] Trade name: Vincasar (Teva)
Hematologic Indications: Leukemias, lymphomas,
Anemia (6%) Other neuroblastoma, Wilm’s tumor
Otic Adverse effects [3] Class: Antimitotic, Vinca alkaloid
Tinnitus (2%) Half-life: 24 hours
Diplopia (6%) VILDAGLIPTIN interactions with: aldesleukin, aprepitant,
Nystagmus (7%) bromelain, fluconazole, gadobenate, influenza
Ocular pain (5%) See: www.drugeruptiondata.com/drug/id/1338 vaccine, itraconazole, ketoconazole, lopinavir,
Optic atrophy [2] miconazole, nifedipine, posaconazole,
Retinopathy [12] thalidomide
Vision blurred (6%)
Litt’s Drug Eruption & Reaction Manual VITAMIN A
Pregnancy category: D Pregnancy category: D Pregnancy category: D

Important contra-indications noted in the Important contra-indications noted in the Important contra-indications noted in the
prescribing guidelines for: nursing mothers prescribing guidelines for: nursing mothers; prescribing guidelines for: nursing mothers;
pediatric patients pediatric patients
Skin Warning: MYELOSUPPRESSION Note: Patients should not donate blood or blood
Erythroderma [2] products while receiving vismodegib and for at
Exanthems [3] Skin least 7 months after the last dose.
Hand–foot syndrome [2] Acneform eruption [3] Warning: EMBRYO-FETAL TOXICITY
Rash (<10%) Hand–foot syndrome [7]
Raynaud’s phenomenon [2] Rash (<5%) [2] Skin
Hair Recall reaction [2] Squamous cell carcinoma [2]
Alopecia (2070%) [9] Hair Toxicity [2]
Nails Alopecia (12%) [5] Hair
Beau’s lines (transverse nail bands) [2] Mucosal Alopecia (64%) [22]
Leukonychia (Mees’ lines) [5] Mucositis [2] Central Nervous System
Mucosal Stomatitis (>10%) [6] Ageusia (taste loss) (11%) [6]
Oral lesions (<10%) [2] Cardiovascular Anorexia [2]
Oral ulceration (<10%) Extravasation [2] Dysgeusia (taste perversion) (55%) [19]
Cardiovascular Hypertension [2] Neuromuscular/Skeletal
Hypertension [2] Phlebitis (7%) Arthralgia (16%) [2]
Phlebitis (<10%) Central Nervous System Asthenia (fatigue) (40%) [15]
Anorexia [7] Muscle spasm (72%) [19]
Central Nervous System Myalgia/Myopathy [5]
Anorexia [2] Dysgeusia (taste perversion) (metallic taste)
Dysgeusia (taste perversion) (<10%) (>10%) Gastrointestinal/Hepatic
Neurotoxicity [16] Hyperesthesia (<10%) Constipation (21%)
Paresthesias (<10%) Neurotoxicity [4] Diarrhea (29%) [7]
Peripheral neuropathy [10] Paresthesias (<10%) Hepatotoxicity [3]
Seizures [6] Neuromuscular/Skeletal Nausea (30%) [7]
Asthenia (fatigue) [14] Vomiting (14%) [2]
Asthenia (fatigue) [2] Bone or joint pain [3] Endocrine/Metabolic
Myalgia/Myopathy (<10%) Myalgia/Myopathy (<5%) Amenorrhea [2]
Gastrointestinal/Hepatic Appetite decreased (25%) [6]
Gastrointestinal/Hepatic Hyperglycemia [2]
Abdominal pain [2] Constipation [4]
Diarrhea [13] Hyponatremia (4%) [3]
Respiratory Hepatotoxicity [2] Hypophosphatemia [2]
Pneumonia [2] Nausea [11] Weight loss (45%) [15]
Endocrine/Metabolic Vomiting [7] Genitourinary
Hyponatremia [2] Endocrine/Metabolic Azotemia (2%)
SIADH [10] ALT increased [2] Other
Hematologic AST increased [2] Adverse effects [9]
Febrile neutropenia [5] SIADH [3] Death [3]
Hemolytic uremic syndrome [4] Hematologic
Hemotoxicity [2] Anemia [7]
Leukopenia [3]
Neutropenia [9]
Febrile neutropenia [5] VITAMIN A
Leukopenia [8]
Thrombocytopenia [9] Myelotoxicity [2] Trade name: Aquasol A (aaiPharma)
Ocular Neutropenia [26] Indications: Vitamin A deficiency
Ptosis [4] Thrombocytopenia [4] Class: Vitamin
Local Local Half-life: N/A
Injection-site irritation (<10%) Clinically important, potentially hazardous
Injection-site cellulitis (>10%)
Injection-site necrosis (<10%) interactions with: acitretin, alitretinoin,
Injection-site necrosis (>10%)
Injection-site phlebitis (12%) [2] bexarotene, cholestyramine, fish oil supplements,
Other isotretinoin, minocycline, orlistat, prednisone,
Adverse effects [7] Other tetracycline, warfarin
Death [6] Adverse effects [2] Pregnancy category: A (the pregnancy category
Infection [3] Death [2] will be X if used in doses above the RDA)
Infection [4]
Skin
VINORELBINE Dermatitis [7]
VISMODEGIB Pruritus [2]
Trade name: Navelbine (Kyowa) Xerosis (<10%)
Indications: Non-small cell lung cancer Trade name: Erivedge (Genentech)
Class: Antimitotic, Vinca alkaloid Indications: Basal cell carcinoma Hair
Half-life: 2844 hours Class: Hedgehog (Hh) signaling pathway inhibitor Alopecia [11]
Clinically important, potentially hazardous Half-life: 4–12 days Mucosal
interactions with: aldesleukin, itraconazole Clinically important, potentially hazardous Oral mucosal eruption [2]
VITAMIN E Over 100 updates per week on www.drugeruptiondata.com
Anaphylactoid reactions/Anaphylaxis (<2%)

VITAMIN E VORICONAZOLE Angioedema (<2%)
Cellulitis (<2%)
Synonym: alpha tocopherol Trade name: Vfend (Pfizer) Contact dermatitis (<2%)
Trade name: Aquasol E (aaiPharma) Indications: Invasive aspergillosis Cyanosis (<2%)
Indications: Vitamin E deficiency Class: Antibiotic, triazole, Antifungal, azole, Dermatitis (<2%)
Class: Vitamin CYP3A4 inhibitor Diaphoresis (<2%) [2]
Half-life: N/A Half-life: 624 hours (dose dependent) Ecchymoses (<2%)
Clinically important, potentially hazardous Clinically important, potentially hazardous Eczema (<2%)
interactions with: amprenavir, cholestyramine, interactions with: abiraterone, alfentanil, Edema (<2%)
orlistat, tipranavir, warfarin alfuzosin, almotriptan, alosetron, amphotericin B, Erythema [5]
Pregnancy category: A (the pregnancy category antineoplastics, apixaban, aprepitant, artemether/ Erythema multiforme (<2%)
will be C if used in doses above the RDA) lumefantrine, astemizole, atazanavir, atorvastatin, Exfoliative dermatitis (<2%)
barbiturates, benzodiazepines, boceprevir, Facial edema (<2%)
Skin bortezomib, bosentan, brigatinib, brinzolamide, Fixed eruption (<2%)
Dermatitis [13] buspirone, busulfan, cabazitaxel, cabozantinib, Furunculosis (<2%)
Erythema multiforme [3] calcifediol, calcium channel blockers, Graft-versus-host reaction (<2%)
Sclerosing lipogranuloma [2] carbamazepine, carvedilol, chloramphenicol, Granulomas (<2%)
chloroquine, ciclesonide, cilostazol, cinacalcet, Herpes simplex (<2%)
Genitourinary ciprofloxacin, cisapride, clopidogrel, cobicistat/
Prostate cancer (increased risk) [4] Lentigo [2]
elvitegravir/emtricitabine/tenofovir alafenamide, Lupus erythematosus (<2%) [5]
cobicistat/elvitegravir/emtricitabine/tenofovir Lymphadenopathy (<2%)
disoproxil, colchicine, conivaptan, copanlisib, Malignancies [2]
VORAPAXAR coumarins, crizotinib, cyclosporine, CYP2C19 Melanoma (<2%)
inhibitors and inducers, CYP2C9 inhibitors and Melanosis (<2%)
Trade name: Zontivity (Merck) substrates, CYP3A4 substrates, darunavir, Peripheral edema (<2%)
Indications: Reduction of thrombotic diazepam, diclofenac, didanosine, dienogest, Petechiae (<2%)
cardiovascular events in patients with a history of docetaxel, dofetilide, dronedarone, dutasteride, Photosensitivity (8%) [18]
myocardial infarction or with peripheral arterial efavirenz, eletriptan, eplerenone, ergot alkaloids, Phototoxicity [13]
disease ergotamine, erlotinib, esomeprazole, estrogens, Pigmentation (<2%)
Class: Protease-activated receptor-1 (PAR-1) eszopiclone, etravirine, everolimus, fentanyl, Pruritus (8%)
antagonist fesoterodine, food, gadobutrol, gefitinib, Psoriasis (<2%)
Half-life: 3–4 days grapefruit juice, guanfacine, halofantrine, HMG- Purpura (<2%)
Clinically important, potentially hazardous CoA reductase inhibitors, ibrutinib, ibuprofen, Rash (5%) [7]
interactions with: boceprevir, carbamazepine, imatinib, irinotecan, ixabepilone, lapatinib, Squamous cell carcinoma (<2%) [8]
clarithromycin, conivaptan, indinavir, itraconazole, lomitapide, lopinavir, losartan, macrolide Stevens-Johnson syndrome (<2%) [4]
ketoconazole, nefazodone, nelfinavir, phenytoin, antibiotics, maraviroc, meloxicam, methadone, Toxic epidermal necrolysis (<2%) [4]
posaconazole, rifampin, ritonavir, saquinavir, St methylergonovine, methylprednisolone, Urticaria (<2%)
John’s wort, strong CYP3A inhibitors or inducers, methysergide, midazolam, midostaurin, Xerosis (<2%) [2]
telaprevir, telithromycin mifepristone, mometasone, neratinib, nilotinib,
Pregnancy category: B nisoldipine, olaparib, ombitasvir/paritaprevir/ Hair
Important contra-indications noted in the ritonavir, omeprazole, oxycodone, palbociclib, Alopecia (<2%) [4]
prescribing guidelines for: nursing mothers; pantoprazole, paricalcitol, pazopanib, PEG- Nails
pediatric patients interferon, phenobarbital, phenytoin, Nail changes [3]
Note: Contra-indicated in patients with a history phosphodiesterase 5 inhibitors, pimecrolimus, Mucosal
of stroke, transient ischemic attack, or intracranial pimozide, ponatinib, prasugrel, progestins, Cheilitis (<2%) [4]
hemorrhage, or with active pathological bleeding. progestogens, protease inhibitors, proton pump Gingival bleeding (<2%)
Warning: BLEEDING RISK inhibitors, QT prolonging agents, quetiapine, Gingival hyperplasia/hypertrophy (<2%)
quinidine, quinine, ramelteon, ranolazine, Gingivitis (<2%)
Skin reboxetine, regorafenib, repaglinide, ribociclib, Glossitis (<2%)
Exanthems (2%) rifabutin, rifampin, rifapentine, rilpivirine, Rectal hemorrhage (<2%)
Rash (2%) ritonavir, rivaroxaban, romidepsin, ruxolitinib, Stomatitis (<2%)
salmeterol, saquinavir, saxagliptin, silodosin, Tongue edema (<2%)
Cardiovascular simeprevir, simvastatin, sirolimus, solifenacin,
Cardiotoxicity [2] Xerostomia (<2%)
sonidegib, sorafenib, St John’s wort, sucralfate,
Central Nervous System sulfonylureas, sunitinib, tacrolimus, tadalafil, Cardiovascular
Depression (2%) tamsulosin, telaprevir, temsirolimus, Arrhythmias (<2%)
Intracranial hemorrhage [5] tetrabenazine, thioridazine, ticagrelor, Atrial fibrillation (<2%)
tolterodine, tolvaptan, vemurafenib, venetoclax, Atrioventricular block (<2%)
Hematologic Bradycardia (<2%)
venlafaxine, vitamin K antagonists, ziprasidone,
Anemia (5%) Bundle branch block (<2%)
zolpidem
Bleeding (25%) [10] Cardiac arrest (<2%)
Ocular Important contra-indications noted in the Cardiomyopathy (<2%)
Diplopia (<2%) prescribing guidelines for: nursing mothers; Chest pain (<2%)
Retinopathy (<2%) pediatric patients Congestive heart failure (<2%)
Note: Safety and effectiveness in pediatric Extrasystoles (<2%)
Other
patients <12 years of age have not been Hypertension (<2%)
Adverse effects [3]
established. Hypotension (<2%)
Myocardial infarction (<2%)
Palpitation (<2%)
Skin Phlebitis (<2%)
Actinic keratoses [2]
Litt’s Drug Eruption & Reaction Manual VORICONAZOLE
Postural hypotension (<2%) Cholelithiasis (gallstones) (<2%) Oliguria (<2%)

QT prolongation (<2%) [11] Constipation (<2%) Urinary incontinence (<2%)
Supraventricular tachycardia (<2%) Diarrhea (<2%) [2] Urinary retention (<2%)
Tachycardia (2%) [2] Duodentitis (<2%) Urinary tract infection (<2%)
Thrombophlebitis (<2%) Dyspepsia (<2%) Uterine bleeding (<2%)
Torsades de pointes [7] Dysphagia (<2%) Vaginal bleeding (<2%)
Vasodilation (<2%) Esophagitis (<2%) Renal
Ventricular arrhythmia (<2%) Flatulence (<2%) Nephrotoxicity (<2%) [3]
Ventricular fibrillation (<2%) Gastroenteritis (<2%) Renal tubular necrosis (<2%)
Ventricular tachycardia (<2%) Gastrointestinal bleeding (<2%)
Gastrointestinal perforation (<2%) Hematologic
Central Nervous System Agranulocytosis (<2%)
Abnormal dreams (<2%) Gastrointestinal ulceration (<2%)
Hematemesis (<2%) Anemia (<2%)
Ageusia (taste loss) (<2%) Bone marrow suppression (<2%)
Agitation (<2%) Hepatic failure (<2%)
Hepatotoxicity [18] Eosinophilia (<2%)
Akathisia (<2%) Hemolytic anemia (<2%)
Amnesia (<2%) Nausea (5%) [3]
Pancreatitis (<2%) Leukopenia (<2%)
Anorexia (<2%) Pancytopenia (<2%)
Anxiety (<2%) Peritonitis (<2%)
Pseudomembranous colitis (<2%) Prothrombin time increased (<2%)
Cerebral edema (<2%) Sepsis (<2%)
Cerebral hemorrhage (<2%) Vomiting (4%) [2]
Thrombocytopenia (<2%)
Cerebral ischemia (<2%) Respiratory
Cerebrovascular accident (<2%) Cough (<2%) Otic
Chills (4%) Dysphonia (<2%) Ear pain (<2%)
Coma (<2%) Dyspnea (<2%) Hearing loss (<2%)
Confusion (<2%) [2] Flu-like syndrome (<2%) Hypoacusis (<2%)
Delirium (<2%) [2] Hemoptysis (<2%) Tinnitus (<2%)
Dementia (<2%) Hypoxia (<2%) Ocular
Depersonalization (<2%) Pharyngitis (<2%) Abnormal vision (19%)
Depression (<2%) Pleural effusion (<2%) Accommodation disorder (<2%)
Dysgeusia (taste perversion) (<2%) Pneumonia (<2%) Blepharitis (<2%)
Encephalitis (<2%) Pneumonitis [2] Conjunctivitis (<2%)
Encephalopathy (<2%) [3] Pulmonary embolism (<2%) Corneal opacity (<2%)
Euphoria (<2%) Respiratory distress (<2%) Diplopia (<2%)
Extrapyramidal symptoms (<2%) Rhinitis (<2%) Hallucinations, visual [4]
Fever (6%) Sinusitis (<2%) Keratitis (<2%)
Guillain–Barré syndrome (<2%) Upper respiratory tract infection (<2%) Keratoconjunctivitis (<2%)
Hallucinations (2%) [8] Endocrine/Metabolic Mydriasis (<2%)
Headache (3%) [3] ALP increased (4%) Night blindness (<2%)
Hypoesthesia (<2%) ALT increased [2] Nystagmus (<2%)
Insomnia (<2%) AST increased [2] Ocular adverse effects [2]
Intracranial pressure increased (<2%) Creatine phosphokinase increased (<2%) Ocular hemorrhage (<2%)
Neurotoxicity [6] Diabetes insipidus (<2%) Ocular pain (<2%)
Paresthesias (<2%) GGT increased (<2%) Oculogyric crisis (<2%)
Peripheral neuropathy [4] Hypercalcemia (<2%) Optic atrophy (<2%)
Psychosis (<2%) [2] Hypercholesterolemia (<2%) Optic neuritis (<2%)
Seizures (<2%) Hyperglycemia (<2%) Papilledema (<2%)
Somnolence (drowsiness) (<2%) Hyperkalemia (<2%) Photophobia (2%)
Status epilepticus (<2%) Hypermagnesemia (<2%) Retinitis (<2%)
Suicidal ideation (<2%) Hypernatremia (<2%) Scleritis (<2%)
Syncope (<2%) Hyperthyroidism (<2%) Uveitis (<2%)
Tremor (<2%) Hyperuricemia (<2%) Visual disturbances (19%) [14]
Vertigo (dizziness) (<2%) Hypervolemia (<2%) Xerophthalmia (<2%)
Neuromuscular/Skeletal Hypocalcemia (<2%) Local
Arthralgia (<2%) [2] Hypoglycemia (<2%) Injection-site infection (<2%)
Asthenia (fatigue) (<2%) [2] Hypokalemia (2%) [3] Injection-site inflammation (<2%)
Ataxia (<2%) Hypomagnesemia (<2%) Injection-site pain (<2%)
Back pain (<2%) Hyponatremia (<2%) Other
Bone or joint pain (<2%) Hypophosphatemia (<2%) Adverse effects (20%) [11]
Hypertonia (<2%) Hypothyroidism (<2%) Infection (<2%)
Leg cramps (<2%) Libido decreased (<2%) Multiorgan failure (<2%)
Myalgia/Myopathy (<2%) Pseudoporphyria [6] Periodontal infection (<2%)
Osteomalacia (<2%) Genitourinary
Osteoporosis (<2%) Anuria (<2%)
Periostitis deformans [22] Cystitis (<2%)
Skeletal fluorosis [2] Dysmenorrhea (<2%)
Gastrointestinal/Hepatic Dysuria (<2%)
Abdominal pain (<2%) Epididymitis (<2%)
Ascites (<2%) Glycosuria (<2%)
Black stools (<2%) Hematuria (<2%)
Cholecystitis (<2%) Impotence (<2%)
VORINOSTAT See all our books at www.crcpress.com
Gastrointestinal/Hepatic Pregnancy category: C

VORINOSTAT Abdominal pain [2] Important contra-indications noted in the
Constipation [2] prescribing guidelines for: nursing mothers;
Trade name: Zolinza (Merck) Diarrhea [7] pediatric patients
Indications: Cutaneous T-cell lymphoma Nausea [10] Warning: SUICIDAL THOUGHTS AND
Class: Antineoplastic, Histone deacetylase Vomiting [4] BEHAVIORS
(HDAC) inhibitor
Half-life: ~2 hours Respiratory
Clinically important, potentially hazardous Cough (11%) Skin
interactions with: alfuzosin, artemether/ Upper respiratory tract infection (10%) Hyperhidrosis [6]
lumefantrine, chloroquine, ciprofloxacin, Endocrine/Metabolic Pruritus (<3%)
coumarins, dronedarone, gadobutrol, nilotinib, Creatine phosphokinase increased [2] Mucosal
pimozide, QT prolonging agents, quinine, Dehydration [2] Xerostomia (6–8%) [16]
tetrabenazine, thioridazine, valproic acid, vitamin Hyperglycemia [3] Central Nervous System
K antagonists, ziprasidone Weight loss [4] Abnormal dreams (<3%) [2]
Pregnancy category: D Renal Agitation [2]
Important contra-indications noted in the Renal failure [2] Anxiety [2]
prescribing guidelines for: nursing mothers; Headache [24]
pediatric patients Hematologic
Anemia (14%) [7] Insomnia [6]
Febrile neutropenia [2] Somnolence (drowsiness) [3]
Skin Hemotoxicity [2] Vertigo (dizziness) (6–9%) [15]
Exanthems [2] Leukopenia [2] Neuromuscular/Skeletal
Peripheral edema (13%) Lymphopenia [5] Asthenia (fatigue) [7]
Pruritus (12%) Neutropenia [9] Gastrointestinal/Hepatic
Hair Thrombocytopenia [15] Constipation (3–6%) [11]
Alopecia (19%) [2] Other Diarrhea (7–10%) [13]
Mucosal Adverse effects [2] Flatulence (<3%)
Mucositis [2] Nausea (21–32%) [32]
Xerostomia (16%) Vomiting (3–6%) [15]
Cardiovascular VORTIOXETINE Respiratory
QT prolongation [3] Nasopharyngitis [5]
Central Nervous System Trade name: Trintellix (formerly Brintellix) Upper respiratory tract infection [2]
Anorexia [5] (Takeda) Endocrine/Metabolic
Chills (16%) Indications: Major depressive disorder Weight gain [2]
Dysgeusia (taste perversion) (28%) Class: Antidepressant, Serotonin receptor
agonist, Serotonin receptor antagonist, Serotonin Genitourinary
Fever (10%) Sexual dysfunction (<5%) [10]
Headache (12%) reuptake inhibitor
Vertigo (dizziness) (15%) Half-life: ~66 hours Other
Clinically important, potentially hazardous Adverse effects [2]
Neuromuscular/Skeletal interactions with: bupropion, carbamazepine,
Asthenia (fatigue) (52%) [11] fluoxetine, MAO inhibitors, paroxetine
hydrochloride, phenytoin, quinidine, rifampin
Litt’s Drug Eruption & Reaction Manual XYLOMETAZOLINE
herb, poplar, quassia, red clover, rue, turmeric

WARFARIN and willow bark. XIPAMIDE
Warning: BLEEDING RISK
Trade name: Coumadin (Bristol-Myers Squibb) See: www.drugeruptiondata.com/drug/id/1354
Indications: Thromboembolic disease,
pulmonary embolism Skin
Class: Anticoagulant, Coumarin
Half-life: 1.52.5 days (highly variable) Calcification [3] XYLOMETAZOLINE
Clinically important, potentially hazardous Dermatitis [2]
Ecchymoses [2] Trade name: Otrivine (Novartis)
interactions with: acemetacin, amiodarone, Indications: Nasal congestion, perennial and
amobarbital, amprenavir, antithyroid agents, Exanthems [7]
Gangrene [6] allergic rhinitis, sinusitis
aprepitant, aprobarbital, aspirin, atazanavir, Class: Alpha adrenoceptor agonist
atorvastatin, azathioprine, azithromycin, Hematoma [2]
Hypersensitivity [3] Half-life: N/A
barbiturates, beclomethasone, betamethasone, Clinically important, potentially hazardous
bezafibrate, bismuth, bivalirudin, boceprevir, Necrosis (>10%) [117]
Pruritus [2] interactions with: none known
bosentan, butabarbital, capecitabine, cefixime, Pregnancy category: C
celecoxib, ceritinib, chondroitin, cimetidine, Purplish erythema (feet and toes) [8]
Purpura [3] Important contra-indications noted in the
ciprofloxacin, clarithromycin, clofibrate, prescribing guidelines for: nursing mothers
clopidogrel, clorazepate, co-trimoxazole, Rash [2]
cobicistat/elvitegravir/emtricitabine/tenofovir Urticaria [3]
alafenamide, cobicistat/elvitegravir/emtricitabine/ Vasculitis [7] Mucosal
tenofovir disoproxil, colesevelam, cyclosporine, Hair Epistaxis (nosebleed) [2]
danazol, daptomycin, darunavir, delavirdine, Alopecia (>10%) [6] Mucosal bleeding [2]
desvenlafaxine, dexamethasone, dexibuprofen, Central Nervous System
dexlansoprazole, diclofenac, dicloxacillin, Headache [2]
dirithromycin, disulfiram, dronedarone, Intracranial hemorrhage [2]
duloxetine, econazole, efavirenz, enzalutamide, Vertigo (dizziness) [2]
ergotamine, erlotinib, erythromycin,
eslicarbazepine, etoricoxib, exenatide, Neuromuscular/Skeletal
fenofibrate, fluconazole, flunisolide, Rhabdomyolysis [2]
fluoxymesterone, fosamprenavir, gefitinib, Gastrointestinal/Hepatic
gemfibrozil, glucagon, grapefruit juice, heparin, Black stools [2]
imatinib, influenza vaccine, itraconazole, Gastrointestinal bleeding [5]
ketoconazole, leflunomide, lepirudin, Hematemesis [2]
levofloxacin, levothyroxine, liothyronine, Genitourinary
liraglutide, lomitapide, lopinavir, menadione, Priapism [4]
mephobarbital, methimazole, methyl salicylate,
methylprednisolone, methyltestosterone, Renal
metronidazole, miconazole, mifepristone, Nephrotoxicity [3]
moricizine, moxifloxacin, nafcillin, nalidixic acid, Hematologic
nandrolone, nilutamide, norfloxacin, obeticholic Anticoagulation [3]
acid, ofloxacin, omeprazole, oritavancin, orlistat, Bleeding [17]
pantoprazole, PEG-interferon, penicillin G, Hemorrhage [8]
penicillin V, penicillins, pentobarbital, Prothrombin time increased [5]
phenobarbital, phenylbutazones, phytonadione,
Other
piperacillin, piroxicam, prasugrel, primidone,
Adverse effects [8]
propoxyphene, propranolol, propylthiouracil,
Death [2]
quinidine, quinine, rabeprazole, resveratrol,
rifampin, rifapentine, rofecoxib, romidepsin,
ropinirole, rosuvastatin, roxithromycin,
salicylates, secobarbital, simvastatin, sitaxentan,
sorafenib, St John’s wort, stanozolol,
sulfamethoxazole, sulfinpyrazone, sulfisoxazole,
sulfonamides, sulindac, tamsulosin, tegafur/
gimeracil/oteracil, telaprevir, telithromycin,
teriflunomide, testosterone, tibolone, tigecycline,
tinidazole, tolmetin, tolterodine, triamcinolone,
troleandomycin, uracil/tegafur, valdecoxib,
vemurafenib, venlafaxine, vilazodone, vitamin A,
vitamin E, zafirlukast, zileuton
Pregnancy category: X (category D for women
with mechanical heart valves)
Note: Alternative remedies, including herbals,
may potentially increase the risk of bleeding or
potentiate the effects of warfarin therapy. Some
of these include the following: angelica root,
arnica flower, anise, asafetida, bogbean, borage
seed oil, bromelain, dan-shen, devil’s claw,
fenugreek, feverfew, garlic, ginger, ginkgo biloba,
ginseng, horse chestnut, lovage root,
meadowsweet, onion, parsley, passionflower
YELLOW FEVER VACCINE Over 100 updates per week on www.drugeruptiondata.com

YELLOW FEVER ZAFIRLUKAST Neurotoxicity [2]
VACCINE Trade name: Accolate (AstraZeneca) Neuromuscular/Skeletal
Indications: Asthma Myalgia/Myopathy (<6%)
Trade names: Stamaril (Sanofi Pasteur), YF-VAX Class: Leukotriene receptor antagonist Other
(Sanofi Pasteur) Half-life: 10 hours Side effects [2]
Indications: Immunization against yellow fever Clinically important, potentially hazardous
Class: Vaccine interactions with: aminophylline, aspirin,
Half-life: N/A
carvedilol, CYP2C9 substrates, CYP3A4
substrates, erythromycin, high protein foods,
ZALEPLON
interactions with: azathioprine, belimumab, interferon alfa, primidone, vitamin K antagonists,
corticosteroids, fingolimod, hydroxychloroquine, Trade name: Sonata (Wyeth)
warfarin Indications: Insomnia
immunosuppressants, interferon-gamma, Pregnancy category: B
leflunomide, mercaptopurine, prednisone, Class: Hypnotic, non-benzodiazepine
Important contra-indications noted in the Half-life: 1 hour
tocilizumab, ustekinumab prescribing guidelines for: nursing mothers;
Pregnancy category: C Clinically important, potentially hazardous
pediatric patients interactions with: alcohol, cimetidine,
Important contra-indications noted in the Note: Contra-indicated in patients with hepatic
prescribing guidelines for: the elderly; nursing erythromycin, imipramine, ketoconazole,
impairment including hepatic cirrhosis. promethazine, rifampin, rifapentine, thioridazine
Note: Contra-indicated in patients with
hypersensitivity to egg or chick embryo protein.
Churg-Strauss syndrome [6] prescribing guidelines for: nursing mothers;
Central Nervous System pediatric patients
Skin
Anaphylactoid reactions/Anaphylaxis [8] Fever (2%)
Hypersensitivity [2] Headache (13%) Cardiovascular
Rash (3%) Pain (generalized) (2%) Tachycardia [2]
Urticaria [2] Vertigo (dizziness) (2%) Central Nervous System
Central Nervous System Neuromuscular/Skeletal Amnesia (2–4%)
Encephalopathy [4] Asthenia (fatigue) (2%) Anorexia (<2%)
Fever (low-grade) (<5%) [3] Back pain (2%) Confusion [2]
Headache (<30%) [2] Myalgia/Myopathy (2%) Depersonalization (<2%)
Myelitis [2] Gastrointestinal/Hepatic Hallucinations [3]
Neurotoxicity [11] Abdominal pain (2%) Headache (30–42%) [3]
Diarrhea (3%) Hypoesthesia (<2%)
Neuromuscular/Skeletal Paresthesias (3%)
Asthenia (fatigue) (10–30%) [2] Nausea (3%)
Vomiting (2%) Parosmia (<2%)
Myalgia/Myopathy (10–30%) [2] Slurred speech [2]
Gastrointestinal/Hepatic Respiratory Somnambulism [2]
Diarrhea (<10%) [2] Cough [2] Somnolence (drowsiness) (5–6%) [4]
Hepatitis [2] Other Tremor (2%)
Nausea (<10%) Infection (4%) Vertigo (dizziness) (7–9%) [4]
Vomiting (<10%) [2] Neuromuscular/Skeletal
Respiratory Asthenia (fatigue) (5–7%)
Influenza [2] ZALCITABINE Ataxia [2]
Local Gastrointestinal/Hepatic
Synonyms: dideoxycytidine; ddC Abdominal pain (6%)
Infusion-site erythema (<5%)
Trade name: Hivid (Roche) Nausea (6–8%)
Indications: Advanced HIV infection Vomiting [2]
Other Class: Antiretroviral, Nucleoside analog reverse
Adverse effects [14] transcriptase inhibitor Genitourinary
Death [13] Half-life: 2.9 hours Dysmenorrhea (3–4%)
Multiorgan failure [3] Clinically important, potentially hazardous Otic
Viscerotropic disease [20] interactions with: none known Hyperacusis (<2%)
Pregnancy category: C Ocular
Important contra-indications noted in the Ocular pain (3–4%)
mothers; pediatric patients Other
Adverse effects [2]
Viscerotropic disease [2]
Skin
Edema [3]
Exanthems [9]
Pruritus (35%) ZANAMIVIR
Rash (211%) [2]
Urticaria (3%) Trade name: Relenza (GSK)
Indications: Influenza A and B
Mucosal Class: Antiviral, Neuraminidase inhibitor
Aphthous stomatitis [6] Half-life: 2.55.1 hours
Oral lesions (4073%) [3] Clinically important, potentially hazardous
Oral ulceration (364%) [4] interactions with: live attenuated influenza
Stomatitis (3%) vaccine
Litt’s Drug Eruption & Reaction Manual ZIDOVUDINE
Pregnancy category: C Mucosal

Important contra-indications noted in the Xerostomia (~2%) ZIDOVUDINE
prescribing guidelines for: nursing mothers Cardiovascular Synonyms: azidothymidine; AZT
Atrial fibrillation (~2%) Trade names: Combivir (ViiV), Retrovir (ViiV),
Skin Chest pain (~2%) Trizivir (ViiV)
Urticaria (<2%) Hypertension (~2%) Indications: HIV infection
Mucosal Hypotension (~2%) Class: Antiretroviral, Nucleoside analog reverse
Nasal discomfort (12%) Tachycardia (~2%) transcriptase inhibitor
Central Nervous System Central Nervous System Half-life: 0.5–3 hours
Anorexia (4%) Amnesia (8%) Clinically important, potentially hazardous
Chills (5–9%) Anorexia (6%) interactions with: atovaquone, bone marrow
Fever (5–9%) Anxiety (8%) suppressives, clarithromycin, darunavir,
Headache (13–24%) [2] Chills (~2%) diclofenac, doxorubicin, fluconazole, ganciclovir,
Vertigo (dizziness) (<2%) Confusion (15%) [5] indinavir, interferon alfa, interferon beta, lopinavir,
Depression (~2%) meloxicam, methadone, NSAIDs, PEG-
Neuromuscular/Skeletal Dysarthria (7%) interferon, phenytoin, probenecid,
Arthralgia (<2%) Dysesthesia (7%) pyrimethamine, ribavirin, rifampin, rifapentine,
Asthenia (fatigue) (5–8%) Dysgeusia (taste perversion) (5%) stavudine, tipranavir, valproic acid
Bone or joint pain (6%) Fever (5%) Pregnancy category: C
Myalgia/Myopathy (<8%) Hallucinations [3] Important contra-indications noted in the
Gastrointestinal/Hepatic Headache (13%) prescribing guidelines for: the elderly; nursing
Abdominal pain (<2%) Hyperesthesia (~2%) mothers
Diarrhea (3%) [2] Insomnia (6%) Note: Combivir is zidovudine and lamivudine;
Nausea (3%) [2] Pain (11%) Trizivir is zidovudine, abacavir and lamivudine.
Respiratory Paresthesias (7%) Warning: HEMATOLOGICAL TOXICITY,
Bronchitis (2%) Rigors (7%) MYOPATHY, LACTIC ACIDOSIS AND SEVERE
Bronchospasm [3] Seizures (<2%) HEPATOMEGALY, and EXACERBATIONS OF
Cough (7–17%) Somnolence (drowsiness) (17%) [3] HEPATITIS B
Respiratory failure [2] Suicidal ideation (<2%)
Sinusitis (2%) Tremor (7%) Skin
Upper respiratory tract infection (3–13%) Twitching (~2%) Acneform eruption (<5%)
[2] Vertigo (dizziness) (47%) [8] Bromhidrosis (<5%)
Endocrine/Metabolic Neuromuscular/Skeletal Diaphoresis (519%)
Appetite decreased (4%) Arthralgia (~2%) Edema of lip (<5%)
Appetite increased (4%) Asthenia (fatigue) (18%) Erythema multiforme [2]
Ataxia (14%) Exanthems (<5%) [6]
Other Back pain (~2%) Lipoatrophy [2]
Infection (2%) Muscle spasm (6%) Lipodystrophy [2]
Myalgia/Myopathy (~2%) Pigmentation [10]
Rhabdomyolysis (<2%) Pruritus [4]
ZICONOTIDE Gastrointestinal/Hepatic Rash (17%) [8]
Abdominal pain (~2%) Stevens-Johnson syndrome [4]
Trade name: Prialt (Jazz) Diarrhea (18%) Toxic epidermal necrolysis [3]
Indications: Analgesic, severe chronic pain Nausea (40%) [3] Urticaria (<5%) [2]
Class: Neuronal calcium channel blocker Vomiting (16%) [2] Vasculitis [2]
Half-life: 4.6 hours Hair
Flu-like syndrome (~2%) Alopecia [2]
interactions with: CNS depressants Hypertrichosis (eyelashes) [2]
Pregnancy category: C Sinusitis (5%)
Important contra-indications noted in the Genitourinary Nails
prescribing guidelines for: the elderly; nursing Urinary retention (9%) [3] Nail pigmentation [27]
mothers; pediatric patients Otic Mucosal
Note: Ziconotide is a synthetic analog of a Tinnitus (~2%) Oral lichenoid eruption [2]
substance isolated from the venom of carnivorous Oral pigmentation [7]
oceanic snails that sting their prey with a cocktail Ocular Oral ulceration (<5%)
of neurotoxins injected through a harpoon-like Diplopia (~2%) Tongue edema (<5%)
tube. Ziconotide is 100 to 1,000 times more Nystagmus (8%) [2] Tongue pigmentation [4]
powerful than morphine. Periorbital edema (~2%)
Photophobia (~2%) Central Nervous System
Warning: NEUROPSYCHIATRIC ADVERSE Dysgeusia (taste perversion) (519%) [2]
REACTIONS Vision blurred (12%) [2]
Visual disturbances (10%) Headache [3]
Paresthesias (<8%)
Skin Other
Adverse effects [3] Neuromuscular/Skeletal
Cellulitis (~2%) Asthenia (fatigue) [3]
Diaphoresis (5%) Infection (~2%)
Ecchymoses (~2%)
Edema (~2%) Gastrointestinal/Hepatic
Pruritus (7%) Abdominal pain [3]
Xerosis (~2%) Diarrhea [2]
Hepatotoxicity [2]
Nausea [3]
ZIDOVUDINE See all our books at www.crcpress.com
Pancreatitis [3] Neuroleptic malignant syndrome [6]

Vomiting [2] ZIPRASIDONE Paralysis (<10%)
Endocrine/Metabolic Paresthesias (<2%)
Trade name: Geodon (Pfizer) Sedation [4]
Acidosis [6] Indications: Schizophrenia, bipolar I disorder Somnolence (drowsiness) (8–31%) [10]
Hematologic Class: Antipsychotic Speech disorder (2%)
Anemia [13] Half-life: 7 hours Tardive dyskinesia [5]
Neutropenia [3] Clinically important, potentially hazardous Tremor (<10%) [2]
Other interactions with: acetylcholinesterase Twitching (<10%)
Adverse effects [9] inhibitors, alcohol, alfuzosin, amitriptyline, Vertigo (dizziness) (3–16%) [2]
Teratogenicity [2] amoxapine, amphetamines, antifungals, arsenic,
artemether/lumefantrine, asenapine, astemizole, Neuromuscular/Skeletal
carbamazepine, chloroquine, ciprofloxacin, Asthenia (fatigue) (2–6%) [2]
citalopram, CNS depressants, conivaptan, Dystonia (<10%) [6]
ZILEUTON dasatinib, degarelix, dolasetron, dopamine Hypertonia (<10%)
agonists, dopamine agonists, dronedarone, food, Myalgia/Myopathy (2%)
Trade name: Zyflo (AbbVie) gadobutrol, ketoconazole, lapatinib, levodopa, Rhabdomyolysis [2]
Indications: Asthma levofloxacin, lithium, methylphenidate, Gastrointestinal/Hepatic
Class: Leukotriene receptor antagonist metoclopramide, moxifloxacin, nilotinib, Abdominal pain (<2%)
Half-life: 2.5 hours pazopanib, pimavanserin, pimozide, QT Constipation (2–9%)
Clinically important, potentially hazardous prolonging agents, quinagolide, quinine, Diarrhea (3–5%)
interactions with: anisindione, anticoagulants, ranolazine, St John’s wort, telavancin, Dyspepsia (<8%)
astemizole, dicumarol, methylergonovine, telithromycin, tetrabenazine, thioridazine, Dysphagia (2%)
pimozide, propranolol, warfarin voriconazole, vorinostat Nausea (4–12%) [2]
Pregnancy category: C Pregnancy category: C Vomiting (3–5%)
prescribing guidelines for: the elderly; nursing Cough (increased) (3%)
pediatric patients mothers; pediatric patients Dyspnea (2%)
Note: Ziprasidone should be avoided in patients Pharyngitis (3%)
Neuromuscular/Skeletal with congenital long QT syndrome or a history of Respiratory tract infection (8%)
Myalgia/Myopathy (3%) cardiac arrhythmias. Rhinitis (<4%)
Warning: INCREASED MORTALITY IN Upper respiratory tract infection (8%)
ELDERLY PATIENTS WITH DEMENTIA-
Endocrine/Metabolic
ZINC RELATED PSYCHOSIS
Galactorrhea [3]
Trade name: Cold-Eeze (The Quigley Corp) Skin Weight gain [7]
Indications: Supplement to intravenous solutions Angioedema [2]
given for total parenteral nutrition (TPN) Diaphoresis (2%) Genitourinary
Class: Food supplement, Trace element DRESS syndrome [2] Dysmenorrhea (2%)
Half-life: N/A Fungal dermatitis (2%) Priapism [4]
Clinically important, potentially hazardous Furunculosis (2%) Ocular
interactions with: chlorothiazide, Lupus erythematosus [2] Abnormal vision (3–6%)
chlortetracycline, chlorthalidone, ciprofloxacin, Rash (4%) Local
cisplatin, deferoxamine, demeclocycline, Urticaria (5%) Infusion-site pain (7–9%)
doxycycline, eltrombopag, ethambutol, ferrous Mucosal
sulfate, gatifloxacin, gemifloxacin, Other
Rectal hemorrhage (2%) Adverse effects [8]
hydrochlorothiazide, indapamide, levofloxacin, Sialorrhea (4%)
lymecycline, metolozone, minocycline, Death [2]
Tongue edema (3%)
moxifloxacin, norfloxacin, ofloxacin, Xerostomia (<5%)
oxytetracycline, propofol, tetracycline, valproic
acid Cardiovascular ZOFENOPRIL
Pregnancy category: C Bradycardia (2%)
Note: Zinc is found in meats, seafood, dairy Chest pain (3%) See: www.drugeruptiondata.com/drug/id/1312
products, legumes, nuts, whole grains. Zinc oxide Hypertension (2–3%)
and zinc sulfate are used to fortify wheat Postural hypotension (5%)
products. QT prolongation [22]
Tachycardia (2%) [2] ZOLEDRONATE
Skin Synonym: zoledronic acid
Churg-Strauss syndrome [2] Central Nervous System Trade names: Aclasta (Novartis), Reclast
Dermatitis [4] Agitation (2%) [3] (Novartis), Zometa (Novartis)
Akathisia (2–10%) [5] Indications: Hypercalcemia of malignancy,
Mucosal Anorexia (2%)
Oral mucosal irritation [2] Paget’s disease, osteoporosis
Anxiety (2–5%) [2] Class: Bisphosphonate
Central Nervous System Depression [2] Half-life: 7 days
Anosmia [2] Dyskinesia (<10%) [2] Clinically important, potentially hazardous
Dysgeusia (taste perversion) [5] Extrapyramidal symptoms (2–31%) [5] interactions with: aminoglycosides,
Headache (3–18%) [3] bisphosphonates, loop diuretics, nephrotoxics
Hyperesthesia (<2%)
Hypokinesia (<5%)
Insomnia (3%) [5]
Mania [2]
Litt’s Drug Eruption & Reaction Manual ZOLPIDEM
Pregnancy category: D Hypokalemia (12%) Myalgia/Myopathy (2%) [2]

Important contra-indications noted in the Hypomagnesemia (11%) Neck pain (4–10%)
prescribing guidelines for: the elderly; nursing Hypophosphatemia (13%) [3] Gastrointestinal/Hepatic
mothers; pediatric patients Weight loss (16%) Dyspepsia (<3%)
Genitourinary Dysphagia (<2%)
Skin Urinary tract infection (12–14%) Nausea (4–9%)
Candidiasis (12%) Renal Renal
Dermatitis (11%) Fanconi syndrome [2] Nephrotoxicity [2]
Dermatomyositis [3] Nephrotoxicity [14]
Edema [3] Other
Renal failure [4] Adverse effects [6]
Neoplasms (malignant / aggrevated) (20%) Renal function abnormal [2]
Peripheral edema (5–21%)
Rash [3] Hematologic
Hair
Anemia (22–33%) [8]
Granulocytopenia (5–10%)
ZOLPIDEM
Alopecia (12%) Neutropenia (12%) Trade name: Ambien (Sanofi-Aventis)
Mucosal Pancytopenia (5–10%) Indications: Insomnia
Mucositis (5–10%) Thrombocytopenia (5–10%) Class: Hypnotic, non-benzodiazepine
Stomatitis (8%) Ocular Half-life: 2.6 hours
Cardiovascular Ocular adverse effects [2] Clinically important, potentially hazardous
Atrial fibrillation [3] Ocular inflammation [3] interactions with: alcohol, antihistamines,
Chest pain (5–10%) Scleritis [2] azatadine, azelastine, brompheniramine,
Hypotension (11%) Uveitis [10] buclizine, chlorpheniramine, chlorpromazine,
Central Nervous System Other cimetidine, clemastine, cobicistat/elvitegravir/
Agitation (13%) Adverse effects [6] emtricitabine/tenofovir alafenamide, cobicistat/
Anorexia (9–22%) Infection (5–10%) elvitegravir/emtricitabine/tenofovir disoproxil,
Anxiety (11–14%) dexchlorpheniramine, erythromycin, imipramine,
Chills [2] ketoconazole, meclizine, pizotifen, ramelteon,
rifampin, rifapentine, ritonavir, telaprevir,
Confusion (7–13%)
Depression (14%)
ZOLMITRIPTAN voriconazole
Fever (32–44%) [20] Pregnancy category: C
Trade name: Zomig (AstraZeneca) Important contra-indications noted in the
Headache (5–19%) [4] Indications: Migraine attacks
Hypoesthesia (12%) prescribing guidelines for: nursing mothers;
Class: 5-HT1 agonist, Serotonin receptor agonist, pediatric patients
Insomnia (15–16%) Triptan
Paresthesias (15%) Half-life: 3 hours
Rigors (11%) Clinically important, potentially hazardous Skin
Seizures [2] interactions with: cimetidine, ciprofloxacin, Rash (2%)
Somnolence (drowsiness) (5–10%) dihydroergotamine, ergot-containing drugs, Mucosal
Vertigo (dizziness) (18%) fluoxetine, fluvoxamine, isocarboxazid, Xerostomia (3%) [3]
Neuromuscular/Skeletal levofloxacin, MAO inhibitors, methysergide, Cardiovascular
Arthralgia (5–10%) [9] moclobemide, moxifloxacin, naratriptan, Palpitation (2%)
Asthenia (fatigue) (5–39%) [11] norfloxacin, ofloxacin, oral contraceptives, Tachycardia [2]
Back pain (15%) phenelzine, propranolol, rizatriptan, sertraline, Torsades de pointes [2]
Bone or joint pain (12–55%) [15] sibutramine, SNRIs, SSRIs, St John’s wort,
Fractures [4] sumatriptan, tranylcypromine Central Nervous System
Myalgia/Myopathy (23%) [7] Pregnancy category: C Amnesia [16]
Osteonecrosis [52] Important contra-indications noted in the Anxiety [2]
Pain in extremities (14%) prescribing guidelines for: nursing mothers; Compulsions [2]
pediatric patients Confusion [3]
Gastrointestinal/Hepatic Delirium [5]
Abdominal pain (14–16%) Depression (2%)
Constipation (27–31%) [3] Skin Dysgeusia (taste perversion) [4]
Diarrhea (17–24%) [2] Diaphoresis (2–3%) Gait instability [3]
Dyspepsia (10%) Hot flashes (>10%) Hallucinations [13]
Dysphagia (5–10%) Mucosal Headache (7%) [11]
Hepatotoxicity [3] Xerostomia (3–5%) Nightmares [2]
Nausea (29–46%) [12] Seizures [7]
Vomiting (14–32%) [2] Cardiovascular
Chest pain (2–4%) Sleep related disorder [19]
Respiratory Myocardial infarction [4] Slurred speech [2]
Cough (12–22%) Somnambulism [16]
Dyspnea (22–27%) Central Nervous System Somnolence (drowsiness) (2–8%) [10]
Flu-like syndrome [8] Dysgeusia (taste perversion) [4] Vertigo (dizziness) (<5%) [12]
Pharyngolaryngeal pain (8%) Headache [2]
Neurotoxicity [2] Neuromuscular/Skeletal
Upper respiratory tract infection (10%) Asthenia (fatigue) (3%) [4]
Paresthesias (5–9%) [5]
Endocrine/Metabolic Somnolence (drowsiness) (5–8%) Ataxia [3]
Appetite decreased (13%) Vertigo (dizziness) (2–10%) [2] Back pain (3%)
Creatine phosphokinase increased [2] Warm feeling (5–7%) Fractures [2]
Dehydration (5–14%) Myalgia/Myopathy (7%)
Hyperparathyroidism [2] Neuromuscular/Skeletal
Hypocalcemia (5–10%) [25] Jaw pain (4–10%)
ZOLPIDEM Over 100 updates per week on www.drugeruptiondata.com
Gastrointestinal/Hepatic Schizophrenia (2%)

Abdominal pain (2%) Somnolence (drowsiness) (17%) [22] ZOTAROLIMUS
Constipation (2%) Speech disorder (2–5%)
Diarrhea (<3%) Suicidal ideation [2] Trade names: Endeavor (Medtronic), ZoMaxx
Hepatotoxicity [2] Vertigo (dizziness) (13%) [18] Drug-Eluting Coronary Stent (AbbVie)
Nausea [5] Indications: Ischemic heart disease, restenosis
Neuromuscular/Skeletal Class: Angiogenesis inhibitor, Macrolide
Vomiting [2] Asthenia (fatigue) (7–8%) [9] immunosuppressant (derivative of sirolimus),
Respiratory Ataxia (6%) [3] mTOR inhibitor
Flu-like syndrome (2%) Gastrointestinal/Hepatic Half-life: 33–36 hours
Pharyngitis (3%) Abdominal pain (6%) Clinically important, potentially hazardous
Sinusitis (4%) Constipation (2%) interactions with: ketoconazole, sirolimus
Ocular Diarrhea (5%) Pregnancy category: C
Hallucinations, visual [8] Dyspepsia (3%) Important contra-indications noted in the
Other Nausea (9%) [2] prescribing guidelines for: nursing mothers;
Adverse effects [8] Vomiting [2] pediatric patients
Allergic reactions (4%) Respiratory
Flu-like syndrome (4%) Skin
Pneumonitis [2] Rash (<6%)
Rhinitis (2%) Xerosis (<13%)
ZONISAMIDE
Trade name: Zonegran (Concordia) Appetite decreased [7] Cardiotoxicity [4]
Indications: Epilepsy Weight loss (3%) [20] Myocardial infarction [3]
Class: Anticonvulsant, Antiepileptic, sulfonamide Renal Subacute thrombosis [2]
Half-life: 63 hours Nephrolithiasis [4] Central Nervous System
Clinically important, potentially hazardous Nephrotoxicity [2] Headache (4–13%)
interactions with: caffeine, metformin Pain (13–63%)
Pregnancy category: C Ocular
Important contra-indications noted in the Diplopia (6%) [2] Gastrointestinal/Hepatic
prescribing guidelines for: nursing mothers; Nystagmus (4%) Abdominal pain (<6%)
pediatric patients Other Diarrhea (<6%)
Note: Zonisamide is a sulfonamide and can be Adverse effects [12] Genitourinary
absorbed systemically. Sulfonamides can produce Side effects [4] Hematuria (<13%)
severe, possibly fatal, reactions such as toxic Teratogenicity [2] Local
epidermal necrolysis and Stevens-Johnson Application-site reactions (13–63%)
syndrome. Injection-site reactions (13–38%)
ZOSTER VACCINE
Skin
DRESS syndrome [3] Trade name: Zostavax (Oka/Merck)
ZUCLOPENTHIXOL
Ecchymoses (2%) Indications: To reduce the risk of developing
Hypersensitivity [4] herpes zoster (in people over 60) See: www.drugeruptiondata.com/drug/id/1344
Oligohydrosis [8] Class: Vaccine
Purpura (2%) Half-life: N/A
Rash (3%) [6] Clinically important, potentially hazardous
Stevens-Johnson syndrome [3] interactions with: none known ZUCLOPENTHIXOL
Mucosal ACETATE
Xerostomia (2%)
Central Nervous System Skin See: www.drugeruptiondata.com/drug/id/1273
Agitation (9%) [4] Herpes zoster [7]
Anorexia (13%) [9] Rash [2]
Anxiety (3%) Central Nervous System ZUCLOPENTHIXOL
Cognitive impairment (6%) [4] Fever (<2%)
Confusion (6%) Headache [4] DECANOATE
Depression (6%) [4] Respiratory
Dysgeusia (taste perversion) (2%) See: www.drugeruptiondata.com/drug/id/1272
Flu-like syndrome (<2%)
Fever [2]
Headache (10%) [7] Local
Injection-site edema [2]
Insomnia (6%)
Irritability (9%) [4] Injection-site erythema [2] ZUCLOPENTHIXOL
Mania [2] Injection-site pain [2] DIHYDROCHLORIDE
Nervousness (2%) Injection-site reactions [8]
Neuroleptic malignant syndrome [2] Other See: www.drugeruptiondata.com/drug/id/1274
Paresthesias (4%) Adverse effects [2]
Psychosis [3] Death [2]
DESCRIPTIONS OF IMPORTANT REACTIONS
Acanthosis nigricans Ageusia

