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content. It was found that only when the the sexes in the attitudes and emotions related
protein component of the meal was less than to this behaviour. Men who report food cravings
2 per cent did the resulting amino acid profile typically interpret them as being initiated by
favour a rise in serotonin levels in the brain. hunger, whereas women are more likely to link
Benton and Donohoe (1999) highlight that cravings with negative moods, stress and bore-
even in foods considered to be high in carbohy- dom. Negative feelings, such as guilt and
drate, such as bread and potatoes, 15 per cent remorse following indulgence in the craved
and 10 per cent of calories respectively come foods, also appear more frequently in women
from protein. This means that there are very few (Macdiarmid and Hetherington 1995). Often, a
instances when the level of carbohydrate in a craved food is a ‘forbidden’ food, such as choco-
meal is high enough to have a direct impact on late, which probably contributes to women
serotonin levels. labelling themselves as addicts or chocoholics.
Carbohydrate craving itself is a misnomer.
Foods that are commonly craved, particularly by TIME OUT 1
women (Drewnowski et al 1994), are chocolate,
Why is chocolate such a
ice cream, doughnuts, cakes and biscuits. These
commonly craved food and is
foods all taste sweet and so are perceived as
there such a thing as a
being rich in sugar – a carbohydrate. But, in fact, chocoholic?
most of the calories from these foods are actu-
ally provided by fat. In addition, these foods all
contain enough protein to negate any effect of
Is chocolate addictive?
carbohydrate on brain serotonin. For example,
about 8 per cent of calories in ice cream and Gibson and Desmond (1999) have summarised
about 5 per cent in chocolate are from protein. the evidence relating to whether psychoactive
So there must be another reason why these substances in chocolate create a true drug-like
foods are commonly craved. addiction. Cocoa contains a number of poten-
tially psychoactive chemicals:
■ Anandamides, which act at the same site in
The pleasure principle
the brain as cannabis.
Pleasure plays a significant role in determining ■ Tyramine and phenylethylamine, which act in
food choice, as people tend to consume foods a similar manner to amphetamine.
they enjoy eating and avoid those they don’t. ■ Theobromine and caffeine, which are both
However, pleasure is not a simple or universally known to have stimulant properties.
agreed property of a food, but an interplay For these chemicals to create an addiction, they
between the individual’s current physiological would need to be present in doses shown to have
needs, such as hunger level, previous experience a pharmacological effect. However, these sub-
of eating a particular food, and the food’s stances are present at low concentrations in
sensory properties. chocolate. For example, it has been shown that
The pleasure of eating could be enhanced by 2 to 3g of phenylethylamine is needed to have an
opioids such as β-endorphins, which are antidepressant effect, but a 50g bar of chocolate
released in the body as the food is eaten. Drugs contains only a third of a milligram (BNF 1998).
that mimic opioids, such as morphine, have been Some of the chemicals in chocolate are also
shown to increase food intake, whereas drugs present in other foods at similar or higher doses.
such as naloxone, which block opioid receptors, For example, tyramine is present in larger doses
reduce food intake (Drewnowski et al 1994). in cheese, yeast extract and pickled herrings, yet
Perhaps craving for highly desirable foods is these are not regularly described as craved foods
simply down to the pursuit of pleasure. Eating (Gibson and Desmond 1999).
foods we enjoy is likely to improve mood, just as Michener and Rozin carried out a classic study
doing anything we enjoy is likely to cheer us up. in 1994, which clearly demonstrated that choco-
late craving is due to sensory factors rather than
the presence of pharmacologically active sub-
The effects of cravings
stances. Participants were given a series of boxes
A food craving can be described as an urge to that contained milk chocolate, white chocolate,
eat a particular food. Cravings appear to be cocoa powder capsules or white chocolate with
commonplace and at least 60 per cent of people cocoa. When the participants experienced a
report that they experience them (Gibson and chocolate craving, they opened a box and ate the
Desmond 1999). There are differences between contents. If the chemicals in cocoa are responsible
for chocolate craving, the consumption of pure accompanied by feelings of tiredness, low mood
Table 1. Glycaemic index of
cocoa should alleviate the craving. and possibly even dizziness and shaking. These
selected foods
It was found that milk chocolate satisfied the lows are often suffered in the mid-morning or
Food Glycaemic craving, whereas white chocolate was not so mid-afternoon.
