Documente Academic
Documente Profesional
Documente Cultură
Infections
By
John Chen
Pharm.D., Ph.D., O.M.D., L.Ac.
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Chinese Herbology and
Pharmacology 张仲景 Zhāng Zhòng-Jĭng, 150-219 CE
• wen yi (warm epidemic) are “not caused by wind, • 温热论 Wen Re Lun
cold, summer-heat, nor dampness, but rather by (Discussion of Warm
戾气 li qi (perverse qi).” and Hot Disorders)
• He further elaborated that li qi (perverse qi)
existed
i t d iin th
the universe,
i b
butt h
have ““no sound
d nor
smell, and no shape nor shadow.”
• Lastly, he observed that li qi (perverse qi) may be
transmitted from one person to another via
“heaven [air borne]” or “earth [direct contact],”
and affect weak, deficient individuals (i.e., those
with low immunity).
• •
Gui Zhi Tang (Cinnamon Twig Decoction) Gui Zhi Tang (Cinnamon Twig Decoction)
• Ge Gen (Radix Puerariae Lobatae) • Taiyang syndrome with wind-cold invasion: severe
• Ma Huang (Herba Ephedrae) muscle stiffness of the neck and back, aversion to
cold, with or without fever, aversion to wind, absence
• Gui Zhi (Ramulus Cinnamomi) of perspiration, and diarrhea.
• Bai Shao (Radix Paeoniae Alba) • Fever, common cold, influenza, infectious parotitis,
• Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae upper respiratory tract infection, allergic rhinitis,
Praeparata cum Melle) chronic rhinitis, neck and shoulder stiffness and pain,
• Sheng Jiang (Rhizoma Zingiberis Recens) periarthritis of shoulder, tendonitis or bursitis of the
shoulders, soft tissues injuries, facial paralysis, Bell’s
• Da Zao (Fructus Jujubae) palsy, meningitis, encephalitis, tension headache,
scleroderma, urticaria, and diarrhea.
Sang Ju Yin (Mulberry Leaf and Sang Ju Yin (Mulberry Leaf and
Chrysanthemum Decoction) Chrysanthemum Decoction)
• Sang Ye (Folium Mori) • Early stage of wind-warmth syndrome: cough,
• Ju Hua (Flos Chrysanthemi) mild fever, and slight thirst.
• Bo He (Herba Menthae) • Common cold, influenza, acute bronchitis, acute
• Lian Qiao (Fructus Forsythiae) tonsillitis, coughing, and other upper respiratory
infections.
• Jie Geng (Radix Platycodonis)
• Ku Xing Ren (Semen Armeniacae Amarum)
• Lu Gen (Rhizoma Phragmitis)
• Gan Cao (Radix et Rhizoma Glycyrrhizae)
• •
•
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.
Jin Yin Hua (Flos Lonicerae Japonicae) Jin Yin Hua (Flos Lonicerae Japonicae)
Jin Yin Hua (Flos Lonicerae Japonicae) Lian Qiao (Fructus Forsythiae)
•
Chen J and Chen T. Chinese Medical Herbology and Pharmacology. Art of Medicine Press. 2004.
Ban Lan Gen (Radix Isatidis) Ban Lan Gen (Radix Isatidis)
• •
• Antiviral: Ban Lan Gen exerts antiviral effect • Clears heat and
against influenza A virus, seasonal influenza eliminates toxins
virus, human or avian influenza virus, novel • Cools blood and
swine-originating influenza virus, Japanese eliminates maculae
encephalitis virus, adenovirus, herpes simplex
virus, hepatitis B virus, human cytomegalovirus,
swine pseudorabies virus, coxsackie virus B3.
• Hsuan SL, et al. The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies
virus. J Ethnopharmacol. 2009 May 4;123(1):61-7. Epub 2009 Mar 4.
• Chen C, et al. Zhongyao Yaolixue, 2nd Edition. Shanghai Science and Technology Publishing, 2015; 88-90.
• Yang Z, et al. Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A
and B viruses in vitro. Int J Mol Med. 2013 Apr;31(4):867-73.
