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Objective 76.8 Identify the regulatory mechanisms, influencing factors, target actions, and
physiological functions of antidiuretic hormone (ADH) secretion.
The main purpose of ADH is to maintain blood pressure homeostasis. By secreting (or not
secreting) ADH, the body can control blood pressure. First, we review some definitions...
The change of concentration of ADH from small amount to large amount in the body
fluid is rapid (only a few minutes) in order to balance blood osmolarity.
When the extracellular body fluid becomes highly concentrated, water in the
osmoreceptor diffuses out of the cell membrane by osmosis decrease
the size of osmoreceptor initiates the nerve impulses in the
hypothalamus impulses are transmitted to the posterior pituitary
cause secretion of ADH, water retention in kidney.
Please
release
ADH!
When the extracellular fluid becomes too dilute, water diffuses into the
osmoreceptor increase the cell size of the osmoreceptor decrease
the signal for ADH secretion, water excretion at kidney.
Stop
releasing
ADH!
The reflex impulses from baroreceptors are transmitted to brain to inhibit ADH
secretion.
Decreases excretion of water by kidney. In other words, ADH conserves (or retains)
water by promoting it to go in the direction of urine back into the blood.
The luminal membranes of the tubular cells are almost impermeable to water in
the absence of ADH. The luminal membrane thus separates 'blood' from urine.
When ADH is released into blood and is transported to kidney, it binds with the
receptors on luminal membranes cause formation of cAMP cause
phosphorylation of chemicals in the special vesicles vesicles insert into
apical cell membrane increase the permeability of collecting tubules and
ducts to water water is reabsorbed from the collecting tubules and duct
by osmosis water is conserved in the body producing very
concentrated urine.
Vasopressin Effect:
Remember, ADH is also called vasopressin, because it has another type of effect that
happens at the same time but in a different location. High concentration of ADH causes
constriction of arterioles throughout the body to increase the arterial pressure. ADH
thus has effects on arterial resistance. This is called a 'pressor' response.
When the blood volume or blood pressure decreases, secretion of ADH then
constriction (tightening) of blood vessels.
By making blood vessels smaller, it helps to increase the blood pressure. This works together
with the renal effects, which are to bring in more water which maintains blood pressure.
When blood pressure goes above the normal value, then the process works in reverse:
If blood pressure is high ADH is no longer secreted, water is excreted by the kidney into
urine, and the arterioles relax, which lowers blood pressure. Homeostasis will eventually
bring blood pressure to the optimal point, as determined by continuous monitoring by
the baroreceptors in the heart and osmoreceptors of the hypothalamus.