index* effective. Adding cocoa to white chocolate did Although many people report these symp-
not make any difference and cocoa powder was toms, they are very rarely associated with low
Glucose 138 not effective at all. White chocolate provides the blood sugar levels except in people with
Cornflakes 119 texture but not the full taste of milk chocolate. diabetes who are taking medication (Williams,
Chips 107 It seems, therefore, that chocolate craving is personal communication). Under normal circum-
White bread 100 down to the pleasure principle – people want its stances, blood sugar levels are kept under
Mashed potatoes 100 unique taste and feel in the mouth. tight control by hormones such as insulin
Wholemeal bread 99 and glucagon. However, symptoms similar to
Shredded wheat 99 those of hypoglycaemia can be induced by stress,
Porridge 87 Premenstrual cravings
particularly hyperventilation or over-breathing.
Cakes 87
There is good evidence that food intake varies Many people who suffer hyperventilation are
Sugar (sucrose) 87
throughout the menstrual cycle in most women. unaware that their breathing pattern has
Chocolate 84
Banana 83 Vlitos and Davies (1996) reviewed the studies changed, but this can be enough to change
White rice 81 examining the amount and types of food con- blood chemistry and cause a variety of distressing
Muesli 80 sumed at different phases of the menstrual symptoms. These symptoms are related to
Boiled potatoes 80 cycle. They found that studies reported an stress and anxiety in many cases, and normally
Popcorn 79 increase in calorie intake premenstrually. These clear up when the cause is recognised and
Brown rice 79 increases ranged between 4 and 35 per cent treated.
Sweetcorn 78 above the amount of calories consumed post- Although it is perceived that sugar(sucrose)-
Orange juice 74 menstruation, with the lowest calorie intake rich foods have the greatest impact on blood
White spaghetti 59 being around the time of ovulation. sugar levels, this is not the case. The glycaemic
Brown spaghetti 53
Other studies have examined basal metabolic index (GI) is used to assess the blood glucose
Apple 52
rate (BMR) throughout the menstrual cycle. It response of a food. GI cannot be predicted
Lentils 38
Fructose 32 has been demonstrated that BMR rises premen- based on whether the carbohydrate is in the
Soya beans 23 strually and drops around the time of ovulation form of starch or sugar (Table 1). In fact, sucrose
Peanuts 21 (Bisdee et al 1989). Women are often aware of (table sugar) has a lower GI than either white or
an increased premenstrual appetite and it wholemeal bread. The form of the food is
*Glycaemic index is the appears that this is partly in response to important, however. Foods where the starch is
impact that a food has on increased energy expenditure at that time. less available for digestion, such as pasta, are
blood glucose levels relative to Apart from an increased appetite, cravings, absorbed more slowly than bread. Similarly, fat
the effect of white bread particularly for sweet foods, are also reported to slows down the absorption of carbohydrate,
be more common premenstrually. Studies exam- which is why chocolate has a lower GI than pure
(Food and Agriculture
ining food intake have found that, although sugar or potatoes.
Organisation/World Health
there is an increase in carbohydrate consump-
Organization 1998)
tion, there is also an increase in fat and protein TIME OUT 3
intake (Vlitos and Davies 1996). In other words,
Using reference material,
carbohydrate intake does not increase dispro-
explain the mechanism
portionately to other nutrients. Barr et al (1995) behind the control of blood
suggest that the cravings represent appetite, sugar levels and how levels are
rather than a specific craving for carbohydrate. controlled when food is eaten.
