UNIVERSITY OF SANTO TOMAS

FACULTY OF PHARMACY
PHA 615 LECTURE
PHARMACEUTICAL ORGANIC CHEMISTRY

Alkenes Reaction Worksheet

Instructions. Given are the reactants together with their respective catalysts. Draw the product to be
formed and write the specific reaction of the electrophilic addition.

Note: Start to memorize the co-reactants, catalysts, and the type of reaction for the Shifting Examination.

Reactants with catalyst Product formed Specific

Reaction of
Electrophilic
Addition

 H3PO4

 H3PO4

 H3PO4

 HgCH3COO, H2O
NaBH4

H3PO4 (anti-
Markovnikov)

 BH3/THF
H2O2, NaOH, H2O

+ CH3CH2OH

+ CH3CH2CH2OH

University of Santo Tomas

Faculty of Pharmacy
PHA 615 Lec - Alkene Reactions 1/4 | P a g e
 Reactants with catalyst Product formed Specific
Reaction of
Electrophilic
Addition
CH

H3C CH2 + Br  DCM/CCl4

2

+ Cl2 
DCM/CCl4

+ Cl2  DCM/CCl4

+ Cl2/H2O

+ Br2/H2O

+ Cl2/H2O

Reactants with catalyst Product formed Specific

Reaction of
Electrophilic
Addition

+ H2  Pd/PtO2
NH

+ 2H2  Pd/PtO2

+ 2H2  Pd/PtO2

University of Santo Tomas

Faculty of Pharmacy
PHA 615 Lec - Alkene Reactions 2/4 | P a g e
 Reactants with catalyst Product formed Specific
Reaction of
Electrophilic
Addition

+ mCPBA
NH

+ mCPBA

+ mCPBA

+ mCPBA

Reactants with catalyst Product formed Specific

Reaction of
Electrophilic
Addition

+ KMnO4  H2O
NaOH

+ KMnO4  H2O
NaOH

+ KMnO4  H2O
NaOH
CH2

+ KMnO4  H3O+
CH2

+ KMnO4  H3O+

University of Santo Tomas

Faculty of Pharmacy
PHA 615 Lec - Alkene Reactions 3/4 | P a g e
 H2C

+ KMnO4  H3O+

+ KMnO4  H3O+

+ KMnO4  H3O+

+ KMnO4  H3O+

Reactants with catalyst Product formed Specific

Reaction of
Electrophilic
Addition

 O3, Zn

 O3, Zn

 O3, Zn

 O3, Zn

 O3, Zn
6 BzO• + 3CH2=CH2

University of Santo Tomas

Faculty of Pharmacy
PHA 615 Lec - Alkene Reactions 4/4 | P a g e