Acanthosis nigricans (AN) is a process characterized by a soft, velvety, Ageusia is the loss of taste functions of the tongue, essentially the inability to
brown or grayish-black thickening of the skin that is symmetrically detect sweet, sour, bitter, or salty substances, and umami (the taste of
distributed over the axillae, neck, inguinal areas and other body folds. monosodium glutamate).
While most cases of AN are seen in obese and prepubertal children, it can Atorvastatin, captopril, enalapril, indomethacin, and paroxetine are some
occur as a marker for various endocrinopathies as well as in female patients of the drugs that can occasion ageusia.
with elevated testosterone levels, irregular menses, and hirsutism.
It is frequently a concomitant of an underlying malignant condition, Alopecia
principally an adenocarcinoma of the intestinal tract. Many drugs have been reported to occasion hair loss. Commonly appearing
as a diffuse alopecia, it affects women more frequently than men and is
Acneform lesions limited in most instances to the scalp. Axillary and pubic hairs are rarely
Acneform eruptions are inflammatory follicular reactions that resemble acne affected except with anticoagulants.
vulgaris and that are manifested clinically as papules or pustules. They are The hair loss from cytostatic agents, which is dose-dependent and begins
monomorphic reactions, have a monomorphic appearance, and are found about 2 weeks after the onset of therapy, is a result of the interruption of the
primarily on the upper parts of the body. Unlike acne vulgaris, there are anagen (growing) cycle of hair. With other drugs the hair loss does not begin
rarely comedones present. Consider a drug-induced acneform eruption if: until 2–5 months after the medication has been begun. With cholesterol-
l The onset is sudden lowering drugs, diffuse alopecia is a result of interference with normal
l There is a worsening of existing acne lesions keratinization.
The scalp is normal and the drug-induced alopecia is almost always
l The extent is considerable from the outset
reversible within 1–3 months after the therapy has been discontinued. The
l The appearance is monomorphic regrown hair is frequently depigmented and occasionally more curly
l The localization is unusual for acne as, for example, when the distal The most frequent offenders are cytostatic agents and anticoagulants, but
extremities are involved hair loss can occur with a variety of common drugs, including hormones,
l The patient’s age is unusual for regular acne anticonvulsants, amantadine, amiodarone, captopril, cholesterol-lowering
l There is an exposure to a potentially responsible drug. drugs, cimetidine, colchicine, etretinate, isotretinoin, ketoconazole, heavy
metals, lithium, penicillamine, valproic acid, and propranolol.
The most common drugs responsible for acneform eruptions are: ACTH,
androgenic hormones, anticonvulsants (hydantoin derivatives, phenobarbital, Angioedema
trimethadione), corticosteroids, danazol, disulfiram, halogens (bromides,
Angioedema is a term applied to a variant of urticaria in which the
chlorides, iodides), lithium, oral contraceptives, tuberculostatics (ethiona-
subcutaneous tissues, rather than the dermis, are mainly involved.
mide, isoniazid, rifampin), vitamins B2, B6 and B12.
Also known as Quincke’s edema, giant urticaria, and angioneurotic edema,
this acute, evanescent, skin-colored, circumscribed edema usually affects the
Acute febrile neutrophilic dermatosis
most distensible tissues: the lips, eyelids, earlobes, and genitalia. It can also
Acute febrile neutrophilic dermatosis is a disorder that appears more affect the mucous membranes of the tongue, mouth, and larynx.
frequently in females and has several characteristic features. Symptoms of angioedema, frequently unilateral, asymmetrical and non-
The lesions - tender, erythematous or purple, annular plaques or nodules - pruritic, last for an hour or two but can persist for 2–5 days.
appear suddenly and are most prominent on the face, neck and upper The etiological factors associated with angioedema are as varied as that of
extremities. Pain and fever often accompany the eruption. urticaria (see separate entry).
While the cause is unknown, about 15% of the patients have some type of
myeloproliferative disorder, primarily leukemias. Anosmia
Drugs commonly reported to cause Sweet’s syndrome are clofazimine,
Anosmia, or odor blindness, is the total absence of the sense of smell. It can
co-trimoxazole, furosemide, granulocyte-colony stimulating factor and
be either temporary or permanent.
minocycline.
Some of the drugs that can cause anosmia are ciprofloxacin, doxycycline,
enalapril, paroxetine and sparfloxacin.
Acute generalized exanthematous pustulosis
Arising on the face or intertriginous areas, acute generalized exanthematous Aphthous stomatitis
pustulosis (AGEP) is characterized by a rapidly evolving, widespread,
Aphthous stomatitis – also known as canker sores – is a common disease of
scarlatiniform eruption covered with hundreds of small superficial pustules.
the oral mucous membranes.
Often accompanied by a high fever, AGEP is most frequently associated
Arising as tiny, discrete or grouped, papules or vesicles, these painful
with acetaminophen, carbamazepine, penicillin and macrolide antibiotics,
lesions develop into small (2–5 mm in diameter), round, shallow ulcerations
and usually occurs within 24 hours of the drug exposure.
having a grayish, yellow base surrounded by a thin red border.
Located predominantly over the labial and buccal mucosae, these aphthae
heal without scarring in 10–14 days. Recurrences are common.
DESCRIPTIONS OF IMPORTANT REACTIONS Litt’s Drug Eruption & Reaction Manual
Baboon syndrome (SDRIFE) extremities, especially over the dorsa of the hands and extensor aspects of
Baboon syndrome or symmetric drug-related intertriginous and flexural the forearms. Lesions tend to spread peripherally and may involve the palms
exanthema (SDRIFE) is an unusual presentation of a drug eruption with a and trunk as well as the mucous membranes of the mouth and genitalia.
characteristic intertriginous distribution pattern. Several drugs have been Central healing and overlapping lesions often lead to arciform, annular and
implicated, notably mercury, nickel, heparin, aminophylline, pseudoephe- gyrate patterns. Lesions appear over the course of a week or 10 days and
drine, terbinafine, IVIG, various antibiotics (amoxicillin, ampicillin), and food resolve over the next two weeks.
additives. The following drugs have been most often associated with erythema
Originally described as a type of systemic contact dermatitis characterized multiforme: allopurinol, barbiturates, carbamazepine, estrogens/progestins,
by a pruritic exanthems involving the buttocks and major flexures – groins gold, lamotrigine, NSAIDs, penicillamine, phenytoin, sulfonamides, tetra-
and axillae, some investigators believe that this entity is a form of recall cycline, tolbutamide and valproic acid.
phenomenon. In children, it is important in the differential diagnosis of viral
exanthems. Erythema nodosum
Erythema nodosum is a cutaneous reaction pattern characterized by
Black tongue (lingua villosa nigra) erythematous, tender or painful subcutaneous nodules commonly distrib-
Black hairy tongue (BHT) represents a benign hyperplasia of the filiform uted over the anterior aspect of the lower legs, and occasionally elsewhere.
papillae of the anterior two-thirds of the tongue. More common in young women, erythema nodosum is often associated
These papillary elongations, usually associated with black, brown, or with increased estrogen levels as occurs during pregnancy and with the
yellow pigmentation attributed to the overgrowth of pigment-producing ingestion of oral contraceptives. It is also an occasional manifestation of
bacteria, may be as long as 2 cm. streptococcal infection, sarcoidosis, secondary syphilis, tuberculosis, certain
Occurring only in adults, BHT has been associated with the administration deep fungal infections, Hodgkin’s disease, leukemia, ulcerative colitis, and
of oral antibiotics, poor dental hygiene, and excessive smoking. radiation therapy and is often preceded by fever, fatigue, arthralgia, vomiting,
and diarrhea.
Bullous dermatitis The incidence of erythema nodosum due to drugs is low and it is
Bullous and vesicular drug eruptions are diseases in which blisters and impossible to distinguish clinically between erythema nodosum due to drugs
vesicles occur as a complication of the administration of drugs. Blisters are a and that caused by other factors.
well-known manifestation of cutaneous reactions to drugs. Some of the drugs that are known to occasion erythema nodosum are:
In many types of drug reactions, bullae and vesicles may be found in antibiotics, estrogens, amiodarone, gold, NSAIDs, oral contraceptives,
addition to other manifestations. Bullae are usually noted in: erythema sulfonamides, and opiates.
multiforme; Stevens–Johnson syndrome; toxic epidermal necrolysis; fixed
eruptions when very intense; urticaria; vasculitis; porphyria cutanea tarda; Exanthems
and phototoxic reactions (from furosemide and nalidixic acid). Tense, thick- Exanthems, commonly resembling viral rashes, represent the most common
walled bullae can be seen in bromoderma and iododerma as well as in type of cutaneous drug eruption. Described as maculopapular or morbilli-
barbiturate overdosage. form eruptions, these flat, barely raised, erythematous patches, from one to
Common drugs that cause bullous eruptions and bullous pemphigoid are: several millimeters in diameter, are usually bilateral and symmetrical. They
nadalol, penicillamine, piroxicam, psoralens, rifampin, clonidine, furosemide, commonly begin on the head and neck or upper torso and progress
diclofenac, mefenamic acid, and bleomycin. downward to the limbs. They may present or develop into confluent areas
and may be accompanied by pruritus and a mild fever.
DRESS syndrome
The DRESS syndrome is an acronym for Drug Rash with Eosinophilia and The exanthems caused by drugs can be classified as:
Systemic Symptoms. It is also known as the Drug-Induced Pseudolymphoma
and Drug Hypersensitivity Syndrome. l Morbilliform eruptions: fingernail-sized erythematous patches
The symptoms of DRESS syndrome usually begin 1 to 8 weeks after l Scarlatiniform eruptions: punctate, pinpoint, or pinhead-sized lesions in
exposure to the offending drug. Common causes include carbamazepine, erythematous areas that have a tendency to coalesce. Circumoral pallor
phenobarbital, phenytoin, terbinafine, and valproic acid. and the subsequent appearance of scaling may also be noted.
Erythema multiforme
Maculopapular drug eruptions usually fade with desquamation and,
Erythema multiforme is a relatively common, acute, self-limited, inflamma- occasionally, postinflammatory hyperpigmentation, in about 2 weeks. They
tory reaction pattern that is often associated with a preceding herpes invariably recur on rechallenge.
simplex or mycoplasma infection. Other causes are associated with Exanthems often have a sudden onset during the first 2 weeks of
connective tissue disease, physical agents, X-ray therapy, pregnancy and administration, except in cases of semisynthetic penicillin administration,
internal malignancies, to mention a few. In 50% of the cases, no cause can be when the exanthems frequently develop after the first 2 weeks following the
found. In a recent prospective study of erythema multiforme, only 10% initial dose.
were drug related.
The eruption rapidly occurs over a period of 12 to 24 hours. In about half The drugs most commonly associated with exanthems are: amoxicillin,
the cases there are prodromal symptoms of an upper respiratory infection ampicillin, bleomycin, captopril, carbamazepine, chlorpromazine, co-trimox-
accompanied by fever, malaise, and varying degrees of muscular and joint azole, gold, nalidixic acid, naproxen, phenytoin, penicillamine, and piroxicam.
pains.
Clinically, bluish-red, well-demarcated, macular, papular, or urticarial
lesions, as well as the classical ‘iris’ or ‘target lesions’, sometimes with central
vesicles, bullae, or purpura, are distributed preferentially over the distal
Litt’s Drug Eruption & Reaction Manual DESCRIPTIONS OF IMPORTANT REACTIONS
Exfoliative dermatitis While it is characteristically a side effect of hydantoin derivatives, it may

Exfoliative dermatitis is a rare but serious reaction pattern that is occur during the administration of phenobarbital, nifedipine, diltiazem and
characterized by erythema, pruritus and scaling over the entire body other medications.
(erythroderma).
Drug-induced exfoliative dermatitis usually begins a few weeks or longer Hand-foot syndrome
following the administration of a culpable drug. Beginning as erythematous, Hand-foot syndrome (also known as acral erythema, palmar-plantar
edematous patches, often on the face, it spreads to involve the entire erythrodysesthesia, palmoplantar erythrodysesthesia, palmar-plantar
integument. The skin becomes swollen and scarlet and may ooze a straw- erythema, and Bergdorf’s reaction) is a syndrome that is characterized by
colored fluid; this is followed in a few days by desquamation. well-demarcated painful erythema, edema, numbness and desquamation
High fever, severe malaise and chills, along with enlargement of lymph over the palms and soles that may develop following treatment with a variety
nodes, often coexist with the cutaneous changes. of chemotherapeutic agents including bleomycin, cisplatin, cyclophospha-
One of the most dangerous of all reaction patterns, exfoliative dermatitis mide, hydroxyurea, idarubicin, methotrexate, sorafenib, sunitinib, and
can be accompanied by any or all of the following: hypothermia, fluid and others. Tenderness involving the skin overlying the fingers and toes,
electrolyte loss, cardiac failure, and gastrointestinal hemorrhage. Death may followed by bulla formation and subsequent desquamation, often
supervene if the drug is continued after the onset of the eruption. Secondary supervenes.
infection often complicates the course of the disease. Once the active This side effect results when a small amount of the culpable drug leaks out
dermatitis has receded, hyperpigmentation as well as loss of hair and nails of the blood vessels, damaging tissues. This reaction predominates over the
may ensue. palms and soles, where eccrine glands are more numerous, and also as a
The following drugs, among others, can bring about exfoliative dermatitis: result of the increased friction and heat that extremities are exposed to
barbiturates, captopril, carbamazepine, cimetidine, furosemide, gold, through daily activities.
isoniazid, lithium, nitrofurantoin, NSAIDs, penicillamine, phenytoin, pyrazo-
lons, quinidine, streptomycin, sulfonamides, and thiazides. Lichenoid (lichen planus-like) eruptions
Lichenoid eruptions are so called because of their resemblance to lichen
Fixed eruption planus, a papulosquamous disorder that characteristically presents as
A fixed eruption is an unusual hypersensitivity reaction characterized by one multiple, discrete, violaceous, flat-topped papules, often polygonal in shape
or more well-demarcated erythematous plaques that recur at the same and which are extremely pruritic.
cutaneous (or mucosal) site or sites each time exposure to the offending Not infrequently, lichenoid lesions appear weeks or months following
agent occurs. The sizes of the lesions vary from a few millimeters to as much exposure to the responsible drug. As a rule, the symptoms begin to recede a
as 20 centimeters in diameter. Almost any drug that is ingested, injected, few weeks following the discontinuation of the drug.
inhaled, or inserted into the body can trigger this skin reaction. Common drug causes of lichenoid eruptions are: antimalarials, beta-
The eruption typically begins as a sharply marginated, solitary edematous blockers, chlorpropamide, furosemide, gold, methyldopa, phenothiazines,
papule or plaque – occasionally surmounted by a large bulla – which usually quinidine, thiazides, and tolazamide.
develops 30 minutes to 8 hours following the administration of a drug. If the
offending agent is not promptly eliminated, the inflammation intensifies, Lupus erythematosus
producing a dusky red, violaceous or brown patch that may crust, A reaction, clinically and pathologically resembling idiopathic systemic lupus
desquamate, or blister within 7 to 10 days. The lesions are rarely pruritic. erythematosus (SLE), has been reported in association with a large variety of
Favored sites are the hands, feet, face, and genitalia – especially the glans drugs. There is some evidence that drug-induced SLE, invariably accom-
penis. panied by a positive ANA reaction with 90% having antihistone antibodies,
The reason for the specific localization of the skin lesions in a fixed drug may have a genetically determined basis. These symptoms of SLE, a
eruption is unknown. The offending drug cannot be detected at the skin site. relatively benign form of lupus, recede within days or weeks following the
Certain drugs cause a fixed eruption at specific sites, for example, discontinuation of the responsible drug. Skin lesions occur in about 20% of
tetracycline and ampicillin often elicit a fixed eruption on the penis, whereas cases. Drugs cause fewer than 8% of all cases of SLE.
aspirin usually causes skin lesions on the face, limbs and trunk. The following drugs have been commonly associated with inducing,
Common causes of fixed eruptions are: ampicillin, aspirin, barbiturates, aggravating or unmasking SLE: beta-blockers, carbamazepine, chlorproma-
dapsone, metronidazole, NSAIDs, oral contraceptives, phenolphthalein, zine, estrogens, griseofulvin, hydralazine, isoniazid (INH), lithium, methyl-
phenytoin, quinine, sulfonamides, and tetracyclines. dopa, minoxidil, oral contraceptives, penicillamine, phenytoin
(diphenylhydantoin), procainamide, propylthiouracil, quinidine, and
Gingival hyperplasia/hypertrophy testosterone.
Gingival hyperplasia, a common, undesirable, non-allergic drug reaction
begins as a diffuse swelling of the interdental papillae. Onycholysis
Particularly prevalent with phenytoin therapy, gingival hyperplasia begins Onycholysis, the painless separation of the nail plate from the nail bed, is one
about 3 months after the onset of therapy, and occurs in 30 to 70% of of the most common nail disorders.
patients receiving it. The severity of the reaction is dose-dependent and The unattached portion, which is white and opaque, usually begins at the
children and young adults are more frequently affected. The most severe free margin and proceeds proximally, causing part or most of the nail plate to
cases are noted in young women. become separated. The attached, healthy portion of the nail, by contrast, is
In many cases, gingival hyperplasia is accompanied by painful and bleeding pink and translucent.
gums. There is often superimposed secondary bacterial gingivitis. This can be
so extensive that the teeth of the maxilla and mandible are completely Paresthesias
overgrown.
Paresthesias are abnormal neurological sensations such as burning, prickling,
numbness, pruritus, formication, or tingling, often described as ‘pins and
needles’ or of a limb being ‘asleep’. It is a symptom of partial damage to a Patients with a true photoallergy (the interaction of drug, light and the
peripheral nerve, as occurs from a head or spinal injury, lack of blood supply immune system), a less common form of drug-induced photosensitivity, are
to a nerve, or in many cases medications. often sensitive to UVB radiation, the so-called ‘burning rays’ at 290–320 nm.
Paresthesias can affect various parts of the body; hands, fingers, and feet Photoallergic reactions, unlike phototoxic responses, represent an immu-
are common sites but all areas are possibilities. nologic change and require a latent period of from 24 to 48 hours during
Scores of generic drugs have been reported to occasion paresthesias which sensitization occurs. They are not dose-related.
including alprazolam, allopurinol, buspirone, celecoxib, ciprofloxacin, If the photosensitizer acts internally, it is a photodrug reaction; if it acts
cyclosporine, enalapril, glipizine and many others. externally, it is photocontact dermatitis.
Drugs that are likely to cause phototoxic reactions are: amiodarone,
Pemphigus vulgaris nalidixic acid, various NSAIDs, phenothiazines (especially chlorpromazine),
Pemphigus vulgaris (PV) is a rare, serious, acute or chronic, blistering disease and tetracyclines (particularly demeclocycline).
involving the skin and mucous membranes. Photoallergic reactions may occur as a result of exposure to systemically-
Characterized by thin-walled, easily ruptured, flaccid bullae that are seen administered drugs such as griseofulvin, NSAIDs, phenothiazines, quinidine,
to arise on normal or erythematous skin and over mucous membranes, the sulfonamides, sulfonylureas, and thiazide diuretics as well as to external
lesions of PV appear initially in the mouth (in about 60% of the cases) and agents such as para-aminobenzoic acid (found in sunscreens), bithionol (used
then spread, after weeks or months, to involve the axillae and groin, scalp, in soaps and cosmetics), paraphenylenediamine, and others.
face and neck. The lesions may become generalized.
Because of their fragile roofs, the bullae rupture leaving painful erosions Pigmentation
and crusts may develop principally over the scalp. Drug-induced pigmentation on the skin, hair, nails, and mucous membranes
is a result of either melanin synthesis, increased lipofuscin synthesis, or post-
Peyronie’s disease inflammatory pigmentation.
First described in 1743 by the French surgeon, Francois de la Peyronie, Color changes, which can be localized or widespread, can also be a result
Peyronie’s disease is a rare, benign connective tissue disorder involving the of a deposition of bile pigments (jaundice), exogenous metal compounds, and
growth of fibrous plaques in the soft tissue of the penis. Beginning as a direct deposition of elements such as carotene or quinacrine.
localized inflammation, it often develops into a hardened scar. Affecting as Post-inflammatory pigmentation can follow a variety of drug-induced
many as 1% of men, it may cause deformity, pain, cord-like lesions, or inflammatory cutaneous reactions; fixed eruptions are known to leave a
abnormal curvature of the penis when erect. residual pigmentation that can persist for months.
It has been associated with several drugs, including all the adrenergic The following is a partial list of those drugs that can cause various
blocking agents (beta-blockers), methotrexate, colchicine and others. pigmentary changes: anticonvulsants, antimalarials, cytostatics, hormones,
metals, tetracyclines, phenothiazine tranquilizers, psoralens and amiodarone.
Photosensitivity
Pityriasis rosea-like eruption
A photosensitive reaction is a chemically induced change in the skin that
makes an individual unusually sensitive to electromagnetic radiation (light). Pityriasis rosea, commonly mistaken for ringworm, is a unique disorder that
On absorbing light of a specific wavelength, an oral, injected or topical drug usually begins as a single, large, round or oval pinkish patch known as the
may be chemically altered to produce a reaction ranging from macules and ‘mother’ or ‘herald’ patch. The most common sites for this solitary lesion
papules, vesicles and bullae, edema, urticaria, or an acute eczematous are the chest, the back, or the abdomen. This is followed in about 2 weeks
reaction. by a blossoming of small, flat, round or oval, scaly patches of similar color,
Any eruption that is prominent on the face, the dorsa of the hands, the ‘V’ each with a central collarette scale, usually distributed in a Christmas tree
of the neck, and the presternal area should suggest an adverse reaction to pattern over the trunk and, to a lesser degree, the extremities. This eruption
light. The distribution is the key to the diagnosis. seldom itches and usually limits itself to areas from the neck to the knees.
Initially the eruption, which consists of erythema, edema, blisters, While the etiology of idiopathic pityriasis rosea is unknown, various
weeping and desquamation, involves the forehead, rims of the ears, the medications have been reported to give rise to this disorder. These include:
nose, the malar eminences and cheeks, the sides and back of the neck, the barbiturates, beta-blockers, bismuth, captopril, clonidine, gold, griseofulvin,
extensor surfaces of the forearms and the dorsa of the hands. These isotretinoin, labetalol, meprobamate, metronidazole, penicillin, and
reactions commonly spare the shaded areas: those under the chin, under the tripelennamine.
nose, behind the ears and inside the fold of the upper eyelids. There is In drug-induced pityriasis rosea, the ‘herald patch’ is usually absent, and
usually a sharp cut-off at the site of jewelry and at clothing margins. All light- the eruption will often not follow the classic pattern.
exposed areas need not be affected equally.
There are two main types of photosensitive reactions: the phototoxic and Pruritus
the photoallergic reaction. Generalized itching, without any visible signs, is one of the least common
Phototoxic reactions, the most common type of drug-induced photo- adverse reactions to drugs. More frequently than not, drug-induced itching –
sensitivity, resemble an exaggerated sunburn and occur within 5 to 20 hours moderate or severe – is fairly generalized.
after the skin has been exposed to a photosensitizing substance and light of For most drugs it is not known in what way they elicit pruritus; some
the proper wavelength and intensity. It is not a form of allergy – prior drugs can cause itching directly or indirectly through cholestasis. Pruritus
sensitization is not required – and, theoretically, could occur in anyone given may develop by different pathogenetic mechanisms: allergic, pseudoallergic
enough drug and light. Phototoxic reactions are dose-dependent both for (histamine release), neurogenic, by vasodilatation, cholestatic effect, and
drug and sunlight. Patients with phototoxicity reactions are commonly others.
sensitive to ultraviolet A (UVA radiation), the so-called ‘tanning rays’ at 320– A partial list of those drugs that can cause pruritus are as follows: aspirin,
400 nm. Phototoxic reactions may cause onycholysis, as the nailbed is NSAIDs, penicillins, sulfonamides, chloroquine, ACE-inhibitors, amiodarone,
particularly susceptible because of its lack of melanin protection. nicotinic acid derivatives, lithium, bleomycin, tamoxifen, interferons, gold,
Litt’s Drug Eruption & Reaction Manual DESCRIPTIONS OF IMPORTANT REACTIONS
penicillamine, methoxsalen and isotretinoin. Raynaud’s phenomenon

Raynaud’s phenomenon is the paroxysmal, cold-induced constriction of small
Pseudolymphoma arteries and arterioles of the fingers and, less often, the toes.
Pseudolymphoma is not a specific disease. It is an inflammatory response to Although estimates vary, recent surveys show that Raynaud’s phenom-
various stimuli – known or unknown – that results in a lymphomatous- enon may affect 5 to 10 percent of the general population in the United
appearing, but benign, accumulation of inflammatory cells. It may resemble States. Occurring more frequently in women, Raynaud’s phenomenon is
true lymphoma clinically and histologically. Localized, nodular pseudolym- characterized by blanching, pallor, and cyanosis. In severe cases, secondary
phomas typically mimic B-cell lymphoma. changes may occur: thinning and ridging of the nails, telangiectases of the nail
The following drugs, among others, are known to occasion pseudolym- folds, and, in the later stages, sclerosis and atrophy of the digits.
phoma: alprazolam, carbamazepine, co-trimoxazole, gold, lamotrigine,
lithium, methotrexate, etc. Rhabdomyolysis
Rhabdomyolysis is the breakdown of muscle fibers, the result of skeletal
Pseudoporphyria muscle injury, that leads to the release of potentially toxic intracellular
Pseudoporphyria is an uncommon, reversible, photoinduced, cutaneous contents into the plasma. The causes are diverse: muscle trauma from
bullous disorder with clinical, histologic and immunofluorescent similarities vigorous exercise, electrolyte imbalance, extensive thermal burns, crush
to porphyria cutanea tarda but without the accompanying biochemical injuries, infections, various toxins and drugs, and a host of other factors.
porphyrin abnormalities. Rhabdomyolysis can result from direct muscle injury by myotoxic drugs
It is commonly seen as localized bullae and skin fragility on sun-exposed such as cocaine, heroin and alcohol. About 10–40% of patients with
skin, often on the dorsum of the hands and fingers. While pseudoporphyria rhabdomyolysis develop acute renal failure.
has been linked with numerous causes, including chronic renal failure, The classic triad of symptoms of rhabdomyolysis is muscle pain, weakness
dialysis, and ultraviolet radiation, several medications, primarily naproxen and dark urine. Most frequently, the involved muscle groups are those of the
and other nonsteroidal inflammatory drugs, have been reported to trigger back and lower calves. The primary diagnostic indicator of this syndrome is
this reaction pattern. Blue/gray eye color appears to be an independent risk significantly elevated serum creatine phosphokinase.
factor for the development of pseudoporphyria. Some of the drugs that have been reported to cause rhabdomyolysis are
salicylates, amphotericin, quinine, statin drugs, SSRIs, theophylline,
Psoriasis and amphetamines.
Many drugs, as a result of their pharmacological action, have been implicated
in the precipitation or exacerbation of psoriasis or psoriasiform eruptions. Stevens-Johnson syndrome
Psoriasis is a common, chronic, papulosquamous disorder of unknown The Stevens-Johnson syndrome (erythema multiforme major), a severe and
etiology with characteristic histopathological features and many biochemical, occasionally fatal variety of erythema multiforme, has an abrupt onset and is
physiological, and immunological abnormalities. accompanied by any or all of the following: fever, myalgia, malaise, headache,
Drugs that can precipitate psoriasis are, among others, beta-blockers and arthralgia, ocular involvement, with occasional bullae and erosions covering
lithium. Drugs that are reported to aggravate psoriasis are antimalarials, less than 10% of the body surface. Painful stomatitis is an early and
beta-blockers, lithium, NSAIDs, quinidine, and photosensitizing drugs. The conspicuous symptom. Hemorrhagic bullae may appear over the lips, mouth
effect and extent of these drug-induced psoriatic eruptions are dose- and genital mucous membranes. Patients are often acutely ill with high fever.
dependent. The course from eruption to the healing of the lesions may extend up to six
weeks.
Purpura The following drugs have been most often associated with Stevens-
Purpura, a result of hemorrhage into the skin, can be divided into Johnson syndrome: allopurinol, barbiturates, carbamazepine, estrogens/
thrombocytopenic purpura and non-thrombocytopenic purpura (vascular progestins, gold, lamotrigine, NSAIDs, penicillamine, phenytoin, sulfona-
purpura). Both thrombocytopenic and vascular purpura may be due to mides, tetracycline, tolbutamide, and valproic acid.
drugs, and most of the drugs producing purpura may do so by giving rise to
vascular damage and thrombocytopenia. In both types of purpura, allergic or Tinnitus
toxic (nonallergic) mechanisms may be involved. Tinnitus (from the Latin word to tinkle or ring like a bell) is the perception of
Some drugs combine with platelets to form an antigen, stimulating sound—ringing, buzzing, hissing, humming, whistling, whining, roaring, or
formation of antibody to the platelet–drug combination. Thus, the drug ticking, clicking, banging, beeping, pulsating—in the human ear, when none
appears to act as a hapten; subsequent antigen–antibody reaction causes exists. It has also been described as a ‘whooshing’ sound, like wind or waves,
platelet destruction leading to thrombocytopenia. ‘crickets’ or ‘tree frogs’ or ‘locusts.’ To some it’s a chirping, clanging, sizzling,
The purpuric lesions are usually more marked over the lower portions of rumbling, or a dreadful shrieking noise. And it can be like rushing water,
the body, notably the legs and dorsal aspects of the feet in ambulatory breaking glass or chain saws running. Nearly 40 million Americans suffer
patients. from this disorder.
Other drug-induced cutaneous reactions – erythema multiforme, There are more than 200 drugs listed in the Litt’s Drug Eruption &
erythema nodosum, fixed eruption, necrotizing vasculitis, and others – can Reaction Database that have been reported to trigger tinnitus, the more
have a prominent purpuric component. common being aspirin, quinine, aminoglycoside antibiotics, cytotoxic drugs,
A whole host of drugs can give rise to purpura, the most common being: diuretics, and NSAIDs.
NSAIDs, thiazide diuretics, phenothiazines, cytostatics, gold, penicillamine,
hydantoins, thiouracils, and sulfonamides. Toxic epidermal necrolysis (TEN)
Also known as Lyell’s syndrome, toxic epidermal necrolysis is a rare, serious,
acute exfoliative, bullous eruption of the skin and mucous membranes that
usually develops as a reaction to diverse drugs. TEN can also be a result of a
bacterial or viral infection and can develop after radiation therapy or with a variety of small, palpable purpuric lesions most frequently distributed
vaccinations. over the lower extremities: urticaria-like lesions, small ulcerations, and
In the drug-induced form of TEN, a morbilliform eruption accompanied occasional hemorrhagic vesicles and pustules. The basic process involves an
by large red, tender areas of the skin will develop shortly after the drug has immunologically mediated response to antigens that result in vessel wall
been administered. This progresses rapidly to blistering, and a widespread damage.
exfoliation of the epidermis develops dramatically over a very short period Beginning as small macules and papules, they ultimately eventuate into
accompanied by high fever. The hairy parts of the body are usually spared. purpuric lesions and, in the more severe cases, into hemorrhagic blisters and
The mucous membranes and eyes are often involved. frank ulcerations. A polymorphonuclear infiltrate and fibrinoid changes in the
The clinical picture resembles an extensive second-degree burn; the small dermal vessels characterize the vasculitic reaction.
patient is acutely ill. Fatigue, vomiting, diarrhea and angina are prodromal Drugs that are commonly associated with vasculitis are: ACE-inhibitors,
symptoms. In a few hours the condition becomes grave. amiodarone, ampicillin, cimetidine, coumadin, furosemide, hydantoins,
TEN is a medical emergency and unless the offending agent is hydralazine, NSAIDs, pyrazolons, quinidine, sulfonamides, thiazides, and
discontinued immediately, the outcome may be fatal in the course of a thiouracils.
few days.
Drugs that are the most common cause of TEN are: allopurinol, Vertigo
ampicillin, amoxicillin, carbamazepine, NSAIDs, phenobarbital, pentamidine, Vertigo, a specific type of dizziness, is a feeling of unsteadiness. It is the
phenytoin (diphenylhydantoin), pyrazolons, and sulfonamides. sensation of spinning or swaying while actually remaining stationary with
respect to the surroundings. It is a result of either motion sickness, a viral
Urticaria infection of the organs of balance, low blood sugar, or medications. It is a
Urticaria induced by drugs is, after exanthems, the second most common symptom of multiple sclerosis, carbon monoxide poisoning, and Meniere’s
type of drug reaction. Urticaria, or hives, is a vascular reaction of the skin disease.
characterized by pruritic, erythematous wheals. These welts – or wheals – Vertigo is one of the most common health problems in adults. According
caused by localized edema, can vary in size from one millimeter in diameter to the National Institutes of Health, about 40% of people in the United
to large palm-sized swellings, favor the covered areas (trunk, buttocks, States experience vertigo at least once during their lifetime. Prevalence is
chest), and are, more often than not, generalized. Urticaria usually develops higher in women and increases with age.
within 36 hours following the administration of the responsible drug. Classes of drugs that have been reported to trigger vertigo include,
Individual lesions rarely persist for more than 24 hours. aminoglycoside antibiotics, antihypertensives, diuretics, vasodilators, phe-
Urticaria may be the only symptom of drug sensitivity, or it may be a nothiazines, tranquilizers, antidepressants, anticonvulsants, hypnotics,
concomitant or followed by the manifestations of serum sickness. Urticaria analgesics, alcohol, caffeine, and tobacco.
may be accompanied by angioedema of the lips or eyelids. It may, on rare
occasions, progress to anaphylactoid reactions or to anaphylaxis. Xerostomia
The following are the most common causes of drug-induced urticaria: Xerostomia is a dryness of the oral cavity that makes speaking, chewing and
antibiotics, notably penicillin (more commonly following parenteral admin- swallowing difficult. Some people also experience changes in taste and
istration than by ingestion), barbiturates, captopril, levamisole, NSAIDs, salivary gland enlargement. Lack of saliva may predispose one to oral
quinine, rifampin, sulfonamides, thiopental, and vancomycin. infection, such as candidiasis, and increase the risk of dental caries.
Resulting from a partial or complete absence of saliva production,
Vasculitis xerostomia can be caused by more than 400 generic drugs.
Drug-induced cutaneous necrotizing vasculitis, a clinicopathologic process
characterized by inflammation and necrosis of blood vessels, often presents
DRUGS THAT CAUSE IMPORTANT REACTIONS
Acanthosis nigricans Cyclosporine Interferon Alfa Propafenone

Amprenavir Dabrafenib Interferon Beta Propranolol
Azathioprine Daclizumab Ipilimumab Propylthiouracil
Diethylstilbestrol Dactinomycin Irinotecan Psoralens
Estrogens Danazol Isoniazid Pyrazinamide
Fusidic Acid Dantrolene Isotretinoin Pyridoxine
Heroin Dapsone Ivacaftor Quinidine
Insulin Dasatinib Ixazomib Quinine
Mechlorethamine Deflazacort Lamotrigine Ramipril
Methsuximide Demeclocycline Lansoprazole Riboflavin
Methyltestosterone Dexamethasone Lapatinib Rifampin
Niacin Dexlansoprazole Leflunomide Rifapentine
Niacinamide Diazepam Lenalidomide Risperidone
Oral Contraceptives Diltiazem Letrozole Ritonavir
Palifermin Disulfiram Leucovorin Rufinamide
Prednisolone Doxycycline Levonorgestrel Ruxolitinib
Prednisone Duloxetine Lisdexamfetamine Saquinavir
Somatropin Durvalumab Lithium Sertraline
Thioridazine Efalizumab Lopinavir Sibutramine
Tryptophan Eflornithine Maprotiline Simvastatin
Acneform lesions Epoetin Alfa MDMA Sirolimus
Acamprosate Erlotinib Medroxyprogesterone Smallpox Vaccine
Acyclovir Erythromycin Mephenytoin Sodium Oxybate
Adalimumab Escitalopram Mesalamine Sorafenib
Adapalene Esmolol Methotrexate Sparfloxacin
Afatinib Esomeprazole Methoxsalen Stanozolol
Alosetron Estazolam Methyltestosterone Sunitinib
Alprazolam Estramustine Minoxidil Tacrine
Aminolevulinic Acid Estrogens Mometasone Temsirolimus
Androstenedione Eszopiclone Mycophenolate Teriflunomide
Aprepitant Etanercept Nabumetone Testosterone
Aripiprazole Ethionamide Nadolol Tetracycline
Atorvastatin Everolimus Nafarelin Tiagabine
Azathioprine Famotidine Naltrexone Tibolone
Basiliximab Felbamate Nandrolone Tizanidine
Bedaquiline Fenoprofen Naratriptan Topiramate
Belatacept Finasteride Necitumumab Trametinib
Betamethasone Fluconazole Nefazodone Trastuzumab
Bevacizumab Fluorides Nicotine Tretinoin
Bexarotene Fluorouracil Nilotinib Trioxsalen
Bosutinib Fluoxetine Nimodipine Triptorelin
Brimonidine Fluoxymesterone Nisoldipine Ulipristal
Budesonide Fluvoxamine Nitrofurantoin Valdecoxib
Bupropion Folic Acid Nivolumab Vandetanib
Buserelin Follitropin Alfa/Beta Nizatidine Vemurafenib
Buspirone Fosphenytoin Olsalazine Venlafaxine
Cabergoline Gabapentin Oral Contraceptives Verapamil
Capecitabine Ganciclovir Osimertinib Vinblastine
Carbamazepine Gefitinib Oxcarbazepine Vinorelbine
Ceritinib Gemcitabine Paclitaxel Vorinostat
Cetirizine Gestrinone Panitumumab Zalcitabine
Cetuximab Glatiramer Panobinostat Zaleplon
Chloral Hydrate Gold & Gold Compounds Pantoprazole Zidovudine
Chlorotrianisene Goserelin Paroxetine Hydrochloride Zolpidem
Cidofovir Granulocyte Colony- Pentostatin Zonisamide
Ciprofloxacin Stimulating Factor (G-CSF) Phenobarbital Acute febrile neutrophilic
Cisplatin Grepafloxacin Phenylbutazone dermatosis
Clobetasol Halothane Phenytoin Abacavir
Clofazimine Heroin Pimecrolimus Aceclofenac
Clomipramine Histrelin Ponatinib Aldesleukin
Cobimetinib Hyaluronic Acid Potassium Iodide Allopurinol
Crofelemer Hydroquinone Prednisolone Amoxapine
Cyanocobalamin Imatinib Prednisone Azacitidine
Cyclophosphamide Infliximab Progestins Azathioprine
DRUGS THAT CAUSE IMPORTANT REACTIONS Litt’s Drug Eruption & Reaction Manual
BCG Vaccine Carbimazole Levofloxacin Aspirin

Bortezomib Cefaclor Lincomycin Atorvastatin
Celecoxib Cefazolin Lindane Azelastine
Chloroquine Cefepime Lopinavir Betaxolol
Ciprofloxacin Cefotaxime Meloxicam Candesartan
Citalopram Ceftazidime Meropenem Captopril
Clindamycin Ceftriaxone Metamizole Carbamazepine
Clofazimine Cefuroxime Methimazole Cetirizine
Clozapine Celecoxib Methoxsalen Chlorhexidine
Co-Trimoxazole Cephalexin Methylphenidate Clindamycin
Cytarabine Cephradine Methylprednisolone Clopidogrel
Dasatinib Cetirizine Metronidazole Cocaine
Diazepam Chloramphenicol Mexiletine Cyclobenzaprine
Doxycycline Chloroquine Midodrine Doxorubicin
Esomeprazole Chlorzoxazone Mifepristone Enalapril
Furosemide Ciprofloxacin Minocycline Eslicarbazepine
Glucagon Clindamycin Morphine Etidronate
Granulocyte Colony- Clopidogrel Moxifloxacin Fluoxetine
Stimulating Factor (G-CSF) Cloxacillin Naltrexone Fluvoxamine
Hydralazine Clozapine Nifedipine Fosinopril
Imatinib Co-Trimoxazole Nimesulide Grepafloxacin
Infliximab Codeine Nivolumab Hydroxychloroquine
Influenza Vaccine Cytarabine Nystatin Indomethacin
Ipilimumab Dalteparin Olanzapine Interferon Alfa
Isotretinoin Dapsone Omeprazole Isotretinoin
Ixazomib Daptomycin Pemetrexed Losartan
Lenalidomide Dexamethasone Phenobarbital Methimazole
Minocycline Dextromethorphan Phenytoin Nefazodone
Mitoxantrone Dihydrocodeine Piperacillin/Tazobactam Nitroglycerin
Nilotinib Diltiazem Piroxicam Paroxetine Hydrochloride
Nitrofurantoin Diphenhydramine Prednisolone Penicillamine
Nivolumab Docetaxel Pristinamycin Phenylbutazone
Norfloxacin Doripenem Progestins Phenytoin
Ofloxacin Doxycycline Propafenone Propofol
Omeprazole Enzalutamide Propoxyphene Propylthiouracil
Oral Contraceptives Epoetin Alfa Pseudoephedrine Ramipril
Pandemic Influenza Vaccine Erlotinib Pyrazinamide Rifabutin
(H1N1) Ertapenem Pyrimethamine Rifaximin
PEG-Interferon Erythromycin Quetiapine Rimantadine
Perphenazine Etanercept Quinidine Ritonavir
Phenylbutazone Etodolac Ranibizumab Rivastigmine
Pneumococcal Vaccine Famotidine Ranitidine Sonidegib
Propylthiouracil Fenofibrate Ranolazine Sulindac
Quinupristin/Dalfopristin Fexofenadine Rifabutin Terbinafine
Ribavirin Finasteride Rifampin Tiagabine
Sulfamethoxazole Flucloxacillin Ritodrine Tiopronin
Sulfasalazine Fluconazole Rivaroxaban Topiramate
Ticagrelor Furosemide Sertraline Valrubicin
Tretinoin Galantamine Simvastatin Venlafaxine
Verapamil Gefitinib Sorafenib Vismodegib
Vorinostat Hydrochlorothiazide Streptomycin Voriconazole
Acute generalized Hydroxychloroquine Sulfamethoxazole Zalcitabine
exanthematous pustulosis Hydroxyzine Sulfasalazine Alopecia
Acarbose Ibuprofen Teicoplanin Abemaciclib
Acetaminophen Icodextrin Telavancin Acetohexamide
Acetazolamide Imatinib Terazosin Acitretin
Aldesleukin Imipenem/Cilastatin Terbinafine Acyclovir
Allopurinol Immune Globulin IV Tetrazepam Adalimumab
Amoxapine Infliximab Thalidomide Ado-Trastuzumab Emtansine
Amoxicillin Influenza Vaccine Thallium Afatinib
Amphotericin B Iodixanol Ticlopidine Aflibercept
Ampicillin Iohexol Tigecycline Albendazole
Aspirin Ioversol Tocilizumab Aldesleukin
Atovaquone/Proguanil Isoniazid Valdecoxib Alectinib
Azathioprine Isotretinoin Valproic Acid Alitretinoin
Azithromycin Itraconazole Vancomycin Allopurinol
Bacampicillin Ketoconazole Varenicline Altretamine
Bendamustine Lamivudine Vemurafenib Amantadine
Benznidazole Lamotrigine Zidovudine Amiloride
Bupropion Lansoprazole Ageusia Aminolevulinic Acid
Carbamazepine Levetiracetam Acarbose Aminosalicylate Sodium
Litt’s Drug Eruption & Reaction Manual DRUGS THAT CAUSE IMPORTANT REACTIONS
Amiodarone Cyclosporine Gabapentin Lovastatin

Amitriptyline Cytarabine Gadodiamide Maprotiline
Amlodipine Dabrafenib Ganciclovir Mebendazole
Amoxapine Dacarbazine Gefitinib Mechlorethamine
Anagrelide Daclatasvir Gemcitabine Meclofenamate
Anastrozole Daclizumab Gentamicin Medroxyprogesterone
Androstenedione Dactinomycin Glatiramer Mefloquine
Anidulafungin Dalteparin Gold & Gold Compounds Meloxicam
Aprepitant Danazol Goserelin Melphalan
Arsenic Dasatinib Granisetron Memantine
Aspirin Daunorubicin Granulocyte Colony- Mercaptopurine
Astemizole Decitabine Stimulating Factor (G-CSF) Mesalamine
Atenolol Deferasirox Grepafloxacin Metformin
Atorvastatin Deflazacort Haloperidol Methimazole
Atovaquone/Proguanil Degarelix Halothane Methotrexate
Atropine Sulfate Delavirdine Heparin Methyltestosterone
Axitinib Desipramine Hepatitis B Vaccine Methysergide
Azathioprine Dexamethasone Human Papillomavirus Vaccine Metoprolol
Belatacept Diazoxide (Bivalent) Mexiletine
Belinostat Diclofenac Hydroxychloroquine Minocycline
Bendamustine Dicumarol Hydroxyurea Minoxidil
Benznidazole Didanosine Hyoscyamine Mirtazapine
Betamethasone Diethylpropion Ibandronate Mitomycin
Betaxolol Diflunisal Ibritumomab Mitotane
Bevacizumab Diltiazem Ibuprofen Mitoxantrone
Bexarotene Dimethyl Fumarate Idarubicin Mizoribine
Bezafibrate Docetaxel Ifosfamide Moexipril
Bicalutamide Donepezil Imatinib Mycophenolate
Bismuth Doxazosin Imipramine Nabumetone
Bleomycin Doxepin Imiquimod Nadolol
Botulinum Toxin (A & B) Doxorubicin Immune Globulin IV Nalidixic Acid
Brentuximab Vedotin Duloxetine Indinavir Naltrexone
Brinzolamide Eculizumab Indomethacin Naproxen
Bromocriptine Efavirenz Infliximab Naratriptan
Budesonide Eflornithine Interferon Alfa Nefazodone
Bupropion Eltrombopag Interferon Beta Neratinib
Buspirone Enalapril Ipilimumab Nifedipine
Busulfan Enoxaparin Ipratropium Nilotinib
Cabazitaxel Entecavir Irinotecan Nimodipine
Cabergoline Epinephrine Isavuconazonium Sulfate Nintedanib
Cabozantinib Epirubicin Isoniazid Nisoldipine
Calcipotriol Epoetin Alfa Isotretinoin Nitisinone
Capecitabine Eribulin Itraconazole Nitrofurantoin
Captopril Erlotinib Ixabepilone Nivolumab
Carbamazepine Erythromycin Ixazomib Nortriptyline
Carboplatin Escitalopram Ketoconazole Octreotide
Carmustine Eslicarbazepine Ketoprofen Olanzapine
Carvedilol Estramustine Ketorolac Olaparib
Celecoxib Estrogens Labetalol Olaratumab
Certolizumab Eszopiclone Lamivudine Omacetaxine
Cetirizine Etanercept Lamotrigine Omalizumab
Cetuximab Ethambutol Lanreotide Omeprazole
Cevimeline Ethionamide Lansoprazole Oral Contraceptives
Chlorambucil Etoposide Lapatinib Oxaliplatin
Chloramphenicol Everolimus Leflunomide Oxerutins
Chlordiazepoxide Evolocumab Lenvatinib Paclitaxel
Chlorpropamide Exemestane Letrozole Palbociclib
Cidofovir Febuxostat Leucovorin Panitumumab
Cimetidine Fenofibrate Leuprolide Panobinostat
Cisplatin Fenoprofen Levamisole Pantoprazole
Citalopram Fingolimod Levobetaxolol Paricalcitol
Clarithromycin Flecainide Levobunolol Paroxetine Hydrochloride
Clofibrate Fluconazole Levodopa Pasireotide
Clomiphene Fludarabine Levothyroxine Pazopanib
Clomipramine Fluorouracil Liothyronine PEG-Interferon
Clonazepam Fluoxetine Lisinopril Pegvisomant
Clonidine Fluoxymesterone Lithium Pembrolizumab
Cobimetinib Flurbiprofen Lomustine Pemetrexed
Colchicine Fluvoxamine Lopinavir Penicillamine
Crizotinib Foscarnet Loratadine Pentosan
Cyclophosphamide Fulvestrant Losartan Pentostatin
Peplomycin Topotecan Bevacizumab Diclofenac

Pergolide Trabectedin Bezafibrate Dicumarol
Pertuzumab Trametinib Bismuth Diethylstilbestrol
Phentermine Trastuzumab Bleomycin Diflunisal
Phenytoin Trazodone Brivaracetam Dihydrocodeine
Piroxicam Trifluridine & Tipiracil Brompheniramine Diltiazem
Pramipexole Trimethadione Budesonide Dimenhydrinate
Prazosin Trimipramine Bupropion Diphenhydramine
Prednisolone Triptorelin Butabarbital Dipyridamole
Prednisone Ursodiol Canagliflozin Disulfiram
Procarbazine Valdecoxib Candesartan Dofetilide
Propafenone Valproic Acid Captopril Doxazosin
Propranolol Vandetanib Carbamazepine Doxorubicin
Propylthiouracil Vasopressin Carisoprodol Doxycycline
Protriptyline Vemurafenib Carvedilol Dronedarone
Pyridostigmine Venlafaxine Cefaclor Droperidol
Quetiapine Verapamil Cefadroxil Dutasteride
Quinacrine Vinblastine Cefixime Efalizumab
Quinapril Vincristine Cefoxitin Enalapril
Quinidine Vinorelbine Cefprozil Enoxaparin
Rabeprazole Vismodegib Ceftazidime Epoetin Alfa
Raltitrexed Vitamin A Ceftriaxone Erythromycin
Ramipril Voriconazole Cefuroxime Esomeprazole
Regorafenib Vorinostat Celecoxib Estramustine
Ribavirin Warfarin Cephalexin Estrogens
Ribociclib Zaleplon Certolizumab Etanercept
Riluzole Zidovudine Cetirizine Ethambutol
Risperidone Ziprasidone Chloral Hydrate Etidronate
Ritonavir Zoledronate Chlorambucil Etodolac
Rituximab Zonisamide Chloramphenicol Etomidate
Rivastigmine Zoster Vaccine Chlordiazepoxide Etoricoxib
Rofecoxib Angioedema Chloroquine Everolimus
Ropinirole Acetaminophen Chlorpheniramine Ezetimibe
Rucaparib Acetylcysteine Chlorpromazine Famotidine
Selenium Acitretin Chlorpropamide Febuxostat
Sertraline Acyclovir Chlorthalidone Felodipine
Sodium Oxybate Adalimumab Chlorzoxazone Fenoprofen
Sonidegib Albendazole Cilazapril Fentanyl
Sorafenib Aldesleukin Cimetidine Fluconazole
Sotalol Alefacept Cinoxacin Fluorouracil
Sparfloxacin Alemtuzumab Ciprofloxacin Fluoxetine
Spinosad Alendronate Cisplatin Fluphenazine
Spironolactone Aliskiren Clarithromycin Flurbiprofen
Strontium Ranelate Allopurinol Clemastine Fluvoxamine
Sulfasalazine Alogliptin Clonazepam Fosinopril
Sulfisoxazole Alprazolam Clonidine Fulvestrant
Sulindac Alteplase Clopidogrel Glatiramer
Sunitinib Aminoglutethimide Cloxacillin Glucagon
Tacrine Aminosalicylate Sodium Clozapine Gold & Gold Compounds
Tacrolimus Amiodarone Co-Trimoxazole Griseofulvin
Tamoxifen Amitriptyline Cocaine Haloperidol
Tegafur/Gimeracil/Oteracil Amlodipine Codeine Halothane
Temozolomide Amodiaquine Cromolyn Heparin
Temsirolimus Amoxicillin Cyanocobalamin Hepatitis B Vaccine
Teniposide Ampicillin Cyclamate Heroin
Terbinafine Ampicillin/Sulbactam Cyclobenzaprine Histrelin
Terfenadine Anidulafungin Cyclophosphamide Hyaluronic Acid
Teriflunomide Anthrax Vaccine Cyclosporine Hydralazine
Testosterone Ascorbic Acid Cyproheptadine Hydrochlorothiazide
Thalidomide Asenapine Dacarbazine Hydrocortisone
Thallium Asparaginase Danazol Hydromorphone
Thioguanine Aspartame Darunavir Hydroxychloroquine
Thiotepa Aspirin Dasabuvir/Ombitasvir/ Hydroxyzine
Tiagabine Atorvastatin Paritaprevir/Ritonavir Ibritumomab
Timolol Atracurium Daunorubicin Ibuprofen
Tinzaparin Azatadine Deferoxamine Icatibant
Tiopronin Azathioprine Deflazacort Iloperidone
Tizanidine Azithromycin Delavirdine Imidapril
Tocainide Aztreonam Desipramine Imiglucerase
Tolcapone Benazepril Dexchlorpheniramine Imipenem/Cilastatin
Topiramate Benznidazole Diazepam Imipramine
Imiquimod Nifedipine Sparfloxacin Methoxsalen

Indapamide Nimesulide Streptokinase Midodrine
Indomethacin Nitrofurantoin Streptomycin Nifedipine
Infliximab Ofloxacin Sulfadoxine Propofol
Insulin Olanzapine Sulfamethoxazole Pyrazinamide
Interferon Alfa Olmesartan Sulfasalazine Terbinafine
Iodixanol Omalizumab Sulfisoxazole Uracil/Tegafur
Iothalamate Omeprazole Sulindac Zinc
Irbesartan Oral Contraceptives Sumatriptan Aphthous stomatitis
Isoniazid Oritavancin Tacrolimus Afatinib
Isotretinoin Oxaliplatin Tartrazine Aldesleukin
Itraconazole Oxaprozin Telithromycin Amodiaquine
Ivacaftor Paclitaxel Telmisartan Amoxicillin
Ivermectin Pamidronate Tenecteplase Anagrelide
Ixekizumab Panitumumab Terbinafine Artesunate
Ketoconazole Pantoprazole Terfenadine Asparaginase
Ketoprofen Paroxetine Hydrochloride Teriflunomide Aspirin
Ketorolac PEG-Interferon Tetracycline Azathioprine
Labetalol Pegaptanib Thiamine Azelastine
Lacosamide Pegaspargase Thiopental Aztreonam
Lamivudine Penicillin G Thioridazine Belatacept
Lamotrigine Penicillin V Thiotepa Benznidazole
Ledipasvir & Sofosbuvir Pentagastrin Ticlopidine Bupropion
Lepirudin Pentobarbital Tinidazole Candesartan
Levamisole Pentoxifylline Tiopronin Captopril
Levofloxacin Perflutren Tiotropium Cefaclor
Levothyroxine Perindopril Tocilizumab Certolizumab
Lidocaine Phenelzine Tolmetin Cetuximab
Linezolid Phenobarbital Tositumomab & Iodine131 Cisplatin
Lisinopril Phenolphthalein Tosufloxacin Co-Trimoxazole
Lithium Phenylbutazone Tramadol Cyclophosphamide
Lixisenatide Phenytoin Trandolapril Cyclosporine
Loratadine Pioglitazone Trastuzumab Delavirdine
Losartan Piroxicam Trazodone Diclofenac
Lurasidone Potassium Iodide Trifluoperazine Docetaxel
MDMA Prasugrel Trimeprazine Doxepin
Mebendazole Praziquantel Trimetrexate Doxorubicin
Mebeverine Prazosin Tripelennamine Epirubicin
Mechlorethamine Prilocaine Triprolidine Erlotinib
Meclizine Primaquine Triptorelin Everolimus
Meclofenamate Pristinamycin Troleandomycin Exemestane
Mefenamic Acid Procainamide Trospium Fenoprofen
Meloxicam Procarbazine Trovafloxacin Fluorides
Melphalan Progestins Urokinase Fluorouracil
Meperidine Promethazine Valsartan Fluoxetine
Mephenytoin Propafenone Vancomycin Gold & Gold Compounds
Mephobarbital Propofol Vardenafil Hepatitis B Vaccine
Mepivacaine Propranolol Vedolizumab Imatinib
Meprobamate Propylthiouracil Venlafaxine Imiquimod
Mesna Protamine Sulfate Verapamil Indinavir
Metformin Pseudoephedrine Vildagliptin Interferon Alfa
Methohexital Pyrimethamine Vinblastine Ipilimumab
Methotrexate Quinapril Vincristine Ketorolac
Methylphenidate Quinestrol Voriconazole Labetalol
Metoclopramide Quinidine Vorinostat Ledipasvir & Sofosbuvir
Metoprolol Quinine Warfarin Lenvatinib
Metronidazole Ramipril Yellow Fever Vaccine Losartan
Miconazole Ranitidine Zalcitabine Methotrexate
Midazolam Riboflavin Zidovudine Mycophenolate
Minocycline Rifampin Ziprasidone Naproxen
Mirtazapine Risperidone Zofenopril Nicorandil
Mitotane Rituximab Anosmia Olanzapine
Moexipril Rofecoxib Amikacin Omacetaxine
Montelukast Ropinirole Aspirin Orlistat
Nabumetone Sacubitril/Valsartan Cocaine Paclitaxel
Nalidixic Acid Saxagliptin Dorzolamide Pantoprazole
Naloxone Secobarbital Doxycycline Paroxetine Hydrochloride
Naproxen Sertraline Enalapril Pemetrexed
Neomycin Sirolimus Interferon Alfa Penicillamine
Nevirapine Sitagliptin Levodopa Piroxicam
Nicardipine Sorafenib Methazolamide Prednisone
Pyrimethamine Co-Trimoxazole Digoxin Phenolphthalein

Rifabutin Cocaine Disulfiram Phenytoin
Rofecoxib Doxycycline Enoxaparin Piroxicam
Sertraline Fluoxetine Entacapone Prednicarbate
Siltuximab Griseofulvin Ephedrine Promethazine
Sirolimus Lansoprazole Erlotinib Propranolol
Sorafenib Linezolid Estrogens Propyphenazone
Sulfadoxine Methyldopa Ethambutol Pyridoxine
Sulfamethoxazole Minocycline Ethchlorvynol Pyrimethamine
Sulfasalazine Nicotine Felbamate Quinethazone
Sulfisoxazole Nortriptyline Fluconazole Reserpine
Tegafur/Gimeracil/Oteracil Olanzapine Fluorouracil Rifampin
Temsirolimus Oxytetracycline Fluoxetine Risperidone
Tocilizumab PEG-Interferon Fluvoxamine Ritonavir
Tosufloxacin Ribavirin Fondaparinux Rituximab
Trametinib Streptomycin Fosphenytoin Rivastigmine
Valsartan Sulfamethoxazole Frovatriptan Rofecoxib
Vedolizumab Tetracycline Furosemide Sertraline
Zalcitabine Thiothixene Ganciclovir Smallpox Vaccine
Baboon syndrome (SDRIFE) Bullous dermatitis Gemcitabine Sparfloxacin
Acetaminophen Acetazolamide Glyburide Streptomycin
Allopurinol Acitretin Gold & Gold Compounds Sulfadoxine
Aminophylline Afatinib Griseofulvin Sulfamethoxazole
Amoxicillin Aldesleukin Heparin Sulfisoxazole
Ampicillin Alemtuzumab Hydralazine Sunitinib
Aspirin Amifostine Hydrochlorothiazide Temazepam
Betamethasone Aminocaproic Acid Hydroxychloroquine Tetracycline
Cefadroxil Aminophylline Ibuprofen Thalidomide
Cefuroxime Aminosalicylate Sodium Ibutilide Thiopental
Celecoxib Amitriptyline Imipramine Tinzaparin
Cephalexin Ampicillin Imiquimod Tolbutamide
Cetuximab Anthrax Vaccine Indomethacin Tranexamic Acid
Cimetidine Argatroban Infliximab Tretinoin
Cisplatin Arsenic Influenza Vaccine Trioxsalen
Clarithromycin Aspirin Insulin Urokinase
Cloxacillin Atropine Sulfate Interferon Alfa Ustekinumab
Clozapine Bleomycin Isoniazid Valproic Acid
Erythromycin Bumetanide Ivermectin Vancomycin
Everolimus Buspirone Ketoprofen Vasopressin
Fluorouracil Busulfan Lamotrigine Vinblastine
Gemcitabine Butabarbital Leflunomide Warfarin
Heparin Butalbital Lindane Zalcitabine
Hydrochlorothiazide Captopril Lisinopril Zidovudine
Hydroxyurea Carbamazepine Lithium Zolpidem
Immune Globulin IV Celecoxib Lomefloxacin DRESS syndrome
Infliximab Cetirizine Mechlorethamine Abacavir
Iomeprol Cevimeline Meloxicam Acenocoumarol
Iopromide Chloral Hydrate Mephenytoin Acetaminophen
Mesalamine Chloramphenicol Meprobamate Allopurinol
Mitomycin Chlorpromazine Methicillin Amikacin
Naproxen Chlorpropamide Methotrexate Amitriptyline
Nystatin Ciprofloxacin Methoxsalen Amoxicillin
Omeprazole Clonazepam Miconazole Ampicillin
Oral Contraceptives Clopidogrel Minoxidil Anakinra
Oxycodone Co-Trimoxazole Mitomycin Aspirin
Penicillin V Cocaine Mometasone Atenolol
Pseudoephedrine Codeine Moxifloxacin Atorvastatin
Ranitidine Colchicine Mycophenolate Azithromycin
Risperidone Cyanocobalamin Nabumetone Benznidazole
Rivastigmine Cyclamate Nalidixic Acid Boceprevir
Roxithromycin Cyclosporine Naproxen Bosentan
Telmisartan Cytarabine Nifedipine Bupropion
Terbinafine Dalteparin Norfloxacin Canakinumab
Black tongue (lingua villosa Dapsone Omeprazole Captopril
nigra) Desoximetasone Oral Contraceptives Carbamazepine
Amoxicillin Dextromethorphan Oxacillin Cefadroxil
Benztropine Diazepam Penicillamine Cefixime
Ceftriaxone Diclofenac Pentamidine Cefotaxime
Chloramphenicol Dicumarol Pentobarbital Ceftriaxone
Clarithromycin Diethylstilbestrol Pentostatin Celecoxib
Clonazepam Diflunisal Phenobarbital Chlorambucil
Cidofovir Rivaroxaban Celecoxib Hyaluronic Acid

