CHRONIC KIDNEY DISEASE

IRREVERSIBLE LOSS OF NEPHRONS

LIFESTYLE GENETIC/ ACQUIRED

ACUTE RENAL FAILURE DIABETES HYPERTENSION

DM 1 DM 2 INCREASED BLOOD
PRE-RENAL CAUSES
PRESSURE (BP
HYPERGLYCEMIA >120/80mmHg)
RENAL ARTERY SCLEROSIS

INCREASE GLUCOSE THICKENING OF BLOOD

HEART FAILURE
FILTRATION VESSELS

HEMORRHAGE
STRESSING/STRAINING NARROWING OF LUMEN
OF KIDNEY
INTRA-RENAL CAUSES
LESS BLOOD FLOW TO
INCREASED BLOOD THE KIDNEY
GLUMERULONEPHRITIS PRESSURE IN BLOOD
VESSELS OF KIDNEY
TUBULAR NECROSIS DECREASED
INFILTRATION
INTERSTITIALNEPHRITIS DIABETIC NEPHROPATHY

MESENGIAL EXPANSION/ SCLEROSIS ACTIVATION OF

PROLIFERATION RENIN-
POST-RENAL CAUSES ANGIOTENSIN
PUDOCYTOPHATHY SYSTEM
RENAL STONES
HYPERTROPHY
INCREASED HEART
RENAL HYPERPLASIA RATE
ATROPHY

TUMOR GLOMERULUSCLEROSIS

(THICKENING/
HARDENING OF BLOOD
OBSTRUCTION IN URINARY FLUID RETENTION
VESSELS IN
TRACT GLUMERULUS)
HYPERKALEMIA

ACUTE KIDNEY INJURY DAMAGE TO BLOOD VESSELS

IRREVERSIBLE
KIDNEY MALFUNCTION
DAMAGE TO THE KIDNEY