WE ARE PLEASED TO INVITE YOU TO OUR WORKSHOP

by Dr. Gabriel Serrano Sanmiguel MD, PhD & Dr. Liao Yuan MD, EMBA

Use of Nanopore Microneedling in Dermatology

Briefing about whitening with tranexamic acid

Thursday, December 6th

10:30h - 11.15h / HALL3

Dr. Gabriel Serrano Sanmiguel MD, PhD

Dr Gabriel Serrano is Consultant Dermatologist since 1978 and the owner of the Clinic
Dr Gabriel Serrano in Valencia.
After finishing his degree at University of Valencia he worked at the University General
Hospital as Professor of Dermatology and Clinical Chief of the Department of
Dermatology for more than 25 years.
He started to create master formulas that he would later use in his skincare products
and opened his own clinic in 1978, where he prescribed these products to his patients.
After this success, he founded Sesderma Laboratories in 1989.
Sesderma was the first laboratory in Spain to launch a complete line of treatments with
glycolic acid, and is now the only one which develops a wide variety of products using
nanotechnology.
Dr. Serrano created Nanopore device in 2014, revolutioning microneedling treatments.

Dr. Liao Yuan MD, EMBA

Dr. Liao is a dermatologist who have the high diploma of British Cosmetic Scientists
association, is the specialist of the skin medical beauty.
It has more than 20 years since she dedicated in Dermatology. Dr. Liao worked in Chang
Gung Memorial Hospital (CGMH) as the attendants of the Department of Dermatology
in 1999-2002.
Since 2002, Dr. Liao funded YUAN LI Aesthetic Medical Group in Taiwan. She has
published 12 books for the laymen regarding medical aesthetic tx, correct skin care,
cosmetic skin problems.
She is the founder of the term “Micro Cosmetic Surgery” in Asia.
She is now the Board Director of Strait Exchange Academy for Dermatology and
Esthetic Medicine, Taiwan (SEA-DEM) and a member of TDA, Chinese medical laser
association, CASR in China.
 What is NANOPORE stylus?
NANOPORE stylus is an electrical microneedling medical device.
Induces and regenerates the skin’s collagen via intercelular communication therapy. Medical device for intercellular communication therapy

INDICATIONS ACTION MECHANISM

Wrinkles Hyperpigmentations
Photoaging Flaccidity 1 Physical and mechanical stimulus
Dilated pores Cellulite The inflammatory cascade (release of interleukins, cytokines
Stretch marks Scars and growth factors) activates the production of collagen and
elastin.
Alopecia Eye bags and dark circles
Improves communication between dermis and epidermis
Hypopigmentation Acne (keratinocyte and melanocyte) increasing signals through the
dermal-epidermal connectors.
Improves intercellular communication
TRIPLE-ACTION
MICRONEEDLES

1 Increases transdermal penetration WITH WITHOUT

2 Combination with serum with growth factors
Microperforation of the stratum
Lubricates needles Reduces pain and epidermal trauma.
corneum increases the permeability
and penetration of active ingredients. Individual treatment Growth factors cocktail.
Liposomal solution combined with
Micro-holes close in 10 minutes. microneedles. Transport of active ingredients to dermal and epidermal levels.
PENETRATION IS 200 TIMES GREATER.
Scientific Evidence: It has been demonstrated that only
0.3% of a topical cosmetic application (Fluorescein),
Penetrates through the skin. Using microneedles,
penetration of Fluorescein liposomes is 200 times greater.

2 Repairs the dermal matrix CONTROL BIOPSY Biopsy 6 weeks

after treatment

Increases the production of collagen 0.0

0.1 Serum
by means of natural skin repair
mechanisms.
0.5

Connection
Scientific Evidence: Collagen stained purple. INCREASE OF
1 Receptor
1000% increase in presence of collagen and elastic COLLAGEN
fibers to a depth of about 0.5 and 0.6 mm.
Transduction Tyrosine-kinase

3 signal to nucleus activity

Improves intercellular communication
Nucleus
Produces signs that improve intercellular communication (crosstalk) 2
CELL
responsible for preserving the barrier function, pigmentation, elasticity of Gene activation
DIVISION
the collagen fibres and elastin in the skin.

PENETRATION DEPTH AND SPEED

RECOMMENDED
PENETRATION LEVELS
0.25 mm
0.5 mm

1.0 mm

1.5 mm

Forehead: 0.5 mm
Epidermis 150 pulsations / second
0.07 - 0.17 mm
Eyelids: 0.25 mm
EPIDERMIS - DEPTH Wrinkles at outer corner of eye: 0.5 mm
120 pulsations / second
150 pulsations / second
Cheeks: 0.5 mm
Basal membrane 150 pulsations / second
DERMIS
In case of very noticeable lesions
Dermis 1.7 - 2mm Upper lip contour: 0.25/0.5 mm (for example, hypertrophic scars)
150 pulsations / second it is possible to use a length
SKIN BIOPSY 100 x HYPODERMIS ≥ 1.0 mm FOCALLY.
(Hematoxylin and Eosin Staining) + DEPTH

PROVEN RESULTS

BEEFORE AFTER BEEFORE AFTER

ALOPECIA ACNE SCARS

ANTI-AGEING MELASMA