Cilostazol Sorafenib Cephalexin Hydrochlorothiazide
Ciprofloxacin Spironolactone Cephalothin Hydroxychloroquine
Clindamycin Streptomycin Chloral Hydrate Hydroxyurea
Clomipramine Strontium Ranelate Chlorambucil Hydroxyzine
Clonazepam Sulfadiazine Chloramphenicol Ibuprofen
Clopidogrel Sulfamethoxazole Chlordiazepoxide Icodextrin
Co-Trimoxazole Sulfasalazine Chloroquine Imatinib
Codeine Teicoplanin Chlorpromazine Imipenem/Cilastatin
Cyclobenzaprine Telaprevir Chlorpropamide Imiquimod
Cycloserine Tenofovir Disoproxil Chlorzoxazone Indapamide
Daclatasvir Tenoxicam Cimetidine Indomethacin
Dapsone Terbinafine Ciprofloxacin Infliximab
Darunavir Teriflunomide Cisplatin Interferon Beta
Dextromethorphan Thiamine Clindamycin Iomeprol
Diclofenac Tocilizumab Clofibrate Ipilimumab
Doxycycline Torsemide Clonazepam Isoniazid
Efalizumab Trimethoprim Clozapine Isotretinoin
Efavirenz Valproic Acid Co-Trimoxazole Ixazomib
Emtricitabine Vancomycin Codeine Ketoprofen
Erlotinib Vemurafenib Collagen (Bovine) Lamotrigine
Esomeprazole Ziprasidone Crizotinib Lansoprazole
Ethambutol Zonisamide Cyclobenzaprine Leflunomide
Febuxostat Erythema multiforme Cyclophosphamide Lenalidomide
Fenofibrate Acamprosate Danazol Levamisole
Fluoxetine Acarbose Dapsone Levetiracetam
Hydroxychloroquine Acebutolol Delavirdine Levofloxacin
Ibuprofen Acetaminophen Desoximetasone Lidocaine
Imatinib Acetazolamide Dexamethasone Lithium
Ipilimumab Adalimumab Diclofenac Loracarbef
Isoniazid Aldesleukin Dicloxacillin Loratadine
Lamotrigine Alectinib Didanosine Lorazepam
Leflunomide Alendronate Diflunisal Maprotiline
Lenalidomide Allopurinol Dihydrocodeine Mechlorethamine
Leucovorin Amifostine Diltiazem Meclofenamate
Levetiracetam Aminosalicylate Sodium Dimenhydrinate Mefenamic Acid
Linezolid Amiodarone Docetaxel Meloxicam
Lithium Amlodipine Dorzolamide Mephenytoin
Metamizole Amoxicillin Doxycycline Meprobamate
Metformin Amphotericin B Durvalumab Metamizole
Methimazole Ampicillin Elotuzumab Methenamine
Minocycline Anthrax Vaccine Enalapril Methicillin
Mitoxantrone Arsenic Enoxacin Methotrexate
Moxifloxacin Aspirin Enoxaparin Methyldopa
Naproxen Atovaquone/Proguanil Erythromycin Minocycline
Nelfinavir Atropine Sulfate Estrogens Minoxidil
Nevirapine Avelumab Ethambutol Misoprostol
Nitrofurantoin Azathioprine Ethosuximide Mitomycin
Olanzapine Aztreonam Etodolac Mitotane
Oxazepam Benznidazole Etoposide Nabumetone
Oxcarbazepine Bezafibrate Etoricoxib Nalidixic Acid
Pandemic Influenza Vaccine Bortezomib Famotidine Naproxen
(H1N1) Bosutinib Fenbufen Neomycin
PEG-Interferon Bumetanide Fenoprofen Nifedipine
Penicillin V Bupropion Flucloxacillin Nilotinib
Perampanel Busulfan Fluconazole Nitrofurantoin
Phenobarbital Butabarbital Fluorouracil Nitroglycerin
Phenylbutazone Butalbital Fluoxetine Nivolumab
Phenytoin Candesartan Flurbiprofen Nystatin
Piperacillin/Tazobactam Carbamazepine Fosphenytoin Ombitasvir/Paritaprevir/
Piroxicam Carisoprodol Furazolidone Ritonavir
Promethazine Cefaclor Furosemide Omeprazole
Propylthiouracil Cefadroxil Gadoversetamide Oral Contraceptives
Pyrazinamide Cefamandole Gemfibrozil Oritavancin
Pyrimethamine Cefixime Glucagon Oxaprozin
Quinine Cefotaxime Glyburide Oxazepam
Raltegravir Cefpodoxime Gold & Gold Compounds Oxybutynin
Ramipril Cefprozil Griseofulvin Paclitaxel
Ribavirin Ceftazidime Hepatitis B Vaccine Pancreatin
Rifampin Ceftriaxone Human Papillomavirus (HPV) Pandemic Influenza Vaccine
Ritonavir Cefuroxime Vaccine (H1N1)
Pantoprazole Vandetanib Ponatinib Bismuth

Paramethadione Vemurafenib Propylthiouracil Bleomycin
Pembrolizumab Verapamil Quinacrine Bortezomib
Pemetrexed Vinblastine Smallpox Vaccine Bosentan
Penicillamine Vitamin A Streptomycin Bosutinib
Pentobarbital Vitamin E Sulfamethoxazole Brompheniramine
Permethrin Voriconazole Sulfasalazine Budesonide
Phenobarbital Zalcitabine Sulfisoxazole Bupropion
Phenolphthalein Zidovudine Terbinafine Buserelin
Phensuximide Erythema nodosum Thalidomide Busulfan
Phenylbutazone Abatacept Ticlopidine Butabarbital
Phenytoin Acetaminophen Tretinoin Butalbital
Piroxicam Acyclovir Trimethoprim Candesartan
Pneumococcal Vaccine Aldesleukin Verapamil Captopril
Pravastatin Amiodarone Zileuton Carbamazepine
Prednicarbate Anastrozole Exanthems Carboplatin
Prednisolone Arsenic Abacavir Carisoprodol
Primidone Aspartame Acamprosate Carmustine
Probenecid Aspirin Acebutolol Carvedilol
Progestins Azathioprine Acenocoumarol Cefaclor
Promethazine Benznidazole Acetaminophen Cefadroxil
Propranolol Busulfan Acetazolamide Cefamandole
Pseudoephedrine Carbamazepine Acetohexamide Cefazolin
Pyrazinamide Carbimazole Acitretin Cefdinir
Pyrimethamine Certolizumab Acyclovir Cefepime
Quetiapine Chlordiazepoxide Aldesleukin Cefoperazone
Quinidine Chlorpropamide Allopurinol Cefotaxime
Quinine Ciprofloxacin Alprazolam Cefoxitin
Ramipril Clomiphene Amantadine Cefpodoxime
Regorafenib Co-Trimoxazole Amcinonide Ceftazidime
Ribavirin Codeine Amikacin Ceftriaxone
Rifampin Colchicine Amiloride Cefuroxime
Ritodrine Dapsone Aminocaproic Acid Celecoxib
Roxatidine Dasatinib Aminoglutethimide Cephalexin
Saquinavir Diclofenac Aminophylline Cephalothin
Scopolamine Disopyramide Aminosalicylate Sodium Cephapirin
Sertraline Estrogens Amiodarone Cephradine
Simvastatin Etanercept Amlodipine Ceritinib
Smallpox Vaccine Fluoxetine Amoxapine Cetirizine
Sorafenib Furosemide Amoxicillin Cetuximab
Spironolactone Glucagon Amphotericin B Cevimeline
Streptomycin Gold & Gold Compounds Ampicillin Chloral Hydrate
Sulfacetamide Granulocyte Colony- Amprenavir Chlorambucil
Sulfadiazine Stimulating Factor (G-CSF) Anastrozole Chloramphenicol
Sulfadoxine Hepatitis B Vaccine Anidulafungin Chlordiazepoxide
Sulfamethoxazole Human Papillomavirus (HPV) Anistreplase Chlormezanone
Sulfasalazine Vaccine Anthrax Vaccine Chloroquine
Sulfisoxazole Hydralazine Aprotinin Chlorothiazide
Sulindac Hydroxychloroquine Arsenic Chlorpromazine
Tamsulosin Ibuprofen Aspartame Chlorpropamide
Telithromycin Imatinib Aspirin Cimetidine
Telmisartan Indomethacin Astemizole Ciprofloxacin
Terbinafine Interferon Alfa Atazanavir Cisplatin
Tetracycline Isotretinoin Atovaquone Citalopram
Tetrazepam Ixazomib Atovaquone/Proguanil Cladribine
Thalidomide Levofloxacin Azacitidine Clarithromycin
Thiabendazole Lidocaine Azathioprine Clemastine
Thiopental Meclofenamate Azelastine Clindamycin
Thioridazine Medroxyprogesterone Azithromycin Clofibrate
Ticlopidine Meprobamate Aztreonam Clomiphene
Tiopronin Metamizole Bacampicillin Clonazepam
Tobramycin Methyldopa Baclofen Clopidogrel
Tocainide Minocycline Benactyzine Clorazepate
Tolbutamide Montelukast Benazepril Cloxacillin
Tolcapone Naproxen Bendamustine Clozapine
Tolmetin Nifedipine Bendroflumethiazide Co-Trimoxazole
Trazodone Nitrofurantoin Benznidazole Cobimetinib
Trihexyphenidyl Omeprazole Betamethasone Codeine
Trimethadione Oral Contraceptives Bevacizumab Colchicine
Valproic Acid Paroxetine Hydrochloride Bexarotene Colestipol
Vancomycin Penicillamine Bicalutamide Cyanocobalamin
Cyclamate Fenofibrate Ketorolac Nifedipine

Cyclophosphamide Fenoprofen Labetalol Nilotinib
Cycloserine Flecainide Lamivudine Nimesulide
Cyclosporine Fluconazole Lamotrigine Nimodipine
Cyclothiazide Flucytosine Lapatinib Nisoldipine
Cyproheptadine Fludarabine Lenalidomide Nitisinone
Cytarabine Fluorouracil Lenvatinib Nitrofurantoin
Dabigatran Fluoxetine Letrozole Nivolumab
Dabrafenib Flurazepam Levamisole Norfloxacin
Dacarbazine Flurbiprofen Levetiracetam Nystatin
Daclizumab Flutamide Levodopa Octreotide
Dalteparin Folic Acid Levofloxacin Ofloxacin
Danazol Foscarnet Lidocaine Olanzapine
Dantrolene Fosfomycin Lincomycin Olmesartan
Dapsone Furazolidone Linezolid Olsalazine
Daunorubicin Furosemide Lisinopril Omeprazole
Deferasirox Gabapentin Lithium Oral Contraceptives
Delavirdine Galantamine Loracarbef Oxacillin
Denosumab Ganciclovir Lovastatin Oxaliplatin
Desipramine Gatifloxacin Maprotiline Oxaprozin
Dexamethasone Gefitinib Mebendazole Oxcarbazepine
Diazepam Gemcitabine Mechlorethamine Paclitaxel
Diclofenac Gemfibrozil Meclofenamate Paliperidone
Dicloxacillin Gemifloxacin Mefenamic Acid Pamidronate
Dicumarol Gentamicin Mefloquine Panobinostat
Dicyclomine Glimepiride Meloxicam Pantoprazole
Diethylpropion Glipizide Melphalan Paromomycin
Diethylstilbestrol Glucagon Memantine Paroxetine Hydrochloride
Diflunisal Glyburide Mephenytoin PEG-Interferon
Digoxin Gold & Gold Compounds Meprobamate Pembrolizumab
Diltiazem Granulocyte Colony- Mercaptopurine Pemoline
Dimenhydrinate Stimulating Factor (G-CSF) Meropenem Penbutolol
Diphenhydramine Grepafloxacin Mesalamine Penicillamine
Dipyridamole Griseofulvin Mesna Penicillin V
Disopyramide Halothane Metamizole Pentagastrin
Disulfiram Heparin Methazolamide Pentamidine
Docetaxel Heroin Methenamine Pentazocine
Docusate Hydralazine Methicillin Pentobarbital
Doxazosin Hydrochlorothiazide Methimazole Pentostatin
Doxepin Hydromorphone Methohexital Perflutren
Doxorubicin Hydroxychloroquine Methotrexate Perphenazine
Doxycycline Hydroxyurea Methoxsalen Phenazopyridine
Dronedarone Hydroxyzine Methsuximide Phenobarbital
Durvalumab Ibrutinib Methyldopa Phenolphthalein
Efavirenz Ibuprofen Methylphenidate Phenylbutazone
Eletriptan Icodextrin Metoclopramide Phenytoin
Elotuzumab Idarubicin Metoprolol Phytonadione
Emtricitabine Imatinib Metronidazole Piperacillin/Tazobactam
Enalapril Imipenem/Cilastatin Mexiletine Piroxicam
Enoxacin Imipramine Miconazole Potassium Iodide
Enoxaparin Imiquimod Minocycline Prazosin
Entecavir Indapamide Minoxidil Prednisolone
Ephedrine Indinavir Misoprostol Primaquine
Epoetin Alfa Indomethacin Mitomycin Primidone
Eprosartan Infliximab Mitotane Pristinamycin
Erlotinib Insulin Moexipril Procainamide
Erythromycin Interferon Alfa Moricizine Procarbazine
Esomeprazole Iobenguane Morphine Prochlorperazine
Estramustine Ipilimumab Nabumetone Promazine
Estrogens Irbesartan Nadolol Promethazine
Etanercept Irinotecan Nafarelin Propafenone
Ethacrynic Acid Isocarboxazid Nafcillin Propofol
Ethambutol Isoniazid Nalidixic Acid Propoxyphene
Ethionamide Isosorbide Dinitrate Naltrexone Propranolol
Ethosuximide Isotretinoin Naproxen Propylthiouracil
Etodolac Isradipine Naratriptan Protamine Sulfate
Etoposide Itraconazole Nefazodone Pseudoephedrine
Etoricoxib Ivermectin Nelfinavir Pyrazinamide
Etravirine Ixazomib Neomycin Pyrimethamine
Everolimus Ketoconazole Nevirapine Quinacrine
Felodipine Ketoprofen Niacin Quinapril
Quinethazone Tolazoline Ciprofloxacin Meclofenamate

Quinidine Tolbutamide Cisplatin Mefenamic Acid
Quinine Tolmetin Clofazimine Mefloquine
Quinupristin/Dalfopristin Topiramate Clofibrate Mephenytoin
Ramipril Tramadol Clonazepam Mephobarbital
Ranitidine Trametinib Co-Trimoxazole Methicillin
Rapacuronium Trazodone Codeine Methsuximide
Regorafenib Triamcinolone Cytarabine Methylphenidate
Repaglinide Trimeprazine Dapsone Mexiletine
Ribavirin Trimethadione Dasatinib Mezlocillin
Rifampin Trimetrexate Daunorubicin Minocycline
Ritodrine Troleandomycin Demeclocycline Mitomycin
Ritonavir Uracil/Tegafur Desipramine Nalidixic Acid
Rituximab Valdecoxib Dexamethasone Nifedipine
Rivastigmine Valproic Acid Diazepam Nilotinib
Rofecoxib Valsartan Diclofenac Nisoldipine
Ropinirole Vancomycin Dicloxacillin Nitisinone
Rucaparib Vardenafil Diethylstilbestrol Nitrofurantoin
Saccharin Vemurafenib Diflunisal Nitroglycerin
Saquinavir Venlafaxine Diltiazem Nivolumab
Scopolamine Verapamil Doxorubicin Omacetaxine
Sertraline Vincristine Efavirenz Ombitasvir/Paritaprevir/
Simvastatin Vitamin A Eletriptan Ritonavir
Smallpox Vaccine Vorapaxar Enalapril Omeprazole
Sorafenib Vorinostat Enoxacin Oxaprozin
Sparfloxacin Warfarin Ephedrine Oxcarbazepine
Spironolactone Zalcitabine Esmolol Oxytetracycline
Streptokinase Zidovudine Esomeprazole Panitumumab
Streptomycin Ziprasidone Estrogens Pantoprazole
Streptozocin Zoledronate Ethambutol Paramethadione
Succimer Zonisamide Ethosuximide Pazopanib
Sucralfate Exfoliative dermatitis Fenoprofen Pembrolizumab
Sulfadiazine Acamprosate Flecainide Pentobarbital
Sulfadoxine Acetaminophen Fluconazole Pentostatin
Sulfamethoxazole Acitretin Flurbiprofen Phenobarbital
Sulfasalazine Afatinib Fluvoxamine Phenolphthalein
Sulfinpyrazone Aldesleukin Fosphenytoin Phenylbutazone
Sulfisoxazole Alitretinoin Furosemide Phenytoin
Sulindac Allopurinol Gefitinib Piroxicam
Tacrine Aminoglutethimide Gemcitabine Procarbazine
Tacrolimus Aminolevulinic Acid Gemfibrozil Propranolol
Tamoxifen Aminophylline Gentamicin Propylthiouracil
Teicoplanin Aminosalicylate Sodium Gold & Gold Compounds Pseudoephedrine
Telaprevir Amiodarone Granulocyte Colony- Pyrimethamine
Telmisartan Amobarbital Stimulating Factor (G-CSF) Quinacrine
Temozolomide Amoxicillin Grepafloxacin Quinapril
Temsirolimus Amphotericin B Griseofulvin Quinidine
Terazosin Ampicillin Hydroxychloroquine Quinine
Terbinafine Arsenic Ibuprofen Raltitrexed
Terfenadine Aspirin Icodextrin Rifampin
Testosterone Avelumab Idelalisib Risperidone
Tetracycline Azathioprine Imatinib Rivastigmine
Tetrazepam Aztreonam Imipramine Romidepsin
Thalidomide Benzyl Alcohol Indomethacin Secobarbital
Thiabendazole Bexarotene Irinotecan Sildenafil
Thiamine Bismuth Isavuconazonium Sulfate Smallpox Vaccine
Thimerosal Bosutinib Isoniazid Sorafenib
Thioguanine Bumetanide Isotretinoin Sparfloxacin
Thiopental Butabarbital Ixabepilone Streptomycin
Thioridazine Butalbital Ixazomib Strontium Ranelate
Thiothixene Capecitabine Ketoconazole Sulfacetamide
Tiagabine Captopril Ketoprofen Sulfadoxine
Ticarcillin Carbamazepine Ketorolac Sulfamethoxazole
Ticlopidine Carvedilol Lansoprazole Sulfasalazine
Tinzaparin Cefoxitin Lapatinib Sulfisoxazole
Tiopronin Cefpodoxime Leflunomide Sulindac
Tipranavir Celecoxib Lenalidomide Sunitinib
Tizanidine Chlorambucil Lidocaine Tacrolimus
Tobramycin Chloroquine Lisinopril Teicoplanin
Tocainide Chlorpropamide Lithium Terfenadine
Tolazamide Cimetidine Lomefloxacin Tetracycline
Thalidomide Clindamycin Meprobamate Sulfamethoxazole

Tiagabine Clioquinol Mesna Sulfasalazine
Ticlopidine Clopidogrel Metamizole Sulfisoxazole
Tizanidine Co-Trimoxazole Metformin Sulindac
Tobramycin Cocaine Methenamine Tadalafil
Tocainide Codeine Methimazole Tartrazine
Trazodone Colchicine Methyldopa Temazepam
Tretinoin Cyproterone Methylphenidate Terbinafine
Trimethadione Dacarbazine Metronidazole Terfenadine
Trimethoprim Danazol Miconazole Tetracycline
Trovafloxacin Dapsone Minocycline Thiabendazole
Vancomycin Demeclocycline Modafinil Thiopental
Venlafaxine Dextromethorphan Nabumetone Ticlopidine
Verapamil Diazepam Naproxen Tinidazole
Vitamin A Diclofenac Neomycin Tolbutamide
Voriconazole Diflunisal Niacin Topiramate
Vorinostat Dimenhydrinate Nifedipine Topotecan
Zalcitabine Diphenhydramine Nimesulide Tosufloxacin
Ziprasidone Disulfiram Nitrofurantoin Tranexamic Acid
Fixed eruption Docetaxel Norfloxacin Triamcinolone
Aceclofenac Doxorubicin Nystatin Trifluoperazine
Acetaminophen Doxycycline Ofloxacin Trimethoprim
Acyclovir Ephedrine Olanzapine Tripelennamine
Adalimumab Erythromycin Olopatadine Triprolidine
Albendazole Esomeprazole Omeprazole Ursodiol
Alendronate Estrogens Ondansetron Valproic Acid
Allopurinol Etanercept Oral Contraceptives Vancomycin
Aminosalicylate Sodium Ethchlorvynol Orphenadrine Voriconazole
Amitriptyline Etodolac Oxazepam Zolmitriptan
Amlexanox Etoricoxib Oxcarbazepine Gingival hyperplasia/
Amodiaquine Finasteride Oxybutynin hypertrophy
Amoxicillin Flavoxate Oxytetracycline Amlodipine
Amphotericin B Flecainide Paclitaxel Basiliximab
Ampicillin Fluconazole Papaverine Carbamazepine
Arsenic Flurbiprofen Paroxetine Hydrochloride Cevimeline
Aspirin Foscarnet PEG-Interferon Clarithromycin
Atenolol Furosemide Pentobarbital Clobazam
Atorvastatin Gabapentin Phenobarbital Co-Trimoxazole
Atropine Sulfate Ganciclovir Phenolphthalein Cycloserine
Azathioprine Glipizide Phenylbutazone Cyclosporine
Bacampicillin Griseofulvin Phenylephrine Diltiazem
BCG Vaccine Guanethidine Phenylpropanolamine Erythromycin
Bisacodyl Heparin Phenytoin Eslicarbazepine
Bismuth Heroin Piperacillin/Tazobactam Everolimus
Bisoprolol Hydralazine Piroxicam Felodipine
Bleomycin Hydrochlorothiazide Procarbazine Fosphenytoin
Bucillamine Hydroxychloroquine Prochlorperazine Isradipine
Butabarbital Hydroxyurea Promethazine Ketoconazole
Butalbital Hydroxyzine Propofol Lamotrigine
Carbamazepine Ibuprofen Propranolol Levetiracetam
Carisoprodol Imipramine Pseudoephedrine Levonorgestrel
Cefaclor Indapamide Pyrazinamide Lithium
Cefazolin Indomethacin Pyridoxine Marihuana
Cefixime Infliximab Pyrimethamine Metoprolol
Ceftazidime Influenza Vaccine Quinacrine Mycophenolate
Ceftriaxone Iohexol Quinidine Nicardipine
Celecoxib Iopromide Quinine Nifedipine
Cephalexin Isotretinoin Ranitidine Nisoldipine
Cetirizine Itraconazole Ribavirin Oral Contraceptives
Chloral Hydrate Ketoconazole Rifampin Palifermin
Chloramphenicol Lamotrigine Rofecoxib Penicillamine
Chlordiazepoxide Leuprolide Ropinirole Phenobarbital
Chlorhexidine Levamisole Roxithromycin Phenytoin
Chlormezanone Levocetirizine Rupatadine Primidone
Chloroquine Lidocaine Saccharin Propranolol
Chlorothiazide Loperamide Saquinavir Sertraline
Chlorpromazine Loratadine Scopolamine Sirolimus
Chlorpropamide Lorazepam Sorafenib Tacrolimus
Cimetidine Meclofenamate Streptomycin Tartrazine
Ciprofloxacin Mefenamic Acid Sulfadiazine Tiagabine
Clarithromycin Meloxicam Sulfadoxine Topiramate
Valproic Acid Temsirolimus Irbesartan Tiopronin

Vemurafenib Trabectedin Isoniazid Tiotropium
Verapamil Trametinib Isotretinoin Tolazamide
Vigabatrin Trastuzumab Ketoconazole Tolbutamide
Voriconazole Uracil/Tegafur Labetalol Torsemide
Zonisamide Valproic Acid Lansoprazole Trichlormethiazide
Hand-foot syndrome Vandetanib Leflunomide Tripelennamine
Afatinib Varenicline Levamisole Triprolidine
Aflibercept Vemurafenib Lisinopril Ursodiol
Axitinib Vincristine Lorazepam Venlafaxine
Bevacizumab Vinorelbine Lovastatin Zidovudine
Bleomycin Vorinostat Mercaptopurine Lupus erythematosus
Bosutinib Lichenoid (lichen planus-like) Mesalamine Acebutolol
Brentuximab Vedotin eruptions Metformin Acetazolamide
Cabazitaxel Acebutolol Methamphetamine Adalimumab
Cabozantinib Acyclovir Methyldopa Albuterol
Capecitabine Adalimumab Methyltestosterone Aldesleukin
Carboplatin Alendronate Metoprolol Allopurinol
Cetuximab Allopurinol Nadolol Aminoglutethimide
Cisplatin Aminosalicylate Sodium Naproxen Aminosalicylate Sodium
Clofarabine Amoxicillin Nebivolol Amiodarone
Co-Trimoxazole Anakinra Nelfinavir Amitriptyline
Cobimetinib Aspirin Nifedipine Anastrozole
Cyclophosphamide Atenolol Nivolumab Anthrax Vaccine
Cytarabine Azathioprine Obinutuzumab Atenolol
Dabrafenib BCG Vaccine Olanzapine Atorvastatin
Dasatinib Captopril Omeprazole Betaxolol
Daunorubicin Carbamazepine Oral Contraceptives Bevacizumab
Docetaxel Carvedilol Orlistat Bortezomib
Doxorubicin Ceftriaxone Pantoprazole Bupropion
Epirubicin Chloral Hydrate PEG-Interferon Butabarbital
Erlotinib Chloroquine Pembrolizumab Butalbital
Etoposide Chlorothiazide Penicillamine Capecitabine
Everolimus Chlorpromazine Phenytoin Captopril
Fluorouracil Chlorpropamide Pindolol Carbamazepine
Gefitinib Cinnarizine Piroxicam Carbimazole
Gemcitabine Clopidogrel Pneumococcal Vaccine Cefepime
Hydroxyurea Co-Trimoxazole Pravastatin Cefuroxime
Ibandronate Colchicine Propranolol Celecoxib
Idarubicin Cycloserine Propylthiouracil Celiprolol
Imatinib Cyclosporine Pyrimethamine Chlorambucil
Infliximab Dactinomycin Quinacrine Chlordiazepoxide
Interferon Alfa Demeclocycline Quinidine Chlorothiazide
Ipilimumab Diazoxide Quinine Chlorpromazine
Irinotecan Diflunisal Ranitidine Chlorpropamide
Ixabepilone Diltiazem Ribavirin Chlorthalidone
Ketoconazole Dorzolamide Rifampin Cilazapril
Lapatinib Enalapril Risperidone Cimetidine
Lenvatinib Etanercept Roxatidine Cinnarizine
Letrozole Ethambutol Salsalate Citalopram
Leucovorin Fluoxymesterone Sildenafil Clobazam
Mercaptopurine Flurbiprofen Simeprevir Clofibrate
Mesalamine Fluvastatin Simvastatin Clonidine
Methotrexate Furosemide Sofosbuvir Clozapine
Mitomycin Glimepiride Solifenacin Co-Trimoxazole
Neratinib Glyburide Sotalol Cyclophosphamide
Nintedanib Gold & Gold Compounds Sparfloxacin Cyclosporine
Olaparib Granulocyte Colony- Spironolactone Cysteamine
Oxaliplatin Stimulating Factor (G-CSF) Streptomycin Danazol
Paclitaxel Griseofulvin Sulfadoxine Dapsone
Palifermin Hepatitis B Vaccine Sulfamethoxazole Dasatinib
Panitumumab Hydrochlorothiazide Sulindac Denosumab
Pazopanib Hydroxychloroquine Temazepam Diethylstilbestrol
PEG-Interferon Hydroxyurea Tenofovir Disoproxil Diltiazem
Phenytoin Ibuprofen Terazosin Disopyramide
Regorafenib Imatinib Terbinafine Docetaxel
Rucaparib Imiquimod Testosterone Domperidone
Sorafenib Immune Globulin IV Tetracycline Doxazosin
Sunitinib Indomethacin Thimerosal Doxorubicin
Tegafur/Gimeracil/Oteracil Infliximab Thioridazine Doxycycline
Temozolomide Interferon Alfa Timolol Efalizumab
Enalapril Pantoprazole Adalimumab Benzthiazide

Esomeprazole PEG-Interferon Allopurinol Bepridil
Estrogens Pembrolizumab Bleomycin Betaxolol
Etanercept Penicillamine Capecitabine Bicalutamide
Ethambutol Pentobarbital Captopril Blinatumomab
Ethionamide Perphenazine Clofazimine Bortezomib
Ethosuximide Phenelzine Dabrafenib Brivaracetam
Fluorouracil Phenobarbital Docetaxel Bromocriptine
Fluoxymesterone Phenolphthalein Doxorubicin Brompheniramine
Fluphenazine Phenylbutazone Estrogens Bupivacaine
Flutamide Phenytoin Etoposide Bupropion
Fluvastatin Pindolol Gold & Gold Compounds Buspirone
Fosphenytoin Piroxicam Hydroxyurea Cabergoline
Furosemide Potassium Iodide Ibuprofen Cabozantinib
Gemcitabine Pravastatin Irinotecan Calcitonin
Gold & Gold Compounds Prazosin Isotretinoin Candesartan
Golimumab Prednicarbate Ketoprofen Capecitabine
Granulocyte Colony- Primidone Methotrexate Captopril
Stimulating Factor (G-CSF) Procainamide Mitoxantrone Carbamazepine
Griseofulvin Promethazine Mycophenolate Carboplatin
Hepatitis B Vaccine Propafenone Nintedanib Carfilzomib
Human Papillomavirus (HPV) Propranolol Nitrofurantoin Carisoprodol
Vaccine Propylthiouracil Oral Contraceptives Carteolol
Hydralazine Psoralens Paclitaxel Carvedilol
Hydrochlorothiazide Quinidine Pemetrexed Caspofungin
Hydroxyurea Quinine Propranolol Ceftazidime
Ibandronate Ranitidine Roxithromycin Ceftibuten
Ibuprofen Reserpine Tasonermin Ceftizoxime
Imipramine Ribavirin Tetracycline Ceftolozane & Tazobactam
Imiquimod Rifabutin Valproic Acid Celecoxib
Immune Globulin IV Rifampin Vemurafenib Cephapirin
Immune Globulin SC Rituximab Paresthesias Ceritinib
Infliximab Sertraline Acamprosate Cetirizine
Interferon Alfa Simvastatin Acetazolamide Cevimeline
Interferon Beta Smallpox Vaccine Acitretin Chloramphenicol
Isoniazid Somatropin Acyclovir Chlorothiazide
Labetalol Spironolactone Adalimumab Chlorpheniramine
Lamotrigine Streptomycin Adenosine Chlorthalidone
Lansoprazole Sulfadiazine Afamelanotide Cidofovir
Leflunomide Sulfamethoxazole Agalsidase Cilostazol
Letrozole Sulfasalazine Alitretinoin Cinacalcet
Leuprolide Sulfisoxazole Allopurinol Cinoxacin
Levodopa Tamoxifen Almotriptan Ciprofloxacin
Lidocaine Terbinafine Alprazolam Cisplatin
Lisinopril Terfenadine Altretamine Citalopram
Lithium Testosterone Amikacin Clemastine
Lovastatin Tetracycline Amiloride Clonazepam
Mephenytoin Thioridazine Amiodarone Clopidogrel
Meprobamate Ticlopidine Amlodipine Clozapine
Mercaptopurine Timolol Amoxapine Coagulation Factor IX
Mesalamine Tiopronin Amphotericin B (Recombinant)
Methimazole Tiotropium Amprenavir Colistin
Methoxsalen Tocainide Anagrelide Copanlisib
Methsuximide Triamterene Apraclonidine Crisaborole
Methyldopa Trichlormethiazide Arbutamine Cyclamate
Methyltestosterone Trientine Arformoterol Cyclobenzaprine
Methysergide Trimethadione Aripiprazole Cyclophosphamide
Metoprolol Trimethoprim Arsenic Cyclosporine
Mexiletine Trioxsalen Artemether/Lumefantrine Cyproheptadine
Minocycline Uracil/Tegafur Articaine Dalfampridine
Minoxidil Valproic Acid Aspirin Daptomycin
Mitotane Vancomycin Astemizole Dasatinib
Nafcillin Verapamil Atorvastatin Delafloxacin
Nalidixic Acid Vitamin E Avanafil Delavirdine
Naproxen Voriconazole Azatadine Demeclocycline
Nifedipine Zafirlukast Azithromycin Denileukin
Nitrofurantoin Zinc Baclofen Desvenlafaxine
Olsalazine Ziprasidone Basiliximab Dexamethasone
Omeprazole Zonisamide Bedaquiline Dexchlorpheniramine
Oral Contraceptives Onycholysis Benazepril Dichlorphenamide
Paclitaxel Acitretin Benznidazole Diclofenac
Diflunisal Gadobutrol Lovastatin Pentamidine

Dihydroergotamine Gadodiamide Lubiprostone Pentostatin
Diltiazem Gadofosveset Maraviroc Pentoxifylline
Dimenhydrinate Gadopentetate MDMA Perampanel
Diphenhydramine Gadoteridol Meclizine Perflutren
Dipyridamole Gadoversetamide Meclofenamate Pergolide
Dirithromycin Gadoxetate Medroxyprogesterone Perindopril
Disopyramide Galantamine Mefloquine Phentermine
Dobutamine Ganciclovir Meloxicam Phenytoin
Docetaxel Gatifloxacin Menadione Pindolol
Dofetilide Gemcitabine Methazolamide Pirbuterol
Dolutegravir Gemfibrozil Methimazole Piroxicam
Donepezil Gentamicin Methyclothiazide Pizotifen
Doxycycline Glatiramer Methyldopa Plasma (Human) Blood
Duloxetine Glipizide Metoclopramide Product
Efavirenz Glucarpidase Metolazone Posaconazole
Eflornithine Glyburide Metronidazole Pramipexole
Eletriptan Grepafloxacin Mexiletine Pravastatin
Eltrombopag Griseofulvin Midodrine Prazosin
Emtricitabine Guanadrel Miglustat Prednicarbate
Enalapril Guanethidine Milnacipran Pregabalin
Enoxacin Guanfacine Miltefosine Prilocaine
Entecavir Halofantrine Minocycline Procarbazine
Enzalutamide Histrelin Mirtazapine Promethazine
Epirubicin Human Papillomavirus Vaccine Mitomycin Propafenone
Epoetin Alfa (Bivalent) Modafinil Propylthiouracil
Epoprostenol Hydrocodone Moricizine Pyridoxine
Eprosartan Hydroflumethiazide Moxifloxacin Quetiapine
Ergotamine Imatinib Nabumetone Quinapril
Ertapenem Imipenem/Cilastatin Nadolol Quinupristin/Dalfopristin
Escitalopram Indapamide Nafarelin Rabeprazole
Esmolol Indinavir Naproxen Ramipril
Esomeprazole Indomethacin Naratriptan Ranolazine
Estazolam Infliximab Nebivolol Rasagiline
Eszopiclone Insulin Nefazodone Rasburicase
Etanercept Interferon Alfa Nelarabine Reboxetine
Etelcalcetide Interferon Beta Nelfinavir Repaglinide
Ethoxzolamide Iodixanol Nesiritide Rifabutin
Etravirine Iohexol Nevirapine Rifampin
Evolocumab Iopromide Niacin Riluzole
Exemestane Ioversol Niacinamide Rimantadine
Ezetimibe Ipilimumab Nicardipine Risedronate
Ezogabine Ipratropium Nifedipine Risperidone
Famciclovir Irbesartan Nilotinib Ritonavir
Famotidine Isavuconazonium Sulfate Nilutamide Rivaroxaban
Febuxostat Isoniazid Nisoldipine Rivastigmine
Felbamate Isradipine Nitrofurantoin Rizatriptan
Felodipine Ixazomib Nivolumab Rofecoxib
Fentanyl Ketoconazole Nizatidine Romiplostim
Ferric Gluconate Ketoprofen Nusinersen Ropinirole
Ferumoxsil Ketorolac Ofloxacin Ropivacaine
Ferumoxytol Labetalol Omacetaxine Rosuvastatin
Fingolimod Lamivudine Omalizumab Rotigotine
Flecainide Lamotrigine Omeprazole Saquinavir
Fluconazole Lansoprazole Ondansetron Sertraline
Flucytosine Laronidase Oseltamivir Sibutramine
Fludarabine Leflunomide Oxaliplatin Sildenafil
Flumazenil Leucovorin Oxilan Siltuximab
Fluorouracil Leuprolide Oxprenolol Sincalide
Fluoxetine Levalbuterol Oxycodone Sipuleucel-T
Flurbiprofen Levamisole Oxytetracycline Sirolimus
Flutamide Levetiracetam Paclitaxel Smallpox Vaccine
Fosamprenavir Levobupivacaine Palifermin Sodium Oxybate
Foscarnet Levofloxacin Pandemic Influenza Vaccine Somatropin
Fosfomycin Levomilnacipran (H1N1) Sotalol
Fosinopril Lidocaine Pantoprazole Sparfloxacin
Fosphenytoin Lisinopril Paricalcitol Stavudine
Frovatriptan Lomefloxacin Paroxetine Hydrochloride Streptomycin
Fulvestrant Loratadine Pegaspargase Succimer
Gabapentin Lorcainide Pegvisomant Sufentanil
Gadobenate Losartan Pembrolizumab Sugammadex
Sulfasalazine Ziconotide Phenobarbital Capecitabine

Sulindac Zidovudine Phenylbutazone Captopril
Sumatriptan Zileuton Phenytoin Carbamazepine
Tacrine Ziprasidone Piroxicam Carisoprodol
Tacrolimus Zoledronate Propranolol Carvedilol
Tadalafil Zolmitriptan Psoralens Cefazolin
Taliglucerase Zolpidem Quinapril Ceftazidime
Tartrazine Zonisamide Ramipril Celecoxib
Tegafur/Gimeracil/Oteracil Zuclopenthixol Rifampin Cetirizine
Telaprevir Pemphigus vulgaris Rituximab Cevimeline
Telbivudine Acetaminophen Secukinumab Chlorambucil
Telithromycin Acetazolamide Spironolactone Chlordiazepoxide
Telmisartan Aldesleukin Timolol Chlorhexidine
Temozolomide Amoxicillin Tiopronin Chloroquine
Terazosin Ampicillin Tocilizumab Chlorothiazide
Terfenadine Aspirin Trandolapril Chlorpheniramine
Teriflunomide Atorvastatin Trioxsalen Chlorpromazine
Teriparatide Avelumab Typhoid Vaccine Chlorpropamide
Tesamorelin Benazepril Peyronie’s disease Chlortetracycline
Testosterone Bucillamine Acebutolol Chlorthalidone
Tetrabenazine Captopril Betaxolol Ciprofloxacin
Tetracycline Carbamazepine Carvedilol Clemastine
Thalidomide Carbimazole Labetalol Clofazimine
Thallium Cefaclor Methotrexate Clofibrate
Thiamine Cefadroxil Metoprolol Clomipramine
Thyrotropin Alfa Cefazolin Nadolol Clopidogrel
Tiagabine Cefixime Papaverine Clorazepate
Tibolone Ceftazidime Pindolol Clozapine
Tiludronate Ceftriaxone Propranolol Co-Trimoxazole
Timolol Cefuroxime Ropinirole Cobimetinib
Tinidazole Cephalexin Timolol Colchicine
Tiotropium Chloroquine Photosensitivity Crizotinib
Tizanidine Cilazapril Acamprosate Cyclamate
Tobramycin Clonidine Aceclofenac Cyproheptadine
Tocainide Cocaine Acetohexamide Dabrafenib
Tofacitinib Cyclophosphamide Acetylcysteine Dacarbazine
Tolcapone Diclofenac Acitretin Danazol
Tolterodine Enalapril Acyclovir Dapsone
Topiramate Epinephrine Aldesleukin Dasatinib
Topotecan Famotidine Alectinib Demeclocycline
Torsemide Fludarabine Allopurinol Desipramine
Trabectedin Fosinopril Almotriptan Desoximetasone
Tramadol Glyburide Alprazolam Dexamethasone
Trandolapril Gold & Gold Compounds Amantadine Dexchlorpheniramine
Trastuzumab Haloperidol Amiloride Diazoxide
Travoprost Hepatitis B Vaccine Aminolevulinic Acid Diclofenac
Trazodone Heroin Aminosalicylate Sodium Diflunisal
Tretinoin Hydroxychloroquine Amiodarone Diltiazem
Triazolam Ibuprofen Amitriptyline Dimenhydrinate
Trihexyphenidyl Imiquimod Amoxapine Diphenhydramine
Trimeprazine Influenza Vaccine Anagrelide Disopyramide
Tripelennamine Ingenol Mebutate Arsenic Docetaxel
Triprolidine Interferon Alfa Astemizole Doxepin
Triptorelin Interferon Beta Atorvastatin Doxycycline
Trovafloxacin Isotretinoin Atropine Sulfate Dronedarone
Unoprostone Ketoprofen Azatadine Duloxetine
Valacyclovir Latanoprost Azathioprine Eculizumab
Valdecoxib Levamisole Azithromycin Efavirenz
Valganciclovir Levodopa Benazepril Enalapril
Valproic Acid Meprobamate Bendroflumethiazide Enoxacin
Valsartan Metamizole Benztropine Epoetin Alfa
Vardenafil Metformin Bezafibrate Erlotinib
Venlafaxine Methoxsalen Bicalutamide Esomeprazole
Verapamil Moexipril Brompheniramine Estrogens
Vernakalant Montelukast Bumetanide Eszopiclone
Vilazodone Mycophenolate Bupropion Ethambutol
Vinblastine Nifedipine Butabarbital Ethionamide
Vincristine Nivolumab Butalbital Etodolac
Vinorelbine Omeprazole Calcipotriol Febuxostat
Voriconazole Pembrolizumab Canagliflozin Felbamate
Zaleplon Penicillamine Candesartan Fenofibrate
Flucytosine Minoxidil Saquinavir Zolpidem

Fluorouracil Mitomycin Scopolamine Pigmentation
Fluoxetine Moexipril Sertraline Acitretin
Flurbiprofen Molindone Sildenafil Adapalene
Flutamide Moxifloxacin Simeprevir Afamelanotide
Fluvoxamine Nabumetone Simvastatin Alitretinoin
Fosinopril Nalidixic Acid Sitagliptin Amantadine
Furazolidone Naproxen Smallpox Vaccine Amifostine
Furosemide Naratriptan Sotalol Aminolevulinic Acid
Ganciclovir Nefazodone Sparfloxacin Amiodarone
Gatifloxacin Nifedipine Streptomycin Amitriptyline
Gemifloxacin Nimesulide Sulfadiazine Amlodipine
Gentamicin Nivolumab Sulfadoxine Amoxicillin
Glimepiride Norfloxacin Sulfamethoxazole Apomorphine
Glipizide Nortriptyline Sulfasalazine Arformoterol
Glyburide Ofloxacin Sulfisoxazole Arsenic
Glycopyrrolate Olanzapine Sulindac Asfotase Alfa
Gold & Gold Compounds Olmesartan Sumatriptan Azacitidine
Grepafloxacin Omalizumab Tacrolimus Azathioprine
Griseofulvin Ombitasvir/Paritaprevir/ Tartrazine Benznidazole
Haloperidol Ritonavir Tegafur/Gimeracil/Oteracil Betaxolol
Heroin Oral Contraceptives Telmisartan Bevacizumab
Hydralazine Oxaprozin Terfenadine Bimatoprost
Hydrochlorothiazide Oxerutins Tetracycline Bismuth
Hydroflumethiazide Oxytetracycline Thimerosal Bleomycin
Hydroxychloroquine Paclitaxel Thioguanine Bortezomib
Hydroxyurea Pantoprazole Thioridazine Bupropion
Hydroxyzine Paroxetine Hydrochloride Thiothixene Busulfan
Hyoscyamine PEG-Interferon Tiagabine Cabozantinib
Ibuprofen Pentobarbital Tiopronin Calcipotriol
Imatinib Pentosan Tiotropium Capecitabine
Imipramine Pentostatin Tocilizumab Captopril
Indapamide Phenelzine Tolazamide Carboplatin
Indomethacin Phenobarbital Tolbutamide Carmustine
Interferon Alfa Phenytoin Tolmetin Ceftriaxone
Interferon Beta Pilocarpine Topiramate Cetirizine
Irbesartan Pimozide Torsemide Cevimeline
Irinotecan Pirfenidone Trametinib Chlorhexidine
Isocarboxazid Piroxicam Tranylcypromine Chloroquine
Isoniazid Polythiazide Trastuzumab Chlorotrianisene
Isotretinoin Porfimer Trazodone Chlorpromazine
Itraconazole Pravastatin Tretinoin Cidofovir
Kanamycin Procainamide Triamterene Ciprofloxacin
Ketoconazole Prochlorperazine Triazolam Cisplatin
Ketoprofen Procyclidine Trichlormethiazide Citalopram
Ketorolac Promazine Trifluoperazine Clobetasol
Lamotrigine Promethazine Trihexyphenidyl Clofazimine
Levofloxacin Propranolol Trimeprazine Clomipramine
Lisinopril Propylthiouracil Trimethadione Clonazepam
Lomefloxacin Protriptyline Trimipramine Clonidine
Loratadine Psoralens Trioxsalen Clozapine
Losartan Pyrazinamide Tripelennamine Co-Trimoxazole
Loxapine Pyridoxine Triprolidine Cobicistat/Elvitegravir/
Maprotiline Pyrimethamine Trovafloxacin Emtricitabine/Tenofovir
Meclizine Quetiapine Uracil/Tegafur Disoproxil
Meclofenamate Quinacrine Valdecoxib Colistin
Meloxicam Quinapril Valproic Acid Collagen (Bovine)
Meprobamate Quinethazone Valsartan Cyclophosphamide
Mercaptopurine Quinidine Vandetanib Dactinomycin
Mesalamine Quinine Vardenafil Dapsone
Mesoridazine Rabeprazole Vemurafenib Dasatinib
Metformin Ramipril Venlafaxine Daunorubicin
Methenamine Ranitidine Verapamil Deferasirox
Methotrexate Regorafenib Verteporfin Degarelix
Methoxsalen Ribavirin Vinblastine Deoxycholic Acid
Methyclothiazide Rifaximin Voriconazole Desipramine
Methyldopa Risperidone Xipamide Dexamethasone
Methylphenidate Ritonavir Zalcitabine Diazepam
Metolazone Ropinirole Zaleplon Dicumarol
Midostaurin Rucaparib Ziprasidone Diethylstilbestrol
Minocycline Saccharin Zolmitriptan Diltiazem
Docetaxel Lidocaine Rifabutin Imatinib

Donepezil Linezolid Rifapentine Isotretinoin
Doxorubicin Lithium Risperidone Ketotifen
Doxycycline Lomefloxacin Ropinirole Lamotrigine
Eletriptan Loxapine Ruxolitinib Lisinopril
Elotuzumab Mechlorethamine Saquinavir Meprobamate
Eltrombopag Medroxyprogesterone Sertraline Metronidazole
Emtricitabine Mephenytoin Sildenafil Mitomycin
Enoxacin Mercaptopurine Siltuximab Naproxen
Epirubicin Mesoridazine Smallpox Vaccine Nimesulide
Erythromycin Methamphetamine Sorafenib Nortriptyline
Esmolol Methotrexate Sparfloxacin Omeprazole
Estradiol Methoxsalen Spironolactone Pneumococcal Vaccine
Estramustine Methyldopa Stanozolol Terbinafine
Estrogens Methysergide Sulfadiazine Tiopronin
Eszopiclone Metoclopramide Sulfasalazine Tripelennamine
Etoposide Minocycline Sunitinib Pruritus
Ezogabine Minoxidil Tacrolimus Abacavir
Fentanyl Mirtazapine Tafluprost Abatacept
Finasteride Mitomycin Tamoxifen Abciximab
Fluconazole Mitotane Tegafur/Gimeracil/Oteracil Acamprosate
Fluorouracil Molindone Telithromycin Acebutolol
Fluoxetine Naratriptan Telmisartan Acetaminophen
Fluphenazine Niacin Terbinafine Acetohexamide
Fluvoxamine Nicotine Tetracycline Acetylcysteine
Foscarnet Nifedipine Thioridazine Acitretin
Ganciclovir Nisoldipine Thiotepa Acyclovir
Gefitinib Nitazoxanide Thiothixene Adalimumab
Glyburide Nitisinone Tiagabine Adapalene
Gold & Gold Compounds Nivolumab Tigecycline Adefovir
Goserelin Olanzapine Tinidazole Ado-Trastuzumab Emtansine
Grepafloxacin Omacetaxine Tolcapone Afatinib
Griseofulvin Omeprazole Topiramate Albendazole
Halobetasol Oral Contraceptives Trastuzumab Albuterol
Haloperidol Orphenadrine Travoprost Alcaftadine
Heroin Oxytetracycline Tretinoin Aldesleukin
Human Papillomavirus (HPV) Paclitaxel Triamcinolone Alefacept
Vaccine Palifermin Trifluoperazine Alemtuzumab
Hyaluronic Acid Panitumumab Trioxsalen Alendronate
Hydrochlorothiazide Pantoprazole Triptorelin Alfentanil
Hydroquinone Paromomycin Unoprostone Alglucerase
Hydroxychloroquine Paroxetine Hydrochloride Uracil/Tegafur Alitretinoin
Hydroxyurea Pazopanib Vandetanib Allopurinol
Idarubicin PEG-Interferon Venlafaxine Almotriptan
Ifosfamide Pemetrexed Verapamil Alogliptin
Imatinib Pentazocine Vinblastine Alpha-Lipoic Acid
Imipramine Pentostatin Vincristine Alprazolam
Imiquimod Perphenazine Vinorelbine Alprostadil
Indapamide Phenazopyridine Vitamin A Altretamine
Indinavir Phenobarbital Voriconazole Alvimopan
Insulin Phenolphthalein Warfarin Amantadine
Interferon Alfa Phenytoin Zidovudine Amcinonide
Ipilimumab Pimozide Zinc Amikacin
Irinotecan Polidocanol Pityriasis rosea-like eruption Amiloride
Isotretinoin Porfimer Acetaminophen Aminoglutethimide
Ixabepilone Prilocaine Acyclovir Aminolevulinic Acid
Ixazomib Procarbazine Allopurinol Aminophylline
Ketoconazole Prochlorperazine Ampicillin Aminosalicylate Sodium
Ketoprofen Promazine Arsenic Amiodarone
Labetalol Propofol Asenapine Amitriptyline
Lamivudine Propranolol Aspirin Amlodipine
Lapatinib Psoralens Atenolol Amodiaquine
Latanoprost Pyridoxine BCG Vaccine Amoxapine
Leflunomide Pyrimethamine Bismuth Amoxicillin
Lenalidomide Quinacrine Captopril Amphotericin B
Leuprolide Quinestrol Clonidine Ampicillin
Levobupivacaine Quinidine Clozapine Anagrelide
Levodopa Quinine Codeine Anastrozole
Levofloxacin Rabeprazole Everolimus Anidulafungin
Levonorgestrel Regorafenib Gold & Gold Compounds Anthrax Vaccine
Levothyroxine Ribavirin Hydrochlorothiazide
Anti-Thymocyte Capecitabine Clonidine Dipyridamole

Immunoglobulin (Rabbit) Captopril Clopidogrel Dirithromycin
Apomorphine Carbamazepine Clotrimazole Disopyramide
Apraclonidine Carbetocin Cloxacillin Dobutamine
Aprepitant Carboplatin Clozapine Docetaxel
Arsenic Carisoprodol Co-Trimoxazole Dolasetron
Artemether/Lumefantrine Carmustine Coagulation Factor IX Dolutegravir
Artesunate Carvedilol (Recombinant) Donepezil
Asfotase Alfa Caspofungin Cobimetinib Doripenem
Asparaginase Cefaclor Codeine Dorzolamide
Aspartame Cefadroxil Colchicine Doxapram
Aspirin Cefamandole Collagen (Bovine) Doxazosin
Astemizole Cefazolin Conivaptan Doxepin
Atazanavir Cefdinir Cromolyn Doxercalciferol
Atenolol Cefditoren Cyanocobalamin Doxorubicin
Atezolizumab Cefepime Cyclamate Doxycycline
Atomoxetine Cefixime Cyclobenzaprine Dronedarone
Atorvastatin Cefmetazole Cyclophosphamide Droperidol
Atovaquone Cefonicid Cyclosporine Duloxetine
Atovaquone/Proguanil Cefoperazone Cytarabine Dupilumab
Atracurium Cefotaxime Dabrafenib Durvalumab
Avelumab Cefotetan Dacarbazine Ecallantide
Axitinib Cefoxitin Daclatasvir Econazole
Azacitidine Cefpodoxime Daclizumab Eculizumab
Azathioprine Cefprozil Dactinomycin Efavirenz
Azithromycin Ceftaroline Fosamil Dalbavancin Eflornithine
Aztreonam Ceftazidime Dalteparin Eletriptan
Bacampicillin Ceftibuten Danaparoid Emtricitabine
Bacitracin Ceftizoxime Danazol Enalapril
Baclofen Ceftobiprole Dapsone Enfuvirtide
Basiliximab Ceftolozane & Tazobactam Daptomycin Enoxacin
Becaplermin Ceftriaxone Darbepoetin Alfa Enoxaparin
Bedaquiline Cefuroxime Darifenacin Enzalutamide
Belinostat Celecoxib Darunavir Epinastine
Benazepril Cephalexin Dasabuvir/Ombitasvir/ Epinephrine
Bendamustine Cephalothin Paritaprevir/Ritonavir Epirubicin
Bendroflumethiazide Cephapirin Dasatinib Epoetin Alfa
Benzalkonium Cephradine Daunorubicin Epoprostenol
Benznidazole Certolizumab Decitabine Eprosartan
Benzyl Alcohol Cetirizine Deferasirox Ergocalciferol
Besifloxacin Cetrorelix Deferoxamine Erlotinib
Betamethasone Cetuximab Defibrotide Ertapenem
Betaxolol Cevimeline Delafloxacin Erythromycin
Bevacizumab Chloral Hydrate Delavirdine Escitalopram
Bexarotene Chlorambucil Demeclocycline Esomeprazole
Bezafibrate Chloramphenicol Denileukin Estazolam
Bicalutamide Chlordiazepoxide Denosumab Estramustine
Bimatoprost Chlorhexidine Deoxycholic Acid Estrogens
Bismuth Chlormezanone Desipramine Eszopiclone
Bleomycin Chloroquine Desonide Etanercept
Boceprevir Chlorothiazide Desoximetasone Etelcalcetide
Bortezomib Chlorpheniramine Dexamethasone Ethambutol
Bosentan Chlorpromazine Dexlansoprazole Etidronate
Bosutinib Chlorpropamide Diatrizoate Etodolac
Botulinum Toxin (A & B) Cholestyramine Diazepam Everolimus
Brentuximab Vedotin Ciclopirox Diclofenac Evolocumab
Brimonidine Cidofovir Dicloxacillin Exemestane
Brinzolamide Cimetidine Dicumarol Exenatide
Brodalumab Cinoxacin Dicyclomine Ezetimibe
Bromfenac Ciprofloxacin Didanosine Factor VIII - von Willebrand
Budesonide Cisplatin Diethylpropion Factor
Bumetanide Citalopram Diethylstilbestrol Famciclovir
Bupivacaine Cladribine Diflunisal Famotidine
Buprenorphine Clarithromycin Difluprednate Febuxostat
Bupropion Clindamycin Digoxin Felbamate
Buspirone Clobetasol Dihydrocodeine Felodipine
Butorphanol Clofarabine Dihydrotachysterol Fenofibrate
Cabergoline Clofazimine Diltiazem Fenoprofen
Calcipotriol Clofibrate Dimethyl Fumarate Fentanyl
Calcium Hydroxylapatite Clomiphene Diphenhydramine Ferric Gluconate
Canagliflozin Clomipramine Diphenoxylate Ferumoxytol
Fidaxomicin Human Papillomavirus (HPV) Ledipasvir & Sofosbuvir Mifepristone

Finafloxacin Vaccine Leflunomide Milnacipran
Finasteride Human Papillomavirus Vaccine Lenalidomide Miltefosine
Fingolimod (Bivalent) Lepirudin Minocycline
Flecainide Hyaluronic Acid Letrozole Minoxidil
Fluconazole Hydralazine Leucovorin Mirabegron
Fludarabine Hydrochlorothiazide Leuprolide Mitomycin
Fluocinonide Hydrocodone Levalbuterol Mitotane
Fluorides Hydrocortisone Levamisole Modafinil
Fluorouracil Hydromorphone Levetiracetam Moexipril
Fluoxetine Hydroquinone Levobunolol Molindone
Fluphenazine Hydroxychloroquine Levobupivacaine Mometasone
Flurbiprofen Hydroxyurea Levofloxacin Moricizine
Fluticasone Propionate Ibandronate Levomilnacipran Morphine
Folic Acid Ibritumomab Levothyroxine Moxifloxacin
Follitropin Alfa/Beta Ibuprofen Lidocaine Mupirocin
Fondaparinux Icatibant Lifitegrast Muromonab-CD3
Formoterol Icodextrin Linagliptin Mycophenolate
Fosamprenavir Idursulfase Lincomycin Nabumetone
Foscarnet Imatinib Lindane Nadolol
Fosfomycin Imidapril Linezolid Nafarelin
Fosinopril Imiglucerase Liraglutide Nalbuphine
Fosphenytoin Imipenem/Cilastatin Lisinopril Nalidixic Acid
Frovatriptan Imipramine Lithium Nalmefene
Fulvestrant Imiquimod Lixisenatide Naloxone
Furazolidone Immune Globulin IV Lodoxamide Naltrexone
Furosemide Immune Globulin SC Lomefloxacin Naproxen
Gabapentin Indapamide Loracarbef Naratriptan
Gadobenate Indinavir Loratadine Natalizumab
Gadobutrol Indomethacin Losartan Necitumumab
Gadodiamide Infliximab Lovastatin Nefazodone
Gadofosveset Ingenol Mebutate Loxapine Nelfinavir
Gadopentetate Insulin Luliconazole Neostigmine
Gadoteridol Insulin Glulisine Lurasidone Nepafenac
Gadoversetamide Interferon Alfa Mafenide Nesiritide
Gadoxetate Iobenguane Maraviroc Nevirapine
Ganciclovir Iodixanol Mebendazole Niacin
Gatifloxacin Iohexol Mechlorethamine Niacinamide
Gefitinib Iomeprol Meclofenamate Nicotine
Gemcitabine Iopromide Medroxyprogesterone Nifedipine
Gemfibrozil Ioversol Mefenamic Acid Nilotinib
Gemifloxacin Ipilimumab Mefloquine Nilutamide
Gemtuzumab Ipratropium Meloxicam Nimesulide
Gentamicin Irbesartan Melphalan Nimodipine
Glatiramer Irinotecan Memantine Nintedanib
Glecaprevir & Pibrentasvir Isavuconazonium Sulfate Meperidine Nisoldipine
Gliclazide Isocarboxazid Mephenytoin Nitazoxanide
Glimepiride Isoniazid Mepivacaine Nitisinone
Glipizide Isosorbide Mononitrate Mepolizumab Nitrofurantoin
Glucosamine Isotretinoin Meprobamate Nitrofurazone
Glyburide Isradipine Meropenem Nitroglycerin
Glycopyrrolate Itraconazole Mesalamine Nivolumab
Gold & Gold Compounds Ivermectin Mesna Nizatidine
Golimumab Ixabepilone Metamizole Norfloxacin
Goserelin Ixazomib Metformin Nystatin
Granulocyte Colony- Ixekizumab Methadone Obeticholic Acid
Stimulating Factor (G-CSF) Japanese Encephalitis Vaccine Methenamine Octreotide
Grepafloxacin Kanamycin Methimazole Ofatumumab
Griseofulvin Ketamine Methotrexate Ofloxacin
Guanabenz Ketoconazole Methoxsalen Olanzapine
Guanfacine Ketoprofen Methyl salicylate Olaparib
Guselkumab Ketorolac Methyldopa Olsalazine
Halcinonide Ketotifen Methylprednisolone Omacetaxine
Halobetasol Labetalol Metolazone Omalizumab
Halofantrine Lacosamide Metoprolol Ombitasvir/Paritaprevir/
Halometasone Lamivudine Metronidazole Ritonavir
Haloperidol Lamotrigine Mexiletine Omeprazole
Heparin Lanreotide Micafungin Ondansetron
Heroin Lansoprazole Miconazole Oral Contraceptives
Histrelin Lapatinib Midazolam Oritavancin
Latanoprost Midodrine Osimertinib
Oxacillin Prochlorperazine Sorafenib Tolazamide

