AGRA PUBLIC PHARMACY COLLEGE, ARTONI, AGRA

LESSON PLAN
Session: Even Semester 2019-20
Course: M. Pharm. I Year Semester: II
Subject: Computer Aided Drug Delivery - Theory Subject Code: MPH 203T

Unit No./ Topics to be covered Number of Content from the Proposed Date of Remark
Name lectures Syllabus (S) OR Date Lecture
Beyond the Delivery
Syllabus (BS)
Unit I A general overview & History of computers in 1 S 23-01-20
pharmaceutical research and development.
Statistical modelling in pharmaceutical research 1 S 24-01-20
and development.
Descriptive versus mechanistic modelling. 1 S 25-01-20
Statistical parameters. 1 S 27-01-20
Statistical estimation of data. 1 S 28-01-20
Confidence regions of data. 1 S 29-01-20
Nonlinearity at the optimum 1 S 30-01-20
Sensitivity analysis 1 S 31-01-20
Optimal design 1 S 01-02-20
Population modelling 1 S 03-02-20
ICH Q8 guidelines for quality by design. 1 S 04-02-20
Regulatory and industry views on ICH QbD, 1 S 05-02-20
Unit II Introduction to computational Modelling of Drug 1 S + BS 06-02-20
Disposition.
Modelling techniques. 1 S 10-02-20
Drug absorption. 1 S 11-02-20
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Drug solubility. 1 S 12-02-20

Drug distribution 1 S 13-02-20
Drug excretion 1 S 17-02-20
Intestinal permeation 1 S 18-02-20
Active transports as P-gp & BCRP. 1 S 19-02-20
BBB-choline transporter. 1 S 20-02-20
Nucleoside transporters. 1 S 24-02-20
hPEPT1, OATP transporters. 1 S 25-02-20
ASBT, OCT transporters. 1 S 26-02-20
Unit III Introduction to computer-Aided Formulation 1 S + BS 27-02-20
Development.
Concept of optimization. 1 S 02-03-20
Optimization parameters. 1 S 03-03-20
Factorial designs. 1 S 04-03-20
Optimization technology & screening design. 1 S 11-03-20
Use of computers in pharmaceutical formulation. 1 S 12-03-20
Development of pharmaceutical emulsions. 1 S 16-03-20
Microemulsion and other drug carriers. 1 S 17-03-20
Legal protection of innovative works. 1 S 18-03-20
Uses of computers in R&D. 1 S 19-03-20
The ethics of computing in pharmaceutical 1 S 23-03-20
research.
Computers in market analysis. 1 S 24-03-20
Unit IV Computer-Aided Biopharmaceutical 1 S 25-03-20
Characterization: Gastrointestinal absorption
simulation.
Introduction, theoretical background, model 1 S 26-03-20
construction,
Parameter sensitivity analysis. 1 S 01-04-20
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Virtual trial for fed vs. fasted state. 1 S 07-04-20

In vitro dissolution and in-vitro in-vivo 1 S 08-04-20
Correlation. 09-04-20
Bio-waiver considerations. 1 S 13-04-20
Computer Simulations in Pharmacokinetics and 1 S 14-04-20
Pharmacodynamics
Introduction to computer simulation: Whole 1 S 15-04-20
organism.
Isolated tissues & organs. 1 S 20-04-20
Cell, proteins and genes. 1 S 21-04-20
Computers in Clinical Development. 1 S 23-04-20
Clinical data collection, management and 1 S 30-04-20
regulation of computer systems.
Unit V Artificial Intelligence (AI) 2 S + BS 4-05-20
5-05-20
Robotics 2 S + BS 6-05-20
11-05-20
Computational Fluid Dynamics 2 S + BS 12-05-20
13-05-20
Pharmaceutical automation 1 S 14-05-20
Pharmaceutical applications 1 S 18-05-20
Advantages and disadvantages 1 S 19-05-20
Current challenges 1 S 20-05-20
Future directions. 2 S + BS 21-05-20
26-05-20
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LIST OF EXPERIMENT
Session: Even Semester 2019-20
Course: M. Pharm. I Year Semester: II
Subject: Pharmaceutics Practical-II Subject Code: MPH 205P

S. Object Syllabus (S)/ Proposed Date of Remark

No. Beyond the Date of Conduct
Syllabus (BS) conduct
1. To study the effect of temperature change, non solvent addition, incompatible S 31-01-2020
polymer addition in microcapsule preparation. 01-02-2020
2. Preparation and evaluation of alginate beads. S 07-02-2020
08-02-2020
3. Formulation and evaluation of gelatin microspheres. S 14-02-2020
15-02-2020
4. Formulation and evaluation of albumin microspheres. S 22-02-2020
5. Formulation and evaluation of liposomes. S 28-02-2020
29-02-2020
6. Formulation and evaluation of niosomes. S 13-03-2020
14-03-2020
7. Formulation and evaluation of spherules. S 20-03-2020
21-03-2020
8. Improvement of dissolution characteristics of slightly soluble drug by Solid S 27-03-2020
dispersion technique. 28-03-2020
9. Comparison of dissolution of two marketed products of different brands. S 03-04-2020
04-04-2020
10. Protein binding studies of a highly protein bound drug & poorly protein bound drug. S 11-04-2020
11. Development and evaluation of creams. S 17-04-2020
18-04-2020
12. Development and evaluation of shampoo and toothpaste. S 24-04-2020
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25-04-2020
13. To incorporate herbal and chemical actives to develop products. S 01-05-2020
02-05-2020
14. Development and evaluation of herbal product to address dry skin, acne or wrinkles. S+BS 08-05-2020
09-05-2020
15. Development and evaluation of herbal product to address dandruff. S+BS 15-05-2020
16-05-2020