• Wang XL, et al. Chemical consitituents from root of Isatis indigotica. Zhongguo Zhong Yao Za Zhi. 2013
• Apr;38(8):1172-82. •
• •
• •
•
2003;31(3):355-62.
Lau KM, et al. Immunomodulatory and anti-SARS activities of Houttuynia cordata.J Ethnopharmacol. 2008 Jun
and abscesses.
19;118(1):79-85. doi: 10.1016/j.jep.2008.03.018. Epub 2008 Mar 30.
• Chou SC, et al. The constituents and their bioactivities of Houttuynia cordata. Chem Pharm Bull (Tokyo). 2009
Nov;57(11):1227-30.
•• Ren X, et al. The effect of Houttuynia cordata injection on pseudorabies herpesvirus (PrV) infection in vitro. Pharm •
Biol. 2011 Feb;49(2):161-6.
• Hayashi K, et al. Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1,
influenza virus, and HIV. Planta Med. 1995 Jun;61(3):237-41.
• •
• Xiaofeng Y, et al. Geniposide, an iridoid glucoside derived from Gardenia jasminoides, protects
Carlos del Rio, MD; Preeti N. Malani, MD. JAMA. Published online February 5, 2020. doi:10.1001/jama.2020.1490
against lipopolysaccharide-induced acute lung injury in mice. Planta Med. 2012 Apr;78(6):557-64.
• As of February 4, 2020: • The innate immune system is the first line of defense
– more than 20 000 cases of 2019-nCoV reported against pathogens. Cells in that system respond
– more than 400 deaths immediately to foreign invaders. (The adaptive
– 98.9% of them in China
immune system, by contrast, learns to recognize
specific
ifi pathogens,
th b
butt ttakes
k llonger tto join
j i th
the
– median age of patients is between 49 and 56 years
battle.)
– very rare in children (2 cases only)
• The innate immune response is stronger in children
exposed to 2019 nCoV, as they fight off infection
more readily than adults, suffering only mild
symptoms.
Carlos del Rio, MD; Preeti N. Malani, MD. JAMA. Published online February 5, 2020. doi:10.1001/jama.2020.1490 Carlos del Rio, MD; Preeti N. Malani, MD. JAMA. Published online February 5, 2020. doi:10.1001/jama.2020.1490
Herbs with Immunostimulant Effect Yu Ping Feng San (Jade Windscreen Powder)
• Ba Ji Tian (Radix Morindae Officinalis), Bai Bian Dou (Semen Lablab Album), Bai Shao (Radix
Paeoniae Alba), Ban Lan Gen (Radix Isatidis), Bie Jia (Carapax Trionycis), Chan Su (Venenum • Huang Qi (Radix Astragali)
Bufonis), Ci Wu Jia (Radix et Rhizoma seu Caulis Acanthopanacis Senticosi) , Da Suan (Bulbus Allii
Sativi), Dang Gui (Radix Angelicae Sinensis), Dang Shen (Radix Codonopsis), Dong Chong Xia Cao
(Cordyceps), Du Zhong (Cortex Eucommiae), E Jiao (Colla Corii Asini), Fang Feng (Radix
• Bai Zhu (Rhizoma Atractylodis Macrocephalae)
Saposhnikoviae), Fu Ling (Poria), Fu Zi (Radix Aconiti Lateralis Praeparata), Gan Cao (Radix et
Rhizoma Glycyrrhizae), Ge Jie (Gecko), Ge Qiao (Concha Meretricis seu Cyclinae), Gou Qi Zi (Fructus • Fang Feng (Radix Saposhnikoviae)
Lycii), Gui Ban (Plastrum Testudinis), Hai Shen (Strichopus Japonicus), He Shou Wu (Radix Polygoni
Multiflori), Huang Jing (Rhizoma Polygonati), Huang Lian (Rhizoma Coptidis), Huang Qi (Radix
Astragali), Jiao Gu Lan (Rhizoma seu Herba Gynostemmatis), Jin Yin Hua (Flos Lonicerae Japonicae),
Ling Zhi (Ganoderma), Long Dan (Radix et Rhizoma Gentianae), Long Yan Rou (Arillus Longan), Lu
Xian Cao (Herba Pyrolae), Mai Dong (Radix Ophiopogonis), Nu Zhen Zi (Fructus Ligustri Lucidi), Pu
Gong Ying (Herba Taraxaci), Qing Mu Xiang (Radix Aristolochiae), Ren Shen (Radix et Rhizoma
Ginseng), San Qi (Radix et Rhizoma Notoginseng), Sang Shen (Fructus Mori), Sha Yuan Zi (Semen
Astragali Complanati), Shan Yao (Rhizoma Dioscoreae), Shan Zha (Fructus Crataegi), She Xiang
(Moschus), Shi Gao (Gypsum Fibrosum), Suan Zao Ren (Semen Ziziphi Spinosae), Suo Yang (Herba
Cynomorii), Tian Ma (Rhizoma Gastrodiae), Tu Si Zi (Semen Cuscutae), Wu Mei (Fructus Mume), Xian
Mao (Rhizoma Curculiginis), Xiang Ru (Herba Moslae), Yin Yang Huo (Folium Epimedii), Yu Xing Cao
(Herba Houttuyniae), Zhu Ling (Polyporus) and Zi He Che (Placenta Hominis).