TIME OUT 2
What explanation and advice
Carbohydrate and alertness
would you give to female
patients asking about A recent major review of the effects of
premenstrual cravings for sweet carbohydrate-rich meals and drinks on mood and
foods? alertness (Reid and Hammersley 1999) examined
the results of all human studies since 1983. Half
of the studies reported some evidence that
Mid-morning blues
carbohydrate had an effect on alertness. Most of
Many people believe that eating sugar-rich these studies found that consuming carbohy-
foods causes a ‘rush’ in blood sugar, which is drate made people more sleepy and relaxed.
followed by a fall in blood sugar (hypoglycaemia), In contrast, the other studies found no specific
evidence that light or moderate drinking could appetite and do not eat properly, and anti-
actually be beneficial. convulsant drugs, such as phenytoin, inhibit
Chick (1999) has reviewed the available evi- folate absorption.
dence and found that 13 out of 16 population
studies associated light or moderate drinking
Thiamine
with better emotional wellbeing and social
adjustment. Table 2 provides a definition of Benton and Donohoe (1999) outlined a number
drinking habits. It is not clear, however, if these of studies showing that a poor thiamine status
studies demonstrate cause or effect. For example, (but not necessarily a clinical deficiency) might
it could be that the social opportunities linked to be linked to negative mood states. For example:
light drinking provide the emotional benefits, ■ Poor thiamine status was linked with intro-
rather than the alcohol itself. A few studies version, inactivity, fatigue and decreased self-
carried out in institutions for older people have confidence in young adult males.
found that light drinking associated with social ■ Taking daily supplements of 10mg of
activity is beneficial (Becker and Cesar 1973, thiamine for six weeks was associated with
Mishara et al 1975). In the same way, going to greater feelings of wellbeing and less fatigue
the pub provides an opportunity to socialise, in a group of older females who had poor
which often improves mood. thiamine status to start with.
A review of the literature on drinking and cogni- ■ An improvement in thiamine status in young
tive ability (Parsons 1998) concluded that there is adult females was associated with reports of
a safe threshold of about 21 or 28 units of alcohol being more clearheaded and energetic.
per week for women and men respectively (3 or 4 However, thiamine deficiency is so rare in the UK
units per day), after which is a continuum of population that it is unlikely to be an important
decline. One unit of alcohol is found in a small determinant of mood. It is, however, responsible
glass of wine, one measure of spirits or half a pint for the severe psychological effects of Wernicke-
of lager. People drinking five or six units a day Korsakoff’s syndrome seen in some alcoholics.
were found to have some cognitive inefficiencies,
those drinking seven to nine units a day showed
Iron and lethargy
mild cognitive deficits, and more that ten units a
day led to cognitive deficits equivalent to those Iron deficiency is one of the most common
found in diagnosed alcoholics. deficiencies in the developed and developing
worlds. In 1990, a study found that 4 per cent
of British women had haemoglobin levels below
Folic acid
11g/dl, the level used to indicate anaemia
The importance of folic acid has hit the head- (MAFF/DoH 1990). Another study in 1995 found
lines recently in relation to the prevention of that one in 12 of a nationally representative
neural tube defects, but it also has an important sample of pre-school children were anaemic
role in the brain. Young (1993) reviewed a (MAFF/DoH 1995).
number of studies, which show that folic acid It is well documented that anaemia results in
deficiency is linked to depressed mood, and feelings of fatigue, apathy and depressed mood.
that these symptoms can be present in the It has also been suggested that a low iron status
absence of serious deficiency. A study carried without frank anaemia might contribute to feel-
out by Coppen et al (1986) treated patients ings of anxiety and depression (Rangan et al
who were on long-term antidepressants with 1998). The tiredness resulting from a low iron
folic acid or placebo. After one year, those with status could also decrease the motivation for
the highest folate levels showed a significant exercise (Benton and Donohoe 1999), depress-
improvement in their disorders. It is thought that ing mood still further.
folate also exerts mood-raising effects via sero-
tonin, although the mechanism is unknown. TIME OUT 5
Although deficiencies in vitamins such as folic Using reference material, give
acid are rare in the general population, they can examples of foods that might
occur in people with disordered eating habits. be recommended for
Psychiatric patients are particularly prone to someone with iron deficiency
folate deficiency and it is estimated that between anaemia. What foods/nutrients will
one half and one third suffer from this problem increase the uptake of iron? What might
decrease iron uptake if consumed at the
(Carney 1990). People suffering from depression,
same time as iron-containing foods?
dementia and schizophrenia commonly lose their