Oxaliplatin Propafenone Sotalol Tolbutamide
Oxaprozin Propofol Sparfloxacin Tolcapone
Oxerutins Propranolol Spectinomycin Tolmetin
Oxilan Propylthiouracil Spinosad Tolterodine
Oxybutynin Protriptyline Spironolactone Tolvaptan
Oxycodone Psoralens Streptokinase Topiramate
Oxymetazoline Pyrazinamide Streptomycin Tositumomab & Iodine131
Oxymorphone Pyrimethamine Streptozocin Tosufloxacin
Oxytetracycline Quazepam Succimer Tramadol
Paclitaxel Quinacrine Succinylcholine Trametinib
Palifermin Quinapril Sucralfate Trandolapril
Paliperidone Quinethazone Sufentanil Tranexamic Acid
Palonosetron Quinidine Sugammadex Trastuzumab
Pancrelipase Quinine Sulfadiazine Travoprost
Panitumumab Quinupristin/Dalfopristin Sulfadoxine Trazodone
Pantoprazole Rabeprazole Sulfamethoxazole Treprostinil
Papaverine Raltegravir Sulfasalazine Tretinoin
Paricalcitol Raltitrexed Sulfisoxazole Triamcinolone
Paromomycin Ramipril Sulindac Triazolam
Paroxetine Hydrochloride Ranibizumab Sumatriptan Trimeprazine
Paroxetine Mesylate Ranitidine Sunitinib Trimethadione
Pasireotide Rasburicase Tacrine Trimethoprim
Pazopanib Regorafenib Tacrolimus Trimetrexate
PEG-Interferon Remifentanil Tadalafil Trioxsalen
Pegaspargase Repaglinide Tafluprost Triprolidine
Pegvisomant Retapamulin Taliglucerase Triptorelin
Pembrolizumab Ribavirin Tamoxifen Troleandomycin
Pemetrexed Ribociclib Tartrazine Trovafloxacin
Penicillamine Rifampin Tazarotene Typhoid Vaccine
Penicillin V Rifapentine Tedizolid Ulipristal
Pentagastrin Rifaximin Tegafur/Gimeracil/Oteracil Unoprostone
Pentamidine Risedronate Tegaserod Ursodiol
Pentazocine Risperidone Teicoplanin Ustekinumab
Pentosan Ritonavir Telaprevir Valdecoxib
Pentostatin Rituximab Telavancin Valganciclovir
Pentoxifylline Rivaroxaban Telbivudine Valproic Acid
Perflutren Rivastigmine Telithromycin Valrubicin
Perindopril Rizatriptan Telmisartan Valsartan
Permethrin Rocuronium Temozolomide Vancomycin
Pertuzumab Rofecoxib Temsirolimus Vandetanib
Phenelzine Romidepsin Terazosin Vardenafil
Phenobarbital Ropinirole Terbinafine Varenicline
Phenolphthalein Ropivacaine Terbutaline Varicella Vaccine
Phenytoin Rosuvastatin Terconazole Vedolizumab
Pimecrolimus Rotigotine Teriflunomide Vemurafenib
Pindolol Rucaparib Tesamorelin Venlafaxine
Pirfenidone Rufinamide Testosterone Verapamil
Piroxicam Saccharin Tetracycline Vernakalant
Plasma (Human) Blood Sacubitril/Valsartan Thalidomide Vincristine
Product Salmeterol Thiabendazole Vitamin A
Pneumococcal Vaccine Saquinavir Thiamine Voriconazole
Podophyllotoxin Sarilumab Thioguanine Vorinostat
Polidocanol Saxagliptin Thiopental Vortioxetine
Pomalidomide Scopolamine Thiotepa Warfarin
Posaconazole Secukinumab Thyrotropin Alfa Zalcitabine
Pralatrexate Sertaconazole Tiagabine Zaleplon
Pramipexole Sertraline Tibolone Ziconotide
Pravastatin Sevelamer Ticlopidine Zidovudine
Praziquantel Sevoflurane Tigecycline Zileuton
Prazosin Sibutramine Tiludronate Zolmitriptan
Prednicarbate Sildenafil Timolol Zolpidem
Prednisolone Siltuximab Tinidazole Zonisamide
Prednisone Simeprevir Tinzaparin Zoster Vaccine
Pregabalin Simvastatin Tiopronin Zuclopenthixol
Prilocaine Sirolimus Tipranavir Pseudolymphoma
Primaquine Smallpox Vaccine Tizanidine Adalimumab
Pristinamycin Sodium Iodide I-131 Tobramycin Aldesleukin
Probenecid Sodium Oxybate Tocainide Allopurinol
Procainamide Sofosbuvir Tocilizumab Alprazolam
Procarbazine Sonidegib Tofacitinib Amitriptyline
Amlodipine Valsartan Chlorthalidone Nivolumab

Aspirin Zoledronate Cimetidine Olanzapine
Atenolol Pseudoporphyria Clarithromycin Ombitasvir/Paritaprevir/
Bromocriptine Acitretin Clonidine Ritonavir
Captopril Amiodarone Clopidogrel Omeprazole
Carbamazepine Ampicillin Co-Trimoxazole Oral Contraceptives
Cefixime Ampicillin/Sulbactam Cyclosporine Oxprenolol
Cefuroxime Aspirin Dabrafenib Paroxetine Hydrochloride
Chlorpromazine Bumetanide Daclizumab PEG-Interferon
Cimetidine Carisoprodol Diclofenac Pembrolizumab
Clarithromycin Cefepime Digoxin Penicillamine
Clonazepam Celecoxib Diltiazem Pentostatin
Clonidine Chlorthalidone Dipyridamole Perindopril
Co-Trimoxazole Ciprofloxacin Docetaxel Phenylbutazone
Cyclosporine Cyclosporine Donepezil Pindolol
Dapsone Diclofenac Doxorubicin Potassium Iodide
Desipramine Diflunisal Doxycycline Prednisolone
Diclofenac Fluorouracil Durvalumab Primaquine
Diflunisal Flutamide Efalizumab Propafenone
Diltiazem Hydrochlorothiazide Eletriptan Propranolol
Doxepin Ibuprofen Enalapril Quinacrine
Estrogens Imatinib Esmolol Quinidine
Etanercept Indomethacin Etanercept Rabeprazole
Ethosuximide Isotretinoin Fexofenadine Ramipril
Ethotoin Ketoprofen Flecainide Ranitidine
Fluorouracil Mefenamic Acid Fluorouracil Ribavirin
Fluoxetine Metformin Fluoxetine Risperidone
Fosinopril Nabumetone Fluoxymesterone Ritonavir
Furosemide Nalidixic Acid Foscarnet Rituximab
Gemcitabine Naproxen Gemfibrozil Rivastigmine
Gemfibrozil Oral Contraceptives Glyburide Rofecoxib
Glatiramer Oxaprozin Gold & Gold Compounds Ropinirole
Gold & Gold Compounds Piroxicam Golimumab Saquinavir
Hepatitis A Vaccine Pyridoxine Granulocyte Colony- Secukinumab
Hepatitis B Vaccine Quinidine Stimulating Factor (G-CSF) Sertraline
Hydrochlorothiazide Rofecoxib Human Papillomavirus (HPV) Siltuximab
Ibuprofen Tetracycline Vaccine Sitagliptin
Imatinib Torsemide Hydroxychloroquine Sorafenib
Indomethacin Triamterene Hydroxyurea Sotalol
Infliximab Voriconazole Ibuprofen Sulfamethoxazole
Interferon Alfa Psoriasis Imatinib Sulfasalazine
Ketoprofen Abatacept Imiquimod Sulfisoxazole
Lamotrigine Acebutolol Indomethacin Tacrine
Leucovorin Aceclofenac Infliximab Tazarotene
Lisinopril Acetazolamide Interferon Alfa Telmisartan
Lithium Acitretin Interferon Beta Terbinafine
Lorazepam Adalimumab Ketoprofen Terfenadine
Losartan Aldesleukin Labetalol Teriflunomide
Lovastatin Aminoglutethimide Lapatinib Testosterone
Methotrexate Amiodarone Letrozole Tetracycline
Methylphenidate Amoxicillin Levamisole Thalidomide
Metoprolol Ampicillin Levetiracetam Thioguanine
Mexiletine Anakinra Levobetaxolol Tiagabine
Nabumetone Apremilast Lisinopril Timolol
Naproxen Arsenic Lithium Tocilizumab
Nitrofurantoin Aspirin Losartan Tofacitinib
Nizatidine Atenolol MDMA Trazodone
Oxaliplatin Avelumab Meclofenamate Urapidil
Oxaprozin BCG Vaccine Mefloquine Ustekinumab
Perphenazine Betamethasone Meloxicam Valdecoxib
Phenobarbital Bisoprolol Mesalamine Vedolizumab
Phenytoin Bupropion Methicillin Venlafaxine
Procainamide Calcipotriol Methotrexate Voriconazole
Ranitidine Candesartan Methyltestosterone Purpura
Sulfamethoxazole Captopril Metipranolol Acenocoumarol
Sulfasalazine Carbamazepine Metoprolol Acetaminophen
Sulindac Carvedilol Modafinil Acetazolamide
Tamoxifen Certolizumab Morphine Acitretin
Terfenadine Cetuximab Mycophenolate Adalimumab
Thioridazine Chlorambucil Nadolol Aldesleukin
Valproic Acid Chloroquine Nilotinib Alemtuzumab
Allopurinol Deferiprone Ibritumomab Nitroglycerin

Alteplase Delavirdine Ibuprofen Octreotide
Aminocaproic Acid Desipramine Imatinib Olanzapine
Aminoglutethimide Diazepam Imipramine Omacetaxine
Aminolevulinic Acid Diclofenac Indomethacin Oral Contraceptives
Aminosalicylate Sodium Dicumarol Infliximab Oxaliplatin
Amiodarone Diethylpropion Influenza Vaccine Oxcarbazepine
Amitriptyline Diethylstilbestrol Insulin Oxytetracycline
Amlodipine Digoxin Interferon Alfa Pandemic Influenza Vaccine
Amphotericin B Diltiazem Interferon Beta (H1N1)
Ampicillin Diphenhydramine Iohexol Paroxetine Hydrochloride
Anastrozole Dipyridamole Ipodate Pegaspargase
Anti-Thymocyte Globulin Disopyramide Isoniazid Penicillamine
(Equine) Disulfiram Isotretinoin Pentagastrin
Arsenic Donepezil Itraconazole Pentobarbital
Artemether/Lumefantrine Doxazosin Ketoconazole Pentosan
Aspartame Doxepin Ketoprofen Pentostatin
Aspirin Doxorubicin Ketorolac Perindopril
Azacitidine Doxycycline Labetalol Phenobarbital
Aztreonam Drotrecogin Alfa Lamotrigine Phensuximide
Bendamustine Duloxetine Leflunomide Phenytoin
Beta-Carotene Enalapril Lenalidomide Pirbuterol
Betaxolol Enoxacin Leuprolide Piroxicam
Bevacizumab Enoxaparin Levamisole Plicamycin
Bortezomib Entacapone Levobupivacaine Pravastatin
Botulinum Toxin (A & B) Ephedrine Levodopa Prednisone
Buspirone Eprosartan Levofloxacin Prilocaine
Busulfan Erlotinib Lidocaine Procainamide
Butabarbital Escitalopram Lincomycin Prochlorperazine
Butalbital Estazolam Lindane Promethazine
Capecitabine Estramustine Linezolid Propafenone
Captopril Estrogens Lisinopril Propranolol
Carbamazepine Etanercept Lithium Propylthiouracil
Carbenicillin Ethacrynic Acid Lomefloxacin Pyrimethamine
Carteolol Ethambutol Loratadine Quinidine
Carvedilol Ethchlorvynol Losartan Quinine
Cefaclor Ethionamide Lovastatin Ramipril
Cefoxitin Ethosuximide Maprotiline Ranitidine
Celecoxib Ethotoin Measles, Mumps & Rubella Rapacuronium
Cephalothin Famotidine (MMR) Virus Vaccine Rifampin
Cetirizine Febuxostat Mecasermin Rifapentine
Chloral Hydrate Felodipine Mechlorethamine Risperidone
Chlorambucil Fenoprofen Meclofenamate Rituximab
Chloramphenicol Fentanyl Medroxyprogesterone Rivastigmine
Chlordiazepoxide Flucloxacillin Mefloquine Ropinirole
Chlorothiazide Fluconazole Meloxicam Rosuvastatin
Chlorpromazine Fluoxetine Meningococcal Groups C & Y Rotigotine
Chlorpropamide Fluvoxamine & Haemophilus B Tetanus Ruxolitinib
Chlorthalidone Fondaparinux Toxoid Conjugate Vaccine Sertraline
Cilostazol Frovatriptan Mephenytoin Sildenafil
Cinacalcet Furosemide Meprobamate Simvastatin
Ciprofloxacin Gabapentin Metformin Sirolimus
Citalopram Galantamine Methimazole Smallpox Vaccine
Cladribine Gefitinib Methoxsalen Streptokinase
Clarithromycin Gentamicin Methyldopa Streptomycin
Clidinium Glatiramer Methylphenidate Sulfadoxine
Clofibrate Glipizide Metoclopramide Sulfamethoxazole
Clomiphene Glyburide Metolazone Sulfasalazine
Clomipramine Gold & Gold Compounds Miconazole Sulfisoxazole
Clonazepam Griseofulvin Minocycline Sulindac
Clopidogrel Guanfacine Mirabegron Tacrine
Clozapine Heparin Mitomycin Tacrolimus
Co-Trimoxazole Hepatitis B Vaccine Mitoxantrone Tadalafil
Cocaine Heroin Montelukast Tamoxifen
Codeine Histrelin Nalidixic Acid Tartrazine
Cycloserine Hyaluronic Acid Naproxen Teicoplanin
Cyclosporine Hydralazine Naratriptan Tetracycline
Cytarabine Hydrochlorothiazide Natalizumab Thalidomide
Dabigatran Hydrocortisone Nifedipine Thiamine
Danazol Hydroxyurea Nimesulide Thiopental
Dapsone Hydroxyzine Nitrofurantoin Ticlopidine
Tinzaparin Sulindac Diazepam Methamphetamine

Tizanidine Sumatriptan Diclofenac Methohexital
Tolbutamide Tegafur/Gimeracil/Oteracil Didanosine Metoprolol
Tolmetin Tegaserod Digoxin Minocycline
Topiramate Telmisartan Diltiazem Mirtazapine
Topotecan Thiothixene Diphenhydramine Mizoribine
Torsemide Timolol Distigmine Molindone
Tosufloxacin Uracil/Tegafur Dolutegravir Morphine
Trichlormethiazide Vinblastine Domperidone Moxifloxacin
Trimethadione Vincristine Doxepin Naltrexone
Tripelennamine Zolmitriptan Droperidol Naproxen
Valacyclovir Rhabdomyolysis Enflurane Nefazodone
Valproic Acid Abacavir Enoxacin Nelarabine
Vancomycin Abiraterone Epinephrine Nelfinavir
Varicella Vaccine Acetaminophen Erlotinib Nitrazepam
Vasopressin Aldesleukin Erythromycin Nivolumab
Verapamil Allopurinol Esomeprazole Norfloxacin
Voriconazole Alprazolam Fenbufen Ofloxacin
Warfarin Aminocaproic Acid Fenofibrate Olanzapine
Zolpidem Aminophylline Fluconazole Omeprazole
Zonisamide Amiodarone Fluorouracil Paclitaxel
Raynaud’s phenomenon Amisulpride Fluoxetine Palbociclib
Acebutolol Amitriptyline Fluphenazine Paliperidone
Amphotericin B Amlodipine Fluprednisolone Pancuronium
Aripiprazole Amobarbital Fluvastatin Pantoprazole
Arsenic Amoxicillin Fusidic Acid PEG-Interferon
Atenolol Amphotericin B Gabapentin Pembrolizumab
Bisoprolol Aprobarbital Gatifloxacin Pemetrexed
Bleomycin Aspirin Gemcitabine Pemoline
Bromocriptine Atorvastatin Gemfibrozil Pentamidine
Carboplatin Atropine Sulfate Haloperidol Pentobarbital
Carteolol Azacitidine Halothane Perphenazine
Cisplatin Azathioprine Heroin Phendimetrazine
Clonidine Azithromycin Hydroxychloroquine Phenelzine
Cocaine Baclofen Ibuprofen Phenobarbital
Cyclosporine Benztropine Imatinib Phenylpropanolamine
Dextroamphetamine Bezafibrate Infliximab Phenytoin
Dopamine Buprenorphine Influenza Vaccine Pioglitazone
Doxorubicin Bupropion Interferon Alfa Pravastatin
Estrogens Butabarbital Interferon Beta Pregabalin
Ethosuximide Butalbital Ipilimumab Primidone
Fluoxetine Carbamazepine Isoflurane Propofol
Gemcitabine Chlorpromazine Isoniazid Protamine Sulfate
Gemfibrozil Cholestyramine Isotretinoin Protriptyline
Hepatitis B Vaccine Ciprofibrate Itraconazole Pyrazinamide
Human Papillomavirus (HPV) Ciprofloxacin Ketoconazole Quetiapine
Vaccine Cisplatin Labetalol Quinacrine
Hydroxyurea Citalopram Lamivudine Quinine
Iloprost Clarithromycin Lamotrigine Rabeprazole
Interferon Alfa Clofibrate Leflunomide Raltegravir
Interferon Beta Clopidogrel Lenalidomide Ranolazine
Isotretinoin Clozapine Leuprolide Ribavirin
Labetalol Co-Trimoxazole Levetiracetam Risperidone
Lamotrigine Cobicistat/Elvitegravir/ Levodopa Ritodrine
Leflunomide Emtricitabine/Tenofovir Levofloxacin Ritonavir
Methotrexate Disoproxil Levomepromazine Rosuvastatin
Methylphenidate Cocaine Lindane Secobarbital
Metoprolol Colchicine Linezolid Sertraline
Minocycline Colistin Lithium Sevoflurane
Nadolol Cyclosporine Lorazepam Sildenafil
Octreotide Cytarabine Lovastatin Simeprevir
Phentermine Dacarbazine Loxapine Simvastatin
Pindolol Danazol Lurasidone Sirolimus
Propofol Daptomycin Maraviroc Sitagliptin
Propranolol Dasatinib MDMA Sonidegib
Quinine Deferasirox Meloxicam Sotalol
Ribavirin Delavirdine Melphalan Stanozolol
Rofecoxib Desipramine Mephobarbital Streptokinase
Sotalol Dexketoprofen Meprobamate Streptomycin
Spironolactone Dextroamphetamine Metformin Succinylcholine
Sulfasalazine Diatrizoate Methadone Sulfamethoxazole
Sulfasalazine Captopril Felbamate Minoxidil

Sulpiride Carbamazepine Fenbufen Mizoribine
Sunitinib Carvedilol Fenoprofen Modafinil
Tacrolimus Cefaclor Fexofenadine Nabumetone
Tasonermin Cefadroxil Flucloxacillin Naproxen
Tenecteplase Cefamandole Fluconazole Nevirapine
Tenofovir Disoproxil Cefazolin Fluoxetine Nifedipine
Terbinafine Cefdinir Flurbiprofen Nimesulide
Terbutaline Cefepime Furosemide Nitrofurantoin
Teriflunomide Cefixime Gabapentin Nivolumab
Terlipressin Cefmetazole Galantamine Norfloxacin
Thiopental Cefonicid Gemcitabine Nystatin
Ticagrelor Cefoperazone Glipizide Ofloxacin
Tolcapone Cefotaxime Griseofulvin Omeprazole
Tolvaptan Cefotetan Heparin Oral Contraceptives
Trabectedin Cefoxitin Human Papillomavirus (HPV) Oxacillin
Trametinib Cefpodoxime Vaccine Oxaprozin
Trandolapril Cefprozil Hydrochlorothiazide Oxcarbazepine
Tranylcypromine Ceftazidime Hydroxychloroquine Paclitaxel
Trifluoperazine Ceftibuten Ibuprofen Pantoprazole
Trimethoprim Ceftizoxime Imatinib PEG-Interferon
Trospium Ceftriaxone Immune Globulin IV Pembrolizumab
Valproic Acid Cefuroxime Indapamide Pentamidine
Vasopressin Celecoxib Indinavir Pentobarbital
Venlafaxine Cephalexin Indomethacin Peplomycin
Verapamil Cephalothin Infliximab Phenobarbital
Vinblastine Cephapirin Iohexol Phenolphthalein
Warfarin Cephradine Ipilimumab Phenylbutazone
Ziconotide Cetuximab Isoniazid Phenytoin
Ziprasidone Chloramphenicol Itraconazole Piroxicam
Stevens-Johnson syndrome Chlordiazepoxide Ivermectin Prednisolone
Abacavir Chlormezanone Ixazomib Pristinamycin
Aceclofenac Chloroquine Ketoprofen Promethazine
Acetaminophen Chlorpropamide Ketorolac Propranolol
Acetazolamide Cimetidine Lacosamide Pyrimethamine
Acyclovir Ciprofloxacin Lamivudine Quinine
Adalimumab Cisplatin Lamotrigine Raltegravir
Adefovir Clarithromycin Lansoprazole Ramipril
Afatinib Clindamycin Leflunomide Ranitidine
Albendazole Clobazam Lenalidomide Regorafenib
Albuterol Clofibrate Levamisole Ribavirin
Aldesleukin Clopidogrel Levetiracetam Rifampin
Allopurinol Cloxacillin Levofloxacin Risedronate
Alogliptin Clozapine Lidocaine Rituximab
Amifostine Co-Trimoxazole Lincomycin Rofecoxib
Aminophylline Cocaine Lomefloxacin Secobarbital
Amiodarone Cyclophosphamide Loracarbef Sertraline
Amlodipine Cycloserine Lorazepam Sibutramine
Amobarbital Dapsone Lovastatin Sitagliptin
Amoxicillin Darunavir Lymecycline Smallpox Vaccine
Ampicillin Delavirdine Maprotiline Sorafenib
Amprenavir Dexamethasone Mebendazole Stavudine
Anthrax Vaccine Diclofenac Mechlorethamine Streptomycin
Aripiprazole Dicloxacillin Meclofenamate Strontium Ranelate
Arsenic Didanosine Mefenamic Acid Sulfacetamide
Aspirin Diflunisal Mefloquine Sulfadiazine
Astemizole Diltiazem Meloxicam Sulfadoxine
Atovaquone Dimenhydrinate Mephenytoin Sulfamethoxazole
Atovaquone/Proguanil Dipyridamole Mephobarbital Sulfasalazine
Atropine Sulfate Docetaxel Meprobamate Sulfisoxazole
Azathioprine Doxycycline Metamizole Sulindac
Azithromycin Duloxetine Methazolamide Tamoxifen
Bendamustine Efavirenz Methimazole Tegafur/Gimeracil/Oteracil
Benznidazole Enalapril Methotrexate Teicoplanin
Bezafibrate Enoxacin Methsuximide Telaprevir
Bleomycin Erythromycin Methyldopa Temozolomide
Bromfenac Ethambutol Methylprednisolone Tenofovir Disoproxil
Bupropion Ethosuximide Metronidazole Terbinafine
Butabarbital Etodolac Mexiletine Teriflunomide
Butalbital Etoposide Miltefosine Tetracycline
Capecitabine Etoricoxib Minocycline Tetrazepam
Thalidomide Degarelix Rivastigmine Caspofungin

Thiabendazole Delafloxacin Ropivacaine Cefaclor
Thiopental Desvenlafaxine Rotigotine Cefamandole
Ticlopidine Dexamethasone Ruxolitinib Cefazolin
Tigecycline Dexlansoprazole Salsalate Cefixime
Tiludronate Doxepin Sertraline Cefotaxime
Tocainide Doxycycline Sildenafil Cefoxitin
Tolmetin Dronabinol Sirolimus Ceftazidime
Torsemide Duloxetine Sodium Oxybate Ceftriaxone
Trimethadione Eletriptan Sorafenib Cefuroxime
Trimethoprim Elotuzumab Sumatriptan Celecoxib
Trovafloxacin Eprosartan Tacrolimus Cephalexin
Valdecoxib Erlotinib Tadalafil Cephalothin
Valproic Acid Erythromycin Teicoplanin Cephradine
Vancomycin Escitalopram Tetracycline Cetuximab
Vandetanib Eslicarbazepine Tiagabine Chlorambucil
Varicella Vaccine Esomeprazole Tobramycin Chloramphenicol
Vemurafenib Eszopiclone Tramadol Chlormezanone
Venlafaxine Etanercept Triptorelin Chloroquine
Verapamil Ethambutol Valdecoxib Chlorpromazine
Vitamin A Etoposide Valproic Acid Chlorpropamide
Voriconazole Febuxostat Vancomycin Chlorthalidone
Zidovudine Frovatriptan Vardenafil Cilostazol
Zoledronate Gadodiamide Venlafaxine Cimetidine
Zonisamide Gadoteridol Vigabatrin Ciprofloxacin
Tinnitus Gadoversetamide Vinblastine Cisplatin
Acamprosate Gentamicin Vincristine Cladribine
Acetaminophen Glatiramer Voriconazole Clarithromycin
Acetazolamide Halofantrine Zaleplon Clindamycin
Acitretin Hepatitis B Vaccine Ziconotide Clobazam
Adalimumab Hydroxychloroquine Ziprasidone Co-Trimoxazole
Almotriptan Ibuprofen Zolpidem Codeine
Amikacin Imipramine Zonisamide Colchicine
Amitriptyline Indomethacin Toxic epidermal necrolysis Cyclophosphamide
Anagrelide Interferon Alfa (TEN) Cyclosporine
Aprepitant Isavuconazonium Sulfate Abacavir Cytarabine
Arsenic Isoniazid Aceclofenac Dapsone
Artemether/Lumefantrine Kanamycin Acetaminophen Darunavir
Artesunate Ketorolac Acetazolamide Deflazacort
Aspirin Lapatinib Adefovir Demeclocycline
Atorvastatin Lenalidomide Aldesleukin Denileukin
Azithromycin Levobetaxolol Alfuzosin Dexamethasone
Bedaquiline Levofloxacin Allopurinol Dextroamphetamine
Betaxolol Lidocaine Alprostadil Diatrizoate
Bismuth Mefloquine Amifostine Diclofenac
Bleomycin Meloxicam Aminosalicylate Sodium Diflunisal
Bortezomib Mesalamine Amiodarone Diltiazem
Botulinum Toxin (A & B) Methyl salicylate Amlodipine Diphenhydramine
Bupropion Metronidazole Amobarbital Dipyridamole
Carbimazole Minocycline Amoxapine Disulfiram
Carboplatin Moexipril Amoxicillin Docetaxel
Carvedilol Moxifloxacin Ampicillin Dorzolamide
Cefpodoxime Muromonab-CD3 Anthrax Vaccine Doxycycline
Chlorambucil Nabumetone Arsenic Dronedarone
Chloramphenicol Nadolol Asparaginase Efavirenz
Chloroquine Naproxen Aspirin Enalapril
Chlorpromazine Nitroprusside Atorvastatin Enoxacin
Cilostazol Omacetaxine Atovaquone Ephedrine
Ciprofloxacin Pamidronate Azathioprine Erythromycin
Cisplatin Paromomycin Aztreonam Eslicarbazepine
Citalopram PEG-Interferon BCG Vaccine Ethambutol
Clarithromycin Perflutren Bendamustine Etidronate
Clindamycin Phenelzine Benznidazole Etodolac
Clomipramine Piroxicam Bezafibrate Etoricoxib
Colistin Propylthiouracil Bucillamine Famotidine
Cyclobenzaprine Quinine Busulfan Felbamate
Cycloserine Rabeprazole Butabarbital Fenbufen
Cyclosporine Ranitidine Butalbital Fenofibrate
Dasatinib Ranolazine Captopril Fenoprofen
Daunorubicin Ribavirin Carbamazepine Fexofenadine
Deferoxamine Rifaximin Carbenicillin Flucloxacillin
Fluconazole Nalidixic Acid Thalidomide Asparaginase Erwinia

Fludarabine Naproxen Thiabendazole chrysanthemi
Fluoxetine Neomycin Thiopental Aspartame
Fluphenazine Nevirapine Thioridazine Aspirin
Flurazepam Nifedipine Timolol Astemizole
Flurbiprofen Nitrofurantoin Tolbutamide Atenolol
Fluvoxamine Nivolumab Tolmetin Atorvastatin
Foscarnet Norfloxacin Trimethoprim Atovaquone/Proguanil
Furosemide Ofloxacin Trovafloxacin Atracurium
Gefitinib Omeprazole Valdecoxib Atropine Sulfate
Gemcitabine Ondansetron Valproic Acid Azacitidine
Gemeprost Oseltamivir Vancomycin Azathioprine
Gentamicin Oxaprozin Vemurafenib Azithromycin
Gold & Gold Compounds Oxazepam Vinorelbine Aztreonam
Grepafloxacin Oxcarbazepine Voriconazole Bacitracin
Griseofulvin Pantoprazole Warfarin BCG Vaccine
Heparin Papaverine Zidovudine Benazepril
Heroin PEG-Interferon Zonisamide Benznidazole
Hydralazine Pemetrexed Urticaria Bepotastine
Hydrochlorothiazide Penicillamine Abatacept Betamethasone
Hydroxychloroquine Penicillin V Acamprosate Bezafibrate
Ibandronate Pentamidine Acarbose Bismuth
Ibuprofen Pentazocine Acebutolol Bosutinib
Imatinib Pentobarbital Aceclofenac Brinzolamide
Imipenem/Cilastatin Phenobarbital Acetaminophen Bumetanide
Immune Globulin IV Phenolphthalein Acetohexamide Bupropion
Indapamide Phenylbutazone Acetylcysteine Buspirone
Indomethacin Phenytoin Acyclovir Busulfan
Infliximab Piroxicam Adalimumab Butorphanol
Iohexol Plicamycin Albendazole Calcipotriol
Ipilimumab Prednisolone Albiglutide Calcitonin
Isoniazid Primidone Albuterol Canagliflozin
Isotretinoin Pristinamycin Alclometasone Captopril
Ivermectin Procarbazine Aldesleukin Carbamazepine
Ketoprofen Prochlorperazine Alefacept Carbenicillin
Ketorolac Promethazine Alemtuzumab Carboplatin
Lacosamide Propranolol Alendronate Carisoprodol
Lamivudine Propylthiouracil Alfentanil Caspofungin
Lamotrigine Pyridoxine Alglucerase Cefaclor
Lansoprazole Pyrimethamine Alglucosidase Alfa Cefadroxil
Latanoprost Quinidine Alirocumab Cefamandole
Leflunomide Quinine Allopurinol Cefazolin
Lenalidomide Ranitidine Alpha-Lipoic Acid Cefdinir
Letrozole Regorafenib Alprazolam Cefditoren
Levetiracetam Reserpine Alprostadil Cefepime
Levofloxacin Ribavirin Alteplase Cefixime
Lincomycin Rifampin Amcinonide Cefmetazole
Lomefloxacin Rifaximin Aminolevulinic Acid Cefonicid
Lomustine Ritodrine Aminophylline Cefoperazone
Meclofenamate Rituximab Aminosalicylate Sodium Cefotaxime
Mefenamic Acid Rofecoxib Amiodarone Cefotetan
Mefloquine Smallpox Vaccine Amlodipine Cefpodoxime
Meloxicam Stavudine Amobarbital Cefprozil
Meperidine Streptomycin Amodiaquine Ceftaroline Fosamil
Mephenytoin Streptozocin Amoxapine Ceftazidime
Meprobamate Strontium Ranelate Amoxicillin Ceftibuten
Mercaptopurine Sulfacetamide Amphotericin B Ceftizoxime
Meropenem Sulfadiazine Ampicillin Ceftolozane & Tazobactam
Mesna Sulfadoxine Anagrelide Ceftriaxone
Metamizole Sulfamethoxazole Anakinra Cefuroxime
Methamphetamine Sulfasalazine Anidulafungin Celecoxib
Methazolamide Sulfisoxazole Anistreplase Cephalexin
Methimazole Sulindac Anthrax Vaccine Cephalothin
Methotrexate Tegafur/Gimeracil/Oteracil Anti-Thymocyte Globulin Cephapirin
Metolazone Telaprevir (Equine) Cephradine
Metronidazole Temozolomide Aprepitant Certolizumab
Minocycline Terbinafine Arsenic Cetirizine
Minoxidil Terconazole Artemether/Lumefantrine Chloral Hydrate
Moxifloxacin Teriflunomide Artesunate Chlorambucil
Mupirocin Tetracycline Asfotase Alfa Chloramphenicol
Nabumetone Tetrazepam Asparaginase Chlordiazepoxide
Chlorhexidine Diltiazem Glatiramer Leucovorin

Chloroquine Dimenhydrinate Glimepiride Leuprolide
Chlorothiazide Dimethyl Fumarate Glipizide Levamisole
Chlorpromazine Dinutuximab Glucagon Levetiracetam
Chlorpropamide Diphenoxylate Glyburide Levocetirizine
Chlorthalidone Dipyridamole Gold & Gold Compounds Levofloxacin
Chlorzoxazone Dirithromycin Golimumab Levomilnacipran
Cidofovir Disulfiram Granulocyte Colony- Levonorgestrel
Cilostazol Docetaxel Stimulating Factor (G-CSF) Levothyroxine
Cimetidine Donepezil Grepafloxacin Lidocaine
Cinoxacin Doxacurium Griseofulvin Linaclotide
Ciprofloxacin Doxazosin Halothane Linagliptin
Cisplatin Doxorubicin Heparin Lincomycin
Clarithromycin Doxycycline Hepatitis B Vaccine Lindane
Clemastine Efalizumab Heroin Linezolid
Clindamycin Efavirenz Histrelin Liothyronine
Clioquinol Eletriptan Human Papillomavirus Vaccine Liraglutide
Clofibrate Emtricitabine (Bivalent) Lisinopril
Clomiphene Enalapril Hydrochlorothiazide Lithium
Clomipramine Enfuvirtide Hydrocodone Lixisenatide
Clonidine Enoxacin Hydrocortisone Lomefloxacin
Clopidogrel Enoxaparin Hydromorphone Loracarbef
Clorazepate Ephedrine Hydroxychloroquine Loratadine
Cloxacillin Ertapenem Hydroxyzine Losartan
Clozapine Erythromycin Ibritumomab Lubiprostone
Co-Trimoxazole Esomeprazole Ibuprofen Maprotiline
Coagulation Factor IX Estazolam Idarubicin Measles, Mumps & Rubella
(Recombinant) Estrogens Idursulfase (MMR) Virus Vaccine
Cocaine Eszopiclone Imatinib Mebeverine
Codeine Etanercept Imiglucerase Mechlorethamine
Colchicine Etelcalcetide Imipenem/Cilastatin Meclofenamate
Colestipol Ethambutol Imipramine Medroxyprogesterone
Crisaborole Ethionamide Immune Globulin IV Mefenamic Acid
Cromolyn Ethosuximide Indapamide Mefloquine
Cyanocobalamin Etodolac Indinavir Meloxicam
Cyclamate Etoricoxib Indomethacin Melphalan
Cyclobenzaprine Evolocumab Infliximab Memantine
Cyclophosphamide Exenatide Insulin Meperidine
Cycloserine Famotidine Insulin Glulisine Mephenytoin
Cyclosporine Febuxostat Interferon Alfa Meprobamate
Cysteamine Felbamate Interferon Beta Mercaptopurine
Cytarabine Felodipine Iodixanol Meropenem
Dacarbazine Fenofibrate Iohexol Mesna
Daclizumab Fenoprofen Iomeprol Metamizole
Dalbavancin Fentanyl Iopromide Metformin
Dapagliflozin Ferumoxytol Ioversol Methadone
Dapsone Fexofenadine Ipilimumab Methamphetamine
Darunavir Finasteride Ipratropium Methazolamide
Dasatinib Flecainide Irbesartan Methimazole
Daunorubicin Flucloxacillin Isavuconazonium Sulfate Methohexital
Decitabine Flumazenil Isoniazid Methotrexate
Deferasirox Fluorides Isotretinoin Methoxsalen
Deferoxamine Fluoxetine Isradipine Methsuximide
Deflazacort Flurbiprofen Itraconazole Methyldopa
Degarelix Fluvoxamine Ivacaftor Methylphenidate
Delafloxacin Folic Acid Ivermectin Methylprednisolone
Delavirdine Foscarnet Ixazomib Metoclopramide
Deoxycholic Acid Fosinopril Ixekizumab Metolazone
Desipramine Fulvestrant Japanese Encephalitis Vaccine Metronidazole
Desloratadine Furazolidone Ketamine Mexiletine
Dexamethasone Furosemide Ketoconazole Micafungin
Dexlansoprazole Gadobenate Ketoprofen Miconazole
Dextroamphetamine Gadodiamide Ketorolac Midazolam
Diazepam Gadopentetate Labetalol Miltefosine
Diclofenac Gadoteridol Lamivudine Minocycline
Dicloxacillin Gadoversetamide Lamotrigine Mirabegron
Dicumarol Ganciclovir Lansoprazole Mitomycin
Diethylstilbestrol Gefitinib Leflunomide Mitotane
Diflunisal Gemfibrozil Lenalidomide Mivacurium
Digoxin Gemifloxacin Lepirudin Moexipril
Dihydrocodeine Gentamicin Lesinurad Montelukast
Moricizine Piroxicam Sparfloxacin Zalcitabine

Moxifloxacin Pitavastatin Spectinomycin Zaleplon
Mycophenolate Pizotifen Spironolactone Zanamivir
Nabumetone Plasma (Human) Blood Streptokinase Zidovudine
Nafarelin Product Streptomycin Ziprasidone
Nalbuphine Pneumococcal Vaccine Sufentanil Zolmitriptan
Nalidixic Acid Polidocanol Sulfadiazine Zolpidem
Naloxone Pomalidomide Sulfamethoxazole Zonisamide
Naproxen Porfimer Sulfasalazine Vasculitis
Naratriptan Potassium Iodide Sulfisoxazole Abatacept
Nefazodone Praziquantel Sulindac Acebutolol
Nelfinavir Prazosin Sulpiride Aceclofenac
Neomycin Prednicarbate Sumatriptan Acenocoumarol
Neostigmine Prednisolone Tacrine Acetaminophen
Nevirapine Prednisone Tacrolimus Acyclovir
Niacin Prilocaine Tartrazine Adalimumab
Nicardipine Primaquine Tedizolid Ado-Trastuzumab Emtansine
Nifedipine Primidone Teicoplanin Aldesleukin
Nilotinib Pristinamycin Telithromycin Alemtuzumab
Nimesulide Probenecid Telmisartan Allopurinol
Nisoldipine Procainamide Tenecteplase Aminosalicylate Sodium
Nitrofurantoin Procarbazine Teniposide Amiodarone
Nitroglycerin Progestins Tenofovir Disoproxil Amitriptyline
Nivolumab Promethazine Terbinafine Amlodipine
Nizatidine Propafenone Terfenadine Amoxapine
Norfloxacin Propofol Teriflunomide Amoxicillin
Obeticholic Acid Propoxyphene Tesamorelin Amphotericin B
Octreotide Propranolol Tetracycline Ampicillin
Ofatumumab Propylthiouracil Thalidomide Anastrozole
Ofloxacin Propyphenazone Thiabendazole Anistreplase
Olanzapine Protamine Sulfate Thimerosal Anthrax Vaccine
Olsalazine Psoralens Thiopental Asparaginase
Omalizumab Quinacrine Thiotepa Aspartame
Ombitasvir/Paritaprevir/ Quinapril Thyrotropin Alfa Aspirin
Ritonavir Quinestrol Tiagabine Atenolol
Omeprazole Quinidine Ticlopidine Atorvastatin
Ondansetron Quinine Tigecycline Azacitidine
Oral Contraceptives Quinupristin/Dalfopristin Tinidazole Azatadine
Oritavancin Rabeprazole Tinzaparin Azathioprine
Oxacillin Ramipril Tirofiban Azithromycin
Oxaliplatin Ranitidine Tizanidine BCG Vaccine
Oxaprozin Rapacuronium Tocilizumab Bendamustine
Oxerutins Remifentanil Tolazamide Bevacizumab
Oxilan Ribavirin Tolbutamide Bexarotene
Oxprenolol Riboflavin Tolcapone Blinatumomab
Oxycodone Rifampin Tolmetin Bortezomib
Oxymorphone Rifapentine Topiramate Bosentan
Paclitaxel Rifaximin Torsemide Bromocriptine
Pantoprazole Risedronate Tosufloxacin Busulfan
Pantothenic Acid Risperidone Tramadol Captopril
Paroxetine Hydrochloride Ritonavir Trazodone Carbamazepine
PEG-Interferon Rituximab Triamcinolone Carbimazole
Pegaptanib Rivaroxaban Trimethadione Carvedilol
Pegaspargase Rivastigmine Trimethoprim Caspofungin
Pemetrexed Rofecoxib Tripelennamine Celecoxib
Penicillamine Ropinirole Troleandomycin Certolizumab
Penicillin G Roxithromycin Trovafloxacin Cevimeline
Penicillin V Rupatadine Urofollitropin Chloramphenicol
Pentamidine Saccharin Valdecoxib Chlordiazepoxide
Pentosan Salmeterol Valsartan Chloroquine
Pentostatin Salsalate Vancomycin Chlorothiazide
Perflutren Saquinavir Vardenafil Chlorpromazine
Permethrin Sebelipase Alfa Varicella Vaccine Chlorpropamide
Perphenazine Secretin Vasopressin Chlorthalidone
Phenobarbital Secukinumab Vedolizumab Chlorzoxazone
Phenolphthalein Sertraline Velaglucerase Alfa Cimetidine
Phenylbutazone Sildenafil Venlafaxine Cinacalcet
Phenytoin Simvastatin Verapamil Ciprofloxacin
Phytonadione Smallpox Vaccine Voriconazole Citalopram
Pilocarpine Sodium Oxybate Warfarin Cladribine
Pipecuronium Sorafenib Yellow Fever Vaccine Clarithromycin
Clindamycin Imatinib Phenylbutazone Abemaciclib

Clorazepate Imipenem/Cilastatin Phenytoin Abiraterone
Clozapine Imipramine Phytonadione Acamprosate
Co-Trimoxazole Imiquimod Piroxicam Acebutolol
Cocaine Immune Globulin IV Potassium Iodide Aceclofenac
Colchicine Indapamide Pramipexole Acetaminophen
Cromolyn Indinavir Pregabalin Acetohexamide
Cyclophosphamide Indomethacin Procainamide Acitretin
Cyclosporine Infliximab Propylthiouracil Adalimumab
Cyproheptadine Influenza Vaccine Psoralens Adenosine
Cytarabine Insulin Pyridoxine Ado-Trastuzumab Emtansine
Daclizumab Insulin Aspart Quinapril Afatinib
Delavirdine Interferon Alfa Quinidine Aflibercept
Diazepam Interferon Beta Quinine Agalsidase
Diclofenac Interferon Gamma Ramipril Albendazole
Didanosine Ipilimumab Ranitidine Albiglutide
Diflunisal Isoniazid Ribavirin Aldesleukin
Digoxin Isotretinoin Rifampin Alectinib
Diltiazem Itraconazole Risedronate Alefacept
Diphenhydramine Ixazomib Ritodrine Alemtuzumab
Disulfiram Ketoconazole Rituximab Alfuzosin
Doxycycline Ketorolac Rivastigmine Alirocumab
Dronedarone Leflunomide Rofecoxib Aliskiren
Efavirenz Leuprolide Simvastatin Allopurinol
Enalapril Levamisole Sirolimus Almotriptan
Enfuvirtide Levetiracetam Sofosbuvir Alogliptin
Ephedrine Levofloxacin Sorafenib Alosetron
Epirubicin Lisinopril Sotalol Alpha-Lipoic Acid
Erlotinib Lithium Spironolactone Alprazolam
Erythromycin Maprotiline Streptokinase Alprostadil
Estrogens MDMA Streptomycin Amantadine
Etanercept Meclofenamate Sulfadiazine Amiloride
Ethacrynic Acid Mefenamic Acid Sulfamethoxazole Amiodarone
Etodolac Mefloquine Sulfasalazine Amisulpride
Etoposide Meloxicam Sulfisoxazole Amitriptyline
Everolimus Melphalan Sulindac Amlodipine
Exemestane Meperidine Tacrolimus Amodiaquine
Ezetimibe Meprobamate Tamoxifen Amoxapine
Famciclovir Mercaptopurine Tartrazine Amoxicillin
Famotidine Mesalamine Telithromycin Anagrelide
Fenbufen Metformin Telmisartan Anidulafungin
Flucloxacillin Methimazole Terbutaline Anti-Thymocyte
Fluorouracil Methocarbamol Tetracycline Immunoglobulin (Rabbit)
Fluoxetine Methotrexate Thalidomide Antihemophilic Factor
Flurbiprofen Methoxsalen Thiamine Apixaban
Fluticasone Propionate Methyldopa Thioridazine Apomorphine
Furosemide Methylphenidate Ticlopidine Apremilast
Gabapentin Metolazone Tinidazole Aprepitant
Gefitinib Minocycline Tocainide Arformoterol
Gemcitabine Mitotane Tocilizumab Aripiprazole
Gemfibrozil Nabumetone Torsemide Armodafinil
Gentamicin Naproxen Trazodone Arsenic
Glatiramer Nelfinavir Tretinoin Artemether/Lumefantrine
Glimepiride Nicotine Trichlormethiazide Artesunate
Glucagon Nifedipine Trimethadione Articaine
Glyburide Nimesulide Trioxsalen Asenapine
Gold & Gold Compounds Nizatidine Triptorelin Atazanavir
Golimumab Ofloxacin Ustekinumab Atenolol
Granulocyte Colony- Olanzapine Valproic Acid Atomoxetine
Stimulating Factor (G-CSF) Omeprazole Vancomycin Atorvastatin
Griseofulvin Oxacillin Vemurafenib Atovaquone/Proguanil
Guanethidine Oxaliplatin Verapamil Avanafil
Heparin Pantoprazole Vinorelbine Avelumab
Hepatitis B Vaccine Paroxetine Hydrochloride Warfarin Axitinib
Heroin PEG-Interferon Zafirlukast Azacitidine
Hydralazine Pembrolizumab Zidovudine Azathioprine
Hydrochlorothiazide Pemetrexed Vertigo Azilsartan
Hydroxychloroquine Penicillamine Abacavir Azithromycin
Hydroxyurea Penicillin V Abaloparatide Baclofen
Ibuprofen Pergolide Abarelix Basiliximab
Icodextrin Phenobarbital Abatacept Bedaquiline
Belatacept Clofarabine Duloxetine Gadoxetate

Belinostat Clofazimine Dutasteride Galantamine
Benazepril Clomipramine Eculizumab Gatifloxacin
Bendamustine Clonidine Edaravone Gefitinib
Benznidazole Clozapine Edrophonium Gemifloxacin
Benzphetamine Co-Trimoxazole Efavirenz Gentamicin
Bepridil Coagulation Factor IX Eflornithine Glatiramer
Betaxolol (Recombinant) Eletriptan Gliclazide
Bezafibrate Cobicistat/Elvitegravir/ Eliglustat Glimepiride
Biperiden Emtricitabine/Tenofovir Elotuzumab Glipizide
Bismuth Disoproxil Eluxadoline Glycopyrrolate
Bisoprolol Codeine Empagliflozin Golimumab
Bleomycin Colesevelam Emtricitabine Goserelin
Blinatumomab Crizotinib Enalapril Granisetron
Bortezomib Crofelemer Entacapone Granulocyte Colony-
Bosentan Cyclobenzaprine Entecavir Stimulating Factor (G-CSF)
Bosutinib Cycloserine Enzalutamide Guanabenz
Botulinum Toxin (A & B) Cyclosporine Eplerenone Guanadrel
Brentuximab Vedotin Cysteamine Epoetin Alfa Guanethidine
Brexpiprazole Cytarabine Eprosartan Guanfacine
Brinzolamide Dabigatran Eribulin Halofantrine
Brivaracetam Daclizumab Escitalopram Haloperidol
Brodalumab Dalbavancin Eslicarbazepine Human Papillomavirus (HPV)
Bromocriptine Dalfampridine Esomeprazole Vaccine
Bupivacaine Dantrolene Estramustine Human Papillomavirus Vaccine
Buprenorphine Dapagliflozin Eszopiclone (Bivalent)
Bupropion Dapsone Etanercept Hydrochlorothiazide
Butorphanol Daptomycin Etravirine Hydrocodone
C1-Esterase Inhibitor Darbepoetin Alfa Everolimus Hydromorphone
Cabazitaxel Darifenacin Evolocumab Hydroxychloroquine
Cabergoline Dasatinib Exenatide Ibandronate
Cabozantinib Daunorubicin Ezetimibe Ibritumomab
Canagliflozin Decitabine Ezogabine Ibrutinib
Canakinumab Deferasirox Factor VIII - von Willebrand Icatibant
Candesartan Deflazacort Factor Icodextrin
Capecitabine Degarelix Famotidine Idebenone
Carbamazepine Delafloxacin Febuxostat Iloperidone
Carbetocin Denileukin Felbamate Iloprost
Carboplatin Denosumab Fentanyl Imatinib
Carfilzomib Desvenlafaxine Ferric Gluconate Imidapril
Cariprazine Deutetrabenazine Ferumoxytol Imiglucerase
Carisoprodol Dexamethasone Fesoterodine Imipramine
Carvedilol Dexketoprofen Finasteride Imiquimod
Caspofungin Dextroamphetamine Fingolimod Immune Globulin IV
Cefditoren Dextromethorphan Flecainide Indapamide
Cefepime Diatrizoate Flibanserin Indinavir
Cefpodoxime Diazepam Flumazenil Indoramin
Ceftaroline Fosamil Diazoxide Fluorouracil Infliximab
Ceftazidime & Avibactam Diclofenac Fluoxetine Influenza Vaccine
Ceftolozane & Tazobactam Dicyclomine Fluphenazine Insulin
Ceftriaxone Diethylpropion Flurbiprofen Insulin Detemir
Cefuroxime Dihydrocodeine Fluticasone Furoate Interferon Alfa
Celecoxib Dihydroergotamine Fluticasone Propionate Interferon Beta
Celiprolol Diltiazem Fluvoxamine Iobenguane
Certolizumab Diphenhydramine Follitropin Alfa/Beta Iodixanol
Cevimeline Dipyridamole Fomepizole Iohexol
Chloroquine Disopyramide Fomivirsen Iomeprol
Chlorpromazine Disulfiram Formoterol Iopromide
Chlorthalidone Docetaxel Fosfomycin Ioversol
Chlorzoxazone Dofetilide Fosphenytoin Ipilimumab
Cholera Vaccine Dolasetron Frovatriptan Irinotecan
Choline Fenofibrate Dolutegravir Fulvestrant Isavuconazonium Sulfate
Cilazapril Donepezil Furazolidone Isocarboxazid
Cilostazol Doxazosin Gabapentin Isosorbide Mononitrate
Cinacalcet Doxepin Gadobenate Isradipine
Cinnarizine Doxercalciferol Gadobutrol Itraconazole
Ciprofloxacin Doxorubicin Gadodiamide Ivabradine
Cisplatin Doxycycline Gadofosveset Ivacaftor
Citalopram Dronabinol Gadopentetate Ivermectin
Clevidipine Dronedarone Gadoteridol Ixabepilone
Clobazam Droxidopa Gadoversetamide Japanese Encephalitis Vaccine
Kanamycin Minocycline Pancrelipase Remifentanil

Ketamine Minoxidil Pandemic Influenza Vaccine Repaglinide
Ketoconazole Mirabegron (H1N1) Ribavirin
Ketorolac Mirtazapine Panitumumab Rifabutin
Lacosamide Mivacurium Panobinostat Rifampin
Lamivudine Mizoribine Pantoprazole Rifapentine
Lamotrigine Moclobemide Paricalcitol Rifaximin
Lansoprazole Modafinil Paroxetine Hydrochloride Rilpivirine
Lapatinib Moexipril Paroxetine Mesylate Riluzole
Latanoprost Montelukast Pasireotide Rimantadine
Ledipasvir & Sofosbuvir Morphine PEG-Interferon Rimonabant
Leflunomide Moxifloxacin Pegaptanib Riociguat
Lenalidomide Moxonidine Pegaspargase Risedronate
Lenvatinib Mupirocin Peginesatide Risperidone
Lesinurad Muromonab-CD3 Pegloticase Ritonavir
Letrozole Mycophenolate Pegvisomant Rituximab
Levetiracetam Nabilone Pembrolizumab Rivaroxaban
Levodopa Nabumetone Pemetrexed Rivastigmine
Levofloxacin Nadolol Pentamidine Rizatriptan
Levomepromazine Nalbuphine Pentazocine Rofecoxib
Levomilnacipran Nalmefene Perampanel Roflumilast
Levonorgestrel Naloxegol Perflutren Rolapitant
Lidocaine Naltrexone Pergolide Romiplostim
Linagliptin Naproxen Perindopril Ropinirole
Linezolid Naratriptan Pertuzumab Ropivacaine
Liothyronine Nateglinide Phendimetrazine Rosuvastatin
Liraglutide Nebivolol Phenelzine Rotigotine
Lisdexamfetamine Nefazodone Phenobarbital Roxatidine
Lisinopril Nelarabine Phenoxybenzamine Rucaparib
Lithium Nelfinavir Phentermine Rufinamide
Lixisenatide Nesiritide Pilocarpine Rupatadine
Lomitapide Netupitant & Palonosetron Pioglitazone Ruxolitinib
Lopinavir Niacin Piracetam Sacubitril/Valsartan
Loratadine Nicorandil Pirfenidone Safinamide
Lorazepam Nifedipine Piroxicam Salmeterol
Lorcainide Nilotinib Pizotifen Saxagliptin
Lorcaserin Nilutamide Pomalidomide Scopolamine
Losartan Niraparib Ponatinib Secnidazole
Lovastatin Nisoldipine Posaconazole Selegiline
Loxapine Nitazoxanide Pramipexole Selenium
Lubiprostone Nivolumab Pramlintide Selexipag
Lumiracoxib Nizatidine Pranlukast Sertraline
Lurasidone Norfloxacin Prasugrel Sibutramine
Maraviroc Nortriptyline Pravastatin Sildenafil
Mazindol Obeticholic Acid Praziquantel Silodosin
MDMA Octreotide Prazosin Simvastatin
Mebendazole Ofloxacin Prednicarbate Sincalide
Mefloquine Olanzapine Prednisolone Sipuleucel-T
Meloxicam Olmesartan Pregabalin Sitaxentan
Memantine Olodaterol Prenylamine Sodium Oxybate
Meperidine Omacetaxine Promazine Sofosbuvir
Mepolizumab Omalizumab Promethazine Solifenacin
Meptazinol Ombitasvir/Paritaprevir/ Propafenone Sonidegib
Mesalamine Ritonavir Propoxyphene Sorafenib
Metamizole Omeprazole Propranolol Spectinomycin
Metaxalone Ondansetron Pseudoephedrine Streptomycin
Metformin Oral Contraceptives Pyrimethamine Strontium Ranelate
Methocarbamol Oritavancin Quetiapine Sucralfate
Methotrexate Orlistat Quinagolide Sugammadex
Methoxyflurane Oxaliplatin Quinapril Sulfadoxine
Methylnaltrexone Oxcarbazepine Quinidine Sulfasalazine
Methylphenidate Oxerutins Quinine Sumatriptan
Methylprednisolone Oxilan Rabeprazole Sunitinib
Metronidazole Oxprenolol Radium-223 Dichloride Suvorexant
Micafungin Oxybutynin Raltegravir Tacrine
Midazolam Oxycodone Ramelteon Tacrolimus
Midostaurin Oxymorphone Ramipril Tadalafil
Mifepristone Paclitaxel Ranolazine Taliglucerase
Miglustat Palbociclib Rasagiline Talimogene Laherparepvec
Milnacipran Paliperidone Reboxetine Tamoxifen
Miltefosine Palonosetron Regadenoson Tamsulosin
Tapentadol Verteporfin Bisoprolol Diltiazem