清肺排毒汤 Qing Fei Pai Du Tang 清肺排毒汤 Qing Fei Pai Du Tang
(Clear the Lung and Eliminate Toxins Decoction) (Clear the Lung and Eliminate Toxins Decoction)
• Ma Huang (Herba Ephedrae), 9g • Jiang Ban Xia (Rhizoma Pinelliae Praeparatum
• Zhi Gan Cao (Radix et Rhizoma Glycyrrhizae cum Zingibere et Alumine), 9g • Drink the warm decoction twice daily 40
Praeparata cum Melle), 6g • Sheng Jiang (Rhizoma Zingiberis Recens), 9g minutes after meals. Folllow with half to
• Ku Xing Ren (Semen Armeniacae Amarum), 9g • Zi Wan (Radix et Rhizoma Asteris), 9g
• Shi Gao (Gypsum Fibrosum), 15-30g (pre-decoct) • Kuan Dong Hua (Flos Farfarae), 9g one bowl of rice porridage.
• Gui Zhi (Ramulus Cinnamomi), 9g • She Gan (Rhizoma Belamcandae), 9g
• Ze Xie (Rhizoma Alismatis), 9g • Xi Xin (Radix et Rhizoma Asari), 6g • Dosage
D off Shi Gao
G (Gypsum
(G Fibrosum)
Fib )
•
•
Zhu Ling (Polyporus), 9g
Bai Zhu (Rhizoma Atractylodis Macrocephalae), 9g
•
•
Shan Yao (Rhizoma Dioscoreae), 12g
Zhi Shi (Fructus Aurantii Immaturus), 6g
should be adjusted based on severity of
• Fu Ling (Poria), 15g • Chen Pi (Pericarpium Citri Reticulatae), 6g fever.
• Chai Hu (Radix Bupleuri), 16g • Guang Huo Xiang (Herba Pogostemonis), 9g
• Huang Qin (Radix Scutellariae), 6g
•
国家中医药管理局; https://mp.weixin.qq.com/s/0U9tAMdfQfrWZz_43Bc0bg 国家中医药管理局; https://mp.weixin.qq.com/s/0U9tAMdfQfrWZz_43Bc0bg
•
心德园 https://mp.weixin.qq.com/s/hY--Q0-lotoWM44Not5DvA
• https://www.who.int/emergencies/diseases/novel- • https://www.nejm.org/doi/full/10.1056/NEJMoa20
coronavirus-2019 01017
• https://www.cdc.gov/coronavirus/2019- • https://jamanetwork.com/journals/jama/pages/cor
ncov/about/index.html onavirus alert
onavirus-alert
• https://www.fda.gov/emergency-preparedness- • https://www.thelancet.com/journals/lancet/article/
and-response/mcm-issues/novel-coronavirus- PIIS0140-6736(20)30305-6/fulltext
2019-ncov
• https://www.nih.gov/health-
information/coronavirus