Tedizolid Vigabatrin Botulinum Toxin (A & B) Dimenhydrinate
Tegafur/Gimeracil/Oteracil Vilazodone Brexpiprazole Diphenhydramine
Tegaserod Vildagliptin Brimonidine Diphenoxylate
Teicoplanin Vismodegib Brinzolamide Dirithromycin
Telavancin Voriconazole Bromocriptine Disopyramide
Telbivudine Vorinostat Brompheniramine Domperidone
Telithromycin Vortioxetine Bumetanide Donepezil
Telmisartan Warfarin Buprenorphine Doxazosin
Temozolomide Zafirlukast Bupropion Doxepin
Tenofovir Disoproxil Zaleplon Buspirone Dronabinol
Terazosin Zanamivir Butorphanol Duloxetine
Terbutaline Ziconotide Cabergoline Dutasteride
Teriparatide Zidovudine Canagliflozin Efavirenz
Tetrabenazine Ziprasidone Captopril Eletriptan
Tetracaine & Oxymetazoline Zofenopril Cariprazine Eltrombopag
Thalidomide Zoledronate Carisoprodol Enalapril
Thiabendazole Zolmitriptan Carvedilol Enfuvirtide
Thioridazine Zolpidem Cefditoren Enoxacin
Thyrotropin Alfa Zonisamide Cefixime Entacapone
Tiagabine Zoster Vaccine Ceftibuten Ephedrine
Tianeptine Zuclopenthixol Celecoxib Epinephrine
Ticagrelor Xerostomia Cetirizine Eprosartan
Tigecycline Abemaciclib Cetuximab Eribulin
Tiludronate Acamprosate Cevimeline Escitalopram
Timolol Acebutolol Chlordiazepoxide Eslicarbazepine
Tinidazole Acetaminophen Chlormezanone Esmolol
Tiotropium Acetazolamide Chlorpheniramine Estazolam
Tipranavir Acitretin Chlorpromazine Eszopiclone
Tizanidine Aclidinium Ciprofloxacin Etravirine
Tocainide Ado-Trastuzumab Emtansine Cisplatin Everolimus
Tocilizumab Afatinib Citalopram Exemestane
Tofacitinib Aflibercept Clarithromycin Ezogabine
Tolcapone Albendazole Clemastine Famotidine
Tolterodine Albuterol Clindamycin Felbamate
Tolvaptan Aldesleukin Clomipramine Felodipine
Topiramate Almotriptan Clonazepam Fenoprofen
Toremifene Alprazolam Clonidine Fentanyl
Torsemide Alprostadil Clorazepate Fesoterodine
Tositumomab & Iodine131 Amantadine Clozapine Flavoxate
Tosufloxacin Amifostine Codeine Flecainide
Trabectedin Amiloride Conivaptan Flibanserin
Tramadol Amisulpride Crofelemer Fluconazole
Trametinib Amitriptyline Cromolyn Flumazenil
Trandolapril Amlodipine Cyclobenzaprine Fluorides
Tranylcypromine Amoxapine Cyproheptadine Fluoxetine
Trastuzumab Amoxicillin Dapagliflozin Fluphenazine
Trazodone Apraclonidine Darifenacin Flurazepam
Treprostinil Aprepitant Dasatinib Flurbiprofen
Trimipramine Arbutamine Daunorubicin Fluvoxamine
Triptorelin Aripiprazole Degarelix Formoterol
Troglitazone Armodafinil Delavirdine Fosfomycin
Trospium Arsenic Desipramine Fosinopril
Trovafloxacin Asenapine Desloratadine Fosphenytoin
Typhoid Vaccine Astemizole Desvenlafaxine Frovatriptan
Ulipristal Atomoxetine Deutetrabenazine Furosemide
Unoprostone Atropine Sulfate Dexamethasone Gabapentin
Urapidil Azatadine Dexchlorpheniramine Gadobenate
Ursodiol Azelastine Dexketoprofen Gadodiamide
Ustekinumab Baclofen Dexlansoprazole Gadopentetate
Valbenazine Balsalazide Dexmedetomidine Gadoteridol
Valproic Acid Bendamustine Dexmethylphenidate Gadoversetamide
Valrubicin Bendroflumethiazide Dextroamphetamine Gadoxetate
Valsartan Benzphetamine Diazepam Ganciclovir
Vancomycin Benztropine Diclofenac Gemifloxacin
Vardenafil Bepridil Dicyclomine Glatiramer
Varenicline Betaxolol Didanosine Glycopyrrolate
Varicella Vaccine Bexarotene Diethylpropion Goserelin
Velaglucerase Alfa Bicalutamide Diflunisal Granisetron
Venlafaxine Bisacodyl Dihydrocodeine Grepafloxacin
Verapamil Bismuth Dihydroergotamine Griseofulvin
Guanabenz Midodrine Pentoxifylline Sucralfate

Guanadrel Mifepristone Perflutren Sugammadex
Guanethidine Miglustat Pergolide Sulfamethoxazole
Guanfacine Milnacipran Perindopril Sulfasalazine
Haloperidol Minocycline Phendimetrazine Sulindac
Hydrocodone Mirabegron Phenelzine Sulpiride
Hydromorphone Mirtazapine Phenobarbital Sumatriptan
Hydroxyzine Mizolastine Phenoxybenzamine Sunitinib
Hyoscyamine Modafinil Phentermine Suvorexant
Ibuprofen Moexipril Pilocarpine Tacrine
Iloperidone Molindone Pimozide Tadalafil
Imatinib Moricizine Pirfenidone Tamoxifen
Imipramine Morphine Piroxicam Tamsulosin
Indapamide Moxifloxacin Pizotifen Tapentadol
Indinavir Moxisylyte Posaconazole Tasimelteon
Insulin Moxonidine Pramipexole Tedizolid
Interferon Alfa Mupirocin Prazepam Telithromycin
Ioversol Nabilone Prazosin Telmisartan
Ipilimumab Nabumetone Pregabalin Temazepam
Ipratropium Nadolol Prochlorperazine Terazosin
Isocarboxazid Nalbuphine Procyclidine Terbutaline
Isoetharine Nalmefene Promethazine Terfenadine
Isoproterenol Naloxone Propafenone Thalidomide
Isotretinoin Naltrexone Propantheline Thiabendazole
Isradipine Naproxen Propofol Thioguanine
Itraconazole Nedocromil Propoxyphene Thioridazine
Ketoprofen Nefazodone Propranolol Thiothixene
Ketorolac Neostigmine Protriptyline Tiagabine
Ketotifen Neratinib Pseudoephedrine Tianeptine
Lamivudine Nevirapine Pyridostigmine Tigecycline
Lamotrigine Nicardipine Pyrimethamine Tiludronate
Lansoprazole Nicotine Quazepam Timolol
Leflunomide Nifedipine Quetiapine Tinidazole
Lenalidomide Nilotinib Quinapril Tiotropium
Lenvatinib Nilutamide Rabeprazole Tizanidine
Letrozole Niraparib Raltitrexed Tocainide
Levocetirizine Nisoldipine Ramipril Tolcapone
Levodopa Nitrofurantoin Ranolazine Tolterodine
Levofloxacin Nitroglycerin Rasagiline Tolvaptan
Levomilnacipran Nivolumab Reboxetine Topiramate
Lisdexamfetamine Nizatidine Regadenoson Toremifene
Lisinopril Norfloxacin Regorafenib Tosufloxacin
Lithium Nortriptyline Remifentanil Tramadol
Lomefloxacin Ofloxacin Reserpine Trametinib
Loperamide Olanzapine Rifaximin Trandolapril
Loratadine Olaparib Riluzole Tranylcypromine
Lorazepam Omacetaxine Rimantadine Trazodone
Lorcaserin Omeprazole Risperidone Tretinoin
Losartan Ondansetron Ritonavir Triamcinolone
Lovastatin Orlistat Rivaroxaban Triamterene
Loxapine Oxaliplatin Rivastigmine Triazolam
Lubiprostone Oxazepam Rizatriptan Trihexyphenidyl
Maprotiline Oxcarbazepine Rofecoxib Trimeprazine
Marihuana Oxprenolol Ropinirole Trimipramine
Mazindol Oxybutynin Rotigotine Tripelennamine
MDMA Oxycodone Rucaparib Triprolidine
Meclizine Oxymorphone Rupatadine Trospium
Meloxicam Oxytocin Salmeterol Trovafloxacin
Meperidine Paliperidone Saquinavir Tryptophan
Mesalamine Palonosetron Scopolamine Ulipristal
Metamizole Panobinostat Selegiline Umeclidinium
Methadone Pantoprazole Sertindole Unoprostone
Methamphetamine Papaverine Sertraline Valbenazine
Methantheline Paricalcitol Sevoflurane Valdecoxib
Methazolamide Paromomycin Sibutramine Valproic Acid
Methyldopa Paroxetine Hydrochloride Sildenafil Valsartan
Methylphenidate PEG-Interferon Solifenacin Vardenafil
Metoclopramide Pembrolizumab Sorafenib Varenicline
Metolazone Pemetrexed Sotalol Vemurafenib
Metronidazole Pentamidine Sparfloxacin Venlafaxine
Mexiletine Pentazocine Spironolactone Verapamil
Vilazodone Vortioxetine Zidovudine Zonisamide

Vitamin A Zalcitabine Ziprasidone Zuclopenthixol
Voriconazole Zaleplon Zolmitriptan
Vorinostat Ziconotide Zolpidem
MAIN CLASSES OF DRUGS
5-HT1 agonist Adrenergic beta-receptor non-narcotic class Ib

Almotriptan agonist Acetaminophen Lidocaine
Eletriptan Arbutamine non-opioid Mexiletine
Frovatriptan Dobutamine Ketorolac Phenytoin
Naratriptan Isoetharine opioid Tocainide
Rizatriptan Isoproterenol Alfentanil class Ic
Sumatriptan Isoxsuprine Dihydrocodeine Flecainide
Zolmitriptan Metoprolol Fentanyl Lorcainide
Meptazinol Moricizine
5-HT3 antagonist Adrenergic beta-receptor
Tapentadol Propafenone
Alosetron antagonist
urinary class II
Dolasetron Betaxolol
Pentosan Acebutolol
Granisetron Carteolol
Phenazopyridine Atenolol
Ondansetron Carvedilol
Esmolol
Palonosetron Esmolol Anesthetic
Labetalol
Labetalol Alfentanil
ACE inhibitor Metoprolol
Levobetaxolol Edrophonium
Benazepril Nadolol
Levobunolol Fentanyl
Captopril Propranolol
Metipranolol Ketamine
Cilazapril Sotalol
Nadolol general
Enalapril class III
Nebivolol Chloral Hydrate
Fosinopril Amiodarone
Penbutolol Propofol
Imidapril Bretylium
Pindolol Sodium Oxybate
Lisinopril Dofetilide
Timolol Sufentanil
Moexipril Dronedarone
inhalation
Perindopril Alkylating agent Ibutilide
Desflurane
Quinapril Altretamine Sotalol
Enflurane
Ramipril Bendamustine Vernakalant
Halothane
Trandolapril Busulfan class IV
Isoflurane
Zofenopril Carboplatin Adenosine
Methoxyflurane
Carmustine Amlodipine
Adrenergic alpha-receptor Sevoflurane
Chlorambucil Bepridil
agonist local
Cisplatin Digoxin
Clonidine Articaine
Cyclophosphamide Diltiazem
Dexmedetomidine Bupivacaine
Dacarbazine Verapamil
Dopamine Cocaine
Estramustine
Ephedrine Levobupivacaine Antibiotic
Ifosfamide
Guanabenz Lidocaine Doripenem
Lomustine
Guanadrel Mepivacaine Ertapenem
Mechlorethamine
Guanethidine Ropivacaine Imipenem/Cilastatin
Melphalan
Guanfacine Tetracaine & Oxymetazoline Meropenem
Mitomycin
Methyldopa Meropenem & Vaborbactam
Oxaliplatin Angiotensin II receptor
Midodrine aminoglycoside
Procarbazine antagonist (blocker)
Mirtazapine Amikacin
Streptozocin Azilsartan
Phenylephrine Gentamicin
Temozolomide Candesartan
Phenylpropanolamine Kanamycin
Thiotepa Eprosartan
Polythiazide Neomycin
Irbesartan
Pseudoephedrine Amphetamine Paromomycin
Losartan
Benzphetamine Streptomycin
Adrenergic alpha-receptor Olmesartan
Dextroamphetamine Tobramycin
antagonist Telmisartan
Diethylpropion anthracycline
Alfuzosin Valsartan
MDMA Bleomycin
Doxazosin Dactinomycin
Methamphetamine Anti-inflammatory
Phenoxybenzamine Daunorubicin
Methylphenidate Amlexanox
Phentolamine Doxorubicin
Pemoline Amodiaquine
Prazosin Epirubicin
Phendimetrazine Clofazimine
Silodosin Idarubicin
Phentermine Colchicine
Tamsulosin Mitomycin
Prenylamine Fluprednisolone
Terazosin Mitoxantrone
Roflumilast
Urapidil Analeptic Peplomycin
Doxapram Antiarrhythmic Valrubicin
Adrenergic alpha2-receptor
Modafinil class Ia beta-lactam
agonist
Disopyramide Ampicillin/Sulbactam
Apraclonidine Analgesic
Procainamide Aztreonam
Brimonidine narcotic
Quinidine Ceftazidime & Avibactam
Tizanidine Dextromethorphan
MAIN CLASSES OF DRUGS Litt’s Drug Eruption & Reaction Manual
Ceftolozane & Tazobactam Nalidixic Acid Pregabalin Dexamethasone

Flucloxacillin Trovafloxacin Primidone Dimenhydrinate
fluoroquinolone rifamycin Tetrazepam Diphenhydramine
Besifloxacin Rifabutin Tiagabine Domperidone
Ciprofloxacin Rifampin Topiramate Dronabinol
Delafloxacin Rifapentine Valproic Acid Droperidol
Enoxacin Rifaximin Vigabatrin Granisetron
Finafloxacin streptogramin Zonisamide Haloperidol
Gatifloxacin Pristinamycin antiepileptic Marihuana
Gemifloxacin Quinupristin/Dalfopristin Brivaracetam Meclizine
Levofloxacin sulfonamide Clobazam Metoclopramide
Lomefloxacin Co-Trimoxazole Eslicarbazepine Nabilone
Moxifloxacin Sulfacetamide Lacosamide Ondansetron
Norfloxacin Sulfadiazine Lamotrigine Palonosetron
Ofloxacin Sulfadoxine Perampanel Perphenazine
Sparfloxacin Sulfamethoxazole Rufinamide Prochlorperazine
Tosufloxacin Sulfisoxazole Vigabatrin Rolapitant
glycopeptide tetracycline hydantoin Scopolamine
Daptomycin Chlortetracycline Ethotoin Trimethobenzamide
Teicoplanin Demeclocycline Fosphenytoin
Antifungal
Vancomycin Doxycycline Mephenytoin
Amphotericin B
imidazole Lymecycline Phenytoin
Caspofungin
Clotrimazole Minocycline oxazolidinedione
Ciclopirox
Ketoconazole Oxytetracycline Paramethadione
Clioquinol
Mebendazole Tetracycline Trimethadione
Econazole
Miconazole Tigecycline succinimide
Efinaconazole
Sertaconazole topical Ethosuximide
Griseofulvin
Thiabendazole Mupirocin Methsuximide
Micafungin
lincosamide Retapamulin
Antidepressant Nystatin
Clindamycin triazole
Bupropion Terbinafine
Clindamycin/Tretinoin Fluconazole
Citalopram azole
Lincomycin Itraconazole
Desvenlafaxine Clotrimazole
macrolide Posaconazole
Duloxetine Fluconazole
Azithromycin Terconazole
Escitalopram Isavuconazonium Sulfate
Clarithromycin Voriconazole
Fluoxetine Itraconazole
Dirithromycin miscellaneous
Fluvoxamine Ketoconazole
Erythromycin Aminosalicylate Sodium
Isocarboxazid Luliconazole
Fidaxomicin Bacitracin
Levomilnacipran Miconazole
Roxithromycin Capreomycin
Milnacipran Posaconazole
Telithromycin Ceftriaxone
Moclobemide Voriconazole
Troleandomycin Chloramphenicol
Nefazodone oxaborole
nitrofuran Cycloserine
Paroxetine Hydrochloride Tavaborole
Furazolidone Dapsone
Phenelzine
Nitrofurazone Ethionamide Antimalarial
Reboxetine
nitroimidazole Fosfomycin Amodiaquine
Selegiline
Benznidazole Isoniazid Artemether/Lumefantrine
Sertraline
Metronidazole Methenamine Artesunate
Tianeptine
Secnidazole Nitrofurantoin Atovaquone
Tranylcypromine
Tinidazole Plicamycin Atovaquone/Proguanil
Tryptophan
oxazolidinone Pyrazinamide Chloroquine
Venlafaxine
Linezolid Quinacrine Halofantrine
Vilazodone
Tedizolid Spectinomycin Hydroxychloroquine
Vortioxetine
penicillin Tigecycline Mefloquine
tetracyclic
Amoxicillin Trimethoprim Primaquine
Maprotiline
Ampicillin Pyrimethamine
Anticonvulsant Mianserin
Ampicillin/Sulbactam Quinacrine
Brivaracetam Mirtazapine
Bacampicillin Quinidine
Carbamazepine tricyclic
Carbenicillin Quinine
Ezogabine Amitriptyline
Cloxacillin Sulfadoxine
Felbamate Amoxapine
Dicloxacillin
Gabapentin Clomipramine Antimycobacterial
Methicillin
Lacosamide Desipramine Bedaquiline
Mezlocillin
Lamotrigine Doxepin Clofazimine
Nafcillin
Levetiracetam Imipramine Dapsone
Oxacillin
Mephenytoin Nortriptyline Ethambutol
Penicillin G
Oxcarbazepine Protriptyline Flucytosine
Penicillin V
Perampanel Trazodone Isoniazid
Piperacillin
Phenacemide Trimipramine Potassium Iodide
Ticarcillin
Phenobarbital echinocandin
quinolone Antiemetic
Phensuximide Anidulafungin
Cinoxacin Aprepitant
Phenytoin
Grepafloxacin Chlorpromazine
Litt’s Drug Eruption & Reaction Manual MAIN CLASSES OF DRUGS
Antineoplastic Cilostazol Cobicistat/Elvitegravir/ Phenobarbital

Anastrozole Clopidogrel Emtricitabine/Tenofovir Primidone
Arsenic Dipyridamole Alafenamide Secobarbital
Asparaginase Eptifibatide Cobicistat/Elvitegravir/ Thiopental
Asparaginase Erwinia Ticagrelor Emtricitabine/Tenofovir
Benzodiazepine
chrysanthemi Tirofiban Disoproxil
Alprazolam
Azacitidine CPTP Darunavir
Chlordiazepoxide
Bexarotene Cangrelor Delavirdine
Clobazam
Cabazitaxel Ticagrelor Didanosine
Clonazepam
Capecitabine thienopyridine Dolutegravir
Clorazepate
Carboplatin Clopidogrel Efavirenz
Diazepam
Cetuximab Prasugrel Emtricitabine
Estazolam
Cisplatin Ticlopidine Enfuvirtide
Flurazepam
Cladribine Fosamprenavir
Antiprotozoal Lorazepam
Cytarabine Hydroxyurea
Atovaquone Midazolam
Dacarbazine Indinavir
Chloroquine Nitrazepam
Dasatinib Lamivudine
Hydroxychloroquine Oxazepam
Decitabine Lopinavir
Mefloquine Prazepam
Denileukin Maraviroc
Nitazoxanide Quazepam
Docetaxel Nelfinavir
Pentamidine Temazepam
Eribulin Nevirapine
Primaquine Tetrazepam
Erlotinib Raltegravir
Pyrimethamine Triazolam
Everolimus Rilpivirine
Quinidine
Floxuridine Ritonavir Bisphosphonate
Quinine
Fludarabine Saquinavir Alendronate
Fluorouracil Antipsychotic Stavudine Etidronate
Gefitinib Amisulpride Tenofovir Disoproxil Ibandronate
Gemcitabine Aripiprazole Zalcitabine Pamidronate
Gemtuzumab Asenapine Zidovudine Risedronate
Hydroxyurea Brexpiprazole Tiludronate
Antiviral
Ibritumomab Carbamazepine Zoledronate
Acyclovir
Imatinib Cariprazine
Amantadine Calcium channel blocker
Irinotecan Chlorpromazine
Cytarabine Amlodipine
Ixabepilone Clozapine
Entecavir Bepridil
Lapatinib Droperidol
Famciclovir Clevidipine
Levamisole Fluphenazine
Foscarnet Diltiazem
Mercaptopurine Haloperidol
Ganciclovir Felodipine
Mitotane Iloperidone
Imiquimod Isradipine
Mitoxantrone Levomepromazine
Oseltamivir Nicardipine
Nelarabine Lithium
Penciclovir Nifedipine
Nilotinib Lurasidone
Peramivir Nimodipine
Nilutamide Mesoridazine
Podophyllotoxin Nisoldipine
Oxaliplatin Molindone
Rimantadine Prenylamine
Paclitaxel Olanzapine
Tenofovir Alafenamide Verapamil
Panitumumab Paliperidone
Trifluridine
Pazopanib Perphenazine Carbonic anhydrase inhibitor
Valacyclovir
Pegaspargase Pimavanserin Acetazolamide
Valganciclovir
Pentostatin Pimozide Brinzolamide
Zanamivir
Porfimer Prochlorperazine Dichlorphenamide
nucleoside analog
Raltitrexed Promazine Dorzolamide
Ribavirin
Sorafenib Quetiapine Ethoxzolamide
Vidarabine
Streptozocin Risperidone Methazolamide
nucleotide analog
Sunitinib Sertindole
Cidofovir CB1 Cannabinoid receptor
Tegafur/Gimeracil/Oteracil Thioridazine
topical antagonist
Temozolomide Thiothixene
Acyclovir Rimonabant
Temsirolimus Trifluoperazine
Docosanol
Teniposide Trimeprazine Central muscle relaxant
Testolactone Valproic Acid Anxiolytic Carisoprodol
Thioguanine Ziprasidone Buspirone Chlormezanone
Topotecan Zuclopenthixol Chlormezanone Chlorzoxazone
Tositumomab & Iodine131 Zuclopenthixol Acetate Meprobamate Cyclobenzaprine
Trabectedin Zuclopenthixol Decanoate Tetrazepam Meprobamate
Trastuzumab Zuclopenthixol Metaxalone
Tretinoin Barbiturate
Dihydrochloride Methocarbamol
Trifluridine & Tipiracil Amobarbital
tricyclic Orphenadrine
Vorinostat Aprobarbital
Loxapine
Butabarbital Cephalosporin
Antiplatelet Antiretroviral Butalbital 1st generation
Abciximab Adefovir Mephobarbital Cefadroxil
Aspirin Amprenavir Methohexital Cefazolin
Cangrelor Atazanavir Pentobarbital Cephalexin
Cephalothin Halobetasol Golimumab Lapatinib

Cephapirin Halometasone Hydroxychloroquine Necitumumab
Cephradine Hydrocortisone Infliximab Nilotinib
2nd generation Loteprednol Leflunomide Panitumumab
Cefaclor Methylprednisolone Methotrexate Pazopanib
Cefamandole Mometasone Minocycline Sorafenib
Cefmetazole Prednicarbate Penicillamine Sunitinib
Cefonicid Prednisolone Rituximab
Eugeroic
Cefotetan Prednisone Sulfasalazine
Armodafinil
Cefoxitin Tixocortol Tocilizumab
Cefprozil Triamcinolone Fibrinolytic
Diuretic
Cefuroxime antagonist Alteplase
Acetazolamide
Loracarbef Mifepristone Anistreplase
Brinzolamide
3rd generation Misoprostol Reteplase
Dorzolamide
Cefdinir Streptokinase
COX-2 inhibitor Eplerenone
Cefditoren Tenecteplase
Celecoxib Isosorbide
Cefixime Urokinase
Etodolac Methazolamide
Cefoperazone
Etoricoxib Spironolactone Gonadotropin-releasing
Cefotaxime
Meloxicam loop hormone (GnRH)
Cefpodoxime
Nimesulide Bumetanide agonist
Ceftazidime
Rofecoxib Ethacrynic Acid Buserelin
Ceftazidime & Avibactam
Valdecoxib Furosemide Goserelin
Ceftibuten
Torsemide Histrelin
Ceftizoxime CYP3A4 inhibitor
potassium-sparing Leuprolide
Ceftriaxone Amiodarone
Amiloride Nafarelin
4th generation Aprepitant
Triamterene Triptorelin
Cefepime Boceprevir
thiazide antagonist
5th generation Chloramphenicol
Bendroflumethiazide Abarelix
Ceftaroline Fosamil Cimetidine
Benzthiazide Cetrorelix
Ceftobiprole Ciprofloxacin
Chlorothiazide Degarelix
Ceftolozane & Tazobactam Clarithromycin
Chlorthalidone Ganirelix
Conivaptan
Cholinesterase inhibitor Cyclothiazide
Dasabuvir/Ombitasvir/ Histamine
Donepezil Hydrochlorothiazide
Paritaprevir/Ritonavir H1 receptor antagonist
Edrophonium Hydroflumethiazide
Delavirdine Alcaftadine
Galantamine Indapamide
Diltiazem Astemizole
Neostigmine Methyclothiazide
Erythromycin Azatadine
Physostigmine Metolazone
Fluconazole Azelastine
Rivastigmine Polythiazide
Fluvoxamine Bepotastine
Succinylcholine Quinethazone
Imatinib Brompheniramine
Tacrine Trichlormethiazide
Indinavir Buclizine
CNS stimulant Itraconazole Dopamine receptor agonist Carbinoxamine
Cocaine Ketoconazole Apomorphine Cetirizine
Dexmethylphenidate Mifepristone Bromocriptine Chlorpheniramine
Dextroamphetamine Nefazodone Cabergoline Cinnarizine
Lisdexamfetamine Nelfinavir Dopexamine Clemastine
Modafinil Norfloxacin Fenoldopam Cyproheptadine
Ombitasvir/Paritaprevir/ Pergolide Desloratadine
Corticosteroid
Ritonavir Pramipexole Dexchlorpheniramine
Alclometasone
Ritonavir Quinagolide Diphenhydramine
Amcinonide
Saquinavir Ropinirole Epinastine
Beclomethasone
Telaprevir Rotigotine Fexofenadine
Betamethasone
Telithromycin Hydroxyzine
Budesonide Dopamine receptor
Verapamil Ketotifen
Ciclesonide antagonist
Voriconazole Levocetirizine
Clobetasol Amisulpride
Loratadine
Cortisone Dermal filler Domperidone
Meclizine
Deflazacort Azficel-T Metoclopramide
Mizolastine
Desonide Calcium Hydroxylapatite Sulpiride
Olopatadine
Desoximetasone
Disease-modifying Endothelin receptor (ETR) Phenindamine
Dexamethasone
antirheumatic drug antagonist Promethazine
Difluprednate
(DMARD) Ambrisentan Pyrilamine
Fludrocortisone
Abatacept Bosentan Rupatadine
Flumetasone
Adalimumab Macitentan Terfenadine
Flunisolide
Azathioprine Sitaxentan Trimeprazine
Fluocinolone
Bucillamine Tripelennamine
Fluocinonide Epidermal growth factor
Certolizumab Triprolidine
Fluprednisolone receptor (EGFR) inhibitor
Chloroquine H2 receptor antagonist
Fluticasone Furoate Cetuximab
Cyclosporine Cimetidine
Fluticasone Propionate Erlotinib
Etanercept Famotidine
Halcinonide Gefitinib
Gold & Gold Compounds Nizatidine
Litt’s Drug Eruption & Reaction Manual MAIN CLASSES OF DRUGS
Ranitidine Mast cell stabilizer Rocuronium Zidovudine

Roxatidine Cromolyn Vecuronium
Oligonucleotide
Lodoxamide
Histone deacetylase (HDAC) Non-nucleoside reverse Defibrotide
Nedocromil
inhibitor transcriptase inhibitor
Pemirolast Opiate agonist
Belinostat Delavirdine
Codeine
Panobinostat Monoamine oxidase (MAO) Efavirenz
Heroin
Romidepsin inhibitor Emtricitabine/Rilpivirine/
Hydrocodone
Vorinostat Isocarboxazid Tenofovir Alafenamide
Hydromorphone
Phenelzine Etravirine
HMG-CoA reductase inhibitor Loperamide
Tranylcypromine Nevirapine
Atorvastatin Meperidine
Rilpivirine
Fluvastatin mTOR inhibitor Methadone
Lovastatin Everolimus Non-steroidal anti- Morphine
Pravastatin Temsirolimus inflammatory (NSAID) Nalbuphine
Rosuvastatin Zotarolimus Aceclofenac Oxycodone
Simvastatin Acemetacin Oxymorphone
Muscarinic antagonist
Aspirin Pentazocine
Hormone Amitriptyline
Benzydamine Propoxyphene
Estradiol Amoxapine
Bromfenac Sufentanil
Levonorgestrel Atropine Sulfate
Celecoxib Tramadol
Oral Contraceptives Benactyzine
Dexibuprofen
Sincalide Benztropine Phosphodiesterase inhibitor
Dexketoprofen
polypeptide Biperiden Apremilast
Diclofenac
Glucagon Chlorpheniramine Avanafil
Diflunisal
Insulin Chlorpromazine Cilostazol
Etodolac
Insulin Aspart Cinnarizine Inamrinone
Etoricoxib
Mecasermin Clidinium Milrinone
Fenbufen
Nesiritide Clomipramine Roflumilast
Fenoprofen
Secretin Darifenacin Sildenafil
Flurbiprofen
Dicyclomine Tadalafil
Immunomodulator Ibuprofen
Diphenhydramine Vardenafil
Aldesleukin Indomethacin
Disopyramide
Efalizumab Ketoprofen Programmed death receptor-
Doxepin
Glatiramer Ketorolac 1 (PD-1) inhibitor
Fesoterodine
Imiquimod Meclofenamate Nivolumab
Flavoxate
Immune Globulin IV Mefenamic Acid Pembrolizumab
Glycopyrrolate
Immune Globulin SC Meloxicam
Hydroxyzine Prostaglandin
Interferon Alfa Metamizole
Hyoscyamine Alprostadil
Interferon Beta Methyl salicylate
Imipramine Dinoprostone
Interferon Gamma Nabumetone
Ipratropium Iloprost
Lenalidomide Naproxen
Maprotiline Treprostinil
Levamisole Nepafenac
Mepenzolate Unoprostone
Natalizumab Nimesulide
Olanzapine
Palivizumab Oxaprozin Prostaglandin analog
Orphenadrine
PEG-Interferon Phenylbutazone Bimatoprost
Oxybutynin
Pimecrolimus Piroxicam Gemeprost
Phenelzine
Pomalidomide Pranoprofen Latanoprost
Prochlorperazine
Sinecatechins Rofecoxib Tafluprost
Procyclidine
Salsalate Travoprost
Immunosuppressant Propantheline
Sulindac
Alefacept Scopolamine Proton pump inhibitor (PPI)
Tenoxicam
Alemtuzumab Solifenacin Dexlansoprazole
Tolmetin
Anti-Thymocyte Globulin Tiotropium Esomeprazole
Valdecoxib
(Equine) Tolterodine Lansoprazole
Anti-Thymocyte Trihexyphenidyl Nucleoside analog reverse Omeprazole
Immunoglobulin (Rabbit) Trospium transcriptase inhibitor Pantoprazole
Azathioprine Umeclidinium Abacavir Rabeprazole
Belatacept Cobicistat/Elvitegravir/
Muscarinic cholinergic agonist Retinoid
Belimumab Emtricitabine/Tenofovir
Bethanechol Acitretin
Cyclosporine Alafenamide
Carbachol Adapalene
Daclizumab Cobicistat/Elvitegravir/
Cevimeline Alitretinoin
Everolimus Emtricitabine/Tenofovir
Methantheline Bexarotene
Fingolimod Disoproxil
Pilocarpine Clindamycin/Tretinoin
Mizoribine Didanosine
Muromonab-CD3 Non-depolarizing Emtricitabine Isotretinoin
Mycophenolate neuromuscular blocker Emtricitabine/Rilpivirine/ Tretinoin
Pirfenidone Atracurium Tenofovir Alafenamide Selective estrogen receptor
Rituximab Cisatracurium Lamivudine modulator (SERM)
Sirolimus Doxacurium Stavudine Chlorotrianisene
Tacrolimus Pancuronium Telbivudine Clomiphene
Thalidomide Pipecuronium Tenofovir Disoproxil Ospemifene
Rapacuronium Zalcitabine Raloxifene
Tamoxifen Levomilnacipran Lapatinib Bosentan

Tibolone Venlafaxine Leflunomide Captopril
Toremifene Vilazodone Lenvatinib Cilazapril
Nilotinib Diazoxide
Selective serotonin reuptake Statin
Nintedanib Enalapril
inhibitor (SSRI) Atorvastatin
Pazopanib Fosinopril
Citalopram Fluvastatin
Ponatinib Hydralazine
Escitalopram Lovastatin
Regorafenib Iloprost
Fluoxetine Pitavastatin
Sorafenib Isosorbide Dinitrate
Fluvoxamine Pravastatin
Sunitinib Isosorbide Mononitrate
Paroxetine Hydrochloride Rosuvastatin
Vandetanib Minoxidil
Paroxetine Mesylate Simvastatin
Nesiritide
Sertraline Vaccine
Sulfonylurea Nitroglycerin
Anthrax Vaccine
Serotonin Acetohexamide Nitroprusside
BCG Vaccine
Buspirone Chlorpropamide Prenylamine
Cholera Vaccine
Sibutramine Gliclazide Quinapril
Diphtheria Antitoxin
serotonin receptor agonist Glimepiride Ramipril
Hemophilus B Vaccine
Almotriptan Glipizide Trandolapril
Hepatitis A Vaccine
Eletriptan Glyburide peripheral
Hepatitis B Vaccine
Frovatriptan Tolazamide Cilostazol
Human Papillomavirus (HPV)
Lorcaserin Tolazoline Papaverine
Vaccine
Rizatriptan Tolbutamide Pentoxifylline
Human Papillomavirus Vaccine
Sumatriptan
Topoisomerase 1 inhibitor (Bivalent) Vitamin
Vortioxetine
Irinotecan Inactivated Polio Vaccine Ascorbic Acid
Zolmitriptan
Topotecan Influenza Vaccine Beta-Carotene
serotonin receptor
Japanese Encephalitis Vaccine Cyanocobalamin
antagonist Topoisomerase 2 inhibitor Measles, Mumps & Rubella Ergocalciferol
Naratriptan Etoposide (MMR) Virus Vaccine Folic Acid
Vortioxetine Teniposide Meningococcal Group B Niacin
serotonin reuptake inhibitor
Trace element Vaccine Niacinamide
Duloxetine
Arsenic Meningococcal Groups C & Y Pantothenic Acid
Trazodone
Selenium & Haemophilus B Tetanus Phytonadione
Vortioxetine
Zinc Toxoid Conjugate Vaccine Pyridoxine
serotonin type 3 receptor
Pandemic Influenza Vaccine Riboflavin
antagonist Tyrosine kinase inhibitor (H1N1) Thiamine
Alosetron Afatinib Pneumococcal Vaccine Vitamin A
Dolasetron Axitinib Sipuleucel-T Vitamin E
Granisetron Bosutinib Smallpox Vaccine
Netupitant & Palonosetron Brigatinib Vitamin D receptor agonist
Typhoid Vaccine
Ondansetron Cabozantinib Dihydrotachysterol
Varicella Vaccine
Palonosetron Ceritinib Doxercalciferol
Yellow Fever Vaccine
serotonin type 4 receptor Crizotinib Paricalcitol
Zoster Vaccine
agonist Dasatinib Xanthine alkaloid
Tegaserod Erlotinib Vasodilator
Aminophylline
serotonin-norepinephrine Gefitinib Ambrisentan
Pentoxifylline
reuptake inhibitor Imatinib Amyl Nitrite
Desvenlafaxine Benazepril
CLASSES OF DRUGS THAT CAN CAUSE IMPORTANT INTERACTIONS
ARBs CYP 3A4 inhibitors Benzphetamine Trazodone

Angiotensin II receptor antagonists Amiodarone Brompheniramine Trimipramine
(blockers) Anastrozole Bupropion Tryptophan
Candesartan Azithromycin Chlorpheniramine Venlafaxine
Eprosartan Cimetidine Citalopram
Irbesartan Clarithromycin Clomipramine NSAIDs*
Losartan Cyclosporine Cocaine Non Steroidal Anti-Inflammatory
Olmesartan Danazol Cyclobenzaprine Drugs
Telmisartan Delavirdine Desipramine Aspirin
Valsartan Dexamethasone Desvenlafaxine Celecoxib
Diltiazem Dextroamphetamine Diclofenac
Anticholinergics Dirithromycin Dextromethorphan Diflunisal
Amoxapine Disulfiram Doxepine Etodolac
Atropine Entacapone Duloxetine Fenoprofen
Benztropine Erythromycin Ephedrine Flurbiprofen
Biperiden Fluconazole Escitalopram Ibuprofen
Chlorpheniramine Fluoxetine Fentanyl Indomethacin
Clomipramine Fluvoxamine Fluoxetine Ketoprofen
Cyproheptadine Grapefruit juice Fluvoxamine Magnesium salicylate
Desipramine Indinavir Imipramine Meclofenamate sodium
Dicyclomine Isoniazid Ketamine Mefenamic acid
Digoxin Ketoconazole Lisdexamfetamine Meloxicam
Diphenhydramine Metronidazole Maprotiline Nabumetone
Disopyramide Mibefradil Mazindol Naproxen
Furosemide Nefazodone MDMA ("Ecstasy") Oxaprozin
Glycopyrrolate Nelfinavir Meperidine Piroxicam
Hyoscyamine Nevirapine Methadone Rofecoxib
Oxybutynin Norfloxacin Methamphetamine Salsalate
Propantheline Omeprazole Methylphenidate Sodium salicylate
Tiotropium Paroxetine Milnacipran Sulindac
Tolterodine Propoxyphene Nefazodone Tolmetin
Quinidine Nortriptyline Valdecoxib
Anticoagulants Quinine Paroxetine
Acenocoumarol Ranitidine Pemoline Statins
Apixaban Ritonavir Phencyclidine HMG-CoA reductase inhibitors
Aspirin Saquinavir Phendimetrazine Atorvastatin
Clopidogrel Sertindole Pheniramine Fluvastatin
Dabigatran Sertraline Phentermine Lovastatin
Dalteparin Troglitazone Phenylephrine Pitavastatin
Fondaparinux Troleandomycin Phenylalanine Pravastatin
Phenindione Valproic acid Propoxyphene Rosuvastatin
Rivarobaxan Protripyline Simvastatin
Ticlopidine MAOIs Pseudoephedrine
Urokinase Monamine Oxidase Inhibitors Reboxetine
Warfarin Amitriptyline Sertraline
Amoxapine Sibutramine
Atomoxetine Tramadol
* Note that acetaminophen (Paracetamol; Tylenol) is not on this list; unlike other common analgesics such as aspirin and ibuprofen, it has no anti-
inflammatory properties, and so it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs. Acetaminophen relieves
pain in mild arthritis but has no effect on the underlying inflammation, redness and swelling of the joint. It belongs to a class of drugs called analgesics
(pain relievers) and antipyretics (fever reducers) and is thought to relieve pain by elevating the pain threshold (that is, by requiring a greater amount
of pain to develop before it is felt). It reduces fever through its action on the heat-regulating center of the brain; specifically, it tells the center to
lower the body’s temperature when the temperature is elevated.
CLASS REACTIONS*
ACE INHIBITORS
B C E F L P Q R T Z =
SKIN
Anaphylaxis [1] [1] • [1] • ü

Angioedema [8] [45] [73] [3] [43] [6] [9] [11] [3] [1] üü
(15%) (70%)
Bullous dermatitis [1] [1]
Bullous pemphigoid [2] [2]
Dermatitis [3] [1] [1]
Diaphoresis [1] [1] • • • [3] [2] ü

DRESS syndrome [2] [1]
Edema [1] • • [4] [1] • ü

Erythema [1] [1] • • [1] ü
Erythema multiforme • •
Erythroderma [2] [1] [1]
Exanthems [1] [19] [9] [4] [1] [1] ü

(10%)
Exfoliative dermatitis [4] • [2] •
Facial edema [1] • [1]
Jaundice [1] [1]
Kaposi’s sarcoma [2] [2] [1]
Lichen planus pemphigoides [2] [3]
Lichenoid eruption [12] [2] [2]
Linear IgA [1] [5]
Lupus erythematosus [8] [2] [1]
Mycosis fungoides [2] [1]
Palmar–plantar pustulosis [1] [1]
Pemphigus [1] [23] [10] [1] [1] [1] • ü
B Benazepril; C Captopril; E Enalapril; F Fosinopril; L Lisinopril; P Perindopril; Q Quinapril; R Ramipril; T Trandolapril; Z Zofenopril
These tables concentrate on skin, hair, nails and mucosal reactions.

* The following conventions are followed in these tables:
• reaction noted (package inserts)
[3] number of published reports of a reaction
(8%) highest incidence that has ever been noted or reported
? 20 reports or over or an incidence of 20% or over recorded for this reaction for a minority of drugs in the class
ü at least half the drugs in the class selection have this reaction noted or reported
üü all drugs in the class selection have this reaction noted or reported
Note: reactions noted or reported for only one drug in a class selection have been excluded
Litt’s Drug Eruption & Reaction Manual © 2018 by Taylor & Francis Group, LLC 353
ACE INHIBITORS CLASS REACTIONS
B C E F L P Q R T Z =
Pemphigus foliaceus [1] [2] [2] [1] [2] [1] [1] [1] [1] ü
Peripheral edema [3] [2] [1] [3] [3] ü
Photosensitivity • [3] [2] • • [2] [2] ü
Pityriasis rosea [6] [2]
Pruritus [1] [8] [3] [1] • (<10%) [7] [3] • ü

(10%)
Pseudolymphoma [2] [1] [1]
Psoriasis [8] [3] [1] • [1] ü

Purpura [1] [1] [2] • • ü
Rash [1] [12] [5] [1] [5] [1] [5] [4] • • üü
(4–7%) (<10%)
Stevens–Johnson syndrome [1] • [1]
Toxic epidermal necrolysis [3] •
Urticaria [1] [9] [5] • [2] • • ü

(7%)
Vasculitis [7] [2] [1] • [1] ü
Xerosis [1] •
HAIR
Alopecia [4] [1] [1] • (<10%) ü

NAILS
Nail dystrophy [2] [1]
MUCOSAL
Burning mouth syndrome [1] [1] [1]
Glossitis [3] •
Glossopyrosis [1] [1]
Oral burn [1] [1]
Oral ulceration [4] [2]
Sialorrhea [1] •
Tongue edema [2] [2] [2]
Xerostomia [1] • • • • • • • ü
B Benazepril; C Captopril; E Enalapril; F Fosinopril; L Lisinopril; P Perindopril; Q Quinapril; R Ramipril; T Trandolapril; Z Zofenopril
354 Litt’s Drug Eruption & Reaction Manual © 2018 by Taylor & Francis Group, LLC
CLASS REACTIONS ANTIARRHYTHMICS
ANTIARRHYTHMICS
A Di Dr F I L Pn Pf Pr Q S =
SKIN
Acneform eruption • [2] [2]
AGEP [1] [2]
Anaphylaxis [2] [2] [7] [1]
Angioedema [2] [3] [1] [1] [2] • ü

Dermatitis • (5%) [27] [1] [2] [4] ü

[1] (6%)
Diaphoresis [2] • [1] [1] • • ü
Eczema (5%) [3] [2]
[1]
Edema (<10%) • • [2] • (5%) ü
Erythema (5%) [3] [1] [1]
Erythema multiforme [1] [2] [1] [1]
Erythema nodosum [2] [1] [1]
Exanthems [5] [1] [1] [1] [2] [5] [1] [4] [6] ü
(<5%) (8%) (17%)
Exfoliative dermatitis [1] • [2] [1] [5]
Fixed eruption [1] [2] [1] [2]
Hypersensitivity [1] [1] [9] [2] [1]
Leukocytoclastic [1] [1]

vasculitis
Lichen planus [1] [7]
Lupus erythematosus [5] [3] [1] [175] [3] [2] [35] ü

(5%) (15–20%)
Necrosis [1] [3]
Photosensitivity [41] [1] [1] [1] [1] [21] • ü

(10–75%)
Phototoxicity [3] [1] [1] [1]
Pigmentation [68] [1] [3] ?

(<10%)
Pruritus [2] • (5%) • [3] • • [1] [3] (<10%) ü
(<5%) [1]
Psoriasis [2] [2] [2] [21] [5] [3] ü
Purpura [1] [1] [1] [3] • [1] [13] ü
Rash [1] • [8] • • • • [2] (<10%) • ü
(<10%) (<10%)
A Amiodarone; Di Disopyramide; Dr Dronedarone; F Flecainide; I Ibutilide; L Lidocaine; Pn Procainamide; Pf Propafenone; Pr Propranolol;

Q Quinidine; S Sotalol
ANTIARRHYTHMICS CLASS REACTIONS
A Di Dr F I L Pn Pf Pr Q S =
Raynaud’s [3] • ?
phenomenon (59%)
Sjögren’s syndrome [1] [1]
Stevens–Johnson • [1] [2]

syndrome
Toxic epidermal [2] [1] [1] [2]

necrolysis
Toxicity [5] [1] [1] [3] [1]
Urticaria [1] • [5] [1] [1] [3] [1] ü

(<5%)
Vasculitis [6] [1] [5] [5] [1]
HAIR
Alopecia [5] • • [6] [1] • ü

MUCOSAL
Oral lesions [1] [1] ?

(40%) (>5%)
Oral mucosal eruption [1] [2]
Oral ulceration [1] [1] [1]
Sialorrhea (<10%) [1]
Xerostomia [2] • • [1] • ?

(40%)
A Amiodarone; Di Disopyramide; Dr Dronedarone; F Flecainide; I Ibutilide; L Lidocaine; Pn Procainamide; Pf Propafenone; Pr Propranolol;

Q Quinidine; S Sotalol
CLASS REACTIONS ANTIBIOTICS, MACROLIDE
ANTIBIOTICS, MACROLIDE
A C E =
SKIN
AGEP [3] [2] ü

Anaphylaxis [2] [2] [2] üü
Angioedema [1] [1] [1] üü
Dermatitis [1] [4] ü
Exanthems [3] [2] [4] üü
(<5%)
Fixed eruption [3] [6] ü
Hypersensitivity [3] [3] [3] üü
(<10%)
Jarisch–Herxheimer [2] [1] ü
reaction
Pruritus [3] [1] ü

Pustules [1] [1] ü
Rash [6] [2] [3] üü
(2–10%)
SDRIFE [1] [2] ü
Stevens-Johnson [6] [1] [7] üü
syndrome
Toxic epidermal [4] [7] ü

necrolysis
Toxicity [1] [1] ü

Urticaria [2] [1] [4] üü
Vasculitis [1] [3] [1] üü
HAIR
Alopecia [1] [1] ü

MUCOSAL
Gingival [1] [1] ü

hyperplasia/hypertrophy
A Azithromycin; C Clarithromycin; E Erythromycin
ANTICONVULSANTS CLASS REACTIONS
ANTICONVULSANTS
B C G La Le O Phb Phy Ti To V Z =
SKIN
Acne keloid [1] [2]
Acneform eruption [1] • [1] • [1] [8] • • • ü

AGEP [5] [1] [1] [1] [5] [1] ü
Angioedema • [5] [1] • [2]
(<10%)
Anticonvulsant [19] [2] [17] [1] [10] [10] [6] ü
hypersensitivity
syndrome
Bullae [1] [1]
Bullous dermatitis [4] [1] [5] [1] [1]
Dermatitis [7] [1] • •
Diaphoresis (<10%) • • [1] • • [1] • ü

DRESS syndrome [48] [17] [7] [6] [13] [32] [9] [3] ü
(77%) (11%) (6%) (68%)
Ecchymoses • • • (<6%) [4] • ü
(<5%)
Eczema [2] • • • •
Edema [5] [1] • [1] • • [3] • ü

Epidermolysis bullosa [1] [1]
Erythema [1] [2] [2]

(~10%)
Erythema multiforme [16] [4] [2] [7] [11] [3] ü
Erythroderma [12] [1] [2] [9] [3]
(16%) (6%)
Exanthems [35] [2] [18] [1] [4] [13] [22] • [1] [3] • ü
(17%) (20%) (70%) (71%) (14%)
Exfoliative dermatitis [24] [1] [6] [15] • ?
Facial edema [2] • • • [1] • • ü
Fixed eruption [10] [1] [1] [9] [5] [2] [1] ü
Furunculosis • (<5%)
Granuloma annulare [1] [1]
Hand–foot syndrome [1] [1]
Hot flashes [1] (<10%) • (<10%)
Hyperhidrosis [1] •
Hypersensitivity • [71] [1] [29] [6] [12] [47] [5] [4] ü

(<10%) (23%)
B Brivaracetam; C Carbamazepine; G Gabapentin; La Lamotrigine; Le Levetiracetam; O Oxcarbazepine; Phb Phenobarbital; Phy Phenytoin;
Ti Tiagabine; To Topiramate; V Valproic Acid; Z Zonisamide
CLASS REACTIONS ANTICONVULSANTS

vasculitis
Lichenoid eruption [8] [1]
Linear IgA [1] [8]
Lupus erythematosus [35] [4] [2] [19] [5] [1] ü

Lymphadenopathy [1] [1] • • •
Lymphoma [2] [6]
Lymphoproliferative [5] [1]

disease
Mycosis fungoides [3] [1] [1] [7]
Neoplasms [1] •
Oligohydrosis [1] [8]
Pemphigus [3] [1] [2]
Peripheral edema [1] [12] [1] [1] • (<5%) • ü

(8%)
Petechiae [1] • • [1] •
(<5%)
Photosensitivity [9] [2] [1] [1] • • [1] ü
Pigmentation [1] [4] • •
Pruritus [7] [1] [3] [1] [1] [5] • [3] [1] [1] ü
(>5%) (2–6%)
Pseudolymphoma [17] [1] [1] [31] [2] ?
Psoriasis [1] [1] •
Purpura [8] [1] [1] • [2] [4] • [2] • ü

Pustules [5] [1] [3] •
Rash [30] [2] [53] [5] [11] [4] [13] [2] [3] [7] [6] ü
(12%) (12–22%) (9%) (17%) (5%) (6%) (>5%) (7%)
Scleroderma [1] [1]
Sjögren’s syndrome [1] [1] [1] [1]
Stevens-Johnson [98] [2] [49] [3] [10] [21] [58] [11] [3] ü
syndrome (68%) (30%) (15%) (68%)
Toxic epidermal [88] [51] [2] [4] [26] [65] [7] [1] ü
necrolysis (68%) (13%) (13%) (68%)
Toxicity [2] [1] [1]
Toxicoderma [1] [1]
Urticaria [14] [1] [2] [1] [5] • [1] [1] ü

(7%)
Vasculitis [7] [1] [1] [1] [11] [3] ü
Vesiculobullous • •
eruption
ANTICONVULSANTS CLASS REACTIONS
Xerosis • • [1] [1]
HAIR
Alopecia [7] [2] [2] [3] • [2] [22] • ü

(~6%) (<10%)
Hirsutism [1] • [8] • [2] • ü
(25%) (13%) (60%)
Poliosis [1] [1]
NAILS
Nail changes [2] •
Nail hypoplasia [1] [2] [3]
Nail pigmentation [1] [2]
Onychomadesis [1] [1]
MUCOSAL
Epistaxis • •
Gingival [1] • [1] [4] [57] • [2] [8] • ü

hyperplasia/hypertrophy (16%) (16–94%) (42%)
Gingivitis • • • • • • ü
Glossitis • (<5%) •
Halitosis • [1]
Mucocutaneous [4] [2]

eruption
Mucocutaneous lymph [2] [1]

node syndrome
Oral ulceration [2] [1] [1] [1] • • ü

Rectal hemorrhage • • •
Sialorrhea • • [1]
(4–5%)
Stomatitis • • • (<5%) •
Ulcerative stomatitis • •
Xerostomia [1] (6%) • [1] [1] [5] [2] • ü

(5%) (16%) (<5%)
CLASS REACTIONS ANTIDEPRESSANTS, TRICYCLIC
ANTIDEPRESSANTS, TRICYCLIC
Ami Amo C I N T =
SKIN
Angioedema [1] [1]
Dermatitis [1] [1]
Diaphoresis [1] (<10%) [2] [8] (<10%) [1] üü

(<10%) (43%) (25%) (<10%)
Edema [1] (<10%) • [1] ü

Exanthems [2] [6]
(6%)
Fixed eruption [1] [1]
Hypersensitivity [1] [2]
Lupus erythematosus [1] [1]
Photosensitivity [3] • [3] [3] [2] • üü

Pigmentation [4] [1] [13] ü
Pruritus [3] [1] [1] [6] ü
(6%)
Purpura [2] • [3] ü
Rash (<10%) (8%)
Urticaria • [1] [6] ü

Vasculitis [1] [1] [1] ü
HAIR
Alopecia [1] • • [2] • • üü

Alopecia areata [1] [1]
MUCOSAL
Stomatitis [1] [2]
Xerostomia [16] [1] [6] [16] [9] [2] üü

(79%) (14%) (84%) (21%) (<10%) (<10%)
Ami Amitriptyline; Amo Amoxapine; C Clomipramine; I Imipramine; N Nortriptyline; T Trimipramine;
ANTIHISTAMINES (H1) CLASS REACTIONS
ANTIHISTAMINES (H1)
Ce Chl Des Dy Fex H Lev Lor O P =
SKIN
AGEP [1] [1] [1] [3]
Anaphylaxis [2] [1] [4] [2] • [1] ü

Angioedema • (<10%) [1] [3] [1] • ü
Bullous dermatitis • •
Dermatitis • [4] [4] [1] [1] • [3] ü

(<10%)
Desquamation [1] [1]
Diaphoresis • •
Eczema [2] [1]
Edema • •
Erythema multiforme [2] • [2]
Exanthems [1] [1] [3] [1]
Fixed eruption [6] [4] [3] [3] [3] [1] [1] ü

Palmar erythema [1] [1]
Photosensitivity • (<10%) [3] • • [12] ü

Phototoxicity • [1] [1] [1]
Pruritus [1] [1] [2] [1]
Purpura • [1] [1] • [2] ü

Rash • • • [1] [1] ü
Stevens-Johnson [1] [1]
syndrome
Toxic epidermal [3] [1] [2]

necrolysis
Toxicity [2] [1]
Urticaria [9] [2] [3] [4] [1] [4] [3] ü

Xerosis • •
HAIR
Alopecia • •
MUCOSAL
Oral ulceration [1] [1]
Sialorrhea • •
Stomatitis • •
Xerostomia [2] (<10%) [5] [1] [4] • [9] [2] ü

(6%) (<10%) (12%) (<10%)
Ce Cetirizine; Chl Chlorpheniramine; Des Desloratadine; Dy Diphenhydramine; Fex Fexofenadine; H Hydroxyzine; Lev Levocetirizine;
Lor Loratadine; O Olopatadine; P Promethazine
CLASS REACTIONS ANTIMALARIALS
ANTIMALARIALS
Amo A/L Art A/P C H M P Quc Qud Qun S =
SKIN
Acneform eruption [2] [2]
AGEP [1] [1] [22] [1] [2] ?

(25%)
Anaphylaxis [1] [2] •
Angioedema [1] [1] • [2] • • [1] ü

Bullous dermatitis [2] [2] [1]
Dermatitis [1] [2] [1] • [4] [6] ü

DRESS syndrome [2] [2] [1]
Erythema [2] [1] [1]
Erythema annulare [2] [3]

centrifugum
Erythema multiforme [2] • [2] [4] [1] [2] [3] ü

Erythema nodosum [1] [1]
Erythroderma [3] [3]
Exanthems [1] [3] [4] [1] [3] [3] [6] [3] [1] ü
(<5%) (<5%) (30%) (80%) (17%) (<5%)
Exfoliative dermatitis [4] [3] [1] [2] [3] [5] [2] [3] ü
(8%)
Fixed eruption [1] • • [3] [3] [2] [12] [2] ü
Hypersensitivity [1] [1] [1] [1] (>10%)
Lichen planus [1] [7] [3]
Lichenoid eruption [6] [4] [2] [6] [6] [3] ü

(12%)
Livedo reticularis [6] [3]
Lupus erythematosus [35] [1] ?

Lymphoproliferative [1] [1] [1]
disease
Ochronosis [2] [1]
Pemphigus [1] [1]
Photosensitivity [8] [6] [3] [1] [21] [19] [2] ü

(<10%) (>10%)
Phototoxicity [1] [1] [3] [1]
Pigmentation [15] [19] [5] [9] [3] [6] ü

(<10%)
Pruritus [3] [2] [3] (<10%) [36] [13] [2] [2] • [3] [1] [2] üü
(47%) (47%) (4–10%)
Psoriasis [18] [13] [2] [1] [5]
Amo Amodiaquine; A/L Artemether/Lumefantrine; Art Artesunate; A/P Atovaquone/Proguanil; C Chloroquine; H Hydroxychloroquine; M Mefloquine;
P Pyrimethamine; Quc Quinacrine; Qud Quinidine; Qun Quinine; S Sulfadoxine
ANTIMALARIALS CLASS REACTIONS
Amo A/L Art A/P C H M P Quc Qud Qun S =
Purpura [1] [1] [1] [13] [13] [1] ü

Pustules [1] [1] [1] [1] [1]
Rash [6] [1] [4] [1] • [1] (<10%) [1] • ü

(11%) (<10%) (<10%)
Stevens-Johnson [1] [4] [1] [2] [25] [2] [24] ü
syndrome (<10%) (<10%)
Thrombocytopenic [2] [8]

purpura
Toxic epidermal [5] [3] [2] [15] [2] [3] [17] ü

necrolysis
Toxicity [2] [1]
Urticaria [1] [2] [1] [1] [4] [2] [1] [1] [1] [2] ü
Vasculitis [1] [3] [5] [5]
HAIR
Alopecia [1] [2] • [2] [1] ?

(80%)
Hair pigmentation [10] [8]
(<10%)
NAILS
Discoloration [1] [1]
Nail pigmentation [2] [3] [2]
MUCOSAL
Aphthous stomatitis [1] [1] [1] [1]
Gingival pigmentation [1] [1]
Glossitis • •
Oral edema [1] [1] [1]
Oral pigmentation [12] [7] [4] [1]
Oral ulceration [3] [1] [1]

(6%)
Stomatitis • [2] [1]
Amo Amodiaquine; A/L Artemether/Lumefantrine; Art Artesunate; A/P Atovaquone/Proguanil; C Chloroquine; H Hydroxychloroquine; M Mefloquine;
P Pyrimethamine; Quc Quinacrine; Qud Quinidine; Qun Quinine; S Sulfadoxine
CLASS REACTIONS ANTIPSYCHOTICS
ANTIPSYCHOTICS
Ap As Chl Clo H L O Pal Per Q R Z =
SKIN
Acneform eruption [1] •
AGEP [1] [1] [1]
Anaphylaxis [1] [1] •
Angioedema [1] [1] [2] [1] • [2] [6] [2] ü

Bullous dermatitis [1] •
Candidiasis • •
Dermatitis [1] • • [1]
Diaphoresis [4] [2] • (<10%) • [1] ü

(31%)
Ecchymoses • •
Eczema • • [1] [1] •
Edema • [3] • [1] [3]
Erythema multiforme • • [1]
Exanthems [8] [2] • [1] [2] • ü

(13%)
Exfoliative dermatitis • •
Facial edema [1] • • •
Fixed eruption • [1]
Furunculosis • •
Lichenoid eruption [1] [1] •
Lupus erythematosus [12] [4] [4] [2]
Peripheral edema [1] [5] [4] [5] [4] • ü

(<10%) (16%)
Photosensitivity [22] [1] [3] • • [2] • ü
(<10%) (<10%)
Pigmentation [16] • [1] • •
Pruritus [2] • • • • [1] • ü

(<10%)
Pseudolymphoma [1] [1]
Psoriasis [2] •
Purpura [6] • (<10%) •
Pustules [1] [1]
Ap Aripiprazole; As Asenapine; Chl Chlorpromazine; Clo Clozapine; H Haloperidol; L Lurasidone; O Olanzapine; Pal Paliperidone; Per Perphenazine;
Q Quetiapine; R Risperidone; Z Ziprasidone;
ANTIPSYCHOTICS CLASS REACTIONS
Ap As Chl Clo H L O Pal Per Q R Z =
Rash [2] (<10%) [2] • • [2] [1] (<10%) • [1] • ü

(7%)
SDRIFE [1] [1]
Seborrhea • •
Seborrheic dermatitis [4] [2]

syndrome
Sweet’s syndrome [1] [1]
Ulcerations • •
Urticaria [4] • • [1] [2] [1] ü

(5%)
Vasculitis [3] • [1]
Vesiculobullous • •
eruption
Xerosis • • •
HAIR
Alopecia [1] [3] [1] [2] •
Alopecia areata [1] [2]
MUCOSAL
Epistaxis (<10%) [1] •
Gingival bleeding [1] •
Gingivitis • [1] • [1]
Glossitis • •
Glossodynia [1] •
Nasal congestion • [1]
Oral ulceration • •
Sialorrhea [5] [1] [75] [1] • [4] [2] [3] [11] • ü

(4–11%) (30–80%) (<6%) (13%)
Stomatitis • • •
Tongue edema • • • • •
Tongue pigmentation • •
Xerostomia [7] [1] [1] [3] [4] [11] [1] [22] [7] [1] ü
(15%) (<10%) (6%) (21%) (19%) (31%) (18%) (<5%)
Ap Aripiprazole; As Asenapine; Chl Chlorpromazine; Clo Clozapine; H Haloperidol; L Lurasidone; O Olanzapine; Pal Paliperidone; Per Perphenazine;
Q Quetiapine; R Risperidone; Z Ziprasidone;
CLASS REACTIONS BENZODIAZEPINES
BENZODIAZEPINES
A Cln Clo D L M O =
SKIN
Acneform eruption [1] [1]
Anaphylaxis [1] [1]
Angioedema [1] [1] [1] [1] ü

Dermatitis [5] (<10%) (<10%) [3] (<10%) (<10%) ü

(<10%)
Diaphoresis (16%) [1] (>10%) (>10%) (>10%) (>10%) ü
(>10%)
Edema (5%) [2]
Erythema multiforme [1] [1] [1]
Exanthems [1] [1] [1] [6] ü

Exfoliative dermatitis [1] [2]
Fixed eruption [2] [1] [1]
Peripheral edema [1] •
Photosensitivity [4] [1]
Pruritus [2] [1] [3]

(<10%)
Purpura [1] [4]
Rash [4] (>10%) (>10%) [2] (>10%) • (>10%) üü

(11%) (>10%)
Urticaria [1] [1] [2]
Vasculitis [1] [1]
MUCOSAL
Sialopenia (33%) (>10%) (>10%) (>10%) (>10%) ü

Sialorrhea • (<10%) (<10%) [1] • (<10%) ü
Xerostomia [6] [1] (>10%) (>10%) (>10%) (>10%) ü
(15%) (>10%)
A Alprazolam; Cln Clonazepam; Clo Clorazepate; D Diazepam; L Lorazepam; M Midazolam; O Oxazepam
BETA BLOCKERS CLASS REACTIONS
BETA BLOCKERS
A B C N P S =
SKIN
Anaphylaxis [2] [1]
Cold extremities [1] [6] ?

(36%)
Dermatitis [1] [1] [2] ü
Diaphoresis • [1] • ü
Edema [1] (5%)
Fixed eruption [1] [1] [1] ü

vasculitis
Lichenoid eruption [1] [1] [3] [1] ü

Lupus erythematosus [2] [1] [2] ü
Necrosis [3] [3]
Peripheral edema (<10%) •
Photosensitivity [1] •
Pruritus (<5%) [1] (<10%) ü

Psoriasis [7] [1] [21] [3] ü
Rash [1] (<10%) • [2] • ü
(<10%)
Raynaud’s [2] (<10%) [3] • ü
phenomenon (59%)
Urticaria [2] [3]
Vasculitis [1] [1]
HAIR
Alopecia [1] [6] • ü

MUCOSAL
Xerostomia • [1] • ü
A Atenolol; B Bisoprolol; C Celiprolol; N Nebivolol; P Propranolol; S Sotalol
CLASS REACTIONS BIOLOGICS
BIOLOGICS
Ald Alm Be Bo C D E G Ib In Ip L P R =
SKIN
Acne keloid [1] [2]
Acneform eruption [6] [62] [2] [27] [32] [2] • [1] [1] [18] ü
(83%) (97%) (<10%) (73–80%) (66–85%) (81%)
AGEP [1] [1] [1] [7]
Anaphylaxis • [5] [1] [1] [1] [1] [7] ü

(13%) (30%)
Angioedema [2] • [1] [3] [1] [4]
(11%)
Bullae [1] [1]
Bullous dermatitis [1] • [1] [4] [1]
Burning [1] [1]
Carcinoma [2] [1]
Cellulitis • [1] (5%) [1]
Dermatitis [2] [1] [1] [4] [1] [4] [1] [12] [1] [2] ü
(80%) (<10%) (30%) (6%) (12%)
Dermatomyositis [1] [1] [2]
Desquamation [1] [1] [3] [1] [2] [3] ?

(8%) (89%) (39%) (13%)
Diaphoresis (13%) [1] [2]
(15%)
DRESS syndrome [2] [3] [1] [2]
Ecchymoses [1] [1]

(16%) (16%)
Eczema [1] (<10%) [1] [1] [6] [1] [2] ü
(39%)
Edema [3] [1] (23%) [6] [1] [35] [2] [1] [1] [1] ü
(47%) (15%) (38%) (80%) (15%) (10%) (15%)
Embolia cutis [1] [1]
medicamentosa
(Nicolau syndrome)
Erythema [5] [1] [1] [2] [3] [2] (18%) [1] [5] [2] [3] (5%) [5] [2] üü
(41%) (14%) (<10%) (65%) (16%)
Erythema [1] [1] [2] [1] [1]
multiforme (16%) (16%)
Erythema nodosum [3] • [1] [1]

(>5%)
Exanthems [5] [1] [1] [5] [3] [3] [9] [3] [5] [3] [1] ü
(16%) (8%) (21%) (20%) (16%)
Ald Aldesleukin; Alm Alemtuzumab; Be Bevacizumab; Bo Bortezomib; C Cetuximab; D Dasatinib; E Erlotinib; G Gefitinib; Ib Imatinib; In Interferon
Alfa; Ip Ipilimumab; L Lenalidomide; P Panitumumab; R Rituximab
BIOLOGICS CLASS REACTIONS
Exfoliative [1] [1] [1] [4] [1] [2] ?

dermatitis (18%) (25%)
Facial edema • [1] [3] [1]

(<10%)
Fissures [4] [1] [4] ?
(14%) (21%)
Folliculitis [2] [13] [9] [4] [1] [1] [2] [3] ü
(83%) (11%) (7%)
Graft-versus-host [1] [1] [1] [1] [2] ?
reaction (14%) (43%)
Granulomas [1] [1] [3]
Hand–foot [12] [5] [1] [3] [2] [3] [1] [1] [3] ü
syndrome (57%) (6%) (30–60%) (10%) (23%)
Hematoma • [1] [1]
Herpes [2] (<10%)

(16%)
Herpes simplex [2] [2] [2]
(6%)
Herpes zoster [3] [13] [7]
(9%) (10–
15%)
Hyperhidrosis [1] [1] [1] [2]
(8%) (<10%) (11%)
Hypersensitivity [1] [8] • [1] [1] [5]
(7%)
Kaposi’s sarcoma [1] [2] [3]
Keratoses [1] [1]
Lesions [1] [1]

(8%)
Linear IgA [4] [3]
Livedo reticularis [1] [2]
Lupus [1] [1] [1] [1] [17] [1]

erythematosus
Lupus syndrome [1] [2] [1] [1]
Lymphoma [2] [1]
Malignancies [1] [6]
Malignant • [1]
lymphoma
Necrolysis [1] [1]
Necrosis [2] [2] [1] [6] [1]
Neutrophilic [1] [3]

eccrine hidradenitis
Panniculitis [4] [3]
Papulopustular [7] [9] [3] [4] ?

eruption (83%) (29%) (21%) (21–
41%)
Pemphigus [2] [2] [1]
Peripheral edema (28%) (13%) [1] [5] [1] [3] • [5] [4] [1] [1] ü
(8%) (83%) (40%) (44%) (75%) (83%) (12%) (14%)
Petechiae • [1]
(<10%)
Photosensitivity [1] [1] [1] [3] [2]
(<10%)
Pigmentation [1] [1] [1] [1] [12] [3] [1] [2] [1] ü
(>10%) (16%) (60%) (21%) (23%) (16%)
Pityriasis rubra [1] [1]

pilaris
Pruritus [7] (14– [1] [1] [9] [4] [8] [5] [3] [4] [22] [3] [9] [8] üü
(24%) 24%) (91%) (11%) (40%) (14%) (21%) (61%) (10%) (30%) (65%) (42%) (91%) (14%)
Psoriasis [4] [1] [3] [22] [4] ?

(>5%)
Purpura [1] (8%) [1] [2] [3] [1] [1] [2] [1] [1] ü
Pustules [1] [1] [1]
Pyoderma [1] [1] [1] [1] [3]

gangrenosum
Radiation recall [1] [2] [1] [1]

dermatitis
Rash [2] [5] [16] [9] [47] [10] [112] [63] [26] [5] [28] [16] [30] [12] üü
(42%) (13– (91%) (67%) (89%) (34%) (80%) (66–85%) (69%) (11%) (83%) (36%) (91%) (58%)
40%)
Rosacea [1] [2] [1] [1] [1]
Sarcoidosis [1] [47] [4] [2] ?

Scleroderma [2] [1]
Sclerosis [1] [1]
Seborrheic [1] [1] [2]

dermatitis
Serum sickness [1] [21] ?

(8%) (<20%)
Skin reactions [1] [1]
Squamous cell [1] [1] [2] [1]

carcinoma (7%)
Stevens-Johnson [1] [1] [13] [3] [5] [5]

syndrome
Sweet’s syndrome [1] [7] [1] [3] [1] [3]
BIOLOGICS CLASS REACTIONS
Telangiectasia [1] [1] [1] [1] [1]
Thrombocytopenic [10] [1] [2] [1]

purpura
Toxic epidermal [2] [2] [1] [1] [3] [1] [3] ü

necrolysis
Toxicity [6] [1] [9] [4] [18] [7] [9] [10] [9] [4] [3] [6] [26] [3] üü
(16%) (38%) (63%) (36%) (84%) (68%) (30– (35%) (75%) (95%) (12%)
44%)
Transient [1] [2]
acantholytic
dermatosis
Tumor lysis [2] [1] [1] [3] [3] ?

syndrome (17%) (<5%) (<5%) (21%)
Tumors [5] [1]

(11%) (11%)
Ulcerations [3] [1] [1] [1] [2] [1] [1] ü
Urticaria [3] [2] [1] [1] [3] [3] [2] [1] [5] ü
(16– (<10%) (8%)
30%)
Vasculitis [1] [1] [1] [4] [1] [1] [2] [7] [1] [4] ü
Vitiligo [3] [9] [3]
Xerosis (15%) [1] [1] [14] [1] [12] [12] [2] [1] [1] [2] [12] ü
(>10%) (16%) (49%) (<10%) (56%) (53%) (<10%) (>10%) (13%) (16%) (62%)
HAIR
Abnormal hair [2] [1]

growth
Alopecia [2] [5] (5%) [3] [10] [6] [2] [16] [3] [3] [1] ü
(10%) (43%) (<10%) (14%) (10– (48%) (19%) (54%)
15%)
Hair changes [3] [4] [2] ?
(20%) (9%)
(18%)
Hirsutism [1] [1]
Hypertrichosis [3] [4] [2] [3]
NAILS
Nail changes [1] [3] [1] [2] ?

(21%) (25%) (17%) (9–
29%)
Nail disorder [2] [1] [1]
Paronychia [1] [15] [11] [13] [13] ?

(14%) (15%) (14–32%) (85%)
Pyogenic granuloma [1] [1] [2] [1]
MUCOSAL
Aphthous stomatitis [1] [1] [1] [1] [2] [1]

(5%)
Epistaxis [5] [1] [1] (15%) [1]
(17%) (17%)
Mucocutaneous [1] [1] [2]
eruption
Mucosal [2] [1] [1] (6%) ?

inflammation (59%) (18%)
Mucositis [11] [2] [10] [1] [10] [4] [2] [1] [4] ü
(75%) (45%) (>10%) (16%) (21%) (6–17%) (15%) (75%)
Oral lichenoid [3] [1]

eruption
Oral mucositis [2] [1] ?

(82%) (33%)
Oral pigmentation [3] [1]
Oral ulceration [1] [2] [1] [1] [1] [1] [3] ü

(18%) (15%)
Oropharyngeal pain [1] [1]
Perianal fistula [1] [1] ?

(67%)
Rectal hemorrhage [1] [1]
Stomatitis [1] [1] [8] [1] [3] [1] [10] [7] [1] [4] [2] ü
(22%) (14%) (75%) (43%) (25%) (26%) (6–17%) (30%) (100%) (69%)
Xerostomia [1] (11%) [1] [1] [4] [1] (7%) ü
(33%) (44%) (41%)
BISPHOSPHONATES CLASS REACTIONS
BISPHOSPHONATES
A E I P R Z =
SKIN
Angioedema [2] • • ü
Candidiasis (6%) (12%)
Eczema [1] [1]

(13%)
Edema • [3]
Exanthems [1] [1]
Hypersensitivity [3] • • [1] ü

(19%)
Peripheral edema [1] (8%) (5–21%) ü
Pruritus [1] [1] [1] • ü
(4–5%)
Rash [5] • [1] [1] [1] [3] üü
(8%) (6%)
syndrome
Toxic epidermal [1] [1]

necrolysis
Urticaria [1] [1]
HAIR
Alopecia [1] [1]

(12%)
MUCOSAL
Stomatitis [1] • (8%) ü
A Alendronate; E Etidronate; I Ibandronate; P Pamidronate; R Risedronate; Z Zoledronate
CLASS REACTIONS CALCIUM CHANNEL BLOCKERS
CALCIUM CHANNEL BLOCKERS

A D F I Nic Nif Nis V =
SKIN
Acneform eruption [1] • [1]
AGEP [21] [3] ?

Anaphylaxis [1] [1]
Angioedema [6] [3] [1] [1] [2] [3] ü

(6%)
Dermatitis (<10%) [1] [1]
Diaphoresis • [2] [1] • [2] • [2] ü

Ecchymoses • • [1]
Eczema [1] [1]
Edema [20] [4] [1] [6] • [3] [1] [1] üü

(5–14%) (<10%) (7%)
Erythema [2] • [2]
Erythema multiforme [2] [11] [5] [4] ü

(31%)
Exanthems [2] [17] [2] [1] [9] [1] [8] ü

(31%)
Exfoliative dermatitis [6] [5] • [2] ü
Facial edema • • •
Hyperkeratosis [1] [2]
Lichenoid eruption [1] [3]
Linear IgA [1] [1]
Lupus erythematosus [5] [3] [2]
Peripheral edema [44] [1] [6] [2] [12] [6] [1] ü

(34%) (5–8%) (22%) (7%) (6%) (22%) (<10%)
Petechiae [1] • •
Photosensitivity [11] [5] [4]
Pigmentation [2] [10] •
Pruritus [3] [6] • [1] [3] • [6] ü

(6%)
Purpura [1] [3] [1] [3] [1] ü

Pustules [2] •
Rash (<10%) [4] • • [3] [2] • [2] üü
A Amlodipine; D Diltiazem; F Felodipine; I Isradipine; Nic Nicardipine; Nif Nifedipine; Nis Nisoldipine; V Verapamil
CALCIUM CHANNEL BLOCKERS CLASS REACTIONS
A D F I Nic Nif Nis V =
Stevens-Johnson [1] [4] [3] [5] ü

syndrome
Telangiectasia [5] [2] [2]
Toxic epidermal [2] [4] [2]

necrolysis
Ulcerations [1] •
Urticaria [1] [5] [1] • [3] [7] • [5] üü

Vasculitis [2] [6] [4] [2] ü
Xerosis • •
HAIR
Alopecia • [2] [4] • [5] ü

NAILS
Nail dystrophy [1] [1] [1]
MUCOSAL
Gingival [30] [10] [5] [1] [2] [75] • [10] üü

hyperplasia/hypertrophy (31%) (74%) (2–10%) (75%) (19%)
Oral ulceration [1] • [1]
Xerostomia [1] [2] [1] • • • • • üü
A Amlodipine; D Diltiazem; F Felodipine; I Isradipine; Nic Nicardipine; Nif Nifedipine; Nis Nisoldipine; V Verapamil
CLASS REACTIONS CEPHALOSPORINS
CEPHALOSPORINS
Cdxl Cclor Ctan Coxm Cnir Cixm Ctxm Czim Caxn Cpm CF Cple =
SKIN
AGEP [2] [2] [1] [1] [4] [1] ü

Anaphylaxis [1] [4] [3] [7] [1] [1] [3] [15] • ü
Angioedema [1] • • • • [3] ü
Candidiasis • • • [3] •
(5%)
Dermatitis [1] [2]
DRESS syndrome [1] [1] [4] [2]
Erythema [1] [1] (9%)
Erythema multiforme • [6] • [1] [2] [1] [1] ü

(13%)
Exanthems [1] [9] [2] • [3] [1] [7] • ü
(6%) (6%)
Fixed eruption [2] [1] [1]
Hypersensitivity [1] [4] [1] [2] [1] [4] [2] [2] [1] ü
Jarisch–Herxheimer [1] [1]
reaction
Lupus erythematosus [1] [2]
Pemphigus [1] [1] [1] [1]
Pemphigus [1] [2]

erythematodes
Pruritus [1] [4] • • • [1] [3] [3] [2] [3] [7] [1] üü
(9%)
Pustules [1] [1]
Rash • [2] [2] [1] • [2] [3] [5] [5] [12] [9] [1] üü
(12%) (51%) (10%)
SDRIFE [1] [1]
Serum sickness • [7]
Serum sickness-like [23] • [2] • [1] [2] ü

reaction
Stevens-Johnson • [1] • • • [1] [1] • [1] [1] ü

syndrome
Toxic epidermal [1] [2] • [1] [1] [1] ü

necrolysis
Urticaria [2] [5] • [2] • [2] • • [4] [1] • ü

(13%)
MUCOSAL
Glossitis [1] [2]
Oral candidiasis [1] [1] •
1st generation: Cdxl Cefadroxil; 2nd generation: Cclor Cefaclor, Ctan Cefotetan, Coxm Cefuroxime; 3rd generation: Cnir Cefdinir, Cixm Cefixime,
Ctxm Cefotaxime, Czim Ceftazidime, Caxn Ceftriaxone; 4th generation: Cpm Cefepime; 5th generation: CF Ceftaroline Fosamil; Cple Ceftobiprole
DMARDS CLASS REACTIONS
DISEASE-MODIFYING ANTIRHEUMATIC DRUGS (DMARDS)

Ab Ad Az Ce Cy E G H I M P R S =
SKIN
Abscess [1] [2] [4] [2]
Acneform eruption [3] [2] [7] [1] [6] [1] ?

(13%) (67%)
AGEP [2] [1] [22] [2] [3] ?
(25%)
Anaphylaxis [1] [1] [8] [2] [1] [10] [9] [7] [4] ü
(<10%)
Angioedema [3] [2] • [1] [1] • [2] [1] [4] [3] ü
(11%) (11%)
Angioma [1] [1]
Atrophy [1] [1]
Basal cell carcinoma [3] [2] [4] [1] [1] [1]
Bullous dermatitis [1] [2] [1] [4] [3] [1]
Bullous pemphigoid [1] [1] [6] [3]
Burning [1] [1]
Candidiasis [1] [2] [4] [1]

(16%) (5%)
Carcinoma [2] [3] [2] [2]
Cellulitis [1] [2] [2] [5] [1] [1]

(<5%)
Churg-Strauss syndrome [1] [1]
Cicatricial pemphigoid [1] [2]
Cyst [5] [1]
Dermatitis [1] [4] • [3] [1] [4] [2] [4] [2] [2] ü
Dermatomyositis [5] [4] [1] [14]
Diaphoresis [2] [1]

(15%)
DRESS syndrome [2] [31] ?
(7%)
Ecchymoses [1] [1] [1]
Eccrine squamous [1] [1]

syringometaplasia
Eczema [2] [2] [5] [1] ?

(15%) (19–
30%)
Edema [1] [3] [2] [1] [1]
(5–
14%)
Erysipelas [1] (<5%)
Ab Abatacept; Ad Adalimumab; Az Azathioprine; Ce Certolizumab; Cy Cyclosporine; E Etanercept; G Golimumab; H Hydroxychloroquine;

I Infliximab; M Methotrexate; P Penicillamine; R Rituximab; S Sulfasalazine
CLASS REACTIONS DMARDS
Erythema [1] [1] [1] [1] [1] [2]

(7%) (16%)
Erythema annulare [3] [1]
centrifugum
Erythema multiforme [1] [2] [2] [2] [4] (<5%) [8] ü

Erythema nodosum [1] [4] [1] [1] [1] [1] [2] ü
Erythroderma [3] [2] [1]
Exanthems [10] [1] [2] [4] [4] [5] [8] [1] [23] ü
(5%) (<5%) (15%) (23%)
Exfoliative dermatitis [1] [3] [5]
Facial edema [1] [1] [1] [1] [1] [1] [1] ü

Fixed eruption [1] [1] [1] • [1] [7]
Folliculitis [8] [1] [2] [2]
Fungal dermatitis [1] [1] ?

(42%)
Furunculosis [1] [1] [1]
Granulomas [1] [2] [1]
Granulomatous reaction [5] [5] [1] [1]
Hand–foot syndrome [2] [3] ?

(31%)
Henoch–Schönlein [2] [3] [1]
purpura
Herpes [1] [1] [2]
Herpes simplex [3] [1] [3] [4] [1] [4] [2] [2] ü
(>5%) (35%) (10%)
Herpes zoster [3] [10] [8] [3] [2] [5] [11] [7] [7] ü
(27%)
Hidradenitis [2] [1] [2] [1] [1]
Hyperkeratosis [1] [1]
Hypersensitivity [2] [3] [28] • [2] [1] [11] [4] [3] [5] [21] ü
(11%) (9%)
Kaposi’s sarcoma [1] [14] [5] [1] [3]
Keratoacanthoma [1] [1] [1]
Leprosy [1] [2] [1]
Lesions [2] [1]
Leukocytoclastic [1] [1] [2]

vasculitis
Lichen planus [2] [1] [2] [4] [3]
Lichenoid eruption [5] [1] [1] [3] [4] [3] [7] ü

Linear IgA [2] [1]

Lupus erythematosus [16] [1] [25] [3] [35] [43] [1] [34] ü
(59%)
Lupus syndrome [3] [1] [3] [11] [1] [1]
Lymphadenopathy [1] [1] [1]
Lymphoma [8] [1] [12] [3] [1] [9] [5] [1] ü

Lymphomatoid papulosis [1] [1]
Lymphoproliferative [4] [2] [1] [1] [1] [1]

disease
Malignancies [10] [4] [1] [2] [3] [5] [2] [1] ü

(23%) (8%)
Melanoma [6] [1] [2] [1] [1] [1]
Molluscum contagiosum [1] [2] [2]
Morphea [1] [1] [2]
Necrosis [6] [1] [1]
Necrotizing fasciitis [1] [1] [1] [1]
Neoplasms [2] [2] [2] [1] [2] [2] [2] [1] ü

Neutrophilic dermatosis [1] [1] [4] ?
(76%)
Nevi [3] [1] [2]
Nodular eruption [1] [3] [15]
Non-Hodgkin’s [1] [1] [2]

lymphoma
Palmar–plantar [3] [1]

pustulosis
Pemphigus [1] [75] [1] ?

Pemphigus foliaceus [1] [16]
Peripheral edema [1] (<5%) [3] [1] [1] (<10%) [1] ü

(10%) (14%)
Photoallergic reaction [1] [1]
Photosensitivity [1] [6] [9] [4]

(5%) (10%)
Phototoxicity [3] [1]
Pigmentation [1] [19] (<10%) [3] ?

(37%) (<10%)
Pityriasis lichenoides [1] [1] [2]
chronica
Porokeratosis [4] [1] [1]
Pruritus • [6] [1] [1] [2] [2] [13] [8] [1] [2] [8] [8] ü
(12%) (14%) (47%) (20%) (<5%) (44– (14%) (10%)
50%)
Pseudolymphoma [1] [6] [1] [2] [10] [2]

CLASS REACTIONS DMARDS
Psoriasis [13] [39] [6] [2] [19] [2] [13] [56] [4] [4] [1] ü
(19%)
Purpura [4] [5] [1] [1]
Pustules [1] [2] [1] [5] [2]
Pyoderma gangrenosum [1] [1] [1] [1] [3]
Rash [6] [4] [10] [2] [1] [7] [3] [4] [13] [11] [6] [12] [19] üü
(23%) (12%) (<10%) (5%) (7– (15%) (<10%) (25%) (5%) (44– (58%) (>10%)
12%) 50%)
Raynaud’s phenomenon [2] [1] [3]
Rosacea [1] [1] [1]
Sarcoidosis [8] [10] [5] [1] [2] [1]
Scabies [5] [1] [1]
Scleroderma [1] [1] [7]
Serum sickness • [2] [21] [1] ?

(<20%)
Serum sickness-like • [5] [1] [5]
reaction (<17%)
Skin cancer [1] [1]
Squamous cell carcinoma [5] [5] [11] [12] [4] [1] [1] [2] ü
Stevens-Johnson [2] [1] [1] [1] [4] [5] [9] ü
syndrome
Striae [1] [1]

(9%)
Sweet’s syndrome [12] [1] [1]
Thrombocytopenic [1] [5] [2]

purpura
Tinea [1] [3]
Toxic epidermal [1] [1] [3] [2] [8] [2] [3] [13] ü
necrolysis (<10%)
Toxicity [1] [3] [1] [2] [1] [1] [2] [9] [3] ü
(6%) (75%) (10%) (12%)
Tumors [1] [8] [1] [1] [1]
(14%) (11%)
Ulcerations [1] • [1] [12]
Urticaria [1] [3] [5] • [2] [2] [2] [6] [4] [2] [5] [11] ü
(17%) (44– (8%) (<5%)
50%)
Vasculitis [2] [9] [5] • [3] [23] [1] [1] [18] [9] [7] [4] [4] üü
(13%) (25%) (63%) (>10%)
Vesiculation [1] [1] [1]
Vitiligo [2] [1] [4]

Xerosis [1] [1] [1]
HAIR
Alopecia [5] [9] [1] [2] [5] [2] [6] [25] [3] [1] [6] ü
(54%) (20%) (10%)
Alopecia areata [7] [6] [1] [1] [3]
Follicular mucinosis [1] [1]

(<10%)
Hirsutism [10] [2]
NAILS
Discoloration [1] [1]
Leukonychia (Mees’ [2] [1] [1]

lines)
Nail pigmentation [3] [2] [4]
Onychocryptosis [1] [1] [1]
Onycholysis [1] [1]
Onychomycosis [2] [1] [1] ?

(5%) (33%)
Pyogenic granuloma [1] [1]
MUCOSAL
Aphthous stomatitis • • [2] [2] [2] [1]

(9%)
Cheilitis [1] [1] [1]
(10%)
Gingival [157] [1] ?
hyperplasia/hypertrophy (86%)
Gingivitis • [1] (>10%) [1]

(7%)
Glossitis [1] (10%) [1]
Mucocutaneous [1] [2] [1] [2] [2]

reactions (6%)
Mucosal ulceration [1] [1]
Oral candidiasis [1] [1] [1]

(11%)
Oral mucositis [1] [1] [6]
Oral ulceration [2] [2] [1] [11] [5] [3] ?

(61%)
Oropharyngeal pain [1] [1]
(9%)
Stomatitis [3] [1] (5–7%) [2] [18] [6] [2] [1] ü
(24%) (43%) (69%) (<10%)

CLASS REACTIONS DPP-4 INHIBITORS
DPP-4 INHIBITORS
Alog Lina Saxa Sita =
SKIN
Anaphylaxis [1] [1] ü

Angioedema [1] [1] [3] ü
Edema [1] [3] ü
Hypersensitivity [2] [1] [1] ü
Peripheral edema [1] [1] • ü
(10%)
Pruritus [2] [1] [1] ü
Rash [1] [1] [2] ü
Stevens-Johnson [1] [1] ü
syndrome
Alog Alogliptin; Lina Linagliptin; Saxa Saxagliptin; Sita Sitagliptin
EGFR INHIBITORS CLASS REACTIONS
EGFR INHIBITORS
C E G L Nec Nil P Sor Sun =
SKIN
Acneform eruption [62] [27] [32] [4] [1] [1] [18] [6] [1] üü
(97%) (73–80%) (66–85%) (90%) (23–43%) (<10%) (81%) (<10%) (<10%)
AGEP [1] [1] [2]
Anaphylaxis [5] [1] [1] [1] ?

(13%) (30%)
Angioedema [1] [1]

(7%)
Dermatitis [4] [4] (<10%) ?
(80%) (30%)
Desquamation [3] [1] [2] [3] [9] ü
(89%) (39%) (13%) (50%)
Eczema [1] [1] [1] (<10%) [2] [2] ü

Edema [1] [1] [3] [1] [3] [6] ü
(29%) (15%) (11%) (32%)
Erythema [3] (18%) [1] [1] [2] [5] [4] [6] ü
(14%) (<10%) (65%) (19%) (7%)
Erythema multiforme [1] [11]
(17%)
Exanthems [5] [3] [3] [2] [2] [3] ü
(8%) (21%)
Exfoliative dermatitis [1] [1] [1] [2] [1] [1] ü
(14%) (25%) (<10%) (10%)
Facial edema [1] • [1] [3] ?
(24%)
Fissures [4] [1] [1] [4] ?
(14%) (22%) (21%)
Folliculitis [13] [9] [4] [1] (<10%) [3] [3] ü
(83%) (11%)
Hand–foot syndrome [5] [3] [2] [9] [3] [113] [68] ü
(6%) (30–60%) (76%) (23%) (89%) (45–65%)
Hematoma [1] (<10%)
Hypersensitivity [8] [1] [2]
Jaundice [1] • [1] [1] ?

(35%)
Keratosis pilaris [1] [1] [2]
Necrosis [1] [1]
Nevi [1] [3] [2]
Papulopustular [7] [9] [3] [4] ?

eruption (83%) (29%) (21%) (21–41%)
C Cetuximab; E Erlotinib; G Gefitinib; L Lapatinib; Nec Necitumumab; Nil Nilotinib; P Panitumumab; Sor Sorafenib; Sun Sunitinib
CLASS REACTIONS EGFR INHIBITORS
Peripheral edema [1] • [1] [1] [1] ü

(40%) (44%) (12%) (17%)
Pigmentation [1] [1] [1] [2] [14] ü
(18%) (38%)
Pruritus [9] [8] [5] [3] [2] [13] [9] [10] [3] üü
(40%) (21%) (61%) (33%) (60%) (21%) (91%) (21%) (<10%)
Psoriasis [1] [1] [1] [2]
Purpura [3] [1]
Pustules [1] [1] [1]
Pyoderma [1] [8]

gangrenosum
Radiation recall [2] [1] [3] [1]

dermatitis
Rash [47] [112] [63] [25] [9] [16] [30] [51] [17] üü
(89%) (80%) (66–85%) (55%) (76–81%) (56%) (91%) (30–75%) (14–38%)
Rosacea [1] [2] [1]
Seborrheic dermatitis [1] [2] [1]
Squamous cell [1] [1] [8]

carcinoma

syndrome
Telangiectasia [1] [1] [1]

necrolysis
Toxicity [18] [9] [10] [6] [2] [7] [26] [16] [24] üü
(63%) (84%) (68%) (46%) (8%) (95%) (75%) (67%)
Ulcerations [1] [2] [1]
Urticaria [1] (<10%) •
Vasculitis [1] [1] [1]
Xerosis [14] [12] [12] [1] [2] [2] [12] [6] [3] üü
(49%) (56%) (53%) (29%) (67%) (13–17%) (62%) (14%) (17%)
HAIR
Alopecia (5%) [10] [6] [2] [4] [3] [26] [5] ü

(14%) (33%) (<10%) (54%) (67%) (5–12%)
Hair changes [3] [4] [2] [1] ?
(20%) (9%) (26%)
Hair pigmentation [2] [8] ?
(38%)
Hypertrichosis [3] [4] [2]
NAILS
Nail changes [1] [3] [1] [2] ?

(21%) (25%) (17%) (9–29%)
EGFR INHIBITORS CLASS REACTIONS
Nail disorder [2] [1] [1]

(10%) (<10%)
Paronychia [15] [11] [13] [3] [13] ü
(14%) (15%) (14–32%) (27%) (85%)
Pyogenic granuloma [1] [1] [2] [1]
Splinter hemorrhage [4] [2] ?

(70%)
Subungual hemorrhage [2] [4]
MUCOSAL
Aphthous stomatitis [1] [1] [1]
Cheilitis [1] [1]

(14%)
Epistaxis [1] [1] [2] [2]
(11%) (13%)
Glossodynia (<10%) [1]
(15%)
Mucosal inflammation [1] [1] (6%) [4] ?
(18%) (15%) (54%)
Mucositis [10] [10] [4] [2] [4] [12] [18] ü
(21%) (6–17%) (11–35%) (75%) (28%) (~60%)
Oral mucositis [2] [1] [1] ?
(82%) (33%) (20%)
Oral ulceration [1] [1] [1] • [1] ü
(5%)
Oropharyngeal pain • [1]
(10%)
Stomatitis [3] [10] [7] [1] (11%) • [4] [13] [17] üü
(25%) (26%) (6–17%) (41%) (100%) (28%) (60%)
Xerostomia (11%) [1] [1] [2] ?
(11%) (<10%) (~60%)
CLASS REACTIONS FLUOROQUINOLONES
FLUOROQUINOLONES
B C L M N =
SKIN
AGEP [4] [1] [2] ü

Anaphylaxis [15] [6] [5] ü
Angioedema [8] [1]
Bullous dermatitis [1] [2] [1] ü

Candidiasis [2] • • ü
Diaphoresis [5] [1] • • ü
Edema • [1]
Erythema [2] [1]
Exanthems [4] [2] [2] ü

Hypersensitivity [1] [5] [5] [6] ü

Peripheral edema [1] [1]
Photosensitivity [19] [3] [5] [1] ü

Phototoxicity [5] [5] [4] ü
Pigmentation [1] [1]
Pruritus [11] [3] [3] [1] ü

Purpura [4] [2]
Radiation recall [1] [2]

dermatitis
Rash [13] [2] [4] • ü

(<10%)
Stevens-Johnson [9] [2] [1] ü
syndrome
Thrombocytopenic [1] [2]

purpura
Toxic epidermal [11] [5] [2] [2] ü

necrolysis
Toxicity [3] [1]
Urticaria [9] [1] [3] [1] ü

Vasculitis [11] [3]
Xerosis [1] [1] • ü
B Besifloxacin; C Ciprofloxacin; L Levofloxacin; M Moxifloxacin; N Norfloxacin
FLUOROQUINOLONES CLASS REACTIONS
B C L M N =
MUCOSAL
Stomatitis [4] [1]
Xerostomia [3] [1] [1] • ü
B Besifloxacin; C Ciprofloxacin; L Levofloxacin; M Moxifloxacin; N Norfloxacin
CLASS REACTIONS NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)

A C D E F Ib In Ktp Ktl Mx Np O P S =
SKIN
AGEP [1] [7] [1] [5] [1] [2] ?

(50%)
Anaphylaxis [8] [8] [16] [1] [5] • [4] [3] [1] [2] • • [4] ü
(<10%) (48%) (25%)
Angioedema [32] [9] [2] [1] [1] [8] [2] [1] [1] [3] [5] • [3] • üü
(22%)
Bullous dermatitis [4] [1] [2] [3] [2] [1] • [5] [1] ü
(29%)
Bullous pemphigoid [1] [1] [1] [2]
Churg-Strauss [1] [1]

syndrome
Dermatitis [2] [10] [1] [5] [5] [29] • [5] [1] ü

(14%)
Dermatitis [1] [2] [1] [1] [2]
herpetiformis
Diaphoresis • • [1] • [1] [2] [3] • [1] ü

(<10%)
DRESS syndrome [1] [1] [1] [4] [4] [1]
Ecchymoses [1] • • [1] (3–9%) • • • ü

Eczema • • [1] [1] [3] [1]
Edema [5] (3–9%) [1] [1] (<10%) [1] [1] • • ü

(6%) (6%) (6%) (<9%)
Embolia cutis [16] [2] [1] [1]
medicamentosa
(Nicolau syndrome)
Erythema [2] [4] [4] [1] [2] [1] [1] [1] ü

(14%) (21%)
Erythema multiforme [9] [3] [6] • • [11] [1] [1] [1] [2] [1] [12] [8] ü
(13%)
Erythema nodosum [9] • [1] [1] [1]
(<5%)
Exanthems [11] [7] [6] [2] [3] [9] [7] [3] [1] [1] [9] [1] [8] [9] üü
(18%) (49%) (<5%) (11%) (14%) (>5%) (<5%)
Excoriations [1] [1]
(6%)
Exfoliative dermatitis [1] [1] [1] • [1] [1] • • • [1] • ü
Facial edema [1] [1] [2] • [1]
Fixed eruption [22] [2] [4] [2] [2] [15] [2] [1] [25] [15] [5] ü
(18%) (24%)
A Aspirin; C Celecoxib; D Diclofenac; E Etodolac; F Flurbiprofen; Ib Ibuprofen; In Indomethacin; Ktp Ketoprofen; Ktl Ketorolac; Mx Meloxicam;
Np Naproxen; O Oxaprozin; P Piroxicam; S Sulindac
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) CLASS REACTIONS
Hematoma [1] [2] [3]
Henoch–Schönlein [1] [1]

purpura
Herpes simplex [1] • [1]
Herpes zoster • [1]
Hot flashes • • • • • • [1] • • ü

Hypersensitivity [5] [8] [5] [4] [5] [1] [2] [2] [2] [1] • ü
(5%)
Jaundice [1] [1] • [1]
Lichen planus [1] [3] [1]
Linear IgA [6] [1] [1] [1] [3]
Lupus erythematosus [1] [5] [2] [1]
Pemphigus [1] [1] [1] [1] [3]
Peripheral edema [1] [2] [1] [1] [2] • [1] [1] [1] ü
(5%)
Petechiae • •
Photoallergic reaction [1] [1] [2]
Photosensitivity • [4] [1] • [6] [1] [35] • • [16] • [40] [2] ü

(11%)
Pruritus [6] [6] [6] [7] [1] [5] [3] [4] [1] [3] [5] (<10%) [6] [5] üü
(>5%) (<10%) (<10%) (<5%) (<5%) (<10%) (<10%) (<10%) (17%) (<10%) (<10%)
Pseudolymphoma [1] [1] [1] [1] [1] [1] [1] [1] ü

Psoriasis [3] [1] [2] [7] [1] [1]
Purpura [8] [1] [2] [1] [5] [1] [1] • [4] [2] [2] ü
(<10%)
Purpura fulminans [2] [1]
Pustules [1] [2]
Rash (<10%) [11] [4] [5] • [2] [1] [1] [1] [3] [2] [2] [1] (>10%) üü
(40%) (>10%) (>10%) (>10%) (>10%) (<10%) (3–9%) (>10%)
SDRIFE [1] [1] [1]
Serum sickness • • [1]
Serum sickness-like [1] [1] [1]

reaction
Stevens-Johnson [6] [2] [5] • • [10] • • • [1] [1] [2] [2] [5] üü
syndrome (17%)
Toxic epidermal [9] [5] [4] • [1] [8] [6] [1] • [1] [5] [4] [12] [13] üü
necrolysis (6%)
CLASS REACTIONS NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)
Urticaria [72] [11] [7] • • [10] [7] [6] [1] [4] [6] • [7] [4] üü
(83%) (>10%) (<5%)
Vasculitis [2] [4] [3] [2] [1] [8] [5] [1] • [9] [3] • ü
Vesiculobullous [2] [1]
eruption
Wound complications [1] [1]
Xerosis • [3] [1] [1]
HAIR
Alopecia [1] [3] • • [2] • [1] • • [3] [3] • ü

NAILS
Nail changes • • [1]
Onycholysis [1] [1]
MUCOSAL
Aphthous stomatitis [3] [1] [1] [1] [4]
Epistaxis [1] • [1]
Glossitis • •
Oral lesions [1] [2] [1]

(7%)
Oral lichenoid [2] [1] [1] [1]
eruption
Oral mucosal [3] [2]

eruption
Oral mucosal fixed [1] [1]

eruption
Oral ulceration [4] [1] [1] [4] [1] [1]
Rectal hemorrhage • [1]
Rectal mucosal [1] [1]

ulceration
Stomatitis [4] • • (<10%) • • • [2] ü

(8%)
Tongue edema [1] [1] •
Ulcerative stomatitis [1] •
Xerostomia • [2] • • [1] [2] • [2] [1] [2] ü

(26%)
PROTON PUMP INHIBITORS (PPI) CLASS REACTIONS
PROTON PUMP INHIBITORS (PPI)

D E L O P R =
SKIN
Acneform eruption • • • • ü
AGEP [1] [2]
Anaphylaxis • [1] [6] [7] [7] ü

Angioedema • [5] • ü
Candidiasis • •
Dermatitis • • [1] [1] • ü

Diaphoresis • [1] [1] [1] • ü
Ecchymoses • •
Eczema [1] [2] [1] ü

(9%)
Edema • [1] [2] • ü
(<10%)
Erythema • [1]
Erythema multiforme [2] [1] • ü

Exanthems • [1] • ü
Exfoliative dermatitis [1] [1] [3] ü
Facial edema [2] [1] [1] • ü
Fungal dermatitis • •
Herpes zoster • • •
Hypersensitivity [3] [2] [1] [1] ü

Lichenoid eruption [1] [2] [1] ü
Lupus erythematosus [2] [3] [5] [3] ü
Peripheral edema • [2] [2] [2] • ü
Photosensitivity [1] [1] • ü
Pigmentation [1] •
Pruritus • • [1] [8] [1] [2] üü

(3–10%) (<10%)
Pruritus ani et vulvae • [1]
Psoriasis [1] •
Rash • [1] (3–10%) [6] [3] [2] üü

(9%)
Stevens-Johnson [1] • • ü
syndrome
D Dexlansoprazole; E Esomeprazole; L Lansoprazole; O Omeprazole; P Pantoprazole; R Rabeprazole
CLASS REACTIONS PROTON PUMP INHIBITORS (PPI)
D E L O P R =
Toxic epidermal [4] [5] • ü

necrolysis
Urticaria • [1] [3] [9] [2] • üü

(<10%)
Vasculitis [2] [1]
Xerosis [1] [2] • • ü

HAIR
Alopecia [1] [2] • • ü

MUCOSAL
Gingivitis • •
Glossitis [1] • • ü
Oral candidiasis • [3] • ü
Stomatitis [2] [1] • • ü
Tongue edema • [1]
Xerostomia • • [2] • • ü
(<10%)
D Dexlansoprazole; E Esomeprazole; L Lansoprazole; O Omeprazole; P Pantoprazole; R Rabeprazole
STATINS CLASS REACTIONS
STATINS
A F L Pi Pr R S =
SKIN
Acneform eruption • [1] ?

(36%)
Dermatomyositis [4] [1] [1] [2] [5] ü
Diaphoresis • [1]
Ecchymoses • •
Eczema • [2] [4]

(5%)
Edema • [1] • [1] ü
(6%)
Eosinophilic fasciitis [1] [2]
Exanthems [3] [1]

(5%)
Herpes zoster [1] [1] [1] [1] [1] [1] ü
Hypersensitivity [1] • [1]
Jaundice [2] [1]
Lichenoid eruption [1] [1] [2] [1] ü

Lupus erythematosus [2] [2] [4] [1] [5] ü
Peripheral edema • [2] ?
(50%)
Petechiae • [1]
Photosensitivity • [1] [7]
Pruritus [1] [2] [2] • [3] ü

(5%)
Purpura [1] [1] [3]
Radiation recall [1] [1]

dermatitis
Rash [2] • [3] • [7] • [4] üü

(5%) (5–7%) (<10%)
Urticaria [1] • [1]
Vasculitis [1] [2]
HAIR
Alopecia [1] •
MUCOSAL
Cheilitis • [1]
Stomatitis • [2] ?
(64%)
A Atorvastatin; F Fluvastatin; L Lovastatin; Pi Pitavastatin; Pr Pravastatin; R Rosuvastatin; S Simvastatin
CLASS REACTIONS TNF INHIBITORS
TNF INHIBITORS
A C E G I =
SKIN
Abscess [1] [2] [4] ü

Acneform eruption [3] [1] [6] ü
AGEP [1] [2]
Anaphylaxis [1] [2] [10] ü

Angioedema [3] • [1] [2] ü
(11%)
Basal cell carcinoma [1] [1]
Candidiasis [1] [4]

(5%)
Carcinoma [2] [2]
Cellulitis [2] [2] [5] ü

(<5%)
Dermatitis [1] • [3] [4] ü
Eczema [2] [5] ?

(19–30%)
Erythema [1] [1]
Exanthems [2] [4]
Fixed eruption [1] [1] [1] ü

Folliculitis [1] [2]
Granulomas [1] [2] [1] ü

Granulomatous [5] [5] [1] ü
reaction
Henoch–Schönlein [2] [3] [1] ü

purpura
Herpes [1] [2]
Herpes simplex [1] [1] [4] ü

(10%)
Herpes zoster [10] [3] [5] [11] ü
Hidradenitis [2] [2] [1] ü
Hypersensitivity [3] • [1] [11] ü
(11%)
Kaposi’s sarcoma [1] [1]
A Adalimumab; C Certolizumab; E Etanercept; G Golimumab; I Infliximab
TNF INHIBITORS CLASS REACTIONS
A C E G I =
Leprosy [1] [2] [1] ü

Lesions [2] [1]
Leukocytoclastic [1] [1] [2] ü

vasculitis
Lichenoid eruption [5] [3] [3] ü

Lupus erythematosus [16] [25] [3] [35] ü
(59%)
Lupus syndrome [3] [1] [3] [11] ü
Lymphadenopathy [1] [1]
Lymphoma [8] [3] [1] [9] ü

Lymphoproliferative [1] [1]
disease
Malignancies [4] [3] [5] [2] ü

Melanoma [6] [2] [1] [1] ü
Molluscum [1] [2]
contagiosum
Morphea [1] [1]
Necrotizing fasciitis [1] [1]
Neoplasms [2] [2] [2] [2] ü

Nevi [1] [2]
Peripheral edema (<5%) [1] [1] ü

Pityriasis lichenoides [1] [1] [2] ü
chronica
Pruritus [6] [1] [2] [8] ü

(14%) (20%)
Pseudolymphoma [1] [1] [2] ü
Psoriasis [39] [6] [19] [2] [56] üü
(19%)
Pustules [1] [2] [5] ü
Pyoderma [1] [1] [1] ü
gangrenosum
Rash [4] [2] [7] [3] [13] üü

(12%) (5%) (15%) (25%)
Rosacea [1] [1] [1] ü
Sarcoidosis [8] [10] [5] ü
Serum sickness • [2]
Skin cancer [1] [1]
Squamous cell [5] [4] [1] [1] ü

carcinoma
CLASS REACTIONS TNF INHIBITORS
A C E G I =

syndrome
Toxicity [1] [1] [1] [2] ü

(75%)
Tumors [1] [1]
Urticaria [3] • [2] [6] ü

(17%)
Vasculitis [9] • [23] [1] [18] üü
(13%) (25%) (63%)
Vitiligo [2] [4]
HAIR
Alopecia [5] [1] [5] [6] ü

(20%)
Alopecia areata [7] [1] [1] [3] ü
Follicular mucinosis [1] [1]
TYROSINE-KINASE INHIBITORS CLASS REACTIONS
TYROSINE-KINASE INHIBITORS
Aft Axt Cbo Crz Dsa Erl Gft Imt Lpt Lnv Nlo Nnt Srf Snt Vnd =
SKIN
Acneform eruption [25] [2] [27] [32] [2] [4] [1] [6] [1] [4] ü
(92%) (<10%) (73– (66– (90%) (<10%) (<10%) (<10%) (35%)
80%) 85%)
AGEP [1] [1] [7] [2]
Anaphylaxis [1] [1]

(30%)
Bullous dermatitis • [1] [1]
(7%)
Cyst [1] [1]
Dermatitis [1] [1] [4] (<10%) [1] ?

(21%) (<10%) (30%)
Desquamation [1] [2] [9] ?
(39%) (50%)
Diaphoresis (13%) [1]
(6%)
DRESS syndrome [2] [3] [1]
Eczema (<10%) [1] [1] (<10%) [2]
Edema [11] [6] [1] [35] [1] [3] [3] [6] ü

(23– (38%) (80%) (29%) (11%) (32%)
55%)
Erythema [1] (11%) [2] (18%) [1] [5] [1] [2] [4] [6] ü
(<10%) (<10%) (19%) (7%)
Erythema [1] [2] [1] [11] [1]
multiforme (17%)
Erythema nodosum • [1]
Exanthems [3] [3] [9] [1] (21%) [2] [3] ?

(8%) (21%)
Exfoliative • [1] [1] [4] [1] [1] [1] [1] ü
dermatitis (14%) (<10%) (10%)
Facial edema [1] [3] • [1] [3] ?

(<10%) (24%)
Fissures [2] [1]
(12%)
Folliculitis [1] [9] [4] [1] [1] (<10%) [3] [5] ü
(11%) (49%)
Graft-versus-host [1] [1]
reaction
Hand–foot [2] [15] [17] [1] [3] [2] [3] [9] [2] [2] [113] [68] [4] ü
syndrome (10%) (64%) (50%) (30– (76%) (47%) (89%) (45– (36%)
60%) 65%)
Herpes (<10%) •
Hyperhidrosis [1] [1] (<10%) [1]

(<10%) (12%)
Aft Afatinib; Axt Axitinib; Cbo Cabozantinib; Crz Crizotinib; Dsa Dasatinib; Erl Erlotinib; Gft Gefitinib; Imt Imatinib; Lpt Lapatinib; Lnv Lenvatinib;
Nlo Nilotinib; Nnt Nintedanib; Srf Sorafenib; Snt Sunitinib; Vnd Vandetanib
CLASS REACTIONS TYROSINE-KINASE INHIBITORS
Hyperkeratosis (7%) (7%) [4]
Hypersensitivity • [2]
Hypomelanosis [5] [1]
Jaundice (25%) [1] • [1] [1] ?

(35%)
Keratosis pilaris [1] [1] [2]
Lesions [1] [2] ?

(38%)
vasculitis
Necrolysis [1] [1]
Necrosis [1] [1]
Nevi [1] [3] [2]
Palmar–plantar [1] [1]

hyperkeratosis
Panniculitis [4] [3]
Papulopustular [9] [3] [1] ?

eruption (29%) (21%)
Peripheral edema [6] [3] • [5] [3] [1] [1] ?

(28%) (44%) (75%) (37%) (44%) (17%)
Photosensitivity [2] [1] [1] [3] [8] ?
(<10%) (23%)
Pigmentation [1] [1] [12] [1] [2] [14] [6] ü

(60%) (18%) (38%)
Pityriasis rubra [1] [1]
pilaris
Pruritus [2] [1] [4] [8] [5] [3] [3] [13] [1] [10] [3] [2] ü
(13%) (8%) (14%) (21%) (61%) (10%) (33%) (21%) (19%) (21%) (<10%) (11%)
Psoriasis [3] [1] [1] [2]
Purpura [3] [1] [1]
Pyoderma [1] [1] [8]

gangrenosum
Radiation recall [1] [3] [1]

dermatitis
Rash [49] [3] [1] [4] [10] [112] [63] [26] [25] [1] [16] [4] [51] [17] [34] üü
(92%) (14%) (30%) (16%) (34%) (80%) (66– (69%) (55%) (23%) (56%) (41%) (30– (14– (67%)
85%) 75%) 38%)
Rosacea [2] [1] [1]
Seborrheic [1] [2] [1]

dermatitis
TYROSINE-KINASE INHIBITORS CLASS REACTIONS
Squamous cell [1] [2] [1] [8]

carcinoma
Stevens-Johnson [1] [13] [2] [2]

syndrome
Sweet’s syndrome [1] [3] [3]
Telangiectasia [1] [1]

necrolysis
Toxicity [3] [2] [7] [9] [10] [9] [6] [2] [7] [16] [24] [9] ü
(36%) (84%) (68%) (30– (46%) (75%) (67%) (48–
44%) 50%)
Ulcerations [1] [2] [1]
Urticaria [1] [1] [3] (<10%) •

(<10%)
Vasculitis [1] [1] [2] [1]
Wound [1] [1] [1]

complications
Xerosis [6] (10%) [1] [1] [12] [12] [2] [1] [1] [2] [6] [3] [3] ü
(15%) (23%) (<10%) (56%) (53%) (<10%) (29%) (20%) (13– (14%) (17%) (15%)
17%)
HAIR
Alopecia [1] [2] (16%) [1] [3] [10] [6] [2] [2] (12%) [4] [2] [26] [5] [1] üü
(7%) (6%) (7%) (<10%) (14%) (10– (33%) (<10%) (71%) (67%) (5–
15%) 12%)
Hair changes (34%) [4] [1] [2] ?
(20%) (26%)
Hair pigmentation [2] [2] [2] [8] ?
(34%) (38%)
Hypertrichosis [4] [2]
NAILS
Nail changes [2] [3] [1] ?

(16%) (25%) (17%)
Nail disorder [1] [1] [1] [1]
(10%) (<10%)
Paronychia [10] [11] [13] [3] [5] ?

(33– (15%) (14– (27%) (7%)
85%) 32%)
Pyogenic [1] [2]
granuloma
Splinter [4] [2] [2] ?

hemorrhage (70%)
Subungual [2] [4]

hemorrhage
CLASS REACTIONS TYROSINE-KINASE INHIBITORS
MUCOSAL
Aphthous • [1] [1] (41%) [1] ?

stomatitis
Cheilitis [1] [1] [1] [1]

(7%) (14%)
Epistaxis [3] [1] [1] [1] [2] [2] [2] ?
(17%) (8%) (24%) (11%) (13%)
Glossodynia [1] (25%) (<10%) [1] ?
(15%)
Mucocutaneous [1] [1] [1]
eruption
Mucosal [7] [2] [2] [1] [1] [1] [4] [1] ü

inflammation (69%) (15%) (23%) (18%) (15%) (50%) (54%) (27%)
Mucositis [10] [1] [1] [1] [10] [4] [2] [2] [12] [18] [2] ü
(50– (30%) (16%) (21%) (6– (15%) (11– (28%) (~60%) (14%)
90%) 17%) 35%)
Oral mucositis [1] [1] [1] ?
(33%) (20%)
Oral ulceration [1] [1] [3] (41%) • [1]
(15%) (5%)
Oropharyngeal pain [1] (25%) [1] ?
(10%)
Rhinorrhea (11%) •
Stomatitis [19] [1] (51%) [1] [1] [10] [7] [1] [3] • [1] [13] [17] [2] ü
(50– (15%) (11%) (26%) (6– (41%) (47%) (28%) (60%) (33%)
90%) 17%)
Xerostomia [1] [1] [1] (17%) [1] [1] [2] ?
(20%) (33%) (44%) (11%) (<10%) (~60%)
CONCORDANCE OF SYNONYMS AND TRADE NAMES WITH GENERIC NAMES
Synonym/Trade name Generic Synonym/Trade name Generic

13-cis-retinoic acid isotretinoin Acnamino minocycline
3,4-methylenedioxymethamphetamine MDMA Acnavit tretinoin
3TC lamivudine Acon vitamin A
4-aminopyridine dalfampridine Act-3 ibuprofen
4-demethoxydaunorubicin idarubicin ACT dactinomycin
4-DMDR idarubicin Acta tretinoin
5-aminosalicylic acid mesalamine Actacode codeine
5-ASA mesalamine Actemra tocilizumab
5-aza-2’-deoxycytidine decitabine ActHIB Hemophilus B vaccine
5-fluorouracil fluorouracil Actigall ursodiol
6-mercaptopurine mercaptopurine Actilyse alteplase
6-MP mercaptopurine Actimmune interferon gamma
actinomycin-D dactinomycin
A Actiprofen
Actiq
ibuprofen
fentanyl
A-Acido tretinoin
A-Gram amoxicillin Activacin alteplase
Abaprim trimethoprim Activase alteplase
Abbocillin penicillin V Actonel risedronate
Abelcet amphotericin B Actos pioglitazone
Aberal tretinoin Acuitel quinapril
Aberela tretinoin Acular ketorolac
Abetol labetalol Acupril quinapril
Abilify aripiprazole ACV acyclovir
Abilitat aripiprazole Acyclo-V acyclovir
Abraxane paclitaxel acycloguanosine acyclovir
Abrifam rifampin Acyvir acyclovir
Abstral fentanyl Aczone dapsone
Ac-De dactinomycin Adalat nifedipine
Acaren vitamin A Adalate nifedipine
Accolate zafirlukast Adant hyaluronic acid
AccuNeb albuterol Adapin doxepin
Accupril quinapril Adaquin quinine
Accuprin quinapril Adasuve loxapine
Accupro quinapril Adcetris brentuximab vedotin
Accuretic hydrochlorothiazide, quinapril Adcirca tadalafil
Accutane isotretinoin Adderall dextroamphetamine
Acenor-M fosinopril Addyi flibanserin
Acenorm captopril Adempas riociguat
Aceon perindopril Adenic adenosine
Acepril captopril Adeno-Jec adenosine
Acerbon lisinopril Adenocard adenosine
Acertil perindopril Adenocur adenosine
Acetazolam acetazolamide Adenoject adenosine
acetylsalicylic acid aspirin Adenoscan adenosine
Acfol folic acid Adiblastine doxorubicin
aciclovir acyclovir Adipex-P phentermine
Acid A Vit tretinoin Adipine nifedipine
Acidulated phosphate fluoride fluorides Adlyxin lixisenatide
Acifur acyclovir Adocor captopril
Acimox amoxicillin Adofen fluoxetine
Aciphex rabeprazole Adoxa doxycycline
Aclasta zoledronate Adrecar adenosine
Aclinda clindamycin Adrenaclick epinephrine
CONCORDANCE Litt’s Drug Eruption & Reaction Manual
Adrenalin epinephrine Alfotax cefotaxime

adrenaline epinephrine Algocetil sulindac
Adriablastine doxorubicin Alimta pemetrexed
Adriacin doxorubicin Alinia nitazoxanide
Adriamycin doxorubicin Aliqopa copanlisib
Adriblatina doxorubicin Alka-Seltzer aspirin
Adsorbocarbine pilocarpine Alkeran melphalan
Adumbran oxazepam all-trans-retinoic acid tretinoin
Adursall ursodiol Allegra-D pseudoephedrine
Advantan methylprednisolone Allegra fexofenadine
Advicor lovastatin, niacin Allegron nortriptyline
Advil ibuprofen Aller-Chlor chlorpheniramine
Aerolate aminophylline Allerdryl diphenhydramine
Aerovent aldesleukin Allerglobuline immune globulin IV
Afaxin vitamin A Allermax diphenhydramine
Afinitor everolimus Allermin diphenhydramine
Aflodac sulindac Alli orlistat
Aflorix miconazole Allo 300 allopurinol
Afluria influenza vaccine Allo-Puren allopurinol
Afstyla antihemophilic factor Alloprin allopurinol
Aggrenox aspirin, dipyridamole Allvoran diclofenac
Agilect rasagiline Almarytm flecainide
Agisolvan acetylcysteine Almatol spironolactone
Agrippal influenza vaccine Almodan amoxicillin
AH3 N hydroxyzine Almogran almotriptan
Airol tretinoin Aloid miconazole
AK-Chlor chloramphenicol Alopexy minoxidil
Ak-Zol acetazolamide Alora estradiol
Akarpine pilocarpine Aloxi palonosetron
Akatinol memantine alpha tocopherol vitamin E
Aknemin minocycline Alphagan P brimonidine
Aknemycin Plus tretinoin Alphapress hydralazine
AKTob Ophthalmic tobramycin Alprim trimethoprim
Akynzeo netupitant & palonosetron Alprox alprazolam
AL-R chlorpheniramine Alquingel tretinoin
Alapril lisinopril Alrheumat ketoprofen
Alavert loratadine Alrheumun ketoprofen
Albenza albendazole Alsuma sumatriptan
Albiotic lincomycin Altace ramipril
Alcloxidine chlorhexidine Alten tretinoin
Alcomicinx gentamicin Alti-Diltiazem diltiazem
Aldactazide hydrochlorothiazide, spironolactone Alti-Doxepin doxepin
Aldactone spironolactone Alti-Ipratropium ipratropium
Aldara imiquimod Alti-Minocycline minocycline
Aldoclor methyldopa Alti-MPA medroxyprogesterone
Aldocumar warfarin Alti-Trazodone trazodone
Aldomet methyldopa Altocor lovastatin
Aldopur spironolactone Altoprev lovastatin
Aldoril hydrochlorothiazide, methyldopa Alunbrig brigatinib
Alecensa alectinib Aluvira lopinavir
Alendronic acid alendronate Alveolex acetylcysteine
Alepsal phenobarbital Amaryl glimepiride
Alercet cetirizine Ambi hydroquinone
Alerid cetirizine Ambien zolpidem
Alertec modafinil AmBisome amphotericin B
Alesse oral contraceptives Amdepin amlodipine
Aleve naproxen Ameluz aminolevulinic acid
Alexan cytarabine amethopterin methotrexate
Alfadil doxazosin Ametycine mitomycin
Alfatil cefaclor Amfipen ampicillin
Alferon N interferon alfa Amias candesartan
Litt’s Drug Eruption & Reaction Manual CONCORDANCE
Amicacina amikacin Antabus disulfiram

Amicasil amikacin Antabuse disulfiram
Amikacin sulfate amikacin Antagonil nicardipine
Amikal amiloride Antaxone naltrexone
Amikan amikacin antegren natalizumab
Amineurin amitriptyline Anten doxepin
Aminophyllin aminophylline Antepsin sucralfate
Amipress labetalol Antiflog piroxicam
Amisalen procainamide Antilak etodolac
Amitiza lubiprostone Antilirium physostigmine
Amjevita adalimumab Antipressan atenolol
Amlodin amlodipine Antra omeprazole
Amlogard amlodipine Antrex leucovorin
Amlopin amlodipine Apacef cefotetan
Amlor amlodipine APAP acetaminophen
Amnesteem isotretinoin Apatef cefotetan
Amodex amoxicillin Apdormin hydralazine
Amodopa methyldopa Apekumarol dicumarol
Amoxan amoxapine Aphtiria lindane
Amoxapine amoxapine Apidra insulin glulisine
Amoxil amoxicillin APO-Alpraz alprazolam
amoxycillin amoxicillin Apo-Amoxi amoxicillin
Amphocin amphotericin B Apo-Atenol atenolol
Amphotec amphotericin B Apo-Bisoprolol bisoprolol
Ampicin ampicillin Apo-Bromocriptine bromocriptine
Amprace enalapril Apo-Buspirone buspirone
Ampyra dalfampridine APO-Capto captopril
Amrix cyclobenzaprine Apo-Carbamazepine carbamazepine
Amterene triamterene Apo-Cefaclor cefaclor
Amuno indomethacin Apo-Cephalex cephalexin
Amycil mebendazole Apo-Cimetidine cimetidine
Anacin-3 acetaminophen Apo-Clomipramine clomipramine
Anacin aspirin Apo-Diclo diclofenac
Anacobin cyanocobalamin Apo-Doxy doxycycline
Anafranil Retard clomipramine Apo-Enalapril enalapril
Anafranil clomipramine Apo-Ethambutol ethambutol
Anamantle HC lidocaine Apo-Famotidine famotidine
Anamorph morphine Apo-Fenofibrate fenofibrate
Anaprox naproxen Apo-Fluoxetine fluoxetine
Anaspaz hyoscyamine Apo-Fluphenazine fluphenazine
Anatensol fluphenazine Apo-Flurbiprofen flurbiprofen
Anaxanil hydroxyzine Apo-Fluvoxamine fluvoxamine
Anco ibuprofen Apo-Folic folic acid
Andro LA testosterone Apo-Furosemide furosemide
Androcur cyproterone Apo-Gain minoxidil
Androderm testosterone Apo-Hydro hydrochlorothiazide
AndroGel testosterone Apo-Imipramine imipramine
Android methyltestosterone Apo-Indomethacin indomethacin
Andronaq testosterone Apo-ISDN isosorbide dinitrate
Androral methyltestosterone Apo-Lorazepam lorazepam
Andrumin dimenhydrinate Apo-Lovastatin lovastatin
Anectine succinylcholine Apo-Metformin metformin
Aneol ketoprofen Apo-Metronidazole metronidazole
Anergan promethazine Apo-Minocycline minocycline
Anestacon lidocaine Apo-Nadolol nadolol
Angilol propranolol Apo-Nicotinamide niacin
Angiomax bivalirudin Apo-Nifed nifedipine
Angioverin papaverine Apo-Nortriptyline nortriptyline
Anitrim co-trimoxazole Apo-Oxazepam oxazepam
Ansaid flurbiprofen Apo-Pen penicillin V
Ansail buspirone Apo-Pentoxifylline pentoxifylline
Apo-Perphenazine perphenazine Arythmol propafenone

Apo-Piroxicam piroxicam Arzerra ofatumumab
Apo-Propranolol propranolol ASA aspirin
Apo-Ranitidine ranitidine Asacol mesalamine
Apo-Selegiline selegiline Asacolitin mesalamine
Apo-Sulfatrim co-trimoxazole Asclera polidocanol
APO-Sulin sulindac Ascriptin aspirin
Apo-Tamox tamoxifen Asendis amoxapine
Apo-Temazepam temazepam Aside etoposide
Apo-Tetra tetracycline Asig quinapril
Apo-Trimip trimipramine Asmaven albuterol
APO-Verap verapamil Aspergum aspirin
Apocard flecainide Aspro aspirin
Aponal doxepin ASS aspirin
Apranax naproxen Assival diazepam
Apresazide hydralazine AsthmaHaler epinephrine
Apresolin hydralazine Astramorph morphine
Apresoline hydralazine Atabrine quinacrine
Aprical nifedipine Atacand HCT hydrochlorothiazide
Aprovel irbesartan Atacand candesartan
Apsifen ibuprofen Ataline terbutaline
Apsolol propranolol Atarax hydroxyzine
Aptiom eslicarbazepine AteHexal atenolol
Aptivus tipranavir Atelvia risedronate
Aquachloral chloral hydrate Atem aldesleukin
Aquamid hyaluronic acid Atendol atenolol
Aquamycetin chloramphenicol Atisuril allopurinol, salsalate
Aquarius ketoconazole Ativan lorazepam
Aquasol A vitamin A Atosil promethazine
Aquasol E vitamin E ATP adenosine
ara-C cytarabine ATRA tretinoin
Arabitin cytarabine Atragen tretinoin
Arace cytarabine Atrenta artesunate
Aracytine cytarabine Atreol carbamazepine
Aragest 5 medroxyprogesterone Atridox doxycycline
Aralen chloroquine Atripla efavirenz, emtricitabine, tenofovir disoproxil
Aranesp darbepoetin alfa Atronase aldesleukin
Aratac amiodarone Atropine Martinet atropine sulfate
Arcapta Neohaler indacaterol Atropt atropine sulfate
Aredia pamidronate Atrovent ipratropium
Arestin minocycline Atruline sertraline
Argesic-SA salsalate Aubagio teriflunomide
Aricept Evess donepezil Audazol omeprazole
Aricept donepezil Augmentin amoxicillin
Arimidex anastrozole Austedo deutetrabenazine
Aristada aripiprazole Autologen collagen (bovine)
Arixtra fondaparinux Auvi-Q epinephrine
Aromasin exemestane Avage tazarotene
Arovit vitamin A Avalide hydrochlorothiazide, irbesartan
Arpamyl LP verapamil Avandamet metformin, rosiglitazone
Arsacol ursodiol Avandaryl glimepiride, rosiglitazone
Artal pentoxifylline Avandia rosiglitazone
Artamin penicillamine Avapro irbesartan
Artecoll collagen (bovine) Avastin bevacizumab
Artha-G salsalate Avaxim hepatitis A vaccine
Arthaxan nabumetone Avelox moxifloxacin
Arthro-Aid glucosamine Aventyl nortriptyline
Arthrocine sulindac Aviane oral contraceptives
Arthrotec diclofenac, misoprostol Avinza morphine
Artifar carisoprodol Avipur vitamin A
ARTZ hyaluronic acid Avirax acyclovir
Avita tretinoin Basaglar insulin glargine

Avitcid tretinoin Basoquin amodiaquine
Avitene collagen (bovine) Batrizol co-trimoxazole
Avitin vitamin A Bavencio avelumab
Avitoin tretinoin Baxan cefadroxil
Avloclor chloroquine Baxdela delafloxacin
Avlosulfon dapsone Baxo piroxicam
Avodart dutasteride Baygam immune globulin IV
Avonex interferon beta Baymycard nisoldipine
Avycaz ceftazidime & avibactam BB clindamycin
Axerol vitamin A Beatryl fentanyl
Axert almotriptan Becenun carmustine
Axoban ranitidine Beconase AQ beclomethasone
Aygestin progestins Begrivac influenza vaccine
Azamedac azathioprine Behapront phentermine
Azamune azathioprine Beleodaq belinostat
Azantac ranitidine Belladenal atropine sulfate
Azasan azathioprine Bellafill collagen (bovine)
AzaSite azithromycin Bellergal-S atropine sulfate
Azatrilem azathioprine Beloc-Zoc metoprolol
Azenil azithromycin Belsomra suvorexant
azidothymidine zidovudine Belviq lorcaserin
Azilect rasagiline Benadryl diphenhydramine, pseudoephedrine
Azitrocin azithromycin Benahist diphenhydramine
Azitromax azithromycin Benaxima cefotaxime
Azol danazol Benaxona ceftriaxone
Azopt brinzolamide Bencid probenecid
AZT zidovudine Benecid probenecid
Azucimet cimetidine Benhex Cream lindane
Azulfidine sulfasalazine Benicar olmesartan
Azupamil verapamil Benuryl probenecid
Azupentat pentoxifylline Benylin dextromethorphan, diphenhydramine
Azutranquil oxazepam Benzaclin clindamycin
Azzalure botulinum toxin (A & B) Benzamin cyclobenzaprine
Benzylpenicillin penicillin G
B Beriglobulin immune globulin IV
Bacille Calmette-Guerin BCG vaccine Berkatens verapamil
Baclofen baclofen Berlthyrox levothyroxine
Baclon baclofen Berubigen cyanocobalamin
Baclosal baclofen Bespar buspirone
Bacomine hydrocodone Besponsa inotuzumab ozogamicin
Bactelan co-trimoxazole Beta-Adalat atenolol
Bactin trimethoprim Beta-Cardone sotalol
Bactocill oxacillin Betades sotalol
Bactocin ofloxacin Betaferon interferon beta
Bactoscrub chlorhexidine Betaloc metoprolol
BactoShield chlorhexidine Betanis mirabegron
Bactrim co-trimoxazole, sulfamethoxazole, trimethoprim Betapace sotalol
Baklofen baclofen Betasept chlorhexidine
BAL5788 ceftobiprole Betaseron interferon beta
Balcoran vancomycin Betazok metoprolol
Balminil dextromethorphan, pseudoephedrine Betolvex cyanocobalamin
Ban-Tuss HC hydrocodone Betoptic [Ophthalmic] betaxolol
Banophen diphenhydramine Betoptic S betaxolol
Bantenol mebendazole Betoptima betaxolol
Baraclude entecavir Bevyxxa betrixaban
Barazan norfloxacin Bex aspirin
Barbilixir phenobarbital Bexsero meningococcal group B vaccine
Barbita phenobarbital BG-12 dimethyl fumarate
Barbital phenobarbital Bi-Profenid ketoprofen
Barclyd clonidine Biaxin HP clarithromycin
Biaxin clarithromycin Bronkaid epinephrine

Bicide lindane Bronkodyl aminophylline
Biclin amikacin Brothine terbutaline
BiCNU carmustine Brovana arformoterol
Bidocef cefadroxil Brufen ibuprofen
Biklin amikacin Bucaril terbutaline
Biliepar ursodiol Bufigen nalbuphine
Bilim tamoxifen Busetal disulfiram
Biltricide praziquantel Busirone buspirone
Bimaran trazodone BuSpar buspirone
Binocrit epoetin alfa Bustab buspirone
Binosto alendronate Butaline terbutaline
Binotal ampicillin Butibel atropine sulfate
Bio E vitamin E Bydureon exenatide
Bio-Well lindane Byetta exenatide
Biocet cephalexin Bystolic nebivolol
Biocoryl procainamide Byvalson nebivolol, valsartan
Biofanal nystatin
Biosint
BioThrax
cefotaxime
anthrax vaccine
C
Caduet amlodipine, atorvastatin
Biozolene fluconazole Calamine zinc
Biron buspirone Calan verapamil
Bismatrol bismuth Calcicard diltiazem
Bismuth Iodoform Paraffin Paste (BIPP) bismuth calcidiol calcifediol
Bismuth subcitrate bismuth Calcidrine codeine
Bismuth subgallate bismuth Calcilat nifedipine
Bismuth sucralfate bismuth Calcilean heparin
Bleminol allopurinol Calcimar calcitonin
Blenoxane bleomycin Calciparin heparin
bleo bleomycin calcipotriene calcipotriol
Bleocin bleomycin Calm-X dimenhydrinate
Bleomycine bleomycin Caltine calcitonin
Bleomycinum bleomycin Calypsol ketamine
Blephamide prednisolone Cambia diclofenac
Blincyto blinatumomab Camochin amodiaquine
BLM bleomycin Camoquin amodiaquine
Blocan cimetidine Camoquinal amodiaquine
Bobsule hydroxyzine Campath alemtuzumab
Bocouture botulinum toxin (A & B) Camptosar irinotecan
Bolutol gemfibrozil Canasa mesalamine
Bondronat ibandronate Cancidas caspofungin
Boniva ibandronate Candio-Hermal nystatin
Bonnox promethazine cannabis marihuana
Bonzol danazol Caplenal allopurinol
Botox botulinum toxin (A & B) Capoten captopril
Brek loperamide Capozide captopril, hydrochlorothiazide
Brethine terbutaline Caprelsa vandetanib
Brevibloc esmolol Caprilon tranexamic acid
Brevicon oral contraceptives Caprin aspirin, heparin
Bricanyl terbutaline Captolane captopril
Bridion sugammadex Captoril captopril
Brilinta ticagrelor Carac fluorouracil
Brisdelle paroxetine mesylate Carace lisinopril
Bristopen oxacillin Carafate sucralfate
Britiazem diltiazem Carbatrol carbamazepine
Briviact brivaracetam Carbex selegiline
Brocadopa levodopa carbidopa levodopa
Bromed bromocriptine Carbolith lithium
Bromfed pseudoephedrine Carbometyx cabozantinib
Broncho-Spray albuterol Carboplat carboplatin
Bronitin epinephrine Carbosap anthrax vaccine
Carbosin carboplatin Ceporex cephalexin

Carcinil leuprolide Ceporexine cephalexin
Cardem celiprolol Ceptaz ceftazidime
Cardene nicardipine Cerdelga eliglustat
Cardicor bisoprolol Cerepax temazepam
Cardigox digoxin Certican everolimus
Cardine quinidine Cerubidine daunorubicin
Cardiosteril dopamine Cervarix human papillomavirus vaccine (bivalent)
Cardizem diltiazem Cervidel dinoprostone
Cardol sotalol Cerviprime dinoprostone
Cardoxan doxazosin Cerviprost dinoprostone
Cardoxin dipyridamole Cesamet nabilone
Cardular doxazosin Cetrine cetirizine
Cardura doxazosin Cetrotide cetrorelix
Carisoma carisoprodol Cezin cetirizine
Carmubris carmustine Champix varenicline
Cartia-XT diltiazem Chantix varenicline
Casodex bicalutamide Chemet succimer
Cassadan alprazolam Cheracol-D dextromethorphan
Cataflam diclofenac Cheracol codeine
Catapres clonidine Chibro-Atropine atropine sulfate
Catapresan clonidine Chibroxin norfloxacin
Caved-S bismuth Chibroxine norfloxacin
Caverject alprostadil Chibroxol norfloxacin
CDDP cisplatin Chinine quinine
Cebenicol chloramphenicol Chitosamine glucosamine
Cebutid flurbiprofen Chlo-Amine chlorpheniramine
CEC 500 cefaclor Chlor-Pro chlorpheniramine
Ceclor cefaclor Chlor-Trimeton chlorpheniramine
Cedocard isosorbide dinitrate Chlor-Tripolon chlorpheniramine
Cedrox cefadroxil Chloractil chlorpromazine
Cefabiocin cefaclor Chloraldurat chloral hydrate
cefalexin cephalexin Chlorate chlorpheniramine
Cefamox cefadroxil Chlorazin chlorpromazine
Cefaxim cefotaxime Chlorhexamed chlorhexidine
Cefaxona ceftriaxone Chloroptic chloramphenicol
Cefaxone ceftriaxone chlorphenamine chlorpheniramine
Ceforal cephalexin Chlorpromanyl chlorpromazine
Cefotan cefotetan Chlorquin chloroquine
Cefotax cefotaxime Chol-Less cholestyramine
Cefspan cefixime Cholacid ursodiol
Ceftazim ceftazidime Cholbam cholic acid
Ceftenon cefotetan Choledyl aminophylline
Ceftin cefuroxime Cholestagel colesevelam
Cefuril cefuroxime Cholit-Ursan ursodiol
Celebrex celecoxib Cholofalk ursodiol
Celectol celiprolol Chronovera verapamil
Celexa citalopram Cialis tadalafil
Celipres celiprolol Cibacalcine calcitonin
Celipro celiprolol Cibace benazepril
CellCept mycophenolate Cibacen benazepril
Cellmusin estramustine Cibacene benazepril
Celol celiprolol Ciclosporin cyclosporine
Celsentri maraviroc Cidomycin gentamicin
Celupan naltrexone Ciflox ciprofloxacin
Celvapan pandemic influenza vaccine (H1N1) Cillimicina lincomycin
Cemidon isoniazid Cillimycin lincomycin
Centedrin methylphenidate Ciloxan Ophthalmic ciprofloxacin
Cepan cefotetan Cimedine cimetidine
Cepazine cefuroxime Cimehexal cimetidine
Cephoral cefixime Cimogal ciprofloxacin
Cimzia certolizumab Colazal balsalazide

Cin-Quin quinidine Colazide balsalazide
Cinqair reslizumab ColBenemid colchicine
Ciplox ciprofloxacin Colchiquim colchicine
Cipramil citalopram Colcrys colchicine
Cipro ciprofloxacin Cold-Eeze zinc
Ciprobay Uro ciprofloxacin Coledos ursodiol
Cipromycin ciprofloxacin Colestrol cholestyramine
Ciproxin ciprofloxacin Colgout colchicine
Cisplatyl cisplatin Colo-Fresh bismuth
Cisticid praziquantel Colo-Pleon sulfasalazine
Citanest prilocaine Combivent albuterol, ipratropium
Citax immune globulin IV Combivir lamivudine, zidovudine
Citosulfan busulfan Cometriq cabozantinib
Citrec leucovorin Compazine prochlorperazine
citrovorum factor leucovorin Complera emtricitabine, tenofovir disoproxil
Ciuk cimetidine Compoz diphenhydramine
Civeran loratadine Comtan entacapone
Clacine clarithromycin Comtess entacapone
Claforan cefotaxime Comvax Hemophilus B vaccine, hepatitis B vaccine,
Clamoxyl amoxicillin influenza vaccine
Claragine aspirin Concerta methylphenidate
Claratyne loratadine Concor bisoprolol
Claravis isotretinoin Consolan nabumetone
Clarinex desloratadine Consupren cyclosporine
Clarith clarithromycin Contalgin morphine
Claritin-D loratadine Contergan thalidomide
Claritin loratadine Contigen collagen (bovine)
Claritine loratadine Contramal tramadol
Clarus isotretinoin Contrave naltrexone
Classen mercaptopurine Convon terbutaline
Clasynar calcitonin Copaxone glatiramer
Claversal mesalamine Copegus ribavirin
Cleocin-T clindamycin copolymer-1 glatiramer
Cleocin clindamycin Coracten nifedipine
Cleridium dipyridamole Coradur isosorbide dinitrate
Clexane enoxaparin Corax chlordiazepoxide
Climara estradiol Corbionax amiodarone
Clindacin clindamycin Cordarex amiodarone
Clindagel clindamycin Cordarone X amiodarone
Clindets clindamycin Cordarone amiodarone
Clinofem medroxyprogesterone Cordes VAS tretinoin
Clinoril sulindac Cordiax celiprolol
Cloben cyclobenzaprine Cordilox verapamil
Clofen baclofen Coreg carvedilol
Clofranil clomipramine Corflene flecainide
Clonex clonazepam Corgard nadolol
Clont metronidazole Coric lisinopril
Clopress clomipramine Coricidin D aspirin
Closerin cycloserine Corifam rifampin
Closerina cycloserine Corlanor ivabradine
Closin promethazine Corogal nifedipine
Clothia hydrochlorothiazide Coronarine dipyridamole
Clozaril clozapine Corophyllin aminophylline
club drug MDMA Corotrend nifedipine
Coartem artemether/lumefantrine Coroxin dipyridamole
Cobex cyanocobalamin Corsodyl chlorhexidine
Cobutolin albuterol Cortastat dexamethasone
Codamine hydrocodone Cortone cortisone
Codicept codeine Cortosporin neomycin
Codiforton codeine Corvert ibutilide
Corzide nadolol D-Zol danazol

Cosentyx secukinumab D4T stavudine
Cosmegen Lyovac dactinomycin Dacatic dacarbazine
Cosmegen dactinomycin Dacogen decitabine
Cosopt dorzolamide Dagan nicardipine
Cotellic cobimetinib Daipres clonidine
Cotempla methylphenidate Daklinza daclatasvir
Cotrim co-trimoxazole Daktarin miconazole
Coumadin warfarin Dalacin C clindamycin
Coumadine warfarin Dalacin clindamycin
Covera-HS verapamil Dalacine clindamycin
Coversum perindopril Daliresp roflumilast
Coversyl perindopril Dalisol folic acid
Cozaar losartan Danocrine danazol
CPM cyclophosphamide Danol danazol
Cranoc fluvastatin Dantamacrin dantrolene
Crasnitin asparaginase Dantrium dantrolene
Cresemba isavuconazonium sulfate Dantrolen dantrolene
Crestor rosuvastatin Daonil glyburide
Crixivan indinavir Dapa-tabs indapamide
Cryocriptina bromocriptine Dapatum D25 fluphenazine
Cryodoxin sulfadoxine Dapotum D fluphenazine
Cryptaz nitazoxanide Dapson-Fatol dapsone
Crystamine cyanocobalamin Dapson dapsone
Crystapen penicillin G Daraprim pyrimethamine
Crysti-12 cyanocobalamin Darvocet-N acetaminophen
CsA cyclosporine Darvon Compound aspirin
CTX cyclophosphamide Darzalex daratumumab
Cubicin daptomycin daunomycin daunorubicin
Curantyl N dipyridamole DaunoXome daunorubicin
Curretab progestins Davedax reboxetine
Cuvitru immune globulin sc Davesol lindane
Cuvposa glycopyrrolate Davitamon E vitamin E
CyA cyclosporine Daxas roflumilast
Cyanoject cyanocobalamin Daypro oxaprozin
Cyben cyclobenzaprine Daytrana methylphenidate
Cycloblastin cyclophosphamide Dazamide acetazolamide
Cyclomen danazol DDAVP desmopressin
Cyclomycin cycloserine ddC zalcitabine
Cyclorine cycloserine De-Nol bismuth
Cyclostin cyclophosphamide Deca-Durabolin nandrolone
Cycosin cycloserine Decadron dexamethasone
Cyklokapron tranexamic acid Decentan perphenazine
Cymbalta duloxetine Deconsal pseudoephedrine
Cynomel liothyronine Decrelip gemfibrozil
Cyomin cyanocobalamin Dedralen doxazosin
Cyramza ramucirumab Defanyl amoxapine
Cystrin oxybutynin Defiltran acetazolamide
CYT cyclophosphamide Defirin desmopressin
Cytamen cyanocobalamin Defitelio defibrotide
Cytarbel cytarabine Deflam oxaprozin
Cytomel liothyronine Dehydrobenzperidol droperidol
Cytosar-U cytarabine Delatest testosterone
Cytosar cytarabine Delatestryl testosterone
Cytospaz hyoscyamine Delice lindane
Cytotec misoprostol Delsym dextromethorphan
Cytoxan cyclophosphamide Delta-Cortef prednisolone
Delta-Lutin progestins
D Deltasone prednisone
D-Amp ampicillin Deltazen diltiazem
D-Penamine penicillamine Delursan ursodiol
Demadex torsemide Diaformin metformin

Demerol meperidine Dialar diazepam
Demolox amoxapine Diamox acetazolamide
Demulen oral contraceptives Diapax diazepam
Denan simvastatin Diar-Aid loperamide
Densul methyldopa Diarr-Eze loperamide
Dentipatch lidocaine Diarrol triamterene
Denzapine clozapine Diarstop-L loperamide
Depacon valproic acid Diastat diazepam
Depade naltrexone Diatracin vancomycin
Depakene valproic acid Diazemuls diazepam
Depakote valproic acid Diazid isoniazid
Depen penicillamine Dibloc carvedilol
Depo-Provera medroxyprogesterone Diblocin doxazosin
DepoCyt cytarabine Dibrondrin diphenhydramine
Deprax trazodone DIC dacarbazine
deprenyl selegiline Dichlotride hydrochlorothiazide
Derm A tretinoin Dicolmax diclofenac
DermaDeep hyaluronic acid Dicumarol dicumarol
DermaFlex lidocaine Dicumol dicumarol
Dermairol tretinoin dideoxycytidine zalcitabine
DermaLive hyaluronic acid Didronate etidronate
Dermalogen collagen (bovine) Didronel etidronate
Dermojuventus tretinoin Differin adapalene
Desconex loxapine Diflucan fluconazole
Descovy emtricitabine, tenofovir alafenamide Diformin metformin
Deseril methysergide Difosfen etidronate
Desernil methysergide Digacin digoxin
Deserril methysergide Digoxine digoxin
Deseryl methysergide Dilacor XR diltiazem
Desferal deferoxamine Dilanorm celiprolol
Desferin deferoxamine Dilantin phenytoin
Desirel trazodone Dilatrate-SR isosorbide dinitrate
Desmospray desmopressin Dilatrend carvedilol
Desocol ursodiol Dilaudid-HP hydromorphone
Desogen oral contraceptives Dilaudid hydromorphone
Desoxil ursodiol Dilocaine lidocaine
Desoxyn methamphetamine Dilrene diltiazem
Destolit ursodiol Diltahexal diltiazem
Desyrel trazodone Diltia-XT diltiazem
Detensol propranolol Dimetabs dimenhydrinate
Deticene dacarbazine dimethyl (E) butenedioate dimethyl fumarate
Detimedac dacarbazine Diminex phentermine
Detrol tolterodine Dimitone carvedilol
Detulin vitamin E Dimodan disopyramide
Deurcil ursodiol Dinol etidronate
Devrom bismuth Diocarpine pilocarpine
Dexacine neomycin Diochloram chloramphenicol
Dexambutol ethambutol Diogent gentamicin
Dexamphetamine dextroamphetamine Dionephrine phenylephrine
Dexamphetamini dextroamphetamine Diotame bismuth
Dexedrine dextroamphetamine Diovan HCT hydrochlorothiazide, valsartan
Dexilant dexlansoprazole Diovan valsartan
Dexo ursodiol Diphenylan phenytoin
Dexone dexamethasone diphenylhydantoin phenytoin
Dextrostat dextroamphetamine Diphos etidronate
DHC-Continus dihydrocodeine Dipridacot dipyridamole
Di-Hydran phenytoin Diprivan propofol
Diabeta glyburide Diram spironolactone
Diabex metformin Dirythmin SA disopyramide
diacetylmorphine heroin Disalgesic salsalate
Discoid furosemide DTIC-Dome dacarbazine

Disonorm disopyramide DTIC dacarbazine
Disprin aspirin Duboisine hyoscyamine
Distaclor cefaclor Ducene diazepam
Distamine penicillamine Duexis famotidine
Distaval thalidomide Dulera formoterol
Distocide praziquantel Dumirox fluvoxamine
Ditropan oxybutynin Dumyrox fluvoxamine
Diu-Melsin hydrochlorothiazide Dunate artesunate
Diuchlor H hydrochlorothiazide Duoneb albuterol, ipratropium
Diuramid acetazolamide Duopa levodopa
Diuteren triamterene Dupixent dupilumab
divalproex valproic acid Dura-Vent phenylephrine
Divigel estradiol Duracef cefadroxil
Dixarit clonidine Duraclon clonidine
Dizac diazepam Duragesic fentanyl
DMSA succimer Duralith lithium
DNR daunorubicin Duralutin progestins
Dobetin cyanocobalamin Durametacin indomethacin
Doblexan piroxicam Duramorph morphine
Dolac ketorolac Duraperidol haloperidol
Dolantin meperidine Duraprox oxaprozin
Dolce vitamin A Durater famotidine
Dolestan diphenhydramine Duratest testosterone
Dolestine meperidine Duratuss hydrocodone
Dolophine methadone Durazepam oxazepam
Dolosal meperidine Durazolam lorazepam
Dom-Baclofen baclofen Durbis disopyramide
Dom-Fluoxetine fluoxetine Duricef cefadroxil
Domical amitriptyline Durlaza aspirin
Doneurin doxepin Duzallo allopurinol, lesinurad
Donnagel atropine sulfate Dyazide hydrochlorothiazide, triamterene
Donnamar hyoscyamine Dyloject diclofenac
Donnatal atropine sulfate Dymenalgit naproxen
Donnazyme atropine sulfate Dyna-Hex chlorhexidine
Dopaflex levodopa Dynacil fosinopril
Dopamet methyldopa Dynacin minocycline
Dopamin AWD dopamine Dynacirc SRO isradipine
Dopamin dopamine DynaCirc isradipine
Doparl levodopa Dynatra dopamine
Dopastat dopamine Dyrenium triamterene
Dormicum midazolam Dysman mefenamic acid
Doryx doxycycline Dyspamet cimetidine
Dostinex cabergoline Dysport botulinum toxin (A & B)
Dovonex calcipotriol Dytac triamterene
Doxil doxorubicin
Doximed doxycycline E
Doxy-100 doxycycline E Perle vitamin E
Doxycin doxycycline E-Mycin erythromycin
Doxytec doxycycline E-Pam diazepam
Dozic haloperidol E-Vitamin Succinate vitamin E
DPH phenytoin E102 tartrazine
Dramamine dimenhydrinate E MDMA
Dridase oxybutynin Ebixa memantine
Drogenil flutamide Ebufac ibuprofen
Droleptan droperidol Ecalta anidulafungin
Droperidol droperidol Ecomucyl acetylcysteine
Droxia hydroxyurea Economycin tetracycline
Droxine levothyroxine Ecotrin aspirin
Dryptal furosemide Ecridoxan etodolac
Dryvax smallpox vaccine ecstasy MDMA
Ectaprim co-trimoxazole Enapren enalapril

Ectasule ephedrine Enarmon methyltestosterone
ED-SPAZ hyoscyamine Enbrel etanercept
Edenol furosemide Encore acetylcysteine
Edex alprostadil Endeavor zotarolimus
Edisylate prochlorperazine Endep amitriptyline
Edolan etodolac Endobulin immune globulin IV
Edronax reboxetine Endocodone oxycodone
EES erythromycin Endoxan cyclophosphamide
Efedron ephedrine Endoxana cyclophosphamide
Eferox levothyroxine Ener-B cyanocobalamin
Effexor XL venlafaxine Engerix B hepatitis B vaccine
Effexor venlafaxine Entex HC hydrocodone
Effient prasugrel Entex pseudoephedrine
Efracea doxycycline Entresto sacubitril/valsartan
Efudex fluorouracil Entumin clozapine
Efudix fluorouracil Entumine clozapine
Efurix fluorouracil Entyvio vedolizumab
Egacene Durettes hyoscyamine Envarsus XR tacrolimus
Egazil hyoscyamine Epanutin phenytoin
ELA-Max lidocaine Epaxal hepatitis A vaccine
Elavil amitriptyline Epclusa sofosbuvir & velpatasvir
Eldeprine selegiline Ephedsol ephedrine
Eldepryl selegiline Ephynal vitamin E
Elderin etodolac Epi E-Z Pen epinephrine
Eldopal levodopa Epi-Aberel tretinoin
Elentol lindane Epiduo adapalene
Elepsia XR levetiracetam Epifrin epinephrine
Elestrin estradiol Epimorph morphine
Elidel pimecrolimus Epipen epinephrine
Eligard leuprolide Epitol carbamazepine
Eliquis apixaban Epivir lamivudine
Elisor pravastatin EPO epoetin alfa
Elixophyllin aminophylline Epogen epoetin alfa
Ellence epirubicin Epoxitin epoetin alfa
Elobact cefuroxime Eppy epinephrine
Eloctate antihemophilic factor Eppystabil epinephrine
Elorgan pentoxifylline Eprex epoetin alfa
Eloxatin oxaliplatin Eprolin vitamin E
Elspar asparaginase Eptadone methadone
Eltor 120 pseudoephedrine Epzicom abacavir, lamivudine
Eltroxin levothyroxine Equagesic aspirin
EMB ethambutol Equibar methyldopa
Embolin dicumarol Eramycin erythromycin
Emcor bisoprolol Eraxis anidulafungin
Emcyt estramustine Erbaprelina pyrimethamine
Emend aprepitant Erbitux cetuximab
Emeset ondansetron Ercar carboplatin
Emeside ethosuximide Ercoquin hydroxychloroquine
Emflaza deflazacort Erelzi etanercept
EMLA lidocaine Ergomar ergotamine
Emorhalt tranexamic acid Ergometrine ergometrine
Empirin aspirin Ergostat ergotamine
Empliciti elotuzumab Erivedge vismodegib
Emquin chloroquine Ery-Ped erythromycin
Emsam selegiline Ery-Tab erythromycin
Emselex darifenacin Eryc erythromycin
Emtriva emtricitabine Erypar erythromycin
Enablex darifenacin Erypo epoetin alfa
Enaladil enalapril Erythrocin erythromycin
Enantone leuprolide erythropoiesis stimulating protein darbepoetin alfa
erythropoietin epoetin alfa Famodil famotidine

Eryzole erythromycin Famoxal famotidine
Esbriet pirfenidone Famvir famciclovir
Esclim estradiol Fanapt iloperidone
eserine physostigmine Fansidar pyrimethamine, sulfadoxine
Esidrex hydrochlorothiazide Fareston toremifene
Eskalith lithium Farmablastina doxorubicin
Esmino chlorpromazine Farmagard nadolol
Esperal disulfiram Farxiga dapagliflozin
Estazor ursodiol Farydak panobinostat
Esteprim co-trimoxazole Faverin fluvoxamine
Estrace estradiol Favoxil fluvoxamine
Estraderm estradiol FazaClo clozapine
Estratest methyltestosterone FD&C yellow No.5 tartrazine
Estring estradiol Felden piroxicam
Estrogel estradiol Feldene piroxicam
Estrostep oral contraceptives Femara letrozole
Etapiam ethambutol Fempatch estradiol
Ethymal ethosuximide Fenac diclofenac
Etibi ethambutol Fentanest fentanyl
Etopos etoposide Fentazin perphenazine
Etosid etoposide Fenytoin phenytoin
Etrafon perphenazine Feraheme ferumoxytol
Eucrisa crisaborole Ferndex dextroamphetamine
Eudigox digoxin Ferriprox deferiprone
Eudyna tretinoin Fetzima levomilnacipran
Euflex flutamide Fevarin fluvoxamine
Euflexxa hyaluronic acid Fexmid cyclobenzaprine
Euglucan glyburide Fibrel collagen (bovine)
Euglucon glyburide Fibrocit gemfibrozil
Euhypnos temazepam Fiorinal aspirin
Eulexin flutamide fisalamine mesalamine
Eulexine flutamide Fisamox amoxicillin
Eupen amoxicillin Fixime cefixime
Euphyllin aminophylline Flagyl metronidazole
Evamist estradiol Flanax naproxen
Evista raloxifene Flavoquin amodiaquine
Evitocor atenolol Flecaine flecainide
Evomela melphalan Flector Patch diclofenac
Evotaz atazanavir Flexeril cyclobenzaprine
Evoxac cevimeline Flexiban cyclobenzaprine
Evra oral contraceptives Flexitec cyclobenzaprine
Evzio naloxone Flexyx flucloxacillin
Exacyl tranexamic acid Flobasin ofloxacin
Exalgo hydromorphone Flodine folic acid
Excedrin acetaminophen, aspirin Flolan epoprostenol
Exelon rivastigmine Flomax tamsulosin
Exforge amlodipine, valsartan Flopen flucloxacillin
Exidine Scrub chlorhexidine Florazole metronidazole
Exjade deferasirox Florid miconazole
Exocine ofloxacin Florocycline tetracycline
Exodus nicotine Floxan ofloxacin
Exomuc acetylcysteine Floxapen flucloxacillin
Extavia interferon beta Floxil ofloxacin
Eylea aflibercept Floxin ofloxacin
Ezetrol ezetimibe Floxstat ofloxacin
Fluad influenza vaccine
F Fluarix influenza vaccine
Fabior tazarotene Flucazol fluconazole
Fabrol acetylcysteine Flucinom flutamide
Falciquin artesunate Fluclox flucloxacillin
Fluctin fluoxetine Funcort miconazole

Fluctine fluoxetine Fungarest ketoconazole
Fludac fluoxetine Fungata fluconazole
Fludara fludarabine Fungilin amphotericin B
Fludecate fluphenazine Fungizone amphotericin B
Fludex indapamide Fungoid Tincture miconazole
Fluimucil acetylcysteine Fungoral ketoconazole
Flukacide praziquantel Furadantin nitrofurantoin
Fluken flutamide Furadantina nitrofurantoin
Flukezol fluconazole Furadoine nitrofurantoin
Flulem flutamide Furalan nitrofurantoin
FluMist influenza vaccine Furan nitrofurantoin
Fluorophosphate fluorides Furobactina nitrofurantoin
Fluoroplex fluorouracil Furorese furosemide
Fluorouracil Injection, USP fluorouracil Furoside furosemide
Fluoxac fluoxetine Fusid furosemide
Fluoxeren fluoxetine Fuzeon enfuvirtide
Flurix influenza vaccine Fycompa perampanel
Flurofen flurbiprofen
Flurozin
Fluviral
flurbiprofen
influenza vaccine
G
G-Well lindane
Fluxil fluoxetine GAB lindane
Fluzone fluconazole, influenza vaccine Gabbroral paromomycin
Focalin dexmethylphenidate Gabitril tiagabine
Focetria pandemic influenza vaccine (H1N1) Gablofen baclofen
folacin folic acid Gabrilen Retard ketoprofen
folate folic acid Gabroral paromomycin
Folina folic acid Galecin clindamycin
folinic acid leucovorin Galedol diclofenac
Folinsyre folic acid Galmax ursodiol
Folitab folic acid Galzin zinc
Folsan folic acid Gamabenceno lindane
Fontex fluoxetine Gamafine immune globulin IV
Foradil formoterol Gamastan immune globulin IV
Formula-Q quinine Gambex lindane
Forsteo teriparatide Gamene lindane
Fortamet metformin Gamikal amikacin
Fortaz ceftazidime Gamimune immune globulin IV
Forteo teriparatide Gamma 16 immune globulin IV
Fortesta testosterone gamma benzene hexachloride lindane
Fortipine nifedipine Gammabulin immune globulin IV
Fortum ceftazidime Gammagard immune globulin IV
Forvade cidofovir Gammalin lindane
Fosalan alendronate Gammar PIV immune globulin IV
Fosamax alendronate Gammer-IV immune globulin IV
Fosinorm fosinopril Gammonayiv immune globulin IV
Foxsalepsin carbamazepine Gamunex immune globulin IV
Fozitec fosinopril Ganor famotidine
Fragmin dalteparin Garamycin gentamicin
Fragmine dalteparin Garatec gentamicin
Fraurs ursodiol Gardasil human papillomavirus (HPV) vaccine
Frenal pimozide Gardenal phenobarbital
Froben flurbiprofen Gastro famotidine
Froxal cefuroxime Gastrodyn glycopyrrolate
Frusid furosemide Gastroloc omeprazole
Fugerel flutamide Gastrosed hyoscyamine
Fulcin griseofulvin Gattex teduglutide
Fulvicin griseofulvin Gazyva obinutuzumab
Fulvina P/G griseofulvin GBH lindane
Fulyzaq crofelemer Geangin verapamil
Fumaderm dimethyl fumarate Gelnique oxybutynin
Gelprin aspirin Grifulvin V griseofulvin

Geluprane acetaminophen Gris-PEG griseofulvin
Gemicina neomycin Grisefuline griseofulvin
Gemlipid gemfibrozil Griseostatin griseofulvin
Gemzar gemcitabine Grisovin griseofulvin
Gen-Baclofen baclofen Guiatuss AC codeine
Gen-Fibro gemfibrozil Gynodiol estradiol
Gen-Metformin metformin
Gen-XENE
Genabid
clorazepate
papaverine
H
Habitrol Patch nicotine
Genahist diphenhydramine Haemiton clonidine
Genin quinine Haemopressin terlipressin
Genoptic gentamicin Hairgaine minoxidil
Genora oral contraceptives Halaven eribulin
Genoxal cyclophosphamide Haldol haloperidol
Genpril ibuprofen Halfprin aspirin
Gentacidin gentamicin Haloper haloperidol
Gentalline gentamicin Halotussin codeine
Gentalol gentamicin Haltran ibuprofen
Genvoya cobicistat/elvitegravir/emtricitabine/tenofovir Hamarin allopurinol
alafenamide Harkoseride lacosamide
Geodon ziprasidone Harvoni ledipasvir & sofosbuvir
Geroxalen methoxsalen hashish marihuana
Gestapuran medroxyprogesterone Havrix hepatitis A vaccine
Gesterol 50 progestins Heitrin terazosin
Gevilon Uno gemfibrozil Helidac bismuth, tetracycline
Gilenya fingolimod Heliopar chloroquine
Gilex doxepin Helminzole mebendazole
Gilotrif afatinib Heloxatin oxaliplatin
Glatopa glatiramer Hemangeol propranolol
Gleevec imatinib Hemi-Daonil glyburide
Gliadel Wafer carmustine Hemovas pentoxifylline
glibenclamide glyburide Henexal furosemide
Glibenese glipizide Hep-Flush heparin
Glimel glyburide Hep-Lock heparin
Glioten enalapril Hepalean heparin
Glipid glipizide Heparin-Leo heparin
Glivec imatinib Heparine heparin
Glucagon Emergency Kit glucagon Hepsera adefovir
Glucal glyburide Herceptin trastuzumab
Glucobay acarbose Herklin lindane
Glucomet metformin Heroin heroin
Glucophage metformin Herpefug acyclovir
Glucosamine sulfate glucosamine Hetlioz tasimelteon
Glucotrol glipizide hexachlorocyclohexane lindane
Glucovance glyburide, metformin Hexadrol dexamethasone
Gluquine quinidine Hexicid lindane
glybenclamide glyburide Hexit lindane
glyceryl trinitrate nitroglycerin Hexol chlorhexidine
glycopyrronium bromide glycopyrrolate Hibiclens chlorhexidine
Glyde glipizide Hibident chlorhexidine
Glynase glyburide Hibidil chlorhexidine
Glypressin terlipressin Hibiscrub chlorhexidine
Glyxambi empagliflozin, linagliptin Hibistat chlorhexidine
GoNitro nitroglycerin Hibitane chlorhexidine
Goodnight promethazine HibMenCY meningococcal groups C & Y & Haemophilus B
Gopten trandolapril tetanus toxoid conjugate vaccine
Goutnil colchicine HibTITER Hemophilus B vaccine
Gralise gabapentin Histantil promethazine
grass marihuana Hitrin terazosin
Green-Alpha interferon alfa Hivid zalcitabine
Hizentra immune globulin sc Imitrex sumatriptan

Holoxan ifosfamide Imlygic talimogene laherparepvec
Horizant gabapentin Imodium loperamide
HPV4 human papillomavirus (HPV) vaccine Imossel loperamide
Huberplex chlordiazepoxide Imovane eszopiclone
Humagel paromomycin Imovax influenza vaccine
Humatin paromomycin Implanta cyclosporine
Humira adalimumab Impril imipramine
Hyalgan hyaluronic acid Imuprin azathioprine
hyaluronidase hyaluronic acid Imuran azathioprine
Hybloc labetalol Imurek azathioprine
Hycamtin topotecan Imurel azathioprine
Hyco hyoscyamine Inapsin droperidol
Hycosol Sl hyoscyamine Inapsine droperidol
Hycotuss hydrocodone Incivek telaprevir
Hydeltrasol prednisolone Incruse umeclidinium
Hydopa methyldopa Inderal LA propranolol
Hydrea hydroxyurea Inderal propranolol
Hydrogen fluoride [HF] fluorides Inderide hydrochlorothiazide
Hydromet hydrocodone Indochron indomethacin
Hydrosaluric hydrochlorothiazide Indocin indomethacin
HydroStat IR hydromorphone Indolar SR indomethacin
hydroxycarbamide hydroxyurea indometacin indomethacin
hydroxydaunomycin doxorubicin Indotec indomethacin
Hylaform hyaluronic acid Inegy simvastatin
Hylan G-F 20 hyaluronic acid INF interferon alfa
Hylutin progestins Infergen interferon alfa
Hynorex Retard lithium Inflamase prednisolone
Hyospaz hyoscyamine Inflectra infliximab
Hypolar nifedipine Inflexal V influenza vaccine
Hysingla ER hydrocodone Influsome influenza vaccine
Hytrin terazosin Infumorph morphine
Hytrine terazosin Infurin nitrofurantoin
Hytrinex terazosin Ingrezza valbenazine
Hyzaar hydrochlorothiazide, losartan INH isoniazid
Inhibitron omeprazole
I Inlyta axitinib
IB-Stat hyoscyamine Innofem estradiol
ibandronic acid ibandronate Innohep tinzaparin
Ibrance palbociclib Innopran XL propranolol
Idamycin idarubicin Innovace enalapril
Idhifa enasidenib Insomnal diphenhydramine
Idotrim trimethoprim Integrex reboxetine
Ifex ifosfamide Integrilin eptifibatide
IFN interferon alfa Intelence etravirine
Ifoxan ifosfamide Intercon oral contraceptives
IG Gamma immune globulin IV Interglobin immune globulin IV
IGIM immune globulin IV interleukin-2 aldesleukin
IGIV immune globulin IV Intrarosa prasterone
Iktorivil clonazepam Intron A interferon alfa
IL-2 aldesleukin Introna interferon alfa
Ilaris canakinumab Introne interferon alfa
Ilosone erythromycin Intropin dopamine
Ilotycin erythromycin Invanz ertapenem
Imbrilon indomethacin Invega paliperidone
Imbruvica ibrutinib Invirase saquinavir
Imdur isosorbide mononitrate Invivac influenza vaccine
Imfinzi durvalumab Invokamet canagliflozin, metformin
Imidol imipramine Invokana canagliflozin
Imigran sumatriptan Ionamin phentermine
Imipramin imipramine Iopidine apraclonidine
Ipamix indapamide Kadcyla ado-trastuzumab emtansine

Ipolab labetalol Kadian morphine
Ipral trimethoprim Kalcide praziquantel
Ipratropium Steri-Neb ipratropium Kaletra lopinavir, ritonavir
Iquix levofloxacin Kalium potassium iodide
Iremofar hydroxyzine Kallmiren buspirone
Irenor reboxetine Kalma alprazolam
Iressa gefitinib Kalten atenolol
Isavuconazole isavuconazonium sulfate Kaluril amiloride
Isentress raltegravir Kalydeco ivacaftor
Ismipur mercaptopurine Kanamicina kanamycin
Ismo isosorbide mononitrate Kanamycine kanamycin
Ismotic isosorbide Kanamytrex kanamycin
Isobac co-trimoxazole Kanbine amikacin
Isoptin verapamil Kanescin kanamycin
Isoptine verapamil Kannasyn kanamycin
Isopto Atropine atropine sulfate Kantrex kanamycin
Isopto Eserine physostigmine Kanuma sebelipase alfa
Isopto Pilocarpine pilocarpine Kaywan phytonadione
Isopto-Epinal epinephrine Kcentra prothrombin complex concentrate (human)
Isopto atropine sulfate Keduril ketoprofen
Isordil isosorbide dinitrate Kefarol cephalexin
Isorythm disopyramide Keflex cephalexin
Isotamine isoniazid Kefolor cefaclor
Isotrex isotretinoin Keftab cephalexin
Isox itraconazole Kelac ketorolac
Isozid isoniazid Kelatin penicillamine
Istin amlodipine Kenaprol metoprolol
Istodax romidepsin Kengreal cangrelor
Istubol tamoxifen Kenzoflex ciprofloxacin
Italnik ciprofloxacin Kepivance palifermin
Itranax itraconazole Keppra levetiracetam
Itrin terazosin Kerlon betaxolol
IV Globulin-S immune globulin IV Kerlone betaxolol
Iveegam immune globulin IV Kerydin tavaborole
IVIG immune globulin IV Kessar tamoxifen
Ixiaro Japanese encepahlitis vaccine Ketalar ketamine
Izba travoprost Ketalin ketamine
Ketanest ketamine
J Ketoderm
Ketoisidin
ketoconazole
ketoconazole
Jacutin lindane
Ketolar ketamine
Jadelle levonorgestrel
Ketonic ketorolac
Jadenu deferasirox
Kevadon thalidomide
Jalyn dutasteride, tamsulosin
Kevzara sarilumab
Janumet metformin, sitagliptin
Keytruda pembrolizumab
Januvia sitagliptin
Khedezla desvenlafaxine
Jardiance empagliflozin
KI potassium iodide
Jenamicin gentamicin
Kidrolase asparaginase
Jetrea ocriplasmin
Kie potassium iodide
Jezil gemfibrozil
Kildane lindane
Jodatum potassium iodide
Kineret anakinra
Jodid potassium iodide
Kinidin quinidine
Jublia efinaconazole Kisqali ribociclib
Jumex selegiline Klacid clarithromycin
Jurnista hydromorphone Klaricid clarithromycin
Juvederm hyaluronic acid Klexane enoxaparin
Juxtapid lomitapide Klonopin clonazepam
Kloramfenicol chloramphenicol
K Klozapol clozapine
Kabikinase streptokinase Kodapan carbamazepine
Koffex dextromethorphan Lenal temazepam

Kolkicin colchicine Lencid lindane
Konakion phytonadione Lenoxin digoxin
Konicine colchicine Lentizol amitriptyline
Korec quinapril Lentorsil ursodiol
Korlym mifepristone Lenvima lenvatinib
Kovaltry antihemophilic factor Leponex clozapine
Kovanaze tetracaine & oxymetazoline Leptanal fentanyl
KP-E dinoprostone Leptopsique perphenazine
Kredex carvedilol Lescol fluvastatin
Krenosin adenosine Letairis ambrisentan
Krenosine adenosine Leucovorin leucovorin
Kripton bromocriptine Leukerin mercaptopurine
Krystexxa pegloticase Leukosulfan busulfan
Kwell lindane Leunase asparaginase
Kwildane lindane Leuprorelin leuprolide
Kybella deoxycholic acid Leustatin cladribine
Kyleena levonorgestrel Levanxene temazepam
Kyprolis carfilzomib Levaquin levofloxacin
Levate amitriptyline
L Levbid
Levemir
hyoscyamine
insulin detemir
L-asparaginase asparaginase
L-Cysteine acetylcysteine Levitra vardenafil
L-deprenyl selegiline Levlen oral contraceptives
L-dopa levodopa Levlite oral contraceptives
L-DOPS droxidopa Levo-T levothyroxine
L-Gent gentamicin Levodopa-Woelm levodopa
L-Polamidon methadone Levora oral contraceptives
L-thyroxine sodium levothyroxine Levothyroid levothyroxine
Labrocol labetalol Levothyrox levothyroxine
Ladogal danazol Levoxyl levothyroxine
Lagaquin chloroquine Levsin/SL hyoscyamine
lambrolizumab pembrolizumab Levsin hyoscyamine
Lamictal lamotrigine Levsinex hyoscyamine
Lamisil terbinafine Levulan Kerastick aminolevulinic acid
Lamocot diphenoxylate Lexapro escitalopram
Landsen clonazepam Lexin carbamazepine
Lanicor digoxin Lexinor norfloxacin
Lanoxin digoxin Lexiva fosamprenavir
Lantarel methotrexate Lexpec folic acid
Lantus insulin glargine Lexxel enalapril
Lapole flurbiprofen Lialda mesalamine
Laraflex naproxen Libritabs chlordiazepoxide
Larapam piroxicam Librium chlordiazepoxide
Largactil chlorpromazine Lidaprim trimethoprim
Lariam mefloquine Lidifen ibuprofen
Laricam mefloquine Lidodan lidocaine
Laroferon interferon alfa Lidoderm lidocaine
Laroxyl amitriptyline Lidoject-2 lidocaine
Lartruvo olaratumab Lifaton B12 cyanocobalamin
Lasilix furosemide lignocaine lidocaine
Lasix furosemide Likudin M griseofulvin
Laspar asparaginase Limbitrol amitriptyline, chlordiazepoxide
Lastet etoposide Lin-Amnox amoxicillin
Latisse bimatoprost Lincocin lincomycin
Latuda lurasidone Lincocine lincomycin
Laubeel lorazepam Linzess linaclotide
Lebic baclofen Liocarpina pilocarpine
Lederfolin leucovorin Lioresal baclofen
Ledertrexate methotrexate Lipex simvastatin
Ledoxina cyclophosphamide Lipitor atorvastatin
Liponorm simvastatin Low-Quel diphenoxylate

Lipostat pravastatin Loxapac loxapine
Liptruzet atorvastatin, ezetimibe Loxen nicardipine
Lipur gemfibrozil Loxitane loxapine
Liquemin heparin Lozapin clozapine
Liquiprin acetaminophen Lozide indapamide
Liroken diclofenac Lozol indapamide
Lisino loratadine Lucassin terlipressin
Lismol cholestyramine Lucentis ranibizumab
Litalir hydroxyurea Lucrin leuprolide
Litanin ursodiol Lugol’s solution potassium iodide
Lithicarb lithium Lukadin amikacin
Lithizine lithium Lumigan bimatoprost
Lithobid lithium Luminal phenobarbital
Lithonate lithium Luminaletten phenobarbital
Lithotabs lithium Lunelle medroxyprogesterone, oral contraceptives
Litocure ursodiol Lunesta eszopiclone
Litoff ursodiol Lupron Depot-Ped leuprolide
Litursol ursodiol Lupron leuprolide
Livalo pitavastatin Lustra hydroquinone
Lo/Ovral oral contraceptives Luvox fluvoxamine
Locion-V lindane Luzu luliconazole
Locol fluvastatin Lyeton ursodiol
Lodales simvastatin Lynparza olaparib
Lodimol dipyridamole Lyovac dactinomycin
Lodine etodolac Lyple alprostadil
Lodosyn carbidopa Lyrica pregabalin
Loestrin oral contraceptives Lyrinel oxybutynin
Lofene atropine sulfate, diphenoxylate Lysalgo mefenamic acid
Logastric omeprazole Lysatec rt-PA alteplase
Logen atropine sulfate, diphenoxylate Lyxumia lixisenatide
Lomaira phentermine
Lomanate atropine sulfate, diphenoxylate M
Lomarin dimenhydrinate M-KYA quinine
Lomir SRO isradipine M-M-R II measles, mumps & rubella (MMR) virus vaccine
Lomir isradipine Maalox Anti-Diarrheal loperamide
Lomotil atropine sulfate, diphenoxylate Maalox loperamide
Lomper mebendazole MabCampath alemtuzumab
Lonazep clonazepam Mablin busulfan
Lonine etodolac MabThera rituximab
Loniten minoxidil Macladin clarithromycin
Lonolox minoxidil Macrobid nitrofurantoin
Lonoten minoxidil Macrodantin nitrofurantoin
Lonox diphenoxylate Macugen pegaptanib
Lonsurf trifluridine & tipiracil Malarivon chloroquine
Lop-Dia loperamide Malarone atovaquone/proguanil
Loperhoe loperamide Malocide pyrimethamine, sulfadoxine
Lopid gemfibrozil Maloprim dapsone
Lopirin captopril Mamofen tamoxifen
Lopressor hydrochlorothiazide, metoprolol Mapap acetaminophen
Lopril captopril Marax ephedrine, hydroxyzine
Lorastine loratadine Marcillin ampicillin
Lorcet acetaminophen Mareen doxepin
Lorexane lindane Marevan warfarin
Lortab hydrocodone marijuana marihuana
Losec omeprazole Marinol dronabinol
Lotensin HCT benazepril, hydrochlorothiazide Marmine dimenhydrinate
Lotensin benazepril, hydrochlorothiazide Marthritic salsalate
Lotrel amlodipine, benazepril Masmoran hydroxyzine
Lovalip lovastatin Maveral fluvoxamine
Lovenox enoxaparin Mavik trandolapril
Mavyret glecaprevir & pibrentasvir Metrolotion metronidazole

Maxalt rizatriptan Metrolyl metronidazole
Maxcef cefepime Mevacor lovastatin
Maxidone hydrocodone Meval diazepam
Maxiphed pseudoephedrine Mevinacor lovastatin
Maxipime cefepime Mevinolin lovastatin
Maxitrol neomycin Miacalcic calcitonin
Maxtrex methotrexate Miacalcin calcitonin
Maxzide hydrochlorothiazide, triamterene Miacin amikacin
Mazepine carbamazepine Miaquin amodiaquine
Measurin aspirin Micardis hydrochlorothiazide, telmisartan
Mebensole mebendazole Micotef miconazole
Med-Glibe glyburide Micronase glyburide
Medamor amiloride Micronor progestins
Medianox chloral hydrate Microzide hydrochlorothiazide
MedihalerEpi epinephrine Midamor amiloride
Medilium chlordiazepoxide Midol 220 ibuprofen
Medimet methyldopa Midoride amiloride
Medipren ibuprofen Mifeprex mifepristone
Medispaz hyoscyamine Miglucan glyburide
Medrol methylprednisolone Mindiab glipizide
Mefac mefenamic acid Mindol mebendazole
Mefic mefenamic acid Minidiab glipizide
Megace progestins Miniprostin E(2) dinoprostone
Megacillin penicillin G Minirin desmopressin
Mekinist trametinib Minitran nitroglycerin
Meladinine methoxsalen Minobese-Forte phentermine
Melizide glipizide Minocin minocycline
Menabol stanozolol Minoclir 50 minocycline
Menhibrix meningococcal groups C & Y & Haemophilus B Minodiab glipizide
tetanus toxoid conjugate vaccine Minogalen minocycline
Menostar estradiol Minomycin minocycline
mepacrine quinacrine Minoximen minoxidil
Mephaquin mefloquine Minprog alprostadil
Mephaquine mefloquine Minurin desmopressin
Mephenon methadone Miocarpine pilocarpine
Mephyton phytonadione Miracol miconazole
Merabis spironolactone Mirapex pramipexole
Merlit lorazepam Mircette oral contraceptives
Meronem meropenem Mirena levonorgestrel
Merrem IV meropenem Mirvaso brimonidine
mesalazine mesalamine Misulban busulfan
Mesasal mesalamine mitomycin-C mitomycin
Mestacine minocycline Mitomycin mitomycin
Mestatin nystatin Mitomycine mitomycin
Mestinon pyridostigmine Mitoxana ifosfamide
Metadate CD methylphenidate Mitran chlordiazepoxide
Metadon methadone Mobic meloxicam
Metaglip glipizide, metformin Mobilin sulindac
Metandren methyltestosterone Modamide amiloride
Metex methotrexate Modecate fluphenazine
Metforal metformin Modicon oral contraceptives
Methadose methadone Moditen fluphenazine
Methipox sulfadoxine Moduretic amiloride, hydrochlorothiazide
Methoprim trimethoprim Molelant cefotaxime
Methylin methylphenidate Molipaxin trazodone
methylmorphine codeine molly MDMA
Meticorten prednisone Monazole-7 miconazole
Metomin metformin Monistat miconazole
Metrocream metronidazole Mono-Gesic salsalate
MetroGel metronidazole Monocor bisoprolol
Monodox doxycycline Myolax carisoprodol

Monoflam diclofenac Myrbetriq mirabegron
Monofluorophosphate [MFP] fluorides
Monoket
Mononate
isosorbide mononitrate
artesunate
N
N-acetyl-glucosamine (NAG) glucosamine
Monopril fosinopril N-acetylcysteine acetylcysteine
Monotrim trimethoprim Nabuser nabumetone
Mopral omeprazole NAC acetylcysteine
Morcomine hydrocodone Nadic nadolol
Moronal nystatin Nalcryn SP nalbuphine
Morphabond morphine Nalorex naltrexone
Morphine-HP morphine Nalpin naloxone
MOS morphine Namenda memantine
Moscontin morphine Naplin indapamide
Motiax famotidine Naprelan naproxen
Motifene diclofenac Naprogesic naproxen
Motrin ibuprofen Napron X naproxen
Movantik naloxegol Naprosyn naproxen
Movergan selegiline Naprosyne naproxen
Moxacef cefadroxil Narcan naloxone
Moxeza moxifloxacin Narcanti naloxone
MS Contin morphine Narcotan naloxone
MS-IR morphine Narilet aldesleukin
MS/S morphine Narol buspirone
MSIR Oral morphine Nascobal cyanocobalamin
MST Continus morphine Natesto testosterone
MTC mitomycin Natrilix indapamide
MTX methotrexate Nauseatol dimenhydrinate
Mucofillin acetylcysteine Nausicalm dimenhydrinate
Mucolit acetylcysteine Navelbine vinorelbine
Mucolitico acetylcysteine Naxen naproxen
Mucoloid acetylcysteine Nazoltec ketoconazole
Mucomiste acetylcysteine Nebilet nebivolol
Mucomyst-10 acetylcysteine NebuPent pentamidine
Mucomyst acetylcysteine Necon oral contraceptives
Mucosil-10 acetylcysteine NEE oral contraceptives
Multaq dronedarone Nelova oral contraceptives
Multipax hydroxyzine Nemasol mebendazole
Multum chlordiazepoxide Nemexin naltrexone
Murelax oxazepam Neo-Synephrine phenylephrine
Muse alprostadil Neomicina neomycin
Mustargen mechlorethamine Neomycine Diamant neomycin
Mustine Hydrochloride Boots mechlorethamine Neopap acetaminophen
mustine mechlorethamine Neoral cyclosporine
Mutamycin mitomycin Neosar cyclophosphamide
Myambutol ethambutol Neosporin neomycin
Mycamine micafungin Neosulf neomycin
Myciguent neomycin Neotigason acitretin
Mycobax BCG vaccine NEPA netupitant & palonosetron
Mycobutin rifabutin Nephronex nitrofurantoin
Mycol metoprolol Nergadan lovastatin
Mycology-II nystatin Nerlynx neratinib
mycophenolate mofetil, mycophenolate sodium mycophenolate Nesina alogliptin
Mycostatin nystatin Neupro rotigotine
Mydayis dextroamphetamine Neurap pimozide
Myfortic mycophenolate Neurobloc botulinum toxin (A & B)
Mylanta AR famotidine Neurontin gabapentin
Myleran busulfan Neurosine buspirone
Mylocel hydroxyurea Nexavar sorafenib
Mynocine minocycline Nexiclon clonidine
Myobloc botulinum toxin (A & B) Nexium esomeprazole
Nia-Bid niacin Norfenon propafenone

Niac niacin Norgesic aspirin
Niacels niacin Norinyl oral contraceptives
Niacinamide niacinamide Noritate metronidazole
Niacor niacin Noritren nortriptyline
Niaspan niacin Norlutate progestins
Nicabate nicotine Norlutin progestins
Nicardal nicardipine Normison temazepam
Nico-Vert dimenhydrinate Normorytmin propafenone
Nicobid niacin Normozide labetalol
Nicobion niacin Noroxin norfloxacin
Nicodel nicardipine Norpace disopyramide
Nicoderm nicotine Norphyl aminophylline
Nicolan nicotine Norplant levonorgestrel
Nicorette Plus nicotine Norpress nortriptyline
Nicorette nicotine Northera droxidopa
Nicotibine isoniazid Nortrilen nortriptyline
nicotinamide niacinamide Norvas amlodipine
Nicotinell-TTS nicotine Norvasc amlodipine
Nicotinex niacin Norvir ritonavir
nicotinic acid niacin Noten atenolol
Nicotrans nicotine Novahistine DH codeine
Nicotrol nicotine Novahistine phenylephrine
Nicovital niacin Novamin prochlorperazine
Nicozid isoniazid Novamoxin amoxicillin
Nida Gel metronidazole Novantrone mitoxantrone
Nifecor nifedipine Novapen-VK penicillin V
Nifedipress nifedipine Novasen aspirin
Nikofrenon nicotine Novazam diazepam
Ninlaro ixazomib Novitropan oxybutynin
Niotal zolpidem Novo-Atenol atenolol
Nirulid amiloride Novo-AZT zidovudine
Nistaquim nystatin Novo-Chlorpromazine chlorpromazine
Nitro-Dur nitroglycerin Novo-Cycloprine cyclobenzaprine
NitroBid nitroglycerin Novo-Digoxin digoxin
Nitrocap nitroglycerin Novo-Dipiradol dipyridamole
Nitrocine nitroglycerin Novo-Doxepin doxepin
Nitrodur nitroglycerin Novo-Doxylin doxycycline
nitrogen mustard mechlorethamine Novo-Flutamide flutamide
Nitroglin nitroglycerin Novo-Furan nitrofurantoin
nitroglycerol nitroglycerin Novo-Hylazin hydralazine
Nitrolingual nitroglycerin Novo-Ipramide ipratropium
Nitromist nitroglycerin Novo-Keto ketoprofen
Nitronal nitroglycerin Novo-Lexin cephalexin
Nitrospan nitroglycerin Novo-Medrone medroxyprogesterone
Nitrostat nitroglycerin Novo-Metformin metformin
Nitrumon carmustine Novo-Naprox naproxen
Nivemycin neomycin Novo-Pramine imipramine
Nizoral ketoconazole Novo-Purol allopurinol
Nobegyl salsalate Novo-Selegiline selegiline
Nocbin disulfiram Novo-Semide furosemide
Noctec chloral hydrate Novo-Spiroton spironolactone
Noctiva desmopressin Novo-Sundac sulindac
Nodine ketorolac Novo-Zolamide acetazolamide
Nolvadex tamoxifen Novochlorhydrate chloral hydrate
Nor-QD progestins Novocimetine cimetidine
Norboral glyburide Novoclopate clorazepate
Norco hydrocodone Novofen tamoxifen
Nordette oral contraceptives NovoLog insulin aspart
Norebox reboxetine Novomit prochlorperazine
Norethin oral contraceptives Novopen-G penicillin G
Novopoxide chlordiazepoxide Oflocet ofloxacin

NovoRapid insulin aspart Oflocin ofloxacin
Novotriptyn amitriptyline Oforta fludarabine
Novoxapam oxazepam Oftalmotrisol-T tobramycin
Noxafil posaconazole Oleomycetin chloramphenicol
NTG nitroglycerin Oleptro trazodone
Nu-Alprax alprazolam Olmetec olmesartan
Nu-Amoxi amoxicillin Olysio simeprevir
Nu-Atenol atenolol Omed omeprazole
Nu-Baclo baclofen Omnicef cefdinir
Nu-Buspirone buspirone OmniHIB Hemophilus B vaccine
Nu-Capto captopril OMS Oral morphine
Nu-Cimet cimetidine Onbrez Breezhaler indacaterol
Nu-Clonidine clonidine Oncaspar pegaspargase
Nu-Diclo diclofenac Onco-Carbide hydroxyurea
Nu-Diltiaz diltiazem Oncocarbin carboplatin
Nu-Doxycycline doxycycline Oncoden ondansetron
Nu-Famotidine famotidine oncovin vincristine
Nu-Flurprofen flurbiprofen Onglyza saxagliptin
Nu-Gemfibrozil gemfibrozil Onicit palonosetron
Nu-Hydral hydralazine Onivyde irinotecan
Nu-Indo indomethacin Onmel itraconazole
Nu-Loraz lorazepam Onzetra Xsail sumatriptan
Nu-Medopa methyldopa Opana oxymorphone
Nu-Naprox naproxen Opdivo nivolumab
Nu-Nifed nifedipine Ophthochlor chloramphenicol
Nu-Pirox piroxicam Opistan meperidine
Nu-Ranit ranitidine Opizone naltrexone
Nu-Temazepam temazepam Opsumit macitentan
Nu-Verap verapamil Optenyl papaverine
Nubain SP nalbuphine Optipres betaxolol
Nubain nalbuphine Optovit-E vitamin E
Nucala mepolizumab Oracea doxycycline
Nucofed codeine Oracefal cefadroxil
Nucynta ER tapentadol Oramorph SR morphine
Nucynta tapentadol Oranor norfloxacin
Nulev hyoscyamine Oranyst nystatin
Nulojix belatacept Orap pimozide
Nuplazid pimavanserin Oravig miconazole
Nuprin ibuprofen Orbactiv oritavancin
Nuvigil armodafinil Orencia abatacept
Nyaderm nystatin Orientomycin cycloserine
Nystacid nystatin Oritaxim cefotaxime
Nystan nystatin Orkambi lumacaftor/ivacaftor
Nystex nystatin Ormazine chlorpromazine
Nytol diphenhydramine Ornade chlorpheniramine
Ornidyl eflornithine
O Oroken cefixime
Ocaliva obeticholic acid Ortho Tri-Cyclen oral contraceptives
Ocrevus ocrelizumab Ortho-Cept oral contraceptives
Octagam immune globulin IV Ortho-Cyclen oral contraceptives
Octocaine lidocaine Ortho-Novum oral contraceptives
Octostim desmopressin Orthovisc hyaluronic acid
Ocuflox ofloxacin Orudis ketoprofen
Ocumycin gentamicin Oruvail ketoprofen
Ocusert Pilo pilocarpine Osiren spironolactone
Odefsey emtricitabine/rilpivirine/tenofovir alafenamide Ospen penicillin V
Odomzo sonidegib Ospexin cephalexin
Odrik trandolapril Osphena ospemifene
Ofev nintedanib Osteum etidronate
Ofirmev acetaminophen Otarex hydroxyzine
Otezla apremilast Paveral codeine

Otrexup methotrexate Paxene paclitaxel
Otrivine xylometazoline Paxil CR paroxetine hydrochloride
Ovcon oral contraceptives Paxil paroxetine hydrochloride
Ovral oral contraceptives Paxistil hydroxyzine
Ovrette progestins Paxtibi nortriptyline
Oxiklorin hydroxychloroquine PCC prothrombin complex concentrate (human)
Oxpam oxazepam PCE erythromycin
Oxsoralen methoxsalen, psoralens PCV pneumococcal vaccine
Oxsoralon methoxsalen Pedi-Dri nystatin
Oxtellar XR oxcarbazepine Pediapred prednisolone
Oxyban oxybutynin Pediatrix hepatitis B vaccine
Oxybutyn oxybutynin Pediazole erythromycin
OxyContin oxycodone PedivaxHIB Hemophilus B vaccine
Oxydess dextroamphetamine Pegasys PEG-interferon
OxyIR oxycodone PegIntron PEG-interferon
Oxytrol oxybutynin Penbeta penicillin V
Ozoken omeprazole Penbritin ampicillin
Ozurdex dexamethasone Pendramine penicillamine
Pennsaid diclofenac
P Penstabil
Pentacarinat
ampicillin
pentamidine
Pacerone amiodarone
Pacifen baclofen Pentaglobin immune globulin IV
Paclimer paclitaxel Pentam 300 pentamidine
Palaron aminophylline Pentamycetin chloramphenicol
Palexia tapentadol Pentasa SR mesalamine
Palladone hydromorphone Pentasa mesalamine
Palmitate A vitamin A Pentazine promethazine
Palux alprostadil Pentoxi pentoxifylline
Pameion papaverine Pentoxil pentoxifylline
Pamelor nortriptyline Pepcid famotidine
Pamid indapamide Pepcidine famotidine
Pamprin ibuprofen Pepdul famotidine
Panadol acetaminophen Pepeom Amide niacin
Panbesy phentermine Peptard hyoscyamine
Panbesyl phentermine Peptaron ursodiol
Pandemrix pandemic influenza vaccine (H1N1) Pepto-Bismol bismuth
Panglobulin immune globulin IV Peptol cimetidine
Panoral cefaclor Peratsin perphenazine
Panretin alitretinoin Percocet acetaminophen, oxycodone
Pantelmin mebendazole Percogesic acetaminophen
Panuric probenecid Perforomist formoterol
Papaverine 60 papaverine Peridex chlorhexidine
Papaverini papaverine Peridol haloperidol
paracetamol acetaminophen PerioChip chlorhexidine
Paraplatin carboplatin Periogard chlorhexidine
Paraplatine carboplatin Periostat doxycycline
Parilac bromocriptine Perlane hyaluronic acid
Parizac omeprazole Perlutex medroxyprogesterone
Parkemed mefenamic acid Perphenan perphenazine
Parlodel bromocriptine Persantin dipyridamole
Parsabiv etelcalcetide Persantine dipyridamole
Parvolex acetylcysteine Pertussin dextromethorphan
Pasmex hyoscyamine Petar ketamine
Pasotomin prochlorperazine pethidine meperidine
Pataday olopatadine Petidin meperidine
Patanol olopatadine Petnidan ethosuximide
Pavabid papaverine Pexal pentoxifylline
Pavagen papaverine PGE alprostadil
Pavased papaverine Phenaemal phenobarbital
Pavatine papaverine Phenaphen acetaminophen
Phenazine promethazine Pradaxa dabigatran

Phenergan promethazine Praluent alirocumab
Phenetron chlorpheniramine Prandin E2 dinoprostone
Phenhydan phenytoin Pravachol pravastatin
phenobarbitone phenobarbital Pravasin pravastatin
Phenoxymethylpenicillin penicillin V Pravasine pravastatin
phenylethylmalonylurea phenobarbital Pravidel bromocriptine
Phenytek phenytoin Praxbind idarucizumab
phenytoin sodium phenytoin Praxiten oxazepam
Pheryl-E vitamin E Prazite praziquantel
Phyllocontin aminophylline Pre-Par ritodrine
Phyllotemp aminophylline Precaptil captopril
Phytomenadione phytonadione Precose acarbose
Picato ingenol mebutate Pred-G gentamicin
Pidilat nifedipine Prefrin Liquifilm phenylephrine
Pilo Grin pilocarpine Prelone prednisolone
Pilogel pilocarpine Premphase medroxyprogesterone
Pilopine pilocarpine Prempro medroxyprogesterone
Pilopt pilocarpine Prepidil dinoprostone
Pimodac pimozide Pres enalapril
Pink Bismuth bismuth Prescal isradipine
Pirimecidan pyrimethamine Presinol methyldopa
Pitocin oxytocin Presoken diltiazem
Pitressin vasopressin Presolol labetalol
Placil clomipramine Prestalia amlodipine, perindopril
Plan B levonorgestrel Pretz-D ephedrine
Planphylline aminophylline Prevacid lansoprazole
Planum temazepam Prevalite cholestyramine
Plaquenil hydroxychloroquine Preveon adefovir
Plaquinol hydroxychloroquine Prevnar pneumococcal vaccine
Plasmotrim artesunate Prevpac amoxicillin
Plasticin cisplatin Prexum perindopril
Platiblastin cisplatin Prezcobix darunavir
Platinex cisplatin Prezista darunavir
Platinol-AQ cisplatin Priadel lithium
Platinol cisplatin Prialt ziconotide
Platistil cisplatin Pridemon tranexamic acid
Plavix clopidogrel Prilosec omeprazole
Plegridy interferon beta Primacor milrinone
Pletal cilostazol Primafen cefotaxime
Plurimen selegiline Primatene Mist epinephrine
PMS-Baclofen baclofen Primatene epinephrine
PMS-Cholestyramine cholestyramine Primiprost dinoprostone
PMS-Isoniazid isoniazid Primonil imipramine
PMS-Lindane lindane Primosept trimethoprim
PncOMP pneumococcal vaccine Primsol trimethoprim
Pneumovax II pneumococcal vaccine Principen ampicillin
Pnu-Immune pneumococcal vaccine Princol lincomycin
Polinal methyldopa Prinil lisinopril
Poly-Pred neomycin Prinivil lisinopril
Polygam S/D immune globulin IV Prinzide hydrochlorothiazide, lisinopril
Polygris griseofulvin Pristiq desvenlafaxine
Polytrim trimethoprim Pro-Amox amoxicillin
Pomalyst pomalidomide Pro-Ampi ampicillin
Ponstan mefenamic acid Pro-Cure finasteride
Ponstel mefenamic acid Pro-Depo progestins
Ponstyl mefenamic acid Pro-Trin co-trimoxazole
Portrazza necitumumab Probalan probenecid
pot marihuana Probuphine buprenorphine
Potiga ezogabine Procan SR procainamide
PPV pneumococcal vaccine Procan procainamide
Procanbid procainamide Purinethol mercaptopurine

Procardia nifedipine Purinol allopurinol
Procid probenecid Puvasoralen methoxsalen
Procoralan ivabradine Pyknolepsinum ethosuximide
Procren Depot leuprolide Pyoredol phenytoin
Procrin leuprolide Pyrethia promethazine
Procrit epoetin alfa
Procytox
Prodac
cyclophosphamide
nabumetone
Q
Q-Vel quinine
Prodopa methyldopa
Qnasl beclomethasone
Prodox progestins
Qsymia phentermine, topiramate
Profen ibuprofen
Qtern dapagliflozin, saxagliptin
Proflex ibuprofen
Qualaquin quinine
Progestaject progestins
Quantalan cholestyramine
Progevera medroxyprogesterone
Qudexy topiramate
Prograf tacrolimus
Quellada lindane
ProHIBIT Hemophilus B vaccine
Quensyl hydroxychloroquine
Prolaken metoprolol
Querto carvedilol
Proleukin aldesleukin
Questran Lite cholestyramine
Prolex-D phenylephrine
Questran cholestyramine
Prolex-DH hydrocodone
Quibron aminophylline
Prolia denosumab
Quiess hydroxyzine
Prolift reboxetine
Quinalan quinidine
Prolixin fluphenazine
Quinate quinidine
Promacta eltrombopag
Quinazil quinapril
Prometh-50 promethazine
Quini Durules quinidine
Promine procainamide
Quinoctal quinine
Pronestyl procainamide
Quinora quinidine
Propachem hydrocodone
Quinsan quinine
Propaphenin chlorpromazine
Quinsul quinine
Propecia finasteride
Quintasa mesalamine
Propess dinoprostone
Quiphile quinine
Prorazin prochlorperazine
Quixin levofloxacin
Proscar 5 finasteride
Qvar beclomethasone
Proscar finasteride
prostaglandin E1 alprostadil
Prostaphlin oxacillin R
Prostarmon dinoprostone Ra-223 dichloride radium-223 dichloride
Prostigmin neostigmine Radicava edaravone
Prostin E2 dinoprostone Radiesse calcium hydroxylapatite
Prostin VR alprostadil, dinoprostone Ralovera medroxyprogesterone
Prostin dinoprostone Ralozam alprazolam
Prostine VR alprostadil Ramicin rifampin
Prostine dinoprostone Randikan kanamycin
Prostivas alprostadil Ranexa ranolazine
Prothiazine promethazine Raniben ranitidine
Protium pantoprazole Raniplex ranitidine
Protogen dapsone Ranisen ranitidine
Protonix pantoprazole Ranvil nicardipine
Protopam pralidoxime Rapaflo silodosin
Protopic tacrolimus Rapamune sirolimus
Proventil albuterol rapamycin sirolimus
Provera medroxyprogesterone, progestins Rapivab peramivir
Provigil modafinil Rasuvo methotrexate
Prozac fluoxetine Rayaldee calcifediol
Prozin chlorpromazine Razadyne galantamine
Pryleugan imipramine Reactine cetirizine
Psicofar chlordiazepoxide Rebetol ribavirin
Pulmicort Turbuhaler budesonide Rebetron interferon alfa, ribavirin
Punktyl lorazepam Rebif interferon beta
Puri-Nethol mercaptopurine Reclast zoledronate
Recombivax HB hepatitis B vaccine Rhythmin procainamide

Rectiv nitroglycerin Ride amiloride
Redisol cyanocobalamin Ridene nicardipine
Redusa phentermine Rifadin rifampin
Refobacin gentamicin Rifaldin rifampin
Refolinin leucovorin Rifamate isoniazid
Refusal disulfiram Rifamed rifampin
Regaine minoxidil rifampicin rifampin
Regitin phentolamine Rifater isoniazid
Regitine phentolamine Rilatine methylphenidate
Regonol pyridostigmine Rimactane rifampin
Relafen nabumetone Rimpin rifampin
Relenza zanamivir Rimycin rifampin
Relief tretinoin Rinatec ipratropium
Relif nabumetone Riomet metformin
Relifex nabumetone Risperdal Consta risperidone
Relpax eletriptan Risperdal risperidone
Remeron mirtazapine Ritalin methylphenidate
Remethan diclofenac Ritmocamid procainamide
Remicade infliximab Ritmolol metoprolol
Reminyl galantamine Rituxan rituximab
Renflexis infliximab Rivotril clonazepam
Renitec enalapril RMS morphine
Reniten enalapril Roaccutan isotretinoin
Renova tretinoin Roaccutane isotretinoin
Repatha evolocumab Roacutan isotretinoin
Reposans-10 chlordiazepoxide Roacuttan isotretinoin
Requip ropinirole Robaxisal aspirin
Rescufolin leucovorin Robidrine pseudoephedrine
Rescuvolin leucovorin Robimycin erythromycin
Resmin diphenhydramine Robinul glycopyrrolate
Respirol terbutaline Robitussin AC codeine
Respontin ipratropium Robitussin-CF pseudoephedrine
Restasis cyclosporine Robitussin dextromethorphan
Restoril temazepam Rocefin ceftriaxone
Restylane Fine Lines hyaluronic acid Rocephalin ceftriaxone
retigabine ezogabine Rocephin ceftriaxone
Retin-A Micro tretinoin Roceron-A interferon alfa
Retinoic Acid tretinoin Rofact rifampin
Retinova tretinoin Roferon-A interferon alfa
Retrovir zidovudine Rogaine minoxidil
Revapole mebendazole Rogal piroxicam
Revatio sildenafil Rogitene phentolamine
ReVia naltrexone Rogitine phentolamine
Revimine dopamine Rotarix rotavirus vaccine
Reviten triamterene RotaTeq rotavirus vaccine
Revlimid lenalidomide Roubac co-trimoxazole
Revolade eltrombopag Rovacor lovastatin
Revonto dantrolene Rowasa mesalamine
Rexulti brexpiprazole Roxanol morphine
Reyataz atazanavir Roxicodone oxycodone
Rezine hydroxyzine Rozerem ramelteon
rFV111Fc antihemophilic factor Rtsun artesunate
Rheumatrex methotrexate Ru-Tuss hydrocodone
Rhinocort budesonide Rubesol-1000 cyanocobalamin
Rhodacine indomethacin Rubex doxorubicin
Rhodis ketoprofen rubidomycin daunorubicin
Rhofade oxymetazoline Rubifen methylphenidate
Rhonal aspirin Rubraca rucaparib
Rhotrimine trimipramine Rubramin cyanocobalamin
Rhovail ketoprofen Rufen ibuprofen
Ryanodex dantrolene Selectin pravastatin

Rybix ODT tramadol Selectol celiprolol
Rydapt midostaurin Selektine pravastatin
Rydene nicardipine Selipran pravastatin
Rynatan phenylephrine Seloken-Zok metoprolol
Rynatuss ephedrine Selozok metoprolol
Rytary levodopa Selzentry maraviroc
Rythmex propafenone Sendoxan cyclophosphamide
Rythmol propafenone Septra co-trimoxazole, sulfamethoxazole, trimethoprim
Rytmonorm propafenone Ser-Ap-Es hydralazine
Ryzodeg insulin aspart, insulin degludec Serax oxazepam
Serenace haloperidol
S Serepax
Serocryptin
oxazepam
bromocriptine
S-1 tegafur/gimeracil/oteracil
S-2 epinephrine Seromycin cycloserine
Sabril vigabatrin Seroquel quetiapine
Sacbexyl lindane Seroxat paroxetine hydrochloride
Saccharin saccharin Serozide etoposide
Saflutan tafluprost Sesamol flucloxacillin
Salagen pilocarpine Setamine hyoscyamine
salazopyrin sulfasalazine Sevredol morphine
Salbulin albuterol Sideril trazodone
salbutamol albuterol Sigacefal cefaclor
Salflex salsalate Sigafam famotidine
Salgesic salsalate Silenor doxepin
salicylazosulfapyridine sulfasalazine Silgard human papillomavirus (HPV) vaccine
Salina salsalate Silicofluoride fluorides
Salisulf sulfasalazine Siliq brodalumab
Salmagne labetalol Simatin ethosuximide
Salofalk mesalamine Simcor niacin, simvastatin
Sandimmun cyclosporine Simovil simvastatin
Sandimmune cyclosporine Simplene epinephrine
Sandoglobulin immune globulin IV Simponi golimumab
Sandoglobulina immune globulin IV Simulect basiliximab
Sandoglobuline immune globulin IV Sinaplin ampicillin
Sandostatin octreotide Sinemet levodopa
Sandostatina octreotide Singulair montelukast
Sandostatine octreotide Sinomin sulfamethoxazole
Sanoma carisoprodol Sinosid paromomycin
Sansert methysergide Sinquan doxepin
Saphris asenapine Sintodian droperidol
Sarafem fluoxetine Sinutab acetaminophen
Sarconyl lindane Siran acetylcysteine
Saridine sulfasalazine Sirdalud tizanidine
Saroten amitriptyline Sirtal carbamazepine
SAS-500 sulfasalazine Sirturo bedaquiline
Savaysa edoxaban Sitavig acyclovir
Savella milnacipran Sivastin simvastatin
Savlon chlorhexidine Sivextro tedizolid
Saxenda liraglutide Sizopin clozapine
Scabecid lindane Skelaxin metaxalone
Scabene lindane Sklice ivermectin
Scabex lindane Slo-Bid aminophylline
Scabi lindane Slo-Niacin niacin
Scabisan lindane SMX-TMP co-trimoxazole
SCIG immune globulin sc SMZ-TMP co-trimoxazole
Sebomin minocycline Sno Pilo pilocarpine
Sebvio telbivudine Sobelin clindamycin
Sedanazin gentamicin Sodium fluoride [NaF] fluorides
Sediat diphenhydramine Sodium monofluorophosphate fluorides
Seebri Neohaler glycopyrrolate Sodol carisoprodol
Solage tretinoin Starlix nateglinide

Solaraze Gel diclofenac Statex morphine
Solcodein codeine Steclin tetracycline
Solesorin hydralazine SteiVAA tretinoin
Solfoton phenobarbital Stelara ustekinumab
Solgol nadolol Stella prochlorperazine
Soliqua insulin glargine, lixisenatide Stemetil prochlorperazine
Soliris eculizumab Stendra avanafil
Solis diazepam Stieva-A tretinoin
Solium chlordiazepoxide Stilnoct zolpidem
Solodyn minocycline Stilnox zolpidem
Solosec secnidazole Stimate desmopressin
Solpurin probenecid Stiolto Respimat olodaterol, tiotropium
Solu-Medrol methylprednisolone Stomedine cimetidine
Solutrat ursodiol Stopit loperamide
Solvex reboxetine Storzine pilocarpine
Soma Compound aspirin Strattera atomoxetine
Soma carisoprodol Strensiq asfotase alfa
Somadril carisoprodol Streptase streptokinase
Somatuline Autogel lanreotide Streptomycin streptomycin
Somatuline Depot lanreotide Stribild cobicistat/elvitegravir/emtricitabine/tenofovir
Somatuline LA lanreotide disoproxil
Somavert pegvisomant Striverdi Respimat olodaterol
Sominex 2 diphenhydramine Stromba stanozolol
Somnox chloral hydrate Stromectol ivermectin
Somophyllin aminophylline Strumazol methimazole
Sonata zaleplon Stubit nicotine
Soolantra ivermectin Sublimaze fentanyl
Sopamycetin chloramphenicol Suboxone buprenorphine, naloxone
Sorbitrate isosorbide dinitrate Subutex buprenorphine
Soriatane acitretin Sucrabest sucralfate
Soridol carisoprodol Sucrets dextromethorphan
Sorine sotalol Sudafed pseudoephedrine
Sostril ranitidine Sular nisoldipine
Sotacor sotalol Sulcrate sucralfate
Sotahexal sotalol Sulene sulindac
Sotalex sotalol sulfamethoxazole-trimethoprim co-trimoxazole
Sotilen piroxicam Sulfatrim co-trimoxazole
Sotret isotretinoin Sulfazine sulfasalazine
Sovaldi sofosbuvir Sulfona dapsone
Spectro Gram chlorhexidine Sulfur hexafluoride [SF6] fluorides
Spersacarpine pilocarpine Sulic sulindac
Spinax baclofen Sulmidine clonidine
Spinraza nusinersen Suloril sulindac
Spiriva tiotropium Suloton triamterene
Spiroctan spironolactone Sumacef cefadroxil
Spirosine cefotaxime Sumavel DosePro sumatriptan
Splenda sucralose Sumontil trimipramine
Sporacid itraconazole Sumycin tetracycline
Sporal itraconazole Supartz hyaluronic acid
Sporanox itraconazole Supeudol oxycodone
Sprycel dasatinib Suppress dextromethorphan
SSKI potassium iodide Supradol naproxen
Stable hydralazine Supran cefixime
Stalevo entacapone, levodopa Suprax cefixime
Stamaril yellow fever vaccine Suprenza phentermine
Stambutol ethambutol Supressin doxazosin
Stangyl trimipramine Suretin tazarotene
Stannous fluoride [SF] fluorides Surmontil trimipramine
Stapenor oxacillin Sustiva efavirenz
Staril fosinopril Sutent sunitinib
suxamethonium succinylcholine Tasigna nilotinib

Sweet’N Low saccharin Taucor lovastatin
Sylatron PEG-interferon Tavanic levofloxacin
Symbicort budesonide, formoterol Tavor lorazepam
Symbol misoprostol Taxagon trazodone
Symbyax fluoxetine, olanzapine Taxol paclitaxel
Symjepi epinephrine Taxotere docetaxel
Symproic naldemedine Taxus tamoxifen
Syn-Minocycline minocycline Tazicef ceftazidime
Syn-Nadolol nadolol Tazorac tazarotene
Synagis palivizumab Tecentriq atezolizumab
Syndros dronabinol Tecfidera dimethyl fumarate
Synflex naproxen Technivie ombitasvir/paritaprevir/ritonavir
Synjardy empagliflozin, metformin Tecoplanin teicoplanin
Synribo omacetaxine Tecprazin praziquantel
Synthroid levothyroxine Teczem diltiazem, enalapril
Syntocinon oxytocin Tedolan etodolac
Syraprim trimethoprim Tefamin aminophylline
Syscor nisoldipine Teflaro ceftaroline fosamil
Sytobex cyanocobalamin Teflin tetracycline
Tega-Cert dimenhydrinate
T Tega-Vert
Tegretol XR
dimenhydrinate
carbamazepine
T-20 enfuvirtide
T-DM1 ado-trastuzumab emtansine Tegretol carbamazepine
T-VEC talimogene laherparepvec Teichomycin-A2 teicoplanin
T3 sodium liothyronine Tekamlo amlodipine
T3 liothyronine Tekturna HCT hydrochlorothiazide
T4 levothyroxine Telachlor chlorpheniramine
Tabalom ibuprofen Teldrin chlorpheniramine
Tabco flecainide Teline tetracycline
Tabrin ofloxacin Temazepam temazepam
Tacex ceftriaxone Tementil prochlorperazine
Tachydaron amiodarone Temesta lorazepam
Tadol tramadol Temgesic buprenorphine
Tafil alprazolam Temodar temozolomide
Tafinlar dabrafenib Tenif atenolol, nifedipine
Taflutan tafluprost Teniken praziquantel
Tagal ceftazidime Tenolin atenolol
Tagamet cimetidine Tenoret 50 atenolol
Tagrisso osimertinib Tenoretic atenolol
Taks diclofenac Tenormin atenolol
Taloken ceftazidime Tenormine atenolol
Taltz ixekizumab Tensin spironolactone
Talwin Compound aspirin Tensipine MR nifedipine
Talwin-NX naloxone Tensopril lisinopril
Tamaxin tamoxifen Teralithe lithium
Tambocor flecainide Teril carbamazepine
Tamiflu oseltamivir, pandemic influenza vaccine (H1N1) Terlipressin terlipressin
Tamofen tamoxifen Ternalax tizanidine
Tamoxan tamoxifen Ternelin tizanidine
Tanzeum albiglutide Tertroxin liothyronine
Tapazole methimazole Tesavel sitagliptin
Tapros leuprolide Testandro testosterone
Taravid ofloxacin Testim testosterone
Tarceva erlotinib Testoderm testosterone
Targiniq naloxone, oxycodone Teston methyltestosterone
Targocid teicoplanin Testopel testosterone
Targretin bexarotene Testotonic ‘B’ methyltestosterone
Tarka trandolapril, verapamil Testovis methyltestosterone
Taro-Ampicillin Trihydrate ampicillin Testred methyltestosterone
Taro-Atenol atenolol Tetradin disulfiram
tetrahydrocannabinol dronabinol Tramal tramadol

Tetramig tetracycline Tramed tramadol
Teveten HCT hydrochlorothiazide Tramol tramadol
Teveten eprosartan Trandate labetalol
Texate methotrexate Transderm-Nitro nitroglycerin
Teysuno tegafur/gimeracil/oteracil Transene clorazepate
Thacapzol methimazole Transtec buprenorphine
Thalomid thalidomide Tranxal clorazepate
THC dronabinol Tranxen clorazepate
Theo-Dur aminophylline Tranxene clorazepate
theophylline ethylenediamine aminophylline Tranxilen clorazepate
Thevier levothyroxine Tranxilium clorazepate
Thiamazol methimazole Trasamlon tranexamic acid
thiamazole methimazole Travatan Z travoprost
Thinex lindane Travatan travoprost
Thioprine azathioprine Travel Tabs dimenhydrinate
Thorazine chlorpromazine Trazalon trazodone
Thyroid-Block potassium iodide Tremfya guselkumab
Thyronine liothyronine Trendar ibuprofen
Thyrozol methimazole Trental pentoxifylline
tiabendazole thiabendazole Tresiba insulin degludec
Tiamate diltiazem Trexan naltrexone
Tiazac diltiazem Tri-Levlen oral contraceptives
Tibinide isoniazid Tri-Norinyl oral contraceptives
TICE BCG BCG vaccine Triadapin doxepin
Tidocol mesalamine Triaken ceftriaxone
Tiempe trimethoprim Triaminic DM dextromethorphan
Tifomycine chloramphenicol Triaminic chlorpheniramine
Tilazem diltiazem Trian triamterene
Tildiem diltiazem Triasox thiabendazole
Timonil carbamazepine Triavil perphenazine
Titus lorazepam Tricodein codeine
Tivicay dolutegravir Tricor fenofibrate
TMP-SMX co-trimoxazole Tridil nitroglycerin
TMP-SMZ co-trimoxazole Tridol tramadol
TOBI tobramycin Triflucan fluconazole
Tobra tobramycin Trijodthyronin BC N liothyronine
TobraDex tobramycin Trikacide metronidazole
Tobrex tobramycin Trilafon perphenazine
Tofranil imipramine Trileptal oxcarbazepine
Tolak fluorouracil Trilifan Retard perphenazine
Toloxim mebendazole Trimopan trimethoprim
Topadol ketorolac Trimox amoxicillin
Topamax topiramate Trimzol co-trimoxazole
Topicort desoximetasone Trinalin pseudoephedrine
Topicycline tetracycline Trintellix (formerly Brintellix) vortioxetine
Toprol XL metoprolol Triomin perphenazine
Toradol ketorolac Triostat liothyronine
Torem torsemide Triphasil oral contraceptives
Toremonil hydroxychloroquine Triprim trimethoprim
Torental pentoxifylline Triptone dimenhydrinate
Torisel temsirolimus Trisoralen psoralens
Torolac ketorolac Trisulfa co-trimoxazole
Torvin ketorolac Tritace ramipril
Totacillin ampicillin Triumeq abacavir, dolutegravir, lamivudine
Totapen ampicillin Trivora oral contraceptives
Toviaz fesoterodine Triz cetirizine
tPA alteplase Trizivir abacavir, lamivudine, zidovudine
Tracleer bosentan Trobalt ezogabine
Tradjenta linagliptin Trocal dextromethorphan
Tradol tramadol Trokendi XR topiramate
Tronoxal ifosfamide Urdox ursodiol

Tropax oxybutynin Urem ibuprofen
Tropium chlordiazepoxide Urex furosemide
Tropyn Z atropine sulfate Urief silodosin
Troxyca naltrexone, oxycodone Urised atropine sulfate, hyoscyamine
Trulance plecanatide Uritol furosemide
Trulicity dulaglutide Uro-cephoral cefixime
Trumenba meningococcal group B vaccine Urobak sulfamethoxazole
Truphylline aminophylline Urocid probenecid
Trusopt dorzolamide Urofuran nitrofurantoin
Truvada emtricitabine, tenofovir disoproxil Uromax oxybutynin
Tryptanol amitriptyline Uroxatral alfuzosin
Tryptizol amitriptyline Urozide hydrochlorothiazide
TS-1 tegafur/gimeracil/oteracil Urso 250 ursodiol
Tussar-2 codeine Urso Forte ursodiol
Tussgen hydrocodone Urso Heumann ursodiol
Tussi-12D phenylephrine Urso Vinas ursodiol
Tussi-Organidin codeine Ursochol ursodiol
Tussionex hydrocodone ursodeoxycholic acid ursodiol
Tussogest hydrocodone Ursofal ursodiol
Twinrix hepatitis B vaccine Ursofalk ursodiol
Tykerb lapatinib Ursoflor ursodiol
Tylenol acetaminophen Ursogal ursodiol
Tylox oxycodone Ursolac ursodiol
Tymlos abaloparatide Ursolism ursodiol
Typherix typhoid vaccine Ursolvan ursodiol
Typhim Vi typhoid vaccine Urson ursodiol
Tysabri natalizumab Ursoproge ursodiol
Tyzeka telbivudine Ursosan ursodiol
Ursotan ursodiol
U USCA
Utibron Neohaler
ursodiol
glycopyrrolate, indacaterol
UDC Hexal ursodiol
UDC ursodiol Utinor norfloxacin
UDCA ursodiol Utradol etodolac
Udrik trandolapril
Uducil cytarabine V
Ulcar sucralfate V-cillin K penicillin V
Ulcedine cimetidine Vabomere meropenem & vaborbactam
Ulcogant sucralfate Vacanyl terbutaline
Ulcol sulfasalazine Vagifem estradiol
Ulcyte sucralfate Valadol acetaminophen
Uloric febuxostat Valcyte valganciclovir
Ulsen omeprazole Valdrene diphenhydramine
Ultra-MOP methoxsalen Valium diazepam
Ultracet tramadol Valni XL nifedipine
Ultram tramadol Valodex tamoxifen
Umbradol salsalate valproate sodium valproic acid
Umine phentermine Valtrex valacyclovir
Unasyn ampicillin/sulbactam Valturna valsartan
Unat torsemide Vamate hydroxyzine
Uniflox ciprofloxacin Vanatrip amitriptyline
Unimazole methimazole Vanceril beclomethasone
Unimetone nabumetone Vancocin vancomycin
Uniparin heparin Vancotil loperamide
Uniretic hydrochlorothiazide Vandazole metronidazole
Unithroid levothyroxine Vaniqa eflornithine
Unitrim trimethoprim Vanmicina vancomycin
Unituxin dinutuximab Vanquish aspirin
Unizuric allopurinol Vaprisol conivaptan
Uptravi selexipag Vaqta hepatitis A vaccine
Urbal sucralfate Varilrix varicella vaccine
Variquel terlipressin Viibryd vilazodone

Varithena polidocanol Vimizim elosulfase alfa
Varivax varicella vaccine Vimpat lacosamide
Varsan lindane Vincasar vincristine
Varubi rolapitant Viracept nelfinavir
Vascal isradipine Viramid ribavirin
Vaseretic enalapril, hydrochlorothiazide Viramune nevirapine
Vasopril fosinopril Virazid ribavirin
Vasostrict vasopressin Virazole ribavirin
Vasotec enalapril Viread tenofovir disoproxil
Vaxchora cholera vaccine Virilon methyltestosterone
Vaxigrip influenza vaccine Virlix cetirizine
Veclam clarithromycin Viromone methyltestosterone
Vectibix panitumumab Vistabel botulinum toxin (A & B)
Velban vinblastine Vistacarpin pilocarpine
Velbe vinblastine Vistaril hydroxyzine
Velcade bortezomib Vistide cidofovir
Veletri epoprostenol Visudyne verteporfin
Velodan loratadine Vita Plus E vitamin E
Velsar vinblastine Vita-E vitamin E
Velsay naproxen Vitak phytonadione
Veltassa patiromer Vitamin B12 cyanocobalamin
Vemlidy tenofovir alafenamide vitamin B3 niacin, niacinamide
Venclexta venetoclax vitamin B9 folic acid
Venoglobulin immune globulin IV vitamin K1 phytonadione
Ventolin albuterol Vitamin K phytonadione
Ventoline albuterol Vitatropine atropine sulfate
VePesid etoposide Vitec vitamin E
Vepeside etoposide Vitrase hyaluronic acid
Veraken verapamil Vivaglobin immune globulin sc
Verelan verapamil Vivatec lisinopril
Vermicol mebendazole Vivelle-Dot estradiol
Vermox mebendazole Vivelle estradiol
Versed midazolam Vividyl nortriptyline
Vertab dimenhydrinate Vivitrex naltrexone
Vertigon prochlorperazine Vivitrol naltrexone
Verzenio abemaciclib Vivol diazepam
Vesanoid tretinoin Vivotif typhoid vaccine
Vesicare solifenacin Vogan vitamin A
Vestra reboxetine Volibris ambrisentan
Vfend voriconazole Volmax albuterol
Viadur leuprolide Voltaren diclofenac
Viaflex heparin Voltarene diclofenac
Viagra sildenafil Voltarol diclofenac
Viberzi eluxadoline Vomacur dimenhydrinate
Vibra-Tabs doxycycline Vomex A dimenhydrinate
Vibramycin-D doxycycline Vomisen dimenhydrinate
Vicapan N cyanocobalamin Vonum indomethacin
Vicard terazosin Vosevi sofosbuvir/velpatasvir/voxilaprevir
Vicks Formula 44 dextromethorphan Vozet levocetirizine
Vicks Vatronol ephedrine VP-TEC etoposide
Vicodin acetaminophen, hydrocodone Vraylar cariprazine
Vicoprofen hydrocodone, ibuprofen Vytorin ezetimibe, simvastatin
Victoza liraglutide Vyvanse lisdexamfetamine
Victrelis boceprevir
Vidaza azacitidine W
Videx didanosine Waran warfarin
Vidopen ampicillin Warfilone warfarin
Viekira Pak ombitasvir/paritaprevir/ritonavir Waytrax ceftazidime
Viekira XR dasabuvir/ombitasvir/paritaprevir/ritonavir Wehamine dimenhydrinate
Viekirax ombitasvir/paritaprevir/ritonavir Welchol colesevelam
Wellbutrin bupropion Zantic ranitidine

Welldorm chloral hydrate Zantryl phentermine
Wigrettes ergotamine Zapex oxazepam
Winobanin danazol Zaponex clozapine
Winstrol stanozolol Zariviz cefotaxime
Wintrocin erythromycin Zarondan ethosuximide
Wyamicin S erythromycin Zarontin ethosuximide
Zavedos idarubicin
X Zebeta
Zebinix
bisoprolol
eslicarbazepine
X MDMA
Xadago safinamide Zecuity sumatriptan
Xalatan latanoprost Zedolac etodolac
Xalkori crizotinib Zefone ceftriaxone
Xanax alprazolam Zeftera ceftobiprole
Xanef enalapril Zejula niraparib
Xarelto rivaroxaban Zelapar selegiline
Xatral alfuzosin Zelboraf vemurafenib
Xelevia sitagliptin Zenapax daclizumab
Xeljanz tofacitinib Zentropil phenytoin
Xeloda capecitabine Zeos loratadine
Xenical orlistat Zepatier elbasvir & grazoprevir
Xeomin botulinum toxin (A & B) Zerbaxa ceftolozane & tazobactam
Xermelo telotristat ethyl Zerit stavudine
Xgeva denosumab Zestoretic hydrochlorothiazide, lisinopril
Xifaxan rifaximin Zestril lisinopril
Xifaxanta rifaximin Zetia ezetimibe
Xigduo XR dapagliflozin, metformin Zeto azithromycin
Xiidra lifitegrast Ziac bisoprolol, hydrochlorothiazide
Xofigo radium-223 dichloride Ziagen abacavir
Xolair omalizumab Zicam zinc
Xomolix droperidol Zimovane eszopiclone
Xozal levocetirizine Zinacef cefuroxime
Xtampza ER oxycodone Zinacet cefuroxime
Xtandi enzalutamide Zinat cefuroxime
Xtoro finafloxacin Zinbryta daclizumab
Xultophy insulin degludec, liraglutide Zinnat cefuroxime
Xusal levocetirizine Zinplava bezlotoxumab
xylocaine lidocaine Zioptan tafluprost
Xylocard lidocaine Zipan tramadol
Xyzal levocetirizine Zipsor diclofenac
Zirtin cetirizine
Y Zithromax
Zitromax
azithromycin
azithromycin
Yamatetan cefotetan ziv-aflibercept aflibercept
Yasmin oral contraceptives Zmax azithromycin
Yaz oral contraceptives Zocor simvastatin
Yectamid amikacin Zocord simvastatin
Yentreve duloxetine Zofran ondansetron
Yervoy ipilimumab Zofron ondansetron
YF-VAX yellow fever vaccine Zohydro ER hydrocodone
Yosprala aspirin, omeprazole Zoldan-A danazol
Yuma hydroxychloroquine Zole miconazole
Yurelax cyclobenzaprine zoledronic acid zoledronate
Zolinza vorinostat
Z Zoloft sertraline
Zaltrap aflibercept ZoMaxx Drug-Eluting Coronary Stent zotarolimus
Zanaflex tizanidine Zometa zoledronate
Zanosar streptozocin Zomig zolmitriptan
Zantab ranitidine Zonegran zonisamide
Zantac-C ranitidine Zontivity vorapaxar
Zantac ranitidine Zorac tazarotene
Zorbenal-G tetracycline Zyclir acyclovir

Zoref cefuroxime Zydelig idelalisib
Zoroxin norfloxacin Zyderm collagen (bovine)
Zortress everolimus Zydone hydrocodone
Zorvolex diclofenac Zyflo zileuton
Zostavax zoster vaccine Zyloprim allopurinol
Zosyn piperacillin/tazobactam Zyloric allopurinol
Zovia oral contraceptives Zymerol cimetidine
Zovirax acyclovir Zynox naloxone
Zumalin lincomycin Zyplast collagen (bovine)
Zunden piroxicam Zyprexa Relprevv olanzapine
Zuplenz ondansetron Zyprexa olanzapine
Zurampic lesinurad Zyrtec cetirizine
Zyban bupropion Zytiga abiraterone
Zyclara imiquimod Zyvox linezolid

Litt&#39;s Drug Eruption &amp; Reaction Manual 24E

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24th

Boca Raton London New York

CRC Press is an imprint of the

© 2018 by Taylor & Francis Group, LLC

No claim to original U.S. Government works

Printed on acid-free paper

International Standard Book Number-13: 978-0-8153-6699-7 (Pack – Paperback and eBook)

Visit the Taylor & Francis Web site at

and the CRC Press Web site at

Litt’s Drug Eruption & Reaction Manual – at a glance

Vigilance at point of care:

Contents of the book, and how to use them

2. Important eruptions / reactions

Local Hematologic Genitourinary

Headache [IV] (10%) [5] Vomiting [2]

Gingivitis (<10%) Other

Chest pain (<5%) Sepsis [2]

Central Nervous System Other Hypokalemia (10%) [3]

Neuromuscular/Skeletal Gastrointestinal perforation [4] Gastrointestinal/Hepatic

busulfan, captopril, carboplatin, carmustine, Depression [3]

Pregnancy category: N/A (Can cause fetal Pneumonia (16%) [3]

Hepatotoxicity [7] Gastrointestinal/Hepatic Nausea [2]

Skin Central Nervous System

Genitourinary ALTEPLASE Skin

ALPROSTADIL Indications: Acute myocardial infarction, acute Mucosal

Pruritus [3] Pregnancy category: C Pregnancy category: N/A

Endocrine/Metabolic Hepatotoxicity [36] Neuromuscular/Skeletal

95% incidence of exanthematous eruptions in Pregnancy category: N/A (Contra-indicated in

Hypoglycemia (7%) Central Nervous System

Pregnancy category: C Other telithromycin, terfenadine, tolbutamide,

Neuromuscular/Skeletal Central Nervous System

Skin Hearing impairment [2]

Nasal polyp [4] romidepsin, rosuvastatin, salmeterol, saquinavir,

Other Cerebral hemorrhage (<5%) Injection-site erythema (35–43%)

Nevi [3] Allergic reactions [5] Churg-Strauss syndrome [2]

BACITRACIN BALSALAZIDE Facial edema (310%)

Respiratory monosodium glutamate, moxifloxacin, ofloxacin,

Pain in extremities [2] Gastrointestinal/Hepatic Cardiovascular

prostacyclin analogues, rituximab, sirolimus, Central Nervous System

Myocardial infarction (<2%) Oliguria (<2%) Diarrhea (2%)

Gastrointestinal/Hepatic Pregnancy category: X

Hyperglycemia (11%) [2]

Gastrointestinal/Hepatic Neuromuscular/Skeletal elbasvir & grazoprevir, enzalutamide,

Pregnancy category: C Diplopia [10] Gastrointestinal/Hepatic

Respiratory Appetite decreased (15–22%) Ocular pruritus (5–20%) [5]

Warning: SUICIDAL IDEATION AND Hair

Pregnancy category: C Warning: ABUSE POTENTIAL, LIFE-

Parkinsonism [2] Exanthems [2]

Hyperuricemia (2%) Polyuria [2]

Hematologic QT prolongation [2]

Pseudolymphoma [2] delavirdine, dexamethasone, diltiazem,

Lymphoproliferative disease [5] Death [6] Paresthesias [2]

Peripheral edema (24%) [3] Other

Gastrointestinal/Hepatic Respiratory Mucosal

Renal failure (<5%) Pregnancy category: B

Facial edema (<2%) DRESS syndrome [4]

Other Skin Skin

Other epidermal necrolysis and Stevens-Johnson

Tendinopathy/Tendon rupture (<2%)

Death [6] Gastroesophageal reflux (<3%) Sedation (prolonged) [2]

Edema (<10%) Gastrointestinal/Hepatic

Corneal opacity [2] doxercalciferol, ergocalciferol,

Hepatotoxicity [7] Hair Febrile neutropenia [36]

Pigmentation [2] Other deflazacort, delavirdine, diazepam, digoxin,

Litt's Drug Eruption & Reaction Manual 24E

Litt's Drug Eruption & Reaction Manual 24E